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Marzieh Khoshbin Nazdik, Mohammad Taheri, Mir Davood Omrani, Elham Sajjadi, Shahram Arsang-Jang, Zeinab Kazaei Koohpar, Hidetoshi Inoko, Arezou Sayad
OBJECTIVES: Multiple sclerosis (MS) is an autoimmune disease involving the central nervous system (CNS) with unknown immunopathogenic mechanisms. Matrix metalloproteinase-9 (MMP-9) facilitates T-cell migration into the CNS while the tissue inhibitor matrix metalloproteinase-1 (TIMP-1) inhibits MMP-9 actions. The aim of this study was to evaluate the expression of TIMP-1 RNA and MMP-9/TIMP-1 RNA ratio in blood cells of Iranian patients with relapsing-remitting multiple sclerosis (RRMS) treated with IFNb...
September 22, 2016: Human Antibodies
P S Cho, S B Bauer, M Pennison, I Rosoklija, A L Bellows, T Logvinenko, S Khoshbin, J G Borer
BACKGROUND: Sacral agenesis (SA) is a rare congenital condition that refers to the absence of part or all of two or more lower sacral vertebral bodies. It can be associated with neurogenic bladder dysfunction that does not necessarily correlate with the level of spinal or skeletal defect. Patients with SA should undergo urodynamic studies (UDS) to guide lower urinary tract (LUT) management. OBJECTIVE: This review aimed to update the present institutional experience since 1981 of this rare patient population with detailed, long-term follow-up of bladder and kidney function...
June 2016: Journal of Pediatric Urology
Amir Khoshbin, Ujash Sheth, Darrell Ogilvie-Harris, Nizar Mahomed, Richard Jenkinson, Rajiv Gandhi, David Wasserstein
PURPOSE: The aim of this study was to identify the survivorship of high tibial osteotomy (HTO) to total knee arthroplasty (TKA) on a population level, and identify the patient, provider and surgical factors that influenced eventual TKA. METHODS: Administrative records from physician billings and hospital admissions were used to identify all adults in Ontario, Canada, who underwent an HTO from 1994 to 2010. The primary outcome was time to TKA, which was estimated using Kaplan-Meier (KM) survival analysis...
November 4, 2015: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Timothy Leroux, Darrell Ogilvie-Harris, Christian Veillette, Jaskarndip Chahal, Tim Dwyer, Amir Khoshbin, Patrick Henry, Nizar Mahomed, David Wasserstein
BACKGROUND: Clinical studies of shoulder dislocations typically include adult patients (>16 years of age). Only small case series of patients aged 10 to 16 years are available to guide management. PURPOSE: Using a cohort of patients aged 10 to 16 years, this study sought to determine (1) the incidence density rate (IDR) of primary anterior shoulder dislocations requiring closed reduction (CR) and (2) the rate of and risk factors for repeat shoulder CR. STUDY DESIGN: Cohort study (prognosis); Level of evidence, 2...
September 2015: American Journal of Sports Medicine
Ali Reza Khoshbin, Fahimeh Mohamadabadi, Fatemeh Vafaeian, Adel Babania, Saeideh Akbarian, Reza Khandozi, Mohamad Ali Sadrebazaz, Ehsan Hatami, Hamid Reza Joshaghani
BACKGROUND: Gamma radiation effects on the erythrocyte membrane from three different functional parts, lipid bilayer, cytoskeleton and protein components. When the red cell membrane is exposed to radiation, it loses its integrity and hemoglobin leaks out. In addition, irradiation leads to lipid peroxidation and the products of this process, leading to hemolysis. The aim of the present study was to measure osmotic fragility (OF) of red blood cells and malondialdehyde (MDA) levels as a marker of oxidative injury in breast cancer patients treated with radiation and chemotherapy...
July 2015: Reports of Practical Oncology and Radiotherapy
Timothy Leroux, Amir Khoshbin, Markku T Nousiainen
OBJECTIVES: To compare the effect fluoroscopy or electromagnetic (EM) guidance has on the learning of locking screw insertion in tibial nails in surgical novices. METHODS: A randomized, prospective, controlled trial was conducted involving 18 surgical trainees with no prior experience inserting locking screws in intramedullary nails. After a training session using fluoroscopy, participants underwent a pretest using fluoroscopic guidance. Participants were then randomized into either the fluoroscopy or EM group and were further trained using their respective technique...
October 2015: Journal of Orthopaedic Trauma
Amir Khoshbin, Magdalena Lysenko, Peggy Law, James G Wright
BACKGROUND: Removal of instrumentation is often recommended as part of treatment for spinal infections, but studies have reported eradication of infection even with instrumentation retention by using serial débridements and adjuvant antibiotic pharmacotherapy. We sought to determine the effect of instrumentation retention or removal on outcomes in children with spinal infections. METHODS: We retrospectively reviewed the cases of patients who experienced early (< 3 mo) or late (≥ 3 mo) infected spinal fusions...
April 2015: Canadian Journal of Surgery. Journal Canadien de Chirurgie
Amir Khoshbin, Magdalena Lysenko, Peggy Law, James G Wright
BACKGROUND: Removal of instrumentation is often recommended as part of treatment for spinal infections, but studies have reported eradication of infection even with instrumentation retention by using serial débridements and adjuvant antibiotic pharmacotherapy. We sought to determine the effect of instrumentation retention or removal on outcomes in children with spinal infections. METHODS: We retrospectively reviewed the cases of patients who experienced early (< 3 mo) or late (≥ 3 mo) infected spinal fusions...
February 1, 2015: Canadian Journal of Surgery. Journal Canadien de Chirurgie
Arman Taheri, Shahram Firouzi-Marani, Masoud Khoshbin
Eagle syndrome is a rare condition caused by elongation of the styloid process or calcification of the stylohyoid ligament. Patients with Eagle syndrome typically present with dysphagia, dysphonia, cough, voice changes, otalgia, sore throat, facial pain, foreign body sensation, headache, vertigo, and neck pain. Here we report a case in which the patient initially presented with sore throat, left-sided facial pain, and cough. This case report provides a brief review of the diagnosis and nonsurgical management of this rare syndrome...
October 2014: Journal of the Korean Association of Oral and Maxillofacial Surgeons
Shahnaz Ghafoori, Abbasali Keshtkar, Patricia Khashayar, Mehdi Ebrahimi, Majid Ramezani, Zahra Mohammadi, Farzane Saeidifard, Nasrin Nemati, Maryam Khoshbin, Solmaz Azizian, Fatemeh Zare, Sara Shirazi, Bagher Larijani
BACKGROUND: The present study is designed to assess the incidence rate of osteoporotic fracture and its risk factors, particularly those used to predict the 10-year risk of osteoporotic fracture in FRAX based on the data gathered through a follow up cohort initiated in 2000. METHODS: The present retrospective cohort was conducted on men and women from 40 to 90 years of age enrolled in the IROSTEOPs study. A phone survey was conducted during 2013 and beginning of 2014 to assess the fractures (traumatic/osteoporotic) occurring at the time of inclusion until the date of the telephone survey, its type and mechanism, and the patient's age at the time of accident...
2014: Journal of Diabetes and Metabolic Disorders
Amir Khoshbin, Liora Caspi, Peggy W Law, Sandra Donaldson, Derek Stephens, Trevor da Silva, Catharine S Bradley, James G Wright
STUDY DESIGN: Retrospective comparative study. OBJECTIVE: To evaluate the outcome of bracing in patients with juvenile idiopathic scoliosis (JIS) at either skeletal maturity or time of scoliosis surgery. SUMMARY OF BACKGROUND DATA: JIS is generally thought to have poor outcomes with high rates of surgical fusion. METHODS: All patients with JIS between the ages of 4 and 10 years treated with a brace at the Hospital for Sick Children (SickKids) between 1989 and 2011 were eligible...
January 1, 2015: Spine
Amir Khoshbin, Jeannette P So, Ilyas S Aleem, Derek Stephens, Anne G Matlow, James G Wright
OBJECTIVE: To investigate the association between antibiotic prophylaxis (AP) and surgical-site infection in pediatric patients. BACKGROUND: Surgical-site infections (SSIs) are a major cause of postoperative morbidity and mortality. Despite numerous studies in adults, benefit of AP in preventing SSIs in children is uncertain. METHODS: Patients aged 0 to 21 years who underwent surgical procedures at a pediatric acute care hospital from April 1, 2009, to December 31, 2010, were assessed...
August 2015: Annals of Surgery
A Qyasian, Z Mohammadi, L Giardino, F Palazzi, S Shalavi, S Sabbaghi, E Khoshbin
The purpose of the present study was to determine the minimum inhibitory concentrations of Tetraclean, chlorhexidine, hydrogen peroxide, and sodium hypochlorite against Candida albicans.Amphotericin B was used as positive control and RPMI plus 1 ml Candida suspension was used as negative control. Serial dilution method was used to determine MIC of the irrigants. Findings showed that all positive controls demonstrated complete inhibition of C. albicans at concentration of 0.78 microg mL(-1). On the other hand, all negative controls were positive for fungal growth which confirms the methodology of the study...
July 2014: Nigerian Journal of Medicine: Journal of the National Association of Resident Doctors of Nigeria
A Khoshbin, L Vivas, P W Law, D Stephens, A M Davis, A Howard, J G Jarvis, J G Wright
The purpose of this study was to evaluate the long-term outcome of adults with spina bifida cystica (SBC) who had been treated either operatively or non-operatively for scoliosis during childhood. We reviewed 45 patients with a SBC scoliosis (Cobb angle ≥ 50º) who had been treated at one of two children's hospitals between 1991 and 2007. Of these, 34 (75.6%) had been treated operatively and 11 (24.4%) non-operatively. After a mean follow-up of 14.1 years (standard deviation (sd) 4.3) clinical, radiological and health-related quality of life (HRQOL) outcomes were evaluated using the Spina Bifida Spine Questionnaire (SBSQ) and the 36-Item Short Form Health Survey (SF-36)...
September 2014: Bone & Joint Journal
Joel T Katz, Shahram Khoshbin
Clinical educators use medical humanities as a means to improve patient care by training more self-aware, thoughtful, and collaborative physicians. We present three examples of integrating fine arts - a subset of medical humanities - into the preclinical and clinical training as models that can be adapted to other medical environments to address a wide variety of perceived deficiencies. This novel teaching method has promise to improve physician skills, but requires further validation.
2014: Transactions of the American Clinical and Climatological Association
Setareh Ghahari, Lana S Khoshbin, Susan J Forwell
BACKGROUND: The Multiple Sclerosis Self-Management Scale (MSSM) is currently the only measure that was developed specifically to address self-management among individuals with multiple sclerosis (MS). While good internal consistency (α = 0.85) and construct validity have been demonstrated, other psychometric properties have not been established. This study was undertaken to evaluate the criterion validity, test-retest reliability, and face validity of the MSSM. METHODS: Thirty-one individuals with MS who met the inclusion criteria were recruited to complete a series of questionnaires at two time points...
2014: International Journal of MS Care
Amir Khoshbin, Maryse Bouchard, David Wasserstein, Timothy Leroux, Peggy W Law, Hans J Kreder, Timothy R Daniels, James G Wright
Few studies have evaluated the incidence of subsequent operations after tarsal coalition resection. Using administrative databases, we followed up a cohort of patients who had undergone tarsal coalition resection to determine the rates and possible risk factors for subsequent resection or arthrodesis. Patients (aged 8 years or older) who had been treated from July 1994 to August 2009 in Canada were identified and included. Those with nonidiopathic coalitions were excluded. The time-to-event data for the earliest subsequent procedure were fit to a Cox proportional hazards model that evaluated the patient, operative, and provider factors...
May 2015: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Timothy Leroux, David Wasserstein, Patrick Henry, Amir Khoshbin, Tim Dwyer, Darrell Ogilvie-Harris, Nizar Mahomed, Christian Veillette
BACKGROUND: Reoperation rates following open reduction and internal fixation (ORIF) of midshaft clavicle fractures have been described, but reported rates of nonunion, malunion, infection, and implant removal have varied. We sought to establish baseline rates of, and risk factors for, reoperations following clavicle ORIF in a large population cohort. METHODS: Administrative databases were used to identify patients sixteen to sixty years of age who had undergone an ORIF of a closed, midshaft clavicle fracture from April 2002 to April 2010...
July 2, 2014: Journal of Bone and Joint Surgery. American Volume
Abdul Momen, Talat Afroze, Al-Muktafi Sadi, Amir Khoshbin, Hangjun Zhang, Jaehyun Choi, Steven Gu, Syed H Zaidi, Scott P Heximer, Mansoor Husain
CONTEXT: Regulator of G-protein signaling-2 (RGS2) inhibits Gq-mediated regulation of Ca(2+) signalling in vascular smooth muscle cells (VSMC). OBJECTIVE: RGS2 knockout (RGS2KO) mice are hypertensive and show arteriolar remodeling. VSMC proliferation modulates intracellular Ca(2+) concentration [Ca(2+)]i. RGS2 involvement in VSMC proliferation had not been examined. METHODS: Thymidine incorporation and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) conversion assays measured cell proliferation...
December 2014: Journal of Receptor and Signal Transduction Research
Joseph G Borer, Ruth Strakosha, Stuart B Bauer, David A Diamond, Melanie Pennison, Ilina Rosoklija, Shahram Khoshbin
PURPOSE: Concern in patients with bladder exstrophy after reconstruction regarding potential injury to pelvic neurourological anatomy and a resultant functional deficit prompted combined (simultaneous) cystometrography and electromyography after complete primary repair of bladder exstrophy. We determined whether complete primary repair of bladder exstrophy would adversely affect the innervation controlling bladder and external urethral sphincter function. MATERIALS AND METHODS: Complete primary repair of bladder exstrophy was performed via a modified Mitchell technique in newborns without osteotomy...
May 2014: Journal of Urology
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