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Langlang Ma, Min Liu, Yuanyuan Yan, Chunyan Qing, Xiaoling Zhang, Yanling Zhang, Yun Long, Lei Wang, Lang Pan, Chaoying Zou, Zhaoling Li, Yanli Wang, Huanwei Peng, Guangtang Pan, Zhou Jiang, Yaou Shen
The regenerative capacity of the embryonic callus, a complex quantitative trait, is one of the main limiting factors for maize transformation. This trait was decomposed into five traits, namely, green callus rate (GCR), callus differentiating rate (CDR), callus plantlet number (CPN), callus rooting rate (CRR), and callus browning rate (CBR). To dissect the genetic foundation of maize transformation, in this study multi-locus genome-wide association studies (GWAS) for the five traits were performed in a population of 144 inbred lines genotyped with 43,427 SNPs...
2018: Frontiers in Plant Science
Atef M Al-Attar, Moustafa H R Elnaggar, Essam A Almalki
The present study was aimed to evaluate the influence of olive, sesame and black seed oils on levels of some physiological parameters in male rats exposed to diazinon (DZN). Body weight changes, and levels of serum total protein, albumin, glucose, triglycerides, cholesterol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), atherogenic index (AI), atherogenic coefficient (AC), cardiac risk ratio (CRR), glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MAD) were selected as physiological parameters...
May 2018: Saudi Journal of Biological Sciences
Takayuki Ueno, Norikazu Masuda, Shunji Kamigaki, Takashi Morimoto, Futoshi Akiyama, Masafumi Kurosumi, Hitoshi Tsuda, Yoshiki Mikami, Sunao Tanaka, Satoshi Morita, Masakazu Toi
Neoadjuvant endocrine therapy has been reported to decrease tumor size, which leads to increased breast conservation rates. To improve the clinical response, metronomic chemotherapy with endocrine therapy is a promising strategy. A multicenter phase II single-arm neoadjuvant trial with letrozole and cyclophosphamide was conducted. Eligibility criteria included postmenopausal status, T2-4 N0-1, and estrogen receptor-positive breast carcinoma. Letrozole (2.5 mg) plus cyclophosphamide (50 mg) was given orally once a day for 24 weeks...
May 7, 2018: Cancer Medicine
Arunagiri Kamala, Sushil Kumar Middha, Chitra Gopinath, H S Sindhura, Chandrakant S Karigar
Background: Cyperus rotundus L. (family Cyperaceae), native to India, is a multivalent medicinal plant widely used in conventional medicine. The research reports on bioactive components from C. rotundus L. are scanty. Objective: The objective of the study was to optimize the best solvent system and bioprospect the possible phytochemicals in C. rotundus L. rhizome (CRR). Materials and Methods: The phytochemicals were extracted from the rhizomes of C...
April 2018: Pharmacognosy Magazine
Michele Marchioni, Sabrina S Harmouch, Sebastiano Nazzani, Marco Bandini, Felix Preisser, Zhe Tian, Anil Kapoor, Luca Cindolo, Alberto Briganti, Shahrokh F Shariat, Luigi Schips, Pierre I Karakiewicz
AIM: To test the effect of African-American race on cancer specific mortality (CSM) in clear cell metastatic renal cell carcinoma (ccmRCC) and non-ccmRCC. PATIENTS AND METHODS: Within Surveillance, Epidemiology and End Results registry (2001-2014), we identified patients with ccmRCC and non-ccmRCC. We relied on propensity score (PS) matching to reduce the effect of inherent differences between African-American vs. Caucasian patients. After PS matching that included access to cytoreductive nephrectomy (CNT), cumulative incidence, competing-risks regression (CRR) models and landmark analyses tested the effect of race on CSM...
April 28, 2018: Cancer Epidemiology
Peng Lin, Wei Wang, Wei-Bo Huang, Ming-Wei Li, Xiao-Na Yang, Hai-Ying Yao
OBJECTIVE: To compare the complete remission rate (CRR) and adverse reaction of the 3 different chemotherapy regimens (daunorubicin, idarubicin, imported idarubicin combined with cytarabine) for the treatment of adult patients with newly diagnosed non-M3 acute myeloid leukemia (AML). METHODS: Seventy-one adult patients with newly diagnosed non-M3 AML were divided into 3 groups: 17 cases treated with daunorubicin plus cytarabine as group A, 24 cases treated with idarubicin plus cytarabine as group B, 30 cases treated with the imported idarubicin plus cytarabine as group C...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
Raisa S Pompe, Derya Tilki, Felix Preisser, Sami-Ramzi Leyh-Bannurah, Marco Bandini, Michele Marchioni, Philipp Gild, Zhe Tian, Nicola Fossati, Luca Cindolo, Shahrokh F Shariat, Hartwig Huland, Markus Graefen, Alberto Briganti, Pierre I Karakiewicz
BACKGROUND: To test whether local treatment (LT), namely radical prostatectomy (RP) or brachytherapy (BT) still confers a survival benefit versus no local treatment (NLT), when adjusted for baseline PSA (bPSA). To further examine whether the effect of LT might be modulated according to bPSA and M1 substages. METHODS: Of 13 906 mPCa patients within the SEER (2004-2014), 375 underwent RP, 175 BT, and 13 356 NLT. Multivariable competing risks regression (MVA CRR) analyses after 1:2 propensity score matching assessed the impact of LT versus NLT on cancer specific mortality (CSM)...
April 16, 2018: Prostate
Richard C Rogers, David H McDougal, Sue Ritter, Emily Qualls-Creekmore, Gerlinda E Hermann
Hindbrain catecholamine (CA) neurons are required for critical autonomic, endocrine, and behavioral counter-regulatory responses (CRRs) to hypoglycemia. Recent studies suggest that CRR initiation depends on hindbrain astrocyte glucose sensors (39, 64). To test the proposition that hindbrain CA responses to glucoprivation are astrocyte dependent, we utilized transgenic mice in which the calcium reporter construct (GCaMP5) was expressed selectively in tyrosine hydroxylase neurons (TH-GCaMP5). We conducted live-cell calcium imaging studies on tissue slices containing the nucleus of the solitary tract (NST) or the ventrolateral medulla (VLM); critical CRR initiation sites...
March 28, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Ling-Ling Zhang, Li-Nong Yao, Hua-Liang Chen, Qiao-Yi Lu, Wei Ruan
BACKGROUND: Plasmodium vivax remains a potential cause of morbidity and mortality for people living where it is endemic. Understanding the regional genetic diversity of P. vivax is valuable for studying population dynamics and tracing the origins of parasites. The Plasmodium vivax circumsporozoite gene (PvCSP) is highly polymorphic and has been used previously as a marker in P. vivax population studies. The aim of this study is to investigate the genetic diversity of the PvCSP, to provide more genetic polymorphism data for further studies on P...
May 2018: Experimental Parasitology
Weihui Xu, Yimin You, Zhigang Wang, Wenjing Chen, Jin Zeng, Xiaosong Zhao, Yunpeng Su
Dibutyl phthalate (DBP) is well known as a high-priority pollutant. This study explored the impacts of DBP on the metabolic pathways of microbes in black soils in the short term (20 days). The results showed that the microbial communities were changed in black soils with DBP. In nitrogen cycling, the abundances of the genes were elevated by DBP. DBP contamination facilitated 3'-phosphoadenosine-5'-phosphosulfate (PAPS) formation, and the gene flux of sulfate metabolism was increased. The total abundances of ABC transporters and the gene abundances of the monosaccharide-transporting ATPases MalK and MsmK were increased by DBP...
February 8, 2018: Scientific Reports
Hui Wang, Jing-Xiao Zhang, Yue Wang, Wen-Hong Fang, Yuan Wang, Jun-Fang Zhou, Shu Zhao, Xin-Cang Li
Type II crustins are the most abundant type of crustins in shrimps that exhibit remarkable sequence diversities and broad antibacterial activities. This study characterized a novel type II crustin, SpCrus2, in the mud crab Scylla paramamosain. The SpCrus2 cDNA sequence is 620-bp long with a 495-bp open reading frame encoding a 164-amino acid protein. In the deduced protein, a 17-amino acid signal peptide, a glycine-rich hydrophobic region (GRR), and a cysteine-rich region (CRR) containing a whey acidic protein domain were predicted...
July 2018: Developmental and Comparative Immunology
Sam A O'Connor, Trevor N Brooklyn, Paul D Dunckley, Roland M Valori, Ruth Carr, Chris Foy, Thusitha Somarathna, Lukasz A Adamczyk, Neil A Shepherd, John T Anderson
Background and study aims:  The majority of polyps removed at colonoscopy are diminutive (≤ 5 mm) to small (< 10 mm) and there are few guidelines for the best way for these polyps to be removed. We aimed to assess the feasibility and effectiveness of cold biopsy forceps polypectomy with pre-lift (CBPP) for polyps ≤ 7 mm. Our aims were to assess completeness of histological resection of this technique, to identify factors contributing to this and assess secondary considerations such as timing, retrieval and complication rates...
February 2018: Endoscopy International Open
Michele Marchioni, Felix Preisser, Marco Bandini, Sebastiano Nazzani, Zhe Tian, Anil Kapoor, Luca Cindolo, Firas Abdollah, Derya Tilki, Alberto Briganti, Francesco Montorsi, Shahrokh F Shariat, Luigi Schips, Pierre I Karakiewicz
BACKGROUND: Historically, partial nephrectomy (PN) showed no benefit on other-cause mortality (OCM) in elderly patients with small renal masses. OBJECTIVE: To test the effect of PN versus radical nephrectomy (RN) on OCM, cancer-specific mortality (CSM), as well as 30-d mortality in patients with nonmetastatic T1a renal cell carcinoma (RCC), aged ≥75 yr old. DESIGN, SETTING, AND PARTICIPANTS: Within the Surveillance, Epidemiology and End Results registry (2004-2014), we identified surgically treated patients with nonmetastatic pT1a RCC aged ≥75 yr...
February 2, 2018: European Urology Focus
Young Duck Shin, Young Jin Choi, Dae Hoon Kim, Sung Su Park, Hanlim Choi, Dong Ju Kim, Sungmin Park, Hyo Yung Yun, Young Jin Song
This study aimed to determine the efficacy of intraoperative ultrasonography-guided wire localization guided breast-conserving surgery (BCS) for nonpalpable breast cancer and compare it to conventional preoperative wire localization (PWL) guided surgery.We retrospectively analyzed the medical charts of 214 consecutive nonpalpable breast cancer patients who underwent BCS using intraoperative ultrasonography-guided wire localization by a surgeon (IUWLS) and PWL, between April 2013 and March 2017. Positive surgical margins, reexcision rates, and resection volumes were investigated...
December 2017: Medicine (Baltimore)
Su Jung Han, Yunho Jung, Young Sin Cho, Il-Kwun Chung, Jae Yun Kim, Jun Young Eun, Seoung Ho Lee, Gyu Bong Ko, Tae Hoon Lee, Sang Hum Park, Hyun Deuk Cho, Sun-Joo Kim
BACKGROUND/AIMS: Submucosal injection with indigo carmine mixed solution can improve the delineation of colorectal neoplasia during endoscopic mucosal resection (EMR). Thus, the aim of this study was to evaluate the efficacy of submucosal injection with indigo carmine mixed solution during EMR of colorectal neoplasia. METHODS: This was a prospective, randomized, controlled study of a total of 212 neoplastic colon polyps (5-20 mm) subjected to EMR in a single tertiary university hospital...
March 2018: Digestive Diseases and Sciences
Marco Bandini, Felix Preisser, Sebastiano Nazzani, Michele Marchioni, Zhe Tian, Nicola Fossati, Giorgio Gandaglia, Andrea Gallina, Firas Abdollah, Shahrokh F Shariat, Francesco Montorsi, Fred Saad, Derya Tilki, Alberto Briganti, Pierre I Karakiewicz
BACKGROUND: Aborted radical prostatectomy (aRP) in lymph node (LN) metastatic (pN1) prostate cancer (PCa) patients showed worse survival in European patients. Contemporary rates of aRP are unknown in North America. OBJECTIVE: To examine the rate of aRP and its effect on cancer-specific mortality (CSM) in contemporary North American patients. DESIGN, SETTING, AND PARTICIPANTS: Within the Surveillance Epidemiology and End Results database (2004-2014), we identified 3719 pN1 PCa patients...
January 20, 2018: European Urology Focus
Z J Sun, X D Zhang, L Ren, X Y Yang, J F Cai, X Li, X Zheng, W Wang
Objective: To explore the relationship between creatinine reduction ratio (CRR) and delayed graft function among kidney transplant recipients from donor of cardiac death (DCD). To define the value of CRR to predict delayed graft function (DGF) in early post-transplant period. Method: 86 patients were included, who received renal transplantation from DCD during Jan 1(st) 2011 to Jun 30(th) 2016. We performed a retrospective study and collected creatinine data within 3 days post-operation and marked them with Cr1, Cr2 , Cr3, and then calculated creatinine reduction ratio day-2 (CRR 2) =(Cr1-Cr2)/Cr1×100% and creatinine reduction ratio day-3 (CRR 3)=[(Cr1-Cr2)/Cr1+ (Cr2-Cr3)/Cr2]/2×100%...
January 2, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Raisa S Pompe, Ariane Smith, Marco Bandini, Michele Marchioni, Tristan Martel, Felix Preisser, Sami-Ramzi Leyh-Bannurah, Jonas Schiffmann, Fred Saad, Hartwig Huland, Markus Graefen, Shahrokh F Shariat, Derya Tilki, Pierre I Karakiewicz
BACKGROUND: To examine clinical characteristics, treatment modalities and oncological outcomes of prostate cancer (PCa) according to young (≤50) vs. old age. METHODS: Of 407,599 men with primary adenocarcinoma of the prostate within the Surveillance, Epidemiology and End Results (SEER)-database (2004 to 2013), 18,387 were aged ≤50 years (4.5%). Time trends, cumulative incidence, and competing risks regression (CRR) analyses tested for differences between young and old patients...
April 2018: Prostate Cancer and Prostatic Diseases
Rahim Sharafkhani, Narges Khanjani, Bahram Bakhtiari, Yunes Jahani, Jafar Sadegh Tabrizi
There are few epidemiological studies about climate change and the effect of temperature variation on health using human thermal indices such as the Physiological Equivalent Temperature (PET) Index in Iran. This study was conducted in Tabriz, the northwest of Iran and Distributed Lag Non-linear Models (DLNM) combined with quasi-Poisson regression models were used to assess the impacts of PET on mortality by using the DLNM Package in R Software. The effect of air pollutants, time trend, day of the week and holidays were controlled as confounders...
January 2018: Journal of Thermal Biology
X Y Lu, S L Ren, J Z Lu, H Zong, J Song, B Zhuge
AIMS: This study aimed to strengthen the reducing equivalent generation in Klebsiella pneumoniae for improving 1,3-propanediol (PDO) production. METHODS AND RESULTS: Disruption of the arcA gene activated the transcription levels of the TCA cycle genes and thus increased the NADH/NAD+ ratio by 54·2%, leading to the improved PDO titre and yield per cell from 16·1 g l-1 and 4·0 g gDCW-1 to 18·8 g l-1 and 6·4 g gDCW-1 respectively. Further ldhA gene deletion eliminated lactate accumulation and promoted the PDO titre to 19·9 g l-1 ...
March 2018: Journal of Applied Microbiology
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