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https://www.readbyqxmd.com/read/28339980/pushing-the-limits-establishing-an-ultra-low-framerate-and-antiscatter-grid-less-radiation-protocol-for-left-atrial-ablations
#1
Philipp Attanasio, Tobias Schreiber, Burkert Pieske, Florian Blaschke, Leif-Hendrik Boldt, Wilhelm Haverkamp, Martin Huemer
Aims: Despite the use of 3D mapping systems and new developments of non-fluoroscopic options, most centres still rely at least in part on fluoroscopy for catheter visualization during catheter ablations. The purpose of this study was to assess the feasibility of using an ultra-low frame rate and antiscatter grid-less radiation protocol during complex left atrial ablations to minimize radiation exposure for the patient and staff. Methods and results: A total of 150 consecutive patients undergoing left atrial ablations in our hospital were included in the analysis...
March 4, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28338698/thermally-driven-bubble-evolution-at-a-heater-wire-in-water-characterized-by-high-speed-transmission-electron-microscopy
#2
J R Vance, S J Dillon
This work investigates the early stage evolution of thermally nucleated microbubbles in water using in situ high-speed, 400 fps, transmission electron microscopy. A Pt wire Joule heater induced bubble nucleation and growth from air-saturated water at different levels of power. For all powers below Pt breakdown, the dissolved gas initiates bubble nucleation at the concave surface defects adjacent to the area of highest temperature. A combination of interfacial forces and stress relaxation drive rapid migration of the bubbles away from the nucleation site...
March 24, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28336060/recent-advances-in-development-of-genetically-encoded-fluorescent-sensors
#3
Lynn Sanford, Amy Palmer
Genetically encoded fluorescent sensors are essential tools in modern biological research, and recent advances in fluorescent proteins (FPs) have expanded the scope of sensor design and implementation. In this review we compare different sensor platforms, including Förster resonance energy transfer (FRET) sensors, fluorescence-modulated single FP-based sensors, translocation sensors, complementation sensors, and dimerization-based sensors. We discuss elements of sensor design and engineering for each platform, including the incorporation of new types of FPs and sensor screening techniques...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28327082/out-of-hours-care-in-germany-high-utilization-by-adult-patients-with-minor-ailments
#4
R Leutgeb, P Engeser, S Berger, J Szecsenyi, G Laux
BACKGROUND: Family practitioners (FPs) who work in Out-Of-Hours Care (OOHC) - especially in rural areas - complain about high workload related to low urgency and potentially unnecessary patient presentations with minor ailments. The aim of this study was to describe Reasons for Encounter (RFEs) in primary OOHC taken into account the doctor's perspective in the context of high workload without knowing patients' motives for visiting an OOHC-centre. METHODS: Within this descriptive study, OOHC data from 2012 were evaluated from a German statutory health insurance company in the federal state of Baden-Wuerttemberg...
March 21, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28326860/latvian-family-physicians-experience-diagnosing-depression-in-somatically-presenting-depression-patients-a-qualitative-study
#5
Maija S Leff, Jeļena Vrubļevska, Agita Lūse, Elmārs Rancāns
BACKGROUND: Depression continues to be under-diagnosed in primary care settings. One factor that influences physicians' likelihood of diagnosing depression is patients' presentation style. Patients who initially present with somatic symptoms are diagnosed at a lower rate and with greater delay than patients who present with psychosocial complaints. OBJECTIVES: To identify the barriers preventing depression diagnosis in somatically presenting patients in an Eastern European primary care setting...
December 2017: European Journal of General Practice
https://www.readbyqxmd.com/read/28303397/association-of-the-baltic-sea-and-mediterranean-diets-with-indices-of-sarcopenia-in-elderly-women-osptre-fps-study
#6
Masoud Isanejad, Joonas Sirola, Jaakko Mursu, Toni Rikkonen, Heikki Kröger, Marjo Tuppurainen, Arja T Erkkilä
PURPOSE: To examine whether higher adherence to Baltic Sea diet (BSD) and Mediterranean diet (MED) have beneficial association with sarcopenia indices in elderly women. METHODS: In total 554 women, aged 65-72 years belonging to OSTPRE-FPS study answered a questionnaire on lifestyle factors and 3-day food record at baseline in 2002. Food consumptions and nutrient intakes were calculated. Nine components were selected to calculate BSD score. MED score was calculated using eight components...
March 16, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28299031/continuity-of-care-evaluation-the-view-of-patients-and-professionals-about-urban-family-physician-program
#7
Vahid Kohpeima Jahromi, Mohammad Hossein Mehrolhassani, Reza Dehnavieh, Hosein Saberi Anari
BACKGROUND: A responsibility of the family physician (FP) and one of the four aspects of the delivery of primary care services is continuity of care (COC). This study aimed to determine the COC of health care in urban health centers. METHODS: Between September 2015 and March 2016, we conducted a cross-sectional study using Primary Care Evaluation Tool questionnaires with multistage stratified cluster sample of FPs (n = 141) and patients (n = 710) in two provinces in Iran, Fars and Mazandaran...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28297452/an-epid-based-system-for-gantry-resolved-mlc-quality-assurance-for-vmat
#8
Benjamin J Zwan, Michael P Barnes, Todsaporn Fuangrod, Cameron J Stanton, Daryl J O'Connor, Paul J Keall, Peter B Greer
Multileaf collimator (MLC) positions should be precisely and independently measured as a function of gantry angle as part of a comprehensive quality assurance (QA) program for volumetric-modulated arc therapy (VMAT). It is also ideal that such a QA program has the ability to relate MLC positional accuracy to patient-specific dosimetry in order to determine the clinical significance of any detected MLC errors. In this work we propose a method to verify individual MLC trajectories during VMAT deliveries for use as a routine linear accelerator QA tool...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297438/technical-note-a-respiratory-monitoring-and-processing-system-based-on-computer-vision-prototype-and-proof-of-principle
#9
Nicolas Leduc, Vincent Atallah, Patrick Escarmant, Vincent Vinh-Hung
Monitoring and controlling respiratory motion is a challenge for the accuracy and safety of therapeutic irradiation of thoracic tumors. Various commercial systems based on the monitoring of internal or external surrogates have been developed but remain costly. In this article we describe and validate Madibreast, an in-house-made respiratory monitoring and processing device based on optical tracking of external markers. We designed an optical apparatus to ensure real-time submillimetric image resolution at 4 m...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28287596/generation-of-fluorescent-protein-fusions-in-candida-species
#10
Sara Gonia, Judith Berman, Cheryl A Gale
Candida species, prevalent colonizers of the intestinal and genitourinary tracts, are the cause of the majority of invasive fungal infections in humans. Thus, molecular and genetic tools are needed to facilitate the study of their pathogenesis mechanisms. PCR-mediated gene modification is a straightforward and quick approach to generate epitope-tagged proteins to facilitate their detection. In particular, fluorescent protein (FP) fusions are powerful tools that allow visualization and quantitation of both yeast cells and proteins by fluorescence microscopy and immunoblotting, respectively...
March 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28287449/a-physical-activity-reference-data-set-recorded-from-older-adults-using-body-worn-inertial-sensors-and-video-technology-the-adapt-study-data-set
#11
Alan Kevin Bourke, Espen Alexander F Ihlen, Ronny Bergquist, Per Bendik Wik, Beatrix Vereijken, Jorunn L Helbostad
Physical activity monitoring algorithms are often developed using conditions that do not represent real-life activities, not developed using the target population, or not labelled to a high enough resolution to capture the true detail of human movement. We have designed a semi-structured supervised laboratory-based activity protocol and an unsupervised free-living activity protocol and recorded 20 older adults performing both protocols while wearing up to 12 body-worn sensors. Subjects' movements were recorded using synchronised cameras (≥25 fps), both deployed in a laboratory environment to capture the in-lab portion of the protocol and a body-worn camera for out-of-lab activities...
March 10, 2017: Sensors
https://www.readbyqxmd.com/read/28284330/inhibition-of-ages-rage-rho-rock-pathway-suppresses-non-specific-neuroinflammation-by-regulating-bv2-microglial-m1-m2-polarization-through-the-nf-%C3%AE%C2%BAb-pathway
#12
Jingkao Chen, Zhaowei Sun, Minghua Jin, Yalin Tu, Shengnan Wang, Xiaohong Yang, Qiuhe Chen, Xiao Zhang, Yifan Han, Rongbiao Pi
The microglia-mediated neuroinflammation plays an important role in the pathogenesis of Alzheimer's disease (AD). Advanced glycation end products (AGEs)/receptor for advanced glycation end products (RAGE) or Rho/Rho kinase (ROCK) are both involved in the development of non-specific inflammation. However, there are few reports about their effects on neuroinflammation. Here, we explored the mechanism of AGEs/RAGE/Rho/ROCK pathway underlying the non-specific inflammation and microglial polarization in BV2 cells...
April 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28270862/the-polypharmacology-browser-a-web-based-multi-fingerprint-target-prediction-tool-using-chembl-bioactivity-data
#13
Mahendra Awale, Jean-Louis Reymond
BACKGROUND: Several web-based tools have been reported recently which predict the possible targets of a small molecule by similarity to compounds of known bioactivity using molecular fingerprints (fps), however predictions in each case rely on similarities computed from only one or two fps. Considering that structural similarity and therefore the predicted targets strongly depend on the method used for comparison, it would be highly desirable to predict targets using a broader set of fps simultaneously...
2017: Journal of Cheminformatics
https://www.readbyqxmd.com/read/28270223/biomechanical-characteristics-of-fixation-methods-for-floating-pubic-symphysis
#14
Wenhao Song, Dongsheng Zhou, Yu He
BACKGROUND: Floating pubic symphysis (FPS) is a relatively rare injury caused by high-energy mechanisms. There are several fixation methods used to treat FPS, including external fixation, subcutaneous fixation, internal fixation, and percutaneous cannulated screw fixation. To choose the appropriate fixation, it is necessary to study the biomechanical performance of these different methods. The goal of this study was to compare the biomechanical characteristics of six methods by finite element analysis...
March 7, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28269344/inductive-power-transmission-to-millimeter-sized-biomedical-implants-using-printed-spiral-coils
#15
Ahmed Ibrahim, Mehdi Kiani
The operation frequency (f) has been a key parameter in optimizing wireless power transmission links for biomedical implants with millimeter (mm) dimensions. This paper studies the feasibility of using printed spiral coils (PSCs) for powering mm-sized implants with high power transmission efficiency (PTE) at different fps. Compared to wire-wound coils (WWCs), using a PSC in the implant side allows batch fabrication on rigid or flexible substrates, which can also be used as a platform for integrating implant components...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268999/high-speed-in-vivo-imaging-of-retinal-hemodynamics-in-a-rodent-model-of-hypertension
#16
Mahdieh Rezaeian, Dana Georgevsky, S Mojtaba Golzan, Stuart L Graham
The eye is the only organ through which microcirculation can be visualized non-invasively. This unique feature makes the eye and specifically retinal vasculature an excellent target area to monitor and study micro-vascular damage in systemic diseases. Dynamic (real-time) changes of retinal vessels have been shown to be more specific to the disease in comparison with static measurements. In this study we utilize high speed imaging (i.e. 125 fps) to study and derive dynamic changes of retinal vessels in a rat model of hypertension...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268510/simplified-computer-aided-detection-scheme-of-microcalcification-clusters-in-digital-breast-tomosynthesis-images
#17
Ji-Wook Jeong, Seung-Hoon Chae, Eun Young Chae, Hak Hee Kim, Young Wook Choi, Sooyeul Lee
A computer-aided detection (CADe) algorithm for clustered microcalcifications (MCs) in reconstructed digital breast tomosynthesis (DBT) images is suggested. The MC-like objects were enhanced by a Hessian-based 3D calcification response function, and a signal-to-noise ratio (SNR) enhanced image was also generated to screen the MC clustering seed objects. A connected component segmentation method was used to detect the cluster seed objects, which were considered as potential clustering centers of MCs. Bounding cubes for the accepted clustering seed candidate were generated and the overlapping cubes were combined and examined...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28264527/the-theoretical-highest-frame-rate-of-silicon-image-sensors
#18
Takeharu Goji Etoh, Anh Quang Nguyen, Yoshinari Kamakura, Kazuhiro Shimonomura, Thi Yen Le, Nobuya Mori
The frame rate of the digital high-speed video camera was 2000 frames per second (fps) in 1989, and has been exponentially increasing. A simulation study showed that a silicon image sensor made with a 130 nm process technology can achieve about 1010 fps. The frame rate seems to approach the upper bound. Rayleigh proposed an expression on the theoretical spatial resolution limit when the resolution of lenses approached the limit. In this paper, the temporal resolution limit of silicon image sensors was theoretically analyzed...
February 28, 2017: Sensors
https://www.readbyqxmd.com/read/28260662/addition-of-fish-pond-sediment-and-rock-phosphate-enhances-the-composting-of-green-waste
#19
Lu Zhang, Xiangyang Sun
The objective of this work was to study the two-stage composting of green waste (GW) as affected by addition of fish pond sediment (FPS; at 0, 25, and 35%) and/or rock phosphate (RP; at 0, 10, and 15%). The combined addition of FPS and RP greatly accelerated GW degradation and improved compost quality in terms of composting temperature, windrow volume, pH, electrical conductivity (EC), cation exchange capacity (CEC), NH3 emission, microbial biomass, enzyme activities, nutrient content, and seed germination...
February 20, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28257651/care-coordination-for-children-with-special-health-care-needs-a-cohort-study
#20
Elisa Zanello, Simona Calugi, Lee M Sanders, Jacopo Lenzi, Giacomo Faldella, Paola Rucci, Maria Pia Fantini
BACKGROUND: Care coordination is widely recognized as a key element of care for patients with chronic and complex medical conditions and their families. In care for children with special health care needs the Family Pediatrician (FP) plays a central role as care coordinator. This study aims to evaluate the FPs' activities of care coordination for children with special health care needs in the pediatric primary care setting, using an on-line measurement tool. METHODS: Within the prospective cohort study SpeNK (Special Needs Kids), newborns and children with special health care needs were recruited at discharge from three hospital facilities in Bologna province, from October 1st 2012 to September 30th 2014...
February 3, 2017: Italian Journal of Pediatrics
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