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https://www.readbyqxmd.com/read/29774231/semaphorin3a-signaling-is-dispensable-for-motor-axon-reinnervation-of-the-adult-neuromuscular-junction
#1
Jennifer L Shadrach, Brian A Pierchala
The neuromuscular junction (NMJ) is a specialized synapse that is formed by motor axon innervation of skeletal muscle fibers. The maintenance of motor-muscle connectivity is critical for the preservation of muscle tone and generation of movement. Injury can induce a robust regenerative response in motor axons, but severe trauma or chronic denervation resulting from neurodegenerative disease typically leads to inefficient repair and poor functional recovery. The axon guidance molecule Semaphorin3A (Sema3A) has been implicated as a negative regulator of motor innervation...
May 2018: ENeuro
https://www.readbyqxmd.com/read/29773764/degloving-lower-leg-injury-the-importance-of-additional-treatment-negative-pressure-and-hyperbaric-oxygen-therapy
#2
Piotr Stabryła, Joanna Kulińska, Łukasz Warchoł, Anna Kasielska-Trojan, Wojciech Gaszyński, Bogusław Antoszewski
Degloving injury poses a severe therapeutic challenge concerning both trauma and plastic surgery. The injury involves separation of skin and subcutaneous tissue from fascia and muscles. Treatment is often long-lasting and brings unsatisfying results due to the extent of damage, risk of infection and massive blood loss. In this article, we present the management and therapeutic outcomes of a patient admitted due to the degloving injury of the lower extremity caused by workplace accident. We described the complexity of treatment including surgical intervention as well as additional treatment, which combined brought good esthetic outcome...
April 30, 2018: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29773455/inferior-vena-cava-filter-strut-penetration-into-the-vertebral-column-a-case-of-10-year-clinical-follow-up
#3
David A Petrov, Aakash Chauhan, Sean Fitzpatrick, Daniel T Altman, Bethany Casagranda
BACKGROUND: The rate of vena cava (IVC) filter placement has increased over the past decade, especially in the orthopaedic trauma patient population. With the increasing use of IVC filters, radiologists and referring clinicians must be familiar with potential complications. CLINICAL CASE: This case report presents an 18-year-old polytraumatized patient who had an IVC filter placed and required T8-L2 posterior spinal fusion. At 4.5 years of follow-up, a computed tomography (CT) scan for painful spinal hardware incidentally found that the IVC filter had migrated into the L3 vertebral body...
April 18, 2018: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29771827/the-influence-of-socioeconomic-factors-on-the-epidemiology-of-maxillofacial-fractures-in-southern-italy
#4
Carolina Sbordone, Ida Barca, Marzia Petrocelli, Giovanni Dell'Aversana Orabona, Luigi Angelo Vaira, Walter Colangeli, Maria Giulia Cristofaro, Mario Giudice, Amerigo Giudice, Francesco Maria Cassandro, Federica Attanasi, Giorgio Iaconetta, Luigi Califano
Maxillofacial fractures represent a serious public health problem. Their epidemiology is extremely variable and its analysis is crucial to establish effective treatment and prevention of these injuries. The aim of this multicentric retrospective study was to analyze causes, demographics, incidence, characteristics of 987 patients diagnosed with maxillofacial trauma between 2011 and 2015 at Complex Operative Unit of Maxillofacial Surgery of Federico II University of Naples and Magna Graecia University of Catanzaro, Italy; 657 male and 310 female patients were admitted in the study...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29770222/recurrent-vertebral-fractures-in-a-young-adult-a-closer-look-at-bone-health-in-type-1-diabetes-mellitus
#5
Eleanor P Thong, Sarah Catford, Julie Fletcher, Phillip Wong, Peter J Fuller, Helena Teede, Frances Milat
The association between type 1 diabetes mellitus (T1DM) and bone health has garnered interest over the years. Fracture risk is known to be increased in individuals with T1DM, although bone health assessment is not often performed in the clinical setting. We describe the case of a 21-year-old male with longstanding T1DM with multilevel vertebral fractures on imaging, after presenting with acute back pain without apparent trauma. Dual-energy X-ray absorptiometry (DXA) revealed significantly reduced bone mineral density at the lumbar spine and femoral neck...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29769591/clinical-retrospective-case-control-study-on-the-mechanics-of-obstacle-in-mouth-opening-and-malocclusion-in-patients-with-maxillofacial-fractures
#6
Hai-Hua Zhou, Kun Lv, Rong-Tao Yang, Zhi Li, Xue-Wen Yang, Zu-Bing Li
This study aims to identify and distinguish various factors that may influence the clinical symptoms (limited mouth opening and malocclusion) in patients with maxillofacial fractures. From January 2000 to December 2009, 963 patients with maxillofacial fractures were enrolled in this statistical study to aid in evaluating the association between various risk factors and clinical symptoms. Patients with fractured posterior mandibles tended to experience serious limitation in mouth opening. Patients who sustained coronoid fractures have the highest risk of serious limitation in mouth opening (OR = 9...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769368/the-reconstructive-trauma-surgery-interface-fellowship-and-its-applicability-to-military-and-civilian-trainees
#7
EDITORIAL
Douglas Hammond, J Breeze, D Evriviades
The Reconstructive Trauma Surgery Fellowship is a based at the Queen Elizabeth Hospital, Birmingham, and focuses on the multidisciplinary management of major trauma from presentation to discharge. It is unique to the UK in that it provides both management and leadership experience as well as operative surgical skills particularly in terms of reconstruction on complex trauma patients including those from the military. This paper describes the relevance of fellowships in modern surgical training, composition of the reconstructive trauma fellowship and the relevance for both civilian and military trainees...
May 16, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29769005/adenosine-synthetic-methods-of-its-derivatives-and-antitumor-activity
#8
Margarita Gutierrez, Francisco Valdes, Victor Luna, Barbara Arevalo, Nelson Brown
Since 1929, several researchers have conducted studies in relation the nucleoside of adenosine (1) mainly distribution identifying, characterizing their biological importance and synthetic chemistry to which this type of molecule has been subjected to obtain multiple of its derivatives. The receptors that interact with adenosine and its derivatives, called purinergic receptors, are classified as A1, A2A, A2B and A3. In the presence of agonists and antagonists, these receptors are involved in various physiological processes and diseases...
May 16, 2018: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29763389/how-should-complex-communication-responsibilities-be-distributed-in-surgical-education-settings
#9
Bradley M Dennis, Allan B Peetz
Part of any trauma surgeon's job is communicating effectively in difficult, often time-limited, situations. The ability to effectively discuss topics like goals of care in these settings has a direct effect on patient care. Many factors contribute to the complexity of these conversations, including patient, physician, surrogate, and system-specific factors. In responding to the case of Mr. D and Dr. J, we attempt to outline and analyze some of the moral challenges and ethical questions that this professional responsibility poses to trauma surgeons and trainees...
May 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29761995/-the-progress-of-research-on-three-dimensional-printed-jaw-scaffolds
#10
REVIEW
Shuaishuai Cao, Miao Zhou
Large defects of jaw caused by tumor, trauma and so on in oral and maxillofacial region lead to facial deformity, language and chewing dysfunction, which severely damage the patient's life quality. Three-dimensional printing (3DP) is also named additive manufacturing (AM), which can print materials layer by layer to create three-dimensional objects. The complex shape of jaw defects can be accurately reconstructed using 3DP scaffold combined with image data, computer-aided-design and manufacture. It has specific advantages compared with traditional way of jaw reconstruction and has attracted much attention in the field of jaw tissue engineering recently...
December 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29760552/patients-receiving-chiropractic-care-in-a-neurorehabilitation-hospital-a-descriptive-study
#11
Robert D Vining, Stacie A Salsbury, W Carl Cooley, Donna Gosselin, Lance Corber, Christine M Goertz
Objectives: Individuals rehabilitating from complex neurological injury require a multidisciplinary approach, which typically does not include chiropractic care. This study describes inpatients receiving multidisciplinary rehabilitation including chiropractic care for brain injury, spinal cord injury (SCI), stroke, and other complex neurological conditions. Design: Chiropractic services were integrated into Crotched Mountain Specialty Hospital (CMSH) through this project...
2018: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/29758989/the-double-hazard-of-bleeding-and-thrombosis-in-hemostasis-from-a-clinical-point-of-view-a-global-assessment-by-rotational-thromboelastometry-rotem
#12
Olga Meltem Akay
Hemostasis is a complex dynamic process involving bleeding and thrombosis as two end-points. Conventional coagulation tests which are measured in plasma examine only isolated portions of the coagulation cascade, thereby giving no information on important interactions essential to the clinical evaluation of hemostatic function. Thromboelastography (TEG), originally described in 1948 has improved over the decades and become a valuable tool of coagulation testing because of the limitations of standard coagulation tests...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29758581/-managment-of-acute-low-back-pain-without-trauma-an-algorithm
#13
Carolin Melcher, Bernd Wegener, Volkmar Jansson, Wolf Mutschler, Karl-Georg Kanz, Christof Birkenmaier
BACKGROUND: Low back pain is a common problem for primary care providers, outpatient clinics and A&E departments. The predominant symptoms are those of so-called "unspecific back pain", but serious pathologies can be concealed by the clinical signs. Especially less experienced colleagues have problems in treating these patients, as - despite the multitude of recommendations and guidelines - there is no generally accepted algorithm. METHODS: After a literature search (Medline/Cochrane), 158 articles were selected from 15,000 papers and classified according to their level of evidence...
May 14, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29756600/the-development-of-neural-stimulators-a-review-of-preclinical-safety-and-efficacy-studies
#14
Robert K Shepherd, Joel Villalobos, Owen Burns, David Nayagam
OBJECTIVE: Given the rapid expansion of the field of neural stimulation and the rigorous regulatory approval requirements required before these devices can be applied clinically, it is important that there is clarity around conducting preclinical safety and efficacy studies required for the development of this technology. APPROACH: The present review examines basic design principles associated with the development of a safe neural stimulator and describes the suite of preclinical safety studies that need to be considered when taking a device to clinical trial...
May 14, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29755850/three-dimensional-printing-and-cell-therapy-for-wound-repair
#15
REVIEW
Sylvia van Kogelenberg, Zhilian Yue, Jeremy N Dinoro, Christopher S Baker, Gordon G Wallace
Significance: Skin tissue damage is a major challenge and a burden on healthcare systems, from burns and other trauma to diabetes and vascular disease. Although the biological complexities are relatively well understood, appropriate repair mechanisms are scarce. Three-dimensional bioprinting is a layer-based approach to regenerative medicine, whereby cells and cell-based materials can be dispensed in fine spatial arrangements to mimic native tissue. Recent Advances: Various bioprinting techniques have been employed in wound repair-based skin tissue engineering, from laser-induced forward transfer to extrusion-based methods, and with the investigation of the benefits and shortcomings of each, with emphasis on biological compatibility and cell proliferation, migration, and vitality...
May 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29754158/-a-phd-completed-midfacial-trauma-patients-in-amsterdam-an-epidemiological-survey
#16
E G Salentijn
A population of patients in Amsterdam with midfacial fractures was studied. Traffic accidents were found to be the most common cause, followed by violence and falls. The zygomatic complex was the most common fracture site. The majority of surgically treated patients consisted of men between 20 and 29 years of age. In addition to fracture displacement, indicative factors for surgery appear to be age, comorbidity and the presence or absence of functional problems. 8.1% of the surgically treated patients appear to have suffered brain damage...
May 2018: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/29753275/cervical-spine-fracture-through-a-cervical-disc-replacement
#17
M Flanagan, D T Cawley, N Cassidy
INTRODUCTION: We report a rare case of cervical spine trauma through a cervical disc replacement and adjacent multilevel disc fusions. Cervical disc replacement (CDR) is a viable option for the surgical treatment of degenerative disc disease however long term follow up data regarding this operative technique is poor specifically relating to traumatic complications. We know of no previous reports of bilateral cervical pedicle fractures occurring adjacent to CDR and anterior cervical spine instrumentation...
March 29, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29745761/diagnostic-reliability-of-low-dose-multidetector-computed-tomography-and-cone-beam-computed-tomography-in-maxillofacial-trauma-an-experimental-blinded-and-randomized-study
#18
Romke Rozema, Michiel Hj Doff, Peter Ma van Ooijen, Douwe Postmus, Henriëtte E Westerlaan, Martijn F Boomsma, Baucke van Minnen
OBJECTIVE: To assess the diagnostic reliability of low dose Multidetector Computed Tomography (MDCT) and Cone Beam Computed Tomography (CBCT) for zygomaticomaxillary fracture diagnosis. METHODS: Unilateral zygomaticomaxillary fractures were inflicted on four out of six fresh frozen human cadaver head specimens. All specimens were scanned using four MDCT and two CBCT imaging protocols of which the radiation exposure was systematically reduced. A blinded diagnostic routine was simulated at which 16 radiologists and 8 oral and maxillofacial (OMF) surgeons performed randomized image assessments...
May 10, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29744730/persistent-auditory-nerve-damage-following-kainic-acid-excitotoxicity-in-the-budgerigar-melopsittacus-undulatus
#19
Kenneth S Henry, Kristina S Abrams
Permanent loss of auditory nerve (AN) fibers occurs with increasing age and sound overexposure, sometimes without hair cell damage or associated audiometric threshold elevation. Rodent studies suggest effects of AN damage on central processing and behavior, but these species have limited capacity to discriminate low-frequency speech-like sounds. Here, we introduce a new animal model of AN damage in an avian communication specialist, the budgerigar (Melopsittacus undulatus). The budgerigar is a vocal learner and speech mimic with sensitive low-frequency hearing and human-like behavioral sensitivity to many complex signals including speech components...
May 9, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29742940/the-role-of-oxidative-stress-in-anxiety-disorder-cause-or-consequence
#20
Alessandra das Graças Fedoce, Frederico Ferreira, Robert G Bota, Vicent Bonet-Costa, Patrick Y Sun, Kelvin J A Davies
Anxiety disorders are the most common mental illness in the USA affecting 18% of the population. The cause(s) of anxiety disorders is/are not completely clear, and research in the neurobiology of anxiety at the molecular level is still rather limited. Although mounting clinical and preclinical evidence now indicates that oxidative stress may be a major component of anxiety pathology, whether oxidative stress is the cause or consequence remains elusive. Studies conducted over the past few years suggest that anxiety disorders may be characterized by lowered antioxidant defenses and increased oxidative damage to proteins, lipids and nucleic acids...
May 9, 2018: Free Radical Research
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