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https://www.readbyqxmd.com/read/28723302/why-use-group-visits-for-opioid-use-disorder-treatment-in-primary-care-a-patient-centered-qualitative-study
#1
Randi Sokol, Chiara Albanese, Deviney Chaponis, Jessica Early, George Maxted, Diana Morrill, Grace Poirier, Fran Puopolo, Zev Schuman-Olivier
BACKGROUND: Primary care providers are well positioned to respond to the opioid crisis by providing buprenorphine/naloxone (B/N) through shared medical appointments (SMA). While quantitative research has been previously conducted on SMAs with B/N, we conducted a qualitative assessment from the patients' point of view, considering whether and how group visits provide value for patients. METHODS: Twenty-five participants with opioid use disorder (OUD) who were enrolled in a weekly B/N group visit at a family medicine clinic participated in either of two one-hour-long focus groups, which were conducted as actual group visits...
July 19, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28721966/use-of-skin-lightening-products-among-outpatient-attendees-in-a-north-indian-hospital
#2
Celestine Wong, Samuel Wong, Howard Tang, Rashi Minocha, Rajesh Singh, Nathan Grills
In India, fair skin is a highly valued physical attribute. Skin lightener products comprise 60% of the dermatological market. This cross-sectional study was conducted in the general medical outpatient clinics of Champa Christian Hospital to elucidate the perceptions of fair skin and determinants/pattern of skin lighter use. Demographics, pattern of skin lightener use and incidence of side effects, perceptions of lighter skin tones were the main outcomes and measures studied. The use of skin lighteners was highly prevalent in our study population...
April 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28717134/ash-production-by-attrition-in-volcanic-conduits-and-plumes
#3
T J Jones, J K Russell
Tephra deposits result from explosive volcanic eruption and serve as indirect probes into fragmentation processes operating in subsurface volcanic conduits. Primary magmatic fragmentation creates a population of pyroclasts through volatile-driven decompression during conduit ascent. In this study, we explore the role that secondary fragmentation, specifically attrition, has in transforming primary pyroclasts upon transport in volcanic conduits and plumes. We utilize total grain size distributions from a suite of natural and experimentally produced tephra to show that attrition is likely to occur in all explosive volcanic eruptions...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28707403/melanocytic-lesion-evolution-patterns-with-targeted-therapies-and-immunotherapies-for-advanced-metastatic-melanoma-an-observational-study
#4
Cathy Yunjia Zhao, Shelley Ji Eun Hwang, Deepal Wakade, Giuliana Carlos, Rachael Anforth, Pablo Fernández-Peñas
BACKGROUND/OBJECTIVES: Various cutaneous side-effects have been reported with anti-melanoma systemic therapies. This study investigated the changes in melanocytic lesion pigmentation in patients on four different therapies. METHODS: We analysed the serial dermatoscopic photographs of atypical melanocytic lesions taken from patients with advanced metastatic melanoma on four different systemic therapies (selective BRAF-inhibitor monotherapy, dabrafenib combined with trametinib [D&T], anti-programmed cell death protein 1 [anti-PD1] therapies, and anti-PD1 combined with ipilimumab) seen from February 2013 to May 2016...
July 14, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28706755/effects-of-a-novel-whitening-formulation-on-dental-enamel
#5
Thair Takesh, Anik Sargsyan, Afarin Anbarani, Jessica Ho, Petra Wilder-Smith
OBJECTIVE: The goal of this study was to evaluate the enamel whitening effects of 2 new test formulations, one of which was a rinse, and the other a whitening strip. MATERIALS AND METHODS: Forty enamel chips were prepared from 20 healthy extracted teeth (2 from each tooth). After pre-staining and colorimetry to measure L* and b* values, 20 matched samples were immersed in either test or control rinses, and then colorimetry was performed again after 1 hr, 2 hr, 3 hr, 6 hr, 12 hr, 24 hr and 48 hrs (Each hour equates to one month of clinical use at the recommended dosage of 1 minute exposure 2 times a day)...
April 2017: Dentistry: Current Research
https://www.readbyqxmd.com/read/28693803/the-see-saw-of-keap1-nrf2-pathway-in-cancer
#6
REVIEW
Poorti Pandey, Alok Kumar Singh, Mritunjai Singh, Mallika Tewari, Hari Shankar Shukla, Indrajeet Singh Gambhir
Keap1-Nrf2 pathway is continuously involved in the cytoprotection from oxidative stress generated due to various factors either extrinsic or intrinsic in origin. This role of Nrf2 in the response to oxidative stress is well established. Following oxidative insult, Nrf2 mediates the regulation of the inducible expression of cytoprotective genes. The level and functional capacity of Nrf2 is regulated at the post-transcriptional level, mainly through its association with an actin-associated protein, Keap1. Various studies reported that any discrepancy from their routine may lead to promotion of tumor as well...
August 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28690787/the-effects-of-historical-fragmentation-on-major-histocompatibility-complex-class-ii-%C3%AE-and-microsatellite-variation-in-the-aegean-island-reptile-podarcis-erhardii
#7
Trent Santonastaso, Jackie Lighten, Cock van Oosterhout, Kenneth L Jones, Johannes Foufopoulos, Nicola M Anthony
The major histocompatibility complex (MHC) plays a key role in disease resistance and is the most polymorphic gene region in vertebrates. Although habitat fragmentation is predicted to lead to a loss in MHC variation through drift, the impact of other evolutionary forces may counter this effect. Here we assess the impact of selection, drift, migration, and recombination on MHC class II and microsatellite variability in 14 island populations of the Aegean wall lizard Podarcis erhardii. Lizards were sampled from islands within the Cyclades (Greece) formed by rising sea levels as the last glacial maximum approximately 20,000 before present...
July 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28689798/ethyl-acetate-extract-from-panax-ginseng-c-a-meyer-and-its-main-constituents-inhibit-%C3%AE-melanocyte-stimulating-hormone-induced-melanogenesis-by-suppressing-oxidative-stress-in-b16-mouse-melanoma-cells
#8
Rui Jiang, Xiao-Hao Xu, Ke Wang, Xin-Zhao Yang, Ying-Fei Bi, Yao Yan, Jian-Zeng Liu, Xue-Nan Chen, Zhen-Zhong Wang, Xiao-Li Guo, Da-Qing Zhao, Li-Wei Sun
ETHNOPHARMACOLOGICAL RELEVANCE: Hyperpigmentation disease involves darkening of the skin color due to melanin overproduction. Panax ginseng C.A. Meyer is a well-known traditional Chinese medicine and has a long history of use as a skin lightener to inhibit melanin formation in China, Korea and some other Asian countries. However, the constituents and the molecular mechanisms by which they affect melanogenesis are not fully clear. AIM OF THE STUDY: The purpose of this study was to identify the active ingredient in Panax ginseng C...
July 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28684314/inhibitory-effect-of-5-iodotubercidin-on-pigmentation
#9
Kyung-Il Kim, Hae Bong Jeong, Hyunju Ro, Jeung-Hoon Lee, Chang Deok Kim, Tae-Jin Yoon
Melanin pigments are the primary contributors for the skin color. They are produced in melanocytes and then transferred to keratinocytes, eventually giving various colors on skin surface. Although many depigmenting and/or skin-lightening agents have been developed, there is still a growing demand on materials for reducing pigmentation. We attempted to find materials for depigmentation and/or skin-lightening using the small molecule compounds commercially available, and found that 5-iodotubercidin had inhibitory potential on pigmentation...
July 3, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28612442/allergic-contact-dermatitis-caused-by-arbutin-and-dipotassium-glycyrrhizate-in-skin-lightening-products
#10
Naoki Oiso, Megumi Tatebayashi, Yasuko Hoshiyama, Akira Kawada
No abstract text is available yet for this article.
July 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28598111/-the-alterations-in-expression-of-the-synaptophysin-in-rat-brain-trauma-injury-model-an-experimental-study
#11
Yan-Chao Wang, Yu Zhang, Ting Lan, Xiao-Lin Ai, Yue-Chao Liang, Min He, Yang Li, Fang Fang
OBJECTIVES: To study the rat brain trauma injury model and investigate the rules of transformation of expression of synaptophysin and its relationship between histology and radiology alternation after brain trauma injury. METHODS: 24 SD male rats aged three months were randomly divided into 4 groups,including a control group of 6 rats.The experimental group rats were received operation to build free falling brain trauma injury model.The rat were analyzed at 2,4,8 weeks after injury...
November 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28597838/-collaboration-between-periodontics-and-orthodontics-interest-of-alveolar-corticotomies-and-piezocision-review-of-literature
#12
Brenda Mertens, Charles Angioni, Valérie Orti, Pierre Canal
INTRODUCTION: Orthodontics in adults must adapt to certain particularities especially related to the decrease or absence of growth and the prevalence of periodontal damage in this population. This review of the literature aims to assess the effects of alveolar corticotomies on accelerating or facilitating tooth movements in different types of orthodontic movements, to compare results obtained by classical technique with those obtained by piezocision and analyze their impact on periodontal tissues in the long term...
June 2017: L' Orthodontie Française
https://www.readbyqxmd.com/read/28583673/high-level-de-novo-biosynthesis-of-arbutin-in-engineered-escherichia-coli
#13
Xiaolin Shen, Jia Wang, Jian Wang, Zhenya Chen, Qipeng Yuan, Yajun Yan
Arbutin is a hydroquinone glucoside compound existing in various plants. It is widely used in pharmaceutical and cosmetic industries owing to its well-known skin-lightening property as well as anti-oxidant, anti-microbial, and anti-inflammatory activities. Currently, arbutin is usually produced by plant extraction or enzymatic processes, which suffer from low product yield and expensive processing cost. In this work, we established an artificial pathway in Escherichia coli for high-level production of arbutin from simple carbon sources...
June 2, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28554823/mercury-contamination-in-facial-skin-lightening-creams-and-its-health-risks-to-user
#14
Yu Bin Ho, Nor Hidayu Abdullah, Hazwanee Hamsan, Eugenie Sin Sing Tan
This study aims to determine concentrations of mercury in facial skin lightening cream according to different price categories (category I: <RM29.99, category II: RM30.00-RM59.99, category III: RM60.00-RM99.99 and category IV: ≥RM100.00) and their potential health risks to users. Prices of skin lightening creams were determined during a preliminary market survey. Thereafter, twenty samples were purchased from various locations such as cosmetic stalls, beauty shops, pharmacies and street vendors based on their stratified price categories...
May 26, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28552424/physicochemical-and-colloidal-aspects-of-food-matrix-effects-on-gastrointestinal-fate-of-ingested-inorganic-nanoparticles
#15
REVIEW
David Julian McClements, Hang Xiao, Philip Demokritou
Inorganic nanoparticles, such as titanium dioxide, silicon dioxide, iron oxide, zinc oxide, or silver nanoparticles, are added to some food products and food packaging materials to obtain specific functional attributes, such as lightening, powder flow, nutrition, or antimicrobial properties. These engineered nanomaterials (ENMs) all have dimensions below 100nm, but may still vary considerably in composition, morphology, charge, surface properties and aggregation state, which effects their gastrointestinal fate and potential toxicity...
May 9, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28512843/assessment-of-the-efficacy-and-safety-of-a-new-complex-skin-cream-in-asian-women-a-controlled-clinical-trial
#16
Yu Seok Jung, Ji Hae Lee, Jung Min Bae, Dong Won Lee, Gyong Moon Kim
BACKGROUND: Medical products such as hydroquinone and tretinoin have been widely used to treat various types of skin hyperpigmentation. However, these products are limited in daily use given their adverse effects. Other alternative agents with fewer adverse side effects have been developed. However, single agents often do not produce satisfactory results. AIMS: To evaluate the efficacy and safety of a new brightening complex cream containing niacinamide, tranexamic acid, oxyresveratrol, glutathione disulfide, and linoleic acid...
May 16, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28494565/-the-protection-of-hydrogen-rich-saline-on-a-rat-dry-eye-model-induced-by-scopolamine-hydrobromide
#17
Y Y Chu, N Hua, Y S Ru, S Z Zhao
Objective: To evaluate the effect of hydrogen-rich saline (HRS) on dry eye rats induced by subcutaneous injection of scopolamine hydrobromide. Methods: Experiment research. Thirty female Wistar rats at about six weeks old were randomly divided into the normal group, dry eye group, HRS eyedrops group, normal saline eyedrops group (NS), HRS intraperitoneal injection group and NS intraperitoneal injection group, with 5 rats in each group. The dry eye was induced by subcutaneous injection of scopolamine hydrobromide in the latter five groups...
May 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28490897/glutathione-and-its-antiaging-and-antimelanogenic-effects
#18
Sinee Weschawalit, Siriwan Thongthip, Phanupong Phutrakool, Pravit Asawanonda
BACKGROUND: Previous studies showed that supplementation of reduced form of glutathione (GSH, 500 mg/d) has a skin-lightening efficacy in humans. This study was designed to evaluate the influences of both GSH and oxidized form (GSSG), at doses lower than 500 mg/d, on improving skin properties. PATIENTS AND METHODS: A randomized, double-blind, placebo-controlled, parallel, three-arm study was conducted. Healthy female subjects were equally randomized into three groups and took GSH (250 mg/d), GSSG (250 mg/d), or placebo orally for 12 weeks...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28481757/vermillion-reconstruction-with-anal-verge-transitional-epithelium-turning-things-upside-down
#19
Benjamin Levi, Joseph A Ricci, Matthias B Donelan
Postburn lip deformities pose a significant set of challenges to reconstructive burn surgeons because of the complex anatomy, diverse functions, and specialized nature of the lip tissues. There has been a paucity of literature on restoration of the vermillion to date. The authors report on two patients who suffered burn injuries resulting in significant lip deformities who underwent a novel method of vermillion reconstruction with a full thickness anal verge skin graft. Both patients tolerated the procedure well without complications...
May 4, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28480125/the-most-effective-methods-for-delivering-severe-weather-early-warnings-to-fishermen-on-lake-victoria
#20
Richard Tushemereirwe, Doreen Tuhebwe, Mary Ann Cooper, Florence Mutonyi D'ujanga
Introduction: It is estimated that five thousand people die on Lake Victoria every year by drowning which is triggered by severe weather hazards like lightning. Objectives:  In order to improve predictability of severe weather conditions on Lake Victoria, there is need to deliver timely and effective Severe Weather Early Warning Systems (SWEWS) to those at risk. On Lake Victoria, previous SWEW service trials ceased with the end of the funding grants. This study therefore assessed the possibility of sustaining the SWEW service by assessing willingness to pay...
February 22, 2017: PLoS Currents
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