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Rohit A Gupta, Meha N Motiwala, Ujawala N Mahajan, Sapna S Sabare
ETHNOPHARMACOLOGICAL RELEVANCE: The plant Sesbania grandiflora (Linn) belonging to the family Fabaceae is commonly known as sesbania, agathi, and katurai. The plant is accredited for alleviating a spectrum of ailments including inflammation, colitis, diarrhea, dysentery, leprosy, gout, rheumatism, jaundice, bronchitis, convulsion and anxiety. It is also used as antitumour, anthelmintic, and laxatives in Ayurveda and Siddha system of Indian traditional medicine. AIM: To reveal protective effect of Sesbania grandiflora in acetic acid induced ulcerative colitis in mice...
March 9, 2018: Journal of Ethnopharmacology
Supranee Phanthanawiboon, Sabar Pambudi, Magot Diata Omokoko, Keiko Hanabara, Atchareeya A-Nuegoonpipat, Wataru Kamitani, Kazuyoshi Ikuta, Takeshi Kurosu
Producing virus at high yield is critically important for development of whole virion inactivated vaccines or live attenuated vaccines. Most dengue virus (DENV) clinical isolates, however, replicate at low levels in cultured cells, which limits their use for vaccine development. The present study examined differences between low-replicating DENV clinical isolates and high-replicating laboratory strains with the aim of engineering high-yield DENV clinical isolates. Construction of a series of recombinant chimeric viruses derived from a high-replicating laboratory DENV type 4 (DENV-4) H241 strain and a clinical isolate revealed that the NS3-NS4B region of H241 conferred a replication advantage in cultured cells...
January 1, 2018: Biochemical and Biophysical Research Communications
Aman Imran, Hafiza Yasara Qamar, Qurban Ali, Hafsa Naeem, Mariam Riaz, Saima Amin, Naila Kanwal, Fawad Ali, Muhammad Farooq Sabar, Idrees Ahmad Nasir
Background: Cancer is a genetic disease and mainly arises due to a number of reasons include activation of onco-genes, malfunction of tumor suppressor genes or mutagenesis due to external factors. Methods: This article was written from the data collected from PubMed, Nature, Science Direct, Springer and Elsevier groups of journals. Results: Oncogenes are deregulated form of normal proto-oncogenes required for cell division, differentiation and regulation...
November 2017: Iranian Journal of Public Health
Narges Shahbazi, Ehsan Mostafavi
No abstract text is available yet for this article.
January 1, 2018: Iranian Biomedical Journal
Muhammad Iftikhar Sabar, Abhay Bajpai, Aziz Momin, Riyaz A Kaba
Lasso catheter (Biosense Webster) is one of the most commonly employed circular mapping catheters during pulmonary vein isolation (PVI) procedure for atrial fibrillation (AF). Although this catheter has greatly facilitated arrhythmia mapping, it can be associated with serious complications. We report a case of a 59-year-old man who underwent PVI procedure for persistent AF. During the procedure, the Lasso catheter inadvertently slipped into the left ventricular cavity and entangled in the mitral valve apparatus...
October 25, 2017: BMJ Case Reports
Muhammad Khalid Mansoor, Abdullmajeed Hamood Al-Rawahi, Hatim Ali El-Tahir, Badar Al-Faraei, Muhammad Hammad Hussain, Muhammad Nadeem Asi, Ibrahim Al-Hussani, Safwat Sabar
Foot and mouth disease (FMD) remains subclinical and self-limiting in small ruminants, but risk of spread of infection to susceptible cohorts is of great epidemiological significance; therefore, small ruminants must be included in vaccination campaigns in FMD endemic regions. Three groups of goats already immunized against peste des petits ruminants (PPR) were vaccinated with FMD and PPR vaccines alone or concurrently. The specific antibody response against three FMD virus strains and PPR virus were evaluated by competitive enzyme-linked immunosorbent assay (cELISA)...
January 2018: Tropical Animal Health and Production
Mohd Fahmi Mohd Yusof, Puteri Nor Khatijah Abd Hamid, Abd Aziz Tajuddin, Rokiah Hashim, Sabar Bauk, Norriza Mohd Isa, Muhammad Jamal Md Isa
The aim of this study was to determine the suitability of tannin-added Rhizophora spp. particleboards as phantom materials in the application of low- and high-energy photons. The tannin-added Rhizophora spp. particleboards and density plug phantoms were created with a target density of 1.0 g/cm3 . The elemental composition and effective atomic number of the particleboards were measured using energy dispersive X-ray analysis. The mass attenuation coefficient of the particleboards for low-energy photons were measured using the attenuation of X-ray fluorescence...
September 2017: Radiological Physics and Technology
Sabar D Hutagalung, Mohammed M Fadhali, Raed A Areshi, Fui D Tan
Silicon nanowires (SiNWs) were fabricated by the electroless etching of an n-type Si (100) wafer in HF/AgNO3. Vertically aligned and high-density SiNWs are formed on the Si substrates. Various shapes of SiNWs are observed, including round, rectangular, and triangular. The recorded maximum reflectance of the SiNWs is approximately 19.2%, which is much lower than that of the Si substrate (65.1%). The minimum reflectance of the SiNWs is approximately 3.5% in the near UV region and 9.8% in the visible to near IR regions...
December 2017: Nanoscale Research Letters
Afia Muhammad Akram, Zafar Iqbal, Tanveer Akhtar, Ahmed Mukhtar Khalid, Muhammad Farooq Sabar, Mahmood Hussain Qazi, Zeba Aziz, Nadia Sajid, Aamer Aleem, Mahmood Rasool, Muhammad Asif, Saleh Aloraibi, Khaled Aljamaan, Mudassar Iqbal
BCR-ABL kinase domain (KD) mutations are well known for causing resistance against tyrosine kinase inhibitors (TKIs) and disease progression in chronic myeloid leukemia (CML). In recent years, compound BCR-ABL mutations have emerged as a new threat to CML patients by causing higher degrees of resistance involving multiple TKIs, including ponatinib. However, there are limited reports about association of compound BCR-ABL mutations with disease progression in imatinib (IM) sensitive CML patients. Therefore, we investigated presence of ABL-KD mutations in chronic phase (n = 41), late chronic phase (n = 33) and accelerated phase (n = 16) imatinib responders...
April 3, 2017: Cancer Biology & Therapy
Nelly Badalato, Alain Guillot, Victor Sabarly, Marc Dubois, Nina Pourette, Bruno Pontoire, Paul Robert, Arnaud Bridier, Véronique Monnet, Diana Z Sousa, Sylvie Durand, Laurent Mazéas, Alain Buléon, Théodore Bouchez, Gérard Mortha, Ariane Bize
Lignocellulosic materials from municipal solid waste emerge as attractive resources for anaerobic digestion biorefinery. To increase the knowledge required for establishing efficient bioprocesses, dynamics of batch fermentation by the cellulolytic bacterium Ruminiclostridium cellulolyticum were compared using three cellulosic materials, paper handkerchief, cotton discs and Whatman filter paper. Fermentation of paper handkerchief occurred the fastest and resulted in a specific metabolic profile: it resulted in the lowest acetate-to-lactate and acetate-to-ethanol ratios...
2017: PloS One
Muhammad Farooq Sabar, Mariam Shahid, Iqbal Bano, Muhammad Usman Ghani, Muhammad Akram, Farheena Iqbal, Samra Kousar, Zafar Iqbal, Saba Altaf, Tayyab Husnain
OBJECTIVE: rs12603332, an important regulatory site variant, is known to alter the regulatory motif E2A that is involved in the maturation of B-lymphocytes. The study was designed to check whether different environmental exposures alter its risk allele association with asthma or not. METHODS: 200 Physician-diagnosed asthma patients and 108 healthy individuals were enrolled from hospitals of Lahore. After quantitation of DNA extracted from peripheral blood, amplification of genomic region with rs12603332, followed by single base extension (SBE), was performed...
November 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Djalal Trache, M Hazwan Hussin, Caryn Tan Hui Chuin, Sumiyyah Sabar, M R Nurul Fazita, Owolabi F A Taiwo, T M Hassan, M K Mohamad Haafiz
Considering its widespread usage in various fields, such as food, pharmaceutical, medical, cosmetic and polymer composites industries, microcrystalline cellulose (MCC) is becoming impellent due to increasing demand of alternatives to non-renewable and scarce fossil materials. Although it still suffers from some drawbacks, MCC has recently gained more interest owing to its renewability, non-toxicity, economic value, biodegradability, high mechanical properties, high surface area and biocompatibility. New sources, new isolation processes, and new treatments are currently under development to satisfy the increasing demand of producing new types of MCC-based materials on an industrial scale...
December 2016: International Journal of Biological Macromolecules
N Majumder
The study has been conducted in the Potka Block of East Singhbhum district of the state of Jharkhand. The district is mainly dominated by indigenous tribes, such as, Santhal, Munda, Ho, Bhumiz, Kharia, and Sabar. The unit of analysis of the study was an individual. The objectives were to: a) Understand the socio-economic and health status of LAP, b) Know the health seeking behavior and problems faced by the LAP, c) Assess the utilization of the programs related to Leprosy eradication in the study area and d), Suggest various measures for improving the socio-economic and health status of LAP...
July 2015: Indian Journal of Leprosy
Zafar Iqbal, Tanveer Akhtar, Tashfin Awan, Aamer Aleem, Noreen Sabir, Mahmood Rasool, Muhammad Absar, Afia M Akram, Masood A Shammas, Ijaz H Shah, Muhammad Khalid, Abid S Taj, Abid Jameel, Abdullah Alanazi, Ammara T Gill, Jamil Amjad Hashmi, Akhtar Hussain, Muhammad Farooq Sabar, Ahmad M Khalid, Mehmood Hussain Qazi, Sajjad Karim, Muhammad Hassan Siddiqi, Aamir Mahmood, Mudassar Iqbal, Anjum Saeed, Muhammad Imran Irfan
BACKGROUND: Fusion oncogenes (FOs) resulting from chromosomal abnormalities have an important role in leukemogenesis in pediatric B cell acute lymphoblastic leukemia (ALL). The most common FOs are BCR-ABL, MLL-AF4, ETV6-RUNX1, and TCF3-PBX1, all of which have important prognostic and drug selection implications. Moreover, frequencies of FOs have ethnic variations. We studied Pakistani frequencies of FOs, clinical pattern, and outcome in pediatric B-ALL. METHODS: FOs were studied in 188 patients at diagnosis using reverse transcriptase-polymerase chain reaction (RT-PCR) and interphase fluorescent in situ hybridization (FISH)...
October 2015: Molecular Diagnosis & Therapy
Mariam Shahid, Muhammad Farooq Sabar, Iqbal Bano, Ziaur Rahman, Zafar Iqbal, Sayyeda Saadia Fatim Ali, Muhammad Usman Ghani, Muhammad Iqbal, Tayyab Husnain
OBJECTIVE: Single nucleotide polymorphisms (SNPs) on 17q21 are known to be associated with asthma disease in multiple populations. This study was designed to know whether this region is associated with asthma in Lahore region population or not. METHODS: A total of 200 asthma patients and 100 healthy controls were enrolled from different hospitals of Lahore, Pakistan. Twelve SNPs from chromosomal region 17q21 were analyzed in cases and controls by single base extension method and capillary-based genetic analyzers...
October 2015: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Kashif Ur Rehman, Tanveer Akhtar, Muhammad Farooq Sabar, Muhammad Akram Tariq
Drug resistance is a phenomenon that has become a critical issue in medical practice. Such is the case in the response to clopidogrel treatment, which is variable inter-individually and inter-ethnically due to genetic polymorphisms in the cytochrome P40 (CYP) gene. Clopidogrel is an anti-platelet agent administered to cardiac patients in the form of a prodrug, which is further metabolized into an active form by CYP enzymes. There are many allelic variants of the CYP gene that are involved in clopidogrel resistance, of which CYP2C19*2 has been demonstrated to be one of the most significant loss-of-function alleles...
July 2015: Experimental and Therapeutic Medicine
Victor Sabarly, Cécile Aubron, Jérémy Glodt, Thierry Balliau, Olivier Langella, Didier Chevret, Odile Rigal, Aurélie Bourgais, Bertrand Picard, Dominique de Vienne, Erick Denamur, Odile Bouvet, Christine Dillmann
To gain insights into the adaptation of the Escherichia coli species to different environments, we monitored protein abundances using quantitative proteomics and measurements of enzymatic activities of central metabolism in a set of five representative strains grown in four contrasted culture media including human urine. Two hundred and thirty seven proteins representative of the genome-scale metabolic network were identified and classified into pathway categories. We found that nutrient resources shape the general orientation of metabolism through coordinated changes in the average abundances of proteins and in enzymatic activities that all belong to the same pathway category...
January 2016: Environmental Microbiology
Michael Silbermann, Regina M Fink, Sung-Joon Min, Mary P Mancuso, Jeannine Brant, Ramzi Hajjar, Nesreen Al-Alfi, Lea Baider, Ibrahim Turker, Karima ElShamy, Ibtisam Ghrayeb, Mazin Al-Jadiry, Khaled Khader, Sultan Kav, Haris Charalambous, Ruchan Uslu, Rejin Kebudi, Gil Barsela, Nilgün Kuruku, Kamer Mutafoglu, Gulsin Ozalp-Senel, Amitai Oberman, Livia Kislev, Mohammad Khleif, Neophyta Keoppi, Sophia Nestoros, Rasha Fahmi Abdalla, Maryam Rassouli, Amira Morag, Ron Sabar, Omar Nimri, Mohammad Al-Qadire, Murad Al-Khalaileh, Mona Tayyem, Myrna Doumit, Rehana Punjwani, Osaid Rasheed, Fatimah Fallatah, Gulbeyaz Can, Jamila Ahmed, Debbie Strode
BACKGROUND: Cancer incidence in Middle Eastern countries, most categorized as low- and middle-income, is predicted to double in the next 10 years, greater than in any other part of the world. While progress has been made in cancer diagnosis/treatment, much remains to be done to improve palliative care for the majority of patients with cancer who present with advanced disease. OBJECTIVE: To determine knowledge, beliefs, barriers, and resources regarding palliative care services in Middle Eastern countries and use findings to inform future educational and training activities...
January 2015: Journal of Palliative Medicine
Sabina Wangui Wachira, Sabar Omar, Julia Wanjiru Jacob, Martin Wahome, Hans T Alborn, David R Spring, Daniel K Masiga, Baldwyn Torto
BACKGROUND: The African malaria vector, Anopheles gambiae s.s., is known to feed selectively on certain plants for sugar sources. However, the adaptive significance of this behaviour especially on how the extracts of such plants impact on the fitness of this vector has not been explored. This study determined the toxicity and larvicidal activity on this vector of extracts from six selected plants found in Kenya and two compounds identified from Ricinus communis: 3-carbonitrile-4-methoxy-N-methyl-2-pyridone (ricinine), and its carboxylic acid derivative 3-carboxy-4-methoxy-N-methyl-2-pyridone, the latter compound being reported for the first time from this plant...
July 4, 2014: Parasites & Vectors
Nasser R Sabar, Masri Ayob, Graham Kendall, Rong Qu
Hyper-heuristics are search methodologies that aim to provide high-quality solutions across a wide variety of problem domains, rather than developing tailor-made methodologies for each problem instance/domain. A traditional hyper-heuristic framework has two levels, namely, the high level strategy (heuristic selection mechanism and the acceptance criterion) and low level heuristics (a set of problem specific heuristics). Due to the different landscape structures of different problem instances, the high level strategy plays an important role in the design of a hyper-heuristic framework...
February 2015: IEEE Transactions on Cybernetics
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