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https://www.readbyqxmd.com/read/27913685/novel-biomarkers-in-kidney-disease-roles-for-cilia-wnt-signalling-and-atmin-in-polycystic-kidney-disease
#1
REVIEW
Paraskevi Goggolidou, Patricia D Wilson
Biomarkers, the measurable indicators of biological conditions, are fast becoming a popular approach in providing information to track disease processes that could lead to novel therapeutic interventions for chronic conditions. Inherited, chronic kidney disease affects millions of people worldwide and although pharmacological treatments exist for some conditions, there are still patients whose only option is kidney dialysis and kidney transplantation. In the past 10 years, certain chronic kidney diseases have been reclassified as ciliopathies...
December 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27911217/laser-toning-for-melasma-a-single-center-experience-with-38-970-cases
#2
Brian Tian
Melasma is a common pigmentation in Asian women. Lasers have been used to lighten melasma, although with variable outcomes and complications. In Asia, laser toning is a common technique used to safely lighten melasma. However, no large studies have been performed to validate efficacy. In our study, we demonstrate that in 38,970 Asian women, at least 35,890 patients (92.1%) had noticeable to excellent improvement in their melasma.
December 2, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27888376/laser-flare-cell-photometer-principle-and-significance-in-clinical-and-basic-ophthalmology
#3
REVIEW
Mitsuru Sawa
A slit-lamp examination is an indispensable and essential clinical evaluation method in ophthalmology, but, it is qualitative subjective. To complement its weaknesses in making a quantitative evaluation of flare intensity and number of cells in the aqueous humor in the eye, we invented the laser flare-cell photometer in 1988. The instrument enables a non-invasive quantitative evaluation of flare intensity and number of cells in the aqueous with good accuracy and repeatability as well as maneuverability equal to slit-lamp microscopy...
November 25, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27862009/development-and-validation-of-an-ultraviolet-visible-uv-vis-spectrophotometric-method-for-determination-of-phenylethyl-resorcinol-in-new-topical-nanoemulsions
#4
Liang Hong, Dan Han, Ming-Xin Li, Pei Zhang, Chen-Guang Liu
OBJECTIVE: To develop a rapid, simple and efficient Ultraviolet-visible (UV-Vis) spectrophotometric method for the quantification of phenylethyl resorcinol (PR), a potent skin-lightening agent, incorporated into new topical nanoemulsions, and to validate this method according to International Commission for Harmonization (ICH) guidelines. METHODS: UV-Vis spectrophotometric method for quantification of PR in new topical nanoemulsions was developed and validated in terms of specificity, linearity, sensitivity, precision, and accuracy...
November 9, 2016: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/27853546/adaptive-phenotypic-response-to-climate-enabled-by-epigenetics-in-a-k-strategy-species-the-fish-leucoraja-ocellata-rajidae
#5
Jackie Lighten, Danny Incarnato, Ben J Ward, Cock van Oosterhout, Ian Bradbury, Mark Hanson, Paul Bentzen
The relative importance of genetic versus epigenetic changes in adaptive evolution is a hotly debated topic, with studies showing that some species appear to be able to adapt rapidly without significant genetic change. Epigenetic mechanisms may be particularly important for the evolutionary potential of species with long maturation times and low reproductive potential ('K-strategists'), particularly when faced with rapidly changing environmental conditions. Here we study the transcriptome of two populations of the winter skate (Leucoraja ocellata), a typical 'K-strategist', in Atlantic Canada; an endemic population in the southern Gulf of St Lawrence and a large population on the Scotian Shelf...
October 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27851907/the-depigmenting-effect-of-natural-resorcinol-type-polyphenols-kuwanon-o-and-sanggenon-t-from-the-roots-of-morus-australis
#6
Shuting Hu, Zongping Zheng, Feng Chen, Mingfu Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Morus australis, one of the major Morus species growing in East Asia, is rich in phenolic compounds. The extract of M. australis has been used as skin whitening components for a long period. The action mechanisms of its principal constituents are still unclear. This study aims to evaluate the skin lightening effects of phenolic compounds extracted from the root of M. australis in different melanocyte systems and artificial skin models. MATERIALS AND METHODS: The depigmenting effect of resorcinol type polyphenols (RTPs) from the root extract of M...
November 13, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27829416/tyrosinase-inhibition-and-antioxidant-properties-of-asphodelus-microcarpus-extracts
#7
Amalia Di Petrillo, Ana Maria González-Paramás, Benedetta Era, Rosaria Medda, Francesca Pintus, Celestino Santos-Buelga, Antonella Fais
BACKGROUND: Asphodelus microcarpus belongs to the family Liliaceae that include several medicinal plants. In the traditional medicine plants of the genus Asphodelus are used to treat skin disorders such as ectodermal parasites, psoriasis, microbial infection and for lightening freckles. In order to find novel skin depigmenting agents, the present work was carry out to evaluate antioxidant activity and tyrosinase inhibitory potential of leaves, flowers and tubers extracts of A. microcarpus...
November 9, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27826660/-evaluation-of-the-decision-aid-entscheidungshilfe-prostatakrebs-from-the-patients-view-results-from-the-first-three-months
#8
C Groeben, A Ihrig, T Hölscher, T Krones, E Kessler, S Kliesch, C Wülfing, R Koch, M P Wirth, J Huber
BACKGROUND: The decision aid "Entscheidungshilfe Prostatakrebs" is available online free of charge since June 2016. It is designed to support patients with their treatment decision-making and to lighten the burden on their treating urologists. This study evaluates usage data from the first 3 months. MATERIALS AND METHODS: The ICHOM standard set was applied to allow a personalised presentation and to collect relevant data for subsequent counselling. Additionally, personal preferences and psychological burden were assessed amongst others...
November 8, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27801448/characterization-and-utilization-of-prussian-blue-and-its-pigments
#9
Fernande Grandjean, Louise Samain, Gary J Long
This review deals with our long-range goal of determining why the Prussian blue pigments, typically either the "soluble" KFe(III)[Fe(II)(CN)6]·xH2O or the alternative "insoluble" Fe[Fe(II)(CN)6]3·xH2O compounds, used by artists from shortly after the discovery of Prussian blue in 1704 and well into the early twentieth century, often fade when exposed to light. In order to achieve this goal it was decided that first, for comparison purposes, we had to prepare and fully characterize Prussian blues prepared by various, often commercially successful, synthetic methods...
November 1, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27793866/dementia-epilepsy-and-polyneuropathy-in-a-mercury-exposed-patient-investigation-identification-of-an-obscure-source-and-treatment
#10
Tobias Zellner, Nicolas Zellner, Norbert Felgenhauer, Florian Eyer
We present a patient aged 54 years with early onset of dementia, epilepsy and peripheral polyneuropathy. A mercury intoxication was diagnosed in 2010, chelation therapy with 2,3-dimercaptopropane-1-sulfonate had failed. A source of exposure could not be identified. MRI showed unspecific hyperintense brain lesions in 2015. She was referred for diagnosis and treatment. Neuropsychological testing indicated severe memory loss and nerve conduction speed measurements showed chronic neurogenically changed potentials...
October 28, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27785083/overall-skin-tone-and-skin-lightening-improving-effects-with-oral-supplementation-of-lutein-and-zeaxanthin-isomers-a-double-blind-placebo-controlled-clinical-trial
#11
Vijaya Juturu, James P Bowman, Jayant Deshpande
PURPOSE: Carotenoids, especially lutein and zeaxanthin isomers (L/Zi), filter blue light and protect skin from environmental factors including high-energy sources. These carotenoids may be able to block the formation of melanin pathways, decrease cytokines, and increase antioxidants. SUBJECTS AND METHODS: This is a randomized, double-blind, placebo-controlled clinical trial over a 12-week supplementation period. Fifty healthy people (50 healthy subjects were recruited and 46 subjects completed the study) (males and females, age: 18-45 years) with mild-to-moderate dry skin were included in this study...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27776184/deoxyarbutin-possesses-a-potent-skin-lightening-capacity-with-no-discernible-cytotoxicity-against-melanosomes
#12
Fang Miao, Ying Shi, Zhi-Feng Fan, Shan Jiang, Shi-Zheng Xu, Tie-Chi Lei
Safe and effective ingredients capable of removing undesired hyperpigmentation from facial skin are urgently needed for both pharmaceutical and cosmetic purposes. Deoxyarbutin (4-[(tetrahydro-2H-pyran-2-yl) oxy] phenol, D-Arb) is a glucoside derivative of hydroquinone. Here, we investigated the toxicity and efficacy of D-Arb at the sub-cellular level (directly on melanosomes) and skin pigmentation using in vivo and in vitro models to compare with its parent compound hydroquinone (1,4-benzenediol, HQ). At first, we examined the ultrastructural changes of melanosomes in hyperpigmented guinea pig skin induced by 308-nm monochromatic excimer lightand/or treated with HQ and D-Arb using transmission electron microscopy...
2016: PloS One
https://www.readbyqxmd.com/read/27730012/analysis-of-difference-in-center-of-pressure-positions-between-experts-and-novices-during-asymmetric-lifting
#13
Hieyong Jeong, Kenji Yamada, Michiko Kido, Shima Okada, Taishin Nomura, Yuko Ohno
Although numerous studies have analyzed the relationship between manual material handling (MMH) and the forces acting on the lumbar spine, the difference in the MMH between experts and novices through the analysis of measured data has not been well studied. The purpose of this paper was to analyze the difference in the MMH positions between ten skilled experts working at a freight transport company (Group 1) and five unskilled novices without any experience (Group 2) during asymmetric lifting. All the human subjects performed asymmetric lifting experiments with closed eyes; the experiments involved moving loads (6 and 18 kg) to the left side...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/27729746/application-of-side-to-side-anastomosis-of-the-lesser-curvature-of-stomach-and-jejunum-in-gastric-bypass
#14
Ri-Xing Bai, Wen-Mao Yan, You-Guo Li, Jun Xu, Zhi-Qiang Zhong, Ming Yan
AIM: To evaluate the feasibility of side-to-side anastomosis of the lesser curvature of stomach and jejunum in laparoscopic Roux-en-Y gastric bypass (LRYGB). METHODS: Seventy-seven patients received side-to-side anastomosis of the lesser curvature of stomach and jejunum by utilization of linear stapler in LRYGB from April 2012 to July 2015 were retrospectively analyzed. RESULTS: All patients were successfully completed laparoscopic gastric bypass with the side-to-side anastomosis of the lesser curvature of stomach and jejunum...
October 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27721049/jasmine-rice-panicle-a-safe-and-efficient-natural-ingredient-for-skin-aging-treatments
#15
Mayuree Kanlayavattanakul, Nattaya Lourith, Puxvadee Chaikul
ETHNOPHARMACOLOGICAL RELEVANCE: While rice is one of the most important global staple food sources its extracts have found many uses as the bases of herbal remedies. Rice extracts contain high levels of phenolic compounds which are known to be bioactive, some of which show cutaneous benefits and activity towards skin disorders. This study highlights an assessment of the cellular activity and clinical efficacy of rice panicle extract, providing necessary information relevant to the development of new cosmetic products...
October 6, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27714857/depigmentation-of-%C3%AE-melanocyte-stimulating-hormone-treated-melanoma-cells-by-%C3%AE-mangostin-is-mediated-by-selective-autophagy
#16
Ki Won Lee, Hyung Won Ryu, Sang-Seok Oh, Soojong Park, Hamadi Madhi, Jiyun Yoo, Ki-Hun Park, Kwang Dong Kim
Melanogenesis is a key pathway for the regulation of skin pigmentation and the development of skin-lightening/whitening drugs or cosmetics. In this study, we found that β-mangostin from seedcases of Garcinia mangostana inhibited α-melanocyte-stimulating hormone (α-MSH)-mediated melanogenesis in B16F10 melanoma cells and a three-dimensional human skin model. β-Mangostin significantly inhibited the protein level of tyrosinase induced by α-MSH in UPS (ubiquitin proteasome system)-independent and lysosome-dependent manner...
October 7, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27706019/antidermatophytic-action-of-resorcinol-derivatives-ultrastructural-evidence-of-the-activity-of-phenylethyl-resorcinol-against-microsporum-gypseum
#17
Carlo Romagnoli, Anna Baldisserotto, Chiara B Vicentini, Donatella Mares, Elisa Andreotti, Silvia Vertuani, Stefano Manfredini
In this work, we evaluated the antidermatophytic activities of three resorcinol derivatives that have a history of use in dermo-cosmetic applications to discover molecules with multiple dermatological activities (i.e., multi-target drugs), thereby reducing the cost and time necessary for new drug development. The antidermatophytic activities of the three skin lighteners were evaluated relative to the known antifungal drug fluconazole on nine dermatophytes responsible for the most common dermatomycoses: Microsporum gypseum, Microsporum canis, Trichophyton violaceum, Arthroderma cajetani, Trichophyton mentagrophytes, Epidermophyton floccosum, Nannizzia gypsea, Trichophyton rubrum and Trichophyton tonsurans...
September 30, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27695366/primary-dysmenorrhea-magnitude-associated-risk-factors-and-its-effect-on-academic-performance-evidence-from-female-university-students-in-ethiopia
#18
Solomon Hailemeskel, Asrate Demissie, Nigussie Assefa
BACKGROUND: Primary dysmenorrhea (PD) is the most common gynecologic compliant among adolescent females. There is a wide variation in the estimate of PD, which ranges from 50% to 90%, and the disorder is the most common cause of work and school absenteeism in adolescent females. OBJECTIVE: To assess the prevalence and associated risk factors of PD among female university students and understand its effects on students' academic performance. METHODS: A cross-sectional study was employed in 440 research participants...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27694042/how-effective-is-greening-policy-in-reducing-ghg-emissions-from-agriculture-evidence-from-italy
#19
Roberto Solazzo, Michele Donati, Licia Tomasi, Filippo Arfini
Agriculture contributes significantly to greenhouse gas (GHG) emissions, accounting for more than 10% of total CO2 emissions in the EU-28 area. The Common Agricultural Policy (CAP) plays an important role in promoting environmentally and climate friendly practices and needs to respond to the new environmental challenges by better integrating its objectives with other EU policies. In this respect, the recent CAP reform 2014-2020 made a further step, making a large part of direct payments conditional on new agricultural practices beneficial for the climate and the environment, i...
December 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27649711/-treatment-and-management-of-congenital-melanocytic-naevi
#20
Kamille-Amalie Bahn, Merete Hædersdal, Grethe Schmidt, Lisbet Rosenkrantz Hölmich
Congenital melanocytic naevi (CMN) appear in approximately 2.6% of Caucasians. There is a major demand for treatment but no vital indication. Laser therapy, curettage and excision are available treatment modalities, but there is no ideal treatment with documented long-term effect and without side effects, and the level of evidence for the treatment options is generally low. The risk of malignancy has probably been overestimated, and furthermore new research shows that untreated CMN often show spontaneous lightening...
September 19, 2016: Ugeskrift for Laeger
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