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https://www.readbyqxmd.com/read/28643929/in-silico-and-functional-evaluation-of-pth1r-mutations-found-in-patients-with-primary-failure-of-eruption-pfe
#1
H M Hendricks, S Bencharit, W Seaman, S A Frazier-Bowers
OBJECTIVES: The genetic basis of PFE (OMIM ID: 125350) was interrogated using molecular functional studies. PFE is a disorder that results in a poor prognosis in the eruption of teeth and by extension, in treatment with a continuous archwire. We tested the hypothesis that PTH1R mutations result in loss of function due to altered protein structure to determine (i) the fate of a functional PTH1R mutation and (ii) the resulting PTH1R protein structure of each functional mutation. METHODS: We used immunofluorescence assay of COS7 cells that were transfected with either the WT or 1092delG PTH1R mutation sequence to compare the fate of the expressed protein...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28642551/aesthetic-preformed-crowns-for-primary-teeth
#2
Greig D Taylor
Data sourcesMedline, Cochrane central register of controlled trials, US National Institutes of Health Trials Register and the World Health Organization International Clinical Trials Registry Platform.Study selectionEnglish language randomised clinical trials comparing APCs with conventional restorative techniques for primary teeth.Data extraction and synthesisStudy selection and data abstraction were conducted independently by two reviewers. Risk of bias was assessed using the Cochrane risk of bias tool. Study characteristics and results were described qualitatively...
June 23, 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28631087/molar-incisor-hypomineralization-proportion-and-severity-in-primary-public-school-children-in-graz-austria
#3
Barbara Buchgraber, Lumnije Kqiku, Kurt A Ebeleseder
OBJECTIVE: The aim of this study was to determine the proportion and severity of molar incisor hypomineralization (MIH) in primary school children in Graz (southeast of Austria). MATERIALS AND METHODS: In 1111 children aged 6 to 12 years (mean age 9.0 ± 1.2), a wet examination of all teeth was performed by three trained examiners using a dental chair, optimal illumination, a dental mirror, and a dental explorer. All teeth with MIH lesions were registered so that different definitions of MIH were applicable...
June 19, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28628822/spatial-distribution-of-trace-element-ca-normalized-ratios-in-primary-and-permanent-human-tooth-enamel
#4
Théo Tacail, Lenka Kovačiková, Jaroslav Brůžek, Vincent Balter
The trace elements distribution embedded in tooth enamel offers a means to study exposure of toxic metals and allows the reconstruction of dietary behaviors. The quantification of most of the elements with a spatial high resolution (~50μm) is routinely achieved using laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS). However, the lack of a comprehensive framework of trace elements distribution in enamel jeopardizes any endorsed sampling strategy using LA-ICPMS. The present work is an effort to improve our knowledge on this issue...
June 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28627737/caries-treatment-decisions-among-undergraduate-and-postgraduate-students-supported-by-visual-detection-systems
#5
Vinícius Krieger Costa Nogueira, Diego Girotto Bussaneli, Manuel Restrepo Restrepo, Rubens Spin-Neto, Lourdes Aparecida Martins Dos Santos-Pinto, Thalita Boldieri, Rita de Cássia Loiola Cordeiro
BACKGROUND: The difficulties of caries diagnosis and the level of examiner's experience may influence the treatment decision, resulting excessive and inefficient intervention. AIM: This randomized experimental study evaluated caries treatment decisions made by undergraduate (UG) and postgraduate (PG) students when examination was performed through conventional visual clinical examination (CVCE) and when supported by ICDAS (IC) or Nyvad's (NY) criteria. DESIGN: Four UG and four PG initially analyzed, by CVCE, 300 primary incisors and molars surfaces of 25 children aged 5-12 years, and choose between no treatment, non-operative, and operative treatment...
June 19, 2017: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/28620641/a-rare-condition-of-bimaxillary-primary-molar-taurodontism
#6
Avula Jogendra Sai Sankar, Enuganti Sreedevi, Akkala Satya Gopal, Manne Naga Lakshmi
Taurodontism is a relatively rare variance with a very low incidence in primary dentition and only a few cases have been reported in the literature. It stands a challenge when these teeth require pulp therapy. This case report illustrates the oral rehabilitation of multiple primary molars with taurodontism involving both the maxillary and mandibular arches, which is a rare occurrence.
June 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28620634/dental-caries-and-associated-factors-in-children-aged-2-4-years-old-in-mbeya-city-tanzania
#7
Hery Mwakayoka, Joyce Rose Masalu, Emil Namakuka Kikwilu
STATEMENT OF THE PROBLEM: Dental caries in infants and young children is prevalent worldwide; its magnitude and associated factors vary between communities because of cultural and social economic differences. No such information was available for pre-school children in Mbeya city. PURPOSE: To determine dental caries status and associated factors in 2 to 4-year-old children in Mbeya city. MATERIALS AND METHOD: A cross sectional study was conducted among 525 children aged 2-4 years and their parents/caregivers...
June 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28620553/unusual-case-of-extraction-of-maxillary-lateral-incisors-and-mandibular-central-incisors
#8
Rosa-María Yañez-Vico, Maria Cadenas de Llano-Perula, Enrique Solano-Reina
INTRODUCTION: This article's purpose is to report a case where maxillary lateral incisors and mandibular central incisors are extracted and a canine substitution was performed as the best therapeutic option in order to obtain symmetry in a malocclusion with an upper lateral incisor with poor prognostic, solve moderate crowding, get enough space for the permanent dentition, and provide stability to the results. CASE REPORT: An 11-year-old boy with straight profile with acute-to-normal nasolabial angle and protruded lips, mixed dentition, lower and upper severe crowding, and a bilateral molar angle Class I...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28619207/trends-in-dental-caries-in-children-and-adolescents-according-to-poverty-status-in-the-united-states-from-1999-through-2004-and-from-2011-through-2014
#9
Bruce A Dye, Gabriela Lopez Mitnik, Timothy J Iafolla, Clemencia M Vargas
BACKGROUND: Except for a small increase in caries prevalence in young children from 1999 through 2004, the prevalence of pediatric caries in the United States has remained consistent for the past 3 decades. METHODS: The authors used data from the National Health and Nutrition Examination Survey (NHANES) (from 1999 through 2004 and from 2011 through 2014) to ascertain changes in caries prevalence in youth aged 2 to 19 years. The authors evaluated changes in the prevalence of caries experience, untreated caries, and severe caries (3 or more teeth with untreated caries) in the primary, mixed, and permanent dentition according to poverty status...
June 13, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28617400/-teeth-wedge-shaped-defects-in-adults-of-different-age-groups-remark-to-prevention-and-treatment
#10
A K Iordanishvili, O L Pikhur, D A Cherni
The aim of the study was to assess the treatment of teeth wedge defects in different age groups. Records of 383 patients (125 males and 258 females aged 22-85 years) treated in outpatient dental facilities with different ownership forms. It is shown that the medical care of patients with wedge-shaped teeth defects routinely consists of remineralization therapy and restoration of anatomical teeth shape regardless of the form of ownership. The extensiveness of dental rehabilitation as well as the use of more modern technologies are typical for private clinics and 96-100% of patients finished their treatment there...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28615507/genetic-evaluations-of-chinese-patients-with-odontohypophosphatasia-resulting-from-heterozygosity-for-mutations-in-the-tissue-non-specific-alkaline-phosphatase-gene
#11
Jia Wan, Li Zhang, Tang Liu, Yewei Wang
BACKGROUND: Hypophosphatasia is a rare heritable metabolic disorder characterized by defective bone and tooth mineralization accompanied by a deficiency of tissue-non-specific (liver/bone/kidney) isoenzyme of alkaline phosphatase activity, caused by a number of loss-of-function mutations in the alkaline phosphatase liver type gene. We seek to explore the clinical manifestations and identify the mutations associated with the disease in a Chinese odonto- hypophosphatasia family. RESULTS: The proband and his younger brother affected with premature loss of primary teeth at their 2-year-old...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28614533/effect-of-fluoride-on-salivary-immunoglobulins-and-sialic-acid
#12
Kadriye Görkem Ulu Güzel, Zuhal Kirzioğlu, Ali Kudret Adiloğlu, Münciye Semra Özay Ertürk
Objective: The aim of our study was to evaluate the effect of fluoride on salivary immunoglobulin and sialic acid levels in children with dental fluorosis and healthy teeth who live in places with high fluoride concentration in drinking water. Method: Fifty-one (51) healthy children between 6 and 12 years old with no caries were randomly selected from primary schools enrolled in the dental-care program operated by the Department of Pediatric Dentistry. The children were divided into two groups: group I comprised 26 children with dental fluorosis [Thylstrup-Fejerskov Dental Fluorosis Index (TFI) = 4] who lived in Isparta (2...
April 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28613154/seal-or-varnish-a-randomised-controlled-trial-to-determine-the-relative-cost-and-effectiveness-of-pit-and-fissure-sealant-and-fluoride-varnish-in-preventing-dental-decay
#13
Ivor Gordon Chestnutt, Simon Hutchings, Rebecca Playle, Sarah Morgan-Trimmer, Deborah Fitzsimmons, Nadine Aawar, Lianna Angel, Sharron Derrick, Cheney Drew, Ceri Hoddell, Kerenza Hood, Ioan Humphreys, Nigel Kirby, Tin Man Mandy Lau, Catherine Lisles, Maria Zeta Morgan, Simon Murphy, Jacqueline Nuttall, Kateryna Onishchenko, Ceri Phillips, Timothy Pickles, Charlotte Scoble, Julia Townson, Beverley Withers, Barbara Lesley Chadwick
BACKGROUND: Fissure sealant (FS) and fluoride varnish (FV) have been shown to be effective in preventing dental caries when tested against a no-treatment control. However, the relative clinical effectiveness and cost-effectiveness of these interventions is unknown. OBJECTIVE: To compare the clinical effectiveness and cost-effectiveness of FS and FV in preventing dental caries in first permanent molars (FPMs) in 6- and 7-year-olds and to determine their acceptability...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28611678/a-fourth-klk4-mutation-is-associated-with-enamel-hypomineralisation-and-structural-abnormalities
#14
Claire E L Smith, Jennifer Kirkham, Peter F Day, Francesca Soldani, Esther J McDerra, James A Poulter, Christopher F Inglehearn, Alan J Mighell, Steven J Brookes
"Amelogenesis imperfecta" (AI) describes a group of genetic conditions that result in defects in tooth enamel formation. Mutations in many genes are known to cause AI, including the gene encoding the serine protease, kallikrein related peptidase 4 (KLK4), expressed during the maturation stage of amelogenesis. In this study we report the fourth KLK4 mutation to be identified in autosomal recessively-inherited hypomaturation type AI, c.632delT, p.(L211Rfs(*)37) (NM_004917.4, NP_004908.4). This homozygous variant was identified in five Pakistani AI families and is predicted to result in a transcript with a premature stop codon that escapes nonsense mediated decay...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28611067/maximising-paediatricians-roles-in-improving-children-s-oral-health-lessons-from-leicester
#15
REVIEW
Jasmine Murphy, Rod Moore
AIMS: To provide an overview of steps taken to improve oral health in one UK city and to review factors relevant to maximising the contribution that paediatricians (and potentially other health professionals) can make to improving oral health. METHODS: The article provides information on the strategic approach taken in Leicester, one of the most ethnically diverse cities in England, and also one of the most deprived. Over a third of children aged 3 years, and half of those aged 5 years, have experience of obvious dental decay...
June 13, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28605602/role-of-primary-cilia-in-odontogenesis
#16
M Hampl, P Cela, H L Szabo-Rogers, M Kunova Bosakova, H Dosedelova, P Krejci, M Buchtova
Primary cilium is a solitary organelle that emanates from the surface of most postmitotic mammalian cells and serves as a sensory organelle, transmitting the mechanical and chemical cues to the cell. Primary cilia are key coordinators of various signaling pathways during development and maintenance of tissue homeostasis. The emerging evidence implicates primary cilia function in tooth development. Primary cilia are located in the dental epithelium and mesenchyme at early stages of tooth development and later during cell differentiation and production of hard tissues...
June 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28603707/maxillary-resection-for-cancer-zygomatic-implants-insertion-and-palatal-repair-as-single-stage-procedure-report-of-three-cases
#17
Pietro Salvatori, Antonio Mincione, Lucio Rizzi, Fabrizio Costantini, Alessandro Bianchi, Emma Grecchi, Umberto Garagiola, Francesco Grecchi
BACKGROUND: Oronasal/antral communication, loss of teeth and/or tooth-supporting bone, and facial contour deformity may occur as a consequence of maxillectomy for cancer. As a result, speaking, chewing, swallowing, and appearance are variably affected. The restoration is focused on rebuilding the oronasal wall, using either flaps (local or free) for primary closure, either prosthetic obturator. Postoperative radiotherapy surely postpones every dental procedure aimed to set fixed devices, often makes it difficult and risky, even unfeasible...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28598190/paediatric-laser-dentistry-part-2-hard-tissue-laser-applications
#18
G Olivi, C Caprioglio, M Olivi, M D Genovese
Erbium lasers can provide effective and minimally invasive caries removal in children. The bonding phase remains a critic step as well as the choice of material. Glass ionomers exhibits lower bonding properties in laser irradiated teeth compared to the conventional method or to composite and resin modified glass ionomer. Laser can also provide effective decontamination and coagulation effects in vital and non vital pulp therapy of primary teeth, improving and simplifying the cleaning and disinfecting steps.
June 2017: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28598187/dental-intrinsic-green-pigmentation-from-primary-to-mixed-dentition-clinical-and-histological-findings
#19
K Seremidi, K Kavvadia, K Tosios, A Pandi-Tsami
AIM: The aim of this report is to present a case of a child with green pigmentation of the primary dentition caused by bilirubin elevation due to choleostasis during neonatal life, and the 5-year follow-up. CASE REPORT: The case presented initially with bands of green pigmentation of all primary teeth in a pattern that followed the time of their calcification, with those formed earlier being more severely affected. Fading of the green pigmentation was detected during the follow-up, while erupted lower permanent incisors were normal...
June 2017: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28598181/a-new-method-for-deep-caries-treatment-in-primary-teeth-using-ozone-a-retrospective-study
#20
M Beretta, F Federici Canova
AIM: The aim of this study was to assess the effectiveness of a new protocol for deep caries treatment in deciduous teeth based on: 1) the incomplete removal of carious dentin tissue; 2) the use of new technology (ozone) for the disinfection of carious dentine; 3) the creation of a peripheral seal in healthy tissue for bonding procedures with rubber dam isolation. MATERIALS AND METHODS: From a personal database, authors selected 50 consecutive patients (28 males, 22 females; mean age 5...
June 2017: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
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