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Neuromyelitis optica

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https://www.readbyqxmd.com/read/29032462/association-of-tnfsf4-polymorphisms-with-neuromyelitis-optica-spectrum-disorders-in-a-chinese-population
#1
Zhiyun Lian, Ju Liu, Ziyan Shi, Hongxi Chen, Qin Zhang, Huiru Feng, Qin Du, Xiaohui Miao, Hongyu Zhou
The tumor necrosis factor ligand superfamily member 4 (TNFSF4) gene encodes a vital co-stimulatory molecule of the immune system and has been identified as a susceptibility locus for systemic lupus erythematosus, systemic sclerosis, and primary Sjögren's syndrome. However, the association of TNFSF4 polymorphisms with neuromyelitis optica spectrum disorders (NMOSD), an inflammatory, demyelinating autoimmune disease of the central nervous system, has not yet been investigated. To evaluate whether TNFSF4 polymorphisms contribute to risk of NMOSD, four single-nucleotide polymorphisms (SNPs) (rs1234315, rs2205960, rs704840, and rs844648) were selected and genotyped in a cohort of 312 patients with NMOSD and 487 healthy controls...
October 14, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29030768/diagnostics-of-the-neuromyelitis-optica-spectrum-disorders-nmosd
#2
REVIEW
Diego Franciotta, Matteo Gastaldi, Arianna Sala, Francesca Andreetta, Elena Rinaldi, Maddalena Ruggieri, Rosaria Leante, Gianna Costa, Tiziana Biagioli, Luca Massacesi, Elena Bazzigaluppi, Raffaella Fazio, Sara Mariotto, Sergio Ferrari, Elisabetta Galloni, Francesco Perini, Elisabetta Zardini, Luigi Zuliani, Marco Zoccarato, Bruno Giometto, Antonio Bertolotto
This document presents the guidelines for anti-aquaporin-4 (AQP4) antibody testing that has been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on neuromyelitis optica spectrum disorders, indications and limits of anti-AQP4 antibody testing, instructions for result interpretation, and an agreed laboratory protocol (Appendix) are reported for the communicative community of neurologists and clinical pathologists...
October 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29030418/short-delay-to-initiate-plasma-exchange-is-the-strongest-predictor-of-outcome-in-severe-attacks-of-nmo-spectrum-disorders
#3
Mickael Bonnan, Rudy Valentino, Stéphane Debeugny, Harold Merle, Jean-Louis Fergé, Hossein Mehdaoui, Philippe Cabre
INTRODUCTION: Severe attacks of neuromyelitis optica spectrum disorder (NMO-SD) are improved by plasma exchange (PLEX) given as an adjunctive therapy. Initial studies failed to demonstrate a delay of PLEX treatment influenced clinical outcome; however PLEX was always used late. We examine the clinical consequences of delay in PLEX initiation on severe optic neuritis and spinal cord attacks in NMO-SD. METHODS: All of our patients who suffered attacks of NMO-SD, treated in our centre by PLEX, were retrospectively considered for inclusion...
October 13, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29026864/gastroparesis-as-the-sole-presenting-feature-of-neuromyelitis-optica
#4
Ahmed Salahudeen, Tejal Mistry
A 33-year-old African-American woman recently diagnosed with severe idiopathic gastroparesis was readmitted for hypoxic respiratory failure secondary to aspiration pneumonia. A fiber-optic endoscopic evaluation of swallow study revealed severe pharyngeal dysphagia. Brain magnetic resonance imaging showed an ill-defined lesion in the posterior aspect of the medulla concerning for a demyelinating process. Serum neuromyelitis optica immunoglobulin G returned positive. Neuromyelitis optica treatment resulted in the patient's clinical improvement...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29025172/-anti-myelin-oligodendrocyte-glycoprotein-antibodies-in-paediatric-patients-with-optic-neuritis
#5
Helmut Tegetmeyer, Andreas Merkenschlager
Background Myelin oligodendrocyte glycoprotein (MOG) is located on the surface of oligodendrocytes and myelin in the central nervous system. MOG-IgG is associated with acute disseminated encephalomyelitis (ADEM), relapsing and bilateral optic neuritis (NNO), and transverse myelitis (TM) in both paediatric and adult patients. The combination of NNO and TM or other inflammatory brain lesions is a typical feature of neuromyelitis optica spectrum disorders (NMO-SD) which are associated with specific pathogenic autoantibodies against the water channel aquaporin-4 (AQP4-IgG)...
October 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29021839/diffusion-tensor-imaging-for-multilevel-assessment-of-the-visual-pathway-possibilities-for-personalized-outcome-prediction-in-autoimmune-disorders-of-the-central-nervous-system
#6
REVIEW
Joseph Kuchling, Alexander U Brandt, Friedemann Paul, Michael Scheel
The afferent visual pathway represents the most frequently affected white matter pathway in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). Diffusion tensor imaging (DTI) can reveal microstructural or non-overt brain tissue damage and quantify pathological processes. DTI facilitates the reconstruction of major white matter fiber tracts allowing for the assessment of structure-function and damage-dysfunction relationships. In this review, we outline DTI studies investigating the afferent visual pathway in idiopathic optic neuritis (ON), NMOSD, and MS...
September 2017: EPMA Journal
https://www.readbyqxmd.com/read/28991690/neuromyelitis-optica-spectrum-disorders-with-antibodies-to-myelin-oligodendrocyte-glycoprotein-or-aquaporin-4-clinical-and-paraclinical-characteristics-in-algerian-patients
#7
Melissa Bouzar, Smail Daoudi, Samira Hattab, Amel A Bouzar, Kumaran Deiva, Brigitte Wildemann, Markus Reindl, Sven Jarius
BACKGROUND: Neuromyelitis optica (NMO) is a severe autoimmune inflammatory disorder of the central nervous system. NMO and its abortive forms are referred to as NMO spectrum disorders (NMOSD). NMOSD are mostly associated with antibodies to aquaporin-4 (AQP4-IgG). However, recent studies have demonstrated antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) in a subset of patients. Data on NMOSD in North Africa are sparse. OBJECTIVE: To describe the frequency of MOG-IgG and AQP4-IgG among patients with optic neuritis (ON) and/or myelitis in Algeria as well as the clinical and paraclinical features associated with these antibodies...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28990252/differential-brainstem-atrophy-patterns-in-multiple-sclerosis-and-neuromyelitis-optica-spectrum-disorders
#8
Chi-Yan Lee, Henry Ka-Fung Mak, Pui-Wai Chiu, Hing-Chiu Chang, Frederik Barkhof, Koon-Ho Chan
BACKGROUND: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are central nervous system (CNS) inflammatory demyelinating disorders. It is clinically important to distinguish MS from NMOSD, as treatment and prognosis differ. Brainstem involvement is common in both disorders. PURPOSE: To investigate whether the patterns of brainstem atrophy on volumetric analysis in MS and NMOSD were different and correlated with clinical disability. STUDY TYPE: Case-control cross-sectional study...
October 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28988734/intractable-nausea-due-to-the-area-postrema-syndrome-of-neuromyelitis-optica-an-uncommon-cause-of-a-common-symptom
#9
Allison Snyder, Angela D Smedley, Stephen G Reich
BACKGROUND: Nausea and vomiting are common emergency department (ED) complaints. Neuromyelitis optica, a demyelinating disorder, has a predilection for the area postrema, the central nausea and vomiting center. Demyelinating lesions in this region cause intractable nausea and vomiting. CASE REPORT: We present a case of area postrema syndrome due to neuromyelitis optica in a 34-year-old woman who was seen in several EDs before the appropriate diagnosis was made. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Nausea and vomiting are complaints that commonly bring people to the ED, thus, emergency physicians are likely to be the first to encounter and diagnose the area postrema syndrome...
October 5, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28987668/abnormal-brain-function-in-neuromyelitis-optica-a-fmri-investigation-of-mpasat
#10
Fei Wang, Yaou Liu, Jianjun Li, Matthew Sondag, Meng Law, Chi-Shing Zee, Huiqing Dong, Kuncheng Li
PURPOSE: Cognitive impairment with the Neuromyelitis Optica (NMO) patients is debated. The present study is to study patterns of brain activation in NMO patients during a pair of task-related fMRI. MATERIALS AND METHODS: We studied 20 patients with NMO and 20 control subjects matched for age, gender, education and handedness. All patients with NMO met the 2006 Wingerchuk diagnostic criteria. The fMRI paradigm included an auditory attention monitoring task and a modified version of the Paced Auditory Serial Addition Task (mPASAT)...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28987175/inflammatory-demyelinating-diseases-of-the-central-nervous-system
#11
Romana Höftberger, Hans Lassmann
Inflammatory demyelinating diseases are a heterogeneous group of disorders, which occur against the background of an acute or chronic inflammatory process. The pathologic hallmark of multiple sclerosis (MS) is the presence of focal demyelinated lesions with partial axonal preservation and reactive astrogliosis. Demyelinated plaques are present in the white as well as gray matter, such as the cerebral or cerebellar cortex and brainstem nuclei. Activity of the disease process is reflected by the presence of lesions with ongoing myelin destruction...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28986408/prevalence-and-clinical-features-of-neuromyelitis-optica-spectrum-disorders-in-northern-japan
#12
Hideki Houzen, Kimito Kondo, Masaaki Niino, Kazuhiro Horiuchi, Toshiyuki Takahashi, Ichiro Nakashima, Keiko Tanaka
OBJECTIVE: To clarify the prevalence and clinical characteristics of neuromyelitis optica spectrum disorders (NMOSD) in Japan and compare them with those in other ethnic populations. METHODS: Data processing sheets were sent to all related institutions in northern Japan and were collected from April to May 2016. Prevalence was determined on March 31, 2016, using the 2015 International Panel for NMO Diagnosis criteria. RESULTS: The crude prevalence was 4...
October 6, 2017: Neurology
https://www.readbyqxmd.com/read/28984163/epidemiology-of-nmosd-in-catalonia-influence-of-the-new-2015-criteria-in-incidence-and-prevalence-estimates
#13
Maria Sepúlveda, Marta Aldea, Domingo Escudero, Sara Llufriu, Georgina Arrambide, Susana Otero-Romero, J Sastre-Garriga, Lucía Romero-Pinel, Sergio Martínez-Yélamos, N Sola-Valls, Thais Armangué, Javier Sotoca, Antonio Escartín, René Robles-Cedeño, Lluís Ramió-Torrentà, Silvia Presas-Rodríguez, Cristina Ramo-Tello, Elvira Munteis, Raúl Pelayo, Laura Gubieras, Luis Brieva, Nicolau Ortiz, Mariona Hervás, Maria Alba Mañé-Martínez, Antonio Cano, Emili Vela, Mar Tintoré, Yolanda Blanco, Xavier Montalban, Francesc Graus, Albert Saiz
BACKGROUND: Population-based studies on neuromyelitis optica spectrum disorders (NMOSD) are limited, and it is unclear whether the rates have changed with the implementation of the new 2015 criteria. OBJECTIVES: To estimate the incidence and prevalence of NMOSD in Catalonia (Spain), using both the 2006 and the 2015 criteria. METHODS: In this clinic-based retrospective study, patients diagnosed with NMOSD between 2006 and 2015 were identified using multiple sources, including direct contact to all Catalan hospitals, identification of cases through the Catalan Health Surveillance System, and registry of antibodies to aquaporin-4 (AQP4-IgG) and myelin oligodendrocyte glycoprotein (MOG-IgG) in a reference laboratory...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28979797/epidemiology-of-neuromyelitis-optica-in-latin-america
#14
REVIEW
M P Alvarenga, Sergio Schimidt, Rm Papais Alvarenga
A major development over the past two decades was the recognition of recurrent neuromyelitis optica (NMO) as a particular central nervous system disorder different from multiple sclerosis (MS). Here we reviewed the epidemiology of NMO in Latin America (LATAM). A predominance of a mixed population is found in this region. Recurrent NMO in black women was described in the Caribbean Islands and in Rio de Janeiro. The prevalence of NMO in LATAM varied from 0.37/100,000 (Volta Redonda city) to 4.2/100,000 inhabitants (Caribbean Islands)...
July 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28970675/role-of-low-plasma-volume-treatment-on-clinical-efficacy-of-plasmapheresis-in-neuromyelitis-optica
#15
Akshay Batra, Sundar Periyavan
BACKGROUND: Neuromyelitis optica (NMO) is an autoimmune demyelinating disease preferentially targeting the optic nerves and spinal cord. Plasmapheresis (PP) is an effective adjunct therapy in severe NMO attacks. The recommended minimum plasma volume to be treated per session of PP is equivalent to total plasma volume (TPV) of the patient. AIM: To study the effect of lower plasma volume treated in patients with NMO on clinical efficacy of plasmapheresis in comparison to minimum recommended volume...
July 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28968830/antibodies-to-aquaporins-are-frequent-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#16
John S Tzartos, Christos Stergiou, Dimitrios Daoussis, Paraskevi Zisimopoulou, Andrew P Andonopoulos, Vassiliki Zolota, Socrates J Tzartos
Objectives: Several aquaporins (AQPs) are present in the salivary glands, likely contributing to their secretions. AQP dysfunction may contribute to the salivary gland dysfunction in SS. Antibodies to AQP4 and AQP1 are detected in neuromyelitis optica and are believed to play a pathogenic role. We aimed to search for antibodies to several AQPs in the sera from SS patients in an effort to shed light on the pathogenic mechanisms of SS. Methods: We searched for antibodies to six AQPs in the sera of 34 SS patients without neurological findings using ELISAs with synthetic peptides corresponding to the three extracellular domains of each AQP, radioimmunoassays with AQPs, Western blots and competition experiments with cell-embedded AQPs...
August 31, 2017: Rheumatology
https://www.readbyqxmd.com/read/28967297/predictors-of-outcome-in-a-large-retrospective-cohort-of-patients-with-transverse-myelitis
#17
Matteo Gastaldi, Enrico Marchioni, Paola Banfi, Valeria Mariani, Laura Di Lodovico, Roberto Bergamaschi, Enrico Alfonsi, Paola Borrelli, Ottavia Eleonora Ferraro, Elisabetta Zardini, Anna Pichiecchio, Andrea Cortese, Patrick Waters, Mark Woodhall, Mauro Ceroni, Marco Mauri, Diego Franciotta
BACKGROUND: Transverse myelitis (TM) is an inflammatory disorder that can be idiopathic or associated with central nervous system autoimmune/dysimmune inflammatory diseases, connective tissue autoimmune diseases, or post-infectious neurological syndromes. Prognosis of initial TM presentations is uncertain. OBJECTIVE: To identify outcome predictors in TM. METHODS: Retrospective study on isolated TM at onset. Scores ⩾3 on the modified Rankin scale (mRS) marked high disability...
September 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28964319/corrigendum-to-anti-c1q-autoantibodies-in-patients-with-neuromyelitis-optica-spectrum-disorders-j-neuroimmunol-310-2017-150-157
#18
Nobuaki Yoshikura, Akio Kimura, Yuichi Hayashi, Takashi Inuzuka
No abstract text is available yet for this article.
November 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28955716/muscle-damage-in-patients-with-neuromyelitis-optica-spectrum-disorder
#19
Hong-Xi Chen, Qin Zhang, Zhi-Yun Lian, Ju Liu, Zi-Yan Shi, Xiao-Hui Miao, Hui-Ru Feng, Qin Du, Jing-Lu Xie, Shao-Li Yao, Hong-Yu Zhou
OBJECTIVE: Increasing evidence has shown that skeletal muscle damage plays a role in neuromyelitis optica spectrum disorder (NMOSD). The objective of this study was to compare the serum creatine kinase (sCK) levels in NMOSD patients with different clinical statuses. METHODS: In the observational study, levels of sCK were measured during the acute and stable phases for patients with NMOSD and healthy controls (HCs). RESULTS: We enrolled 168 patients with NMOSD (female:male ratio, 153:15; age: 43...
November 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28955334/the-role-of-brain-reactive-autoantibodies-in-brain-pathology-and-cognitive-impairment
#20
REVIEW
Simone Mader, Lior Brimberg, Betty Diamond
Antibodies to different brain proteins have been recently found to be associated with an increasing number of different autoimmune diseases. They need to penetrate the blood-brain barrier (BBB) in order to bind antigens within the central nervous system (CNS). They can target either neuronal or non-neuronal antigen and result in damage either by themselves or in synergy with other inflammatory mediators. Antibodies can lead to acute brain pathology, which may be reversible; alternatively, they may trigger irreversible damage that persists even though the antibodies are no longer present...
2017: Frontiers in Immunology
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