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"James Wright"

Alexander J Steiner, Nathalie Boulos, James Mirocha, Stephanie M Wright, Katherine L Collison, Waguih W IsHak
OBJECTIVES: Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) often have high comorbidity, consequently influencing patient-reported outcomes of depressive symptom severity, quality of life (QOL), and functioning. We hypothesized that the combined effects of concurrent PTSD and MDD would result in worse treatment outcomes, whereas individuals who achieved MDD remission would have better treatment outcomes. METHODS: We analyzed 2280 adult participants who received level 1 treatment (citalopram monotherapy) in the Sequenced Treatment Alternatives to Relieve Depression study, including 2158 participants with MDD without comorbid PTSD and 122 participants with MDD with comorbid PTSD (MDD + PTSD)...
October 18, 2016: Clinical Neuropharmacology
Magdalena Lysenko, Peggy Law, James Jarvis, James G Wright
PURPOSE: Healthcare providers have limited time to spend with scoliosis patients who are considering surgery and their families. The purpose of this study was to evaluate an e-health strategy to increase knowledge and coping in patients with scoliosis who are surgical candidates and their families. METHODS: We enrolled patients with scoliosis who were candidates for surgery and their families. Patients and their families completed the scoliosis knowledge questionnaire, meaning of illness questionnaire, social support and coping questionnaires before and after access to a comprehensive evidence-based scoliosis website ( http://www...
October 6, 2016: Journal of Children's Orthopaedics
Edmund C P Chedgy, James Douglas, Jonathan L Wright, Roland Seiler, Bas W G van Rhijn, Joost Boormans, Tilman Todenhöfer, Colin P Dinney, Colin C Collins, Michiel S Van der Heijden, Peter C Black
BACKGROUND: Bladder cancer is a leading cause of morbidity and mortality. Despite recent advances in understanding its molecular biology, the 5-year survival for muscle-invasive disease (muscle-invasive bladder cancer [MIBC]) remains approximately 50%. Although neoadjuvant chemotherapy (NAC) offers an established 5% absolute survival benefit at 5 years, only the 40% of patients with a major tumor response appear to benefit. There remains, therefore, a critical unmet need for predictive markers to determine which patients are best managed with NAC, as well as for novel targeted therapies to overcome resistance to NAC...
October 2016: Urologic Oncology
Christopher Richter, James Taylor, Joyanna Wright, Bradley Fletcher
BACKGROUND: Despite the emergence of several new oral anticoagulants, warfarin remains a widely used form of anticoagulation that continues to have a role in the treatment of cardiac and thrombotic conditions. OBJECTIVE: The goal of this study was to evaluate whether the R-T estimation, an equation developed in a previous study, was a valid clinical tool in managing patients' warfarin therapy in an anticoagulation clinic in lieu of obtaining a venipuncture international normalized ratio (INR) secondary to a high CoaguChek XS (CXS) INR...
August 2016: Annals of Pharmacotherapy
Dragoş-Adrian Roşca, Julio Fernandez-Cestau, James Morris, Joseph A Wright, Manfred Bochmann
The water-gas shift (WGS) reaction is an important process for the generation of hydrogen. Heterogeneous gold catalysts exhibit good WGS activity, but the nature of the active site, the oxidation state, and competing reaction mechanisms are very much matters of debate. Homogeneous gold WGS systems that could shed light on the mechanism are conspicuous by their absence: gold(I)-CO is inactive and gold(III)-CO complexes were unknown. We report the synthesis of the first example of an isolable CO complex of Au(III)...
October 2015: Science Advances
Nadia Akawi, Jeremy McRae, Morad Ansari, Meena Balasubramanian, Moira Blyth, Angela F Brady, Stephen Clayton, Trevor Cole, Charu Deshpande, Tomas W Fitzgerald, Nicola Foulds, Richard Francis, George Gabriel, Sebastian S Gerety, Judith Goodship, Emma Hobson, Wendy D Jones, Shelagh Joss, Daniel King, Nikolai Klena, Ajith Kumar, Melissa Lees, Chris Lelliott, Jenny Lord, Dominic McMullan, Mary O'Regan, Deborah Osio, Virginia Piombo, Elena Prigmore, Diana Rajan, Elisabeth Rosser, Alejandro Sifrim, Audrey Smith, Ganesh J Swaminathan, Peter Turnpenny, James Whitworth, Caroline F Wright, Helen V Firth, Jeffrey C Barrett, Cecilia W Lo, David R FitzPatrick, Matthew E Hurles
Discovery of most autosomal recessive disease-associated genes has involved analysis of large, often consanguineous multiplex families or small cohorts of unrelated individuals with a well-defined clinical condition. Discovery of new dominant causes of rare, genetically heterogeneous developmental disorders has been revolutionized by exome analysis of large cohorts of phenotypically diverse parent-offspring trios. Here we analyzed 4,125 families with diverse, rare and genetically heterogeneous developmental disorders and identified four new autosomal recessive disorders...
November 2015: Nature Genetics
Tim Theologis, James Wright
No abstract text is available yet for this article.
September 2015: Gait & Posture
Michael G Crooks, Yvette Hayman, Andrew Innes, James Williamson, Caroline E Wright, Alyn H Morice
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Cough and sputum production are associated with adverse outcomes in COPD and are common during COPD exacerbation (AE-COPD). This study of objective cough monitoring using the Hull Automated Cough Counter and Leicester Cough Monitor software confirms that this system has the ability to detect a significant decrease in cough frequency during AE-COPD convalescence. The ability to detect clinically meaningful change indicates a potential role in home monitoring of COPD patients...
February 2016: Lung
Atle Fretheim, Fang Zhang, Dennis Ross-Degnan, Andrew D Oxman, Helen Cheyne, Robbie Foy, Steve Goodacre, Jeph Herrin, Ngaire Kerse, R James McKinlay, Adam Wright, Stephen B Soumerai
OBJECTIVES: There is often substantial uncertainty about the impacts of health system and policy interventions. Despite that, randomized controlled trials (RCTs) are uncommon in this field, partly because experiments can be difficult to carry out. An alternative method for impact evaluation is the interrupted time-series (ITS) design. Little is known, however, about how results from the two methods compare. Our aim was to explore whether ITS studies yield results that differ from those of randomized trials...
March 2015: Journal of Clinical Epidemiology
Michael Caley, Paramdip Chohan, James Hooper, Nicola Wright
BACKGROUND: NHS Health Checks is a national case-finding and vascular risk assessment programme in England. No research has been published to assess the impact of NHS Health Checks on the prevalence of chronic disease in GP practices. AIM: To examine the impact of NHS Health Checks on the prevalence of hypertension, coronary heart disease (CHD), chronic kidney disease (CKD), atrial fibrillation (AF), and diabetes within practices, and compare this with usual medical care...
August 2014: British Journal of General Practice: the Journal of the Royal College of General Practitioners
Tina L Bloom, Nancy E Glass, James Case, Courtney Wright, Kimberly Nolte, Lindsay Parsons
BACKGROUND: Intimate partner violence (IPV) in pregnancy is common and harmful to maternal-child health. Safety planning is the gold standard for intervention, but most abused women never access safety planning. Pregnant women may face increased barriers to safety planning and risk of severe IPV, particularly if they are also rural residents. Internet-based safety planning interventions may be useful, but no such interventions specific to the needs of pregnant women have been developed...
July 2014: Nursing Research
Edna Andrews, Luca Frigau, Clara Voyvodic-Casabo, James Voyvodic, John Wright
BOLD fMRI is often used for the study of human language. However, there are still very few attempts to conduct longitudinal fMRI studies in the study of language acquisition by measuring auditory comprehension and reading. The following paper is the first in a series concerning a unique longitudinal study devoted to the analysis of bi- and multilingual subjects who are: (1) already proficient in at least two languages; or (2) are acquiring Russian as a second/third language. The focus of the current analysis is to present data from the auditory sections of a set of three scans acquired from April, 2011 through April, 2012 on a five-person subject pool who are learning Russian during the study...
2013: Brain Sciences
Michael G Burgess, M Naveed Zafar, Stephen T Horner, George R Clark, L James Wright
Double aza-Michael addition of n-butylamine to the two acrylamide groups of acyclic N(2),N(6)-bis(6-acrylamidopyridin-2-yl)pyridine-2,6-dicarboxamide gives the corresponding macrocycle, H₄L. H₄L has potential coordination pockets associated with the 2,6-dicarboxamide (head) and the butylamine (tail) regions of the macrocycle. Depending on the conditions employed, macrocyclic complexes with palladium(II) coordinated to either the tail or the head of the macrocycle can be isolated. Thus, treatment of H₄L with [PdCl2(NCPh)2] and sodium acetate, or [Pd(OAc)2] gives the closely related "tail-coordinated" complexes [PdCl(H3L)] (3a) or [Pd(OAc)(H3L)] (3b), respectively...
December 7, 2014: Dalton Transactions: An International Journal of Inorganic Chemistry
James Antonaglia, Wendelin J Wright, Xiaojun Gu, Rachel R Byer, Todd C Hufnagel, Michael LeBlanc, Jonathan T Uhl, Karin A Dahmen
For the first time in metallic glasses, we extract both the exponents and scaling functions that describe the nature, statistics, and dynamics of slip events during slow deformation, according to a simple mean field model. We model the slips as avalanches of rearrangements of atoms in coupled shear transformation zones (STZs). Using high temporal resolution measurements, we find the predicted, different statistics and dynamics for small and large slips thereby excluding self-organized criticality. The agreement between model and data across numerous independent measures provides evidence for slip avalanches of STZs as the elementary mechanism of inhomogeneous deformation in metallic glasses...
April 18, 2014: Physical Review Letters
Mark B Tracy, Dharmesh Shah, Murray Hinder, Jan Klimek, James Marceau, Audrey Wright
AIM: To determine changes in respiratory mechanics when chest compressions are added to mask ventilation, as recommended by the International Liaison Committee on Resuscitation (ILCOR) guidelines for newborn infants. METHODS: Using a Laerdal Advanced Life Support leak-free baby manikin and a 240-mL self-inflating bag, 58 neonatal staff members were randomly paired to provide mask ventilation, followed by mask ventilation with chest compressions with a 1:3 ratio, for two minutes each...
May 2014: Acta Paediatrica
Donald S Rubenstein, Lawrence T Weston, James Kneller, Christopher Wright, Hang Yin
The Riata 1590 lead model contains both electrically active cables (AC) and filler cables (FC) that run in pairs within lumens along the lead body. FC are yet to be described as lead components that may be externalized from either external abrasion or inside-out abrasion seen in the recalled St. Jude leads. Externalization of FC would not be expected to develop any electrical abnormality during routine ICD and lead evaluations. FC are fixed at their ends only with a silicone adhesive compared to mechanical crimps for AC...
August 2013: Journal of Cardiovascular Electrophysiology
James Anderson, Drew Wright, Khalid Meksem
In the modern age of genetic research there is a constant search for ways to improve the efficiency of plant selection. The most recent technology that can result in a highly efficient means of selection and still be done at a low cost is through plant selection directed by simple sequence repeats (SSRs or microsatellites). The molecular markers are used to select for certain desirable plant traits without relying on ambiguous phenotypic data. The best way to detect these is the use of gel electrophoresis. Gel electrophoresis is a common technique in laboratory settings which is used to separate deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) by size...
2013: Methods in Molecular Biology
Fleur Horner, James L Bilzon, Mark Rayson, Sam Blacker, Victoria Richmond, James Carter, Anthony Wright, Alan Nevill
This study developed a multivariate model to predict free-living energy expenditure (EE) in independent military cohorts. Two hundred and eighty-eight individuals (20.6 ± 3.9 years, 67.9 ± 12.0 kg, 1.71 ± 0.10 m) from 10 cohorts wore accelerometers during observation periods of 7 or 10 days. Accelerometer counts (PAC) were recorded at 1-minute epochs. Total energy expenditure (TEE) and physical activity energy expenditure (PAEE) were derived using the doubly labelled water technique. Data were reduced to n = 155 based on wear-time...
2013: Journal of Sports Sciences
Jane Burch, Susan Griffin, Claire McKenna, Simon Walker, James Paton, Kath Wright, Nerys Woolacott
Following a licence extension to include those aged 6-11 years, the National Institute for Health and Clinical Excellence (NICE) invited the manufacturer of omalizumab (Novartis Pharmaceuticals UK) to submit evidence for the clinical and cost effectiveness of this drug for patients with severe persistent allergic asthma in this age bracket. NICE had previously considered the use of omalizumab in patients aged 12 years and over. The Centre for Reviews and Dissemination (CRD) and the Centre for Health Economics (CHE) at the University of York were commissioned as the Evidence Review Group (ERG) to critically appraise the evidence presented by the manufacturer...
November 1, 2012: PharmacoEconomics
Catherine Godfraind, Joanna M Kaczmarska, Mehmet Kocak, James Dalton, Karen D Wright, Robert A Sanford, Fredrick A Boop, Amar Gajjar, Thomas E Merchant, David W Ellison
No reliable classification is in clinical use for the therapeutic stratification of children with ependymoma, such that disease risk might be identified and patients treated to ensure a combination of maximal cure rates and minimal adverse therapeutic effects. This study has examined associations between clinicopathologic and cytogenetic variables and outcome in a trial cohort of children with ependymoma, with the aim of defining a practical scheme for stratifying this heterogeneous tumor. Intracranial ependymomas (n = 146) from children treated on the RT1 trial at St...
August 2012: Acta Neuropathologica
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