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https://www.readbyqxmd.com/read/28540836/vocal-cord-paresis-following-single-session-high-intensity-focused-ablation-hifu-treatment-of-benign-thyroid-nodules-incidence-and-risk-factors
#1
Brian Hh Lang, Yu-Cho Woo, Keith Wan-Hang Chiu
BACKGROUND: Vocal cord paresis (VCP) may occur following high intensity focused ultrasound (HIFU) of thyroid nodules. We hypothesized its occurrence relates to the distance of the focus point (FP) of the HIFU beams from the recurrent laryngeal nerve (RLN) and the thermal power that this point received. Their relationships were examined. METHODS: One hundred and three patients who underwent HIFU for symptomatic benign thyroid nodule from October 2015 to March 2017 were analyzed...
May 24, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28530831/blue-shifted-green-fluorescent-protein-homologues-are-brighter-than-enhanced-green-fluorescent-protein-under-two-photon-excitation
#2
Rosana S Molina, Tam M Tran, Robert E Campbell, Gerard G Lambert, Anya Salih, Nathan C Shaner, Thomas E Hughes, Mikhail Drobizhev
Fluorescent proteins (FPs) are indispensable markers for two-photon imaging of live tissue, especially in the brains of small model organisms. The quantity of physiologically relevant data collected, however, is limited by heat-induced damage of the tissue due to the high intensities of the excitation laser. We seek to minimize this damage by developing FPs with improved brightness. Among FPs with the same chromophore structure, the spectral properties can vary widely due to differences in the local protein environment...
May 25, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28524850/a-high-quantum-yield-molecule-protein-complex-fluorophore-for-near-infrared-ii-imaging
#3
Alexander L Antaris, Hao Chen, Shuo Diao, Zhuoran Ma, Zhe Zhang, Shoujun Zhu, Joy Wang, Alexander X Lozano, Quli Fan, Leila Chew, Mark Zhu, Kai Cheng, Xuechuan Hong, Hongjie Dai, Zhen Cheng
Fluorescence imaging in the second near-infrared window (NIR-II) allows visualization of deep anatomical features with an unprecedented degree of clarity. NIR-II fluorophores draw from a broad spectrum of materials spanning semiconducting nanomaterials to organic molecular dyes, yet unfortunately all water-soluble organic molecules with >1,000 nm emission suffer from low quantum yields that have limited temporal resolution and penetration depth. Here, we report tailoring the supramolecular assemblies of protein complexes with a sulfonated NIR-II organic dye (CH-4T) to produce a brilliant 110-fold increase in fluorescence, resulting in the highest quantum yield molecular fluorophore thus far...
May 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28490923/multigene-expression-profile-testing-in-breast-cancer-is-there-a-role-for-family-physicians
#4
M A O'Brien, J C Carroll, D P Manca, B Miedema, P A Groome, T Makuwaza, J Easley, N Sopcak, L Jiang, K Decker, M L McBride, R Moineddin, J A Permaul, R Heisey, E A Eisenhauer, M K Krzyzanowska, S Pruthi, C Sawka, N Schneider, J Sussman, R Urquhart, C Versaevel, E Grunfeld
BACKGROUND: Family physicians (fps) play a role in aspects of personalized medicine in cancer, including assessment of increased risk because of family history. Little is known about the potential role of fps in supporting cancer patients who undergo tumour gene expression profile (gep) testing. METHODS: We conducted a mixed-methods study with qualitative and quantitative components. Qualitative data from focus groups and interviews with fps and cancer specialists about the role of fps in breast cancer gep testing were obtained during studies conducted within the pan-Canadian canimpact research program...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490920/the-role-of-family-physicians-in-cancer-care-perspectives-of-primary-and-specialty-care-providers
#5
J Easley, B Miedema, M A O'Brien, J Carroll, D Manca, F Webster, E Grunfeld
BACKGROUND: Currently, the specific role of family physicians (fps) in the care of people with cancer is not well defined. Our goal was to explore physician perspectives and contextual factors related to the coordination of cancer care and the role of fps. METHODS: Using a constructivist grounded theory approach, we conducted telephone interviews with 58 primary and cancer specialist health care providers from across Canada. RESULTS: The participants-21 fps, 15 surgeons, 12 medical oncologists, 6 radiation oncologists, and 4 general practitioners in oncology-were asked to describe both the role that fps currently play and the role that, in their opinion, fps should play in the future care of cancer patients across the cancer continuum...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28486672/-meet-and-greet-intake-appointments-in-primary-care-a-new-pattern-of-patient-intakes
#6
Emily Gard Marshall, Imhokhai Ogah, Beverley Lawson, Richard J Gibson, Frederick Burge
Background.: Family physicians (FPs) are expected to take on new patients fairly and equitably and to not discriminate based on medical or social history. 'Meet and greet' appointments are initial meetings between physicians and prospective patients to establish fit between patient needs and provider scope of practice. The public often views these appointments as discriminatory; however, there is no empirical evidence regarding their prevalence or outcomes. Objectives...
May 9, 2017: Family Practice
https://www.readbyqxmd.com/read/28484475/de-novo-sequencing-and-transcriptome-analysis-reveal-key-genes-regulating-steroid-metabolism-in-leaves-roots-adventitious-roots-and-calli-of-periploca-sepium-bunge
#7
Jian Zhang, Xinglin Li, Fuping Lu, Shanying Wang, Yunhe An, Xiaoxing Su, Xiankuan Li, Lin Ma, Guangjian Han
Periploca sepium Bunge is a traditional medicinal plant, whose root bark is important for Chinese herbal medicine. Its major bioactive compounds are C21 steroids and periplocin, a kind of cardiac glycoside, which are derived from the steroid synthesis pathway. However, research on P. sepium genome or transcriptomes and their related genes has been lacking for a long time. In this study we estimated this species nuclear genome size at 170 Mb (using flow cytometry). Then, RNA sequencing of four different tissue samples of P...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28484064/family-physicians-report-considerable-interest-in-but-limited-use-of-telehealth-services
#8
Miranda A Moore, Megan Coffman, Anuradha Jetty, Kathleen Klink, Stephen Petterson, Andrew Bazemore
PURPOSE: Little is known about the attitudes toward and adoption of telehealth services among family physicians (FPs), the largest primary care physician group. We conducted a national survey of FPs, randomly sampled from membership organization files, to investigate use of and barriers to using telehealth services. METHODS: Using bivariate analyses, we examined how telehealth usage affected FPs' identified barriers to using telehealth services. Logistic regressions show the factors associated both with using telehealth services and with barriers to using telehealth services...
May 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28481303/interaction-of-biliverdin-chromophore-with-near-infrared-fluorescent-protein-bphp1-fp-engineered-from-bacterial-phytochrome
#9
Olesya V Stepanenko, Olga V Stepanenko, Irina M Kuznetsova, Daria M Shcherbakova, Vladislav V Verkhusha, Konstantin K Turoverov
Near-infrared (NIR) fluorescent proteins (FPs) designed from PAS (Per-ARNT-Sim repeats) and GAF (cGMP phosphodiesterase/adenylate cyclase/FhlA transcriptional activator) domains of bacterial phytochromes covalently bind biliverdin (BV) chromophore via one or two Cys residues. We studied BV interaction with a series of NIR FP variants derived from the recently reported BphP1-FP protein. The latter was engineered from a bacterial phytochrome RpBphP1, and has two reactive Cys residues (Cys15 in the PAS domain and Cys256 in the GAF domain), whereas its mutants contain single Cys residues either in the PAS domain or in the GAF domain, or no Cys residues...
May 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28477395/quantitative-comparison-of-clustered-microcalcifications-in-for-presentation-and-for-processing-mammograms-in-full-field-digital-mammography
#10
Juan Wang, Robert M Nishikawa, Yongyi Yang
PURPOSE: Mammograms acquired with full-field digital mammography (FFDM) systems are provided in both "for-processing" and "for-presentation" image formats. For-presentation images are traditionally intended for visual assessment by the radiologists. In this study, we investigate the feasibility of using for-presentation images in computerized analysis and diagnosis of microcalcification (MC) lesions. METHODS: We make use of a set of 188 matched mammogram image pairs of MC lesions from 95 cases (biopsy proven), in which both for-presentation and for-processing images are provided for each lesion...
May 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28467509/laryngeal-evidence-for-the-first-and-second-passaggio-in-professionally-trained-sopranos
#11
Matthias Echternach, Fabian Burk, Marie Köberlein, Andreas Selamtzis, Michael Döllinger, Michael Burdumy, Bernhard Richter, Christian Thomas Herbst
INTRODUCTION: Due to a lack of empirical data, the current understanding of the laryngeal mechanics in the passaggio regions (i.e., the fundamental frequency ranges where vocal registration events usually occur) of the female singing voice is still limited. MATERIAL AND METHODS: In this study the first and second passaggio regions of 10 professionally trained female classical soprano singers were analyzed. The sopranos performed pitch glides from A3 (ƒo = 220 Hz) to A4 (ƒo = 440 Hz) and from A4 (ƒo = 440 Hz) to A5 (ƒo = 880 Hz) on the vowel [iː]...
2017: PloS One
https://www.readbyqxmd.com/read/28466619/medical-clowns-and-cortisol-levels-in-children-undergoing-venipuncture-in-the-emergency-department-a-pilot-study
#12
Ayelet Rimon, Shelly Shalom, Ido Wolyniez, Alejandro Gruber, Anita Schachter-Davidov, Miguel Glatstein
BACKGROUND: Medical clowns are increasingly used for diminishing pain and anxiety during painful procedures being performed on children in the hospital setting. Cortisol levels rise as a response to emotional distress. OBJECTIVES: To investigate whether medical clown-assisted interventions to reduce child's distress during venipuncture have an effect on cortisol levels. METHODS: During a 1 year period, children requiring blood work or intravenous access in the pediatric emergency department were prospectively randomized to either the presence or absence of a medical clown during the procedure...
November 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28466029/global-detection-approach-for-clustered-microcalcifications-in-mammograms-using-a-deep-learning-network
#13
Juan Wang, Robert M Nishikawa, Yongyi Yang
In computerized detection of clustered microcalcifications (MCs) from mammograms, the traditional approach is to apply a pattern detector to locate the presence of individual MCs, which are subsequently grouped into clusters. Such an approach is often susceptible to the occurrence of false positives (FPs) caused by local image patterns that resemble MCs. We investigate the feasibility of a direct detection approach to determining whether an image region contains clustered MCs or not. Toward this goal, we develop a deep convolutional neural network (CNN) as the classifier model to which the input consists of a large image window ([Formula: see text] in size)...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28456859/a-comparison-of-visual-recognition-of-the-laryngopharyngeal-structures-between-high-and-standard-frame-rate-videos-of-the-fiberoptic-endoscopic-evaluation-of-swallowing
#14
Mehran Alizadeh Aghdam, Makoto Ogawa, Toshihiko Iwahashi, Kiyohito Hosokawa, Chieri Kato, Hidenori Inohara
The purpose of this study was to assess whether or not high frame rate (HFR) videos recorded using high-speed digital imaging (HSDI) improve the visual recognition of the motions of the laryngopharyngeal structures during pharyngeal swallow in fiberoptic endoscopic evaluation of swallowing (FEES). Five healthy subjects were asked to swallow 0.5 ml water under fiberoptic nasolaryngoscopy. The endoscope was connected to a high-speed camera, which recorded the laryngopharyngeal view throughout the swallowing process at 4000 frames/s (fps)...
April 29, 2017: Dysphagia
https://www.readbyqxmd.com/read/28456687/oxytocin-receptor-neurotransmission-in-the-dorsolateral-bed-nucleus-of-the-stria-terminalis-facilitates-the-acquisition-of-cued-fear-in-the-fear-potentiated-startle-paradigm-in-rats
#15
Mahsa Moaddab, Joanna Dabrowska
Oxytocin (OT) is a hypothalamic neuropeptide that modulates fear and anxiety-like behaviors. Dorsolateral bed nucleus of the stria terminalis (BNSTdl) plays a critical role in the regulation of fear and anxiety, and expresses high levels of OT receptor (OTR). However, the role of OTR neurotransmission within the BNSTdl in mediating these behaviors is unknown. Here, we used adult male Sprague-Dawley rats to investigate the role of OTR neurotransmission in the BNSTdl in the modulation of the acoustic startle response, as well as in the acquisition and consolidation of conditioned fear using fear potentiated startle (FPS) paradigm...
April 26, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28454597/time-trends-in-the-family-physician-management-of-insomnia-the-australian-experience-2000-2015
#16
Christopher B Miller, Lisa Valenti, Christopher M Harrison, Delwyn J Bartlett, Nick Glozier, Nathan E Cross, Ronald R Grunstein, Helena C Britt, Nathaniel S Marshall
STUDY OBJECTIVES: To evaluate changes in rates of family physician (FP) management of insomnia in Australia from 2000-2015. METHODS: The Bettering the Evaluation And Care of Health (BEACH) program is a nationally representative cross-sectional survey of 1,000 newly randomly sampled family physicians' activity in Australia per year, who each record details of 100 consecutive patient encounters. This provided records of approximately 100,000 encounters each year. We identified all encounters with patients older than 15 years where insomnia or difficulty sleeping was managed and assessed trends in these encounters from 2000-2015...
April 25, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28449717/a-review-of-patient-reported-outcome-measures-to-assess-female-infertility-related-quality-of-life
#17
REVIEW
Helen Kitchen, Natalie Aldhouse, Andrew Trigg, Roberto Palencia, Stephen Mitchell
BACKGROUND: Infertility has a negative impact on quality of life (QoL) and well-being of affected individuals and couples. A variety of patient-reported outcome (PRO) measures to assess infertility-related QoL are available; however, there is a concern regarding potential issues with their development methodology, validation and use. This review aimed to i) identify PRO measures used in infertility interventional studies ii) assess validation evidence to identify a reliable, valid PRO measure to assess changes in QoL or treatment satisfaction in clinical studies with female patients following treatment with novel therapies iii) identify potential gaps in evidence for validity...
April 27, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28431146/response-of-broiler-chickens-fed-wheat-based-diets-to-xylanase-supplementation
#18
G Gonzalez-Ortiz, D Sola-Oriol, M Martinez-Mora, J F Perez, M R Bedford
The objective of this study was to evaluate the effect of xylanase supplementation on performance, footpad score (FPS), nutrient digestibility, and intestinal morphometry in broiler chickens. Two-hundred-eighty-eight Ross 308 broiler chicks (one d old) were placed in one of 3 experimental treatments: positive control (PC), negative control (NC) (-150 kcal/kg), and XYL (NC supplemented with xylanase). Each treatment had 8 replicates with 12 animals each. Starter (zero to 21 d) and grower (21 to 42 d) diets, based on wheat and soy-bean meal, were available ad libitum...
April 18, 2017: Poultry Science
https://www.readbyqxmd.com/read/28425075/technical-note-real-time-web-based-wireless-visual-guidance-system-for-radiotherapy
#19
Danny Lee, Siyong Kim, Jatinder R Palta, Taeho Kim
Describe a Web-based wireless visual guidance system that mitigates issues associated with hard-wired audio-visual aided patient interactive motion management systems that are cumbersome to use in routine clinical practice. Web-based wireless visual display duplicates an existing visual display of a respiratory-motion management system for visual guidance. The visual display of the existing system is sent to legacy Web clients over a private wireless network, thereby allowing a wireless setting for real-time visual guidance...
April 19, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28421358/vitamin-d-supplementation-for-the-management-of-knee-osteoarthritis-a-systematic-review-of-randomized-controlled-trials
#20
Salman Hussain, Ambrish Singh, Mohd Akhtar, Abul Kalam Najmi
Conflicting evidence exists concerning the supplementation of vitamin D in knee osteoarthritis condition. This systematic literature review was done to explore the effects of vitamin D supplementation in the management of knee osteoarthritis. Electronic literature search was done in databases like PubMed(®), Embase(®), and Cochrane CENTRAL from inception to 6th July 2016. The quality of included Randomized Controlled Trials (RCTs) was assessed using Cochrane risk of bias tool. We considered change in Western Ontario and McMaster Universities (WOMAC) index, Visual Analog Scale (VAS) and Functional Pain Score (FPS) as the primary outcome measure...
April 18, 2017: Rheumatology International
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