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Renalase

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https://www.readbyqxmd.com/read/29476431/renalase-contributes-to-protection-against-renal-fibrosis-via-inhibiting-oxidative-stress-in-rats
#1
Yiru Wu, Liyan Wang, Xiaoqi Wang, Yahui Wang, Qidong Zhang, Wenhu Liu
BACKGROUND: Renal interstitial fibrosis (RIF) is a common pathway for progression of chronic kidney disease (CKD) to end-stage renal disease. In our previous study, it has been provided that renalase can ameliorate renal interstitial fibrosis in unilateral ureteral obstruction (UUO) rats. The other mechanism of renalase to alleviate renal fibrosis should be explored. MATERIALS AND METHODS: In this study, we evaluated the role of oxidative stress in UUO rats and epithelial-mesenchymal transition (EMT) in human proximal renal tubular epithelial (HK-2) cells and examined the association of renalase...
February 23, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29172403/circulating-renalase-predicts-all-cause-mortality-and-renal-outcomes-in-patients-with-advanced-chronic-kidney-disease
#2
Seon Ha Baek, Ran-Hui Cha, Shin Wook Kang, Cheol Whee Park, Dae Ryong Cha, Sung Gyun Kim, Sun Ae Yoon, Sejoong Kim, Sang-Youb Han, Jung Hwan Park, Jae Hyun Chang, Chun Soo Lim, Yon Su Kim, Ki Young Na
Background/Aims: Patients with chronic kidney disease (CKD) have been found to show markedly increased rates of end-stage renal disease, major adverse cardiovascular and cerebrovascular events (MACCEs), and mortality. Therefore, new biomarkers are required for the early detection of such clinical outcomes in patients with CKD. We aimed to determine whether the level of circulating renalase was associated with CKD progression, MACCEs, and all-cause mortality, using data from a prospective randomized controlled study, Kremezin STudy Against Renal disease progression in Korea (K-STAR; NCT 00860431)...
November 29, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29065134/functional-polymorphism-of-the-renalase-gene-is-associated-with-cardiac-hypertrophy-in-female-patients-with-aortic-stenosis
#3
Ewa Orlowska-Baranowska, Lucja Gadomska Vel Betka, Jaroslaw Gora, Rafal Baranowski, Ewa Pedzich-Placha, Dariusz Zakrzewski, Angelika Dlugosz, Helena Kossowska, Agnieszka Zebrowska, Ewelina Zakoscielna, Anna Janiszewska, Tomasz Hryniewiecki, Zbigniew Gaciong, Grzegorz Placha
Renalase decreases circulating catecholamines concentration and is important in maintaining primary cellular metabolism. Renalase acts through the plasma membrane calcium ATPase 4b in the heart, which affects pressure overload but not exercise induced heart hypertrophy. The aim of this study was to test the association between a functional polymorphism Glu37Asp (rs2296545) of the renalase gene and left ventricular hypertrophy in a large cohort of patients with aortic stenosis. The study group consisted of 657 patients with aortic stenosis referred for aortic valve replacement...
2017: PloS One
https://www.readbyqxmd.com/read/29042438/the-serum-protein-renalase-reduces-injury-in-experimental-pancreatitis
#4
Thomas R Kolodecik, Anamika M Reed, Kimie Date, Christine A Shugrue, Vikhil Patel, Shang-Lin Chung, Gary V Desir, Fred S Gorelick
Acute pancreatitis is a disease associated with inflammation and tissue damage. One protein that protects against acute injury, including ischemic injury to both the kidney and heart, is renalase, which is secreted into the blood by the kidney and other tissues. However, whether renalase reduces acute injury associated with pancreatitis is unknown. Here, we used both in vitro and in vivo murine models of acute pancreatitis to study renalase's effects on this condition. In isolated pancreatic lobules, pretreatment with recombinant human renalase (rRNLS) blocked zymogen activation caused by cerulein, carbachol, and a bile acid...
December 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28954489/levels-of-renalase-and-advanced-oxidation-protein-products-with-regard-to-catecholamines-in-haemodialysed-patients
#5
Marcin Dziedzic, Ewelina Orłowska, Beata Petkowicz, Anna Bednarek-Skublewska, Janusz Solski, Małgorzata Goździewska
INTRODUCTION: The main mediators of the sympathetic nervous system in the effectors part are catecholamines (CA). An increased sympathetic nerve activity observed in chronic kidney disease (CKD), is due to a raised level of CA in plasma. Renalase is a protein secreted by the kidneys, composed of 342 amino acids, which is able to metabolize the circulating CA and possibly play an important role in the regulation of sympathetic tone and blood pressure. Also, oxidative stress, defined as a disruption of the equilibrium between the generation of oxidants, is a crucial factor in the development of the inflammatory syndrome associated with CKD...
September 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28915965/can-cerebellin-and-renalase-measurements-contribute-to-the-elimination-of-false-positive-results-in-pheochromocytoma-and-paraganglioma-diagnoses
#6
EDITORIAL
Suleyman Aydin
No abstract text is available yet for this article.
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28862601/-comparative-analysis-of-expression-of-genes-encoding-enzymes-of-catecholamine-catabolism-and-renalase-in-tissues-of-normotensive-and-hypertensive-rats
#7
V I Fedchenko, A E Medvedev
Comparative analysis of expression of genes encoding enzymes of catecholamine catabolism (monoaminbe oxidases A and B (MAO A and MAO B) and catechol-O-methyl transferase (COMT)) and renalase has been carried out in tissues of normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). Among investigated tissues the highest level of mRNA of genes encoding key enzymes of catecholamine catabolism (MAO A, MAO B, COMT) was found in the heart of WKY rats. In SHR the mRNA levels of these genes were lower (p<0...
July 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/28617168/renalase-assessment-with-regard-to-kidney-function-lipid-disturbances-and-endothelial-dysfunction-parameters-in-stable-renal-transplant-recipients
#8
Dijana Stojanovic, Tatjana Cvetkovic, Miodrag Stojanovic, Nikola Stefanovic, Radmila Velickovic-Radovanovic, Natasa Zivkovic
BACKGROUND: Renal transplant dysfunction has been shown to be independent predictor for premature cardiovascular disease and mortality. Renalase, a flavoprotein secreted by several tissues, including the kidney, has been found to regulate sympathetic tone and blood pressure. The purpose of this secondary analysis was to explore relationships among parameters of endothelial dysfunction, lipids, glomerular filtration rate, and renalase in 2 groups: renal transplant patients with controlled hypertension and healthy volunteers...
June 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/28614373/relationship-between-microrna-146a-expression-and-plasma-renalase-levels-in-hemodialyzed-patients
#9
Marcin Dziedzic, Tomasz Powrózek, Ewelina Orłowska, Wojciech Koch, Wirginia Kukula-Koch, Kinga Gaweł, Anna Bednarek-Skublewska, Teresa Małecka-Massalska, Janusz Milanowski, Beata Petkowicz, Janusz Solski
BACKGROUND: microRNA (miRNA) belongs to the non-coding RNAs family responsible for the regulation of gene expression. Renalase is a protein composed of 342 amino acids, secreted by the kidneys and possibly plays an important role in the regulation of sympathetic tone and blood pressure. The aim of the present study was to investigate plasma renalase concentration, and explore the relationship between miRNA-146a-5p expression and plasma renalase levels in hemodialyzed patients. METHODS: The study population comprised 55 subjects who succumbed to various cardiac events, 27 women and 28 men, aged 65-70 years...
2017: PloS One
https://www.readbyqxmd.com/read/28558965/the-enzyme-renalase
#10
REVIEW
Graham R Moran, Matthew R Hoag
Within the last two years catalytic substrates for renalase have been identified, some 10 years after its initial discovery. 2- and 6-dihydronicotinamide (2- and 6-DHNAD) isomers of β-NAD(P)H (4-dihydroNAD(P)) are rapidly oxidized by renalase to form β-NAD(P)+ . The two electrons liberated are then passed to molecular oxygen by the renalase FAD cofactor forming hydrogen peroxide. This activity would appear to serve an intracellular detoxification/metabolite repair function that alleviates inhibition of primary metabolism dehydrogenases by 2- and 6-DHNAD molecules...
October 15, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28448446/renalase-protects-against-renal-fibrosis-by-inhibiting-the-activation-of-the-erk-signaling-pathways
#11
Yiru Wu, Liyan Wang, Dai Deng, Qidong Zhang, Wenhu Liu
Renal interstitial fibrosis is a common pathway for the progression of chronic kidney disease (CKD) to end-stage renal disease. Renalase, acting as a signaling molecule, has been reported to have cardiovascular and renal protective effects. However, its role in renal fibrosis remains unknown. In this study, we evaluated the therapeutic efficacy of renalase in rats with complete unilateral ureteral obstruction (UUO) and examined the inhibitory effects of renalase on transforming growth factor-β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) in human proximal renal tubular epithelial (HK-2) cells...
April 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28405891/renalase-in-children-with-glomerular-kidney-diseases
#12
Piotr Skrzypczyk, Joanna Przychodzień, Małgorzata Mizerska-Wasiak, Elżbieta Kuźma-Mroczkowska, Magdalena Okarska-Napierała, Elżbieta Górska, Anna Stelmaszczyk-Emmel, Urszula Demkow, Małgorzata Pańczyk-Tomaszewska
Studies suggest that renalase, a renal catecholamine-inactivating enzyme, plays a major role in the pathogenesis of kidney and cardiovascular diseases in adults. This study seeks to determine the role of renalase in children with glomerular kidney diseases. We evaluated the serum renalase, arterial stiffness, intima-media thickness, blood pressure, and clinical and biochemical parameters in 78 children (11.9 ± 4.6 years of age) with glomerulopathies such as idiopathic nephrotic syndrome (40 cases), IgA nephropathy (12 cases), Henoch-Schönlein nephropathy (12 cases), and other glomerulopathies (14 cases)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28372594/rs10887800-renalase-gene-polymorphism-influences-the-level-of-circulating-renalase-in-patients-undergoing-hemodialysis-but-not-in-healthy-controls
#13
Anna Stec
BACKGROUND: Human renalase (RNLS), a recently identified flavoprotein with oxidoreductase activity, is secreted into blood by kidneys and metabolizes circulating catecholamines. Recent studies have revealed that common polymorphisms in RNLS gene might affect the risk of several cardiovascular conditions in hemodialyzed patients. However, the exact mechanism underlying this link remains unclear. The study aims to investigate the association between RNLS gene polymorphisms and plasma renalase level in ESKD patients undergoing hemodialysis (HD group) and healthy controls (HC)...
April 3, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28273198/effects-and-mechanisms-of-radiofrequency-ablation-of-renal-sympathetic-nerve-on-anti-hypertension-in-canine
#14
Wei Chen, Xiaohong Tang, Xiaofang Yang, Chunyan Weng, Kan Yang, Juan Wen, Hong Liu, Yang Wu
BACKGROUND: Radiofrequency ablation of renal sympathetic nerve (RDN) shows effective BP reduction in hypertensive patients while the specific mechanisms remain unclear. OBJECTIVE: We hypothesized that abnormal levels of norepinephrine (NE) and changes in NE-related enzymes and angiotensinconverting enzyme 2 (ACE2), angiotensin (Ang)-(1-7) and Mas receptor mediate the anti-hypertensive effects of RDN. METHODS: Mean values of systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were assessed at baseline and follow-up...
March 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28238213/extracellular-renalase-protects-cells-and-organs-by-outside-in-signalling
#15
REVIEW
Yang Wang, Robert Safirstein, Heino Velazquez, Xiao-Jia Guo, Lindsay Hollander, John Chang, Tian-Min Chen, Jian-Jun Mu, Gary V Desir
Renalase was discovered as a protein synthesized by the kidney and secreted in blood where it circulates at a concentration of approximately 3-5 μg/ml. Initial reports suggested that it functioned as an NAD(P)H oxidase and could oxidize catecholamines. Administration of renalase lowers blood pressure and heart rate and also protects cells and organs against ischaemic and toxic injury. Although renalase's protective effect was initially ascribed to its oxidase properties, a paradigm shift in our understanding of the cellular actions of renalase is underway...
July 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28160962/increased-serum-renalase-in-peritoneal-dialysis-patients-is-it-related-to-cardiovascular-disease-risk
#16
Ebru Gok Oguz, Hadim Akoglu, Gulay Ulusal Okyay, Guner Karaveli Gursoy, Tolga Yildirim, Ozgur Merhametsiz, Tolga Cimen, Basol Canbakan, Ekrem Yeter, M Deniz Ayli
BACKGROUND: Renalase, with possible monoamine oxidase activity, is implicated in degradation of catecholamines; which suggests novel mechanisms of cardiovascular complications in patients with chronic kidney diseases. Epicardial adipose tissue (EAT) has been found to correlate with cardiovascular diseases (CVD) in dialysis patients. The present study aimed to evaluate the association of serum renalase levels with EAT thickness and other CVD risk factors in peritoneal dialysis (PD) patients...
March 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/27871085/plasma-renalase-is-not-associated-with-blood-pressure-and-brachial-ankle-pulse-wave-velocity-in-chinese-adults-with-normal-renal-function
#17
Yang Wang, Yong-Bo Lv, Chao Chu, Man Wang, Bing-Qing Xie, Lan Wang, Fan Yang, Ding-Yi Yan, Rui-Hai Yang, Jun Yang, Yong Ren, Zu-Yi Yuan, Jian-Jun Mu
BACKGROUND/AIMS: This study aimed to investigate the association of renalase with blood pressure (BP) and brachial-ankle pulse wave velocity (baPWV) in order to better understand the role of renalase in the pathogenesis of hypertension and atherosclerosis. METHODS: A total of 344 subjects with normal kidney function were recruited from our previously established cohort in Shaanxi Province, China. They were divided into the normotensive (NT) and hypertensive (HT) groups or high baPWV and normal baPWV on the basis of BP levels or baPWV measured with an automatic waveform analyzer...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27868059/intramyocardial-injection-of-sirnas-can-efficiently-establish-myocardial-tissue-specific-renalase-knockdown-mouse-model
#18
Kun Huang, Ju Liu, Hui Zhang, Jiliang Wang, Huili Li
Ischaemia/reperfusion (I/R) injury will cause additional death of cardiomyocytes in ischaemic heart disease. Recent studies revealed that renalase was involved in the I/R injury. So, the myocardial tissue-specific knockdown mouse models were needed for the investigations of renalase. To establish the mouse models, intramyocardial injection of siRNAs targeting renalase was performed in mice. The wild distribution and high transfection efficiency of the siRNAs were approved. And the renalase expression was efficiently suppressed in myocardial tissue...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27867452/renalase-as-a-novel-biomarker-for-evaluating-the-severity-of-hepatic-ischemia-reperfusion-injury
#19
Huili Li, Jianrong Guo, Hongli Liu, Yanfeng Niu, Lixia Wang, Kun Huang, Jiliang Wang
Hepatic ischemia-reperfusion (I/R) injury is a serious complication in clinical practice. However, no efficient biomarkers are available for the evaluation of the severity of I/R injury. Recently, renalase has been reported to be implicated in the I/R injury of various organs. This protein is secreted into the blood in response to increased oxidative stress. To investigate the responsiveness of renalase to oxidative stress, we examined the changes of renalase in cell and mouse models. We observed a significant increase of renalase expression in HepG2 cells in a time- and dose-dependent manner when treated with H2O2...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27822026/age-influence-on-renalase-and-catecholamines-concentration-in-hypertensive-patients-including-maintained-dialysis
#20
Edyta Zbroch, Dominika Musialowska, Ewa Koc-Zorawska, Jolanta Malyszko
BACKGROUND: Hypertension in elderly patients is one of the main problems in cardiovascular diseases. The sympathetic nervous system hyperactivity seen in older patients is a known risk factor for hypertension and other cardiovascular events as well as chronic kidney disease. Renalase, secreted by the kidney and circulated in blood, may regulate the sympathetic tone by catecholamine degradation and in this way has an impact on cardiovascular and renal complications. OBJECTIVE: To assess the impact of age on renalase and catecholamine concentration in hypertensive patients, including those on dialyses and its possible relation to blood pressure control and cardiovascular disease...
2016: Clinical Interventions in Aging
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