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https://www.readbyqxmd.com/read/28227736/dermatological-tracking-of-chronic-acne-treatment-effectiveness
#1
Sergiu Lucut, Michael R Smith, Sergiu Lucut, Michael R Smith, Michael R Smith, Sergiu Lucut
Acne can lead to severe physical and psychological implications on chronic sufferers if not treated promptly and properly. Ramli et al. proposed a k-means cluster based algorithm to provide computer-assisted support for the manual grading of digital images. We propose an improved, automated, and more objective, grading method which involves optimizing the k-means clustering algorithm by identifying the actual number of clusters rather than basing analysis on a fixed K= 3 assumption for all images. The Hough transform was used to further analyze the found acne cluster leading to an approach to more accurately automatically determine the number and type of lesions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225994/a-rare-case-of-ectopic-acth-syndrome-originating-from-malignant-renal-paraganglioma
#2
Esra Tutal, Demet Yılmazer, Taner Demirci, Evrim Cakır, Salih Sinan Gültekin, Bahadır Celep, Oya Topaloğlu, Erman Çakal
Ectopic adrenocorticotropic hormone (ACTH) syndrome is characterized by hypercortisolism due to the hypersecretion of a non-pituitary ACTH-secreting tumor leading to Cushing's syndrome. Only a few cases have been reported previously as causing ectopic ACTH related to paraganglioma. Herein, we present a case of Cushing's syndrome, in who was proved to be attributable to an ACTH-secreting renal malignant paraganglioma. A 40-year-old woman presented with a five-month history of newly diagnosed hypertension and diabetes, weakness, hyperpigmentation, oligomenorrhea, hirsutism, and acneiform lesions...
February 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28225954/frequency-severity-and-related-factors-of-androgenetic-alopecia-in-dermatology-outpatient-clinic-hospital-based-cross-sectional-study-in-turkey
#3
Kubra Esen Salman, Ilknur Kivanc Altunay, Nihal Asli Kucukunal, Asli Aksu Cerman
BACKGROUND: Androgenetic alopecia (AGA) is a patterned hair loss occurring due to systemic androgen and genetic factors. It is the most common cause of hair loss in both genders. In recent years, many studies investigating the relation between systemic diseases and androgenetic alopecia presented controversial results. OBJECTIVES: In this study we aimed to investigate the frequency of androgenetic alopecia, the presence of accompanying systemic diseases, the relation between body mass index and androgenetic alopecia severity and the association of hyperandrogenemia signs with androgenetic alopecia in patients who referred to our outpatient clinic...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28224768/comparison-of-the-bruker-biotyper-and-vitek-ms-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-systems-using-a-formic-acid-extraction-method-to-identify-common-and-uncommon-yeast-isolates
#4
Hyun Seung Lee, Jong Hee Shin, Min Ji Choi, Eun Jeong Won, Seung Jung Kee, Soo Hyun Kim, Myung Geun Shin, Soon Pal Suh
BACKGROUND: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) allows rapid and accurate identification of clinical yeast isolates. In-tube formic acid/acetonitrile (FA/ACN) extraction is recommended prior to the analysis with MALDI Biotyper, but the direct on-plate FA extraction is simpler. We compared the Biotyper with the VITEK MS for the identification of various clinically relevant yeast species, focusing on the use of the FA extraction method...
May 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28223770/infliximab-for-treatment-of-synovitis-acne-pustulosis-hyperostosis-and-osteitis-syndrome-a-case-report
#5
Ayaki Hirohata, Takaaki Hanafusa, Tomoko Kawamoto, Ryuta Ikegami
No abstract text is available yet for this article.
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28223742/insulin-like-growth-factor-1-increases-the-expression-of-inflammatory-biomarkers-and-sebum-production-in-cultured-sebocytes
#6
Hyojin Kim, Sun Young Moon, Mi Yeung Sohn, Weon Ju Lee
BACKGROUND: Acne vulgaris has been linked to the Western diet. Hyperglycemic diet increases insulin and insulin-like growth factor (IGF)-1. Deeper insights into IGF-1-mediated signal pathway are critical importance to understand the impact of Western diet. OBJECTIVE: We investigated the effect of IGF-1 on the expression of inflammatory biomarkers and sebum production in cultured sebocytes. METHODS: Polymerase chain reaction and enzyme-linked immunosorbent assay were performed to measure changes in the expression of inflammatory biomarkers including interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), IGF1R, IGFBP2, sterol response element-binding protein (SREBP), and phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PI3KCA) after the treatment of cultured sebocytes with 10(-7) M or 10(-5) M IGF-1...
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28222919/specific-infectious-organisms-associated-with-poor-outcomes-in-treatment-for-hip-periprosthetic-infection
#7
Daniel J Cunningham, Joseph J Kavolus, Michael P Bolognesi, Samuel S Wellman, Thorsten M Seyler
BACKGROUND: Periprosthetic hip infection treatment remains a significant challenge for orthopedics. Some studies have suggested that methicillin resistance and gram-negative organism type are associated with increased treatment failure. The aim of this research is to determine if specific organisms were associated with poor outcomes in treatment for hip periprosthetic infection. METHODS: Records were reviewed of all patients between 2005 and 2015 who underwent treatment for infected partial or total hip arthroplasty...
January 26, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28220628/the-role-of-nicotinamide-in-acne-treatment
#8
REVIEW
Frances M Walocko, Ariel E Eber, Jonette E Keri, Mana A Al-Harbi, Keyvan Nouri
Safe and effective treatment options for acne vulgaris are needed to address side effects and increasing rates of antibiotic resistance from current treatments. Nicotinamide is a vitamin with potent anti-inflammatory properties that could offer a potential treatment option. We aim to summarize the relevant literature on the role of nicotinamide in acne vulgaris and discuss the next steps necessary to move this approach into clinical practice. We searched PubMed for clinical studies using nicotinamide for treatment of acne vulgaris...
February 21, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28220505/fractional-microplasma-radiofrequency-technology-for-non-hypertrophic-post-burn-scars-in-asians-a-prospective-study-of-95-patients
#9
Shen Wang, Jing Mi, Qingfeng Li, Rui Jin, Jiying Dong
BACKGROUND: Laser and other energy devices are emerging, minimally invasive treatments for scars. Among the various techniques, fractional microplasma radiofrequency technology (FMRT) has proven to be an effective treatment option for various types of scars and skin conditions such as rhytids, striae distensae, and hyperpigmentation. OBJECTIVE: This prospective clinical trial was designed to evaluate the efficacy and safety of FMRT for treating non-hypertrophic post-burn scars in the Asian population...
February 20, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28218972/views-of-oral-antibiotics-and-advice-seeking-about-acne-a-qualitative-study-of-online-discussion-forums
#10
M Santer, D Chandler, M Lown, N A Francis, I Muller
BACKGROUND: Acne vulgaris is common and can significantly impair quality of life, yet little is known about patients' understanding of acne and its treatments. Oral antibiotics are widely used for acne, despite concerns about antibiotic resistance. People are increasingly turning to online discussion forums for advice and information on these sites may influence health beliefs and treatment adherence. OBJECTIVE: To explore understandings about the use of oral antibiotics for acne and advice shared amongst messages posted on online forums...
February 20, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28218465/compliance-with-national-guidelines-on-isotretinoin-where-are-we-2-years-since-the-last-audit-results-of-the-national-isotretinoin-re-audit-2014
#11
L S Exton, S T Cheung, A G Brain, M F Mohd Mustapa, D A R de Berker
BACKGROUND: In 2010, the British Association of Dermatologists (BAD) published clinical guidelines for the safe introduction and continued use of isotretinoin in patients with acne in the UK. The BAD provides UK dermatologists with a facility for national audit, and it undertook an audit on compliance with these guidelines in 2012. AIM: To determine current clinical practices relating to use of isotretinoin among dermatologists in the UK (including geographical variations) as measured against BAD standards, and to ascertain any improvement since the 2012 audit...
February 20, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28218305/interaction-of-cutibacterium-%C3%A2-formerly-propionibacterium-acnes-with-bone-cells-a-step-toward-understanding-bone-and-joint-infection-development
#12
Guillaume Ghislain Aubin, Marc Baud'huin, Jean-Philippe Lavigne, Régis Brion, François Gouin, Didier Lepelletier, Cédric Jacqueline, Dominique Heymann, Karim Asehnoune, Stéphane Corvec
Cutibacterium acnes (formerly Propionibacterium acnes) is recognized as a pathogen in foreign-body infections (arthroplasty or spinal instrumentation). To date, the direct impact of C. acnes on bone cells has never been explored. The clade of 11 C. acnes clinical isolates was determined by MLST. Human osteoblasts and osteoclasts were infected by live C. acnes. The whole genome sequence of six isolates of this collection was analyzed. CC36 C. acnes strains were significantly less internalized by osteoblasts and osteoclasts than CC18 and CC28 C...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28218057/propionibacterium-acnes-is-developing-gradual-increase-in-resistance-to-oral-tetracyclines
#13
Keisuke Nakase, Hidemasa Nakaminami, Yuko Takenaka, Nobukazu Hayashi, Makoto Kawashima, Norihisa Noguchi
Propionibacterium acnes is an anaerobic bacterium that causes deep infection in organs and prosthetic joints, in addition to acne vulgaris. Many tetracycline-resistant P. acnes strains have been isolated because oral tetracyclines are frequently used as an acne treatment against P. acnes. In this study, we found a novel tetracycline resistance mechanism in P. acnes. Three doxycycline-resistant (MIC: 16 µg ml-1) strains were isolated from 69 strains in acne patients in Japan between 2010 and 2011. Additionally, six insusceptible strains (MIC: 1-2 µg ml-1) that had reduced susceptibility compared to susceptible strains (MIC: ≤0...
January 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28210389/the-use-of-lipohydroxy-acid-in-skin-care-and-acne-treatment
#14
REVIEW
Joshua A Zeichner
Lipohydroxy acid is a derivative of salicylic acid with unique properties that explain its clinical effects in the skin. Lipohydroxy acid has skin renewing, exfoliating, and acne treating properties and is a commonly used ingredient in personal skin care products. The slow penetration of lipohydroxy acid results in an individual cell-by-cell exfoliation that is associated with excellent tolerability. Lipohydroxy acid has been shown to induce dermal thickening by stimulating glycosaminoglycans, collagen, and elastin production...
November 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28210380/emerging-issues-in-adult-female-acne
#15
REVIEW
Joshua A Zeichner, Hillary E Baldwin, Fran E Cook-Bolden, Lawrence F Eichenfield, Sheila Fallon-Friedlander, David A Rodriguez
Acne vulgaris (acne) is a common affliction in adolescence and is a growing problem in adult women. Despite an increasing awareness of acne in the adult female population, there is a lack of good prospective studies assessing the severity, distribution, and differential response to treatment in this group. The long-held dogma that acne in adult women develops on the lower one-third of the face has been recently challenged, and here the authors critically review data from available literature. Moreover, while adult female acne has traditionally been defined as disease in women over age 25, it is the authors' experience that this group is subdivided into women ages 25 to 44 years, separate from perimenopausal patients, ages 45 years and up...
January 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28208874/topical-corticosteroid-misuse-the-scenario-in-patients-attending-a-tertiary-care-hospital-in-new-delhi
#16
Santwana Mahar, Khushbu Mahajan, Swati Agarwal, Hemanta Kumar Kar, Swapan Kumar Bhattacharya
INTRODUCTION: Irrational use of Topical Corticosteroid (TC) is quite common in India due to unrestricted availability and use of TC not only by general public but also by physicians and chemists due to quick relief of symptoms in different dermatological conditions. AIM: The present study was conducted to evaluate and analyse the prevalence of misuse of TC and the causes behind misuse of TC among patients in a dermatology outpatient department in New Delhi. MATERIALS AND METHODS: This was a cross-sectional observational questionnaire based study conducted over a period of 5 months (1(st) June 2015 to 30(th) November 2015)...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208738/oral-administration-of-the-japanese-traditional-medicine-keishibukuryogan-ka-yokuinin-decreases-reactive-oxygen-metabolites-in-rat-plasma-identification-of-chemical-constituents-contributing-to-antioxidant-activity
#17
Yosuke Matsubara, Takashi Matsumoto, Kyoji Sekiguchi, Junichi Koseki, Atsushi Kaneko, Takuji Yamaguchi, Yumiko Kurihara, Hiroyuki Kobayashi
Insufficient detoxification and/or overproduction of reactive oxygen species (ROS) induce cellular and tissue damage, and generated reactive oxygen metabolites become exacerbating factors of dermatitis. Keishibukuryogan-ka-yokuinin (KBGY) is a traditional Japanese medicine prescribed to treat dermatitis such as acne vulgaris. Our aim was to verify the antioxidant properties of KBGY, and identify its active constituents by blood pharmacokinetic techniques. Chemical constituents were quantified in extracts of KBGY, crude components, and the plasma of rats treated with a single oral administration of KBGY...
February 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28207416/are-aromatase-inhibitors-in-boys-with-predicted-short-stature-and-or-rapidly-advancing-bone-age-effective-and-safe
#18
Jessica A Ferris, Mitchell E Geffner
BACKGROUND: The aim of this study was to assess aromatase inhibitor (AI) efficacy in increasing predicted adult height (PAH) and to describe clinical and biochemical safety profiles of AI-treated boys. METHODS: A retrospective chart review was conducted at an academic children's hospital endocrinology clinic. Twenty-one boys with predicted short stature and/or rapidly advancing bone age, divided as Tanner stage (TS) I-III Group 1 (G1, n=9) and TS IV-V Group 2 (G2, n=12), were treated with AIs, either letrozole or anastrozole (mean duration, G1: 2...
February 16, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28203623/pyoderma-gangrenosum-acne-and-hidradenitis-suppurativa-pash-syndrome-with-recurrent-vasculitis
#19
Dorene Niv, James A Ramirez, David P Fivenson
No abstract text is available yet for this article.
January 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28198759/how-specialty-certification-influences-professional-practice
#20
Sharon Vanairsdale
Certified Nurses Day (March 19) honors nurses worldwide who contribute to better patient outcomes through board certification in their specialty. In this month's Magnet® Perspectives column, Sharon Vanairsdale, MS, APRN, ACNS-BC, NP-C, CEN, program director for Emory University Hospital's Serious Communicable Diseases Unit, discusses the value of certification, what it means to her professional practice, and how it helps to champion her work. Ms Vanairsdale is triple certified as a certified emergency nurse, an adult clinical nurse specialist, and an adult nurse practitioner...
March 2017: Journal of Nursing Administration
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