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https://www.readbyqxmd.com/read/28707036/treatment-strategies-for-rectal-cancer-with-synchronous-liver-metastases-surgical-and-oncological-outcomes-with-propensity-score-analysis
#1
H Salvador-Rosés, S López-Ben, P Planellas, E Canals, M Casellas-Robert, R Farrés, E Ramos, A Codina-Cazador, J Figueras
BACKGROUND: The optimal sequence of surgery for rectal cancer (RC) with synchronous liver metastases (SLM) is controversial. OBJECTIVES: The primary objective was to explore differences between the rectum first (RF) and the liver first strategy (LF) to achieve the complete resection (CR) of both tumors. METHODS: Patients diagnosed of RC with resectable or potentially resectable SLM were included. Data collected prospectively were analyzed with an intention-to-treat perspective, adjusting for between-sample differences (propensity score)...
July 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28687402/shift-within-age-groups-of-mumps-incidence-hospitalizations-and-severe-complications-in-a-highly-vaccinated-population-spain-1998-2014
#2
Noemí López-Perea, Josefa Masa-Calles, María de Viarce Torres de Mier, Aurora Fernández-García, Juan E Echevarría, Fernando De Ory, María Victoria Martínez de Aragón
The mumps vaccine (Jeryl-Lynn-strain) was introduced in Spain in 1981, and a vaccination policy which included a second dose was added in 1995. From 1992-1999, a Rubini-strain based vaccine was administered in many regions but later withdrawn due to lack of effectiveness. Despite high levels of vaccination coverage, epidemics have continued to appear. We characterized the three epidemic waves of mumps between 1998 and 2014, identifying major changes in susceptible populations using Poisson regression. For the period 1998-2003 (P1), the most affected group was from 1 to 4years old (y) [Incidence Rate (IR)=71...
July 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28656150/microarray-analysis-of-circular-rna-expression-profile-associated-with-5-fluorouracil-based-chemoradiation-resistance-in-colorectal-cancer-cells
#3
Wei Xiong, Yi-Qin Ai, Yun-Fen Li, Qing Ye, Zheng-Ting Chen, Ji-Yong Qin, Qiu-Yan Liu, Hong Wang, Yun-He Ju, Wen-Hui Li, Yun-Feng Li
Preoperative 5-fluorouracil- (5-FU-) based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, the effect of 5-FU-based chemoradiotherapy on CRC is limited due to the development of chemoradiation resistance (CRR), and the molecular mechanisms underlying this resistance are yet to be investigated. Recently, circular RNAs (circRNAs), which can function as microRNA sponges, were found to be involved in the development of several cancers. In this study, we focused on clarifying the modulation of the expression profiles of circRNAs in CRR...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28647401/human-papillomavirus-infection-increases-the-chemoradiation-response-of-esophageal-squamous-cell-carcinoma-based-on-p53-mutation
#4
Dakai Zhang, Wei Zhang, Wenzhi Liu, Yu Mao, Zhanzhao Fu, Jia Liu, Wei Huang, Zicheng Zhang, Dianzheng An, Baosheng Li
BACKGROUND AND PURPOSE: A retrospective study was carried out to analyze multiple prognostic predictors, including human papillomavirus (HPV) infection for chemoradiation treatment of esophageal squamous cell carcinoma (ESCC). MATERIALS AND METHODS: DNA extracted from a total of 192 patients treated with chemoradiation for locally advanced ESCC was examined to determine HPV status by polymerase chain reaction (PCR) and P53 gene mutation by genetic sequencing. The relationships between the chemoradiation response (CRR) and overall survival (OS) rate with HPV status and P53 gene mutation were analyzed...
June 21, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28640743/glucose-consumption-in-carbohydrate-mixtures-by-phosphotransferase-system-mutants-of-escherichia-coli
#5
Tian Xia, Neeraj Sriram, Sarah A Lee, Ronni Altman, Jeffrey L Urbauer, Elliot Altman, Mark A Eiteman
Escherichia coli lacking the glucose phosphotransferase system (PTS), mannose PTS and glucokinase are supposedly unable to grow on glucose as the sole carbon source (Curtis SJ, Epstein W. J Bacteriol 1975;122:1189-1199). We report that W ptsG manZ glk (ALS1406) grows slowly on glucose in media containing glucose with a second carbon source: ALS1406 metabolizes glucose after that other carbon source, including arabinose, fructose, glycerol, succinate or xylose, is exhausted. Galactose is an exception to this rule, as ALS1406 simultaneously consumes both galactose and glucose...
June 22, 2017: Microbiology
https://www.readbyqxmd.com/read/28618353/another-look-at-the-safety-effects-of-horizontal-curvature-on-rural-two-lane-highways
#6
Taha Saleem, Bhagwant Persaud
Crash Modification Factors (CMFs) are used to represent the effects on crashes of changes to highway design elements and are usually obtained from observational studies based on reported crashes. The design element of interest for this paper is horizontal curvature on rural 2-lane highways. The data for this study came from the Washington State database in the Highway Safety Information System (HSIS). Crash prediction models are developed for curve sections on rural 2-lane highway and the tangent sections up- and down-stream of the curve sections...
June 12, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28597542/the-efficacy-and-safety-of-gemcitabine-cisplatin-prednisone-thalidomide-versus-chop-in-patients-with-newly-diagnosed-peripheral-t-cell-lymphoma-with-analysis-of-biomarkers
#7
Ling Li, Wenjing Duan, Lei Zhang, Xin Li, Xiaorui Fu, Xinhua Wang, Jingjing Wu, Zhenchang Sun, Xudong Zhang, Yu Chang, Feifei Nan, Jiaqin Yan, Zhaoming Li, Ken H Young, Mingzhi Zhang
We compared the efficacy and safety of gemcitabine, cisplatin, prednisone and thalidomide (GDPT) with standard CHOP regimen (cyclophosphamide, doxorubicin, vincristine, prednisone) for patients with newly diagnosed peripheral T-cell lymphoma (PTCL) in a prospective randomized controlled and open-label clinical trial. Between July 2010 and June 2016, 103 patients were randomly allocated into two groups, of whom 52 were treated with GDPT therapy and 51 with CHOP therapy. The 2-year progression-free survival (PFS) and overall survival (OS) rates were better in the GDPT group than in the CHOP group (57% vs...
June 9, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28521865/exaggerated-glucagon-responses-to-hypoglycemia-in-women-with-polycystic-ovary-syndrome
#8
Susan Sam, Priyathama Vellanki, Sudha K Yalamanchi, Richard N Bergman, Andrea Dunaif
CONTEXT: Premenopausal women have blunted counter-regulatory hormone responses (CRR) to hypoglycemia compared to men. Postmenopausal women have CRR similar to men; the premenopausal pattern can be restored by estrogen. However, glucagon and pancreatic polypeptide (PP) responses remain lower in postmenopausal women than in men. Since hyperandrogenemia contributes to the metabolic phenotype of polycystic ovary syndrome (PCOS), we hypothesize that CRR to hypoglycemia especially of glucagon and PP is exaggerated in premenopausal women with PCOS compared to premenopausal control women...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28469356/submucosal-tunneling-endoscopic-resection-of-upper-gastrointestinal-tract-tumors-arising-from-muscularis-propria
#9
REVIEW
Deepanshu Jain, Aakash Desai, Ejaz Mahmood, Shashideep Singhal
The management of incidentally discovered small upper gastrointestinal (GI) tract submucosal tumors (SMT) remains debatable. In this review, we summarize the evolving experience with submucosal tunneling endoscopic resection (STER) of upper GI SMTs originating from the muscularis propria. From 16 original studies, we reviewed a total of 703 patients with 736 lesions. Of these, 436 were located in the esophagus, 146 in the esophagogastric junction (EGJ) and 154 in the stomach. The composite complete resection rate (CRR) for STER of upper GI tumors arising from the muscularis propria layer was 99...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28447341/chemotherapy-alone-versus-chemotherapy-plus-radiotherapy-for-adults-with-early-stage-hodgkin-lymphoma
#10
REVIEW
Oliver Blank, Bastian von Tresckow, Ina Monsef, Lena Specht, Andreas Engert, Nicole Skoetz
BACKGROUND: Combined modality treatment consisting of chemotherapy followed by localised radiotherapy is the standard treatment for patients with early stage Hodgkin lymphoma (HL). However, due to long- term adverse effects such as secondary malignancies the role of radiotherapy has been questioned recently and some clinical study groups advocate chemotherapy only for this indication. OBJECTIVES: To assess the effects of chemotherapy alone compared to chemotherapy plus radiotherapy in adults with early stage HL ...
April 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28418519/association-of-diet-with-skin-histological-features-in-uv-b-exposed-mice
#11
Tapan K Bhattacharyya, Yvonne Hsia, David M Weeks, Tatiana K Dixon, Jessica Lepe, J Regan Thomas
Importance: Long-term exposure to solar radiation produces deleterious photoaging of the skin. It is not known if diet can influence skin photoaging. Objectives: To study the influence of a calorie-restricted diet and an obesity diet in mice exposed to long-term UV-B irradiation to assess if there is an association between diet and histopathological response to UV-B irradiation. Design, Setting, and Participants: In this animal model study in an academic setting, the dorsal skin of SKH1 hairless mice receiving normal, calorie-restricted, and obesity diets was exposed to UV-B irradiation 3 times a week for 10 weeks and were compared with corresponding controls...
April 13, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28385454/local-therapy-improves-survival-in-metastatic-prostate-cancer
#12
Sami-Ramzi Leyh-Bannurah, Stéphanie Gazdovich, Lars Budäus, Emanuele Zaffuto, Alberto Briganti, Firas Abdollah, Francesco Montorsi, Jonas Schiffmann, Mani Menon, Shahrokh F Shariat, Margit Fisch, Felix Chun, Thomas Steuber, Hartwig Huland, Markus Graefen, Pierre I Karakiewicz
BACKGROUND: Treatment of the primary, termed local therapy (LT), may improve survival in metastatic prostate cancer (mPCa) versus no local therapy (NLT). OBJECTIVE: To assess cancer-specific mortality (CSM) after LT versus NLT in mPCa. DESIGN, SETTING, AND PARTICIPANTS: Within the Surveillance, Epidemiology and End Results database (2004-2013), 13 692 mPCa patients were treated with LT (radical prostatectomy [RP] or radiation therapy [RT]) or NLT...
April 3, 2017: European Urology
https://www.readbyqxmd.com/read/28321894/light-respiration-by-subtropical-seaweeds
#13
Matheus C Carvalho, Bradley D Eyre
Here, we report the first-ever measurements of light CO2 respiration rate (CRR) by seaweeds. We measured the influence of temperature (15-25°C) and light (irradiance from 60 to 670 μmol · m(-2)  · s(-1) ) on the light CCR of two subtropical seaweed species, and measured the CRR of seven different seaweed species under the same light (150 μmol · m(-2)  · s(-1) ) and temperature (25°C). There was little effect of irradiance on light CRR, but there was an effect of temperature. Across the seven species light CRR was similar to OCR (oxygen consumption rate in the dark), with the exception of a single species...
June 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28290247/modulation-of-retinal-arteriolar-central-reflection-by-apoe-genotype
#14
Shaun Frost, Alauddin Bhuiyan, David Offerman, James D Doecke, S Lance Macaulay, Hamid R Sohrabi, David Ames, Colin Masters, Ralph N Martins, Yogesan Kanagasingam, Aibl Research Group
This study investigated the retinal arteriolar central reflex (CR, the central reflection observed in photographs of retinal vessels), which may provide information about micro-vascular health in the retina and also the brain, due to the homology between these vascular networks. The study also describes a novel computer based semi-automated technique that accurately quantifies retinal arteriolar CR and vessel width, and calculates the CR to vessel width ratio (CRR) from digital retinal photographs. Digital retinal photographs were collected from participants in the Australian Imaging, Biomarkers and Lifestyle study of ageing (AIBL), including 25 participants diagnosed with Alzheimer's disease (AD) (age 72...
March 9, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28269291/on-the-invariance-of-eeg-based-signatures-of-individuality-with-application-in-biometric-identification
#15
Yunqi Wang, Laleh Najafizadeh
One of the main challenges in EEG-based biometric systems is to extract reliable signatures of individuality from recorded EEG data that are also invariant against time. In this paper, we investigate the invariability of features that are extracted based on the spatial distribution of the spectral power of EEG data corresponding to 2-second eyes-closed resting-state (ECRS) recording, in different scenarios. Eyes-closed resting-state EEG signals in 4 healthy adults are recorded in two different sessions with an interval of at least one week between sessions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28251126/survival-analysis-in-the-presence-of-competing-risks
#16
EDITORIAL
Zhongheng Zhang
Survival analysis in the presence of competing risks imposes additional challenges for clinical investigators in that hazard function (the rate) has no one-to-one link to the cumulative incidence function (CIF, the risk). CIF is of particular interest and can be estimated non-parametrically with the use cuminc() function. This function also allows for group comparison and visualization of estimated CIF. The effect of covariates on cause-specific hazard can be explored using conventional Cox proportional hazard model by treating competing events as censoring...
February 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28242601/a-genetic-study-of-the-regeneration-capacity-of-embryonic-callus-from-the-maize-immature-embryo-culture
#17
Zhang Xiaoling, Long Yun, Ge Fei, Guan Zhongrong, Zhang Xiaoxiang, Wang Yanli, Shen Yaou, Pan Guangtang
We carried out a study of regeneration capacities of embryonic callus from maize immature embryo culture with 144 different inbred lines of natural groups from different countries, and found that the regeneration capacity was affected by three factors: environment, genotype and the interaction between the environment and genotype. We found that green embryonic callus rate (GCR), embryonic callus differentiating rate (CDR) and the plantlet number of embryonic callus regeneration (CPN) have significant positive correlations with each other, and they all have significant negative correlations with embryonic callus browning rate (CBR)...
February 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28227527/on-the-invariance-of-eeg-based-signatures-of-individuality-with-application-in-biometric-identification
#18
Yunqi Wang, Laleh Najafizadeh, Yunqi Wang, Laleh Najafizadeh, Yunqi Wang, Laleh Najafizadeh
One of the main challenges in EEG-based biometric systems is to extract reliable signatures of individuality from recorded EEG data that are also invariant against time. In this paper, we investigate the invariability of features that are extracted based on the spatial distribution of the spectral power of EEG data corresponding to 2-second eyes-closed resting-state (ECRS) recording, in different scenarios. Eyes-closed resting-state EEG signals in 4 healthy adults are recorded in two different sessions with an interval of at least one week between sessions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28162880/surgical-management-of-periprosthetic-shoulder-infections
#19
Geoffrey P Stone, Rachel E Clark, Kathleen C O'Brien, Lisa Vaccaro, Peter Simon, Adam J Lorenzetti, Brent C Stephens, Mark A Frankle
BACKGROUND: The treatment of periprosthetic joint infection is a difficult challenge in shoulder arthroplasty. This study investigated 1-stage modular component exchange vs. 1-stage complete removal and reimplantation (CRR) vs. 2-stage revision arthroplasty for periprosthetic joint infection. METHODS: Between January 1, 2004, and December 31, 2012, 79 patients received a component exchange (n = 15), CRR (n = 45), or a 2-stage (n = 19) revision for infection. A binary logistic regression analysis was performed to determine factors presenting the greatest risk of reinfection...
February 2, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28132804/avrxa27-binding-influences-unwinding-of-the-double-stranded-dna-in-the-upt-box
#20
Jing Zhao, Bo Zhang, Junpeng Jiang, Nanv Liu, Qi Wei, Xuguang Xi, Jing Fu
Transcription-Activator Like (TAL) effectors, delivered by Xanthomonas pathogens bind specifically to UP-regulated by TAL effectors (UPT) box of the host gene promoter to arouse disease or trigger defense response. This type of protein-DNA interaction model has been applied in site-directed genome editing. However, the off-target effects of TAL have severely hindered the development of this promising technology. To better exploit the specific interaction and to deeper understand the TAL-induced host transcription rewiring, the binding between the central repeat region (CRR) of the TAL effector AvrXa27 and its UPT box variants was studied by kinetics analysis and TAL-blocked helicase unwinding assay...
March 4, 2017: Biochemical and Biophysical Research Communications
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