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Fangmin Hao, Ziliang Zhou, Mingde Wu, Guoqing Li
The complete sequence of a novel endornavirus (Botrytis cinerea endornavirus 1, BcEV1) from the phytopathogenic fungus Botrytis cinerea strain HBtom-372 was determined. The BcEV1 coding strand is 11,557 nucleotides long, possessing an open reading frame (ORF) that codes for a polyprotein of 3,787 amino acid residues and lacks a site-specific nick. The polyprotein contains viral methyltransferase (MTR) domain, a cysteine-rich region (CRR), two putative viral helicase (DEXDc-like and Hel-1) domains, and an RNA-dependent RNA polymerase_2 (RdRp_2) domain...
October 8, 2016: Archives of Virology
Isabel G Albuerne, M Angeles Alvarez, Inmaculada Amor, M Esther García, Daniel García-Vivó, Miguel A Ruiz
The title phosphinidene complex reacted at room temperature with CS2 and SCNPh to give the phosphanyl derivatives [Mo2Cp{μ-κ(2)P,S:κ(1)S',η(5)-P(CS2)C5H4}(CO)2(η(6)-HMes*)] and [Mo2Cp{μ-κ(2)P,S:κ(1)P,η(5)-P(C(NPh)S)C5H4}(CO)2(η(6)-HMes*)], respectively (Mes* = 2,4,6-C6H2(t)Bu3), which result from a [2 + 2] cycloaddition of a C═S bond in the organic reagent to the Mo═P bond of the phosphinidene complex, with further insertion of S into the remaining Mo-P bond, in the CS2 reaction. The title complex also reacted with diazoalkanes N2CRR' at room temperature to give the corresponding phosphaalkene derivatives [Mo2Cp{μ-η(2):κ(1)P,η(5)-P(CRR')C5H4}(CO)2(η(6)-HMes*)] (CRR' = CH2, CPh2, CH(SiMe3))...
October 6, 2016: Inorganic Chemistry
Yoshikazu Kuwahara, Mehryar Habibi Roudkenar, Masatoshi Suzuki, Yusuke Urushihara, Motoi Fukumoto, Yohei Saito, Manabu Fukumoto
PURPOSE: To understand the molecular mechanisms underlying cancer cell radioresistance, clinically relevant radioresistant (CRR) cells that continue to proliferate during exposure to 2 Gy/day X-rays for more than 30 days were established. A modified high-density survival assay for anticancer drug screening revealed that CRR cells were resistant to an antimicrotubule agent, docetaxel (DTX). The involvement of reactive oxygen species (ROS) from mitochondria (mtROS) in the cross-resistance to X-rays and DTX was studied...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
M M Tomasiak-Lozowska, T Misztal, T Rusak, J Branska-Januszewska, A Bodzenta-Lukaszyk, M Tomasiak
The aim of this study was to assess whether steroid-naïve asthma modulates hemostasis. We evaluated the clot retraction rate (CRR), fibrinolysis rate (FR), clot density (CD) (by confocal microscopy), plasma levels of plasminogen activator inhibitor (PAI-1), and factor XIII (FXIII), NO in exhaled breath (FENO ), spirometry (FEV1 ) and eosinophil count (EOS) in 36 patients with allergic, steroid-naïve asthma and in 34 healthy controls. We observed significantly (P < 0.001) reduced CRR, FR, and FEV1 and increased FENO , EOS, PAI-1, FXIII, and CD in patients with asthma compared with controls...
September 23, 2016: Allergy
Bradley G Leshnower, Edward P Chen
Management of aortic root pathology during repair of acute type A aortic dissection (TAAD) requires a comprehensive evaluation of the patient's anatomy, demographics, comorbidities and physiologic status at the time of emergent operative intervention. Surgical options include conservative repair of the root (CRR) (with or without replacement of the aortic valve), replacement of the native valve and aortic root using a composite valve-conduit and valve sparing root replacement (VSRR). The primary objective of this review is to provide data for surgeons to aid in their decision-making process regarding management of the aortic root during repair of TAAD...
July 2016: Annals of Cardiothoracic Surgery
Madhur Nayan, Michael A S Jewett, Ali Hosni, Lynn Anson-Cartwright, Philippe L Bedard, Malcolm Moore, Aaron R Hansen, Peter Chung, Padraig Warde, Joan Sweet, Martin O'Malley, Eshetu G Atenafu, Robert J Hamilton
BACKGROUND: Patients on surveillance for clinical stage I (CSI) testicular cancer are counseled regarding their baseline risk of relapse. The conditional risk of relapse (cRR), which provides prognostic information on patients who have survived for a period of time without relapse, have not been determined for CSI testicular cancer. OBJECTIVE: To determine cRR in CSI testicular cancer. DESIGN, SETTING, AND PARTICIPANTS: We reviewed 1239 patients with CSI testicular cancer managed with surveillance at a tertiary academic centre between 1980 and 2014...
August 12, 2016: European Urology
Seoin Back, Jun-Hyuk Kim, Yong-Tae Kim, Yousung Jung
Gold is known currently as the most active single-element electrocatalyst for CO2 electroreduction reaction to CO. In this work, we combine Au with a second metal element, Cu, to reduce the amount of precious metal content by increasing the surface-to-mass ratio and to achieve comparable activity to Au-based catalysts. In particular, we demonstrate that the introduction of a Au-Cu bifunctional "interface" is more beneficial than a simple and conventional homogeneous alloying of Au and Cu in stabilizing the key intermediate species, *COOH...
September 7, 2016: ACS Applied Materials & Interfaces
Lei Zhang, Sucai Li, Sisi Jia, Feifei Nan, Zhaoming Li, Jingyu Cao, Shanshan Fan, Chao Zhang, Liping Su, Jinghua Wang, Hongwei Xue, Mingzhi Zhang
Extranodal natural killer/T cell lymphoma (ENKL) is a high invasive disease with poor prognosis. Since there is no consensus on standard chemotherapy, we developed an original chemotherapeutic DDGP (cisplatin, dexamethasone, gemcitabine, and pegaspargase) regimen. We retrospectively analyzed 80 patients who received DDGP chemotherapy. The primary end point was progression-free survival (PFS) and secondary end points were overall survival (OS), complete response rate (CRR), and overall response rate (ORR). The one-year PFS and OS rates were 86...
August 9, 2016: Oncotarget
Hassan Ahmadvand, Shahrokh Bagheri, Ahmad Tamjidi-Poor, Mostafa Cheraghi, Mozhgan Azadpour, Behrouz Ezatpour, Sanaz Moghadam, Gholamreza Shahsavari, Masumeh Jalalvand
BACKGROUND: Oleuropein is a natural antioxidant and scavenging free radicals. In the present study, we examined effect of oleuropein on the paraoxonase 1 (PON1) activity, lipid peroxidation, lipid profile, atherogenic indexes, and relationship of PON1 activity by high-density lipoprotein-cholesterol (HDL-C) and atherogenic indices in gentamicin (GM)-induced nephrotoxicity in rats. METHODS: This is a lab trial study in Khorramabad, Lorestan province of Iran (2013)...
March 2016: ARYA Atherosclerosis
Gregory P Boivin, Michael A Bottomley, Emily S Dudley, Patricia A Schiml, Christopher N Wyatt, Nadja Grobe
Rodent euthanasia with CO2 by using gradual displacement of 10% to 30% of the chamber volume per minute is considered acceptable by the AVMA Panel on Euthanasia. However, whether a 50% to 100% chamber replacement rate (CRR) of CO2 is more painful or distressful than 10% to 30% CRR is unclear. Therefore, we examined physiological and behavioral parameters, corticosterone and ACTH levels, and lung histology of mice euthanized at CRR of 15%, 30%, 50%, or 100%. Adult male C57BL/6N mice were euthanized at different CO2 CRR as physiological parameters were recorded telemetrically...
2016: Journal of the American Association for Laboratory Animal Science: JAALAS
Rui Bi, Yiou Pan, Qingli Shang, Tianfei Peng, Shuang Yang, Shang Wang, Xuecheng Xin, Yan Liu, Jinghui Xi
Lambda-cyhalothrin is now widely used in China to control the soybean aphid Aphis glycines. To dissect the resistance mechanism, a laboratory-selected resistant soybean aphid strain (CRR) was established with a 43.42-fold resistance ratio to λ-cyhalothrin than the susceptible strain (CSS) in adult aphids. In this study, a comparative proteomic analysis between the CRR and CSS strains revealed important differences between the susceptible and resistant strains of soybean aphids for λ-cyhalothrin. Approximately 493 protein spots were detected in two-dimensional polyacrylamide gel electrophoresis (2-DE)...
September 2016: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
Ryusei Matsuyama, Ryutaro Mori, Yohei Ota, Yuki Homma, Takafumi Kumamoto, Kazuhisa Takeda, Daisuke Morioka, Jiro Maegawa, Itaru Endo
PURPOSE: The aim of this study was to assess the efficacy of combined resection and reconstruction (CRR) of the hepatic artery (HA) in surgery for hilar cholangiocarcinoma (HC). MATERIALS AND METHOD: Among 172 patients who underwent surgical resection for HC, the following three groups were defined according to the type of vascular reconstruction: VR(-) group, in which neither CRR of the portal vein (PV) nor HA was performed (n = 74); VR-PV group, in which only CRR of the PV was required (n = 54); and VR-A group, in which CRR of the HA was performed either with or without CRR of the PV (n = 44)...
July 7, 2016: Annals of Surgical Oncology
Alexandra Albertsson-Lindblad, Arne Kolstad, Anna Laurell, Riikka Räty, Kirsten Grønbæk, Jan Sundberg, Lone Bredo Pedersen, Elisabeth Ralfkiær, Marja-Liisa Karjalainen-Lindsberg, Christer Sundström, Mats Ehinger, Christian Geisler, Mats Jerkeman
For elderly patients with mantle cell lymphoma (MCL), there is no defined standard therapy. In this multicenter open-label phase I/II trial we evaluated the addition of lenalidomide (LEN) to rituximab-bendamustine (R-B) as first-line treatment to elderly MCL patients. Patients >65 years with untreated MCL, stage II-IV were eligible for inclusion. Primary endpoints were maximally tolerable dose (MTD) of LEN, and progression-free survival (PFS). Patients received six cycles q4w of L-B-R (L D1-14, B 90 mg/m(2) iv D1-2 and R 375 mg/m(2) iv D1) followed by single LEN (D1-21, q4w, cycles 7-13)...
June 27, 2016: Blood
Lu Wang, Yinan Sun, Ben Zhao, Huixian Zhang, Qianqian Yu, Xianglin Yuan
OBJECTIVES: To evaluate the safety and efficiency of the conversion therapy : chemotherapy plus anti-epidermal growth factor Receptor (EGFR) or anti-vascular endothelial growth factor receptor (VEGFR) monoclonal antibodies (MoAbs) with different rat sarcoma (RAS) status in patients with potentially resectable colorectal liver metastases (CRLM). METHODS: Randomized controlled trials (RCTs) were identified and the association between RAS mutation and clinical outcome in CRLM patients treated with anti-EGFR or anti-VEGFR MoAbs was investigated...
May 27, 2016: Oncotarget
G N Nikhil, Dileep Kumar Yeruva, S Venkata Mohan, Y V Swamy
The present study evaluates relative functioning of microbial electrochemical systems (MES) for simultaneous wastewater treatment, desalination and resource recovery. Two MES were designed having abiotic cathode (MES-A) and algal biocathode (MES-B) which were investigated with synthetic feed and saline water as proxy of typical real-field wastewater. Comparative anodic and cathodic efficiencies revealed a distinct disparity in both the MES when operated in open circuit (OC) and closed circuit (CC). The maximum open circuit voltage (OCV) read in MES-A and MES-B was about 700mV and 600mV, respectively...
September 2016: Bioresource Technology
F Patti, S Messina, C Solaro, M P Amato, R Bergamaschi, S Bonavita, R Bruno Bossio, V Brescia Morra, G F Costantino, P Cavalla, D Centonze, G Comi, S Cottone, M Danni, A Francia, A Gajofatto, C Gasperini, A Ghezzi, A Iudice, G Lus, G T Maniscalco, M G Marrosu, M Matta, M Mirabella, E Montanari, C Pozzilli, M Rovaris, E Sessa, D Spitaleri, M Trojano, P Valentino, M Zappia
BACKGROUND: The approval of 9-δ-tetrahydocannabinol and cannabidiol (THC:CBD) oromucosal spray (Sativex) for the management of treatment-resistant multiple sclerosis (MS) spasticity opened a new opportunity for many patients. The aim of our study was to describe Sativex effectiveness and adverse events profile in a large population of Italian patients with MS in the daily practice setting. METHODS: We collected data of all patients starting Sativex between January 2014 and February 2015 from the mandatory Italian medicines agency (AIFA) e-registry...
September 2016: Journal of Neurology, Neurosurgery, and Psychiatry
Norimitsu Yabusaki, Tsutomu Fujii, Suguru Yamada, Kojiro Suzuki, Hiroyuki Sugimoto, Mitsuro Kanda, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera
BACKGROUND: Skeletal muscle depletion predicts poor prognosis of patients with certain cancers. However, the correlation between low skeletal muscle index (SMI) and the prognosis of hepatocellular carcinoma (HCC) is not well understood. METHODS: To determine their influence on prognosis, skeletal muscle index (SMI) and visceral fat area (VFA) were measured using computed tomography at the level of the third lumbar vertebra of 195 patients who underwent primary hepatectomy for hepatocellular carcinoma (HCC)...
May 4, 2016: International Journal of Surgery
Maria Magdalena Tomasiak-Lozowska, Tomasz Rusak, Tomasz Misztal, Anna Bodzenta-Lukaszyk, Marian Tomasiak
OBJECTIVE: Asthma enhances the risk of pulmonary embolism. The mechanism of this phenomenon is unclear. METHODS: We evaluated the kinetics of clot formation, clot retraction rate (CRR), clot volume at 40 min, the rate of lactate production (a marker of aerobic glycolysis in platelets in contracting clots), blood eosinophil count (EOS), nitric oxide in exhaled breath (FENO), and spirometry (FEV1) in 50 healthy controls and in 81 allergic asthmatics (41 subjects with steroid-naïve asthma and 40 with steroid-treated asthma)...
August 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Hyun-Tae Kim, Miao Yu
We report a cascaded ring resonator (CRR) based, silicon photonic temperature sensor for simultaneous sensitivity and range enhancement. To achieve the dual enhancement, the proposed CRR temperature sensor employs two micro ring resonators with different temperature sensitivities and different free spectral ranges (FSRs). The differences in the temperature sensitivities and FSRs are obtained by tailoring the in-plane geometric parameters of the two ring resonators. The CRR temperature sensor was fabricated by using a single-mask complementary metal-oxide-semiconductor (CMOS)-compatible process...
May 2, 2016: Optics Express
Fergus P McCarthy, Adedamola Adetoba, Carolyn Gill, Kate Bramham, Maria Bertolaccini, Graham J Burton, Guillermina Girardi, Paul T Seed, Lucilla Poston, Lucy C Chappell
BACKGROUND: Congophilia indicates the presence of amyloid protein, which is an aggregate of misfolded proteins, that is implicated in the pathophysiologic condition of preeclampsia. Recently, urinary congophilia has been proposed as a test for the diagnosis and prediction of preeclampsia. OBJECTIVES: The purpose of this study was to determine whether urine congophilia is present in a cohort of women with preeclampsia and in pregnant and nonpregnant women with renal disease...
October 2016: American Journal of Obstetrics and Gynecology
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