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https://www.readbyqxmd.com/read/29339806/tumor-characteristics-treatments-and-oncological-outcomes-of-prostate-cancer-in-men-aged-%C3%A2-50-years-a-population-based-study
#1
Raisa S Pompe, Ariane Smith, Marco Bandini, Michele Marchioni, Tristan Martel, Felix Preisser, Sami-Ramzi Leyh-Bannurah, Jonas Schiffmann, Fred Saad, Hartwig Huland, Markus Graefen, Shahrokh F Shariat, Derya Tilki, Pierre I Karakiewicz
BACKGROUND: To examine clinical characteristics, treatment modalities and oncological outcomes of prostate cancer (PCa) according to young (≤50) vs. old age. METHODS: Of 407,599 men with primary adenocarcinoma of the prostate within the Surveillance, Epidemiology and End Results (SEER)-database (2004 to 2013), 18,387 were aged ≤50 years (4.5%). Time trends, cumulative incidence, and competing risks regression (CRR) analyses tested for differences between young and old patients...
January 16, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29301690/physiological-equivalent-temperature-index-and-mortality-in-tabriz-the-northwest-of-iran
#2
Rahim Sharafkhani, Narges Khanjani, Bahram Bakhtiari, Yunes Jahani, Jafar Sadegh Tabrizi
There are few epidemiological studies about climate change and the effect of temperature variation on health using human thermal indices such as the Physiological Equivalent Temperature (PET) Index in Iran. This study was conducted in Tabriz, the northwest of Iran and Distributed Lag Non-linear Models (DLNM) combined with quasi-Poisson regression models were used to assess the impacts of PET on mortality by using the DLNM Package in R Software. The effect of air pollutants, time trend, day of the week and holidays were controlled as confounders...
January 2018: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29297957/enhanced-1-3-propanediol-production-in-klebsiella-pneumoniae-by-a-combined-strategy-of-strengthening-the-tca-cycle-and-weakening-the-glucose-effect
#3
Xinyao Lu, Shunli Ren, Jingzheng Lu, Hong Zong, Jian Song, Bin Zhuge
AIMS: This study aimed to strengthen the reducing equivalent regeneration in Klebsiella pneumoniae for improving 1,3-propanediol (PDO) production. METHODS AND RESULTS: Disruption of the arcA gene activated the transcription levels of the TCA cycle genes and thus increased the NADH/NAD+ ratio by 54.2%, leading to the improved PDO titer and yield per cell from 16.1 g l-1 and 4.0 g gDCW-1 to 18.8 g l-1 and 6.4 g gDCW-1 , respectively. Further ldhA gene deletion eliminated lactate accumulation and promoted the PDO titer to 19...
January 3, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29204707/ocular-surface-and-tear-film-status-among-contact-lens-wearers-and-non-wearers-who-use-vdt-at-work-comparing-three-different-lens-types
#4
Ana Tauste, Elena Ronda, Valborg Baste, Magne Bråtveit, Bente E Moen, María-Del-Mar Seguí Crespo
PURPOSE: To analyze differences in the ocular surface appearance and tear film status of contact lens wearers and non-wearers in a group of visual display terminals (VDT) workers and additionally to assess differences between lens materials. METHODS: Cross-sectional study of 236 office workers, of whom 92 were contact lens wearers. Workers provided information on their contact lenses (conventional hydrogel, silicone hydrogel or rigid gas permeable lenses) and exposure to VDT at work...
December 4, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29184103/inconsistency-in-the-crown-to-root-ratios-of-single-rooted-premolars-measured-by-2d-and-3d-examinations
#5
Hsiang-Hsi Hong, Heng-Liang Liu, Adrienne Hong, Pu Chao
Micro-computed tomography (micro-CT) was applied to elucidate the relationship between the three-dimensional (3D) root surface area (RSA) and two-dimensional (2D) crown-to-root ratio (CRR) of extracted teeth to classify the periodontitis and assign a periodontal/prosthetic prognosis. A total of 31 maxillary and 35 mandibular single-rooted human premolars were examined. The amount of periodontal support on the basis of 3D RSA and 2D root length (RL) at CRRs of 1:1, 5:4, 3:2, and 2:1 were analyzed. Both maxillary and mandibular premolars demonstrated a nonsignificant RSA percentage at the evaluated CRRs...
November 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29170159/reduced-expression-of-cardiac-ryanodine-receptor-protects-against-stress-induced-ventricular-tachyarrhythmia-but-increases-the-susceptibility-to-cardiac-alternans
#6
Xiaowei Zhong, Alexander Vallmitjana, Bo Sun, Zhichao Xiao, Wenting Guo, Jinhong Wei, Mingke Ni, Yongxiang Chen, Edward R O'Brien, Anne M Gillis, Masahiko Hoshijima, Hiroshi Takeshima, Leif Hove-Madsen, Raul Benitez, Darrell Belke, S R Wayne Chen
Reduced protein expression of the cardiac ryanodine receptor (RyR2) is thought to affect the susceptibility to stress-induced ventricular tachyarrhythmia (VT) and cardiac alternans, but direct evidence for the role of RyR2 protein expression in VT and cardiac alternans is lacking. Here we used a mouse model ( crrm1) that expresses a reduced level of the RyR2 protein to determine the impact of reduced RyR2 protein expression on the susceptibility to VT, cardiac alternans, cardiac hypertrophy, and sudden death...
November 23, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29168251/bendamustine-plus-rituximab-for-indolent-b-cell-lymphoma-of-renal-significance
#7
David Ribes, Hélène E L Hachem, Lucie Oberic, François Vergez, Audrey Delas, Julie Belliere, Caroline Protin, Nassim Kamar, Inès Ferrandiz, Suzanne Tavitian, Camille Laurent, Antoine Huart, Dominique Chauveau, Loïc Ysebaert, Stanislas Faguer
Treatment of indolent B-cell non-Hodgkin lymphomas (iNHL) of renal significance is challenging given the need for deep and prolonged hematological response to restore and control renal function overtime, yet to be balanced with the risk of adverse drug-related events. This prospective single-center study included 20 patients with iNHL of renal significance (tubulointerstitial presentation [n = 8], glomerulopathy with or without monoclonal Ig deposits [n = 12]) who received a steroid-sparing regimen of rituximab plus bendamustine (BR), with either no or <1 month of steroid intake (as a first line therapy in 80%)...
November 23, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29158285/neoadjuvant-palbociclib-on-er-breast-cancer-n007-clinical-response-and-endopredict-value
#8
Louis Wc Chow, Satoshi Morita, Christopher Yc Chow, Wai Kuen Ng, Masakazu Toi
To test the efficacy of neoadjuvant palbociclib therapy and to evaluate its impact on cell cycle arrest and changes in EndoPredict (EP) scores before and after treatment. Postmenopausal women with histologically proven ER+ve, HER2-ve invasive breast cancer, 2cm or greater, were enrolled in an open-label, single arm study. Twenty eligible patients were given letrozole 2.5mg per day together with palbociclib 125mg per day for 3 out of 4 weeks in repeated cycles for 16 weeks (4 cycles) before surgery. The primary end-points were clinical response rates (cRR) and preoperative endocrine prognostic index (PEPI)...
November 20, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29155538/aetiological-histopathological-clinical-diagnostic-and-therapeutical-features-of-idiopathic-cervical-resorption
#9
Virginia Robles Gijón, Cristina Lucena Martín, Rosa Mª Pulgar Encinas, José Manuel Navajas
Root resorption is the loss of hard dental tissue as a result of odontoclastic action involving vital and pulpless teeth. Cervical root resorption (CRR) is a type of external resorption which usually occurs immediately below the epithelial attachment of the tooth in the cervical region. The idiopathic cervical resorption (ICR) refers to a clinical situation in which all other causes, whether local or systemic, have been ruled out as the origin of the disease. The early stage is asymptomatic and might be diagnosed by a routine radiograph or a clinical examination...
December 2016: Dental Update
https://www.readbyqxmd.com/read/29152503/nomogram-for-survival-analysis-in-the-presence-of-competing-risks
#10
EDITORIAL
Zhongheng Zhang, Ronald B Geskus, Michael W Kattan, Haoyang Zhang, Tongyu Liu
Clinical research usually involves time-to-event survival analysis, in which the presence of a competing event is prevalent. It is acceptable to use the conventional Cox proportional hazard regression to model cause-specific hazard. However, this cause-specific hazard cannot directly translate to the cumulative incidence function, and the latter is usually clinically relevant. The subdistribution hazard regression directly quantifies the impact of covariates on the cumulative incidence. When estimating the subdistribution hazard, subjects experiencing competing event continue to contribute to the risk set, and censoring weights are assigned to them after the competing event time...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29151346/molecular-scaffolding-strategy-with-synergistic-active-centers-to-facilitate-electrocatalytic-co2-reduction-to-hydrocarbon-alcohol
#11
Yan Jiao, Yao Zheng, Ping Chen, Mietek Jaroniec, Shi-Zhang Qiao
A major impediment of the electrocatalytic CO2 reduction reaction (CRR) is the lack of electrocatalysts with both high efficiency and good selectivity toward liquid fuels or other valuable chemicals. Effective strategies for the design of electrocatalysts are yet to be discovered to substitute the conventional trial-and-error approach. This work shows that a combination of the density functional theory (DFT) computation and experimental validation on molecular scaffolding to coordinate the metal active centers presents a new molecular-level strategy for the development of electrocatalysts with high CRR selectivity toward hydrocarbon/alcohol...
November 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29112335/heterojunction-assisted-co3-s4-co3-o4-core-shell-octahedrons-for-supercapacitors-and-both-oxygen-and-carbon-dioxide-reduction-reactions
#12
Yibo Yan, Kaixin Li, Xiaoping Chen, Yanhui Yang, Jong-Min Lee
Expedition of electron transfer efficiency and optimization of surface reactant adsorption products desorption processes are two main challenges for developing non-noble catalysts in the oxygen reduction reaction (ORR) and CO2 reduction reaction (CRR). A heterojunction prototype on Co3 S4 @Co3 O4 core-shell octahedron structure is established via hydrothermal lattice anion exchange protocol to implement the electroreduction of oxygen and carbon dioxide with high performance. The synergistic bifunctional catalyst consists of p-type Co3 O4 core and n-type Co3 S4 shell, which afford high surface electron density along with high capacitance without sacrificing mechanical robustness...
November 7, 2017: Small
https://www.readbyqxmd.com/read/29111173/epidermal-growth-factor-receptor-mutation-predicts-favorable-outcomes-in-non-small-cell-lung-cancer-patients-with-brain-metastases-treated-with-stereotactic-radiosurgery
#13
Wen-Chi Yang, Furen Xiao, Jin-Yuan Shih, Chao-Chi Ho, Ya-Fang Chen, Ham-Min Tseng, Kuan-Yu Chen, Wei-Yu Liao, Chong-Jen Yu, James Chih-Hsin Yang, Sung-Hsin Kuo, Jason Chia-Hsien Cheng, Pan-Chyr Yang, Feng-Ming Hsu
PURPOSE: The impact of epidermal growth factor receptor (EGFR) mutations on radiotherapy for brain metastases (BM) is undetermined. We evaluated the effects of EGFR mutation status on responses and outcomes in non-small cell lung cancer (NSCLC) patients with BM, treated with upfront or salvage stereotactic radiosurgery (SRS). METHODS AND MATERIALS: From 2008 to 2015, 147 eligible NSCLC patients with 300 lesions were retrospectively analyzed. Patterns of tyrosine kinase inhibitor (TKI) therapy were recorded...
October 27, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29079703/thioredoxin-1-overexpression-in-the-ventromedial-nucleus-of-the-hypothalamus-vmh-preserves-the-counterregulatory-response-to-hypoglycemia-during-type-1-diabetes-mellitus-in-male-rats
#14
Chunxue Zhou, Vanessa H Routh
We previously showed that the glutathione precursor, N-acetylcysteine (NAC), prevented hypoglycemia-associated autonomic failure (HAAF) and impaired activation of ventromedial hypothalamus (VMH) glucose-inhibited (GI) neurons by low glucose after recurrent hypoglycemia (RH) in non-diabetic rats. However, NAC does not normalize glucose sensing by VMH GI neurons when RH occurs during diabetes. We hypothesized that recruiting the thioredoxin (Trx) antioxidant defense system would prevent HAAF and normalize glucose sensing after RH in diabetes...
October 27, 2017: Diabetes
https://www.readbyqxmd.com/read/29067564/clinically-relevant-radioresistant-cell-line-a-simple-model-to-understand-cancer-radioresistance
#15
REVIEW
Yoshikazu Kuwahara, Mehryar Habibi Roudkenar, Yusuke Urushihara, Yohei Saito, Kazuo Tomita, Amaneh Mohammadi Roushandeh, Tomoaki Sato, Akihiro Kurimasa, Manabu Fukumoto
Radiotherapy (RT) is one of the major modalities for the treatment of human cancers and has been established as an excellent local treatment for malignant tumors. Conventional fractionated RT consists of 2-Gy X-rays, fractionated once a day, 5 days a week for 5-7 weeks in total 60 Gy. The efficacy of RT depends on the existence of radioresistant cells, which remains one of the most critical obstacles in RT and radio-chemotherapy. To improve the efficacy of RT, understanding the characteristics of radioresistant cells is one of the important subjects in radiation biology...
December 2017: Medical Molecular Morphology
https://www.readbyqxmd.com/read/29063268/radical-prostatectomy-or-radiotherapy-reduce-prostate-cancer-mortality-in-elderly-patients-a-population-based-propensity-score-adjusted-analysis
#16
Marco Bandini, Raisa S Pompe, Michele Marchioni, Zhe Tian, Giorgio Gandaglia, Nicola Fossati, Derya Tilki, Markus Graefen, Francesco Montorsi, Shahrokh F Shariat, Alberto Briganti, Fred Saad, Pierre I Karakiewicz
PURPOSE: Contemporary data regarding the effect of local treatment (LT) vs. non-local treatment (NLT) on cancer-specific mortality (CSM) in elderly men with localized prostate cancer (PCa) are lacking. Hence, we evaluated CSM rates in a large population-based cohort of men with cT1-T2 PCa according to treatment type. METHODS: Within the SEER database (2004-2014), we identified 44,381 men ≥ 75 years with cT1-T2 PCa. Radical prostatectomy and radiotherapy patients were matched and the resulting cohort (LT) was subsequently matched with NLT patients...
October 23, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29037395/diurnal-temperature-range-and-mortality-in-urmia-the-northwest-of-iran
#17
Rahim Sharafkhani, Narges Khanjani, Bahram Bakhtiari, Yunes Jahani, Rasool Entezar Mahdi
Diurnal Temperature Range (DTR) is a meteorological index which represents temperature variation within a day. This study assesses the impact of high and low values of DTR on mortality. Distributed Lag Non-linear Models combined with a quasi-Poisson regression model was used to assess the impact of DTR on cause, age and gender specific mortality, controlled for potential confounders such as long-term trend of daily mortality, day of week effect, holidays, mean temperature, humidity, wind speed and air pollutants...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28952220/cetuximab-versus-nimotuzumab-for-the-treatment-of-advanced-nasopharyngeal-carcinoma-a-network-meta-analysis
#18
Cheng Yuan, Xin-Hua Xu, Lu Xu, Yang Liu, Min Sun, Li-Hua Ni, Xiao-Long Wang, Zhuo Chen, Kun Zhang, Hua-Li Wan, Guang Zeng
PURPOSE: We conducted a network meta-analysis to evaluate the efficacy and toxicity of cetuximab and nimotuzumab in the treatment of advanced nasopharyngeal carcinoma (NPC). METHODS: A systematic literature search was performed though Pubmed, Embase, Cochran Library, China National Knowledge Infrastructure (CNKI), Chinese Biomedical (CBM) and Wanfang databases. Totally, 19 randomized controlled trials (RCTs) (n=1201) met the study selection criteria and were incorporated in this network meta-analysis...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28932952/survival-of-metastatic-renal-cell-carcinoma-patients-continues-to-improve-over-time-even-in-targeted-therapy-era
#19
Michele Marchioni, Marco Bandini, Raisa S Pompe, Zhe Tian, Tristan Martel, Anil Kapoor, Luca Cindolo, Francesco Berardinelli, Alberto Briganti, Shahrokh F Shariat, Luigi Schips, Pierre I Karakiewicz
OBJECTIVE: To examine the effect of diagnosis year, defined as contemporary (2010-2014), intermediate (2006-2009) and historical (2001-2005) on cancer-specific mortality (CSM) in patients with metastatic renal cell carcinoma (mRCC). METHODS: Within Surveillance, Epidemiology, and End Results registry (2001-2014), we identified patients with mRCC. Cumulative incidence and competing risks regression (CRR) models examined CSM, after accounting for other-cause mortality...
December 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28906353/immunomodulatory-treatments-for-persistent-and-chronic-immune-thrombocytopenic-purpura-a-prisma-compliant-systematic-review-and-meta-analysis-of-28-studies
#20
REVIEW
Emmanuelle Weber, Quitterie Reynaud, Romain Fort, Stéphane Durupt, Pascal Cathébras, Isabelle Durieu, Jean-Christophe Lega
BACKGROUND: Corticosteroid sparing is required in 15% to 40% of adults with persistent or chronic primary immune thrombocytopenic purpura (ITP). Herein, the efficacy of immunomodulatory drugs (dapsone, interferon alpha, danazol, and hydroxychloroquine as second-third-line therapies in ITP is investigated. METHODS: MEDLINE was searched for studies that included patients with persistent or chronic primary ITP and published before the end of December 2014. Two investigators independently extracted data regarding study design, patient characteristics, dosage schedule, time to response, and occurrence of adverse events...
September 2017: Medicine (Baltimore)
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