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Renalase

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https://www.readbyqxmd.com/read/28273198/effects-and-mechanisms-of-radiofrequency-ablation-of-renal-sympathetic-nerve-on-anti-hypertension-in-canine
#1
Wei Chen, Xiaohong Tang, Xiaofang Yang, Chunyan Weng, Kan Yang, Juan Wen, Hong Liu, Yang Wu
Background: Radiofrequency ablation of renal sympathetic nerve (RDN) shows effective BP reduction in hypertensive patients while the specific mechanisms remain unclear. Objective: We hypothesized that abnormal levels of norepinephrine (NE) and changes in NE-related enzymes and angiotensinconverting enzyme 2 (ACE2), angiotensin (Ang)-(1-7) and Mas receptor mediate the anti-hypertensive effects of RDN. Methods: Mean values of systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were assessed at baseline and follow-up...
March 6, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28238213/extracellular-renalase-protects-cells-and-organs-by-outside-in-signalling
#2
REVIEW
Yang Wang, Robert Safirstein, Heino Velazquez, Xiao-Jia Guo, Lindsay Hollander, John Chang, Tian-Min Chen, Jian-Jun Mu, Gary V Desir
Renalase was discovered as a protein synthesized by the kidney and secreted in blood where it circulates at a concentration of approximately 3-5 μg/ml. Initial reports suggested that it functioned as an NAD(P)H oxidase and could oxidize catecholamines. Administration of renalase lowers blood pressure and heart rate and also protects cells and organs against ischaemic and toxic injury. Although renalase's protective effect was initially ascribed to its oxidase properties, a paradigm shift in our understanding of the cellular actions of renalase is underway...
February 26, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28160962/increased-serum-renalase-in-peritoneal-dialysis-patients-is-it-related-to-cardiovascular-disease-risk
#3
Ebru Gok Oguz, Hadim Akoglu, Gulay Ulusal Okyay, Guner Karaveli Gursoy, Tolga Yildirim, Ozgur Merhametsiz, Tolga Cimen, Basol Canbakan, Ekrem Yeter, M Deniz Ayli
BACKGROUND: Renalase, with possible monoamine oxidase activity, is implicated in degradation of catecholamines; which suggests novel mechanisms of cardiovascular complications in patients with chronic kidney diseases. Epicardial adipose tissue (EAT) has been found to correlate with cardiovascular diseases (CVD) in dialysis patients. The present study aimed to evaluate the association of serum renalase levels with EAT thickness and other CVD risk factors in peritoneal dialysis (PD) patients...
February 1, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/27871085/plasma-renalase-is-not-associated-with-blood-pressure-and-brachial-ankle-pulse-wave-velocity-in-chinese-adults-with-normal-renal-function
#4
Yang Wang, Yong-Bo Lv, Chao Chu, Man Wang, Bing-Qing Xie, Lan Wang, Fan Yang, Ding-Yi Yan, Rui-Hai Yang, Jun Yang, Yong Ren, Zu-Yi Yuan, Jian-Jun Mu
BACKGROUND/AIMS: This study aimed to investigate the association of renalase with blood pressure (BP) and brachial-ankle pulse wave velocity (baPWV) in order to better understand the role of renalase in the pathogenesis of hypertension and atherosclerosis. METHODS: A total of 344 subjects with normal kidney function were recruited from our previously established cohort in Shaanxi Province, China. They were divided into the normotensive (NT) and hypertensive (HT) groups or high baPWV and normal baPWV on the basis of BP levels or baPWV measured with an automatic waveform analyzer...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27868059/intramyocardial-injection-of-sirnas-can-efficiently-establish-myocardial-tissue-specific-renalase-knockdown-mouse-model
#5
Kun Huang, Ju Liu, Hui Zhang, Jiliang Wang, Huili Li
Ischaemia/reperfusion (I/R) injury will cause additional death of cardiomyocytes in ischaemic heart disease. Recent studies revealed that renalase was involved in the I/R injury. So, the myocardial tissue-specific knockdown mouse models were needed for the investigations of renalase. To establish the mouse models, intramyocardial injection of siRNAs targeting renalase was performed in mice. The wild distribution and high transfection efficiency of the siRNAs were approved. And the renalase expression was efficiently suppressed in myocardial tissue...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27867452/renalase-as-a-novel-biomarker-for-evaluating-the-severity-of-hepatic-ischemia-reperfusion-injury
#6
Huili Li, Jianrong Guo, Hongli Liu, Yanfeng Niu, Lixia Wang, Kun Huang, Jiliang Wang
Hepatic ischemia-reperfusion (I/R) injury is a serious complication in clinical practice. However, no efficient biomarkers are available for the evaluation of the severity of I/R injury. Recently, renalase has been reported to be implicated in the I/R injury of various organs. This protein is secreted into the blood in response to increased oxidative stress. To investigate the responsiveness of renalase to oxidative stress, we examined the changes of renalase in cell and mouse models. We observed a significant increase of renalase expression in HepG2 cells in a time- and dose-dependent manner when treated with H2O2...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27822026/age-influence-on-renalase-and-catecholamines-concentration-in-hypertensive-patients-including-maintained-dialysis
#7
Edyta Zbroch, Dominika Musialowska, Ewa Koc-Zorawska, Jolanta Malyszko
BACKGROUND: Hypertension in elderly patients is one of the main problems in cardiovascular diseases. The sympathetic nervous system hyperactivity seen in older patients is a known risk factor for hypertension and other cardiovascular events as well as chronic kidney disease. Renalase, secreted by the kidney and circulated in blood, may regulate the sympathetic tone by catecholamine degradation and in this way has an impact on cardiovascular and renal complications. OBJECTIVE: To assess the impact of age on renalase and catecholamine concentration in hypertensive patients, including those on dialyses and its possible relation to blood pressure control and cardiovascular disease...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27783636/online-haemodiafiltration-improves-inflammatory-state-in-dialysis-patients-a-longitudinal-study
#8
Ines Rama, Ines Llaudó, Pere Fontova, Gema Cerezo, Carlos Soto, Casimiro Javierre, Miguel Hueso, Nuria Montero, Alberto Martínez-Castelao, Juan Torras, Josep M Grinyó, Josep M Cruzado, Nuria Lloberas
BACKGROUND: Patients undergoing conventional hemodialysis (C-HD) present a greater immuno-inflammatory state probably related to uremia, sympathetic nervous system (SNS) activation and /or membrane bioincompatibility, which could improve with a technique-switching to online hemodiafiltration (OL-HD). The antigen-independent pathway activation of this modified immunologic state turns dendritic cells (DC) into an accurate cell model to study these patients. The aim of this study is to further evaluate the immune-inflammatory state of patients in C-HD assessed by DC maturation...
2016: PloS One
https://www.readbyqxmd.com/read/27778420/urinary-renalase-concentration-in-patients-with-preserved-kidney-function-undergoing-coronary-angiography
#9
Maciej T Wybraniec, Maria Bożentowicz-Wikarek, Jerzy Chudek, Katarzyna Mizia-Stec
AIM: The purpose of the study was to evaluate urinary renalase concentration before and after coronary angiography/percutaneous coronary interventions (CA/PCI) in patients with coronary artery disease (CAD) and preserved kidney function and verify its potential application as contrast-induced acute kidney injury (CI-AKI) diagnostic marker. METHODS: This prospective study comprised 95 consecutive patients (69.5% men; median age 65 years) with CAD submitted to elective or urgent CA/PCI...
October 25, 2016: Nephrology
https://www.readbyqxmd.com/read/27769837/ligand-binding-phenomena-that-pertain-to-the-metabolic-function-of-renalase
#10
Brett A Beaupre, Joseph V Roman, Matthew R Hoag, Kathleen M Meneely, Nicholas R Silvaggi, Audrey L Lamb, Graham R Moran
Renalase catalyzes the oxidation of isomers of β-NAD(P)H that carry the hydride in the 2 or 6 positions of the nicotinamide base to form β-NAD(P)(+). This activity is thought to alleviate inhibition of multiple β-NAD(P)-dependent enzymes of primary and secondary metabolism by these isomers. Here we present evidence for a variety of ligand binding phenomena relevant to the function of renalase. We offer evidence of the potential for primary metabolism inhibition with structures of malate dehydrogenase and lactate dehydrogenase bound to the 6-dihydroNAD isomer...
October 18, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27577995/renalase-secreted-by-human-kidney-hek293t-cells-lacks-its-n-terminal-peptide-implications-for-putative-mechanisms-of-renalase-action
#11
Valerii Fedchenko, Arthur Kopylov, Nadezhda Kozlova, Olga Buneeva, Alexei Kaloshin, Victor Zgoda, Alexei Medvedev
BACKGROUND/AIMS: Renalase is a recently discovered flavoprotein involved in regulation of blood pressure. Altered renalase levels have been found in blood of patients with end stage renal disease. The antihypertensive effect of circulating renalase is attributed to putative FAD-dependent monoamine oxidase activity demonstrated by some authors. Being synthesized as an intracellular flavoprotein renalase requires the presence of its N-terminal peptide for FAD accommodation. However, conventional routes of export of secretory proteins outside the cell usually include cleavage of their N-terminal peptide...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27511639/serum-levels-of-12-renal-function-and-injury-markers-in-patients-with-glomerulonephritis
#12
Natalia M Serwin, Magda Wiśniewska, Anna Jesionowska, Edyta Skwirczyńska, Zuzanna Marcinowska, Barbara Dołęgowska
INTRODUCTION    Glomerulonephritis (GN) is a complex disease that affects the function of the whole nephron. There are few data on the serum levels of the most common biomarkers of kidney function and injury in GN, or the studies provide ambiguous results. OBJECTIVES    The aim of the study was to evaluate the levels of known kidney-specific and nonspecific markers of renal function or injury in the serum of patients with diagnosed primary or secondary GN, with or without the presence of nephrotic syndrome (NS) and arterial hypertension (AH)...
August 9, 2016: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/27508764/-op-6a-01-renalase-in-children-with-glomerular-kidney-diseases
#13
P Skrzypczyk, M Panczyk-Tomaszewska, J Przychodzien, M Mizerska-Wasiak, E Kuzma-Mroczkowska, E Gorska, A Stelmaszczyk-Emmel
OBJECTIVE: Renalase is a protein produced mainly by kidneys. Renalase inactivates circulating catecholamines catalyzing process of their oxidation. Studies in adults with kidney disease suggest that renalase may play a role in pathogenesis of hypertension and target organ damage. The aim of the study was to assess level of renalase in children with glomerular kidney diseases and to find the relation between renalase level and clinical parameters in this group of patients. DESIGN AND METHOD: In 78 children (47 M, 31F) aged from 3...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27507673/polymorphism-of-the-renalase-gene-in-gestational-diabetes-mellitus
#14
Syeda Sadia Fatima, Zehra Jamil, Faiza Alam, Hajira Zafar Malik, Sarosh Irfan Madhani, Muhammad Saad Ahmad, Tayyab Shabbir, Muhammed Noman Rehmani, Amna Rabbani
Renalase is considered as a novel candidate gene for type 2 diabetes. In this study, we aimed to investigate the relationship of serum renalase and two single nucleotide polymorphisms with gestational diabetes mellitus. One hundred and ninety-eight normotensive pregnant females (n = 99 gestational diabetes mellitus; n = 99 euglycemic pregnant controls) were classified according to the International Association of the Diabetes and Pregnancy Study criteria. Fasting and 2-h post glucose load blood levels and anthropometric assessment was performed...
January 2017: Endocrine
https://www.readbyqxmd.com/read/27496485/high-performance-liquid-chromatography-measured-metabolites-of-endogenous-catecholamines-and-their-relations-to-chronic-kidney-disease-and-high-blood-pressure-in-heart-transplant-recipients
#15
G Wasilewski, P Przybylowski, M Wilusz, K Sztefko, Ł Janik, E Koc-Żórawska, J Malyszko
BACKGROUND: Patients after solid organ transplantation, especially heart and kidneys, are prone to be hypertensive. Recently chronic kidney disease and renalase metabolism of endogenous catecholamines are thought to make major contribution to the pathogenesis of hypertension. MATERIALS AND METHODS: We analyzed 75 heart recipients (80% male, 20% female), medium age 54.9 years (range, 25-75) at 0.5 to 22 years after heart transplantation (median, 10.74). Diagnosis of hypertension was made on the basis of ambulatory blood pressure monitoring...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27434211/association-of-renalase-snps-rs2296545-and-rs2576178-with-the-risk-of-hypertension-a-meta-analysis
#16
Yong-Bo Lv, Yang Wang, Wang-Ge Ma, Ding-Yi Yan, Wen-Ling Zheng, Chao Chu, Tong-Shuai Guo, Zu-Yi Yuan, Jian-Jun Mu
BACKGROUND/AIMS: Two renalase single nucleotide polymorphisms (SNPs) rs2296545 and rs2576178 have been reported to be associated with the susceptibility to hypertension (HT). Given the inconsistent results, we conducted a meta-analysis to assess the association between these two SNPs and the risk of HT. METHODS: Electronic databases were systematically searched to find relevant studies. Subgroup analysis was conducted according to the different concomitant diseases and ethnicities in the study population...
2016: PloS One
https://www.readbyqxmd.com/read/27416751/increased-serum-renalase-in-hemodialysis-patients-is-it-related-to-left-ventricular-hypertrophy
#17
Ebru Gok Oguz, Guner Karaveli Gursoy, Ozlem Yayar, Tolga Yildirim, Tolga Cimen, Cengiz Bulut, Barıs Eser, Basol Canbakan, Ekrem Yeter, M Deniz Ayli
INTRODUCTION: Left ventricular hypertrophy (LVH) is one of the most common cardiac abnormalities in patients with end stage renal disease (ESRD). Hypertension, diabetes, increased body mass index, gender, age, anemia, and hyperparathyroidism have been described as risk factors for LVH in patients on dialysis. However, there may be other risk factors which have not been described yet. Recent studies show that renalase is associated with cardiovascular events. The aim of this study was to reveal the relation between renalase, LVH in patients under hemodialysis (HD) treatment...
September 2016: Renal Failure
https://www.readbyqxmd.com/read/27374133/a-remote-role-for-renalase
#18
LETTER
Frank J Giordano, Yang Wang, Gary V Desir
No abstract text is available yet for this article.
July 2016: EBioMedicine
https://www.readbyqxmd.com/read/27333047/limb-ischemic-preconditioning-protects-against-contrast-induced-nephropathy-via-renalase
#19
Feng Wang, Jianyong Yin, Zeyuan Lu, Guangyuan Zhang, Junhui Li, Tao Xing, Shougang Zhuang, Niansong Wang
Clinical trials shows that remote ischemic preconditioning (IPC) can protect against contrast induced nephropathy (CIN) in risky patients, however, the exact mechanism is unclear. In this study, we explored whether renalase, an amine oxidase that has been previously shown to mediate reno-protection by local IPC, would also mediate the same effect elicited by remote IPC in animal model. Limb IPC was performed for 24h followed by induction of CIN. Our results indicated that limb IPC prevented renal function decline, attenuated tubular damage and reduced oxidative stress and inflammation in the kidney...
July 2016: EBioMedicine
https://www.readbyqxmd.com/read/27296286/renalase-a-new-marker-or-just-a-bystander-in-cardiovascular-disease-clinical-and-experimental-data
#20
Dominika Musiałowska, Jolanta Małyszko
No abstract text is available yet for this article.
2016: Kardiologia Polska
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