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https://www.readbyqxmd.com/read/28162880/surgical-management-of-periprosthetic-shoulder-infections
#1
Geoffrey P Stone, Rachel E Clark, Kathleen C O'Brien, Lisa Vaccaro, Peter Simon, Adam J Lorenzetti, Brent C Stephens, Mark A Frankle
BACKGROUND: The treatment of periprosthetic joint infection is a difficult challenge in shoulder arthroplasty. This study investigated 1-stage modular component exchange vs. 1-stage complete removal and reimplantation (CRR) vs. 2-stage revision arthroplasty for periprosthetic joint infection. METHODS: Between January 1, 2004, and December 31, 2012, 79 patients received a component exchange (n = 15), CRR (n = 45), or a 2-stage (n = 19) revision for infection. A binary logistic regression analysis was performed to determine factors presenting the greatest risk of reinfection...
February 2, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28132804/avrxa27-binding-influences-unwinding-of-the-double-stranded-dna-in-the-upt-box
#2
Jing Zhao, Bo Zhang, Junpeng Jiang, Nanv Liu, Qi Wei, Xuguang Xi, Jing Fu
Transcription-Activator Like (TAL) effectors, delivered by Xanthomonas pathogens bind specifically to UP-regulated by TAL effectors (UPT) box of the host gene promoter to arouse disease or trigger defense response. This type of protein-DNA interaction model has been applied in site-directed genome editing. However, the off-target effects of TAL have severely hindered the development of this promising technology. To better exploit the specific interaction and to deeper understand the TAL-induced host transcription rewiring, the binding between the central repeat region (CRR) of the TAL effector AvrXa27 and its UPT box variants was studied by kinetics analysis and TAL-blocked helicase unwinding assay...
January 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28093639/the-effectiveness-of-radiotherapy-for-leukemia-cutis
#3
Khaled Elsayad, Michael Oertel, Uwe Haverkamp, Hans Theodor Eich
BACKGROUND: Leukemia cutis (LC) is a rare clinical presentation of leukemia that is associated with poor prognosisabs. To date, the value of radiotherapy (RT) for the treatment of LC remains controversial. Therefore, the aim of this study was to analyse the effectiveness of various RT doses for LC. METHODS AND MATERIALS: Between January 2000 and January 2016, 13 patients underwent RT at our institution after exhibiting progressive disease following other treatment modalities...
January 16, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28092798/acute-kidney-injury-and-risk-of-deep-vein-thrombosis-and-pulmonary-embolism-in-taiwan-a-nationwide-retrospective-cohort-study
#4
Tsung-Hang Kuo, Hsin-Yang Li, Sheng-Hsiang Lin
INTRODUCTION: Chronic kidney disease (CKD) increases risk for deep vein thrombosis (DVT) and pulmonary embolism (PE). However, few studies have investigated the relationship between acute kidney injury (AKI) and risk of DVT and PE. Therefore, we conducted a nationwide longitudinal cohort study to determine whether patients with AKI are associated with increased risk of developing DVT and PE. METHODS: We included >30years-old inpatients (n=4734) receiving the diagnosis of AKI from 2000 to 2006 and their age-and sex-matched non-AKI inpatients using medical service in the same year (n=47...
January 6, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28078363/short-term-outcome-after-total-hip-arthroplasty-using-dual-mobility-cup-report-from-lithuanian-arthroplasty-register
#5
Sarunas Tarasevicius, Alfredas Smailys, Kazimieras Grigaitis, Otto Robertsson, Justinas Stucinskas
PURPOSE: The purpose of the study was to investigate how the use of dual-mobility cups (DMCs) affected the risk of revision due to dislocation as well as overall risk of revision compared with a conventional total hip arthroplasty (THA) system in the short term. METHODS: A total of 12,657 primary THAs were registered from the start of 2011 to the end of 2014. 620 THAs were with DMCs. For comparison, we included all registered THAs with Exeter cup and a cemented Exeter stem combined with 28-mm femoral head...
January 12, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28053304/-differences-in-the-recognition-of-occupational-diseases-by-sex-occupation-and-business-activity-in-spain-1990-2009
#6
Montserrat García Gómez, Rosario Castañeda López, Zaida Herrador Ortiz, Fernando Simón Soria
BACKGROUND: According to official statistics, men suffer more occupational diseases (OD) than women. Nevertheless, the unequal distribution and participation in the labor markets between men and women should be kept in mind. The purpose was to assess the gender impact in the recognition of OD in Spain, examining interaction and confounding factors. METHODS: An incidence study of the occupational diseases declared through the official OD reporting forms from 1999 to 2009, provided by the General Subdirectorate of Social and Labor Statistics of the Ministry of Employment and Social Security, was conducted...
January 9, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28047708/th-cd-207a-05-lung-surface-deformation-vector-fields-prediction-by-monitoring-respiratory-surrogate-signals
#7
J Nasehi Tehrani, A McEwan, J Wang
PURPOSE: In this study, we developed and evaluated a method for predicting lung surface deformation vector fields (SDVFs) based on surrogate signals such as chest and abdomen motion at selected locations and spirometry measurements. METHODS: A Patient-specific 3D triangular surface mesh of the lung region at end-expiration (EE) phase was obtained by threshold-based segmentation method. For each patient, a spirometer recorded the flow volume changes of the lungs; and 192 selected points at a regular spacing of 2cm X 2cm matrix points over a total area of 34cm X 24cm on the surface of chest and abdomen was used to detect chest wall motions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27965027/a-functional-centromere-lacking-cento-sequences-in-a-newly-formed-ring-chromosome-in-rice
#8
Rui Yang, Yafei Li, Yan Su, Yi Shen, Ding Tang, Qiong Luo, Zhukuan Cheng
An awned rice (Oryza sativa) plant carrying a tiny extra chromosome was discovered among the progeny of a telotrisomic line 2n+4L. Fluorescence in situ hybridization (FISH) using chromosome specific BAC clones revealed that this extra chromosome was a ring chromosome derived from part of the long arm of chromosome 4. So the aneuploidy plant was accordingly named as 2n+4L ring. We did not detect any CentO FISH signals on the ring chromosome, and found only the centromeric probe Centromeric Retrotransposon of Rice (CRR) was co-localized with the centromere-specific histone CENH3 as revealed by sequential FISH after immunodetection...
December 20, 2016: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/27914243/efficacy-and-safety-of-bevacizumab-containing-neoadjuvant-therapy-followed-by-interval-debulking-surgery-in-advanced-ovarian-cancer-results-from-the-anthalya-trial
#9
Roman Rouzier, Sébastien Gouy, Frédéric Selle, Eric Lambaudie, Anne Floquet, Virginie Fourchotte, Christophe Pomel, Pierre-Emmanuel Colombo, Elsa Kalbacher, Sandrine Martin-Francoise, Raffaele Fauvet, Philippe Follana, Anne Lesoin, Fabrice Lecuru, Youssef Ghazi, Julien Dupin, Elisabeth Chereau, Sarah Zohar, Paul Cottu, Florence Joly
AIM: To investigate whether adding bevacizumab to neoadjuvant carboplatin-paclitaxel (CP) helps achieve optimal debulking, measured by complete resection rate (CRR) at interval debulking surgery (IDS), in patients with initially unresectable International Federation of Gynecology and Obstetrics stage IIIC/IV ovarian, tubal or peritoneal adenocarcinoma. METHODS: Multicentre, open-label, non-comparative phase II study. Ninety-five patients randomised (2:1) to receive four cycles of neoadjuvant CP ±3 concomitant cycles of bevacizumab 15 mg/kg (BCP) followed by IDS...
January 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/27884597/prediction-of-competing-mortality-for-decision-making-between-surgery-or-observation-in-elderly-patients-with-t1-kidney-cancer
#10
Alessandro Larcher, Vincent Trudeau, Paolo Dell'Oglio, Zhe Tian, Katharina Boehm, Nicola Fossati, Umberto Capitanio, Alberto Briganti, Francesco Montorsi, Pierre Karakiewicz
OBJECTIVE: To predict the risk of cancer-specific mortality (CSM) or other-cause mortality (OCM) for T1 kidney cancer patients, aiming at identifying those who would benefit from surgery over observation. PATIENTS AND METHODS: Overall, 11,192 T1 kidney cancer patients treated with surgery or observation in the Surveillance, Epidemiology, and End Results-Medicare database were assessed. A competing risk regression (CRR) model was fitted to predict CSM and OCM after surgery or observation...
November 21, 2016: Urology
https://www.readbyqxmd.com/read/27875670/efficacy-of-carfilzomib-in-the-treatment-of-relapsed-and-or-refractory-multiple-myeloma-a-meta-analysis-of-data-from-clinical-trials
#11
Runzhe Chen, Baoan Chen, Xiaoping Zhang, Chong Gao
OBJECTIVE: Recently, carfilzomib has become a promising therapeutic approach for relapsed and (or) refractory multiple myeloma (RRMM), but no study has summarized the overall effect of carfilzomib in RRMM. To explore the role of carfilzomib, we performed a meta-analysis of all known prospective clinical trials to assess the efficacy of carfilzomib in patients with RRMM. METHODS AND MATERIALS: A systematic review of publications was performed on December 15, 2015...
October 2016: Discovery Medicine
https://www.readbyqxmd.com/read/27849650/programmed-cell-death-ligand-1-pd-l1-expression-in-anal-cancer
#12
Rangaswamy Govindarajan, Swetha Gujja, Eric R Siegel, Anu Batra, Anwaar Saeed, Keith Lai, Jennifer D James, Bradley J Fogel, Stephen Williamson
OBJECTIVE: To evaluate the expression of programmed cell death-ligand 1 (PD-L1) in anal cancer. PATIENTS AND METHODS: In a retrospective cohort analysis, subjects with squamous cell carcinoma of the anal canal were tested for PD-L1 expression, then followed for recurrence and survival. Crude recurrence rates (CRRs), crude mortality rates (CMRs), and crude event rates (CERs) were assessed for PD-L1-dependent differences using Poisson regression. All 3 types of crude rate were expressed as the number that occurred per hundred person-years (hPY) of follow-up...
November 15, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27833786/a-simple-and-sensitive-method-for-quantitative-measurement-of-methylmalonic-acid-by-turbulent-flow-chromatography-and-tandem-mass-spectrometry
#13
A G Tecleab, R C Schofield, L V Ramanathan, Dean C Carlow
A simple and sensitive method for the detection of methylmalonic acid in serum without derivatization has been developed. This method implements protein precipitation using methanol followed by additional sample clean up by turbulent flow liquid chromatography (TFLC). The sample was directly injected into the turbulent flow liquid chromatography tandem mass spectrometry system (TFLC-MS/MS) for online extraction followed by HPLC separation. The eluent was transferred to the mass spectrometer and ionized by heated electrospray negative ionization (HESI) and the analyte was quantified using a six-point calibration curve...
October 2016: Journal of Chromatography & Separation Techniques
https://www.readbyqxmd.com/read/27722992/molecular-characterization-of-a-novel-endornavirus-from-the-phytopathogenic-fungus-botrytis-cinerea
#14
Fangmin Hao, Ziliang Zhou, Mingde Wu, Guoqing Li
The complete sequence of a novel endornavirus (Botrytis cinerea endornavirus 1, BcEV1) from the phytopathogenic fungus Botrytis cinerea strain HBtom-372 was determined. The BcEV1 coding strand is 11,557 nucleotides long, possessing an open reading frame (ORF) that codes for a polyprotein of 3,787 amino acid residues and lacks a site-specific nick. The polyprotein contains viral methyltransferase (MTR) domain, a cysteine-rich region (CRR), two putative viral helicase (DEXDc-like and Hel-1) domains, and an RNA-dependent RNA polymerase_2 (RdRp_2) domain...
January 2017: Archives of Virology
https://www.readbyqxmd.com/read/27709912/cycloaddition-reactions-of-the-phosphinidene-bridged-complex-mo2cp-%C3%AE-%C3%AE%C2%BA-1-%C3%AE%C2%BA-1-%C3%AE-5-pc5h4-co-2-%C3%AE-6-hmes-with-diazoalkanes-and-other-heterocumulenes
#15
Isabel G Albuerne, M Angeles Alvarez, Inmaculada Amor, M Esther García, Daniel García-Vivó, Miguel A Ruiz
The title phosphinidene complex reacted at room temperature with CS2 and SCNPh to give the phosphanyl derivatives [Mo2Cp{μ-κ(2)P,S:κ(1)S',η(5)-P(CS2)C5H4}(CO)2(η(6)-HMes*)] and [Mo2Cp{μ-κ(2)P,S:κ(1)P,η(5)-P(C(NPh)S)C5H4}(CO)2(η(6)-HMes*)], respectively (Mes* = 2,4,6-C6H2(t)Bu3), which result from a [2 + 2] cycloaddition of a C═S bond in the organic reagent to the Mo═P bond of the phosphinidene complex, with further insertion of S into the remaining Mo-P bond, in the CS2 reaction. The title complex also reacted with diazoalkanes N2CRR' at room temperature to give the corresponding phosphaalkene derivatives [Mo2Cp{μ-η(2):κ(1)P,η(5)-P(CRR')C5H4}(CO)2(η(6)-HMes*)] (CRR' = CH2, CPh2, CH(SiMe3))...
October 6, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27681752/the-involvement-of-mitochondrial-membrane-potential-in-cross-resistance-between-radiation-and-docetaxel
#16
Yoshikazu Kuwahara, Mehryar Habibi Roudkenar, Masatoshi Suzuki, Yusuke Urushihara, Motoi Fukumoto, Yohei Saito, Manabu Fukumoto
PURPOSE: To understand the molecular mechanisms underlying cancer cell radioresistance, clinically relevant radioresistant (CRR) cells that continue to proliferate during exposure to 2 Gy/day X-rays for more than 30 days were established. A modified high-density survival assay for anticancer drug screening revealed that CRR cells were resistant to an antimicrotubule agent, docetaxel (DTX). The involvement of reactive oxygen species (ROS) from mitochondria (mtROS) in the cross-resistance to X-rays and DTX was studied...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27659252/asthma-is-associated-with-reduced-fibrinolytic-activity-abnormal-clot-architecture-and-decreased-clot-retraction-rate
#17
M M Tomasiak-Lozowska, T Misztal, T Rusak, J Branska-Januszewska, A Bodzenta-Lukaszyk, M Tomasiak
The aim of this study was to assess whether steroid-naïve asthma modulates hemostasis. We evaluated the clot retraction rate (CRR), fibrinolysis rate (FR), clot density (CD) (by confocal microscopy), plasma levels of plasminogen activator inhibitor (PAI-1), and factor XIII (FXIII), NO in exhaled breath (FENO ), spirometry (FEV1 ) and eosinophil count (EOS) in 36 patients with allergic, steroid-naïve asthma and in 34 healthy controls. We observed significantly (P < 0.001) reduced CRR, FR, and FEV1 and increased FENO , EOS, PAI-1, FXIII, and CD in patients with asthma compared with controls...
September 23, 2016: Allergy
https://www.readbyqxmd.com/read/27563551/when-and-how-to-replace-the-aortic-root-in-type-a-aortic-dissection
#18
Bradley G Leshnower, Edward P Chen
Management of aortic root pathology during repair of acute type A aortic dissection (TAAD) requires a comprehensive evaluation of the patient's anatomy, demographics, comorbidities and physiologic status at the time of emergent operative intervention. Surgical options include conservative repair of the root (CRR) (with or without replacement of the aortic valve), replacement of the native valve and aortic root using a composite valve-conduit and valve sparing root replacement (VSRR). The primary objective of this review is to provide data for surgeons to aid in their decision-making process regarding management of the aortic root during repair of TAAD...
July 2016: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27527805/conditional-risk-of-relapse-in-surveillance-for-clinical-stage-i-testicular-cancer
#19
Madhur Nayan, Michael A S Jewett, Ali Hosni, Lynn Anson-Cartwright, Philippe L Bedard, Malcolm Moore, Aaron R Hansen, Peter Chung, Padraig Warde, Joan Sweet, Martin O'Malley, Eshetu G Atenafu, Robert J Hamilton
BACKGROUND: Patients on surveillance for clinical stage I (CSI) testicular cancer are counseled regarding their baseline risk of relapse. The conditional risk of relapse (cRR), which provides prognostic information on patients who have survived for a period of time without relapse, have not been determined for CSI testicular cancer. OBJECTIVE: To determine cRR in CSI testicular cancer. DESIGN, SETTING, AND PARTICIPANTS: We reviewed 1239 patients with CSI testicular cancer managed with surveillance at a tertiary academic centre between 1980 and 2014...
January 2017: European Urology
https://www.readbyqxmd.com/read/27526778/bifunctional-interface-of-au-and-cu-for-improved-co2-electroreduction
#20
Seoin Back, Jun-Hyuk Kim, Yong-Tae Kim, Yousung Jung
Gold is known currently as the most active single-element electrocatalyst for CO2 electroreduction reaction to CO. In this work, we combine Au with a second metal element, Cu, to reduce the amount of precious metal content by increasing the surface-to-mass ratio and to achieve comparable activity to Au-based catalysts. In particular, we demonstrate that the introduction of a Au-Cu bifunctional "interface" is more beneficial than a simple and conventional homogeneous alloying of Au and Cu in stabilizing the key intermediate species, *COOH...
September 7, 2016: ACS Applied Materials & Interfaces
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