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Hieyong Jeong, Kenji Yamada, Michiko Kido, Shima Okada, Taishin Nomura, Yuko Ohno
Although numerous studies have analyzed the relationship between manual material handling (MMH) and the forces acting on the lumbar spine, the difference in the MMH between experts and novices through the analysis of measured data has not been well studied. The purpose of this paper was to analyze the difference in the MMH positions between ten skilled experts working at a freight transport company (Group 1) and five unskilled novices without any experience (Group 2) during asymmetric lifting. All the human subjects performed asymmetric lifting experiments with closed eyes; the experiments involved moving loads (6 and 18 kg) to the left side...
2016: IEEE Journal of Translational Engineering in Health and Medicine
Ri-Xing Bai, Wen-Mao Yan, You-Guo Li, Jun Xu, Zhi-Qiang Zhong, Ming Yan
AIM: To evaluate the feasibility of side-to-side anastomosis of the lesser curvature of stomach and jejunum in laparoscopic Roux-en-Y gastric bypass (LRYGB). METHODS: Seventy-seven patients received side-to-side anastomosis of the lesser curvature of stomach and jejunum by utilization of linear stapler in LRYGB from April 2012 to July 2015 were retrospectively analyzed. RESULTS: All patients were successfully completed laparoscopic gastric bypass with the side-to-side anastomosis of the lesser curvature of stomach and jejunum...
October 7, 2016: World Journal of Gastroenterology: WJG
Mayuree Kanlayavattanakul, Nattaya Lourith, Puxvadee Chaikul
ETHNOPHARMACOLOGICAL RELEVANCE: While rice is one of the most important global staple food sources its extracts have found many uses as the bases of herbal remedies. Rice extracts contain high levels of phenolic compounds which are known to be bioactive, some of which show cutaneous benefits and activity towards skin disorders. This study highlights an assessment of the cellular activity and clinical efficacy of rice panicle extract, providing necessary information relevant to the development of new cosmetic products...
October 6, 2016: Journal of Ethnopharmacology
Ki Won Lee, Hyung Won Ryu, Sang-Seok Oh, Soojong Park, Hamadi Madhi, Jiyun Yoo, Ki-Hun Park, Kwang Dong Kim
Melanogenesis is a key pathway for the regulation of skin pigmentation and the development of skin-lightening/whitening drugs or cosmetics. In this study, we found that β-mangostin from seedcases of Garcinia mangostana inhibited α-melanocyte-stimulating hormone (α-MSH)-mediated melanogenesis in B16F10 melanoma cells and a three-dimensional human skin model. β-Mangostin significantly inhibited the protein level of tyrosinase induced by α-MSH in UPS (ubiquitin proteasome system)-independent and lysosome-dependent manner...
October 7, 2016: Experimental Dermatology
Carlo Romagnoli, Anna Baldisserotto, Chiara B Vicentini, Donatella Mares, Elisa Andreotti, Silvia Vertuani, Stefano Manfredini
In this work, we evaluated the antidermatophytic activities of three resorcinol derivatives that have a history of use in dermo-cosmetic applications to discover molecules with multiple dermatological activities (i.e., multi-target drugs), thereby reducing the cost and time necessary for new drug development. The antidermatophytic activities of the three skin lighteners were evaluated relative to the known antifungal drug fluconazole on nine dermatophytes responsible for the most common dermatomycoses: Microsporum gypseum, Microsporum canis, Trichophyton violaceum, Arthroderma cajetani, Trichophyton mentagrophytes, Epidermophyton floccosum, Nannizzia gypsea, Trichophyton rubrum and Trichophyton tonsurans...
September 30, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Solomon Hailemeskel, Asrate Demissie, Nigussie Assefa
BACKGROUND: Primary dysmenorrhea (PD) is the most common gynecologic compliant among adolescent females. There is a wide variation in the estimate of PD, which ranges from 50% to 90%, and the disorder is the most common cause of work and school absenteeism in adolescent females. OBJECTIVE: To assess the prevalence and associated risk factors of PD among female university students and understand its effects on students' academic performance. METHODS: A cross-sectional study was employed in 440 research participants...
2016: International Journal of Women's Health
Roberto Solazzo, Michele Donati, Licia Tomasi, Filippo Arfini
Agriculture contributes significantly to greenhouse gas (GHG) emissions, accounting for more than 10% of total CO2 emissions in the EU-28 area. The Common Agricultural Policy (CAP) plays an important role in promoting environmentally and climate friendly practices and needs to respond to the new environmental challenges by better integrating its objectives with other EU policies. In this respect, the recent CAP reform 2014-2020 made a further step, making a large part of direct payments conditional on new agricultural practices beneficial for the climate and the environment, i...
September 29, 2016: Science of the Total Environment
Kamille-Amalie Bahn, Merete Hædersdal, Grethe Schmidt, Lisbet Rosenkrantz Hölmich
Congenital melanocytic naevi (CMN) appear in approximately 2.6% of Caucasians. There is a major demand for treatment but no vital indication. Laser therapy, curettage and excision are available treatment modalities, but there is no ideal treatment with documented long-term effect and without side effects, and the level of evidence for the treatment options is generally low. The risk of malignancy has probably been overestimated, and furthermore new research shows that untreated CMN often show spontaneous lightening...
September 19, 2016: Ugeskrift for Laeger
María-Antonia Pastor-Nieto, Paloma Sánchez-Pedreño, Teresa Martínez-Menchón, Virginia Melgar-Molero, Francisco Alcántara-Nicolás, Pablo de la Cruz-Murie
No abstract text is available yet for this article.
October 2016: Contact Dermatitis
Binghui Zheng, Yingqun Ma, Yanwen Qin, Lei Zhang, Yanmin Zhao, Wei Cao, Chenchen Yang, Chaonan Han
Water samples were collected from wastewater treatment plant (WWTP), drain water (DW), major tributaries (MT), and main course of the Yangtze River (MY) in areas of three industrial parks (IPs) in Chongqing city in the Three Gorges Reservoir (TGR). Sixteen EPA priority polycyclic aromatic hydrocarbon (PAH) pollutants were quantified to identify the effects of industrial activities on water quality of the TGR. The results showed that 11 individual PAHs were quantified and 5 PAHs (naphthalene (Nap), acenaphthylene (Acy), benzo[k]fluoranthene (BkF), indeno[1,2,3-cd]pyrene (InP), and benzo[g,h,i]perylene (BgP)) were under detection limits in all of the water samples...
September 10, 2016: Environmental Science and Pollution Research International
Ayodeji O Falade, Uchechukwu U Nwodo, Benson C Iweriebor, Ezekiel Green, Leonard V Mabinya, Anthony I Okoh
Ligninolytic extracellular enzymes, including lignin peroxidase, are topical owing to their high redox potential and prospective industrial applications. The prospective applications of lignin peroxidase span through sectors such as biorefinery, textile, energy, bioremediation, cosmetology, and dermatology industries. The litany of potentials attributed to lignin peroxidase is occasioned by its versatility in the degradation of xenobiotics and compounds with both phenolic and non-phenolic constituents. Over the years, ligninolytic enzymes have been studied however; research on lignin peroxidase seems to have been lagging when compared to other ligninolytic enzymes which are extracellular in nature including laccase and manganese peroxidase...
September 7, 2016: MicrobiologyOpen
Matthew Limb
No abstract text is available yet for this article.
2016: BMJ: British Medical Journal
Eric K W Wong, Muhammad N Mahmood, Thomas G Salopek
Congenital melanocytic nevi (CMNs) naturally evolve throughout life, growing proportionately with the child, darkening, and exhibiting textural or surface changes (e.g., papillomatous, verrucous, cerebriform), hypertrichosis, and, later in life, lightening of pigmentation. We report the case of a 5-year-old child with complete resolution of a medium-sized CMN involving the distal left leg and foot via sclerosis and in the absence of any halo phenomenon. Spontaneous regression of CMN via sclerosis is rare, and it is thought that an immunologic mechanism different from the mechanism that the halo phenomenon induces mediates this regression...
August 30, 2016: Pediatric Dermatology
M Ndiaye, M Taleb, B A Diatta, A Diop, M Diallo, S Diadie, N B Seck, S Diallo, M T Ndiaye, S O Niang, F Ly, A Kane, M T Dieng
INTRODUCTION: The etiologies of intertrigo in adults are numerous and different. The objective of our work was to study the epidemiological, clinical and the risk factors of intertrigo in adults. METHODS: We conducted a prospective study for a period of seven months in two Dermatology Units in Dakar (Senegal). All adults patient with intertrigo seen during this period who gave consent were included. RESULTS: One hundred and three patients with intertrigo were diagnosed with a hospital prevalence of 2...
August 20, 2016: Journal de Mycologie Médicale
Francesco Ricci, Clara De Simone, Laura Del Regno, Ketty Peris
Hair colour modifications comprise lightening/graying, darkening, or even a complete hair colour change, which may involve the scalp and/or all body hair. Systemic medications may cause hair loss or hypertrichosis, while hair colour change is an uncommon adverse effect. The rapidly increasing use of new target therapies will make the observation of these side effects more frequent. A clear relationship between drug intake and hair colour modification may be difficult to demonstrate and the underlying mechanisms of hair changes are often unknown...
August 19, 2016: European Journal of Dermatology: EJD
Huiying Luo, Rongrong Cao, Lijuan Wang, Lijuan Zhu
Cistanoside A (C. A) was one of phenylethanol glycosides isolated from Cistanche deserticola, a tonic in traditional Chinese medicine. In our previous research, we demonstrated that Cistanoside A (C. A) possess the protective activities on CCl4 induced hepatotoxicity in mice, such as increasing free radicals clearing activities, alleviating lipid-overoxidation damage, and improving respiratory chain function in mitochondria. Meanwhile, our previous research also demonstrated C.A possess protective activities on alcohol induced hepatotoxicity in mice, shown in ameliorate the hepatic function indices, lightening steatosis and inflammatory infiltration, increasing free radicals clearing activities, alleviating lipid-overoxidation damage, and alleviating energy metabolism in mitochondria...
August 18, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Mariko Matsumoto, Hiroaki Todo, Takumi Akiyama, Mutsuko Hirata-Koizumi, Kenji Sugibayashi, Yoshiaki Ikarashi, Atsushi Ono, Akihiko Hirose, Kazuhito Yokoyama
Following reports on potential risks of hydroquinone (HQ), HQ for skin lightening has been banned or restricted in Europe and the US. In contrast, HQ is not listed as a prohibited or limited ingredient for cosmetic use in Japan, and many HQ cosmetics are sold without restriction. To assess the risk of systemic effects of HQ, we examined the rat skin permeation rates of four HQ (0.3%, 1.0%, 2.6%, and 3.3%) cosmetics. The permeation coefficients ranged from 1.2 × 10(-9) to 3.1 × 10(-7) cm/s, with the highest value superior than the HQ aqueous solution (1...
August 10, 2016: Regulatory Toxicology and Pharmacology: RTP
Lester M Davids, Jennifer C Van Wyk, Nonhlanhla P Khumalo
Glutathione (GSH) is the most abundant naturally occurring non-protein thiol that protects mammalian cells from oxidative stress. Intravenous (IV) GSH for skin lightening is advertised by clinics in South Africa and internationally online, yet to date no published review on the subject exists. Methods. We conducted a MEDLINE search (to 30 September 2015) of GSH use for skin lightening and of all indications in medicine, to evaluate its safety. Results. Two controlled clinical trials (GSH capsules: 60 patients; 2% glutathione disulphide lotion: 30 patients) and a case series (GSH lozenges: 30 patients) reported a significantly decreased melanin index...
August 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Liwen Yan, Jingjing Hui, Yiran Liu, Yuehua Guo, Lu Liu, Lin Ding, Huangxian Ju
An intracellular cascade amplification strategy for ultrasensitive "off-on" imaging of telomerase activity in living cells was designed. The method was based on fabrication of a dual function module-encapsulated liposome nanoprobe, which consisted of a telomerase-targeting responder-transmitter DNA complex (HPT) module and a catalyzed hairpin assembly (CHA) signal amplification module. Upon transfected into living cells, the released HPT could be specifically recognized and extended by telomerase, leading to the release of the transmitter DNA...
December 15, 2016: Biosensors & Bioelectronics
Viviane M Saito, Marcus L Brandão
Recent discussions on the ethics in animal experimentation instigate the refinement of methods used in Behavioral Neuroscience, particularly regarding fear/anxiety paradigms. We propose the Light Switch-Off Test (LSOT), based on the innate motivation to cease an aversive stimulus (bright light), displayed naturally by rodents in their habitat. Forty-six male adult Wistar rats were allocated into independent groups: control, Diazepam at 1 or 2mg/kg, and meta-Chlorophenylpiperazine (mCPP) at 0.5 or 1mg/kg. The experimental box has two square compartments, separated by an acrylic portal...
August 2, 2016: Neuroscience
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