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Carey D Balaban, Joseph M Furman
This study provides the first clear evidence that the generation of optokinetic nystagmus fast phases is a decision process that is influenced by performance of a concurrent disjunctive reaction time task (DRT). Ten subjects performed an auditory DRT during constant velocity optokinetic stimulation. Eye movements were measured in three dimensions with a magnetic search coil. Slow phase (SP) durations were defined as the interval between fast phases (FPs). There were three main findings. Firstly, human optokinetic nystagmus SP durations are consistent with a model of a Gaussian basic interval generator (a type of biological clock), such that FPs can be triggered randomly at the end of a clock cycle (mean duration: 200-250 ms); Kolmogorov-Smirnov tests could not reject the modeled cumulative distribution for any data trials...
October 19, 2016: Journal of Neurophysiology
Maciek Godycki-Cwirko, Marek Nocun, Christopher C Butler, Paul Little, Theo Verheij, Kerenza Hood, Nils Fleten, Anna Kowalczyk, Hasse Melbye
BACKGROUND: Acute cough and lower respiratory tract infections (LRTIs) are one of the most important causes of lost working hours. AIM: to explore variation and predictors in family practitioners (FPs) advice to patients with LRTIs about taking time off work in different European countries. METHODS: Prospective observational study in primary care networks in 12 countries, with multilevel mixed-effects binomial logistic regression. RESULTS: 324 FPs recruited 1616 employed adults who presented to primary care with LRTIs...
2016: PloS One
Kun Wang, Wenjun Zhu, Shifang Xiao, Jun Chen, Wangyu Hu
Large scale atomistic simulations with suitable interatomic potentials are widely employed by scientists or engineers of different areas. The quick generation of high-quality interatomic potentials is urgently needed. This largely relies on the developments of potential construction methods and algorithms in this area. Quantities of interatomic potential models have been proposed and parameterized with various methods, such as the analytic method, the force-matching approach and multi-object optimization method, in order to make the potentials more transferable...
October 19, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Martin Kuete, HongFang Yuan, Aude Laure Tchoua Kemayou, Emmanuel Ancel Songo, Fan Yang, XiuLan Ma, ChengLiang Xiong, HuiPing Zhang
BACKGROUND: Integration of family planning services (FPS) into human immunodeficiency virus (HIV) care for HIV-infected women is an important aspect of the global prevention of mother-to-child transmission (PMTCT) strategy. We assessed the integration of FPS into routine care of HIV-infected mothers by evaluating the uptake and barriers of contraception and PMTCT services. METHODS: We conducted an interventional study using the interrupted time series approach in the health care facilities located in Yaounde, Cameroon...
2016: Patient Preference and Adherence
Jinxin Li, Shujie Liu, Juan Wang, Jing Li, Dahui Liu, Jianli Li, Wenyuan Gao
In this work, we selected three fungi strains (Aspergillus niger, Aspergillus flavus and Aspergillus oryzae) as elicitors prepared from mycelium or fermentation broth to improve ginsenosides production in adventitious roots culture. The results showed that ginsenosides production (29.90±4.67mgg(-1)) was significantly enhanced upon elicitation with 200mgL(-1)A. niger elicitor prepared from mycelium, which was 3.52-fold of untreated group. HPLC-ESI-MS(n) analysis was performed, showing that ginsenoside Rb3 was present after treatment with the A...
October 13, 2016: Journal of Biotechnology
Mahsa Akhbari, Mohammad B Shamsollahi, Omid Sayadi, Antonis A Armoundas, Christian Jutten
In this paper, we propose a novel method for extracting fiducial points (FPs) of electrocardiogram (ECG) signals. We propose the use of multi hidden Markov model (MultiHMM) as opposed to the traditional use of Classic HMM. In the MultiHMM method, each segment of an ECG beat is represented by a separate ergodic continuous density HMM. Each HMM has different state number and is trained separately. In the test step, the log-likelihood of two consecutive HMMs is compared and a path is estimated, which shows the correspondence of each part of the ECG signal to the HMM with the maximum log-likelihood...
September 28, 2016: Computers in Biology and Medicine
Julie Easley, Baukje Miedema, June C Carroll, Donna P Manca, Mary Ann O'Brien, Fiona Webster, Eva Grunfeld
OBJECTIVE: To explore health care provider (HCP) perspectives on the coordination of cancer care between FPs and cancer specialists. DESIGN: Qualitative study using semistructured telephone interviews. SETTING: Canada. PARTICIPANTS: A total of 58 HCPs, comprising 21 FPs, 15 surgeons, 12 medical oncologists, 6 radiation oncologists, and 4 GPs in oncology. METHODS: This qualitative study is nested within a larger mixed-methods program of research, CanIMPACT (Canadian Team to Improve Community-Based Cancer Care along the Continuum), focused on improving the coordination of cancer care between FPs and cancer specialists...
October 2016: Canadian Family Physician Médecin de Famille Canadien
Andriana Barisic, Maxine Kish, Julie Gilbert, Nicole Mittmann, Rahim Moineddin, Jeffrey Sisler, Peter Vedsted, Eva Grunfeld
OBJECTIVE: To examine provincial and regional differences in FPs' direct access to cancer diagnostic investigations and advice from other specialists regarding investigations and referrals, and to explore FPs' perceptions about wait times for diagnostic investigations and receipt of results. DESIGN: A cross-sectional, online survey. SETTING: British Columbia, Manitoba, and Ontario. PARTICIPANTS: A sample of FPs from participating provinces...
October 2016: Canadian Family Physician Médecin de Famille Canadien
Jeffrey Sisler, Genevieve Chaput, Jonathan Sussman, Emmanuel Ozokwelu
OBJECTIVE: To offer FPs a summary of evidence-based recommendations to guide their follow-up survivorship care of women treated for breast cancer. QUALITY OF EVIDENCE: A literature search was conducted in MEDLINE from 2000 to 2016 using the search words breast cancer, survivorship, follow-up care, aftercare, guidelines, and survivorship care plans, with a focus on review of recent guidelines published by national cancer organizations. Evidence ranges from level I to level III...
October 2016: Canadian Family Physician Médecin de Famille Canadien
Yuwei Jiang, Sonja E DiGregorio, Martin L Duennwald, Patrick Lajoie
The palette of fluorescent proteins (FPs) available for live-cell imaging contains proteins that strongly differ in their biophysical properties. FPs cannot be assumed to be equivalent and in certain cases could significantly perturb the behavior of fluorescent reporters. We employed Saccharomyces cerevisiae to comprehensively study the impact of FPs on the toxicity of polyglutamine (polyQ) expansion proteins associated with Huntington's disease. The toxicity of polyQ fusion constructs is highly dependent on the sequences flanking the polyQ repeats...
October 13, 2016: Traffic
Hai V Nguyen, Gavin Siew Wei Tan, Robyn Jennifer Tapp, Shweta Mital, Daniel Shu Wei Ting, Hon Tym Wong, Colin S Tan, Augustinus Laude, E Shyong Tai, Ngiap Chuan Tan, Eric A Finkelstein, Tien Yin Wong, Ecosse L Lamoureux
PURPOSE: To determine the incremental cost-effectiveness of a new telemedicine technician-based assessment relative to an existing model of family physician (FP)-based assessment of diabetic retinopathy (DR) in Singapore from the health system and societal perspectives. DESIGN: Model-based, cost-effectiveness analysis of the Singapore Integrated Diabetic Retinopathy Program (SiDRP). PARTICIPANTS: A hypothetical cohort of patients aged 55 years with type 2 diabetes previously not screened for DR...
October 7, 2016: Ophthalmology
Karin Nienhaus, Gerd Ulrich Nienhaus
Photoactivatable fluorescent proteins (FPs) have become essential markers for nanoscopy on live specimens. In this issue of ACS Nano, Wang et al. present a reversibly photoswitching FP, GMars-Q, which they promote as an advanced marker for RESOLFT imaging because of its low residual intensity in the off state and low switching fatigue. Here, we explain the observed peculiar photobleaching behavior of GMars-Q by a mechanism that involves efficient shelving of proteins in dark states, resulting in low switching fatigue and low residual off intensity...
October 10, 2016: ACS Nano
Philipp Attanasio, Melika Mirdamadi, Jean-Yves Wielandts, Burkert Pieske, Florian Blaschke, Leif-Hendrik Boldt, Pierre Jais, Wilhelm Haverkamp, Martin Huemer
AIMS: For cardiac implantable electronic device (CIED) implantations, visualization of lead placement is necessary and fluoroscopy remains by far the most commonly used technique. With simple changes in the X-ray system settings, total radiation dose can be reduced significantly. The purpose of this study was to assess the safety and efficacy of various CIED implantations performed after implementation of a new dose reduction protocol (DRP). METHODS AND RESULTS: We conducted a retrospective chart review of 584 patients undergoing CIED implantation or revision in our hospital...
October 4, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Nicolas Leduc, Vincent Atallah, Patrick Escarmant, Vincent Vinh-Hung
Monitoring and controlling respiratory motion is a challenge for the accuracy and safety of therapeutic irradiation of thoracic tumors. Various commercial systems based on the monitoring of internal or external surrogates have been developed but remain costly. In this article we describe and validate Madibreast, an in-house-made respiratory monitoring and processing device based on optical tracking of external markers. We designed an optical apparatus to ensure real-time submillimetric image resolution at 4 m...
2016: Journal of Applied Clinical Medical Physics
Diana Di Paolo, Oshri Afanzar, Judith P Armitage, Richard M Berry
For the past two decades, the use of genetically fused fluorescent proteins (FPs) has greatly contributed to the study of chemotactic signalling in Escherichia coli including the activation of the response regulator protein CheY and its interaction with the flagellar motor. However, this approach suffers from a number of limitations, both biological and biophysical: for example, not all fusions are fully functional when fused to a bulky FP, which can have a similar molecular weight to its fused counterpart; they may interfere with the native interactions of the protein and the chromophores of FPs have low brightness and photostability and fast photobleaching rates...
November 5, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
T Kwak, K Drews-Elger, A Ergonul, P C Miller, A Braley, G H Hwang, D Zhao, A Besser, Y Yamamoto, H Yamamoto, D El-Ashry, J M Slingerland, M E Lippman, B I Hudson
The receptor for advanced glycation end products (RAGE) is highly expressed in various cancers and is correlated with poorer outcome in breast and other cancers. Here we tested the role of targeting RAGE by multiple approaches in the tumor and tumor microenvironment, to inhibit the metastatic process. We first tested how RAGE impacts tumor cell-intrinsic mechanisms using either RAGE overexpression or knockdown with short hairpin RNAs (shRNAs). RAGE ectopic overexpression in breast cancer cells increased MEK-EMT (MEK-epithelial-to-mesenchymal transition) signaling, transwell invasion and soft agar colony formation, and in vivo promoted lung metastasis independent of tumor growth...
September 26, 2016: Oncogene
Y T Ren, F Cui, F Yang, Z H Chen, L Ling, X S Huang
Objective: To analyze the features of needle electromyography (EMG) in patients with amyotrophic lateral sclerosis (ALS), and explore the correlation between EMG parameters of the tenth thoracic paraspinal muscle and disease duration, rate of disease progression, forced vital capacity (FVC) and revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R). Methods: Standard EMG was recorded from unilateral sternocleidomastoid muscle and/or tongue muscles, upper and lower limbs muscles and the tenth thoracic paraspinal muscle in 112 patients with definite ALS between March 2012 and June 2013 in the Department of Neurology at Chinese PLA General Hospital...
September 6, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Hirokazu Miyoshi, Mitsunori Hiroura, Kazunori Tsujimoto, Namiko Irikura, Tamaki Otani, Yasuo Shinohara
A new scintillation imaging material [scintillator-silica fine powder (FP)] was prepared using silica FPs and scintillator-encapsulating silica nanoparticles (NPs) (scintillator-silica NPs). The wt% values of scintillator-silica NPs on the scintillator-silica FPs were 38, 43, 36 and 44%. Scintillation images of (3)H, (63)Ni, (35)S, (33)P, (204)Tl, (89)Sr and (32)P dropped on the scintillator-silica FPs were obtained at about 37 kBq per 0.1-10 µl with a charge-coupled device (CCD) imager for a 5 min exposure...
September 24, 2016: Radiation Protection Dosimetry
Zhichao Dong, Haobo Cheng
A hybrid algorithm is proposed in this study for demodulating a single spatial carrier fringe pattern (FP) of interferometric measurement, which essentially combines the spatial carrier phase shift (SCPS) method and Fourier transform (FT) method. It firstly extracts three phase-shifted FPs from a single spatial carrier FP, then employs the FT method and a subtraction operation to determine the phase shift of three phase-shifted FPs, and finally retrieves the phase map using a least-square phase shift algorithm...
September 20, 2016: Applied Optics
Shona Nicole Dutton, Sarah May Dennis, Nicholas Zwar, Mark Fort Harris
BACKGROUND: There are a substantial number of instruments for primary-care clinicians to assess physical-activity (PA). However, there are few studies that have explored the views of clinicians regarding comparative acceptability and ease of use. A better understanding of how clinicians perceive instruments could help overcome barriers, and inform future interventions. This study explored the acceptability of five PA-assessment instruments amongst a sample of Australian primary-care clinicians, including family-physicians (FP) and practice-nurses (PN)...
2016: BMC Family Practice
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