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propionibacterium

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https://www.readbyqxmd.com/read/28734717/preoperative-doxycycline-does-not-decolonize-propionibacterium-acnes-from-the-skin-of-the-shoulder-a-randomized-controlled-trial
#1
Surena Namdari, Thema Nicholson, Javad Parvizi, Matthew Ramsey
BACKGROUND: Propionibacterium acnes is frequently cultured in patients undergoing both primary and revision shoulder surgery. The purpose of this study was to evaluate the efficacy and safety of preoperative oral administration of doxycycline in decreasing the colonization of skin around the shoulder by P. acnes. METHODS: This was a single-institution, prospective, randomized controlled trial of male patients undergoing shoulder arthroscopy. Patients were randomized to receive oral doxycycline (100 mg twice a day) for 7 days or to the standard of care (no drug)...
July 19, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28732695/optimization-of-genotypic-and-biochemical-methods-to-profile-p-acnes-isolates-from-a-patient-population
#2
Rubén Cebrián, Sergio Arévalo, Salvador Arias-Santiago, Cristina Riazzo, M Dolores Rojo, Pilar Bermúdez, Eva Valdivia, Manuel Martínez-Bueno, Mercedes Maqueda
Propionibacterium acnes is a key factor in the pathogenesis of acne vulgaris, although currently it is also being associated with medical-device infections. The aim of this work was to validate a safe and quick identification and typing of 24 clinical isolates of Propionibacterium acnes, applying a range of biochemical as well as genetic methods, and investigating the pathogenic potential to associate the different types with human health. RAPD-PCRs revealed the existence of two discernible clusters in correspondence with the phylogroups I and II, according to the PAtig gene polymorphism, leading them to be assigned as P...
July 18, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28716098/awakening-sleeping-beauty-production-of-propionic-acid-in-escherichia-coli-through-the-sbm-operon-requires-the-activity-of-a-methylmalonyl-coa-epimerase
#3
Ricardo Axayacatl Gonzalez-Garcia, Tim McCubbin, Annalena Wille, Manuel Plan, Lars Keld Nielsen, Esteban Marcellin
BACKGROUND: Propionic acid is used primarily as a food preservative with smaller applications as a chemical building block for the production of many products including fabrics, cosmetics, drugs, and plastics. Biological production using propionibacteria would be competitive against chemical production through hydrocarboxylation of ethylene if native producers could be engineered to reach near-theoretical yield and good productivity. Unfortunately, engineering propionibacteria has proven very challenging...
July 17, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28714181/involvement-of-adenosine-triphosphate-binding-cassette-subfamily-b-member-1-in-the-augmentation-of-triacylglycerol-excretion-by-propionibacterium-acnes-in-differentiated-hamster-sebocytes
#4
Koji Mizuno, Noriko Akimoto, Mina Kawamura, Keisuke Nakase, Norihisa Noguchi, Takashi Sato
An onset of acne, a common inflammatory skin disease, is associated with excess sebum production and secretion in sebaceous glands. Because Propionibacterium acnes has been reported to augment intracellular sebum accumulation in sebaceous glands in hamsters, it remains unclear whether P. acnes influences sebum secretion from differentiated sebocytes. Both P. acnes culture media (Acnes73-CM) and formalin-killed P. acnes (F-Acnes73) dose-dependently increased the extracellular levels of triacylglycerol (TG), a major sebum component, and Rhodamine 123, a substrate of adenosine triphosphate-binding cassette (ABC) transporter, from differentiated hamster sebocytes (DHS)...
July 17, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28712017/the-distribution-of-infection-with-propionibacterium-acnes-is-equal-in-patients-with-cervical-and-lumbar-disc-herniation
#5
Naghmeh Javanshir, Firooz Salehpour, Javad Aghazadeh, Farhad Mirzaei, Seyed Ahmad Naseri Alavi
BACKGROUND: Cervical and back pains are important clinical problems affecting human populations globally. It is suggested that Propionibacterium acnes (P. acnes) is associated with disc herniation. The aim of this study is to evaluate the distribution of P. acnes infection in the cervical and lumbar disc material obtained from patients with disc herniation. METHODS AND MATERIAL: A total of 145 patients with mean age of 45.21 ± 11.24 years who underwent micro-discectomy in cervical and lumbar regions were enrolled into the study...
July 15, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28701012/-diagnosis-of-periprosthetic-joint-infection-of-shoulder-arthroplasties
#6
Bernd Fink, Florian Sevelda
Periprosthetic joint infection of shoulder arthroplasties is one of the most frequent reasons for pain and revision surgery of shoulder arthroplasties. Propionibacterium acnes is one of the commonest microorganisms causing periprosthetic joint infection in shoulder arthroplasties. It is difficult to detect this slow growing microorganism. This paper gives an overview of the different diagnostic methods. A combination of unspecific and specific tests (detection of microorganism and sensitivity to antibiotics) is helpful in identifying a periprosthetic shoulder infection...
July 12, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28697465/combined-photodynamic-and-antibiotic-therapy-for-skin-disorder-via-lipase-sensitive-liposomes-with-enhanced-antimicrobial-performance
#7
Songhee Jeong, Jonghwan Lee, Byeong Nam Im, Hyung Park, Kun Na
A lipase-sensitive singlet oxygen-producible and erythromycin-loaded liposome (LSSPL) was developed for combination antibacterial therapy for skin disorder. The LSSPL was synthesized by coating pullulan-pheophorbide a (PU-Pheo A) conjugates onto erythromycin-loaded liposomes composed of 1,2-dipalmitoyl-sn-phosphatidylcholine (DPPC) and cholesterol. Lipase activity was chosen as the environmental-stimulus for the controlled release of erythromycin and Pheo A from LSSPL because skin inflammation-inducing Propionibacterium acnes (P...
July 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/28694086/an-outbreak-of-post-craniotomy-propionibacterium-acnes-infections-at-a-tertiary-hospital-england-2011-a-case-control-study-identifies-dural-implants-as-a-risk-factor-for-infection
#8
Caoimhe McKerr, Nic Coetzee, Obaghe Edeghere, Shakeel Suleman, Neville Q Verlander, Krishna Banavathi
BACKGROUND: In 2011, 15 deep-seated Propionibacterium acnes infections were identified in patients following craniotomies in a hospital in the UK. AIM: To describe the outbreak and report findings from the investigation undertaken in order to identify the source & risk factors and inform control measures. METHODS: Data were obtained from hospital clinical records and included patient and surgical variables. Cases were defined as patients with microbiologically confirmed deep or organ space surgical site infection (SSI) caused by P...
July 7, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28690602/geography-ethnicity-or-subsistence-specific-variations-in-human-microbiome-composition-and-diversity
#9
REVIEW
Vinod K Gupta, Sandip Paul, Chitra Dutta
One of the fundamental issues in the microbiome research is characterization of the healthy human microbiota. Recent studies have elucidated substantial divergences in the microbiome structure between healthy individuals from different race and ethnicity. This review provides a comprehensive account of such geography, ethnicity or life-style-specific variations in healthy microbiome at five major body habitats-Gut, Oral-cavity, Respiratory Tract, Skin, and Urogenital Tract (UGT). The review focuses on the general trend in the human microbiome evolution-a gradual transition in the gross compositional structure along with a continual decrease in diversity of the microbiome, especially of the gut microbiome, as the human populations passed through three stages of subsistence like foraging, rural farming and industrialized urban western life...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28690466/propionibacterium-acnes-host-inflammatory-response-during-periprosthetic-infection-is-joint-specific
#10
Scott R Nodzo, K Keely Boyle, Samrath Bhimani, Thomas R Duquin, Andy O Miller, Geoffrey H Westrich
BACKGROUND: Propionibacterium acnes (P. acnes) has become increasingly recognized as a cause of periprosthetic joint infection (PJI). QUESTIONS/PURPOSES: It is not currently known if the clinical presentation of P. acnes varies depending on the joint being infected. METHODS: We retrospectively reviewed patients infected with P. acnes after total hip, knee, and shoulder arthroplasty from two institutions. Patients were classified as having a PJI based on the Musculoskeletal Infection Society criteria and were excluded if they had a polymicrobial culture...
July 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28686683/immunohistochemical-identification-of-propionibacterium-acnes-in-granuloma-and-inflammatory-cells-of-myocardial-tissues-obtained-from-cardiac-sarcoidosis-patients
#11
Naoya Asakawa, Keisuke Uchida, Mamoru Sakakibara, Kazunori Omote, Keiji Noguchi, Yusuke Tokuda, Kiwamu Kamiya, Kanako C Hatanaka, Yoshihiro Matsuno, Shiro Yamada, Kyoko Asakawa, Yuichiro Fukasawa, Toshiyuki Nagai, Toshihisa Anzai, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Masanori Hirota, Makoto Orii, Takashi Akasaka, Kenta Uto, Yasushige Shingu, Yoshiro Matsui, Shin-Ichiro Morimoto, Hiroyuki Tsutsui, Yoshinobu Eishi
BACKGROUND: Although rare, cardiac sarcoidosis (CS) is potentially fatal. Early diagnosis and intervention are essential, but histopathologic diagnosis is limited. We aimed to detect Propionibacterium acnes, a commonly implicated etiologic agent of sarcoidosis, in myocardial tissues obtained from CS patients. METHODS AND RESULTS: We examined formalin-fixed paraffin-embedded myocardial tissues obtained by surgery or autopsy and endomyocardial biopsy from patients with CS (n = 26; CS-group), myocarditis (n = 15; M-group), or other cardiomyopathies (n = 39; CM-group) using immunohistochemistry (IHC) with a P...
2017: PloS One
https://www.readbyqxmd.com/read/28680616/a-case-of-bilateral-hilar-and-mediastinal-lymphadenopathy-developing-during-treatment-for-mycobacterium-avium-complex
#12
Yumie Yamanaka, Akimasa Sekine, Hideaki Yamakawa, Tomohisa Baba, Koji Okudela, Tamiko Takemura, Takashi Ogura
We report a rare case of an immunocompetent patient with Mycobacterium avium complex (MAC) disease in which bilateral hilar lymphadenopathy developed during anti-MAC treatment. This case indicates that Propionibacterium acnes would be present and might be a cause of sarcoidosis even in patients with MAC.
July 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28678647/combination-of-benzoyl-peroxide-5-gel-with-liquid-cleanser-and-moisturizer-spf-30-in-acne-treatment-results-in-high-levels-of-subject-satisfaction-good-adherence-and-favorable-tolerability
#13
Mi-Ran Kim, Nabil Kerrouche
BACKGROUND: Skin care products (cleansers and moisturizers) to complement benzoyl peroxide (BPO) in the treatment of acne may improve treatment tolerability and adherence. OBJECTIVE: Evaluate subject satisfaction after use of BPO 5% gel in combination with liquid cleanser and moisturizer SPF 30. METHODS: Open-label study including subjects aged ≥12 years with mild-to-moderate facial acne; ClinicalTrials.gov Identifier: NCT02589405. Once daily BPO 5% gel, twice daily liquid cleanser and once daily moisturizer SPF 30 were applied for 12 weeks...
July 5, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28677199/acne
#14
Klaus Degitz, Falk Ochsendorf
Acne is a chronic disease with a high prevalence among adolescents. Key pathogenetic factors (and their clinical correlates) are increased sebum production (seborrhea), follicular hyperkeratosis (comedones), and perifollicular inflammation (papules and pustules). The disease is modulated by a variety of endogenous (androgens, IGF-1, neuroendocrine factors) and exogenous (Propionibacterium acnes, diet, friction, ingredients of medical or cosmetic topical products) triggers. Acne is associated with high morbidity, and even mild manifestations may potentially cause considerable impairment in quality of life...
July 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28677193/akne
#15
Klaus Degitz, Falk Ochsendorf
Akne ist eine chronische Erkrankung mit hoher Prävalenz unter Jugendlichen. Pathogenetische Hauptfaktoren (und ihre klinischen Korrelate) sind gesteigerte Talgproduktion (Seborrhoe), follikuläre Hyperkeratose (Komedonen) und perifollikuläre Entzündungsvorgänge (Papulopusteln). Die Krankheit wird von endogenen (Androgene, IGF-1, neuroendokrine Faktoren) und exogenen (Propionibacterium acnes, Diät, mechanische Irritation, Inhaltsstoffe medizinischer oder kosmetischer Externa) Einflüssen moduliert. Akne geht mit zum Teil hoher Morbidität einher und kann bereits bei leichter Ausprägung eine erhebliche Verschlechterung der Lebensqualität bewirken...
July 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28666043/difficult-to-detect-low-grade-infections-responsible-for-poor-outcomes-in-total-knee-arthroplasty
#16
Luis Grau, Meredith Alane Gunder, Michaela Schneiderbauer
In this article, we present the case of a patient with a stiff, painful knee after total knee arthroplasty, and with erythrocyte sedimentation rate, C-reactive protein level, and synovial fluid analysis within normal limits. Open biopsy for cultures showed Propionibacterium acnes prosthetic joint infection, which was successfully treated with 2-stage revision and intravenous antibiotics.
May 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28659905/long-term-survey-is-necessary-to-reveal-various-shifts-of-microbial-composition-in-corals
#17
Shan-Hua Yang, Ching-Hung Tseng, Chang-Rung Huang, Chung-Pin Chen, Kshitij Tandon, Sonny T M Lee, Pei-Wen Chiang, Jia-Ho Shiu, Chaolun A Chen, Sen-Lin Tang
The coral holobiont is the assemblage of coral host and its microbial symbionts, which functions as a unit and is responsive to host species and environmental factors. Although monitoring surveys have been done to determine bacteria associated with coral, none have persisted for >1 year. Therefore, potential variations in minor or dominant community members that occur over extended intervals have not been characterized. In this study, 16S rRNA gene amplicon pyrosequencing was used to investigate the relationship between bacterial communities in healthy Stylophora pistillata in tropical and subtropical Taiwan over 2 years, apparently one of the longest surveys of coral-associated microbes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28654220/temperature-drives-the-assembly-of-endophytic-communities-seasonal-succession
#18
Andrea Campisano, Davide Albanese, Sohail Yousaf, Michael Pancher, Claudio Donati, Ilaria Pertot
Endophytic microorganisms asymptomatically colonise plant tissues. Exploring the assembly dynamics of bacterial endophytic communities is essential to understand the functioning of the plant holobiont and to optimise their possible use as biopesticides or plant biostimulants. We studied the variation in endophytic communities in above and below-ground organs in Vitis vinifera in the field. To understand the specific effect of temperature on endophytic communities, a separate experiment was set up where grapevine cuttings were grown under controlled conditions at three different temperatures...
June 27, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28647025/olumacostat-glasaretil-a-promising-topical-sebum-suppressing-agent-that-affects-all-major-pathogenic-factors-of-acne-vulgaris
#19
Bodo C Melnik
Hunt et al. show that olumacostat glasaretil, an inhibitor of acetyl coenzyme A carboxylase, reduces saturated and monounsaturated fatty acyl chains in sebaceous lipids. Topical olumacostat glasaretil application decreases hamster ear sebaceous gland size and shows efficacy in treating patients with acne vulgaris. Olumacostat glasaretil-mediated sebum suppression may reduce Propionibacterium acnes growth and biofilm formation, comedogenesis, and inflammation.
July 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28646583/sebum-lipids-influence-macrophage-polarization-and-activation
#20
M Lovászi, M Mattii, K Eyerich, Attila Gácsi, Erzsébet Csányi, D Kovács, R Rühl, A Szegedi, L Kemény, M Ståhle, C C Zouboulis, S Eyerich, D Törőcsik
BACKGROUND: As lipids are known to regulate macrophage functions it is reasonable to suppose that a sebocyte - macrophage axis mediated by sebum lipids may exist. OBJECTIVE: To investigate if sebocytes could contribute to the differentiation, polarization and function of macrophages with their secreted lipids. METHODS: Oil-red-O lipid staining and Raman spectroscopy were used to assess the dermal lipid content and penetration. Immunohistochemistry was used to analyse the macrophage subsets...
June 24, 2017: British Journal of Dermatology
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