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https://www.readbyqxmd.com/read/28929313/an-anti-propionibacterium-acnes-antibody-shows-heterologous-resistance-to-an-actinobacillus-pleuropneumoniae-infection-independent-of-neutrophils-in-mice
#1
Jian-Fang Liu, Qiu-Yue Ma, Ri-Ning Zhu, Meng-Jun Cheng, Chun-Tong Bao, Jing-Min Gu, Chang-Jiang Sun, Paul Richard Langford, Wen-Yu Han, Lian-Cheng Lei
Porcine contagious pleuropneumonia is a highly fatal respiratory disease that is caused by Actinobacillus pleuropneumoniae (APP) and results in tremendous economic losses for the pig breeding industry worldwide. Previous studies have demonstrated that Propionibacterium acnes (PA) could effectively prevent APP infection in mice and pigs. The humoral immune response played a primary role during this process and anti-PA antibody could mediate macrophages to kill the bacteria. However, the role of neutrophils in this process is currently unknown...
September 20, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28926595/the-microbiota-of-water-buffalo-milk-during-mastitis
#2
Carlotta Catozzi, Armand Sanchez Bonastre, Olga Francino, Cristina Lecchi, Esterina De Carlo, Domenico Vecchio, Alessandra Martucciello, Pasquale Fraulo, Valerio Bronzo, Anna Cuscó, Sara D'Andreano, Fabrizio Ceciliani
The aim of this study was to define the microbiota of water buffalo milk during sub-clinical and clinical mastitis, as compared to healthy status, by using high-throughput sequencing of the 16S rRNA gene. A total of 137 quarter samples were included in the experimental design: 27 samples derived from healthy, culture negative quarters, with a Somatic Cell Count (SCC) of less than 200,000 cells/ml; 27 samples from quarters with clinical mastitis; 83 samples were collected from quarters with subclinical mastitis, with a SCC number greater of 200,000 cells/ml and/or culture positive for udder pathogens, without clinical signs of mastitis...
2017: PloS One
https://www.readbyqxmd.com/read/28920854/in-vitro-activity-of-tedizolid-and-comparator-agents-against-gram-positive-pathogens-responsible-for-bone-and-joint-infections
#3
Pauline Ract, Caroline Piau-Couapel, Fabrice Compain, Michel Auzou, Jocelyn Michon, Vincent Cattoir
Tedizolid, a second-generation oxazolidinone that displays a potent activity against Gram-positive pathogens, could be an interesting option for the treatment of bone and joint infections (BJIs). The aim of the study was to determine minimal inhibitory concentration (MIC) of tedizolid against a collection of 359 clinical isolates involved in clinically-documented BJIs and to compare them to those of comparator agents used in Gram-positive infections. Of the 104 Staphylococcus aureus and 102 coagulase-negative staphylococci (CoNS) isolates, 99 and 92 % were categorized as susceptible to tedizolid, respectively (MIC25=0...
September 18, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28911620/composition-of-asarum-heterotropoides-var-mandshuricum-radix-oil-from-different-extraction-methods-and-activities-against-human-body-odor-producing-bacteria
#4
A S M Tanbirul Haque, Jin Nam Moon, P S Saravana, Adane Tilahun, Byung-Soo Chun
In this study, oils from Asarum heterotropoides were extracted by traditional solvent extraction and supercritical CO2 (SC-CO2) extraction methods and their antioxidant activities along with antimicrobial and inhibitory activities against five human body odor-producing bacteria (Staphylococcus epidermidis, Propionibacterium freudenreichii, Micrococcus luteus, Corynebacterium jeikeium, and Corynebacterium xerosis) were evaluated. The oil was found to contain 15 components, among which the most abundant component was methyl eugenol (37...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911609/antibacterial-and-laxative-activities-of-strictinin-isolated-from-pu-er-tea-camellia-sinensis
#5
Sheng-Kuo Hsieh, Jun-Rui Xu, Nan-Hei Lin, Yue-Chiun Li, Guan-Heng Chen, Ping-Chung Kuo, Wen-Ying Chen, Jason T C Tzen
Strictinin, the major phenolic compound in Pu'er teas produced from young leaves and buds of wild trees, was isolated to evaluate its antibacterial and laxative activities. The minimum inhibitory concentrations of strictinin against Propionibacterium acnes and Staphylococcus epidermidis were determined as 250 μM and 2000 μM, respectively, apparently higher than those of several antibiotics commonly used for bacterial infections. The additive and synergistic effects on the inhibitory activities of strictinin combined with other commercial antibiotics were observed in two bacteria tested in this study via the analysis of fractional inhibitory concentrations...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28902005/propionibacterium-acnes
#6
Inês Marques Carneiro, Ana Sousa Pereira, Sara Pinto, Filipa Prata, Cláudia C Faria, José Gonçalo Marques
Infection after implantation of ventriculo-peritoneal (VP) shunts is associated with significant morbidity and mortality. We describe a 9-year-old girl with Propionibacterium acnes shunt infection with negative cerebrospinal fluid cultures, diagnosed by broad-range 16S-rRNA gene PCR. This case supports the use of this molecular diagnostic technique in shunt infections, where the offending pathogens are difficult to culture using traditional methods.
September 7, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28895889/the-skin-bacterium-propionibacterium-acnes-employs-two-variants-of-hyaluronate-lyase-with-distinct-properties
#7
Seven Nazipi, Kristian Stødkilde-Jørgensen, Carsten Scavenius, Holger Brüggemann
Hyaluronic acid (HA) and other glycosaminoglycans are extracellular matrix components in the human epidermis and dermis. One of the most prevalent skin microorganisms, Propionibacterium acnes, possesses HA-degrading activity, possibly conferred by the enzyme hyaluronate lyase (HYL). In this study, we identified the HYL of P. acnes and investigated the genotypic and phenotypic characteristics. Investigations include the generation of a P. acneshyl knockout mutant and HYL activity assays to determine the substrate range and formed products...
September 12, 2017: Microorganisms
https://www.readbyqxmd.com/read/28890180/effectiveness-of-meibomian-gland-massage-combined-with-topical-levofloxacin-against-ocular-surface-flora-in-patients-before-penetrating-ocular-surgery
#8
Shao Dan Zhang, Jing Na He, Tong Tong Niu, Shan Shan Liu, Chiu Yeung Chan, Chun Yang Ren, Chi Liu, Chi Pui Pang, Yang Qu, Ruo Xi Li, Hai Lin Wang
OBJECTIVE: To investigate the bacterial profile in the conjunctiva and meibomian glands in patients before penetrating ocular surgeries, and to compare the anti-bacterial efficacy of 0.5% levofloxacin and its combination with meibomian gland massage. DESIGN: Hospital-based, case-control study. PARTICIPANTS: Two hundred and twenty-six eyes from 226 patients with non-infective ocular diseases and scheduled for penetrating ocular surgeries. METHODS: Tested eyes were administered with topical 0...
September 7, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28889933/bacterial-conjugated-linoleic-acid-production-and-their-applications
#9
REVIEW
Bo Yang, He Gao, Catherine Stanton, R Paul Ross, Hao Zhang, Yong Q Chen, Haiqin Chen, Wei Chen
Conjugated linoleic acid (CLA) has been shown to exert various potential physiological properties including anti-carcinogenic, anti-obesity, anti-cardiovascular and anti-diabetic activities, and consequently has been considered as a promising food supplement. Bacterial biosynthesis of CLA is an attractive approach for commercial production due to its high isomer-selectivity and convenient purification process. Many bacterial species have been reported to convert free linoleic acid (LA) to CLA, hitherto only the precise CLA-producing mechanisms in Propionibacterium acnes and Lactobacillus plantarum have been illustrated completely, prompting the development of recombinant technology used in CLA production...
September 7, 2017: Progress in Lipid Research
https://www.readbyqxmd.com/read/28888227/conversion-of-an-inactive-xylose-isomerase-into-a-functional-enzyme-by-co-expression-of-groel-groes-chaperonins-in-saccharomyces-cerevisiae
#10
Beatriz Temer, Leandro Vieira Dos Santos, Victor Augusti Negri, Juliana Pimentel Galhardo, Pedro Henrique Mello Magalhães, Juliana José, Cidnei Marschalk, Thamy Lívia Ribeiro Corrêa, Marcelo Falsarella Carazzolle, Gonçalo Amarante Guimarães Pereira
BACKGROUND: Second-generation ethanol production is a clean bioenergy source with potential to mitigate fossil fuel emissions. The engineering of Saccharomyces cerevisiae for xylose utilization is an essential step towards the production of this biofuel. Though xylose isomerase (XI) is the key enzyme for xylose conversion, almost half of the XI genes are not functional when expressed in S. cerevisiae. To date, protein misfolding is the most plausible hypothesis to explain this phenomenon...
September 9, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28887423/forensic-human-identification-using-skin-microbiomes
#11
Sarah E Schmedes, August E Woerner, Bruce Budowle
The human microbiome contributes significantly to the genetic content of the human body. Genetic and environmental factors help shape the microbiome, and as such, the microbiome can be unique to an individual. Previous studies have demonstrated the potential to use microbiome profiling for forensic applications, however a method has yet to identify stable features of skin microbiomes that produce high classification accuracies for samples collected over reasonably long time intervals. A novel approach is described to classify skin microbiomes to their donors by comparing two features types, Propionibacterium acnes pangenome presence/absence features and nucleotide diversities of stable clade-specific markers...
September 8, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28884220/inflammatory-response-of-disc-cells-against-propionibacterium-acnes-depends-on-the-presence-of-lumbar-modic-changes
#12
Stefan Dudli, S Miller, S Demir-Deviren, J C Lotz
PURPOSE: Intervertebral disc with Propionibacterium acnes (P. acnes) is suggested to be an etiology of Modic type I changes in the adjacent bone marrow. However it is unknown if disc cells can respond to P. acnes and if bone marrow cells respond to bacterial and disc metabolites draining from infected discs. METHODS: Human disc cells (n = 10) were co-cultured with 10- and 100-fold excess of P. acnes over disc cells for 3 h and 24 h. Lipopolysaccharide was used as positive control...
September 7, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28883276/acute-exacerbation-of-organizing-pneumonia-leading-to-sudden-death-in-a-patient-with-sarcoidosis-lymphoma-syndrome
#13
Kazuhide Iizuka, Jun Ando, Azuchi Masuda, Tomonori Ochiai, Ran Tomomasa, Hajime Yasuda, Tomoiku Takaku, Yasunori Ota, Takashi Yao, Akihiko Gotoh, Norio Komatsu
The subject was an 83-year-old female; she had a history of Propionibacterium acnes-related sarcoidosis at the age of 79 years. At diagnosis, she was treated with clarithromycin and achieved remission. Four years later, during a routine physical check-up, she presented with pulmonary opacities and swelling of multiple lymph nodes. A definitive diagnosis of lymphoma could not be made by inguinal lymph node biopsy. The patient's general condition was good, and we observed her clinical course. Oh the 56th day of her illness, she died suddenly...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28875271/comparative-effects-of-schisandrin-a-b-and-c-on-acne-related-inflammation
#14
Miaomiao Guo, Faliang An, Xing Wei, Minhua Hong, Yanhua Lu
Inflammatory responses induced by Propionibacterium acnes are a major etiological factor in the pathogenesis of acne vulgaris. Schisandrin A, schisandrin B, and schisandrin C are the representative lignans of Schisandra chinensis (Turcz.) Baill. extract. Although anti-inflammatory effects of the lignans have been shown, their effects on acne-related inflammation caused by P. acnes have not been investigated and compared. We pretreated THP-1 human monocytic cells with 5, 10, and 20 μM schisandrin A, B, and C, and stimulated the cells with P...
September 5, 2017: Inflammation
https://www.readbyqxmd.com/read/28875126/postoperative-deep-shoulder-infections-following-rotator-cuff-repair
#15
REVIEW
Kivanc Atesok, Peter MacDonald, Jeff Leiter, Sheila McRae, Greg Stranges, Jason Old
Rotator cuff repair (RCR) is one of the most commonly performed surgical procedures in orthopaedic surgery. The reported incidence of deep soft-tissue infections after RCR ranges between 0.3% and 1.9%. Deep shoulder infection after RCR appears uncommon, but the actual incidence may be higher as many cases may go unreported. Clinical presentation may include increasing shoulder pain and stiffness, high temperature, local erythema, swelling, warmth, and fibrinous exudate. Generalized fatigue and signs of sepsis may be present in severe cases...
August 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28874721/aging-related-changes-in-the-diversity-of-women-s-skin-microbiomes-associated-with-oral-bacteria
#16
Nakako Shibagaki, Wataru Suda, Cecile Clavaud, Philippe Bastien, Lena Takayasu, Erica Iioka, Rina Kurokawa, Naoko Yamashita, Yasue Hattori, Chie Shindo, Lionel Breton, Masahira Hattori
Skin aging is associated with changes in cutaneous physiology including interactions with a skin microbial community. A striking alteration and diversification in the skin microbiome with aging was observed between two different age groups of 37 healthy Japanese women, i.e. younger adults of 21-37 years old and older adults of 60-76 years old, using bacterial 16S rRNA gene sequencing. The analyses revealed that the alpha diversity/species richness was significantly higher in the older than the younger group for the cheek and forehead microbiomes, while the beta diversity in the overall structure significantly differed particularly for the forearm and scalp microbiomes between the two age groups...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28865964/routine-cultures-for-seemingly-aseptic-revision-shoulder-arthroplasty-are-they-necessary
#17
REVIEW
Tyler J Brolin, Daniel J Hackett, Joseph A Abboud, Jason E Hsu, Surena Namdari
Propionibacterium acnes has recently gained attention as the leading cause of periprosthetic joint infections (PJIs) after shoulder arthroplasty. Unlike PJIs in the lower extremity, PJIs after shoulder arthroplasty usually have an indolent course and are notoriously difficult to diagnose. Most of the time, the diagnosis is made after positive intraoperative cultures are taken at the time of revision surgery. Adding even more complexity to the diagnosis is the high rate of P acnes-positive cultures taken at the time of primary shoulder surgery...
August 30, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28864077/phenotype-and-antimicrobial-activity-of-th17-cells-induced-by-propionibacterium-acnes-strains-associated-with-healthy-and-acne-skin
#18
George W Agak, Stephanie Kao, Kelsey Ouyang, Min Qin, David Moon, Ahsan Butt, Jenny Kim
Studies of human skin microbiome suggest that Propionibacterium acnes strains may contribute differently to skin health and disease. However, the immune phenotype and functions of Th17 cells induced by healthy (PH) vs. acne (PA) skin-associated P. acnes strains are currently unknown. We stimulated PBMCs from healthy donors and observed that PA strains induce higher IL-17 levels than PH strains. We next generated PH and PA strain-specific Th17 clones and show that P. acnes strains induce Th17 cells of varied phenotype and function that are stable in the presence of IL-2 and IL-23...
August 29, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28859990/immune-discrepancies-during-in%C3%A2-vitro-granuloma-formation-in-response-to-cutibacterium-formerly-propionibacterium-acnes-infection
#19
Guillaume Ghislain Aubin, Grâce Ada Da Silva, Yoshinobu Eishi, Cédric Jacqueline, Frédéric Altare, Stéphane Corvec, Karim Asehnoune
Cutibacterium (formerly Propionibacterium) acnes is involved in chronic/low-grade pathologies such as sarcoidosis or prosthetic joint infection (PJI). In these diseases, granulomatous structures are frequently observed. In this study, we induced a physiological granulomatous reaction in response to different well-characterized clinical C. acnes isolates in order to investigate the cellular process during granuloma formation. Three C. acnes isolates selected according to their origin (PJI, sarcoidosis and acne) were typed by MLST...
August 30, 2017: Anaerobe
https://www.readbyqxmd.com/read/28856906/effect-of-propionibacterium-acidipropionici-p169-on-the-rumen-and-faecal-microbiota-of-beef-cattle-fed-a-maize-based-finishing-diet
#20
E Azad, N Narvaez, H Derakhshani, A Y Allazeh, Y Wang, T A McAllister, E Khafipour
Direct fed microbial supplementation with lactic acid utilising bacteria (i.e. Propionibacterium acidipropionici P169) has been shown to alleviate the severity of subacute ruminal acidosis in high-grain fed beef cattle. This study was carried out to explore the impact of P169 supplementation on modulating rumen and hindgut microbiota of high-grain fed steers. Seven ruminally-canulated high-grain fed steers were randomly assigned to two treatment groups: control diet (n=3) and the same diet supplemented with P169 added at a rate of 1×10(11) cfu/head/d (n=4)...
August 31, 2017: Beneficial Microbes
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