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JOURNAL ARTICLE
Quinn V C van Hilst, Aston C Pearcy, Dan Preston, L James Wright, Christian G Hartinger, Heather J L Brooks, James D Crowley
A dynamic covalent approach was exploited to generate a family of homometallic [Pt n L2 n ]2 n + cage (predominantly [Pt2 L4 ]4+ systems) architectures. The family of platinum(II) architectures were characterized using 1 H nuclear magnetic resonance (NMR) and diffusion ordered spectroscopy (DOSY), electrospray ionization mass spectrometry (ESI-MS) and the molecular structures of two cages were determined by X-ray crystallography.
March 26, 2024: Chemical Communications: Chem Comm
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JOURNAL ARTICLE
Juul Achten, Duncan Appelbe, Louise Spoors, Nicholas Peckham, Rebecca Kandiyali, James Mason, David Ferguson, James Wright, Nicola Wilson, Jennifer Preston, Amy Moscrop, Matthew Costa, Daniel C Perry
AIMS: The management of fractures of the medial epicondyle is one of the greatest controversies in paediatric fracture care, with uncertainty concerning the need for surgery. The British Society of Children's Orthopaedic Surgery prioritized this as their most important research question in paediatric trauma. This is the protocol for a randomized controlled, multicentre, prospective superiority trial of operative fixation versus nonoperative treatment for displaced medial epicondyle fractures: the Surgery or Cast of the EpicoNdyle in Children's Elbows (SCIENCE) trial...
January 25, 2024: Bone & joint open
#3
JOURNAL ARTICLE
Yichen Fan, Andrew Sauer, Jonathan Kark, James Wright, Jung U Yoo
STUDY DESIGN: Retrospective database analysis. OBJECTIVE: Determine risk factors and failure rate of anterior odontoid screw fixation surgery. SUMMARY OF BACKGROUND DATA: Anterior odontoid screw fixation (AOSF) stabilizes type II dens fractures while preserving cervical motion. Despite having potential advantages, AOSF's failure rate and factors contributing to failure remain unknown. MATERIALS AND METHODS: We identified AOSF patients in the national claims database Pearldiver using CPT code 22318...
January 15, 2024: Clinical Spine Surgery
#4
JOURNAL ARTICLE
Gabrielle Audsley, Ambre Carpentier, Anne-Frédérique Pécharman, James Wright, Thomas M Roseveare, Ewan R Clark, Stuart A Macgregor, Ian M Riddlestone
[Ni(IMes)2 ] reacts with chloroboranes via oxidative addition to form rare unsupported Ni-boryls. In contrast, the oxidative addition of hydridoboranes is not observed and products from competing reaction pathways are identified. Computational studies relate these differences to the mechanism of oxidative addition: B-Cl activation proceeds via nucleophilic displacement of Cl- , while B-H activation would entail high energy concerted bond cleavage.
January 2, 2024: Chemical Communications: Chem Comm
#5
JOURNAL ARTICLE
Stefanie Croghan, Robert Malcolm, Hugh Flood, Stuart Mealing, Brooke Avey, Gavin Leonard, James Wright, Niall Davis, Michael Walsh
AIMS: Intraurethral catheter balloon inflation is a substantial contributor to significant catheter-related urethral injury. A novel safety valve has been designed to prevent these balloon-inflation injuries. The purpose of this evaluation was to assess the cost-effectiveness of urethral catheterisation with the safety valve added to a Foley catheter versus the current standard of care (Foley catheter alone). MATERIALS AND METHODS: The analysis was conducted from the UK public payer perspective on a hypothetical cohort of adults requiring transurethral catheterization...
December 21, 2023: Journal of Medical Economics
#6
JOURNAL ARTICLE
Hao Tan, Erin A Yamamoto, Spencer Smith, Jung Yoo, Jonathan Kark, Clifford Lin, Josiah Orina, Travis Philipp, Donald A Ross, Christina Wright, James Wright, Won Hyung A Ryu
INTRODUCTION: Interspinous process devices (IPDs) were developed as minimally invasive alternatives to open decompression surgery for spinal stenosis. However, given high treatment failure and reoperation rates, there has been minimal adoption by the spine surgeons. This study leveraged a national claims database to characterize national IPD usage patterns and postoperative outcomes following IPD implantation. METHOD: Using the PearlDiver database, we identified all patients who underwent 1- or 2-level IPD implantation between 2010 and 2018...
December 8, 2023: Pain Medicine
#7
JOURNAL ARTICLE
James Wright, Michelle Science, Selma Osman, Callum Arnold, Maya Sumaida, Natasha Crowcroft, Shelley L Deeks, Kevin Brown, Scott Halperin, Todd Hatchette, Elizabeth McLachlan, Aaron Campigotto, Susan Richardson, Shelly Bolotin
INTRODUCTION: Pertussis causes significant morbidity and mortality in infants aged <6 months. Maternal pertussis vaccination during pregnancy has been recommended in Canada since 2018 to reduce these negative outcomes. In the absence of routine immunization coverage data, our objective was to evaluate uptake in Toronto, Canada. METHODS: We recruited mother-infant pairs at The Hospital for Sick Children, Toronto, between 2018 and 2020. We performed logistic regression to examine associations between demographics and self-reported pertussis vaccination...
October 14, 2023: Vaccine
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JOURNAL ARTICLE
Adeline L Fecker, Maryam N Shahin, Samantha Sheffels, Joseph Girard Nugent, Daniel Munger, Parker Miller, Ryan Priest, Aclan Dogan, Wayne Clark, James Wright, Jesse L Liu
BACKGROUND: There is evidence that frailty is an independent predictor of worse outcomes after stroke. Similarly, although obesity is associated with a higher risk for stroke, there are multiple reports describing improved mortality and functional outcomes in higher body mass index (BMI) patients in a phenomenon known as the obesity paradox. We investigated the effect of low BMI on outcomes after mechanical thrombectomy (MT). METHODS: We conducted a retrospective analysis of 231 stroke patients who underwent MT at an academic medical center between 2020-2022...
October 5, 2023: Journal of Neurointerventional Surgery
#9
JOURNAL ARTICLE
Zahid Memon, Daniel Fridman, Sajid Soofi, Wardah Ahmed, Shah Muhammad, Arjumand Rizvi, Imran Ahmed, James Wright, Simon Cousens, Zulfiqar A Bhutta
BACKGROUND: Adopted in 2015, the sustainable development goals (SDGs) have set specific targets (SDG 3.2) for countries to reduce their neonatal mortality rate (NMR) to below 12 deaths per 1000 live births and under 5 mortality rate (U5MR) to below 25 deaths per 1000 live births by 2030. For Pakistan to achieve these targets, there is a need to measure these rates and understand the predictors of child mortality at sub-national level. Launched in 2016, the Umeed-e-Nau (UeN) or New Hope project is based on scaling up proven and effective Maternal and Newborn Child Health (MNCH) interventions in 8 of the highest burden districts of the country, using existing public sector platforms in Pakistan at both the community and facility level...
August 2023: Lancet Reg Health Southeast Asia
#10
JOURNAL ARTICLE
Aston C Pearcy, Lynn S Lisboa, Dan Preston, Nick B Page, Tristan Lawrence, L James Wright, Christian G Hartinger, James D Crowley
A new sequential metalation strategy that enables the assembly of a new more robust reduced symmetry heterobimetallic [PdPtL4 ]4+ cage C is reported. By exploiting a low-symmetry ditopic ligand (L) that features imidazole and pyridine donor units we were able to selectively form a [Pt(L)4 ]2+ "open-cage" complex. When this was treated with Pd(ii) ions the cage C assembled. 1 H and DOSY nuclear magnetic resonance (NMR) spectroscopy and electrospray ionisation mass spectrometry (ESIMS) data were consistent with the quantitative formation of the cage and the heterobimetallic structure was confirmed by single crystal X-ray crystallography...
August 16, 2023: Chemical Science
#11
JOURNAL ARTICLE
Tim Pfister, Tilo Söhnel, Terrence J Collins, L James Wright
The macrocyclic pro-ligand [H4L][OTf]2, which contains four carboxamide functions and two conjugated pyridinium groups, is easily deprotonated by the weak base sodium acetate to give the corresponding neutral pro-ligand [H2L]. Metalation of [H2L] with iron(II) chloride proceeds rapidly to form the macrocyclic complex, [FeIIICl(L)]. This is an effective catalyst for the oxidation of the organic dye orange II by hydrogen peroxide in aqueous solution and the kinetic parameters for this reaction have been determined...
August 2, 2023: Chemistry: a European Journal
#12
JOURNAL ARTICLE
Philip Bland, Harry Saville, Patty T Wai, Lucinda Curnow, Gareth Muirhead, Jadwiga Nieminuszczy, Nivedita Ravindran, Marie Beatrix John, Somaieh Hedayat, Holly E Barker, James Wright, Lu Yu, Ioanna Mavrommati, Abigail Read, Barrie Peck, Mark Allen, Patrycja Gazinska, Helen N Pemberton, Aditi Gulati, Sarah Nash, Farzana Noor, Naomi Guppy, Ioannis Roxanis, Guy Pratt, Ceri Oldreive, Tatjana Stankovic, Samantha Barlow, Helen Kalirai, Sarah E Coupland, Ronan Broderick, Samar Alsafadi, Alexandre Houy, Marc-Henri Stern, Stephen Pettit, Jyoti S Choudhary, Syed Haider, Wojciech Niedzwiedz, Christopher J Lord, Rachael Natrajan
SF3B1 hotspot mutations are associated with a poor prognosis in several tumor types and lead to global disruption of canonical splicing. Through synthetic lethal drug screens, we identify that SF3B1 mutant (SF3B1MUT ) cells are selectively sensitive to poly (ADP-ribose) polymerase inhibitors (PARPi), independent of hotspot mutation and tumor site. SF3B1MUT cells display a defective response to PARPi-induced replication stress that occurs via downregulation of the cyclin-dependent kinase 2 interacting protein (CINP), leading to increased replication fork origin firing and loss of phosphorylated CHK1 (pCHK1; S317) induction...
July 31, 2023: Nature Genetics
#13
JOURNAL ARTICLE
Laura Kelly, Judith Shore, James Wright, Craig Patrick, Hayden Holmes
OBJECTIVES: We aim to conduct an economic evaluation of the Optilume urethral drug-coated balloon (DCB) compared with endoscopic management for the treatment of recurrent anterior male urethral stricture in England. PATIENTS AND METHODS: A cohort Markov model was developed to estimate the costs and savings to the NHS over a 5-year time horizon of adopting Optilume for the treatment of anterior urethral male stricture versus current endoscopic standard of care. A scenario analysis was conducted which compared Optilume to urethroplasty...
July 2023: BJUI compass
#14
JOURNAL ARTICLE
Alyssa Indar, James Wright, Michelle Nelson
INTRODUCTION: Health care system transformations that align with the principles of integrated care require the collaborative efforts of various macro-, meso- and micro-level stakeholders. Understanding the roles of various system actors can improve collaboration in ways that support purposeful health system change. Professional associations (PAs) have considerable influence, but little is known about the strategies they use to influence health system transformation. METHODS: Using a qualitative descriptive approach, eight interviews with 11 senior level leaders from local PAs were conducted to learn about the strategies used to influence the province-wide reorganization of health care into Ontario Health Teams...
2023: International Journal of Integrated Care
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JOURNAL ARTICLE
Justin Lee, Nhu Tram Nguyen, James Wright, Ka-Kit David Yeung, Stephen Sagar, Do-Hoon Kim, Orest Ostapiak, Lilian Doerwald-Munoz, Timothy Whelan
BACKGROUND: Cancers of the head and neck region are often characterized by locally advanced, non-metastatic disease. Standard treatments for advanced cervico-facial cancers of the skin or primary head and neck squamous cell carcinoma (HNSCC) include combinations of surgery, radiation and chemotherapy, which are associated with high rates of acute toxicity and complications. Stereotactic body radiotherapy (SBRT) has been shown to be a promising modality of treatment for this patient population in retrospective studies; to our knowledge, there are no prospective clinical studies evaluating the safety and efficacy of SBRT in these patients...
April 26, 2023: BMC Cancer
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JOURNAL ARTICLE
Joel Rozowsky, Jiahao Gao, Beatrice Borsari, Yucheng T Yang, Timur Galeev, Gamze Gürsoy, Charles B Epstein, Kun Xiong, Jinrui Xu, Tianxiao Li, Jason Liu, Keyang Yu, Ana Berthel, Zhanlin Chen, Fabio Navarro, Maxwell S Sun, James Wright, Justin Chang, Christopher J F Cameron, Noam Shoresh, Elizabeth Gaskell, Jorg Drenkow, Jessika Adrian, Sergey Aganezov, François Aguet, Gabriela Balderrama-Gutierrez, Samridhi Banskota, Guillermo Barreto Corona, Sora Chee, Surya B Chhetri, Gabriel Conte Cortez Martins, Cassidy Danyko, Carrie A Davis, Daniel Farid, Nina P Farrell, Idan Gabdank, Yoel Gofin, David U Gorkin, Mengting Gu, Vivian Hecht, Benjamin C Hitz, Robbyn Issner, Yunzhe Jiang, Melanie Kirsche, Xiangmeng Kong, Bonita R Lam, Shantao Li, Bian Li, Xiqi Li, Khine Zin Lin, Ruibang Luo, Mark Mackiewicz, Ran Meng, Jill E Moore, Jonathan Mudge, Nicholas Nelson, Chad Nusbaum, Ioann Popov, Henry E Pratt, Yunjiang Qiu, Srividya Ramakrishnan, Joe Raymond, Leonidas Salichos, Alexandra Scavelli, Jacob M Schreiber, Fritz J Sedlazeck, Lei Hoon See, Rachel M Sherman, Xu Shi, Minyi Shi, Cricket Alicia Sloan, J Seth Strattan, Zhen Tan, Forrest Y Tanaka, Anna Vlasova, Jun Wang, Jonathan Werner, Brian Williams, Min Xu, Chengfei Yan, Lu Yu, Christopher Zaleski, Jing Zhang, Kristin Ardlie, J Michael Cherry, Eric M Mendenhall, William S Noble, Zhiping Weng, Morgan E Levine, Alexander Dobin, Barbara Wold, Ali Mortazavi, Bing Ren, Jesse Gillis, Richard M Myers, Michael P Snyder, Jyoti Choudhary, Aleksandar Milosavljevic, Michael C Schatz, Bradley E Bernstein, Roderic Guigó, Thomas R Gingeras, Mark Gerstein
Understanding how genetic variants impact molecular phenotypes is a key goal of functional genomics, currently hindered by reliance on a single haploid reference genome. Here, we present the EN-TEx resource of 1,635 open-access datasets from four donors (∼30 tissues × ∼15 assays). The datasets are mapped to matched, diploid genomes with long-read phasing and structural variants, instantiating a catalog of >1 million allele-specific loci. These loci exhibit coordinated activity along haplotypes and are less conserved than corresponding, non-allele-specific ones...
March 30, 2023: Cell
#17
RANDOMIZED CONTROLLED TRIAL
Mira Goldberg, Sameer Parpia, Eileen Rakovitch, Lynn Chang, Julie Bowen, Himanshu Lukka, Francisco Perera, Anthony Fyles, James Wright, Jonathan Sussman, Timothy Whelan
PURPOSE: The natural history of microinvasive (T1mi) breast cancer is uncertain. The objective was to evaluate long-term local and distant recurrence rates following breast conserving surgery (BCS) in a prospective cohort of patients with T1mi compared to T1a-2 disease who received whole breast irradiation (WBI) in the context of a randomized trial of hypofractionation. METHODS: 1234 patients with T1-2 N0 breast cancer were randomized to receive adjuvant WBI of 42...
April 2023: Breast: Official Journal of the European Society of Mastology
#18
JOURNAL ARTICLE
William D J Tremlett, Tilo Söhnel, James D Crowley, L James Wright, Christian G Hartinger
Using ferrocene-based ligand systems, a series of heterobimetallic architectures of the general formula [Pd m L n ] x + were designed with the aim of installing an opening and closing mechanism that would allow the release and binding of guest molecules. Palladium complex formation was achieved through coordination to pyridyl groups, and using 2-, 3-, and 4-pyridyl derivatives provided access to defined PdL, PdL2 , and Pd2 L4 structures, respectively. The supramolecular complexes were characterized using nuclear magnetic resonance (NMR) and infrared spectroscopy, mass spectrometry, and elemental analysis, and for some examples density functional theory calculations and single-crystal X-ray diffraction analysis...
February 27, 2023: Inorganic Chemistry
#19
JOURNAL ARTICLE
Spencer Smith, Rita Somogyi, James Wright, Clifford Lin, Jung Yoo
STUDY DESIGN: Retrospective review. OBJECTIVE: This study was undertaken to determine what constitutes "early optimal timing" of surgical management of central cord syndrome (CCS) with respect to a reduction of medical complications. SUMMARY OF BACKGROUND DATA: Data varies on the optimal time for surgical treatment of CCS with some studies favoring early intervention and others advocating that surgery can or should be delayed for 2-6 weeks...
June 1, 2023: Clinical Spine Surgery
#20
RANDOMIZED CONTROLLED TRIAL
Ranjan Sur, Gregory Pond, Conrad Falkson, Ming Pan, James Wright, Andrea Bezjak, Anne Dagnault, Edward Yu, Maha Almahmudi, Serge Puksa, Darin Gopaul, Theos Tsakiridis, Anand Swaminath, Peter Ellis, Timothy Whelan
PURPOSE: Uncontrolled studies suggest that the addition of high-dose-rate intraluminal brachytherapy (HDRIB) to external beam radiation therapy (EBRT) may improve palliation for patients with advanced non-small cell lung cancer (NSCLC). The purpose of this study was to evaluate the potential clinical benefit of adding HDRIB to EBRT in a multicenter randomized trial. METHODS AND MATERIALS: Patients with symptomatic stage III or IV NSCLC with endobronchial disease were randomized to EBRT (20 Gy in 5 daily fractions over 1 week or 30 Gy in 10 daily fractions over 2 weeks) or the same EBRT plus HDRIB (14 Gy in 2 fractions separated by 1 week)...
July 1, 2023: International Journal of Radiation Oncology, Biology, Physics
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