keyword
MENU ▼
Read by QxMD icon Read
search

Bowel disease

keyword
https://www.readbyqxmd.com/read/29656116/chromogranin-a-and-its-derived-peptides-and-their-pharmacological-effects-during-intestinal-inflammation
#1
REVIEW
Nour Eissa, Hayam Hussein, Geoffrey N Hendy, Charles N Bernstein, Jean-Eric Ghia
The gastrointestinal tract is the largest endocrine organ that produces a broad range of active peptides. Mucosal changes during inflammation alter the distribution and products of enteroendocrine cells (EECs) that play a role in immune activation and regulation of gut homeostasis by mediating communication between the nervous, endocrine and immune systems. Patients with inflammatory bowel disease (IBD) typically have altered expression of chromogranin (CHG)-A (CHGA), a major soluble protein secreted by EECs that functions as a pro-hormone...
April 12, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29655972/effectiveness-and-safety-of-anti-tnf-therapy-for-inflammatory-bowel-disease-in-liver-transplant-recipients-for-primary-sclerosing-cholangitis-a-nationwide-case-series
#2
Romain Altwegg, Roman Combes, David Laharie, Victor De Ledinghen, Sylvie Radenne, Filomena Conti, Olivier Chazouilleres, Christophe Duvoux, Jérôme Dumortier, Vincent Leroy, Xavier Treton, François Durand, Sébastien Dharancy, Maria Nachury, Félix Goutorbe, Géraldine Lamblin, Lucile Boivineau, Laurent Peyrin-Biroulet, Georges-Philippe Pageaux
BACKGROUND: There is a lack of consensus regarding the treatment of inflammatory bowel disease (IBD) after liver transplantation (LT) forprimary sclerosing cholangitis (PSC). AIM: To investigate the safety and effectiveness of anti-TNF therapy in patients with IBD after a LT for PSC. METHODS: We reviewed the medical files of all of the IBD patients who underwent a LT for PSC and who were treated with anti-TNF therapy at 23 French liver transplantation centers between 1989 and 2012...
March 13, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29655835/risk-of-serious-and-opportunistic-infections-associated-with-treatment-of-inflammatory-bowel-diseases
#3
Julien Kirchgesner, Magali Lemaitre, Fabrice Carrat, Mahmoud Zureik, Md Franck Carbonnel, Rosemary Dray-Spira
BACKGROUND & AIMS: The risk of infection associated with tumor necrosis factor antagonists (anti-TNF) and thiopurines (combination therapy) is uncertain. We assessed the risk of serious and opportunistic infections in patients with IBD treated with thiopurine monotherapy, anti-TNF monotherapy, or combination therapy in a large cohort of patients in France. METHODS: We performed a nationwide population-based study of patients (18 years or older) with a diagnosis of IBD in the French national health insurance database; we collected data from January 1, 2009 until December 31, 2014...
April 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29655556/in-vitro-bioassessment-of-the-immunomodulatory-activity-of-saccharomyces-cerevisiae-components-using-bovine-macrophages-and-mycobacterium-avium-ssp-paratuberculosis
#4
Z Li, H Kang, Q You, F Ossa, P Mead, M Quinton, N A Karrow
The yeast Saccharomyces cerevisiae and its components are used for the prevention and treatment of enteric disease in different species; therefore, they may also be useful for preventing Johne's disease, a chronic inflammatory bowel disease of ruminants caused by Mycobacterium avium ssp. paratuberculosis (MAP). The objective of this study was to identify potential immunomodulatory S. cerevisiae components using a bovine macrophage cell line (BOMAC). The BOMAC phagocytic activity, reactive oxygen species production, and immune-related gene (IL6, IL10, IL12p40, IL13, IL23), transforming growth factor β, ARG1, CASP1, and inducible nitric oxide synthase expression were investigated when BOMAC were cocultured with cell wall components from 4 different strains (A, B, C, and D) and 2 forms of dead yeast from strain A...
April 11, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29655368/spontaneous-posterior-rectus-sheath-hernia-a-case-report
#5
Chu Woon Ng, Anna Sandstrom, Grace Lim
BACKGROUND: Hernias of the posterior rectus sheath are very rare abdominal wall hernias with only a handful of cases reported in the literature to date. As an uncommon disease, it is important to recognize and report this case in order to enhance scientific knowledge of this disease. CASE PRESENTATION: This case report presents a spontaneous posterior rectus sheath herniation in a 79-year-old white man with previous abdominal surgery for appendicitis. His herniation was discovered incidentally during an examination for his chief complaints of lower abdominal pain and diarrhea which were later diagnosed as Salmonella-related gastroenteritis...
April 15, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29653290/paternal-disease-activity-is-associated-with-difficulty-in-conception-among-men-with-inflammatory-bowel-diseases
#6
Ashwin N Ananthakrishnan, Christopher Martin, Sunanda Kane, Robert S Sandler, Millie D Long
No abstract text is available yet for this article.
April 10, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29653213/neutrophilic-dermatoses-part-ii-pyoderma-gangrenosum-and-other-bowel-and-arthritis-associated-neutrophilic-dermatoses
#7
REVIEW
Hovik J Ashchyan, Caroline A Nelson, Sasha Stephen, William D James, Robert G Micheletti, Misha Rosenbach
Neutrophilic dermatoses are a heterogeneous group of inflammatory skin disorders that present with unique clinical features, but are unified by the presence of a sterile, predominantly neutrophilic infiltrate on histopathology. The morphology of cutaneous lesions associated with these disorders is heterogeneous, which renders diagnosis challenging. Moreover, a thorough evaluation is required to exclude diseases that mimic these disorders and to diagnose potential associated infectious, inflammatory, and neoplastic processes...
April 10, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29653092/cd10-inhibits-cell-motility-but-expression-is-associated-with-advanced-stage-disease-in-colorectal-cancer
#8
Teresa P Raposo, Mireia Sueca Comes, Adeyemi Idowu, Bora Agit, James Hassall, Wakkas Fadhil, Robert Nica, Rupert Ecker, Takashi Yao, Mohammad Ilyas
INTRODUCTION: CD10 is a cell membrane-bound endopeptidase which is expressed in normal small bowel but not in normal colon. It is aberrantly expressed in a small proportion of colorectal cancers (CRC) and this has been associated with liver metastasis and poor prognosis. We sought to investigate the mechanism of CD10 activity and its association with clinicopathological features. MATERIAL AND METHODS: CD10 was stably knocked down by lentiviral shRNA transduction in the CRC cell lines SW480 and SW620 which are derived from a primary tumour and its corresponding metastasis respectively...
April 10, 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29652832/sympathetic-nerve-hyperactivity-in-the-spleen-causal-for-nonpathogenic-driven-chronic-immune-mediated-inflammatory-diseases-imids
#9
REVIEW
Denise L Bellinger, Dianne Lorton
Immune-Mediated Inflammatory Diseases (IMIDs) is a descriptive term coined for an eclectic group of diseases or conditions that share common inflammatory pathways, and for which there is no definitive etiology. IMIDs affect the elderly most severely, with many older individuals having two or more IMIDs. These diseases include, but are not limited to, type-1 diabetes, obesity, hypertension, chronic pulmonary disease, coronary heart disease, inflammatory bowel disease, and autoimmunity, such as rheumatoid arthritis (RA), Sjőgren's syndrome, systemic lupus erythematosus, psoriasis, psoriatic arthritis, and multiple sclerosis...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29652728/intestinal-microbiota-in-hirschsprung-disease
#10
Malla I Neuvonen, Katri Korpela, Kristiina Kyrklund, Risto J Rintala, Mikko P Pakarinen
OBJECTIVES: To characterize the microbiota profiles of patients with Hirschsprung's disease (HD), and to evaluate this in relation to postoperative bowel function and the incidence of Hirschsprung-associated enterocolitis (HAEC). METHODS: All patients operated on for HD at our center between 1987-2011 were invited to answer questionnaires on bowel function and to participate in a clinical follow-up for laboratory investigations, including fecal DNA extraction, fecal calprotectin (FC), and brush border lactase (LCT) genotyping...
April 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29652549/prolonged-granulocyte-colony-stimulating-factor-use-in-glycogen-storage-disease-type-1b-associated-with-acute-myeloid-leukemia-and-with-shortened-telomere-length
#11
Amanda M Li, Santhosh Thyagu, Dawn Maze, Richard Schreiber, Sandra Sirrs, Sylvia Stockler-Ipsiroglu, Heather Sutherland, Suzanne Vercauteren, Kirk R Schultz
Glycogen storage disease (GSD) type 1 is a rare autosomal recessive inherited condition. The 1b subtype comprises the minority of cases, with an estimated prevalence of 1 in 500,000 children. Patients with glycogen storage disease type 1b are often treated with granulocyte colony stimulating factor (G-CSF) for prolonged periods to improve symptoms of inflammatory bowel disease (IBD) and in the face of severe neutropenia to decrease risk of infection. Long-term G-CSF treatment may result in an increased risk of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) possibly due to increased marrow stress resulting in telomere shortening...
April 13, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29651607/detecting-inflammation-in-inflammatory-bowel-disease-how-does-ultrasound-compare-to-magnetic-resonance-enterography-using-standardised-scoring-systems
#12
Joy L Barber, Alexsandra Zambrano-Perez, Øystein E Olsen, Fevronia Kiparissi, Mila Baycheva, Daniela Knaflez, Neil Shah, Tom A Watson
BACKGROUND: Magnetic resonance enterography (MRE) is the current gold standard for imaging in inflammatory bowel disease, but ultrasound (US) is a potential alternative. OBJECTIVE: To determine whether US is as good as MRE for the detecting inflamed bowel, using a combined consensus score as the reference standard. MATERIALS AND METHODS: We conducted a retrospective cohort study in children and adolescents <18 years with inflammatory bowel disease (IBD) at a tertiary and quaternary centre...
April 13, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29650827/-a-case-report-of-complete-resection-of-the-recurrence-small-intestinal-carcinoma-with-abdominal-wall-repair-using-femoral-fascia
#13
Tadafumi Fukata, Taishi Hata, Tateki Kubo, Naotsugu Haraguchi, Hidekazu Takahashi, Junichi Nishimura, Chu Matsuda, Tsunekazu Mizushima, Kou Hosokawa, Yuichiro Doki, Masaki Mori
The patients had Hartmann's operation for rectal cancer when she was 61 years old. After that, she underwent the operation for small bowel cancer when she was 68 years old. After 5 months, the only metastatic lesion was detected near the Scolon stoma. For the first therapy, She received chemotherapy(mFOLFOX6 plus bevacizumab)and had a reducing effect. She was introduced to our hospital for the purpose of resection of the recurrent lesion. CT scan detected a nodule near the Scolon stoma with FDG uptake for PET-CT scan...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650418/inflammatory-bowel-disease-drastically-affects-the-prognosis-of-patients-treated-for-peritoneal-metastases-with-combined-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-a-multicenter-study
#14
Nassim Hammoudi, Clarisse Eveno, Jérôme Lambert, Marianne Maillet, Olivier Glehen, Diane Goere, Nelson Lourenco, Matthieu Allez, Thomas Aparicio, Marc Pocard, Jean-Marc Gornet
BACKGROUND: Complete cytoreductive surgery (CCRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is a validated treatment in selected patients with peritoneal metastases (PM) of intestinal origin. There is an increased risk of Colorectal Cancer (CRC) and Small Bowel Adenocarcinoma (SBA) in Inflammatory Bowel Disease (IBD). The feasibility and benefit of that surgical approach in IBD patients is unknown. METHODS: IBD patients with operated PM complicating CRC or SBA were extracted from a French national multicenter prospective database of patients who underwent surgery for PM in HIPEC expert centers from 1995 to 2016...
March 17, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29649612/independent-predictors-of-spinal-epidural-abscess-recurrence
#15
Akash A Shah, Huiliang Yang, Paul T Ogink, Joseph H Schwab
BACKGROUND CONTEXT: Recurrence of spinal epidural abscess (SEA) after treatment is an important cause of continued morbidity for patients. PURPOSE: The purpose of this study is to identify independent predictors of recurrence of SEA. STUDY DESIGN/SETTING: This was a retrospective, case-control study. PATIENT SAMPLE: Patients 18 years or older with a diagnosis of SEA admitted to our hospital system during the study period were included in the study sample...
April 9, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29649328/association-between-kir-hla-combination-and-ulcerative-colitis-and-crohn-s-disease-in-a-japanese-population
#16
Hiromi Saito, Atsuhiro Hirayama, Takeji Umemura, Satoru Joshita, Kenji Mukawa, Tomoaki Suga, Eiji Tanaka, Masao Ota
Inflammatory bowel disease (IBD) consists of ulcerative colitis (UC) and Crohn's disease (CD). Natural killer cell responses play a crucial role in autoimmune disease through innate immunity, in which killer cell immunoglobulin-like receptors (KIRs) are closely involved. Although the genetic combination of KIRs with their specific HLA class I ligands has been associated with IBD in Caucasians, such KIR-HLA receptor-ligand combinations are not fully understood in the Japanese. We investigated 14 KIR genes along with HLA-Bw and -C ligands in 90 patients with UC and 50 patients with CD and compared them with the characteristics of 325 healthy control subjects...
2018: PloS One
https://www.readbyqxmd.com/read/29648663/incidence-and-classification-of-postcolonoscopy-colorectal-cancers-in-inflammatory-bowel-disease-a-dutch-population-based-cohort-study
#17
Dion S J Wintjens, Roel M M Bogie, Tim R A van den Heuvel, Chantal M C le Clercq, Liekele E Oostenbrug, Mariëlle J L Romberg-Camps, Jan-Willem Straathof, Laurents P S Stassen, Ad A M Masclee, Daisy M A E Jonkers, Silvia Sanduleanu-Dascalescu, Marie J Pierik
Background and Aims: Patients with inflammatory bowel disease (IBD) colitis are at increased risk for colorectal cancer (CRC). We examined the proportion and most likely aetiology of potentially preventable postcolonoscopy CRCs (PCCRCs) in a population-based cohort. Furthermore, adherence to IBD surveillance guidelines was evaluated in both PCCRCs and the remainder of prevalent CRCs. Methods: All IBD patients diagnosed from 1991 to 2011 in the South Limburg region of The Netherlands (i...
April 10, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29645077/a-symptom-based-model-to-predict-colorectal-cancer-in-low-resource-countries-results-from-a-prospective-study-of-patients-at-high-risk-for-colorectal-cancer
#18
Olusegun Isaac Alatise, Omobolaji O Ayandipo, Ademola Adeyeye, Ken Seier, Akinwunmi O Komolafe, Matthew O Bojuwoye, Oludapo O Afuwape, Ann Zauber, Adeleye Omisore, Samuel Olatoke, Adegboyega Akere, Olusola Famurewa, Mithat Gonen, David O Irabor, T Peter Kingham
BACKGROUND: Colorectal cancer (CRC) rates in low-resource countries, which typically lack CRC screening programs, are rising. This study determined whether a risk model for patients with rectal bleeding could identify patients with curable CRC. METHODS: This prospective, cross-sectional study evaluated a model constructed from data from 1 hospital and validated at 2 other hospitals. The primary endpoint was the ability of the model to predict CRC, as diagnosed by colonoscopy, from clinical characteristics...
April 12, 2018: Cancer
https://www.readbyqxmd.com/read/29644870/a-novel-polyphenolic-prebiotic-and-probiotic-formulation-have-synergistic-effects-on-the-gut-microbiota-influencing-drosophila-melanogaster-physiology
#19
Susan Westfall, Nikita Lomis, Satya Prakash
The gut microbiota is a vast community of synergistic bacterial species providing health benefits to the host. Imbalances in the gut microbiota (dysbiosis) due to diet, antibiotic use, age and stress contribute to disease development including diabetes, obesity, colon cancer, inflammatory bowel disease, inflammaging and neurodegeneration. Fortunately, a probiotic regime with a diet rich in prebiotics may reverse dysbiosis promoting health and wellness in age. The current study designs, optimizes and tests a novel probiotic and synbiotic formulation consisting of three metabolically active probiotics Lactobacillus plantarum, Lactobacillus fermentum and Bifidobacteria infantis together with a novel polyphenol-rich prebiotic, Triphala...
April 12, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29644739/editorial-monitoring-vedolizumab-trough-serum-concentration-in-inflammatory-bowel-disease-following-the-fate-of-anti-tnf-alpha-agents
#20
EDITORIAL
M Fragaki, K Karmiris
No abstract text is available yet for this article.
May 2018: Alimentary Pharmacology & Therapeutics
keyword
keyword
36741
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"