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Timo Siepmann, Kristian Barlinn, Ana Isabel Penzlin, Ben M W Illigens, Hagen Kitzler, Ulf Bodechtel
BACKGROUND: Cortical lesions in status epilepticus have been reported but the underlying mechanisms are poorly elucidated. CASE SUMMARY: We report on afemale patient (75 years) with a history of alcohol abuse who presented with complex partial status epilepticus and lateralized epileptiform discharges in the left frontal and temporal regions in EEG. While cranial magnetic resonance imaging (MRI) showed left hippocampal T2-hyperintensity and diffusion restriction, cerebrospinal fluid was normal and revealed no limbic encephalitis-related antibodies...
December 2015: Neurodiagnostic Journal
Marco Loffi, Laura Toffetti, Carola Gianni, Federico Lombardi
No abstract text is available yet for this article.
July 2015: Journal of Cardiovascular Electrophysiology
Huichao Zou, Samuel W Brayer, Maxwell Hurwitz, Christian Niyonkuru, Lorraine E Fowler, Amy K Wagner
BACKGROUND: Prophylactic treatment with antiepileptic drugs (AEDs) has been recommended to prevent early seizure onset in patients with traumatic brain injury (TBI). However, the potential neuroprotective and/or detrimental effects of prophylactic AED treatment on behavioral and cognitive function after TBI are not well studied. OBJECTIVE: To investigate the effects of a novel AED, levitiracetam (LEV), on behavioral and cognitive function after experimental TBI in rats...
November 2013: Neurorehabilitation and Neural Repair
Ludivine Orriols, Alexandra Foubert-Samier, Blandine Gadegbeku, Bernard Delorme, Aurore Tricotel, Pierre Philip, Nicholas Moore, Emmanuel Lagarde
Studies assessing the impact of epilepsy and its medication on the risk of road traffic crashes have shown inconsistent results. The aim in this study was to assess this risk using French databases. Data from three French national databases were extracted and matched: the national health care insurance database, police reports, and the national police database of injurious crashes. Only antiepileptics prescribed predominantly in epilepsy were studied (phenobarbital, phenytoin, ethosuximide, valproic acid, vigabatrin, tiagabin, levitiracetam, zonisamide, and lacosamide)...
March 2013: Journal of Clinical Pharmacology
Roberto Cordella, Francesco Acerbi, Carlo Efisio Marras, Carla Carozzi, Davide Vailati, Marco Saini, Giovanni Tringali, Paolo Ferroli, Francesco Dimeco, Angelo Franzini, Giovanni Broggi
Tumours close to cerebral cortices involved in motor and language functions represent a major challenge for neurosurgeons. Intraoperative neurophysiologic monitoring is useful to gain insight into the anatomy of and the relationship between pathological and normal tissues. In this study we report on the experience of electrocortical stimulation in the surgery of tumours adjacent to the motor cortex in 50 patients under general anaesthesia (26 under propofol, 24 under sevoflurane), and on EMG responses from contralateral muscles...
January 2013: Neurological Sciences
I G Rudakova, O S Morozova, A S Kotov
The purpose of the study was the comparative evaluation of antiepileptic drugs (AED) impact on quality of life (QOL). One hundred and ninety-two patients with symptomatic and probably symptomatic focal epilepsies (mean age 30, 6 +/- 1.05) were investigated. All patients received the following AED as monotherapy: valproate (52), carbamazepine (36), topiramate (56), levitiracetam (24), oxcarbazepine (24). The clinical and neurological examination, EEG and/or video-EEG-monitoring, CT and/ or MRA scan, neuropsychological tests (31-item Quality of Life in Epilepsy--QOLIE-31, version 1 and HUDS) were performed after 3 months of treatment...
2008: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Jeffrey F Wade, Chat V Dang, Lowell Nelson, Jonathan Wasserberger
BACKGROUND: Multiple new anticonvulsants have been introduced recently and they are supplanting the older medications. Whereas the older drugs have well-recognized side effects, both in typical therapeutic doses and in overdosage, the properties of the newer ones are unique and largely unknown to all but sub-specialists. OBJECTIVES: This article gives a concise overview of the potential complications of these new medications in both therapeutic use and overdose...
February 2010: Journal of Emergency Medicine
E Niedermeyer, Adrian Goldszmidt, Dawn Ryan
Rolandic mu rhythm is usually limited to brief stretches of 0.5 to 2 sec duration. Two observations of status-like enhancement of mu rhythm have prompted this report. In both cases, 4-hour EEG-Video-Monitoring was used. Clinically, the reported cases differed considerably. Case 1 showed nearly continuous mu activity associated with general motionlessness: akinesia/amimia but without rigidity, caused by frontal lobe impairment due to multiple sclerosis. In Case 2, an impressive mu-status started in drowsiness and was presumably attributable to levitiracetam (which had rendered seizure-free the patient's formerly severe case of temporal lobe epilepsy)...
April 2004: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
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