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https://www.readbyqxmd.com/read/28087166/future-surgery-after-revision-shoulder-arthroplasty-the-impact-of-unexpected-positive-cultures
#1
Eric M Padegimas, Cassandra Lawrence, Alexa C Narzikul, Benjamin M Zmistowski, Joseph A Abboud, Gerald R Williams, Surena Namdari
BACKGROUND: The clinical implications and treatment of unexpected positive cultures (UPCs) in revision shoulder arthroplasty are not well defined. The purpose of this study was to describe results of patients with and without UPCs after revision shoulder arthroplasty. METHODS: A single institutional database was used to retrospectively identify all revision shoulder arthroplasties performed between January 1, 2011, and December 31, 2013. Patients with preoperative suspicion of infection were excluded...
January 10, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28081259/frequency-of-propionibacterium-acnes-infection-in-prostate-glands-with-negative-biopsy-results-is-an-independent-risk-factor-for-prostate-cancer-in-patients-with-increased-serum-psa-titers
#2
Tomoya Kakegawa, Yuan Bae, Takashi Ito, Keisuke Uchida, Masaki Sekine, Yutaka Nakajima, Asuka Furukawa, Yoshimi Suzuki, Jiro Kumagai, Takumi Akashi, Yoshinobu Eishi
BACKGROUND: Propionibacterium acnes has recently been implicated as a cause of chronic prostatitis and this commensal bacterium may be linked to prostate carcinogenesis. The occurrence of intracellular P. acnes infection in prostate glands and the higher frequency of P. acnes-positive glands in radical prostatectomy specimens from patients with prostate cancer (PCa) than in those from patients without PCa led us to examine whether the P. acnes-positive gland frequency can be used to assess the risk for PCa in patients whose first prostate biopsy, performed due to an increased prostate-specific antigen (PSA) titer, was negative...
2017: PloS One
https://www.readbyqxmd.com/read/28077337/stress-hormone-epinephrine-adrenaline-and-norepinephrine-noradrenaline-effects-on-the-anaerobic-bacteria
#3
REVIEW
Lyudmila Boyanova
Microbial endocrinology is a relatively new research area that already encompasses the anaerobes. Stress hormones, epinephrine and norepinephrine, can affect the growth of anaerobic bacteria such as Fusobacterium nucleatum, Prevotella spp., Porhyromonas spp., Tanerella forsythia and Propionibacterium acnes and can increase virulence gene expression, iron acquisition and many virulence factors of some anaerobic species such as Clostridium perfringens, Porphyromonas gingivalis and Brachyspira pilosicoli. Epinephrine and norepinephrine effects can lead to a growth increase or decrease, or no effect on the growth of the anaerobes...
January 8, 2017: Anaerobe
https://www.readbyqxmd.com/read/28077143/pregnant-women-carrying-microcephaly-foetuses-and-zika-virus-contain-potentially-pathogenic-microbes-and-parasites-in-their-amniotic-fluid
#4
Diogo Antonio Tschoeke, Louisi Souza de Oliveira, Luciana Leomil, Amilcar Tanuri, Fabiano Lopes Thompson
BACKGROUND: Microcephaly has become a major public health problem in Brazil. The total number of newborns with microcephaly was reported to be >4000 in June 2016. Studies suggest that Zika Virus is a major cause of new microcephaly cases in Brazil. Inside the uterus, the foetus is surrounded by the Amniotic Fluid, a proximal fluid that contains foetal and maternal cells as well as microorganisms and where Zika Virus was already found. CASE PRESENTATION: A previous study reported the presence of the Zika Virus in the amniotic fluid (collected in the 28th gestational week) of two pregnant women carrying microcephaly foetuses in Brazil...
January 11, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28076744/modern-management-of-acne
#5
Alan J Cooper, Victoria Rebecca Harris
Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production; altered keratinisation; bacterial colonisation of hair follicles on the face, neck, chest and back by Propionibacterium acnes; and an inflammatory response in the skin. The exact way these processes interact and the order in which they occur in the pathogenesis of acne are still unclear. Scarring that occurs from acne, particularly severe acne, can persist a lifetime and have long lasting psychosocial effects...
January 16, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28065868/clinical-impact-of-positive-propionibacterium-acnes-cultures-in-orthopedic-surgery
#6
Valery Lavergne, Michel Malo, Cinzia Gaudelli, Michelle Laprade, Stéphane Leduc, Pierre Laflamme, Dominique M Rouleau
BACKGROUND: The clinical significance of a positive culture to Propionibacterium acnes in orthopedic specimens remains unclear, whether about its role as a contaminant or a pathogen, or its impact as a coinfectant. Therefore we performed a retrospective study to provide a more accurate description of the clinical impact of P.acnes in an orthopedic population aiming to determine: 1) if there is a clinical difference between P.acnes infection and contamination? 2) if there is a clinical difference between P...
January 5, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28057559/propionibacterium-acnes-endocarditis-a-case-series
#7
Jona M Banzon, Susan J Rehm, Steven M Gordon, Syed T Hussain, Gosta B Pettersson, Nabin K Shrestha
OBJECTIVES: Propionibacterium acnes remains a rare cause of infective endocarditis (IE). It is challenging to diagnose due to the organism's fastidious nature and the indolent presentation of the disease. The purpose of this study was to describe the clinical presentation and management of P. acnes IE with an emphasis on the methods of diagnosis. METHODS: We identified patients from the Cleveland Clinic Infective Endocarditis Registry who were admitted from 2007 to 2015 with definite IE by Duke Criteria...
January 2, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28038423/citric-acid-application-for-denitrification-process-support-in-biofilm-reactor
#8
Artur Mielcarek, Joanna Rodziewicz, Wojciech Janczukowicz, Dorota Dabrowska, Slawomir Ciesielski, Arthur Thornton, Joanna Struk-Sokołowska
The study demonstrated that citric acid, as an organic carbon source, can improve denitrification in Anaerobic Sequencing Batch Biofilm Reactor (AnSBBR). The consumption rate of the organic substrate and the denitrification rate were lower during the period of the reactor's acclimatization (cycles 1-60; 71.5 mgCOD L(-1) h(-1) and 17.81 mgN L(-1) h(-1), respectively) than under the steady state conditions (cycles 61-180; 143.8 mgCOD L(-1) h(-1) and 24.38 mgN L(-1) h(-1)). The biomass yield coefficient reached 0...
December 22, 2016: Chemosphere
https://www.readbyqxmd.com/read/28033675/bacteriophage-formulated-into-a-range-of-semisolid-and-solid-dosage-forms-maintain-lytic-capacity-against-isolated-cutaneous-and-opportunistic-oral-bacteria
#9
Teagan L Brown, Tereen Thomas, Jessica Odgers, Steve Petrovski, Marion Joy Spark, Joseph Tucci
BACKGROUND: Resistance of bacteria to antimicrobial agents is of grave concern. Further research into the development of bacteriophage as therapeutic agents against bacterial infections may help alleviate this problem. OBJECTIVES: To formulate bacteriophage into a range of semisolid and solid dosage forms and investigate the capacity of these preparations to kill bacteria under laboratory conditions. METHODS: Bacteriophage suspensions were incorporated into dosage forms such as creams, ointments, pastes, pessaries and troches...
December 29, 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28024924/recognition-of-propionibacterium-acnes-by-human-tlr2-heterodimers
#10
Qi Su, Maria Grabowski, Günther Weindl
Propionibacterium acnes has been considered as a crucial contributor to the pathogenesis of acne vulgaris. The interaction between P. acnes and the host is mainly mediated by Toll like receptor (TLR) 2 recognition. TLR2 homodimers recognize P. acnes in mice, but here we describe the prerequisite of TLR2/1 and TLR2/6 heterodimers in human cells for P. acnes recognition. P. acnes-induced NF-κB and AP-1activation observed in HEK hTLR2-transfected but not control cells confirmed the specificity of TLR2 recognition...
December 12, 2016: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28013413/selective-persistence-of-propionibacterium-species-fma5-following-sealing-of-infected-dentinal-matrix
#11
M A Nadkarni, K Angner, N Hunter
The objective of the present study was to test the hypothesis that nutrient deprivation by effective isolation should inactivate causative saccharolytic bacteria occupying carious lesions. Vital maxillary third molar teeth were prepared by removing only the superficial necrotic material, leaving behind infected dentinal matrix, before the cavity was sealed with glass ionomer cement (GIC). Before sealing, lesions were biopsied to provide reference bacterial DNA for microbial analysis. After an interval of 10-12 months, the teeth were extracted and, after careful removal of GIC restoration, the underlying dentine was biopsied again for post-treatment microbial analysis...
December 24, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28002380/propionibacterium-we-found-it-now-we-have-to-deal-with-it-commentary-on-an-article-by-jason-e-hsu-md-et-al-single-stage-revision-is-effective-for-failed-shoulder-arthroplasty-with-positive-cultures-for-propionibacterium
#12
Philipp Moroder, Andrej Trampuz, Markus Scheibel
No abstract text is available yet for this article.
December 21, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28002367/single-stage-revision-is-effective-for-failed-shoulder-arthroplasty-with-positive-cultures-for-propionibacterium
#13
Jason E Hsu, Jacob D Gorbaty, Ian J Whitney, Frederick A Matsen
BACKGROUND: Revision shoulder arthroplasties are often culture-positive for Propionibacterium. This study tests the hypothesis that the functional outcomes of revising Propionibacterium culture-positive failed arthroplasties with a single-stage revision and immediate antibiotic therapy are not inferior to the clinical outcomes of revising failed shoulder arthroplasties that are not culture-positive. METHODS: Fifty-five shoulders without obvious clinical evidence of infection had a single-stage revision arthroplasty...
December 21, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28000755/the-balance-of-metagenomic-elements-shapes-the-skin-microbiome-in-acne-and-health
#14
Emma Barnard, Baochen Shi, Dezhi Kang, Noah Craft, Huiying Li
Studies have emphasized the importance of disease-associated microorganisms in perturbed communities, however, the protective roles of commensals are largely under recognized and poorly understood. Using acne as a model disease, we investigated the determinants of the overall virulence property of the skin microbiota when disease- and health-associated organisms coexist in the community. By ultra-deep metagenomic shotgun sequencing, we revealed higher relative abundances of propionibacteria and Propionibacterium acnes phage in healthy skin...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27992149/verantwortlicher-umgang-mit-antibiotika-notwendigkeit-der-antibiotikareduktion-in-der-aknetherapie
#15
Harald P M Gollnick, Jan Buer, Stefan Beissert, Cord Sunderkätter
Der übermäßige oder unkritische weltweite Einsatz von Antibiotika in der Medizin hat die Ausbreitung von Antibiotikaresistenzen beschleunigt. In einigen Bereichen sind viele Antibiotika bei bakteriellen Infektionen, die zuvor noch gut auf antibakterielle Wirkstoffe reagierten, mittlerweile wirkungslos geworden. Dermatologen/Venerologen setzten orale und topische Antibiotika bei der Behandlung von Acne vulgaris routinemäßig ein, obwohl Akne weder eine infektiöse Erkrankung ist noch alleine durch das Propionibacterium getriggert wird...
December 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27989720/prevention-of-propionibacterium-acnes-biofilm-formation-in-prosthetic-infections-in-vitro
#16
Robert P Howlin, Christopher Winnard, Elizabeth M Angus, Connor J Frapwell, Jeremy S Webb, John J Cooper, Sean S Aiken, Julie Y Bishop, Paul Stoodley
BACKGROUND: The role of Propionibacterium acnes in shoulder arthroplasty and broadly in orthopedic prosthetic infections has historically been underestimated, with biofilm formation identified as a key virulence factor attributed to invasive isolates. With an often indolent clinical course, P acnes infection can be difficult to detect and treat. This study investigates absorbable cements loaded with a broad-spectrum antibiotic combination as an effective preventive strategy to combat P acnes biofilms...
December 15, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27989048/complicated-infective-endocarditis-of-a-mechanical-aortic-valve-due-to-propionibacterium-acnes
#17
Eva De Caluwé, Jan Verwerft
Propionibacterium acnes is known to be a causative microorganism in low-grade and late prosthetic valve endocarditis. Here, the case is reported of a late, apparently culture-negative endocarditis of an aortic mechanical prosthesis, diagnosed to be caused by P. acnes after pan-bacterial polymerase chain reaction (PCR) on the explanted mechanical prosthetic valve. This endocarditis was complicated by an aortic root abscess; after surgical resection a ventricular septal defect (VSD) with overt right ventricular and multiple organ failure occurred...
May 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27988390/low-antibiotic-resistance-among-anaerobic-gram-negative-bacteria-in-periodontitis-5-years-following-metronidazole-therapy
#18
G Dahlen, H R Preus
The objective of this study was to assess antibiotic susceptibility among predominant Gram-negative anaerobic bacteria isolated from periodontitis patients who 5 years prior had been subject to mechanical therapy with or without adjunctive metronidazole. One pooled sample was taken from the 5 deepest sites of each of 161 patients that completed the 5 year follow-up after therapy. The samples were analyzed by culture. A total number of 85 anaerobic strains were isolated from the predominant subgingival flora of 65/161 patient samples, identified, and tested for antibiotic susceptibility by MIC determination...
December 14, 2016: Anaerobe
https://www.readbyqxmd.com/read/27984454/nonunion-after-clavicle-osteosynthesis-high-incidence-of-propionibacterium-acnes
#19
Elizabeth B Gausden, Jordan Villa, Stephen J Warner, Mariya Redko, Andrew Pearle, Andy Miller, Michael Henry, Dean G Lorich, David L Helfet, David S Wellman
OBJECTIVE: The objective of this study was to review the etiology of clavicle nonunions following osteosynthesis and investigate the outcomes of a treatment with a single stage revision. DESIGN: Retrospective case series SETTING:: Orthopaedic specialty hospital PATIENTS:: Twenty cases of nonunion following osteosynthesis of the clavicle were identified. The average age was 44 years old (+/- 13 years). In nine cases there was catastrophic implant failure that prompted the revision surgery...
December 8, 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27979946/draft-genome-sequences-of-four-propionibacterium-acnes-strains-isolated-from-implant-related-infections
#20
Guillaume Ghislain Aubin, Stanimir Kambarev, Aurélie Guillouzouic, Didier Lepelletier, Pascale Bémer, Stéphane Corvec
Propionibacterium acnes was previously described as a potential implant-related pathogen. Here, we report the draft genome sequence of four P. acnes strains, isolated from spine material, hip arthroplasty, and knee arthroplasty infections in France belonging to different sequence types (ST18, ST27, and ST36).
December 15, 2016: Genome Announcements
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