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https://www.readbyqxmd.com/read/28628832/young-leaves-of-reed-phragmites-communis-suppress-melanogenesis-and-oxidative-stress-in-b16f10-melanoma-cells
#1
Mi-Ok Sim, Ju Ri Ham, Mi-Kyung Lee
This study investigated the effects young leaves of reed (Phragmites communis) water extract (YLR) on melanogenesis and oxidative stress using B16F10 cells. YLR decreased the intracellular melanin content, protein expression and enzyme activity of tyrosinase in a dose-dependent manner. YLR significantly decreased the gene and protein expression of melanogeneis-related proteins, such as microphthalmia-associated transcription factor (MITF), and tyrosinase-related protein-1 and -2. In addition, YLR up-regulated the melanogenesis inhibitory proteins, extracellular signal-regulated kinase (ERK) and protein kinase B (AKT), while it dose-dependently down-regulated p38 and cAMP response element-binding protein (CREB)...
June 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28621833/multiple-external-cervical-root-resorptions-after-home-bleaching-treatment-with-22-carbamide-peroxide
#2
Glauco Rodrigues Velloso, Marcos Motta de Freitas, Adriana Terezinha Neves Novellino Alves, Alan Roger Santos Silva, Eliane Dos Santos Porto Barboza, Vittorio Moraschini
Invasive multiple cervical root resorptions after vital tooth bleaching is a rare condition. The aim of this article is to present a case of multiple external cervical root resorptions (ECRR) after a misguided home whitening treatment. A 34-year-old male patient presented with slight sensitivity and mobility in several teeth. Despite the manufacturer's recommendations, the patient used a 22% carbamide peroxide-based tooth bleaching gel at home for 4 consecutive days, at night, on the upper and lower arches...
June 16, 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/28619537/synthesis-and-biological-evaluation-of-caffeic-acid-derivatives-as-potent-inhibitors-of-%C3%AE-msh-stimulated-melanogenesis
#3
Hyeju Jo, Minho Choi, Jaeuk Sim, Mayavan Viji, Siyuan Li, Young Hee Lee, Youngsoo Kim, Seung-Yong Seo, Yuanyuan Zhou, Kiho Lee, Wun-Jae Kim, Jin Tae Hong, Heesoon Lee, Jae-Kyung Jung
We have disclosed our effort to develop caffeic acid derivatives as potent and non-toxic inhibitors of α-MSH-stimulated melanogenesis to treat pigmentation disorders and skin medication including a cosmetic skin-whitening agent. The SAR studies revealed that cyclohexyl ester and secondary amide derivatives of caffeic acid showed significant inhibitory activities.
June 3, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28598022/skin-resistance-to-uvb-induced-oxidative-stress-and-hyperpigmentation-by-the-topical-use-of-lactobacillus-helveticus-ns8-fermented-milk-supernatant
#4
Jingjing Rong, Chuang Shan, Shuzhan Liu, Houfeng Zheng, Chen Liu, Ming Liu, Feng Jin, Li Wang
AIMS: Here, we investigated the preventive properties of the supernatant of Lactobacillus helveticus NS8-fermented milk (NS8-FS) against UV light-induced skin oxidative damage and hyperpigmentation. METHODS AND RESULTS: NS8-FS exhibited significant radical scavenging activity in tests with ABST(+) and DPPH scavenging methods, and as well strongly inhibited 3-morpholinosydnonimine (Sin-1) induced ROS generation in HaCat keratinocytes. Unexpectedly, NS8-FS was found to inhibit melanin production in B16F10 melanoma cells, and to exhibit inhibitory effects both to the enzymatic activity of tyrosinase and the expression of proteins required for melanin synthesis...
June 9, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28594936/climatic-and-drought-characteristics-in-the-loess-hilly-gully-region-of-china-from-1957-to-2014
#5
Xingkai Zhao, Zengyao Li, Qingke Zhu, Danhong Zhu, Huifang Liu
The loess hilly-gully region is a focus region of the "Grain for Green" program in China. Drought is the main problem in the study region. Precipitation and temperature are two indicators that directly characterize climatic drought. A thorough analysis of the precipitation, temperature and drought characteristics of the loess hilly-gully region can clarify the current water and heat conditions in the region to improve regional water resource management and provide a reliable reference for effectively improving water use efficiency...
2017: PloS One
https://www.readbyqxmd.com/read/28586027/inhibitory-effects-of-stichopus%C3%A2-japonicus-extract-on-melanogenesis-of-mouse-cells-via-erk-phosphorylation
#6
Chang Taek Oh, Tae-Rin Kwon, Yu-Jin Jang, Kwang Ho Yoo, Beom Joon Kim, Heesu Kim
Stichopus japonicus has been used as a folk medicine and as an ingredient in traditional food in East Asian countries. In recent years, the bioactive compounds found in S. japonicus have been reported to possess efficacy in wound healing and may be of potential use in the cosmeceutical, pharmaceutical and biomedical industries. Although the components and their functions require further investigation, S. japonicus extracts exhibit anti‑inflammatory properties, and may be used for cancer prevention and treatment...
June 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28584573/inhibitory-effect-of-gastrodia-elata-blume-extract-on-alpha-melanocyte-stimulating-hormone-induced-melanogenesis-in-murine-b16f10-melanoma
#7
Eugene Shim, Eunju Song, Kyoung Sook Choi, Hyuk-Joon Choi, Jinah Hwang
BACKGROUND/OBJECTIVES: Gastrodia elata Blume (GEB), a traditional herbal medicine, has been used to treat a wide range of neurological disorders (e.g., paralysis and stroke) and skin problems (e.g., atopic dermatitis and eczema) in oriental medicine. This study was designed to investigate whether GEB extract inhibits melanogenesis activity in murine B16F10 melanoma. MATERIALS/METHOD: Murine B16F10 cells were treated with 0-5 mg/mL of GEB extract or 400 µg/mL arbutin (a positive control) for 72 h after treatment with/without 200 nM alpha-melanocyte stimulating hormone (α-MSH) for 24 h...
June 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28574158/efficacy-and-safety-of-a-new-microneedle-patch-for-skin-brightening-a-randomized-split-face-single-blind-study
#8
Kui Young Park, Hyun Jung Kwon, Changjin Lee, Daegun Kim, Jun Jin Yoon, Myeong Nam Kim, Beom Joon Kim
BACKGROUND: Although microneedles are one of the best transdermal drug delivery systems for active compounds, few clinical trials have examined the safety and efficacy of brightening microneedle patches. AIMS: To determine the efficacy and safety of a newly developed whitening microneedle patch. PATIENTS/METHODS: A split-face study was designed for efficacy assessment with 34 Korean women applying the tested product (a whitening microneedle patch) on one cheek and a control whitening essence on the other...
June 2, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28573755/whitening-dentifrice-and-tooth-surface-discoloration-a-systematic-review-and-meta-analysis
#9
REVIEW
G D Soeteman, C Valkenburg, G A Van der Weijden, C Van Loveren, Ewp Bakker, D E Slot
OBJECTIVE: The aim of this systematic review was to assess the effect of a whitening dentifrice (WDF) relative to a regular dentifrice (RDF) on the reduction of natural extrinsic tooth surface discoloration (ETD). MATERIALS AND METHODS: The MEDLINE-PubMed, Cochrane-CENTRAL and EBSCO-Dentistry and Oral Sciences databases were searched, up to April 2017. The inclusion criteria were as follows:(randomized)controlled clinical trials, healthy subjects ≥18 years of age, studies comparing WDF with RDF, a follow-up period of at least 6 weeks and studies scoring ETD as the stain area/extent, stain intensity or a composite score...
June 2, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28557244/acetazolamide-inhibits-the-level-of-tyrosinase-and-melanin-an-enzyme-kinetic-in-vitro-in-vivo-and-in-silico-studies
#10
Qamar Abbas, Hussain Raza, Mubashir Hassan, Abdul Rehman Phull, Song Ja Kim, Sung-Yum Seo
Melanin is the major factor that determines skin color and protects from ultraviolet radiation. In present study we evaluated the anti-melanogenesis effect of acetazolamide (ACZ) using four different approaches: enzyme kinetic, in vitro, in vivo and in silico. ACZ demonstrated significant inhibitory activity (IC50 7.895 ± 0.24 μM) against tyrosinase as compared to the standard drug kojic acid (IC50 16.84 ± 0.64 μM) and kinetic analyses showed that ACZ is a non-competitive inhibitor without cytotoxic effect...
May 29, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28550862/neutral-bleaching-gel-results-in-similar-whitening-effect-and-postoperative-tooth-sensitivity-as-acid-bleaching-gel
#11
Romina Brignardello-Petersen
No abstract text is available yet for this article.
June 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28541056/visible-spatial-contiguity-of-social-information-and-reward-affects-social-learning-in-brown-capuchins-sapajus-apella-and-children-homo-sapiens
#12
Lara A Wood, Andrew Whiten
Animal social learning is typically studied experimentally by the presentation of artificial foraging tasks. Although productive, results are often variable even for the same species. We present and test the hypothesis that one cause of variation is that spatial distance between rewards and the means of reward release causes conflicts for participants' attentional focus. We investigated whether spatial contiguity between a visible reward and the means of release would affect behavioral responses that evidence social learning, testing 21 brown capuchins (Sapajus apella), a much-studied species with variant evidence for social learning, and one hundred eighty 2- to 4-year-old human children (Homo sapiens), a benchmark species known for a strong social learning disposition...
May 25, 2017: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/28521331/retinal-deep-capillary-ischemia-associated-with-an-occluded-congenital-retinal-macrovessel
#13
Taiji Hasegawa, Nahoko Ogata
PURPOSE: To report the case of a patient with an occluded congenital retinal macrovessel accompanied by retinal deep capillary ischemia. METHODS: A 38-year-old woman presented with a 2-day history of a paracentral scotoma of her right eye. RESULTS: Fundus photograph showed a dilated congenital retinal macrovessel with arteriovenous anastomosis, an intravascular white region indicating the thrombus at arteriovenous anastomotic region, and an area of retinal whitening temporal to the fovea...
July 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28505073/anti-pigmentary-effect-of-4-hydroxysattabacin-from-the-marine-derived-bacterium-bacillus-sp
#14
Kyuri Kim, Alain S Leutou, Haein Jeong, Dayoung Kim, Chi Nam Seong, Sang-Jip Nam, Kyung-Min Lim
Bioactivity-guided isolation of a crude extract from a culture broth of Bacillus sp. has led to the isolation of (-)-4-hydroxysattabacin (1). The inhibitory effect of (-)-4-hydroxysattabacin (1) was investigated on melanogenesis in the murine melanoma cell line, B16F10, and human melanoma cell line, MNT-1, as well as a pigmented 3D-human skin model. (-)-4-Hydroxysattabacin treatment decreased melanin contents in a dose-dependent manner in α-melanocyte stimulating hormone (α-MSH)-stimulated B16F10 cells. Quantitative real time PCR (qRT-PCR) demonstrated that treatment with (-)-4-hydroxysattabacin down-regulated several melanogenic genes, including tyrosinase, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2) while their enzymatic activities were unaffected...
May 13, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28496237/whitening-toothpaste-with-charcoal
#15
(no author information available yet)
No abstract text is available yet for this article.
May 12, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28496230/invasive-cervical-resorption-and-the-oro-facial-cleft-patient-a-review-and-case-series
#16
A O'Mahony, C McNamara, A Ireland, J Sandy, J Puryer
Introduction Invasive cervical resorption (ICR) has an unknown aetiology, yet it exhibits very aggressive behaviour compared with typical external root resorption, posing a high risk of tooth loss.Aim To investigate the number of patients at the Dublin Cleft Prosthodontic Department with an oro-facial cleft who experienced ICR and to identify any possible aetiological factors.Materials and method A retrospective investigation of all oro-facial cleft patients treated at the Dublin Cleft Prosthodontic Department, St James's Hospital, Dublin...
May 12, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28486039/flow-cytometric-measurement-of-the-cellular-propagation-of-tdp-43-aggregation
#17
Rafaa Zeineddine, Daniel R Whiten, Natalie E Farrawell, Luke McAlary, Maya A Hanspal, Janet R Kumita, Mark R Wilson, Justin J Yerbury
Amyotrophic lateral sclerosis is a devastating neuromuscular degenerative disease characterized by a focal onset of motor neuron loss, followed by contiguous outward spreading of pathology including TAR DNA-binding protein of 43 kDa (TDP-43) aggregates. Previous work suggests that TDP-43 can move between cells. Here we used a novel flow cytometry technique (FloIT) to analyze TDP-43 inclusions and propagation. When cells were transfected to express either mutant G294A TDP-43 fused to GFP or wild type TDP-43fused to tomato red and then co-cultured, flow cytometry detected intact cells containing both fusion proteins and using FloIT detected an increase in the numbers of inclusions in lysates from cells expressing wild type TDP-43-tomato...
May 4, 2017: Prion
https://www.readbyqxmd.com/read/28469814/comparison-of-laser-and-power-bleaching-techniques-in-tooth-color-change
#18
Reza Fekrazad, Shervin Alimazandarani, Katayoun Am Kalhori, Hadi Assadian, Seyed-Mahdi Mirmohammadi
BACKGROUND: Laser-assisted bleaching uses laser beam to accelerate release of free radicals within the bleaching gel to decrease time of whitening procedure. The aim of this study was to compare the efficacy of power bleaching using Opalescence Xtra Boost® and laser bleaching technique using LaserSmile gel and diode laser as an activator in their tooth whitening capacity. MATERIAL AND METHODS: Student t test showed that the laser bleaching group significantly outperformed the power bleaching group in changing ∆E (p=0...
April 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28467302/single-protein-detection-in-crowded-molecular-environments-in-cryo-em-images
#19
J Peter Rickgauer, Nikolaus Grigorieff, Winfried Denk
We present an approach to study macromolecular assemblies by detecting component proteins' characteristic high-resolution projection patterns, calculated from their known 3D structures, in single electron cryo-micrographs. Our method detects single apoferritin molecules in vitreous ice with high specificity and determines their orientation and location precisely. Simulations show that high spatial-frequency information and-in the presence of protein background-a whitening filter are essential for optimal detection, in particular for images taken far from focus...
May 3, 2017: ELife
https://www.readbyqxmd.com/read/28426841/bilateral-retinal-whitening-in-a-hospitalized-patient
#20
Ferhina S Ali, Ehsan Rahimy
No abstract text is available yet for this article.
April 20, 2017: JAMA Ophthalmology
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