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Therapy of spinal cord injury

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https://www.readbyqxmd.com/read/28723746/effects-of-hyperbaric-oxygen-therapy-on-depression-and-anxiety-in-the-patients-with-incomplete-spinal-cord-injury-a-strobe-compliant-article
#1
Juan-Juan Feng, You-Hui Li
Little research has been done on the effects of hyperbaric oxygen (HBO) on depression and anxiety after spinal cord injury (SCI). The aim of this study was to investigate the effects of HBO on psychological problems and never function, especially on depression and anxiety in the patients with incomplete SCI (ISCI).Sixty patients with ISCI combined with depression and anxiety were randomly divided into HBO group (20 cases), psychotherapy group (20 cases), and conventional rehabilitation control group (20 cases)...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28720322/rodent-large-animal-and-non-human-primate-models-of-spinal-cord-injury
#2
REVIEW
Raffaele Nardone, Cristina Florea, Yvonne Höller, Francesco Brigo, Viviana Versace, Piergiorgio Lochner, Stefan Golaszewski, Eugen Trinka
In this narrative review we aimed to assess the usefulness of the different animal models in identifying injury mechanisms and developing therapies for humans suffering from spinal cord injury (SCI). Results obtained from rodent studies are useful but, due to the anatomical, molecular and functional differences, confirmation of these findings in large animals or non-human primates may lead to basic discoveries that cannot be made in rodent models and that are more useful for developing treatment strategies in humans...
June 21, 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/28716393/combine-effect-of-chondroitinase-abc-and-low-level-laser-660nm-on-spinal-cord-injury-model-in-adult-male-rats
#3
Atousa Janzadeh, Arash Sarveazad, Mahmoud Yousefifard, Sima Dameni, Fazel Sahraneshin Samani, Kobra Mokhtarian, Farinaz Nasirinezhad
After spinal cord injury (SCI) there are many recoveries inhibiting factors such as chondroitin sulfate proteoglycan (CSPG) and inflammation. The present study investigated the combinational effect of low level laser therapy (LLLT) as anti-inflammatory agent and Chondroitinase ABC (ChABC) enzyme as CSPG digesting factor on spinal cord after injury. This study performed on 44 male Wistar rats, spinal cord injury induced by a clip compression injury. Animals received two-weeks treatment of 660nm low level laser (LLL) and intraspinal injection of 1μg ChABC...
July 14, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28716325/peripheral-and-sacral-neuromodulation-in-the-treatment-of-neurogenic-lower-urinary-tract-dysfunction
#4
REVIEW
Paholo G Barboglio Romo, Priyanka Gupta
Sacral and peripheral neuromodulation are minimally invasive surgical procedures that are third-line therapy options for the treatment of patients with idiopathic overactive bladder syndrome. There has been interest in their efficacy in the management of neurogenic lower urinary tract dysfunction (NLUTD). Contemporary data suggest promising outcomes for urinary and bowel symptoms in carefully selected patients with spinal cord injury and/or multiple sclerosis. This article reviews the current literature regarding urinary and bowel outcomes in patients with NLUTD and also discusses contemporary studies that suggest that treatment during particular stages of neurologic injury may prevent long-term urinary sequelae...
August 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/28715613/isolation-and-characterization-of-canine-placenta-derived-mesenchymal-stromal-cells-for-the-treatment-of-neurological-disorders-in-dogs
#5
Connor Long, Lee Lankford, Priyadarsini Kumar, Robert Grahn, Dori L Borjesson, Diana Farmer, Aijun Wang
Spinal cord injury (SCI) is a devastating disorder that affects humans and dogs. The prognosis of SCI depends on the severity of the injury and can include varying levels of motor and sensory deficits including devastating paraplegia and quadriplegia. Placental mesenchymal stromal cells (PMSCs) have been shown to improve wound healing and possess neuroprotective and immunomodulatory capabilities, but have not yet been clinically tested for the treatment of SCI. This study established a protocol to isolate fetal PMSCs from canine placentas and characterized their paracrine secretion profile and ability to stimulate neurons in vitro to assess their potential as a treatment option for neurological disorders in dogs...
July 17, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28714852/the-small-molecule-mimetic-agonist-trimebutine-of-adhesion-molecule-l1-contributes-to-functional-recovery-after-spinal-cord-injury-in-mice
#6
Junping Xu, Chengliang Hu, Qiong Jiang, Hongchao Pan, Huifan Shen, Melitta Schachner
Curing spinal cord injury (SCI) in mammals is a daunting task because of the lack of permissive mechanisms and strong inhibitory responses at and around the lesion. The neural cell adhesion molecule L1CAM (L1) has been shown to favor axonal regrowth and enhance neuronal survival and synaptic plasticity, and thus constitutes a viable target to promote regeneration after SCI. Since delivery of full-length L1 or its extracellular domain could encounter difficulties in translation to therapy in humans, we have identified several small organic compounds that bind to L1 and stimulate neuronal survival, neuronal migration, and neurite outgrowth in an L1-dependent manner...
July 14, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28712735/spontaneous-regression-of-post-traumatic-syringomyelia-a-case-report-and-literature-review
#7
Monish M Maharaj, Kevin Phan, Ralph Mobbs
Syringomyelia defines a condition in which myelopathy develops secondary to the formation of a cyst or cavity within the spinal cord parenchyma known as a syrinx. Although there is a significant volume of studies analysing the underlying mechanisms behind their formation, the management of such cavities remains an ongoing topic of debate. Aside from conservative approach, a range of surgical options exist, however long term outcomes are poor and a literature search reveals that the overall benefits are questionable...
July 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28701922/bone-marrow-mesenchymal-stem-cell-transplantation-promotes-functional-improvement-associated-with-cntf-stat3-activation-after-hemi-sectioned-spinal-cord-injury-in-tree-shrews
#8
Liu-Lin Xiong, Fei Liu, Bing-Tuan Lu, Wen-Ling Zhao, Xiu-Juan Dong, Jia Liu, Rong-Ping Zhang, Piao Zhang, Ting-Hua Wang
Hemi-sectioned spinal cord injury (hSCI) can lead to spastic paralysis on the injured side, as well as flaccid paralysis on the contralateral side, which can negatively affect a patient's daily life. Stem-cell therapy may offer an effective treatment option for individuals with hSCI. To examine the role of bone marrow mesenchymal stem cells (BMSCs) transplantation on hSCI and explore related mechanisms in the tree shrews, here, we created a model of hSCI by inducing injury at the tenth thoracic vertebra (T10)...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28691015/-mtor-signaling-pathway-a-potential-target-of-curcumin-in-the-treatment-of-spinal-cord-injury
#9
REVIEW
Jingquan Lin, Xue Huo, Xuehong Liu
The purpose of this review is to discuss the possibility of the treatment of spinal cord injury (SCI) with curcumin via regulating the mTOR signaling pathway, which may provide another strong support for curcumin to be a promising medicine applied to the treatment of SCI. Curcumin is termed as a multifunctional targeting therapy drug that regulates the mTOR signaling pathway in the treatment of numerous diseases. Previous research has already revealed that mTOR signaling pathway plays a vital role in prognosis, which involves the axon regeneration and autophagy...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28689389/is-there-additive-therapeutic-effect-when-gcsf-combined-with-adipose-derived-stem-cell-in-a-rat-model-of-acute-spinal-cord-injury
#10
Joongkee Min, Jeong Hoon Kim, Kyoung Hyo Choi, Hyung Ho Yoon, Sang Ryong Jeon
OBJECTIVE: Functional and neural tissue recovery has been reported in many animal studies conducted with stem cells. However, the combined effect of cytokines and stem cells has not yet been adequately researched. Here, we analyzed the additive effects of granulocyte colony-stimulating factor (GCSF) on adipose-derived stem cells (ADSCs) infusion in the treatment of acute spinal cord injury (SCI) in rats. METHODS: Four days after intrathecal infusion tubes implantation in Sprague-Dawley rats, SCI was induced with an infinite horizon impactor...
July 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28687659/neutrophils-induce-astroglial-differentiation-and-migration-of-human-neural-stem-cells-via-c1q-and-c3a-synthesis
#11
Mitra J Hooshmand, Hal X Nguyen, Katja M Piltti, Francisca Benavente, Samuel Hong, Lisa Flanagan, Nobuko Uchida, Brian J Cummings, Aileen J Anderson
Inflammatory processes play a key role in pathophysiology of many neurologic diseases/trauma, but the effect of immune cells and factors on neurotransplantation strategies remains unclear. We hypothesized that cellular and humoral components of innate immunity alter fate and migration of human neural stem cells (hNSC). In these experiments, conditioned media collected from polymorphonuclear leukocytes (PMN) selectively increased hNSC astrogliogenesis and promoted cell migration in vitro. PMN were shown to generate C1q and C3a; exposure of hNSC to PMN-synthesized concentrations of these complement proteins promoted astrogliogenesis and cell migration...
July 7, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28684744/learning-new-movements-after-paralysis-results-from-a-home-based-study
#12
Camilla Pierella, Farnaz Abdollahi, Elias Thorp, Ali Farshchiansadegh, Jessica Pedersen, Ismael Seáñez-González, Ferdinando A Mussa-Ivaldi, Maura Casadio
Body-machine interfaces (BMIs) decode upper-body motion for operating devices, such as computers and wheelchairs. We developed a low-cost portable BMI for survivors of cervical spinal cord injury and investigated it as a means to support personalized assistance and therapy within the home environment. Depending on the specific impairment of each participant, we modified the interface gains to restore a higher level of upper body mobility. The use of the BMI over one month led to increased range of motion and force at the shoulders in chronic survivors...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28673596/intra-spinal-microstimulation-may-alleviate-chronic-pain-after-spinal-cord-injury
#13
Bin Shu, Fei Yang, Yun Guan
Chronic pain after spinal cord injury (SCI) is a form of central neuropathic pain that is debilitating and often refractory to current pharmacological treatments. Neurostimulation pain therapies, such as epidural spinal cord stimulation, have only moderate success in reducing SCI pain. The pathogenesis of SCI pain may involve a state of central neuronal hyperexcitability, especially in the spinal cord dorsal horn, that develops after injury. We hypothesize that the neuronal structures near the spinal cord injury site may be an important pain generator, and intraspinal microstimulation (ISMS) may normalize dorsal horn neuronal hyperexcitability and hence alleviate SCI pain...
July 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28670409/traumatic-spinal-cord-injury-long-term-motor-sensory-and-urinary-outcomes
#14
Rouzbeh Motiei-Langroudi, Homa Sadeghian
STUDY DESIGN: Retrospective study. PURPOSE: To evaluate how motor, sensory, and urinary outcomes of spinal cord injury (SCI) patients were influenced in the long term. OVERVIEW OF LITERATURE: SCI is a potentially disabling and devastating neurological outcome that can occur because of spinal column fractures. Most studies have not evaluated or have failed to show the influence of different surgical approaches and other parameters on neurological recovery...
June 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28665182/systemic-administration-of-exosomes-released-from-mesenchymal-stromal-cells-attenuates-apoptosis-inflammation-and-promotes-angiogenesis-after-contusion-spinal-cord-injury-in-rats
#15
Jiang-Hu Huang, Xiao-Ming Yin, Yang Xu, Chun-Cai Xu, Xi Lin, Fu-Biao Ye, Yong Cao, Fei-Yue Lin
Spinal cord injury (SCI) is one of the most common devastating injuries, which causes permanent disabilities such as paralysis and loss of movement or sensation. The precise pathogenic mechanisms of the disease remain unclear, and as of yet, there is no effective cure. Mesenchymal stem cells (MSCs) show promise as an effective therapy in the experimental models of SCI. MSCs secrete various factors which can modulate a hostile environment, which is called the paracrine effect. Among these paracrine molecules, exosome is considered to be the most valuable therapeutic factor...
June 30, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28661400/cortex-dependent-recovery-of-unassisted-hindlimb-locomotion-after-complete-spinal-cord-injury-in-adult-rats
#16
Anitha Manohar, Guglielmo Foffani, Patrick D Ganzer, John R Bethea, Karen A Moxon
After paralyzing spinal cord injury the adult nervous system has little ability to 'heal' spinal connections, and it is assumed to be unable to develop extra-spinal recovery strategies to bypass the lesion. We challenge this assumption, showing that completely spinalized adult rats can recover unassisted hindlimb weight support and locomotion without explicit spinal transmission of motor commands through the lesion. This is achieved with combinations of pharmacological and physical therapies that maximize cortical reorganization, inducing an expansion of trunk motor cortex and forepaw sensory cortex into the deafferented hindlimb cortex, associated with sprouting of corticospinal axons...
June 29, 2017: ELife
https://www.readbyqxmd.com/read/28659784/effects-of-assist-as-needed-upper-extremity-robotic-therapy-after-incomplete-spinal-cord-injury-a-parallel-group-controlled-trial
#17
John Michael Frullo, Jared Elinger, Ali Utku Pehlivan, Kyle Fitle, Kathryn Nedley, Gerard E Francisco, Fabrizio Sergi, Marcia K O'Malley
BACKGROUND: Robotic rehabilitation of the upper limb following neurological injury has been supported through several large clinical studies for individuals with chronic stroke. The application of robotic rehabilitation to the treatment of other neurological injuries is less developed, despite indications that strategies successful for restoration of motor capability following stroke may benefit individuals with incomplete spinal cord injury (SCI) as well. Although recent studies suggest that robot-aided rehabilitation might be beneficial after incomplete SCI, it is still unclear what type of robot-aided intervention contributes to motor recovery...
2017: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/28658409/traumatic-spinal-cord-injury-current-concepts-and-treatment-update
#18
Carolina Rouanet, Danyelle Reges, Eva Rocha, Vivian Gagliardi, Gisele Sampaio Silva
Spinal cord injury (SCI) affects 1.3 million North Americans, with more than half occurring after trauma. In Brazil, few studies have evaluated the epidemiology of SCI with an estimated incidence of 16 to 26 per million per year. The final extent of the spinal cord damage results from primary and secondary mechanisms that start at the moment of the injury and go on for days, and even weeks, after the event. There is convincing evidence that hypotension contributes to secondary injury after acute SCI. Surgical decompression aims at relieving mechanical pressure on the microvascular circulation, therefore reducing hypoxia and ischemia...
June 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28658125/anterior-cervical-distraction-and-screw-elevating-pulling-reduction-for-traumatic-cervical-spine-fractures-and-dislocations-a-retrospective-analysis-of-86-cases
#19
Haoxi Li, Zhiyao Yong, Zhaoxiong Chen, Yufeng Huang, Zhoudan Lin, Desheng Wu
Treatment of cervical fracture and dislocation by improving the anterior cervical technique.Anterior cervical approach has been extensively used in treating cervical spine fractures and dislocations. However, when this approach is used in the treatment of locked facet joints, an unsatisfactory intraoperative reduction and prying reduction increases the risk of secondary spinal cord injury. Thus, herein, the cervical anterior approach was improved. With distractor and screw elevation therapy during surgery, the restoration rate is increased, and secondary injury to the spinal cord is avoided...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28654477/use-of-lower-limb-robotics-to-enhance-practice-and-participation-in-individuals-with-neurological-conditions
#20
Arun Jayaraman, Sheila Burt, William Zev Rymer
PURPOSE: To review lower-limb technology currently available for people with neurological disorders, such as spinal cord injury, stroke, or other conditions. We focus on 3 emerging technologies: treadmill-based training devices, exoskeletons, and other wearable robots. SUMMARY OF KEY POINTS: Efficacy for these devices remains unclear, although preliminary data indicate that specific patient populations may benefit from robotic training used with more traditional physical therapy...
July 2017: Pediatric Physical Therapy
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