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Xin Xue, Xingxing Chen, Weili Fan, Guan Wang, Liang Zhang, Zongfeng Chen, Peng Liu, Mingyong Liu, Jianhua Zhao
High-mobility group box 1 (HMGB1) facilitates neural stem cells (NSCs) proliferation and differentiation into neuronal linage. However, the effect of HMGB1 on NSCs migration is still elusive. The present study is to investigate the corelation between HMGB1 and NSCs migration and the potential mechanism. The results indicated that 1 ng/ml HMGB1 promoted NSCs proliferation using CCK8 assays. Moreover, data showed that 1 ng/ml HMGB1 facilitated NSCs migration via filopodia formation using phase-contrast and transwell assays...
March 14, 2018: Scientific Reports
Hein Heidbuchel, Nikolaos Dagres, Matthias Antz, Karl-Heinz Kuck, Patrice Lazure, Suzanne Murray, Céline Carrera, Gerhard Hindricks, Alec Vahanian
Aims: Guideline-adherent treatment is associated with improved prognosis in atrial fibrillation (AF) patients but is insufficiently implemented in clinical practice. The European Society of Cardiology (ESC) performed a multinational educational needs assessment study among cardiologists, general practitioners/family physicians (GPs/FPs), and neurologists in order to evaluate knowledge and skills of physicians and system factors related to AF care delivery. Methods and results: A total of 561 physicians (294 cardiologists, 131 neurologists, and 136 GPs/FPs) from six European countries participated...
March 12, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Michael R Kolber, Shelley Ross
BACKGROUND AND OBJECTIVES: In Canada, few family physicians (FPs) perform endoscopy. Conflicting evidence exists on the quality of endoscopy performed by Canadian FPs, which may be explained by differing skillsets of these endoscopists. The objective of this study was to perform the first exploration of the practice, skills, and knowledge of Canadian FP endoscopists. METHODS: A cross-sectional survey, including direct knowledge test, was used. RESULTS: Twenty Canadian FP endoscopists completed the survey...
March 2018: Family Medicine
Marion Semmler, Michael Döllinger, Rita R Patel, Anke Ziethe, Anne Schützenberger
OBJECTIVE/HYPOTHESIS: Laser-based three-dimensional (3D) imaging allows realistic visualization and absolute measurement of the vocal folds for comprehensive characterization of the oscillation pattern. STUDY DESIGN: Exploratory study with descriptive data analysis in healthy cohort. METHODS: The custom-developed miniaturized measuring device is an endoscopic camera-laser setup for stereo triangulation and suitable for in vivo application...
March 14, 2018: Laryngoscope
Giuseppe Placidi, Luigi Cinque, Matteo Polsinelli, Matteo Spezialetti
Hand rehabilitation is fundamental after stroke or surgery. Traditional rehabilitation requires a therapist and implies high costs, stress for the patient, and subjective evaluation of the therapy effectiveness. Alternative approaches, based on mechanical and tracking-based gloves, can be really effective when used in virtual reality (VR) environments. Mechanical devices are often expensive, cumbersome, patient specific and hand specific, while tracking-based devices are not affected by these limitations but, especially if based on a single tracking sensor, could suffer from occlusions...
March 10, 2018: Sensors
Andrea Piazzoli, Florian Breider, Caroline Gachet Aquillon, Manuela Antonelli, Urs von Gunten
N-nitrosamines are a group of potent human carcinogens that can be formed during oxidative treatment of drinking water and wastewater. Many tertiary and quaternary amines present in consumer products (e.g., pharmaceuticals, personal care and household products) are known to be N-nitrosodimethylamine (NDMA) precursors during chloramination, but the formation of other N-nitrosamines has been rarely studied. This study investigates the specific and total N-nitrosamine (TONO) formation potential (FP) of various precursors from nitrogen-containing micropollutants (chlorhexidine, metformin, benzalkonium chloride and cetyltrimethylammonium chloride) and tertiary and quaternary model amines (trimethyl amine, N,N-dimethylbutyl amine, N,N-dimethylbenzyl amine and tetramethyl ammonium)...
February 10, 2018: Water Research
Lixia Ni, Zhenxing Li, Haifeng Li, Xu Liu
This paper proposes a 360-deg large-scale multiprojection light-field 3D display system, which can reconstruct the light field of models in real space. The reconstructed contents can be observed by multiple viewers from different angles and positions simultaneously. In this system, 360 projectors project images onto a cylindrical light-field diffusion screen whose height is 1.8 m and diameter is 3 m. When moving around the system, viewers can see 3D scenes with smooth-motion parallax, and the frame rate can reach 30 fps and above...
March 10, 2018: Applied Optics
Andreia C Freitas, Matthieu Ruthven, Redha Boubertakh, Marc E Miquel
PURPOSE: This study aims to improve clinical reliability of real-time Magnetic Resonance Imaging (rt-MRI) in the visualisation of velopharyngeal motion during speech. METHODS: Seven subjects were imaged at 3T during natural phonation. Speech rt-MRI methodologies were investigated with (i) a comparison of commercial Cartesian and non-Cartesian (radial and spiral) rt-MRI sequences and (ii) investigation of further improvement with accelerated radial acquisition and offline reconstruction methodology...
February 2018: Physica Medica: PM
Juan Song, Fei Yin, Xia Li, Na Dong, Yingjie Zhu, Yanan Shao, Baoli Chen, Wei Jiang, Chen-Zhong Li
We developed a novel approach to determine formamidopyrimidine DNA glycosylase (FPG) activity by taking advantage of target-induced self-primed rolling circle amplification (RCA) and magnetic nanoprobes. Herein, a unique nick (8-oxoguanine, 8-oxoG) was positioned in duplex DNA containing P-circle and P1 , which together serve as a FPG substrate, RCA template, and RCA primer probe. The presence of FPG specifically binds 8-oxoG and cleaves the P-circle into two parts, producing 5'-phosphoryl termini. A phosphodiester bond between the 5'-phosphoryl and 3'-hydroxyl termini was formed with the addition of T4 DNA ligase, producing an unnicked circular strand...
March 8, 2018: Analyst
Cosmas Mwikirize, John L Nosher, Ilker Hacihaliloglu
PURPOSE: We propose a framework for automatic and accurate detection of steeply inserted needles in 2D ultrasound data using convolution neural networks. We demonstrate its application in needle trajectory estimation and tip localization. METHODS: Our approach consists of a unified network, comprising a fully convolutional network (FCN) and a fast region-based convolutional neural network (R-CNN). The FCN proposes candidate regions, which are then fed to a fast R-CNN for finer needle detection...
March 6, 2018: International Journal of Computer Assisted Radiology and Surgery
A Dang, S Miller, D Horvat, T Klassen-Ross, M Graveline, R Collins, R Olson
Background: Across our province, post-radiotherapy (rt) handover notes are sent to family physicians (fps) after rt. Based on previous fp feedback, we created a revised post-radiotherapy handover note with more information requested by fps. The purpose of this study was to determine whether the revised handover note improved the note as a communication aid. Methods: Potential common and rare treatment side effects, oncologist contact information, and treatment intent were added to the revised handover note...
February 2018: Current Oncology
Xiaoqing Gao, Francesco Gentile, Bruno Rossion
Defining the neural basis of perceptual categorization in a rapidly changing natural environment with low-temporal resolution methods such as functional magnetic resonance imaging (fMRI) is challenging. Here, we present a novel fast periodic stimulation (FPS)-fMRI approach to define face-selective brain regions with natural images. Human observers are presented with a dynamic stream of widely variable natural object images alternating at a fast rate (6 images/s). Every 9 s, a short burst of variable face images contrasting with object images in pairs induces an objective face-selective neural response at 0...
March 3, 2018: Brain Structure & Function
Zhimei Lv, Mengsi Hu, Minghua Fan, Xiaobing Li, Jiangong Lin, Junhui Zhen, Ziyang Wang, Haijun Jin, Rong Wang
Activation of Ras-related C3 botulinum toxin substrate 1 (Rac1) has been implicated in diverse kidney diseases, yet its in vivo significance in diabetic nephropathy (DN) is largely unknown. In the present study, we demonstrated a podocyte-specific Rac1-deficient mouse strain and showed that specific inhibition of Rac1 was able to attenuate diabetic podocyte injury and proteinuria by the blockade of Rac1/PAK1/p38/β-catenin signaling cascade, which reinstated the integrity of podocyte slit diaphragms (SD), rectified the effacement of foot processes (FPs), and prevented the dedifferentiation of podocytes...
March 1, 2018: Cell Death & Disease
Susana Rebelo, Sofia Velho Rua, Joana d'Orey Leça, Ana Couto, Rute Teixeira, João Firmino-Machado
OBJECTIVES: To determine if children attend the family physician (FP) or the FP/paediatrician for their surveillance medical appointments, as well as analyse the variables associated with the parents' choice between the two physicians. DESIGN: Cross-sectional study. SETTING: Public, semiprivate and private kindergartens in the city of Vila Nova de Famalicão (Portugal). PARTICIPANTS: Parents of children aged 6 years or less without chronic diseases, enrolled in the selected kindergartens...
March 1, 2018: BMJ Open
Syed Muhammad Naqi, Muhammad Sharif, Mussarat Yasmin
PURPOSE: Lung cancer detection at its initial stages increases the survival chances of patients. Automatic detection of lung nodules facilitates radiologists during the diagnosis. However, there is a challenge of false positives in automated systems which may lead to wrong findings. Precise segmentation facilitates to accurately extract nodules from lung CT images in order to improve performance of the diagnostic method. METHODS: A multistage segmentation model is presented in this study...
February 28, 2018: International Journal of Computer Assisted Radiology and Surgery
Ernest Usang Ekpo, Maram Alakhras, Patrick Brennan
Mammography has been the frontline screening tool for breast cancer for decades. However, high error rates in the form of false negatives (FNs) and false positives (FPs) have persisted despite technological improvements. Radiologists still miss between 10% and 30% of cancers while 80% of woman recalled for additional views have normal outcomes, with 40% of biopsied lesions being benign. Research show that the majority of cancers missed is actually visible and looked at, but either go unnoticed or are deemed to be benign...
February 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Beatriz Fornell, Manuel Correa, M Puerto López Del Amo, José J Martín
PURPOSE: We analyze the influence of the dramatic changes in the Spanish labor market during the crisis on the perceived health of the Spanish population. METHODS: We use the longitudinal Living Conditions Survey database and multilevel longitudinal logistic models between 2007 and 2011, before and during the economic crisis in one of the European countries most affected by its consequences. RESULTS: Unemployment (OR 1.75; p < 0.001), job insecurity (OR 1...
February 24, 2018: Quality of Life Research
Mahsa Akhbari, Nasim Montazeri Ghahjaverestan, Mohammad B Shamsollahi, Christian Jutten
In this paper, we propose a novel method for extracting fiducial points (FPs) of the beats in electrocardiogram (ECG) signals using switching Kalman filter (SKF). In this method, according to McSharry's model, ECG waveforms (P-wave, QRS complex and T-wave) are modeled with Gaussian functions and ECG baselines are modeled with first order auto regressive models. In the proposed method, a discrete state variable called "switch" is considered that affects only the observation equations. We denote a mode as a specific observation equation and switch changes between 7 modes and corresponds to different segments of an ECG beat...
April 2018: Computer Methods and Programs in Biomedicine
Catharina S de Jonge, Ruaridh M Gollifer, Aart J Nederveen, David Atkinson, Stuart A Taylor, Jaap Stoker, Alex Menys
OBJECTIVE: Dynamic imaging of small intestinal motility is an increasingly common research method to examine bowel physiology in health and disease. However, limited data exists to guide imaging protocols with respect to quantitative analysis. The purpose of this study is to define the required temporal resolution and scan duration in dynamic MRI for small bowel motility assessment. METHODS: 6 healthy volunteers underwent motility imaging with MR enterography using breath-hold protocol...
February 23, 2018: British Journal of Radiology
Jeong-Hyeon Kim, Kyeong-A Kim, Young-Jun Shin, Haram Kim, Arshad Majid, Ok-Nam Bae
Endothelial cells (ECs) maintain the structure and function of blood vessels and are readily exposed to exogenous and endogenous toxic substances in the circulatory system. Bone marrow-derived endothelial progenitor cells (EPCs) circulate in the blood and differentiate to EC, which are known to participate in angiogenesis and regeneration of injured vessels. Dysfunction in EPC contributes to cardiovascular complications in patients with diabetes, but the precise molecular mechanisms underlying diabetic EPC abnormalities are not completely understood...
February 23, 2018: Journal of Toxicology and Environmental Health. Part A
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