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Therapy of spinal cord injury

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https://www.readbyqxmd.com/read/29339580/advantages-of-soft-subdural-implants-for-the-delivery-of-electrochemical-neuromodulation-therapies-to-the-spinal-cord
#1
Marco Capogrosso, Jérôme Gandar, Nathan Greiner, Eduardo Martin Moraud, Nikolaus Wenger, Polina Shkorbatova, Pavel E Мusienko, Ivan Minev, Stephanie P Lacour, Gregoire Courtine
We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or above the dura mater. Theoretically, the subdural location combines many advantages, including increased selectivity of electrical stimulation, lower stimulation thresholds, and targeted chemical stimulation through local drug delivery. However, these advantages have not been documented, nor have their functional impact been studied in-silico or in a relevant animal model of neurological disorders using a multimodal neural interface...
January 17, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29337123/mesenchymal-stem-cell-based-therapy-improves-lower-limb-movement-after-spinal-cord-ischemia-in-rats
#2
Shinya Takahashi, Kei Nakagawa, Mayumi Tomiyasu, Ayumu Nakashima, Keijiro Katayama, Takeshi Imura, Bagus Herlambang, Fumie Okubo, Koji Arihiro, Yumi Kawahara, Louis Yuge, Taijiro Sueda
BACKGROUND: Spinal cord ischemia is a devastating complication following thoracic and thoracoabdominal aortic surgery. In this study, we aimed to investigate the effects of mesenchymal stem cells (MSCs), which have regenerative capability and exert paracrine actions on damaged tissues, injected into rat models of spinal cord ischemia-reperfusion injury. METHODS: Forty-five Sprague-Dawley rats were divided into sham, phosphate-buffered saline (PBS), and MSC groups...
January 11, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29336209/effects-of-treadmill-training-combined-with-serotonergic-interventions-on-spasticity-after-contusive-spinal-cord-injury
#3
Youngjae Ryu, Toru Ogata, Motoshi Nagao, Yasuhiro Sawada, Ryohei Nishimura, Naoki Fujita
Spasticity usually emerges during the course of recovery from spinal cord injury (SCI). While medications and physical rehabilitation are prescribed to alleviate spastic symptoms, the insufficiency of their effects remains an important problem to be addressed. Given the challenges associated with increasing the dose of medication, we supposed that a combination therapy with medication and physical rehabilitation can be effective. Therefore, we examined the effects of treadmill training (TMT) along with serotonergic medication using a spastic rat model after contusive injury...
January 16, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29335475/discontinuous-ventilator-weaning-of-patients-with-acute-sci
#4
Wout Füssenich, Sven Hirschfeld Araujo, Birgitt Kowald, Allard Hosman, Marc Auerswald, Roland Thietje
STUDY DESIGN: Retrospective, single centre cohort study. OBJECTIVES: To determine factors associated with ventilator weaning success and failure in patients with acute spinal cord injury (SCI); determine length of time and attempts required to wean from the ventilator successfully and determine the incidence of pneumonia. SETTING: BG Klinikum Hamburg, Level 1 trauma centre, SCI Department, Germany. METHODS: From 2010 until 2017, 165 consecutive patients with cervical SCI, initially dependent on a ventilator, were included and weaned discontinuously via tracheal cannula...
January 16, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29330870/cell-therapy-for-spinal-cord-injury-with-olfactory-ensheathing-glia-cells-oecs
#5
REVIEW
Rosa M Gómez, Magdy Y Sánchez, Maria Portela-Lomba, Kemel Ghotme, George E Barreto, Javier Sierra, M Teresa Moreno-Flores
The prospects of achieving regeneration in the central nervous system (CNS) have changed, as most recent findings indicate that several species, including humans, can produce neurons in adulthood. Studies targeting this property may be considered as potential therapeutic strategies to respond to injury or the effects of demyelinating diseases in the CNS. While CNS trauma may interrupt the axonal tracts that connect neurons with their targets, some neurons remain alive, as seen in optic nerve and spinal cord (SC) injuries (SCIs)...
January 13, 2018: Glia
https://www.readbyqxmd.com/read/29324409/assessment-of-spasticity-by-a-pendulum-test-in-sci-patients-who-exercise-fes-cycling-or-receive-only-conventional-therapy
#6
Lana Popovic-Maneski, Antonina Aleksic, Amine Metani, Vance Bergeron, Radoje Cobeljic, Dejan B Popovic
Increased muscle tone and exaggerated tendon reflexes characterize most of the individuals after a spinal cord injury (SCI). We estimated seven parameters from the pendulum test and used them to compare with the Ashworth modified scale of spasticity grades in three populations (retrospective study) to assess their spasticity. Three ASIA B SCI patients who exercised on a stationary FES bicycle formed group F, six ASIA B SCI patients who received only conventional therapy were in the group C, and six healthy individuals constituted the group H...
January 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29323194/human-mesenchymal-stromal-cell-derived-extracellular-vesicles-modify-microglial-response-and-improve-clinical-outcomes-in-experimental-spinal-cord-injury
#7
Katherine A Ruppert, Tin T Nguyen, Karthik S Prabhakara, Naama E Toledano Furman, Amit K Srivastava, Matthew T Harting, Charles S Cox, Scott D Olson
No current clinical intervention can alter the course of acute spinal cord injury (SCI), or appreciably improve neurological outcome. Mesenchymal stromal cells (MSCs) have been shown to modulate the injury sequelae of SCI largely via paracrine effects, although the mechanisms remain incompletely understood. One potential modality is through secretion of extracellular vesicles (EVs). In this study, we investigate whether systemic administration of EVs isolated from human MSCs (MSCEv) has the potential to be efficacious as an alternative to cell-based therapy for SCI...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29323028/surgical-reconstruction-of-spinal-cord-circuit-provides-functional-return-in-humans
#8
REVIEW
Thomas Carlstedt, Nicholas James, Mårten Risling
This mini review describes the current surgical strategy for restoring function after traumatic spinal nerve root avulsion in brachial or lumbosacral plexus injury in man. As this lesion is a spinal cord or central nervous injury functional return depends on spinal cord nerve cell growth within the central nervous system. Basic science, clinical research and human application has demonstrated good and useful motor function after ventral root avulsion followed by spinal cord reimplantation. Recently, sensory return could be demonstrated following spinal cord surgery bypassing the injured primary sensory neuron...
December 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29319731/comparison-among-bone-marrow-mesenchymal-stem-and-mononuclear-cells-to-promote-functional-recovery-after-spinal-cord-injury-in-rabbits
#9
Antônio Filipe Braga Fonseca, Jussara Peters Scheffer, Arthur Giraldi-Guimarães, Bárbara Paula Coelho, Raphael Mansur Medina, André Lacerda Abreu Oliveira
PURPOSE: To investigate the efficacy of allogeneic mesenchymal stem-cells and autologous mononuclear cells to promote sensorimotor recovery and tissue rescue. METHODS: Female rabbits were submitted to the epidural balloon inflation method and the intravenous cells administrations were made after 8 hours or seven days after injury induction. Sensorimotor evaluation of the hindlimbs was performed, and the euthanasia was made thirty days after the treatment. Spinal cords were stained with hematoxylin and eosin...
December 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29317311/concomitant-use-of-mesenchymal-stem-cells-and-neural-stem-cells-for-treatment-of-spinal-cord-injury-a-combo-cell-therapy-approach
#10
Seyed Mojtaba Hosseini, Mahsa Sani, Kh Husnanin Haider, Mohammadreza Dorvash, Seyyed Mohyeddin Ziaee, Aliasghar Karimi, Mohmmad Reza Namavar
with neural stem cells (NSCs) provides a hope to recover the neural damage and compensate for the lost neural structures for restoration of interrupted neural communications above and below the site of injury. However, cell-based therapy approach suffers from many biological barriers and technical caveats which severely hamper the prognosis. The biochemically-rich microenvironment at the site of spinal cord injury (SCI), the continuing neuro-degenerative process and infiltrating immune cells offer a serious barrier to the donor cells...
January 6, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29316845/rho-inhibitor-vx-210-in-acute-traumatic-subaxial-cervical-spinal-cord-injury-design-of-the-spinal-cord-injury-rho-inhibition-investigation-spring-clinical-trial
#11
Michael G Fehlings, Kee D Kim, Bizhan Aarabi, Marco Rizzo, Lisa M Bond, Lisa McKerracher, Alexander Vaccaro, David O Okonkwo
Traumatic spinal cord injury (SCI) is associated with a lifetime of disability stemming from loss of motor, sensory, and autonomic functions; these losses, along with increased comorbid sequelae, negatively impact health outcomes and quality of life. Early decompression surgery after SCI can enhance patient outcomes but does not directly facilitate neural repair and regeneration. Currently, there are no FDA-approved pharmacologic therapies to augment motor function and functional recovery in individuals with traumatic SCI...
January 9, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29315225/fm19g11-and-ependymal-progenitor-stem-cell-combinatory-treatment-enhances-neuronal-preservation-and-oligodendrogenesis-after-severe-spinal-cord-injury
#12
Ana Alastrue-Agudo, Francisco Javier Rodriguez-Jimenez, Eric López Mocholi, Francesca De Giorgio, Slaven Erceg, Victoria Moreno-Manzano
Spinal cord injury (SCI) suffers from a lack of effective therapeutic strategies. We have previously shown that individual therapeutic strategies, transplantation of ependymal stem/progenitor cells of the spinal cord after injury (epSPCi) or FM19G11 pharmacological treatment, induce moderate functional recovery after SCI. Here, the combination of treatments has been assayed for functional and histological analysis. Immediately after severe SCI, one million epSPCi were intramedullary injected, and the FM19G11 compound or dimethyl sulfoxide (DMSO) (as the vehicle control) was administrated via intrathecal catheterization...
January 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29307082/biomarkers-in-spinal-cord-injury-from-prognosis-to-treatment
#13
REVIEW
Leonardo Fonseca Rodrigues, Vivaldo Moura-Neto, Tania Cristina Leite de Sampaio E Spohr
Spinal cord injury (SCI) is considered an incurable condition, having a heterogenous recovery and uncertain prognosis. Therefore, a reliable prediction of the improvement in the acute phase could benefit patients. Physicians are unanimous in insisting that at the initial damage of the spinal cord (SC), the patient should be carefully evaluated in order to help selecting an appropriate neuroprotective treatment. However, currently, neurologic impairment after SCI is measured and classified by functional examination...
January 6, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29298725/sex-differences-in-primary-muscle-afferent-sensitization-following-ischemia-and-reperfusion-injury
#14
Jessica L Ross, Luis F Queme, Jordan E Lamb, Kathryn J Green, Michael P Jankowski
BACKGROUND: Chronic pain conditions are more prevalent in women, but most preclinical studies into mechanisms of pain generation are performed using male animals. Furthermore, whereas group III and IV nociceptive muscle afferents provoke central sensitization more effectively than their cutaneous counterparts, less is known about this critical population of muscle nociceptors. Here, we compare the physiology of individual muscle afferents in uninjured males and females. We then characterize the molecular, physiological, and behavioral effects of transient ischemia and reperfusion injury (I/R), a model we have extensively studied in males and in females...
January 3, 2018: Biology of Sex Differences
https://www.readbyqxmd.com/read/29298691/volition-adaptive-control-for-gait-training-using-wearable-exoskeleton-preliminary-tests-with-incomplete-spinal-cord-injury-individuals
#15
Vijaykumar Rajasekaran, Eduardo López-Larraz, Fernando Trincado-Alonso, Joan Aranda, Luis Montesano, Antonio J Del-Ama, Jose L Pons
BACKGROUND: Gait training for individuals with neurological disorders is challenging in providing the suitable assistance and more adaptive behaviour towards user needs. The user specific adaptation can be defined based on the user interaction with the orthosis and by monitoring the user intentions. In this paper, an adaptive control model, commanded by the user intention, is evaluated using a lower limb exoskeleton with incomplete spinal cord injury individuals (SCI). METHODS: A user intention based adaptive control model has been developed and evaluated with 4 incomplete SCI individuals across 3 sessions of training per individual...
January 3, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29285998/structure-function-evaluation-of-stem-cell-therapies-for-spinal-cord-injury
#16
Fuguo Zhang
Spinal cord injuries (SCI) are prevalent, devastating for quality and expectancy of life, and causing heavy economic burdens. Stem cell therapies hold promise in complete structural and functional restoration of SCI. Various kinds of stem cells involving embryonic stem cells (ESCs), bone marrow stromal cells (BMSCs), neural stem cells (NSCs) and induced pluripotent stem cells (iPSCs), are extensively used in regenerative research of SCI. For evaluation, the survival and integration of transplanted cells, spinal cord reconstruction and functional recovery, should all be considered...
December 29, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29285620/effect-of-the-combined-treatment-of-albumin-with-plasma-synthesised-pyrrole-polymers-on-motor-recovery-after-traumatic-spinal-cord-injury-in-rats
#17
Omar Fabela-Sánchez, Hermelinda Salgado-Ceballos, Luis Medina-Torres, Laura Álvarez-Mejía, Stephany Sánchez-Torres, Rodrigo Mondragón-Lozano, Axayácatl Morales-Guadarrama, Araceli Díaz-Ruiz, María-Guadalupe Olayo, Guillermo J Cruz, Juan Morales, Camilo Ríos, Roberto Olayo
Traumatic spinal cord injury (TSCI) is a health problem for which there is currently no treatment or definitive therapy. Medicine has explored therapeutic options for patients with TSCI with the aim to improve their quality of life. One alternative has been the development of biomaterials that offer neuroprotection or neuroregeneration of damaged nerve tissue. The microinjection of iodine-doped polypyrrole particles synthesised by plasma (PPPy/I) has shown neuroprotective effects that favour motor function recovery in experimental animals with TSCI...
December 28, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29279800/closed-therapy-of-thoracic-and-lumbar-vertebral-body-fractures-in-trauma-patients
#18
Jarvis W Walters, Tammy R Kopelman, Arpan A Patel, Patrick J O'Neill, Poya Hedayati, Paola G Pieri, Sydney J Vail, Salvatore C Lettieri, Iman Feiz-Erfan
Background: The failure rate for the closed/non-surgical treatment of thoracic and lumbar vertebral body fractures (TLVBF) in trauma patients has not been adequately evaluated utilizing computed tomography (CT) studies. Methods: From 2007 to 2008, consecutive trauma patients, who met inclusion criteria, with a CT diagnosis of acute TLVBF undergoing closed treatment were assessed. The failure rates for closed therapy, at 3 months post-trauma, were defined by progressive deformity, vertebral body collapse, or symptomatic/asymptomatic pseudarthrosis...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29279745/effects-of-atorvastatin-in-patients-with-acute-spinal-cord-injury
#19
Javad Aghazadeh, Parviz Samadi Motlagh, Firooz Salehpour, Ali Meshkini, Majid Fatehi, Farhad Mirzaei, Seyed Ahmad Naseri Alavi
Study Design: Clinical trial study. Purpose: The aim of this study was to evaluate the effect of atorvastatin on sensory and motor function in patients with acute spinal cord injury. Overview of Literature: The prevalence and incidence of traumatic spinal cord injury are increasing. Statins are well established for use in hypercholesterolemia as well as during anti-inflammatory events. Methods: This clinical trial study included 60 patients with acute spinal cord injury...
December 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/29276474/experimental-gene-therapy-with-serine-histogranin-and-endomorphin-1-for-the-treatment-of-chronic-neuropathic-pain
#20
Stanislava Jergova, Catherine E Gordon, Shyam Gajavelli, Jacqueline Sagen
The insufficient pain relief provided by current pharmacotherapy for chronic neuropathic pain is a serious medical problem. The enhanced glutamate signaling via NMDA receptors appears to be one of the key events in the development of chronic pain. Although effective, clinical use of systemic NMDA antagonists is limited by adverse effects such as hallucinations and motor dysfunction. Opioids are also potent analgesics but their chronic use is accompanied by tolerance and risk of addiction. However, combination of NMDA antagonists and opioids seems to provide a stable pain relieve at subthreshold doses of both substances, eliminating development of side effects...
2017: Frontiers in Molecular Neuroscience
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