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amniotic fluid measurements

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https://www.readbyqxmd.com/read/28708576/adiponectin-concentration-in-mid-trimester-amniotic-fluid-varies-with-the-%C3%AE-amylase-level-and-maternal-and-neonatal-outcomes
#1
Joseph Chervenak, Mio Sawai, Lamis El Kabab, Rahul Lohana, Daniel Skupski, Steven S Witkin
OBJECTIVE: Factors influencing intraamniotic adiponectin levels and their functional significance remain incompletely elucidated. We prospectively measured adiponectin in amniotic fluid and identified its associations with maternal parameters, mediators in amniotic fluid and pregnancy outcomes. STUDY DESIGN: Mid-trimester amniotic fluid from 571 women was tested for adiponectin, interleukin (IL)-6, IL-8 and α-amylase by enzyme-linked immunosorbant assay (ELISA), after which clinical data were obtained...
July 14, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28708036/amniotic-fluid-cells-show-higher-pluripotency-related-gene-expression-than-allantoic-fluid-cells
#2
Debora Kehl, Melanie Generali, Sabrina Görtz, Diego Geering, Jaroslav Slamecka, Simon P Hoerstrup, Ulrich Bleul, Benedikt Weber
Amniotic fluid represents an abundant source of multipotent stem cells, referred as broadly mul-tipotent given their differentiation potential and expression of pluripotency-related genes. How-ever, the origin of this broadly multipotent cellular fraction is not fully understood. Several sources have been proposed so far, including embryonic and extra-embryonic tissues. In this re-gard, the ovine developmental model uniquely allows for direct comparison of fetal fluid-derived cells from two separate fetal fluid cavities, the allantois and the amnion, over the entire duration of gestation...
July 14, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28705923/maternal-and-female-fetal-testosterone-levels-are-associated-with-maternal-age-and-gestational-weight-gain
#3
Theodora Kunovac-Kallak, Charlotte Hellgren, Alkistis Skalkidou, Lotta Sandelin-Francke, Kumari Ubhayasekera, Jonas Bergquist, Ove Axelsson, Erika Comasco, Rebecca Campbell, Inger Sundstrom Poromaa
OBJECTIVE: Prenatal androgen exposure has been suggested to play a role in polycystic ovary syndrome. Given the limited information on what maternal characteristics influence maternal testosterone levels, and the even less explored routes by which female fetus androgen exposure would occur, the aim of this study was to investigate the impact of maternal age, BMI, weight gain, depressed mood, and aromatase SNPs on testosterone levels in maternal serum and amniotic fluid of female fetuses...
July 13, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28693352/transvaginal-sonographic-assessment-of-cervix-in-prediction-of-admission-to-delivery-interval-in-preterm-premature-rupture-of-membranes
#4
Vimala Kathir, Dilip Maurya, Anish Keepanasseril
OBJECTIVE: To assess the usefulness of cervical parameters measured by transvaginal sonography, ie cervical length and posterior cervical angle, in predicting the admission to delivery interval in women with preterm rupture of membranes. METHODS: This prospective study was conducted in a tertiary care centre in South India. Women with preterm premature rupture of membranes at 28-34 weeks, confirmed clinically, not in labour and presenting within 24 hours to hospital were included...
July 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28691546/procalcitonin-in-amniotic-fluid-at-the-time-of-genetic-amniocentesis-and-preterm-delivery
#5
Robyn T Bilinski, Shauna F Williams, Joseph J Apuzzio
PURPOSE: Procalcitonin (PCT) is an acute phase protein that has been infrequently studied in amniotic fluid. We sought to determine if PCT levels measured in amniotic fluid samples at the time of genetic amniocentesis are predictive of preterm delivery. MATERIALS AND METHODS: A retrospective cohort study was performed on all women presenting for genetic amniocentesis between 15-23 weeks of pregnancy at our institution from 2011 to 2013 with stored amniotic fluid samples...
July 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28663113/pregnancy-exposure-to-citalopram-therapeutic-drug-monitoring-in-maternal-blood-amniotic-fluid-and-cord-blood
#6
Michael Paulzen, Tamme W Goecke, Julia C Stingl, Geer Janssen, Elmar Stickeler, Gerhard Gründer, Georgios Schoretsanitis
RATIONALE: Aim of the study was to measure and correlate citalopram concentrations in maternal blood, amniotic fluid and umbilical cord blood to account for the distribution of the drug between these three compartments. METHODS: Concentrations of citalopram were measured in twelve mother infant pairs at the time of delivery. Data are provided as median values, first (Q1) and third (Q3) quartiles as well as ranges. To account for the penetration ratio into amniotic fluid and cord blood, the concentration of citalopram in was divided by the concentration in maternal serum...
June 27, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28651682/the-wuhan-twin-birth-cohort-wtbc
#7
Jinzhu Zhao, Shaoping Yang, Anna Peng, Zhengmin Qian, Hong Xian, Tianjiao Chen, Guanghui Dong, Yiming Zhang, Xijiang Hu, Zhong Chen, Jiangxia Cao, Xiaojie Song, Shunqing Xu, Tongzhang Zheng, Bin Zhang
The Wuhan Pre/Post-Natal Twin Birth Registry (WPTBR) is one of the largest twin birth registries with comprehensive medical information in China. It recruits women from the first trimester of pregnancy and their twins from birth. From January 2006 to May 2016, the total number of twins enrolled in WPTBR is 13,869 twin pairs (27,553 individuals). The WPTBR initiated the Wuhan Twin Birth Cohort (WTBC). The WTBC is a prospective cohort study carried out through incorporation of three samples. The first one comprises 6,920 twin pairs, and the second one, 6,949 twin pairs...
August 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28651466/levels-of-multiple-proteins-in-gingival-crevicular-fluid-and-intra-amniotic-complications-in-women-with-preterm-prelabor-rupture-of-membranes
#8
Marian Kacerovsky, Vladimira Radochova, Ivana Musilova, Martin Stepan, Radovan Slezak, Ctirad Andrys, Kristin Skogstrand, David Hougaard, Bo Jacobsson
OBJECTIVE: The primary aim of this study was to identify the association between the local inflammatory response in gingival crevicular fluid measured by the levels of multiple proteins and maternal and intra-amniotic inflammatory responses measured by maternal serum C-reactive protein (CRP) and amniotic fluid interleukin (IL)-6 concentrations, respectively, in women with preterm prelabor rupture of membranes (PPROM). METHODS: A prospective study was performed in which 78 women with singleton pregnancies complicated by PPROM between 24+0 and 36+6 weeks of gestation were included...
June 26, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28569215/diagnosis-of-swine-toxoplasmosis-by-pcr-and-genotyping-of-toxoplasma-gondii-from-pigs-in-henan-central-china
#9
Haiyan Wang, Longxian Zhang, Qinge Ren, Fuchang Yu, Yurong Yang
BACKGROUND: Toxoplasma gondii, a widely prevalent protozoan parasite, causes serious toxoplasmosis infections in humans and other animals. Among livestock, pigs are susceptible to T. gondii infection. Despite Henan being one of the biggest pig-raising provinces in China, little information exists on the epidemiology of toxoplasmosis in this location. Therefore, we molecularly characterized DNA samples from pigs in Henan. A total of 1647 samples, including 952 from dead piglets, 478 from seriously sick fattening pigs and 217 from abortion sows, were collected from different animal hospitals or pig farms from 10 different cities in Henan (2006-2008)...
May 31, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28556937/abnormal-fetal-findings-associated-with-a-global-sphericity-index-of-the-4-chamber-view-below-the-5th-centile
#10
Greggory R DeVore, Gary Satou, Mark Sklansky
OBJECTIVES: The purpose of this study was to evaluate the global sphericity index (GSI) of the 4-chamber view and correlate the results with abnormal ultrasound findings. METHODS: The epicardial end-diastolic basal-apical length (BAL) and transverse length (TL) of the 4-chamber view were measured to compute the GSI (BAL/TL) in 200 control fetuses between 20 and 40 weeks' gestation. Three hundred study fetuses were prospectively examined between 17 and 39 weeks' gestation...
May 30, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28549467/the-prediction-diagnosis-and-management-of-complications-in-monochorionic-twin-pregnancies-the-ommit-optimal-management-of-monochorionic-twins-study
#11
Fiona L Mackie, R Katie Morris, Mark D Kilby
BACKGROUND: Monochorionic twin pregnancies are at increased risk of complications due to sharing a single placenta and potentially developing unbalanced vascular anastomoses. Complications include twin-twin transfusion syndrome (TTTS) which affects 10-15% monochorionic twins, and if untreated has a 70-90% perinatal loss rate. We are currently unable to predict which twins will develop complications or to what severity. We have previously shown differences in angiogenic and placental growth factors in maternal blood in pregnancies complicated by TTTS compared to twin pregnancies not complicated by TTTS but matched for gestation...
May 26, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28545116/n-terminal-pro-b-type-natriuretic-peptide-in-amniotic-fluid-of-fetuses-with-known-or-suspected-cardiac-load
#12
Christina Leufgen, Ulrich Gembruch, Birgit Stoffel-Wagner, Rolf Fimmers, Waltraut M Merz
BACKGROUND: Myocardial dysfunction occurs in a variety of fetal disorders. Findings from adult cardiology, where n-terminal pro-B-type natriuretic peptide (nt-proBNP) is an established biomarker of left ventricular dysfunction have been extended to fetal life. Since fetal blood sampling is technically challenging we investigated amniotic fluid nt-proBNP for its suitability to diagnose fetal myocardial dysfunction. METHODS: Ultrasound, Doppler examination and echocardiography was applied to classify cases and controls...
2017: PloS One
https://www.readbyqxmd.com/read/28535541/contribution-of-amniotic-fluid-along-gestation-to-the-prediction-of-perinatal-mortality-in-women-with-early-preterm-premature-rupture-of-membranes
#13
Teresa Cobo, Jordina Munrós, José Ríos, Janisse Ferreri, Federico Migliorelli, Núria Baños, Eduard Gratacós, Montse Palacio
INTRODUCTION: To evaluate the largest vertical pocket (LVP) of amniotic fluid as a time-dependent factor to predict perinatal mortality in women with early preterm premature rupture of membranes (EPPROM). MATERIAL AND METHODS: Observational cohort study of singleton pregnancies with EPPROM <24 weeks. Termination of pregnancy (TOP) was considered if the LVP was <2 cm at 7 days. The maternal and neonatal characteristics of ongoing pregnancies were recorded. Prediction of perinatal mortality was estimated based on the influence of the LVP as a time-dependent factor after adjustment for maternal age, prior invasive procedure, and gestational age at EPPROM...
May 24, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28503847/addition-of-color-doppler-sonography-for-detection-of-amniotic-fluid-disturbances-and-its-implications-on-perinatal-outcomes
#14
Imelda N Odibo, Brianna S Whittemore, Dawn S Hughes, Pamela M Simmons, Songthip T Ounpraseuth, Everett F Magann
OBJECTIVES: To determine whether color Doppler sonography increases the detection of pregnancies at risk for adverse outcomes. METHODS: Participants admitted to labor and delivery with the anticipation of a vaginal delivery underwent measurements of amniotic fluid volume (AFV) using amniotic fluid index (AFI) and single deepest pocket (SDP) techniques by grayscale followed by color Doppler sonography. Oligohydramnios was defined as an AFI of less than 5 cm or an SDP of less than 2 cm...
May 15, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28503779/normal-amniotic-fluid-volume-across-gestation-comparison-of-statistical-approaches-in-1190-normal-amniotic-fluid-volumes
#15
Songthip T Ounpraseuth, Everett F Magann, Horace J Spencer, Nader Z Rabie, Adam T Sandlin
AIM: Ultrasound estimation and evaluation of amniotic fluid volume (AFV) is an important component of pregnancy surveillance and fetal well-being. The purpose of this study was to compare and contrast four statistical methods used to construct gestational age-specific reference intervals for the assessment of AFV. METHODS: A total of 1095 normal AFV derived from four studies that measured AFV using dye-dilution or direct measurement at the time of hysterotomy were used to construct reference intervals using polynomial regression, quantile regression, Royston and Wright mean and SD, and Cole's lambda mu sigma (LMS) methods...
May 15, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28502201/prediction-of-chorioamnionitis-in-cases-of-intraamniotic-infection-by-ureaplasma-urealyticum-in-women-with-very-preterm-premature-rupture-of-membranes-or-preterm-labour
#16
Rocio Revello, María José Alcaide, Daniel Abehsera, María Martin-Camean, Mafalda Sousa E Faro Gomes, Bárbara Alonso-Luque, Jose L Bartha
OBJECTIVES: First, to determinate the frequency of chorioamnionitis and funisitis in cases of intramniotic detection of Ureaplasma urealyticum. Second, to assess the predictive capability of some biological markers in the amniotic fluid of these women to predict histological inflammation. SUBJECTS AND METHODS: We prospectively studied 20 cases of women with premature rupture of membranes or preterm labour (PROM) or preterm labour and intraamniotic detection of Ureaplasma urealyticum...
June 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28469527/histologic-chorioamnionitis-amniotic-fluid-interleukin-6-krebs-von-den-lungen-6-and-transforming-growth-factor-%C3%AE-1-for-the-development-of-neonatal-bronchopulmonary-dysplasia
#17
Hisako Matsumura, Hiroyuki Ichiba, Satoshi Ohnishi, Mika Saito, Haruo Shintaku
BACKGROUND: Chorioamnionitis (CAM) is an important risk factor for the development of bronchopulmonary dysplasia (BPD) in preterm infants. OBJECTIVES: To evaluate the effects of CAM on the development of BPD using interleukin 6 (IL-6), Krebs von den Lungen 6 (KL-6), and transforming growth factor β1 (TGF-β1) in the amniotic fluid as markers for inflammation, lung injury, and fibrosis/remodeling, respectively. METHODS: Amniotic fluid concentrations of IL-6, KL-6, and TGF-β1 were measured with enzyme-linked immunosorbent assay or electro-chemiluminescence immunoassay...
2017: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/28455084/recipient-umbilical-artery-elongation-redundancy-in-twin-twin-transfusion-syndrome
#18
Roopali Donepudi, Lovepreet K Mann, Christoph Wohlmuth, Anthony Johnson, Michael W Bebbington, Kenneth J Moise, David S Boudreaux, Helena Gardiner, Ramesha Papanna
BACKGROUND: Chronic hypertension in adults causes arterial lengthening in major arteries, but the effects of early fetal hypertension on the twin-twin transfusion syndrome recipient's vascular architecture remains unknown. OBJECTIVE: We hypothesize that arterial cord redundancy is related to recipient hypertension and subsequent heart failure. Our objectives were to: (1) establish a 3-dimensional color Doppler ultrasound method of measuring umbilical arterial length relative to its corresponding venous segment in the umbilical cord using artery vein angle; (2) compare recipient artery vein angle to gestational age-matched controls; and (3) test the association of artery vein angle with recipient heart failure...
April 25, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28358839/frequency-and-clinical-significance-of-short-cervix-in-patients-with-preterm-premature-rupture-of-membranes
#19
Seung Mi Lee, Kyo Hoon Park, Eun Young Jung, Ji Ae Jang, Ha-Na Yoo
OBJECTIVE: Cervical length measurement has been uggested as a useful tool for predicting intra-amniotic infection/inflammation in preterm labor, but little information is available in the setting of preterm premature rupture of membranes (pPROM). We aimed to determine whether a short cervical length is independently associated with an increased risk of intra-amniotic infection or inflammation and impending preterm delivery in women with pPROM. METHODS: This was a retrospective cohort study involving 171 consecutive singleton pregnant women with pPROM (21+0-33+6 weeks' gestation), who underwent amniocentesis...
2017: PloS One
https://www.readbyqxmd.com/read/28347187/second-trimester-amniotic-fluid-corticotropin-releasing-hormone-and-urocortin-in-relation-to-maternal-stress-and-fetal-growth-in-human-pregnancy
#20
Pearl La Marca-Ghaemmaghami, Sara M Dainese, Günter Stalla, Marina Haller, Roland Zimmermann, Ulrike Ehlert
This study explored the association between the acute psychobiological stress response, chronic social overload and amniotic fluid corticotropin-releasing hormone (CRH) and urocortin (UCN) in 34 healthy, second-trimester pregnant women undergoing amniocentesis. The study further examined the predictive value of second-trimester amniotic fluid CRH and UCN for fetal growth and neonatal birth outcome. The amniocentesis served as a naturalistic stressor, during which maternal state anxiety and salivary cortisol was measured repeatedly and an aliquot of amniotic fluid was collected...
April 21, 2017: Stress: the International Journal on the Biology of Stress
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