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https://www.readbyqxmd.com/read/28207943/the-role-of-the-skin-microbiome-in-atopic-dermatitis-a-systematic-review
#1
REVIEW
R Dybboe, J Bandier, L Skov, L Engstrand, J D Johansen
BACKGROUND: Dysbiosis is a hallmark of atopic dermatitis. The composition of skin microbiome communities and the causality of dysbiosis in eczema have not been well established. OBJECTIVE: To describe the skin microbiome profile in atopic dermatitis and address if there is a causal relationship between dysbiosis and atopic dermatitis. METHODS: The protocol is registered in PROSPERO (CRD42016035813). We searched PubMed, Embase, Scopus and ClinicalTrials...
February 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28194314/evolutionary-and-functional-implications-of-hypervariable-loci-within-the-skin-virome
#2
Geoffrey D Hannigan, Qi Zheng, Jacquelyn S Meisel, Samuel S Minot, Frederick D Bushman, Elizabeth A Grice
Localized genomic variability is crucial for the ongoing conflicts between infectious microbes and their hosts. An understanding of evolutionary and adaptive patterns associated with genomic variability will help guide development of vaccines and antimicrobial agents. While most analyses of the human microbiome have focused on taxonomic classification and gene annotation, we investigated genomic variation of skin-associated viral communities. We evaluated patterns of viral genomic variation across 16 healthy human volunteers...
2017: PeerJ
https://www.readbyqxmd.com/read/28180934/measuring-acne-using-coproporphyrin-iii-protoporphyrin-ix-and-lesion-specific-inflammation-an-exploratory-study
#3
Sachin V Patwardhan, C Richter, A Vogt, U Blume-Peytavi, D Canfield, J Kottner
Propionibacterium acnes: (P. acnes) produce Porphyrins; however, fluorescence measurement of Porphyrins from Ultraviolet-A (UVA) images has failed to establish a correlation. Acne clinical research and imaging has ignored the spectral excitation-emission characteristics and the exact pattern of the Porphyrins synthesized by P. acnes. In this exploratory study, for the first time, the possible relationships of Coproporphyrin III (CpIII) and Protoporphyrin IX (PpIX) fluorescence as well as acne lesion-specific inflammation measurements with clinical signs of acne are investigated...
February 8, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28175925/skin-microbiome-in-small-and-large-plaque-parapsoriasis
#4
Alexander Salava, Pedro Pereira, Velma Aho, Liisa Väkevä, Lars Paulin, Petri Auvinen, Annamari Ranki, Antti Lauerma
Staphylococcal enterotoxins have been shown to promote lymphoma-associated immune dysregulation. This study examined changes in the skin microbiome of parapsoriasis compared with intact skin. Swab microbiome specimens were taken of the parapsoriasis lesions of 13 patients. Control samples were taken from contralateral healthy sides of the body. Microbiotas were characterized by sequencing the V1-V3 region of the 16S ribosomal RNA bacterial genes on the Illumina MiSeq platform. The most common genera in the microbiome data were Propionibacterium (27...
February 8, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28168343/is-infection-the-possible-initiator-of-disc-disease-an-insight-from-proteomic-analysis
#5
S Rajasekaran, Chitraa Tangavel, Siddharth N Aiyer, Sharon Miracle Nayagam, M Raveendran, Naveen Luke Demonte, Pramela Subbaiah, Rishi Kanna, Ajoy Prasad Shetty, K Dharmalingam
STUDY DESIGN: Proteomic and 16S rDNA analysis of disc tissues obtained in vivo. OBJECTIVE: To address the controversy of infection as an aetiology for disc disorders through protein profiling. There is raging controversy over the presence of bacteria in human lumbar discs in vivo, and if they represent contamination or infection. Proteomics can provide valuable insight by identifying proteins signifying bacterial presence and, also host defence response proteins (HDRPs), which will confirm infection...
February 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28161414/dairy-propionibacteria-prevent-the-proliferative-effect-of-plant-lectins-on-sw480%C3%A2-cells-and-protect-the-metabolic-activity-of-the-intestinal-microbiota-in%C3%A2-vitro
#6
Gabriela Zárate, Gabriel D Sáez, Adriana Pérez Chaia
Plant lectins are specific carbohydrate-binding proteins that are widespread in legumes such as beans and pulses, seeds, cereals, and many plants used as farm feeds. They are highly resistant to cooking and digestion, reaching the intestinal lumen and/or blood circulation with biological activity. Since many legume lectins trigger harmful local and systemic reactions after their binding to the mucosal surface, these molecules are generally considered anti-nutritive and/or toxic substances. In the gut, specific cell receptors and bacteria may interact with these dietary components, leading to changes in intestinal physiology...
February 1, 2017: Anaerobe
https://www.readbyqxmd.com/read/28161181/effects-of-bacterial-direct-fed-microbials-on-ruminal-characteristics-methane-emission-and-milk-fatty-acid-composition-in-cows-fed-high-or-low-starch-diets
#7
C Philippeau, A Lettat, C Martin, M Silberberg, D P Morgavi, A Ferlay, C Berger, P Nozière
This study investigated the effects of bacterial direct-fed microbials (DFM) on ruminal fermentation and microbial characteristics, methane (CH4) emission, diet digestibility, and milk fatty acid (FA) composition in dairy cows fed diets formulated to induce different ruminal volatile fatty acid (VFA) profiles. Eight ruminally cannulated dairy cows were divided into 2 groups based on parity, days in milk, milk production, and body weight. Cows in each group were fed either a high-starch (38%, HS) or a low-starch (2%, LS) diet in a 55:45 forage-to-concentrate ratio on a dry matter (DM) basis...
February 1, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28161135/temporomandibular-total-joint-prosthesis-infections-a-ten-year-retrospective-analysis
#8
W S McKenzie, P J Louis
A retrospective review of 178 total temporomandibular joint replacements (TJR) performed on 106 patients at the University of Alabama at Birmingham during the years 2000-2010 was completed. Data regarding sex, past medical history, prosthesis manufacturer, microbiology, antibiotic therapy, and the need for additional procedures were obtained from the medical records of patients who developed a prosthetic joint infection following TJR. Of the 106 patients, 95 (89.6%) were female and 11 (10.4%) were male. The average age of the patients was 47 years (range 19-68 years)...
February 1, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28150367/open-label-randomized-multicenter-phase-iii-study-to-evaluate-the-safety-and-efficacy-of-benzoyl-peroxide-gel-in-long-term-use-in-patients-with-acne-vulgaris-a-secondary-publication
#9
Makoto Kawashima, Toshitaka Nagare, Tsuneo Katsuramaki
An open-label, randomized, multicenter study was conducted to evaluate the safety and efficacy of long-term use of 2.5% and 5% benzoyl peroxide (BPO) gels administrated once daily for 52 weeks to Japanese patients with acne vulgaris. The efficacy of the study drugs was evaluated by counting inflammatory lesions and non-inflammatory lesions. Safety was evaluated based on adverse events, local skin tolerability scores and laboratory test values. In total, 458 subjects were included in the efficacy and safety analyses...
February 2, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28150107/acne-and-rosacea
#10
REVIEW
Mauro Picardo, Lawrence F Eichenfield, Jerry Tan
Acne, one of the most common skin diseases, affects approximately 85% of the adolescent population, and occurs most prominently at skin sites with a high density of sebaceous glands such as the face, back, and chest. Although often considered a disease of teenagers, acne is occurring at an increasingly early age. Rosacea is a chronic facial inflammatory dermatosis characterized by flushing (or transient facial erythema), persistent central facial erythema, inflammatory papules/pustules, and telangiectasia. Both acne and rosacea have a multifactorial pathology that is incompletely understood...
January 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28150076/current-advances-in-biological-production-of-propionic-acid
#11
REVIEW
Ismail Eş, Amin Mousavi Khaneghah, Seyed Mohammad Bagher Hashemi, Mohamed Koubaa
Propionic acid and its derivatives are considered "Generally Recognized As Safe" food additives and are generally used as an anti-microbial and anti-inflammatory agent, herbicide, and artificial flavor in diverse industrial applications. It is produced via biological pathways using Propionibacterium and some anaerobic bacteria. However, its commercial chemical synthesis from the petroleum-based feedstock is the conventional production process bit results in some environmental issues. Novel biological approaches using microorganisms and renewable biomass have attracted considerable recent attention due to economic advantages as well as great adaptation with the green technology...
February 1, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28143482/high-throughput-16srrna-gene-sequencing-reveals-the-correlation-between-propionibacterium-acnes-and-sarcoidosis
#12
Meng-Meng Zhao, Shan-Shan Du, Qiu-Hong Li, Tao Chen, Hui Qiu, Qin Wu, Shan-Shan Chen, Ying Zhou, Yuan Zhang, Yang Hu, Yi-Liang Su, Li Shen, Fen Zhang, Dong Weng, Hui-Ping Li
OBJECTIVE: This study aims to use high throughput 16SrRNA gene sequencing to examine the bacterial profile of lymph node biopsy samples of patients with sarcoidosis and to further verify the association between Propionibacterium acnes (P. acnes) and sarcoidosis. METHODS: A total of 36 mediastinal lymph node biopsy specimens were collected from 17 cases of sarcoidosis, 8 tuberculosis (TB group), and 11 non-infectious lung diseases (control group). The V4 region of the bacterial 16SrRNA gene in the specimens was amplified and sequenced using the high throughput sequencing platform MiSeq, and bacterial profile was established...
February 1, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28126936/draft-genome-sequence-of-an-erythromycin-resistant-propionibacterium-acnes-isolate-recovered-from-folliculitis-of-the-scalp
#13
Guillaume Ghislain Aubin, Stanimir Kambarev, Aurélie Guillouzouic, Amir Khammari, Brigitte Dréno, Stéphane Corvec
Propionibacterium acnes is now well-known and recognized for its implication in the pathogenesis of acne vulgaris. Here, we report the draft genome sequence of an erythromycin-resistant P. acnes strain isolated from a case of folliculitis of the scalp belonging to phylotype IA1 and sequence type 18 (ST18).
January 26, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28124400/a-multifactorial-comparison-of-ternary-combinations-of-essential-oils-in-topical-preparations-to-current-antibiotic-prescription-therapies-for-the-control-of-acne-vulgaris-associated-bacteria
#14
Lucy Owen, Martin Grootveld, Randolph Arroo, Victor Ruiz-Rodado, Penny Price, Katie Laird
Acne vulgaris, a chronic condition associated with overgrowth of Propionibacterium acnes and Staphylococcus epidermidis, is commonly treated with antibiotics. However, the emergence of antibiotic resistance has resulted in a need for alternative therapies. The aim of this study is to develop a topical preparation incorporating essential oils (EOs) for use against acne-associated bacteria and assess its efficacy against prescription therapies Dalacin T and Stiemycin. Antimicrobial screening of rosewood, clove bud and litsea EOs was conducted before interactions between binary and ternary combinations were determined against P...
January 26, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28119103/topical-delivery-of-roxithromycin-solid-state-forms-entrapped-in-vesicles
#15
Candice Csongradi, Jeanetta du Plessis, Marique Elizabeth Aucamp, Minja Gerber
Recently, considerable interest developed in using newer/improved antibiotics for the treatment of Acne vulgaris. During this study, different roxithromycin solid-state forms (i.e. crystalline and amorphous) were encapsulated into vesicle systems (niosomes, proniosomes, ufosomes and pro-ufosomes) for dermis targeted delivery. Characterization of the vesicles was done with transmission electron microscopy, light microscopy, droplet size, droplet size distribution, pH, zeta-potential and entrapment efficiency percentage...
January 21, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28117399/treatment-effects-of-lysozyme-shelled-microbubbles-and-ultrasound-in-inflammatory-skin-disease
#16
Ai-Ho Liao, Chi-Ray Hung, Chieh-Fu Lin, Yi-Chun Lin, Hang-Kang Chen
Acne vulgaris is the most common skin disorder, and is caused by Propionibacterium acnes (P. acnes) and can induce inflammation. Antibiotic therapy often needs to be administered for long durations in acne therapy, which results in extensive antibiotic exposure. The present study investigated a new treatment model for evaluating the antibacterial effects of lysozyme (LY)-shelled microbubbles (MBs) and ultrasound (US)-mediated LY-shelled MBs cavitation against P. acnes both in vitro and in vivo, with the aims of reducing the dose and treatment duration and improving the prognosis of acne vulgaris...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28111792/inhibition-of-propionibacterium-acnes-lipase-activity-by-the-antifungal-agent-ketoconazole
#17
Mizuki Unno, Otomi Cho, Takashi Sugita
The common skin disease acne vulgaris is caused by Propionibacterium acnes. A lipase secreted by this microorganism metabolizes sebum and the resulting metabolites evoke inflammation in human skin. The antifungal drug ketoconazole inhibits P. acnes lipase activity. We previously showed that the drug also inhibits the growth of P. acnes. Thus, ketoconazole may serve as an alternative treatment for acne vulgaris, which is important because the number of antibiotic-resistant P. acnes strains has been increasing...
January 23, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28109256/optimisation-of-methods-for-bacterial-skin-microbiome-investigation-primer-selection-and-comparison-of-the-454-versus-miseq-platform
#18
Madhura Castelino, Stephen Eyre, John Moat, Graeme Fox, Paul Martin, Pauline Ho, Mathew Upton, Anne Barton
BACKGROUND: The composition of the skin microbiome is predicted to play a role in the development of conditions such as atopic eczema and psoriasis. 16S rRNA gene sequencing allows the investigation of bacterial microbiota. A significant challenge in this field is development of cost effective high throughput methodologies for the robust interrogation of the skin microbiota, where biomass is low. Here we describe validation of methodologies for 16S rRNA (ribosomal ribonucleic acid) gene sequencing from the skin microbiome, using the Illumina MiSeq platform, the selection of primer to amplify regions for sequencing and we compare results with the current standard protocols...
January 21, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28099312/the-emperor-may-truly-have-new-clothes-commentary-on-an-article-by-zahab-s-ahsan-md-et-al-characterizing-the-propionibacterium-load-in-revision-shoulder-arthroplasty-a-study-of-137-culture-positive-cases
#19
https://www.readbyqxmd.com/read/28099305/characterizing-the-propionibacterium-load-in-revision-shoulder-arthroplasty-a-study-of-137-culture-positive-cases
#20
Zahab S Ahsan, Jeremy S Somerson, Frederick A Matsen
BACKGROUND: Propionibacterium is commonly recovered from explants or surrounding tissues in revision shoulder arthroplasty. Rather than attempting to differentiate a true infection from a false-positive result on the basis of the number of positive cultures, we characterized the amount of these bacteria in each specimen and shoulder. METHODS: The study included 137 revision shoulder arthroplasties from which a minimum of 4 specimens had been submitted for culture and at least 1 was positive for Propionibacterium...
January 18, 2017: Journal of Bone and Joint Surgery. American Volume
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