keyword
https://read.qxmd.com/read/38319140/an-analysis-of-the-prognostic-role-of-reactive-oxygen-species-associated-genes-in-breast-cancer
#21
JOURNAL ARTICLE
Yangyan Zhong, Hong Cao, Wei Li, Jian Deng, Dan Li, Junjie Deng
BACKGROUND: This study aimed to type breast cancer in relation to reactive oxygen species (ROS), clinical indicators, single nucleotide variant (SNV) mutations, functional differences, immune infiltration, and predictive responses to immunotherapy or chemotherapy, and constructing a prognostic model. METHODS: We used uniCox analysis, ConsensusClusterPlus, and the proportion of ambiguous clustering (PAC) to analyze The Cancer Genome Atlas (TCGA) data to determine optimal groupings and obtain differentially expressed ROS-related genes...
February 6, 2024: Environmental Toxicology
https://read.qxmd.com/read/38310805/scale-based-entropy-measures-and-deep-learning-methods-for-analyzing-the-dynamical-characteristics-of-cardiorespiratory-control-system-in-covid-19-subjects-during-and-after-recovery
#22
JOURNAL ARTICLE
Madini O Alassafi, Wajid Aziz, Rayed AlGhamdi, Abdulrahman A Alshdadi, Malik Sajjad Ahmed Nadeem, Ishtiaq Rasool Khan, Nabeel Albishry, Adel Bahaddad, Ali Altalbe
COVID-19, known as Coronavirus Disease 2019 primarily targets the respiratory system and can impact the cardiovascular system, leading to a range of cardiorespiratory complications. The current forefront in analyzing the dynamical characteristics of physiological systems and aiding clinical decision-making involves the integration of entropy-based complexity techniques with artificial intelligence. Entropy-based measures offer promising prospects for identifying disturbances in cardiorespiratory control system (CRCS) among COVID-19 patients by assessing the oxygen saturation variability (OSV) signals...
February 1, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38297364/o2-supplementation-disambiguation-in-clinical-narratives-to-support-retrospective-covid-19-studies
#23
JOURNAL ARTICLE
Akhila Abdulnazar, Amila Kugic, Stefan Schulz, Vanessa Stadlbauer, Markus Kreuzthaler
BACKGROUND: Oxygen saturation, a key indicator of COVID-19 severity, poses challenges, especially in cases of silent hypoxemia. Electronic health records (EHRs) often contain supplemental oxygen information within clinical narratives. Streamlining patient identification based on oxygen levels is crucial for COVID-19 research, underscoring the need for automated classifiers in discharge summaries to ease the manual review burden on physicians. METHOD: We analysed text lines extracted from anonymised COVID-19 patient discharge summaries in German to perform a binary classification task, differentiating patients who received oxygen supplementation and those who did not...
January 31, 2024: BMC Medical Informatics and Decision Making
https://read.qxmd.com/read/38293069/intracranial-pressure-flow-relationships-in-traumatic-brain-injury-patients-expose-gaps-in-the-tenets-of-models-and-pressure-oriented-management
#24
J N Stroh, Brandon Foreman, Tellen D Bennett, Jennifer K Briggs, Soojin Park, David J Albers
BACKGROUND: The protocols and therapeutic guidance established for treating traumatic brain injuries (TBI) in neurointensive care focus on managing cerebral blood flow (CBF) and brain tissue oxygenation based on pressure signals. The decision support process relies on assumed relationships between cerebral perfusion pressure (CPP) and blood flow, pressure-flow relationships (PFRs), and shares this framework of assumptions with mathematical intracranial hemodynamic models. These foundational assumptions are difficult to verify, and their violation can impact clinical decision-making and model validity...
January 18, 2024: medRxiv
https://read.qxmd.com/read/38287435/development-and-validation-of-a-nomogram-for-predicting-in-hospital-mortality-of-patients-with-cervical-spine-fractures-without-spinal-cord-injury
#25
JOURNAL ARTICLE
Zhibin Xing, Lingli Cai, Yuxuan Wu, Pengfei Shen, Xiaochen Fu, Yiwen Xu, Jing Wang
BACKGROUND: The incidence of cervical spine fractures is increasing every day, causing a huge burden on society. This study aimed to develop and verify a nomogram to predict the in-hospital mortality of patients with cervical spine fractures without spinal cord injury. This could help clinicians understand the clinical outcome of such patients at an early stage and make appropriate decisions to improve their prognosis. METHODS: This study included 394 patients with cervical spine fractures from the Medical Information Mart for Intensive Care III database, and 40 clinical indicators of each patient on the first day of admission to the intensive care unit were collected...
January 29, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38282353/nasal-high-flow-therapy-in-remote-hospitals-guideline-development-using-a-modified-delphi-technique
#26
JOURNAL ARTICLE
Sally West, Donna Franklin, Nichole Harvey, Alice Cairns
INTRODUCTION: In remote Australian hospitals there are no onsite paediatric intensive care units (PICUs), increasing the reliance on aeromedical retrieval to access tertiary care. Nasal high flow (NHF) therapy is an oxygen therapy used in tertiary hospitals to treat paediatric patients with respiratory conditions. In rural and remote Queensland, Australia, the use of NHF therapy is inconsistent and there are no guidelines on how this therapy should be implemented in practice. Therefore, three remote hospitals within the Torres Strait and Cape York commenced a project to improve consistent and equitable access to NHF therapy...
January 2024: Rural and Remote Health
https://read.qxmd.com/read/38282021/cardiovascular-biomarkers-exploring-troponin-and-bnp-applications-in-conditions-related-to-carbon-monoxide-exposure
#27
REVIEW
Andia Taghdiri
BACKGROUND: The diagnosis and prognosis of cardiovascular disorders are greatly aided by cardiovascular biomarkers. The uses of troponin and B-type natriuretic peptide in situations involving carbon monoxide exposure are examined in this narrative review. These biomarkers are important because they help predict outcomes in cardiovascular disorders, track the effectiveness of therapy, and influence therapeutic choices. MAIN BODY: Clinical practice makes considerable use of B-type natriuretic peptide (BNP), which has diuretic and vasodilatory effects, and troponin, a particular marker for myocardial injury...
January 29, 2024: Egyptian Heart Journal: EHJ
https://read.qxmd.com/read/38271366/a-nomogram-for-predicting-mortality-risk-within-30-days-in-sepsis-patients-admitted-in-the-emergency-department-a-retrospective-analysis
#28
JOURNAL ARTICLE
Bin Wang, Jianping Chen, Xinling Pan, Bingzheng Xu, Jian Ouyang
OBJECTIVE: To establish and validate an individualized nomogram to predict mortality risk within 30 days in patients with sepsis from the emergency department. METHODS: Data of 1205 sepsis patients who were admitted to the emergency department in a tertiary hospital between Jun 2013 and Sep 2021 were collected and divided into a training group and a validation group at a ratio of 7:3. The independent risk factors related to 30-day mortality were identified by univariate and multivariate analysis in the training group and used to construct the nomogram...
2024: PloS One
https://read.qxmd.com/read/38227552/exploring-the-impact-of-pericentric-inversion-of-chromosome-9-on-fertility-in-sperm-donors
#29
JOURNAL ARTICLE
Qian Liu, Wen-Jun Zhou, Zeng-Hui Huang, Xiu-Hai Huang, Jian Wu, Xi-Ren Ji, Xue-Feng Luo, Yu-Ling Tang, Rui-Jun Wang, Li-Qing Fan, Chuan Huang, Wen-Bing Zhu
Pericentric inversion of chromosome 9 (inv[9]) is a common chromosomal structural variant, but its impact on clinical outcomes remains debated. The screening criteria of sperm banks are rarely mentioned to individuals with inv(9). In this study, we evaluated the fertility of sperm donors with inv(9) who met eligibility criteria for sperm banks (inv[9]-eligible donors). From March 2004 to May 2022, chromosomal analysis of 16 124 sperm donors at CITIC-Xiangya Human Sperm Bank in Hunan Province (Changsha, China) found that 251 (1...
January 12, 2024: Asian Journal of Andrology
https://read.qxmd.com/read/38223058/flow-augmentation-sta-mca-bypass-for-acute-and-subacute-ischemic-stroke-due-to-internal-carotid-artery-occlusion-and-the-role-of-advanced-neuroimaging-with-hemodynamic-and-flow-measurement-in-the-decision-making-preliminary-data
#30
JOURNAL ARTICLE
Martina Sebök, Lara Maria Höbner, Jorn Fierstra, Tilman Schubert, Susanne Wegener, Zsolt Kulcsár, Andreas R Luft, Luca Regli, Giuseppe Esposito
BACKGROUND: A major clinical challenge is the adequate identification of patients with acute (<1 week) and subacute (1-6 weeks) ischemic stroke due to internal carotid artery (ICA) occlusion who could benefit from a surgical revascularization after a failure of endovascular and/or medical treatment. Recently, two novel quantitative imaging modalities have been introduced: (I) quantitative magnetic resonance angiography (qMRA) with non-invasive optimal vessel analysis (NOVA) for quantification of blood flow in major cerebral arteries (in mL/min), and (II) blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging to assess cerebrovascular reactivity (CVR)...
January 3, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38217387/the-integrated-stress-response-related-expression-of-chop-due-to-mitochondrial-toxicity-is-a-warning-sign-for-dili-liability
#31
JOURNAL ARTICLE
Matthijs Vlasveld, Giulia Callegaro, Ciarán Fisher, Julie Eakins, Paul Walker, Samantha Lok, Siddh van Oost, Brechtje de Jong, Damiano Pellegrino-Coppola, Gerhard Burger, Steven Wink, Bob van de Water
BACKGROUND AND AIMS: Drug-induced liver injury (DILI) is one of the most frequent reasons for failure of drugs in clinical trials or market withdrawal. Early assessment of DILI risk remains a major challenge during drug development. Here, we present a mechanism-based weight-of-evidence approach able to identify certain candidate compounds with DILI liabilities due to mitochondrial toxicity. METHODS: A total of 1587 FDA-approved drugs and 378 kinase inhibitors were screened for cellular stress response activation associated with DILI using an imaging-based HepG2 BAC-GFP reporter platform including the integrated stress response (CHOP), DNA damage response (P21) and oxidative stress response (SRXN1)...
January 13, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38216885/value-of-blood-oxygenation-level-dependent-magnetic-resonance-imaging-in-early-evaluation-of-the-response-and-prognosis-of-esophageal-squamous-cell-carcinoma-treated-with-definitive-chemoradiotherapy-a-preliminary-study
#32
JOURNAL ARTICLE
Huanhuan Zheng, Hailong Zhang, Yan Zhu, Xiaolei Wei, Song Liu, Wei Ren
BACKGROUND: To find a useful hypoxia non-invasive biomarker for evaluating early treatment response and prognosis to definitive chemoradiotherapy (dCRT) in patients with esophageal squamous cell carcinoma (ESCC), using blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI). METHODS: The R2* values were obtained pre- and 2-3 weeks post-dCRT in 28 patients with ESCC using BOLD MRI. Independent samples t-test (normality) or Mann-Whitney U test (non-normality) was used to compare the differences of R2*-related parameters between the complete response (CR) and the non-CR groups...
January 12, 2024: BMC Medical Imaging
https://read.qxmd.com/read/38206939/utilizing-machine-learning-for-survival-analysis-to-identify-risk-factors-for-covid-19-intensive-care-unit-admission-a-retrospective-cohort-study-from-the-united-arab-emirates
#33
JOURNAL ARTICLE
Aamna AlShehhi, Taleb M Almansoori, Ahmed R Alsuwaidi, Hiba Alblooshi
BACKGROUND: The current situation of the unprecedented COVID-19 pandemic leverages Artificial Intelligence (AI) as an innovative tool for addressing the evolving clinical challenges. An example is utilizing Machine Learning (ML) models-a subfield of AI that take advantage of observational data/Electronic Health Records (EHRs) to support clinical decision-making for COVID-19 cases. This study aimed to evaluate the clinical characteristics and risk factors for COVID-19 patients in the United Arab Emirates utilizing EHRs and ML for survival analysis models...
2024: PloS One
https://read.qxmd.com/read/38193777/formal-ethics-consultation-in-extracorporeal-membrane-oxygenation-patients-a-single-center-retrospective-cohort-of-a-quaternary-pediatric-hospital
#34
JOURNAL ARTICLE
Bryan Siegel, Lisa S Taylor, Faraz Alizadeh, Jessica A Barreto, Dennis Daniel, Peta M A Alexander, Stuart Lipsitz, Katie Moynihan
OBJECTIVE: To examine characteristics associated with formal ethics consultation (EC) referral in pediatric extracorporeal membrane oxygenation (ECMO) cases, and document ethical issues presented. DESIGN: Retrospective cohort study using mixed methods. SETTING: Single-center quaternary pediatric hospital. PATIENTS: Patients supported on ECMO (January 2012 to December 2021). INTERVENTIONS: We compared clinical variables among ECMO patients according to the presence of EC...
January 9, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38179691/novel-oxygenation-and-saturation-indices-for-mortality-prediction-in-covid-19-ards-patients-the-impact-of-driving-pressure-and-mechanical-power
#35
JOURNAL ARTICLE
Sinan Aşar, Fatih Rahim, Payam Rahimi, Özlem Acicbe, Furkan Tontu, Zafer Çukurova
Background: The oxygenation index (OI) and oxygen saturation index (OSI) are proven mortality predictors in pediatric and adult patients, traditionally using mean airway pressure (Pmean ). We introduce novel indices, replacing Pmean with DP (ΔPinsp ), MPdyn , and MPtot , assessing their potential for predicting COVID-19 acute respiratory distress syndrome (ARDS) mortality, comparing them to traditional indices. Methods: We studied 361 adult COVID-19 ARDS patients for 7 days, collecting ΔPinsp , MPdyn , and MPtot , OI-ΔPinsp , OI-MPdyn , OI-MPtot , OSI-ΔPinsp , OSI-MPdyn , and OSI-MPtot ...
January 5, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38179382/a-perioperative-blood-management-algorithm-aimed-at-conservation-of-platelets-in-clinical-practice-the-role-of-the-anesthesiologist-in-decision-making
#36
REVIEW
Kimberly L Skidmore, Naina Singh, Anusha Kallurkar, Hayden Cagle, Van S Smith Iii, Giustino Varrassi, Sahar Shekoohi, Alan Kaye
Platelet dysfunction and thrombocytopenia are associated with postoperative morbidity not only from modifiable preoperative factors but also from a lack of local patient blood management algorithms. In this regard, platelet transfusions have risen after the COVID-19 pandemic. Simultaneously, there has been a shortage of donors. It is logical, therefore, that each hospital should develop a triage tool, posting their algorithm on walls. Anesthesiologists should assist in planning a strategy to minimize blood transfusions while improving tissue oxygenation...
December 2023: Curēus
https://read.qxmd.com/read/38170527/development-and-validation-of-the-covid-19-hospitalized-patient-deterioration-index
#37
JOURNAL ARTICLE
Claudia Nau, Rebecca K Butler, Cheng-Wei Huang, Vang Kou Khang, Aiyu Chen, Beth Creekmur, Benjamin Broder, Christopher Subject, Adam L Sharp, Luis M Moreta-Sainz, Joon S Park, Akshay J Manek, Robert M Cooper, Sergio M Mendoza, Gang Luo, Michael K Gould
OBJECTIVES: To develop a COVID-19-specific deterioration index for hospitalized patients: the COVID Hospitalized Patient Deterioration Index (COVID-HDI). This index builds on the proprietary Epic Deterioration Index, which was not developed for predicting respiratory deterioration events among patients with COVID-19. STUDY DESIGN: A retrospective observational cohort was used to develop and validate the COVID-HDI model to predict respiratory deterioration or death among hospitalized patients with COVID-19...
December 1, 2023: American Journal of Managed Care
https://read.qxmd.com/read/38167289/validation-of-oxygen-saturations-measured-in-the-community-by-emergency-medical-services-as-a-marker-of-clinical-deterioration-in-patients-with-confirmed-covid-19-a-retrospective-cohort-study
#38
JOURNAL ARTICLE
Matthew Inada-Kim, Francis P Chmiel, Michael Boniface, Daniel Burns, Helen Pocock, John Black, Charles Deakin
OBJECTIVES: To evaluate oxygen saturation and vital signs measured in the community by emergency medical services (EMS) as clinical markers of COVID-19-positive patient deterioration. DESIGN: A retrospective data analysis. SETTING: Patients were conveyed by EMS to two hospitals in Hampshire, UK, between 1 March 2020 and 31 July 2020. PARTICIPANTS: A total of 1080 patients aged ≥18 years with a COVID-19 diagnosis were conveyed by EMS to the hospital...
January 2, 2024: BMJ Open
https://read.qxmd.com/read/38161187/device-related-thrombosis-and-bleeding-in-pediatric-health-care-a-meta-analysis
#39
JOURNAL ARTICLE
Amanda Ullman, Areum Hyun, Victoria Gibson, Fiona Newall, Mari Takashima
CONTEXT: The risk of invasive device-related thrombosis and bleeding contributes to morbidity and mortality, yet their prevalence by device-types is poorly understood. OBJECTIVES: This study aimed to estimate pooled proportions and rates of thrombotic and bleeding complications associated with invasive devices in pediatric health care. DATA SOURCES: Medline, CINAHL, Embase, Web of Science, Scopus, Cochrane CENTRAL, clinical trial registries, and unpublished study databases were searched...
January 1, 2024: Hospital Pediatrics
https://read.qxmd.com/read/38154738/prognostic-factors-associated-with-mortality-in-acute-exacerbations-of-idiopathic-pulmonary-fibrosis-a-systematic-review-and-meta-analysis
#40
JOURNAL ARTICLE
Tyler Pitre, Daniel Lupas, Ibrahim Ebeido, Alexander Colak, Mihir Modi, George V Kachkovski, Sydney B Montesi, Yet H Khor, Leticia Kawano-Dourado, Gisli Jenkins, Jolene H Fisher, Shane Shapera, Bram Rochwerg, Rachel Couban, Dena Zeraatkar
BACKGROUND: Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) increases mortality risk, but which factors increase mortality is unknown. We aimed to perform a prognostic review of factors associated with mortality in patients with IPF. STUDY DESIGN: and methods: We searched MEDLINE, EMBASE, and CINAHL for studies that reported on the association between any prognostic factor and AE-IPF. We assessed risk of bias using the QUIPS tool. We conduced pairwise meta-analyses using REML heterogeneity estimator, and GRADE approach to assess the certainty of the evidence...
February 2024: Respiratory Medicine
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