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Hui Wang, Bin Fang, Lin Kong, Xiangzi Li, Zhijun Feng, Yunjun Wu, Kajsa Uvdal, Zhangjun Hu
A novel donor-π-acceptor-π-donor type (D-π-A-π-D') Schiff base derivative (L) has been designed and synthesized. The structure of L is confirmed by single-crystal X-ray diffraction analysis as well. The photophysical properties of compound L were comprehensively investigated by using both experimental and theoretical methods. The results indicate that L exhibits large Stokes shift and moderate two-photon action (2PA) cross-section in the near infrared (NIR) region. Furthermore, the confocal microscopy imaging study demonstrates that compound L could penetrate into cells and target the cellular mitochondria compartment...
March 13, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Li-Ping Hou, Hongxing Chen, Chang-En Tian, Ye Liang, Rong-Rong Wu, Xing-Mei Zhang, Xu-Wen Fang, Cui-Ping Zhang, Jun-Jie Hu, Li-Ying Song, Yan-Qiu Liang, Daniel Schlenk, Lingtian Xie
Synthetic hormones in wastewater effluents released into the aquatic environments may interfere with the normal endocrine systems of fish in receiving streams. Norgestrel (NGT) is a synthetic progestin widely used in oral contraceptives and frequently detected in wastewater effluents. In this study, adult female mosquitofish (Gambusia affinis) were exposed to three environmentally relevant concentrations of norgestrel (NGT) (i.e., 3.6, 35.8, and 368.0 ng L-1) for 42 d, fin morphology, histology of the ovary, and reproductive behaviors were evaluated...
March 13, 2018: Aquatic Toxicology
Min Cheng, Guangming Zeng, Danlian Huang, Cui Lai, Yang Liu, Chen Zhang, Jia Wan, Liang Hu, Chengyun Zhou, Weiping Xiong
The presence of antibiotics in aquatic environments has attracted global concern. Fenton process is an attractive yet challenging method for antibiotics degradation, especially when such a reaction can be conducted at neutral pH values. In this study, a novel composite Fe/Co catalyst was synthesized via the modification of steel converter slag (SCS) by salicylic acid-methanol (SAM) and cobalt nitrate (Co(NO3 )2 ). The catalysts were characterized by N2 -Brunauer-Emmett-Teller (BET), X-ray diffraction (XRD), Fourier transform infrared (FT-IR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS)...
March 10, 2018: Water Research
Dongdong Guo, Xinyi Hu, Haojie Zhang, Chenghua Lu, Guangwei Cui, Xingjing Luo
Neuropathic pain affects patients worldwide. The therapeutic effects of current methods are still poor. This study was performed to investigate the neuro-protective effect of orientin in rats with spinal nerve ligation (SNL). In this study, the paw mechanical withdrawal threshold (PWT) and the paw thermal withdrawal latency (PWL) behavioral assays indicated that orientin alleviated the warm and mechanical allodynia in rats with SNL. The enzyme-linked immunosorbent assay (ELISA) showed that orientin suppressed the levels of pro-inflammatory cytokines interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor alpha (TNF-α) and increased the levels of anti-inflammatory cytokine interleukin-10 (IL-10)...
March 17, 2018: International Immunopharmacology
Jiankui Feng, Erwei Yin, Jing Jin, Rami Saab, Ian Daly, Xingyu Wang, Dewen Hu, Andrzej Cichocki
The start of the cue is often used to initiate the feature window used to control motor imagery (MI)-based brain-computer interface (BCI) systems. However, the time latency during an MI period varies between trials for each participant. Fixing the starting time point of MI features can lead to decreased system performance in MI-based BCI systems. To address this issue, we propose a novel correlation-based time window selection (CTWS) algorithm for MI-based BCIs. Specifically, the optimized reference signals for each class were selected based on correlation analysis and performance evaluation...
March 2, 2018: Neural Networks: the Official Journal of the International Neural Network Society
Lei Hu, Feiyu Qin, Andrea Sanson, Liang-Feng Huang, Zhao Pan, Qiang Li, Qiang Sun, Lu Wang, Fangming Guo, Umut Aydemir, Yang Ren, Chengjun Sun, Jinxia Deng, Giuliana Aquilanti, James M Rondinelli, Jun Chen, Xianran Xing
The local symmetry, beyond the averaged crystallographic structure, tends to bring unusual performances. Negative thermal expansion is a peculiar physical property of solids. Here, we report the delicate design of the localized symmetry breaking to achieve the controllable thermal ex-pansion in ScF3 nano-scale frameworks. Intriguingly, an iso-tropic zero thermal expansion is concurrently engineered by localized symmetry breaking, with a remarkably low coefficient of thermal expansion of about +4.0×10-8/K up to 675K...
March 20, 2018: Journal of the American Chemical Society
Shimeng Zhu, Jiecai Fu, Hongli Li, Liu Zhu, Yang Hu, Weixing Xia, Xixiang Zhang, Yong Peng, Junli Zhang
Discovering the effect of magnetic anisotropy on the magnetization configurations of magnetic nanomaterials is essential and significant for not only enriching the fundamental knowledge of magnetics, but also facilitating the designs of desired magnetic nanostructures for diverse technological applications, such as data storage devices, spintronic devices, and magnetic nanosensors. Herein, we present a direct observation of magnetocrystalline anisotropy tuning magnetization configurations in uniaxial magnetic nanomaterials with hexagonal structure by means of three modeled samples...
March 20, 2018: ACS Nano
Hui Hu, Boyi Zhang, Adam Luxon, Thais Scott, Baoshan Wang, Carol A Parish
The 9,10-didehydroanthracene is an aromatic diradical produced by the Bergman cyclization of a benzannulated 10-membered enediyne. It is a 1,4 diradical, similar to para-benzyne. Here we study the spin state occupancy of the ground state of 9,10-didehydroanthracene by employing multireference methods (MR-CISD and MR-AQCC) with different basis sets (cc-pVDZ and cc-pVTZ) and active space sizes (CAS (2,2) through CAS (8,8)). At the CAS (8,8) MR-AQCC/cc-pVDZ level of theory, we find a two-configurational singlet ground state with an adiabatic EST of 6...
March 20, 2018: Journal of Physical Chemistry. A
Jiwen Jian, Shu-Xian Hu, Wan-Lu Li, Michael J van Stipdonk, Jonathan Martens, Giel Berden, Jos Oomens, Jun Li, John K Gibson
The following gas-phase uranyl/12-crown-4 (12C4) complexes were synthesized by electrospray ionization: [UO2 (12C4)2 ]2+ and [UO2 (12C4)2 (OH)]+ . Collision-induced dissociation (CID) of the dication resulted in [UO2 (12C4-H)]+ (12C4-H is a 12C4 that has lost one H), which spontaneously adds water to yield [UO2 (12C4-H)(H2 O)]+ . The latter has the same composition as complex [UO2 (12C4)(OH)]+ produced by CID of [UO2 (12C4)2 (OH)]+ but exhibits different reactivity with water. The postulated structures as isomeric [UO2 (12C4-H)(H2 O)]+ and [UO2 (12C4)(OH)]+ were confirmed by comparison of infrared multiphoton dissociation (IRMPD) spectra with computed spectra...
March 20, 2018: Inorganic Chemistry
Chengbo Tian, Shujing Zhang, Anyi Mei, Yaoguang Rong, Yue Hu, Kai Du, Miao Duan, Yusong Sheng, Pei Jiang, Gengzhao Xu, Hongwei Han
The printable mesoscopic perovskite solar cells (PMPSCs) have exhibited great attracting prospects in the energy conversion field due to their high stability and potential scalability. However, the thick perovskite film in the mesoporous layers challenge the charge transportation and increase grain boundary defects, limiting the performance of the PMPSCs. It is critical not only to improve the electric property of the perovskite film but also to passivate the charge traps to improve the device performance. Herein we synthesized a bis-adduct 2, 5-(Dimethyl ester) C60 fulleropyrrolidine (bis-DMEC60 ) via rational molecular design and incorporated it into the PMPSCs...
March 20, 2018: ACS Applied Materials & Interfaces
Zhihui Lu, Nana Song, Bo Shen, XiaLian Xu, Yi Fang, Yiqin Shi, Yichun Ning, Jiachang Hu, Yan Dai, Xiaoqiang Ding, Jianzhou Zou, Jie Teng
BACKGROUND: The hepatocyte growth factor (HGF) target pathway plays pivotal renoprotective roles after acute kidney injury (AKI). Syndecan-1 serves as the co-receptor for HGF. Shedding of syndecan-1 is involved in various pathological processes. Thus, we hypothesized that IRI induced syndecan-1 shedding and inhibiting syndecan-1 shedding would protect against kidney injury by potentiating activation of the HGF receptor c-Met. METHODS: Expression of syndecan-1 and its sheddases were observed in kidneys of sham and I/R mice...
March 20, 2018: Transplantation
Yuhan Zhao, Lihua Wu, Xuetian Yue, Cen Zhang, Jianming Wang, Jun Li, Xiaohui Sun, Yiming Zhu, Zhaohui Feng, Wenwei Hu
Tumor suppressor p53 prevents early death due to cancer development. However, the role of p53 in aging process and longevity has not been well-established. In humans, single nucleotide polymorphism (SNP) with either arginine (R72) or proline (P72) at codon 72 influences p53 activity; the P72 allele has a weaker p53 activity and function in tumor suppression. Here, employing a mouse model with knock-in of human TP53 gene carrying codon 72 SNP, we found that despite increased cancer risk, P72 mice that escape tumor development display a longer lifespan than R72 mice...
March 20, 2018: ELife
Guo Wang, Wei-Bo Hu, Xiao-Li Zhao, Yahu A Liu, Jiu-Sheng Li, Biao Jiang, Ke Wen
A supramolecular organic framework, P5-bpy-SOF, made of perhydroxyl-pillar[5]arene (P5) and 4,4-bipyridine (bpy) and prepared by using a co-crystallization approach, showed a different hydrogen bonding pattern and a 3D molecular arrangement from that in the perhydroxyl-pillar[5]arene-based supramolecular organic framework (P5-SOF). TGA analyses, powder X-ray diffraction and gas absorption study confirmed P5-bpy-SOF's structural stability, permanent porosity, and, especially, selectivity of absorption of CO2 over N2...
March 20, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Yoshitaka Inui, Takashi Ichihara, Masaki Uno, Masanobu Ishiguro, Kengo Ito, Katsuhiko Kato, Hajime Sakuma, Hidehiko Okazawa, Hiroshi Toyama
OBJECTIVE: Statistical image analysis of brain SPECT images has improved diagnostic accuracy for brain disorders. However, the results of statistical analysis vary depending on the institution even when they use a common normal database (NDB), due to different intrinsic spatial resolutions or correction methods. The present study aimed to evaluate the correction of spatial resolution differences between equipment and examine the differences in skull bone attenuation to construct a common NDB for use in multicenter settings...
March 19, 2018: Annals of Nuclear Medicine
Yuming Hu, Chuanzhu Yi, Jingguang Li, Xiaohong Shang, Zimin Li, Xiaochen Yin, Bo Chen, Yuechan Zhou, Yinyin Zhang, Yongning Wu
Japanese schistosomiasis was endemic in Dongting Lake, the second largest freshwater lake in China. The technical sodium pentachlorophenate (Na-PCP) was widely used during the period between the early 1960s and early 1990s to kill oncomelania, the intermediate host of Schistosomes. However, polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) also contaminated the environment of Dongting Lake due to trace impurities of Na-PCP. In this study, 13 species of freshwater fish were collected from Dongting Lake and analyzed in wet and dry seasons...
March 19, 2018: Environmental Monitoring and Assessment
Irene Maffucci, Xiao Hu, Valentina Fumagalli, Alessandro Contini
Nwat-MMGBSA is a variant of MM-PB/GBSA based on the inclusion of a number of explicit water molecules that are the closest to the ligand in each frame of a molecular dynamics trajectory. This method demonstrated improved correlations between calculated and experimental binding energies in both protein-protein interactions and ligand-receptor complexes, in comparison to the standard MM-GBSA. A protocol optimization, aimed to maximize efficacy and efficiency, is discussed here considering penicillopepsin, HIV1-protease, and BCL-XL as test cases...
2018: Frontiers in Chemistry
Adam Vandergriff, Ke Huang, Deliang Shen, Shiqi Hu, Michael Taylor Hensley, Thomas G Caranasos, Li Qian, Ke Cheng
Rationale: Cardiac stem cell-derived exosomes have been demonstrated to promote cardiac regeneration following myocardial infarction in preclinical studies. Recent studies have used intramyocardial injection in order to concentrate exosomes in the infarct. Though effective in a research setting, this method is not clinically appealing due to its invasive nature. We propose the use of a targeting peptide, cardiac homing peptide (CHP), to target intravenously-infused exosomes to the infarcted heart. Methods: Exosomes were conjugated with CHP through a DOPE-NHS linker...
2018: Theranostics
Chunhui Lai, Siliang Duan, Fang Ye, Xiaoqiong Hou, Xi Li, Jin Zhao, Xia Yu, Zixi Hu, Zhuoran Tang, Fengzhen Mo, Xiaomei Yang, Xiaoling Lu
PURPOSE: Dendritic cell (DC)-based cancer vaccines is a newly emerging and potent form of immune therapy. As for any new technology, there are still considerable challenges that need to be addressed. Here, we investigate the antitumor potential of a novel liposomal vaccine, M/CpG-ODN-TRP2-Lipo. METHODS: We developed a vaccination strategy by assembling the DC-targeting mannose and immune adjuvant CpG-ODN on the surface of liposomes, which were loaded with melanoma-specific TRP2180-188 peptide as liposomal vaccine...
2018: Theranostics
Yunlei Zhang, Wei Ji, Lian He, Yiyan Chen, Xuezhi Ding, Yunjun Sun, Shengbiao Hu, Huijun Yang, Weitao Huang, Youming Zhang, Fei Liu, Liqiu Xia
Purpose: Systemic administration of free chemotherapeutic drugs leads to severe toxic effects, and physiological characteristics of solid tumors restrain the drugs from reaching the hypoxic regions. E. coli Nissle 1917 (EcN) has been known to penetrate the barrier and proliferate in the interface between the viable and necrotic regions of tumors. This study aimed to fabricate a nanoscale minicell via genetic engineering of EcN for targeted delivery of chemotherapeutic drugs to the hypoxic regions of tumors for cancer therapy...
2018: Theranostics
Chun-Yuan Chen, Shan-Shan Rao, Lu Ren, Xiong-Ke Hu, Yi-Juan Tan, Yin Hu, Juan Luo, Yi-Wei Liu, Hao Yin, Jie Huang, Jia Cao, Zhen-Xing Wang, Zheng-Zhao Liu, Hao-Ming Liu, Si-Yuan Tang, Ran Xu, Hui Xie
Chronic non-healing wounds represent one of the most common complications of diabetes and need advanced treatment strategies. Exosomes are key mediators of cell paracrine action and can be directly utilized as therapeutic agents for tissue repair and regeneration. Here, we explored the effects of exosomes from human urine-derived stem cells (USC-Exos) on diabetic wound healing and the underlying mechanism. Methods: USCs were characterized by flow cytometry and multipotent differentiation potential analyses...
2018: Theranostics
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