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Maciej T Wybraniec, Maria Bożentowicz-Wikarek, Jerzy Chudek, Katarzyna Mizia-Stec
AIM: The purpose of the study was to evaluate urinary renalase concentration before and after coronary angiography/percutaneous coronary interventions (CA/PCI) in patients with coronary artery disease (CAD) and preserved kidney function and verify its potential application as contrast-induced acute kidney injury (CI-AKI) diagnostic marker. METHODS: This prospective study comprised 95 consecutive patients (69.5% men; median age 65 years) with CAD submitted to elective or urgent CA/PCI...
October 25, 2016: Nephrology
Brett A Beaupre, Joseph V Roman, Matthew R Hoag, Kathleen M Meneely, Nicholas R Silvaggi, Audrey L Lamb, Graham R Moran
Renalase catalyzes the oxidation of isomers of β-NAD(P)H that carry the hydride in the 2 or 6 positions of the nicotinamide base to form β-NAD(P)(+). This activity is thought to alleviate inhibition of multiple β-NAD(P)-dependent enzymes of primary and secondary metabolism by these isomers. Here we present evidence for a variety of ligand binding phenomena relevant to the function of renalase. We offer evidence of the potential for primary metabolism inhibition with structures of malate dehydrogenase and lactate dehydrogenase bound to the 6-dihydroNAD isomer...
October 18, 2016: Archives of Biochemistry and Biophysics
Valerii Fedchenko, Arthur Kopylov, Nadezhda Kozlova, Olga Buneeva, Alexei Kaloshin, Victor Zgoda, Alexei Medvedev
BACKGROUND/AIMS: Renalase is a recently discovered flavoprotein involved in regulation of blood pressure. Altered renalase levels have been found in blood of patients with end stage renal disease. The antihypertensive effect of circulating renalase is attributed to putative FAD-dependent monoamine oxidase activity demonstrated by some authors. Being synthesized as an intracellular flavoprotein renalase requires the presence of its N-terminal peptide for FAD accommodation. However, conventional routes of export of secretory proteins outside the cell usually include cleavage of their N-terminal peptide...
2016: Kidney & Blood Pressure Research
Natalia M Serwin, Magda Wiśniewska, Anna Jesionowska, Edyta Skwirczyńska, Zuzanna Marcinowska, Barbara Dołęgowska
INTRODUCTION    Glomerulonephritis (GN) is a complex disease that affects the function of the whole nephron. There are few data on the serum levels of the most common biomarkers of kidney function and injury in GN, or the studies provide ambiguous results. OBJECTIVES    The aim of the study was to evaluate the levels of known kidney-specific and nonspecific markers of renal function or injury in the serum of patients with diagnosed primary or secondary GN, with or without the presence of nephrotic syndrome (NS) and arterial hypertension (AH)...
August 9, 2016: Polskie Archiwum Medycyny Wewnętrznej
P Skrzypczyk, M Panczyk-Tomaszewska, J Przychodzien, M Mizerska-Wasiak, E Kuzma-Mroczkowska, E Gorska, A Stelmaszczyk-Emmel
OBJECTIVE: Renalase is a protein produced mainly by kidneys. Renalase inactivates circulating catecholamines catalyzing process of their oxidation. Studies in adults with kidney disease suggest that renalase may play a role in pathogenesis of hypertension and target organ damage. The aim of the study was to assess level of renalase in children with glomerular kidney diseases and to find the relation between renalase level and clinical parameters in this group of patients. DESIGN AND METHOD: In 78 children (47 M, 31F) aged from 3...
September 2016: Journal of Hypertension
Syeda Sadia Fatima, Zehra Jamil, Faiza Alam, Hajira Zafar Malik, Sarosh Irfan Madhani, Muhammad Saad Ahmad, Tayyab Shabbir, Muhammed Noman Rehmani, Amna Rabbani
Renalase is considered as a novel candidate gene for type 2 diabetes. In this study, we aimed to investigate the relationship of serum renalase and two single nucleotide polymorphisms with gestational diabetes mellitus. One hundred and ninety-eight normotensive pregnant females (n = 99 gestational diabetes mellitus; n = 99 euglycemic pregnant controls) were classified according to the International Association of the Diabetes and Pregnancy Study criteria. Fasting and 2-h post glucose load blood levels and anthropometric assessment was performed...
August 9, 2016: Endocrine
G Wasilewski, P Przybylowski, M Wilusz, K Sztefko, Ł Janik, E Koc-Żórawska, J Malyszko
BACKGROUND: Patients after solid organ transplantation, especially heart and kidneys, are prone to be hypertensive. Recently chronic kidney disease and renalase metabolism of endogenous catecholamines are thought to make major contribution to the pathogenesis of hypertension. MATERIALS AND METHODS: We analyzed 75 heart recipients (80% male, 20% female), medium age 54.9 years (range, 25-75) at 0.5 to 22 years after heart transplantation (median, 10.74). Diagnosis of hypertension was made on the basis of ambulatory blood pressure monitoring...
June 2016: Transplantation Proceedings
Yong-Bo Lv, Yang Wang, Wang-Ge Ma, Ding-Yi Yan, Wen-Ling Zheng, Chao Chu, Tong-Shuai Guo, Zu-Yi Yuan, Jian-Jun Mu
BACKGROUND/AIMS: Two renalase single nucleotide polymorphisms (SNPs) rs2296545 and rs2576178 have been reported to be associated with the susceptibility to hypertension (HT). Given the inconsistent results, we conducted a meta-analysis to assess the association between these two SNPs and the risk of HT. METHODS: Electronic databases were systematically searched to find relevant studies. Subgroup analysis was conducted according to the different concomitant diseases and ethnicities in the study population...
2016: PloS One
Ebru Gok Oguz, Guner Karaveli Gursoy, Ozlem Yayar, Tolga Yildirim, Tolga Cimen, Cengiz Bulut, Barıs Eser, Basol Canbakan, Ekrem Yeter, M Deniz Ayli
INTRODUCTION: Left ventricular hypertrophy (LVH) is one of the most common cardiac abnormalities in patients with end stage renal disease (ESRD). Hypertension, diabetes, increased body mass index, gender, age, anemia, and hyperparathyroidism have been described as risk factors for LVH in patients on dialysis. However, there may be other risk factors which have not been described yet. Recent studies show that renalase is associated with cardiovascular events. The aim of this study was to reveal the relation between renalase, LVH in patients under hemodialysis (HD) treatment...
September 2016: Renal Failure
Frank J Giordano, Yang Wang, Gary V Desir
No abstract text is available yet for this article.
July 2016: EBioMedicine
Feng Wang, Jianyong Yin, Zeyuan Lu, Guangyuan Zhang, Junhui Li, Tao Xing, Shougang Zhuang, Niansong Wang
Clinical trials shows that remote ischemic preconditioning (IPC) can protect against contrast induced nephropathy (CIN) in risky patients, however, the exact mechanism is unclear. In this study, we explored whether renalase, an amine oxidase that has been previously shown to mediate reno-protection by local IPC, would also mediate the same effect elicited by remote IPC in animal model. Limb IPC was performed for 24h followed by induction of CIN. Our results indicated that limb IPC prevented renal function decline, attenuated tubular damage and reduced oxidative stress and inflammation in the kidney...
July 2016: EBioMedicine
Dominika Musiałowska, Jolanta Małyszko
No abstract text is available yet for this article.
2016: Kardiologia Polska
Lindsay Hollander, Xiaojia Guo, Heino Velazquez, John Chang, Robert Safirstein, Harriet Kluger, Charles Cha, Gary V Desir
To sustain their proliferation, cancer cells overcome negative-acting signals that restrain their growth and promote senescence and cell death. Renalase (RNLS) is a secreted flavoprotein that functions as a survival factor after ischemic and toxic injury, signaling through the plasma calcium channel PMCA4b to activate the PI3K/AKT and MAPK pathways. We show that RNLS expression is increased markedly in primary melanomas and CD163(+) tumor-associated macrophages (TAM). In clinical specimens, RNLS expression in the tumor correlated inversely with disease-specific survival, suggesting a pathogenic role for RNLS...
July 1, 2016: Cancer Research
Maciej T Wybraniec, Katarzyna Mizia-Stec
BACKGROUND: Contrast-induced acute kidney injury (CI-AKI) remains one of the crucial issues related to the development of invasive cardiology. The massive use of contrast media exposes patients to a great risk of contrast-induced nephropathy and chronic kidney disease development, and increases morbidity and mortality rates. The serum creatinine concentration does not allow for a timely and accurate CI-AKI diagnosis; hence numerous other biomarkers of renal injury have been proposed. Renalase, a novel catecholamine-metabolizing amine oxidase, is synthesized mainly in proximal tubular cells and secreted into urine and blood...
December 2015: Cardiorenal Medicine
Binnur Bagci, Savas Karakus, Gokhan Bagci, Enver Sancakdar
BACKGROUND: Renalase is a novel enzyme that degrades circulating catecholamines. We aimed to investigate the role of rs2576178 and rs10887800 polymorphisms of the renalase gene in preeclampsia (PE) patients METHODS: This case-control study consisted of 110 women with PE and 102 normotensive controls. PCR-RFLP method was used for determination of renalase gene polymorphisms. RESULTS: Allele frequency and genotype distribution of rs10887800 polymorphism were found statistically significantly higher in women with PE (p<0...
April 2016: Pregnancy Hypertension
Zehra Vural Yılmaz, Elif Akkaş, Tolga Yıldırım, Rahmi Yılmaz, Yunus Erdem
Background Preeclampsia is characterized by a increase in high blood pressure and decrease in GFR and proteinuria, however, the underlying mechanisms are still unclear. Renalase is a recently discovered protein implicated in regulation of blood pressure in humans. Materials and Methods Plasma concentrations of serum renalase were measured in healthy controls, healthy pregnant and pregnant with preeclampsia matched for age, gestational age, in the third trimester of pregnancy. Serum renalase levels were compared in pregnant with and without preeclampsia and non-pregnant controls...
May 4, 2016: Journal of Maternal-fetal & Neonatal Medicine
Anna Stec, Andrzej Ksiazek, Monika Buraczynska
PURPOSE: Coronary artery disease (CAD) is common in patients with end-stage renal disease (ESRD). Recent studies have suggested that renalase, a novel FAD-dependent amine oxidase, may play an important role in the pathogenesis of cardiovascular complications in ESRD patients. The aim of the study was to investigate the association between renalase gene polymorphisms and a risk of CAD in patients on hemodialysis. METHODS: In a case-control study, a total of 309 hemodialyzed patients (107 with and 202 without CAD) were genotyped for two SNPs in the renalase gene (rs10887800 and rs2576178) using the PCR-RFLP method...
June 2016: International Urology and Nephrology
Emina Kiseljakovic, Mirela Mackic-Djurovic, Sabaheta Hasic, Amela Beciragic, Amina Valjevac, Lejla Alic, Halima Resic
INTRODUCTION: Renalase is a protein secreted in kidneys and considered as a blood pressure modulator. High rates of hypertension and its regulation in patients on hemodialysis demands search for potential cause and treatment. The aim of this study was to determine the genotype and allele frequencies of renalase gene rs2576178 polymorphism in population from Bosnia and Herzegovina. Also, the objective of present study was to find the possible association between renalase gene rs2576178 polymorphism and hypertension in patients on hemodialysis...
February 2016: Medical Archives
Xiaojia Guo, Lindsay Hollander, Douglas MacPherson, Ling Wang, Heino Velazquez, John Chang, Robert Safirstein, Charles Cha, Fred Gorelick, Gary V Desir
An essential feature of cancer is dysregulation of cell senescence and death. Renalase, a recently discovered secreted flavoprotein, provides cytoprotection against ischemic and toxic cellular injury by signaling through the PI3K-AKT and MAPK pathways. Here we show that renalase expression is increased in pancreatic cancer tissue and that it functions as a growth factor. In a cohort of patients with pancreatic ductal adenocarcinoma, overall survival was inversely correlated with renalase expression in the tumor mass, suggesting a pathogenic role for renalase...
2016: Scientific Reports
Jianyong Yin, Zeyuan Lu, Feng Wang, Zhenzhen Jiang, Limin Lu, Naijun Miao, Niansong Wang
Chronic kidney disease is associated with higher risk of cardiovascular complication and this interaction can lead to accelerated dysfunction in both organs. Renalase, a kidney-derived cytokine, not only protects against various renal diseases but also exerts cardio-protective effects. Here, we investigated the role of renalase in the progression of cardiorenal syndrome (CRS) after subtotal nephrectomy. Sprague-Dawley rats were randomly subjected to sham operation or subtotal (5/6) nephrectomy (STNx). Two weeks after surgery, sham rats were intravenously injected with Hanks' balanced salt solution (sham), and STNx rats were randomly intravenously injected with adenovirus-β-gal (STNx+Ad-β-gal) or adenovirus-renalase (STNx+Ad-renalase) respectively...
June 2016: Journal of Cellular and Molecular Medicine
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