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https://www.readbyqxmd.com/read/29034853/floricoccus-tropicus-gen-nov-sp-nov-and-floricoccus-penangensis-sp-nov-isolated-from-fresh-flowers-of-durian-tree-and-hibiscus
#1
Li-Oon Chuah, Kien-Pong Yap, Ahamed Kamal Shamila-Syuhada, Kwai Lin Thong, Rosma Ahmad, Min Tze Liong, Gulam Rusul
Three strains of Gram-staining-positive, coccus-shaped, lactic acid bacteria, designated as HibF3(T), HibF2 and HibF5 were isolated from fresh flowers of hibiscus, and a fourth, DF1(T), was isolated from fresh flowers of durian tree, in Penang, Malaysia. Taxonomic characterisation was performed by polyphasic analysis. Sequence similarities of the 16S rRNA gene and the housekeeping rpoA and pheS genes of these strains with their closely-related lactococcal and streptococcal relatives were 92-94, 78 and 81 %, respectively...
October 16, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29030996/re-examining-the-sensitivity-of-glycated-hemoglobin-to-screen-for-diabetes-mellitus
#2
Chun Wei Yap, Yee Gary Ang, Timothy Peng Lim Quek, Bee Hoon Heng, Daniel Ek Kwang Chew
BACKGROUND: Glycated hemoglobin (HbA1c) is one of the laboratory tests recommended by the ADA to screen for diabetes mellitus (DM). It is particularly suitable for population segments that cannot or are unwilling to fast for a screening test. Our study aims to determine if HbA1c would be a useful tool to screen for DM in a real world setting if ADA guidelines for repeat testing to confirm the diagnosis of DM are strictly adhered to. METHODS: We carried out a retrospective database study by extracting demographic and laboratory data from a chronic disease registry which collects data on adults from three tertiary hospitals and nine large primary care clinics in Singapore...
October 14, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29030869/evaluation-of-the-predictive-performance-of-bleeding-risk-scores-in-patients-with-non-valvular-atrial-fibrillation-on-oral-anticoagulants
#3
S A Beshir, Z Aziz, L B Yap, K H Chee, Y L Lo
WHAT IS KNOWN AND OBJECTIVE: Bleeding risk scores (BRSs) aid in the assessment of oral anticoagulant-related bleeding risk in patients with atrial fibrillation. Ideally, the applicability of a BRS needs to be assessed, prior to its routine use in a population other than the original derivation cohort. Therefore, we evaluated the performance of 6 established BRSs to predict major or clinically relevant bleeding (CRB) events associated with the use of oral anticoagulant (OAC) among Malaysian patients...
October 13, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29028672/birth-cohort-consortium-of-asia-current-and-future-perspectives
#4
Reiko Kishi, Jun Jim Zhang, Eun-Hee Ha, Pau-Chung Chen, Ying Tian, Yankai Xia, Kenji J Tsuchiya, Kunihiko Nakai, Sungkyoon Kim, Soo-Jong Hong, Yun-Chul Hong, Jeong-Rim Lee, Hamid Jan B Jan Mohamed, Rajendra Prasad Parajuli, Linda S Adair, Yap Seng Chong, Yue Leon Guo, Shu-Li Wang, Muneko Nishijo, Teruhiko Kido, Pham The Tai, Sumal Nandasena
BACKGROUND: The environmental health of children is one of the great global health concerns. Exposures in utero and throughout development can have major consequences on later health. However, environmental risks or disease burdens vary from region to region. Birth cohort studies are ideal for investigating different environmental risks. METHODS: The principal investigators of three birth cohorts in Asia including the Taiwan Birth Panel Study (TBPS), the Mothers and Children's Environmental Health Study (MOCEH), and the Hokkaido Study on Environment and Children' Health (Hokkaido Study) coestablished the Birth Cohort Consortium of Asia (BiCCA) in 2011...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29024848/incorporation-of-surface-plasmon-resonance-with-novel-valinomycin-doped-chitosan-graphene-oxide-thin-film-for-sensing-potassium-ion
#5
Afiq Azri Zainudin, Yap Wing Fen, Nor Azah Yusof, Sura Hmoud Al-Rekabi, Mohd Adzir Mahdi, Nur Alia Sheh Omar
In this study, the combination of novel valinomycin doped chitosan-graphene oxide (C-GO-V) thin film and surface plasmon resonance (SPR) system for potassium ion (K(+)) detection has been developed. The novel C-GO-V thin film was deposited on the gold surface using spin coating technique. The system was used to monitor SPR signal for K(+) in solution with and without C-GO-V thin film. The K(+) can be detected by measuring the SPR signal when C-GO-V thin film is exposed to K(+) in solution. The sensor produces a linear response for K(+) ion up to 100ppm with sensitivity and detection limit of 0...
October 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29024557/body-composition-measurement-in-young-children-using-quantitative-magnetic-resonance-a-comparison-with-air-displacement-plethysmography
#6
L-W Chen, M-T Tint, M V Fortier, I M Aris, L P-C Shek, K H Tan, V S Rajadurai, P D Gluckman, Y-S Chong, K M Godfrey, M S Kramer, C J Henry, F Yap, Y S Lee
BACKGROUND: Quantitative magnetic resonance (QMR) has been increasingly used to measure human body composition, but its use and validation in children is limited. OBJECTIVE: We compared body composition measurement by QMR and air displacement plethysmography (ADP) in preschool children from Singapore's multi-ethnic Asian population (n = 152; mean ± SD age: 5.0 ± 0.1 years). METHODS: Agreements between QMR-based and ADP-based fat mass and fat mass index (FMI) were assessed using intraclass correlation coefficient (ICC), reduced major axis regression and Bland-Altman plot analyses...
October 12, 2017: Pediatric Obesity
https://www.readbyqxmd.com/read/29023367/effect-of-cadmium-and-copper-exposure-on-growth-secondary-metabolites-and-antioxidant-activity-in-the-medicinal-plant-sambung-nyawa-gynura-procumbens-lour-merr
#7
Mohd Hafiz Ibrahim, Yap Chee Kong, Nurul Amalina Mohd Zain
A randomized complete block (RCBD) study was designed to investigate the effects of cadmium (Cd) and copper (Cu) on the growth, bioaccumulation of the two heavy metals, metabolite content and antibacterial activities in Gyanura procumbens (Lour.) Merr. Nine treatments including (1) control (no Cd and Cu); (2) Cd 2 = cadmium 2 mg/L; (3) Cd 4 = cadmium 4 mg/L; (4) Cu 70 = copper 70 mg/L; (5) Cu 140 = copper 140 mg/L); (6) Cd 2 + Cu 70 = cadmium 2 mg/L + copper 70 mg/L); (7) Cd 2 + Cu 140 = cadmium 2 mg/L + copper 70 mg/L); (8) Cd 4 + Cu 70 = cadmium 4 mg/L+ copper 70 mg/L and (9) Cd 4 + Cu 140 = cadmium 4 mg/L + copper 140 mg/L) were evaluated in this experiment...
October 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29022384/does-the-maternal-vaginal-microbiota-play-a-role-in-seeding-the-microbiota-of-neonatal-gut-and-nose
#8
O Sakwinska, F Foata, B Berger, H Brüssow, S Combremont, A Mercenier, S Dogra, S-E Soh, J C K Yen, G Y S Heong, Y S Lee, F Yap, M J Meaney, Y-S Chong, K M Godfrey, J D Holbrook
The acquisition and early maturation of infant microbiota is not well understood despite its likely influence on later health. We investigated the contribution of the maternal microbiota to the microbiota of infant gut and nose in the context of mode of delivery and feeding. Using 16S rRNA sequencing and specific qPCR, we profiled microbiota of 42 mother-infant pairs from the GUSTO birth cohort, at body sites including maternal vagina, rectum and skin; and infant stool and nose. In our study, overlap between maternal vaginal microbiota and infant faecal microbiota was minimal, while the similarity between maternal rectal microbiota and infant microbiota was more pronounced...
October 12, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/29021588/robust-fusion-of-diffusion-mri-data-for-template-construction
#9
Zhanlong Yang, Geng Chen, Dinggang Shen, Pew-Thian Yap
Construction of brain templates is generally carried out using a two-step procedure involving registering a population of images to a common space and then fusing the aligned images to form a template. In practice, image registration is not perfect and simple averaging of the images will blur structures and cause artifacts. In diffusion MRI, this is further complicated by intra-voxel inter-subject differences in fiber orientation, fiber configuration, anisotropy, and diffusivity. In this paper, we propose a method to improve the construction of diffusion MRI templates in light of inter-subject differences...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29020634/brachyury-yap-regulatory-axis-drives-stemness-and-growth-in-cancer
#10
Sagar R Shah, Justin M David, Nathaniel D Tippens, Ahmed Mohyeldin, Juan C Martinez-Gutierrez, Sara Ganaha, Paula Schiapparelli, Duane H Hamilton, Claudia Palena, Andre Levchenko, Alfredo Quiñones-Hinojosa
Molecular factors that define stem cell identity have recently emerged as oncogenic drivers. For instance, brachyury, a key developmental transcriptional factor, is also implicated in carcinogenesis, most notably of chordoma, through mechanisms that remain elusive. Here, we show that brachyury is a crucial regulator of stemness in chordoma and in more common aggressive cancers. Furthermore, this effect of brachyury is mediated by control of synthesis and stability of Yes-associated protein (YAP), a key regulator of tissue growth and homeostasis, providing an unexpected mechanism of control of YAP expression...
October 10, 2017: Cell Reports
https://www.readbyqxmd.com/read/29019016/repurposing-zidovudine-in-combination-with-tigecycline-for-treating-carbapenem-resistant-enterobacteriaceae-infections
#11
S M S Ng, J S P Sioson, J M Yap, F M Ng, H S V Ching, J W P Teo, R Jureen, J Hill, C S B Chia
The global emergence of carbapenem-resistant Enterobacteriaceae (CRE) presents a significant clinical concern, prompting the WHO to prioritize CRE as a top priority pathogen in their 2017 global antibiotic-resistant bacteria priority list. Due to the fast-depleting antibiotic arsenal, clinicians are now resorting to using once-abandoned, highly toxic antibiotics such as the polymyxins and aminoglycosides, creating an urgent need for new antibiotics. Drug repurposing, the application of an approved drug for a new therapeutic indication, is deemed a plausible solution to this problem...
October 10, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29018944/-nonautonomous-effects-of-oncogenic-yap-in-hepatocarcinogenesis
#12
REVIEW
S Marquard, S Thomann, S M E Weiler, C Sticht, N Gretz, P Schirmacher, K Breuhahn
BACKGROUND: The transcriptional coactivator yes-associated protein (YAP) is a strong oncogene in liver cancer development. OBJECTIVES: To investigate if and how YAP-induced paracrine-acting factors are regulated in hepatocytes and liver cancer cells. MATERIAL AND METHODS: Transcriptome analysis and proteomics of murine wildtype and YAP-transgenic hepatocytes were performed to identify paracrine-acting proteins. Molecular and biochemical techniques were used to examine the mechanisms of YAP-dependent gene regulation...
October 10, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29018152/correction-cutting-edge-helminth-coinfection-blocks-effector-differentiation-of-cd8-t-cells-through-alternate-host-th2-and-il-10-mediated-responses
#13
Andrew Marple, Wenhui Wu, Suhagi Shah, Yanlin Zhao, Peicheng Du, William C Gause, George S Yap
No abstract text is available yet for this article.
October 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29017756/biomechanical-strain-induced-modulation-of-proliferation-coincides-with-an-erk1-2-independent-nuclear-yap-localization
#14
Diana Huelter-Hassler, Martin Wein, Simon D Schulz, Susanne Proksch, Thorsten Steinberg, Britta A Jung, Pascal Tomakidi
Biomechanical strain induces activation of the transcriptional co-activator yes-associated protein (YAP) by nuclear re-distribution. Recent findings indicate that the mechanically responsive mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK) 1/2 is involved in the amount of nuclear YAP, reflecting its activation. In this context, we conducted experiments to detect how biomechanical strain acts on the subcellular localization of YAP in periodontal cells. To this end, cells were subjected to 2...
October 7, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29017577/elevated-expression-of-par3-promotes-prostate-cancer-metastasis-by-forming-a-par3-apkc-kibra-complex-and-inactivating-the-hippo-pathway
#15
Pei-Jie Zhou, Wei Xue, Jinliang Peng, Yanqing Wang, Lianzi Wei, Ziqiang Yang, Helen He Zhu, Yu-Xiang Fang, Wei-Qiang Gao
BACKGROUND: Prostate cancer (PCa) is one of the most frequent tumors and leading cause of cancer deaths among males worldwide. The majority of deaths are due to recurrence and subsequent development of the metastatic cancer. Although loss or dislocalization of polarity proteins has been implicated in embryogenesis deficiency and tumorigenesis, association of polarity protein expression levels with tumor metastasis remains unclear. METHODS: Bioinformatics, qRT-PCR, western blot and immunohistochemical (IHC) analyses were used to examine expression of Par3, a key component of polarity-associated partitioning defective (PAR) complex, in primary and metastatic clinical PCa samples...
October 10, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29017363/a-survey-on-the-use-of-topical-steroids-in-patients-treated-for-lichen-sclerosus-associated-vulval-squamous-cell-carcinoma
#16
Rachel Pounds, Sanna Tahir, Christopher Dawson, Ciaran Woodman, David Luesley, Jason Yap
Evidence suggests that lichen sclerosus (LS) is the primary aetiological factor for local vulval recurrence (LVR) in vulval squamous cell carcinoma (VSCC). The long-term application of topical corticosteroids is believed to prevent LVR. Patients treated for LS-associated VSCC at a gynaecological cancer centre were invited to complete a questionnaire to evaluate whether they are receiving corticosteroids. 55 of the 95 eligible patients (58%) completed the questionnaire; LS was treated in 69%, with steroids given to 84...
October 10, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29017057/a-p53-super-tumor-suppressor-reveals-a-tumor-suppressive-p53-ptpn14-yap-axis-in-pancreatic-cancer
#17
Stephano S Mello, Liz J Valente, Nitin Raj, Jose A Seoane, Brittany M Flowers, Jacob McClendon, Kathryn T Bieging-Rolett, Jonghyeob Lee, Danton Ivanochko, Margaret M Kozak, Daniel T Chang, Teri A Longacre, Albert C Koong, Cheryl H Arrowsmith, Seung K Kim, Hannes Vogel, Laura D Wood, Ralph H Hruban, Christina Curtis, Laura D Attardi
The p53 transcription factor is a critical barrier to pancreatic cancer progression. To unravel mechanisms of p53-mediated tumor suppression, which have remained elusive, we analyzed pancreatic cancer development in mice expressing p53 transcriptional activation domain (TAD) mutants. Surprisingly, the p53(53,54) TAD2 mutant behaves as a "super-tumor suppressor," with an enhanced capacity to both suppress pancreatic cancer and transactivate select p53 target genes, including Ptpn14. Ptpn14 encodes a negative regulator of the Yap oncoprotein and is necessary and sufficient for pancreatic cancer suppression, like p53...
October 9, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29017051/tumor-suppression-by-p53-bring-in-the-hippo
#18
Yael Aylon, Moshe Oren
In this issue of Cancer Cell, Mello et al. investigated how p53 suppresses pancreatic cancer and discovered a key role for the tyrosine phosphatase PTPN14, a p53 transcriptional target. PTPN14 restrains YAP, curbing its potential oncogenic effects. The p53-PTPN14-YAP axis highlights the importance of signaling pathway coordination in cancer prevention.
October 9, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29017029/fgf10-hippo-epithelial-mesenchymal-crosstalk-maintains-and-recruits-lung-basal-stem-cells
#19
Thomas Volckaert, Tingting Yuan, Cho-Ming Chao, Harold Bell, Alina Sitaula, Luisa Szimmtenings, Elie El Agha, Diptiman Chanda, Susan Majka, Saverio Bellusci, Victor J Thannickal, Reinhard Fässler, Stijn P De Langhe
The lung harbors its basal stem/progenitor cells (BSCs) in the protected environment of the cartilaginous airways. After major lung injuries, BSCs are activated and recruited to sites of injury. Here, we show that during homeostasis, BSCs in cartilaginous airways maintain their stem cell state by downregulating the Hippo pathway (resulting in increased nuclear Yap), which generates a localized Fgf10-expressing stromal niche; in contrast, differentiated epithelial cells in non-cartilaginous airways maintain quiescence by activating the Hippo pathway and inhibiting Fgf10 expression in airway smooth muscle cells (ASMCs)...
October 9, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29016635/hiv-human-herpesvirus-co-infections-impact-on-tryptophan-kynurenine-pathway-and-immune-reconstitution
#20
Siew Hwei Yap, Noor Kamila Abdullah, Megan McStea, Kozo Takayama, Meng Li Chong, Elisa Crisci, Marie Larsson, Iskandar Azwa, Adeeba Kamarulzaman, Kok Hoong Leong, Yin Ling Woo, Reena Rajasuriar
BACKGROUND: Co-infections with human herpesvirus (HHV) have been associated with residual chronic inflammation in antiretroviral (ART)-treated human immunodeficiency virus (HIV)-infected individuals. However, the role of HHV in modulating the tryptophan-kynurenine pathway and clinical outcomes in HIV-infected individuals is poorly understood. Thus, we investigated the seroprevalence of four common HHVs among treated HIV-infected participants and their impact on kynurenine/tryptophan (K/T) ratio and long-term CD4 T-cell recovery in HIV/HHV co-infected participants...
2017: PloS One
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