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lactoferricin

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https://www.readbyqxmd.com/read/29761938/lactoferricin-b-reverses-cisplatin-resistance-in-head-and-neck-squamous-cell-carcinoma-cells-through-targeting-pd-l1
#1
Pei Zhang, Jinzhong Liu, Wenlu Li, Shanshan Li, Xinguang Han
Head and neck squamous cell carcinoma (HNSCC) ranks among the top most common cancers with a poor prognosis. The mechanism of chemoresistance is still not well known. This study is to investigate the programmed death-ligand 1 (PD-L1) expression in HNSCC, and test the effect of lactoferricin B (LfcinB) on chemoresistance and its mechanism. We analyzed 510 HNSCC patients in TCGA database and investigated how CD274 expression was related to patient prognosis. PD-L1 was verified from HNSCC samples at local hospital with immunohistochemistry...
May 15, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29669808/lactoferrin-is-a-natural-inhibitor-of-plasminogen-activation
#2
Alexander Zwirzitz, Michael Reiter, Rostislav Skrabana, Anna Ohradanova-Repic, Otto Majdic, Marianna Gutekova, Ondrej Cehlar, Eva Petrovčíková, Eva Kutejova, Gerold Stanek, Hannes Stockinger, Vladimir Leksa
The plasminogen system is essential for dissolution of fibrin clots, and in addition, it is involved in a wide variety of other physiological processes, including proteolytic activation of growth factors, cell migration, and removal of protein aggregates. On the other hand, uncontrolled plasminogen activation contributes to many pathological processes, e.g. tumor cells' invasion in cancer progression. Moreover, some virulent bacterial species, e.g. Streptococci or Borrelia, bind human plasminogen and hijack the host's plasminogen system to penetrate tissue barriers...
April 18, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29619665/expression-and-purification-of-the-main-component-contained-in-camel-milk-and-its-antimicrobial-activities-against-bacterial-plant-pathogens
#3
Abbas Tanhaeian, Farajollah Shahriari Ahmadi, Mohammad Hadi Sekhavati, Mojtaba Mamarabadi
Lactoferrin is the most dominant protein in milk after casein. This protein plays a crucial role in many biological processes including the regulation of iron metabolism, induction and modulation of the immune system, the primary defense against microorganisms, inhibiting lipid peroxidation and presenting antimicrobial activity against various pathogens such as parasites, fungi, bacteria, and viruses. The major antimicrobial effect of lactoferrin is related to its N-terminal tail where different peptides for instance lactoferricin and lactoferrampin which are important for their antimicrobial abilities are present...
April 4, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29589540/-lactoferrin-and-peptide-derivatives-antimicrobial-agents-with-potential-use-in-nonspecific-immunity-modulation
#4
Maria Elisa Drago-Serrano, Rafael Campos-Rodriguez, Julio Cesar Carrero, Mireya de la Garza
Lactoferrin (Lf) is a conserved cationic non-heme glycoprotein that is part of the innate immune defense system of mammals. Lf is present in colostrum, milk and mucosal sites, and it is also produced by polymorphonuclear neutrophils and secreted at infection sites. Lf and Lf N-terminus peptide-derivatives named lactoferricins (Lfcins) are molecules with microbiostatic and microbicidal action in a wide array of pathogens. In addition, they display regulatory properties on components of nonspecific immunity, including toll-like receptors, pro- and anti-inflammatory cytokines, and reactive oxygen species...
March 27, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29551999/design-synthesis-and-evaluation-of-branched-rrwqwr-based-peptides-as-antibacterial-agents-against-clinically-relevant-gram-positive-and-gram-negative-pathogens
#5
Sandra C Vega, Diana A Martínez, María Del S Chalá, Hernán A Vargas, Jaiver E Rosas
Multidrug resistance of pathogenic bacteria has become a public health crisis that requires the urgent design of new antibacterial drugs such as antimicrobial peptides (AMPs). Seeking to obtain new, lactoferricin B (LfcinB)-based synthetic peptides as viable early-stage candidates for future development as AMPs against clinically relevant bacteria, we designed, synthesized and screened three new cationic peptides derived from bovine LfcinB. These peptides contain at least one RRWQWR motif and differ by the copy number (monomeric, dimeric or tetrameric) and structure (linear or branched) of this motif...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29455278/a-review-of-the-design-and-modification-of-lactoferricins-and-their-derivatives
#6
Ya Hao, Na Yang, Da Teng, Xiumin Wang, Ruoyu Mao, Jianhua Wang
Lactoferricin (Lfcin), a multifunction short peptide with a length of 25 residues, is derived from the whey protein lactoferrin by acidic pepsin hydrolysis. It has potent nutritional enhancement, antimicrobial, anticancer, antiviral, antiparasitic, and anti-inflammatory activities. This review describes the research advantages of the above biological functions, with attention to the molecular design and modification of Lfcin. In this examination of design and modification studies, research on the identification of Lfcin active derivatives and crucial amino acid residues is also reviewed...
February 17, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29177937/biosynthesis-of-2-aminooctanoic-acid-and-its-use-to-terminally-modify-a-lactoferricin-b-peptide-derivative-for-improved-antimicrobial-activity
#7
Sarah A Almahboub, Tanja Narancic, Marc Devocelle, Shane T Kenny, William Palmer-Brown, Cormac Murphy, Jasmina Nikodinovic-Runic, Kevin E O'Connor
Terminal modification of peptides is frequently used to improve their hydrophobicity. While N-terminal modification with fatty acids (lipidation) has been reported previously, C-terminal lipidation is limited as it requires the use of linkers. Here we report the use of a biocatalyst for the production of an unnatural fatty amino acid, (S)-2-aminooctanoic acid (2-AOA) with enantiomeric excess > 98% ee and the subsequent use of 2-AOA to modify and improve the activity of an antimicrobial peptide. A transaminase originating from Chromobacterium violaceum was employed with a conversion efficiency 52-80% depending on the ratio of amino group donor to acceptor...
January 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29069749/-in-vitro-and-in-vivo-cytotoxic-activity-of-human-lactoferricin-derived-antitumor-peptide-r-dim-p-lf11-334-on-human-malignant-melanoma
#8
Sabrina Riedl, Beate Rinner, Helmut Schaider, Bernadette Liegl-Atzwanger, Katharina Meditz, Julia Preishuber-Pflügl, Sarah Grissenberger, Karl Lohner, Dagmar Zweytick
Di-peptides derived from the human host defense peptide lactoferricin were previously described to specifically interact with the negatively charged lipid phosphatidylserine exposed by cancer cells. In this study one further derivative, namely R-DIM-P-LF11-334 is shown to exhibit even increased cancer toxicity in vitro and in vivo while non-neoplastic cells are not harmed. In liposomal model systems composed of phosphatidylserine mimicking cancerous and phosphatidylcholine mimicking non-cancerous membranes the specific interaction with the cancer marker PS was confirmed by specific induction of membrane perturbation and permeabilization in presence of the peptide...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28961215/antibacterial-synthetic-peptides-derived-from-bovine-lactoferricin-exhibit-cytotoxic-effect-against-mda-mb-468-and-mda-mb-231-breast-cancer-cell-lines
#9
Yerly Vargas Casanova, Jorge Antonio Rodríguez Guerra, Yadi Adriana Umaña Pérez, Aura Lucía Leal Castro, Giovanni Almanzar Reina, Javier Eduardo García Castañeda, Zuly Jenny Rivera Monroy
Linear, dimeric, tetrameric, and cyclic peptides derived from lactoferricin B, containing the RRWQWR motif, were designed, synthesized, purified, and characterized using RP-HPLC chromatography and MALDI-TOF mass spectrometry. The antibacterial activity of the designed peptides against E. coli (ATCC 11775 and 25922) and their cytotoxic effect against MDA-MB-468 and MDA-MB-231 breast cancer cell lines were evaluated. Dimeric and tetrameric peptides showed higher antibacterial activity in both bacteria strains than linear peptides...
September 29, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28875176/lactoferricin-peptides-increase-macrophages-capacity-to-kill-mycobacterium-avium
#10
Tânia Silva, Ana C Moreira, Kamran Nazmi, Tânia Moniz, Nuno Vale, Maria Rangel, Paula Gomes, Jan G M Bolscher, Pedro N Rodrigues, Margarida Bastos, Maria Salomé Gomes
Mycobacterial infections cause a significant burden of disease and death worldwide. Their treatment is long, toxic, costly, and increasingly prone to failure due to bacterial resistance to currently available antibiotics. New therapeutic options are thus clearly needed. Antimicrobial peptides represent an important source of new antimicrobial molecules, both for their direct activity and for their immunomodulatory potential. We have previously reported that a short version of the bovine antimicrobial peptide lactoferricin with amino acids 17 to 30 (LFcin17-30), along with its variants obtained by specific amino acid substitutions, killed Mycobacterium avium in broth culture...
July 2017: MSphere
https://www.readbyqxmd.com/read/28846026/lactoferricin-verbascoside-topical-emulsion-a-possible-alternative-treatment-for-atopic-dermatitis-in-dogs
#11
Elena Biasibetti, Natascia Bruni, Mauro Bigliati, Maria Teresa Capucchio
Atopic dermatitis affects 3-15% of the general dog population and it has been diagnosed by veterinarians up to 58% of dogs affected with skin disease. It is usually a life-long pathology which can be controlled, but it can be seldom cured. The present investigation describes a case study in which lactoferricin and verbascoside are part of a formulation to obtain a dermatological lotion for canine dermatitis treatment. The study was an open-label trial design of two-week treatment. Thirty-eight dogs (23 females and 15 males), with atopic dermatitis and secondary bacterial or yeast overgrowth have been included...
August 28, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28828981/the-primary-mechanism-of-cellular-internalization-for-a-short-cell-penetrating-peptide-as-a-nano-scale-delivery-system
#12
Betty R Liu, Yue-Wern Huang, Mallikarjuna Korivi, Shih-Yen Lo, Robert S Aronstam, Han-Jung Lee
BACKGROUND: Development of effective drug delivery systems (DDS) is a critical issue in health care and medicine. Advances in molecular biology and nanotechnology have allowed the introduction of nanomaterial-based drug delivery systems. Cell-penetrating peptides (CPPs) can form the basis of drug delivery systems by virtue of their ability to support the transport of cargoes into the cell. Potential cargoes include proteins, DNA, RNA, liposomes, and nanomaterials. These cargoes generally retain their bioactivities upon entering cells...
2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28823045/killing-activity-of-lfchimera-on-periodontopathic-bacteria-and-multispecies-oral-biofilm-formation-in-vitro
#13
Sopita Ruangcharoen, Waraporn Suwannarong, Marie Rossini Carmela T Lachica, Jan G M Bolscher, Kamran Nazmi, Watcharee Khunkitti, Suwimol Taweechaisupapong
Lactoferrin chimera (LFchimera), a heterodimeric peptide containing lactoferrampin (LFampin265-284) and a part of lactoferricin (LFcin17-30), possesses a broad spectrum of antimicrobial activity. However, there is no report on the inhibitory effects of LFchimera against multispecies oral biofilms. This study aimed to determine the effects of LFchimera in comparison to chlorhexidine digluconate (CHX) and minocycline hydrochloride (MH), on in vitro multispecies biofilms derived from subgingival plaque of periodontitis patients harboring Aggregatibacter actinomycetemcomitans...
August 19, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28752991/entry-of-a-six-residue-antimicrobial-peptide-derived-from-lactoferricin-b-into-single-vesicles-and-escherichia-coli-cells-without-damaging-their-membranes
#14
Md Moniruzzaman, Md Zahidul Islam, Sabrina Sharmin, Hideo Dohra, Masahito Yamazaki
Lactoferricin B (LfcinB) and shorter versions of this peptide have antimicrobial activity. However, the elementary processes of interactions of these peptides with lipid membranes and bacteria are still not well understood. To elucidate the mechanism of their antimicrobial activity, we investigated the interactions of LfcinB (4-9) (its sequence of RRWQWR) with Escherichia coli cells and giant unilamellar vesicles (GUVs). LfcinB (4-9) and lissamine rhodamine B red-labeled LfcinB (4-9) (Rh-LfcinB (4-9)) did not induce an influx of a membrane-impermeant fluorescent probe, SYTOX green, from the outside of E...
August 22, 2017: Biochemistry
https://www.readbyqxmd.com/read/28570999/in-vitro-and-in-vivo-cytotoxic-activity-of-human-lactoferricin-derived-antitumor-peptide-r-dim-p-lf11-334-on-human-malignant-melanoma
#15
Sabrina Riedl, Beate Rinner, Helmut Schaider, Bernadette Liegl-Atzwanger, Katharina Meditz, Julia Preishuber-Pflügl, Sarah Grissenberger, Karl Lohner, Dagmar Zweytick
Di-peptides derived from the human host defense peptide lactoferricin were previously described to specifically interact with the negatively charged lipid phosphatidylserine exposed by cancer cells. In this study one further derivative, namely R-DIM-P-LF11-334 is shown to exhibit even increased cancer toxicity in vitro and in vivo while non-neoplastic cells are not harmed.In liposomal model systems composed of phosphatidylserine mimicking cancerous and phosphatidylcholine mimicking non-cancerous membranes the specific interaction with the cancer marker PS was confirmed by specific induction of membrane perturbation and permeabilization in presence of the peptide...
May 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28358840/a-tetrameric-peptide-derived-from-bovine-lactoferricin-as-a-potential-therapeutic-tool-for-oral-squamous-cell-carcinoma-a-preclinical-model
#16
Víctor Alfonso Solarte, Paulette Conget, Jean-Paul Vernot, Jaiver Eduardo Rosas, Zuly Jenny Rivera, Javier Eduardo García, Martha Ligia Arango-Rodríguez
Oral squamous cell carcinoma is the fifth most common epithelial cancer in the world, and its current clinical treatment has both low efficiency and poor selectivity. Cationic amphipathic peptides have been proposed as new drugs for the treatment of different types of cancer. The main goal of the present work was to determine the potential of LfcinB(20-25)4, a tetrameric peptide based on the core sequence RRWQWR of bovine lactoferricin LfcinB(20-25), for the treatment of OSCC. In brief, OSCC was induced in the buccal pouch of hamsters by applying 7,12-Dimethylbenz(a)anthracene, and tumors were treated with one of the following peptides: LfcinB(20-25)4, LfcinB(20-25), or vehicle (control)...
2017: PloS One
https://www.readbyqxmd.com/read/28350085/the-lactoferricin-b-derived-peptide-lfb17-34-induces-melanogenesis-in-b16f10-cells
#17
Hsiu-Chin Huang, Hsuan Lin, Min-Chuan Huang
Lactoferricin B (LfcinB), a peptide of bovine lactoferrin (LfB), exhibits multiple biological functions, including antimicrobial, antiviral, antioxidant and immunomodulatory activities. However, the role of LfcinB-related peptides in melanogenesis remains unclear. In this study, a set of five LfcinB-related peptides was examined. We found that LfB17‑34, an 18-mer LfcinB-derived peptide, increased melanogenesis in B16F10 melanoma cells without significantly affecting cell viability. LfB17‑34 increased in vitro tyrosinase activity and melanin content in a dose-dependent manner...
February 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28287494/synthetic-peptides-derived-from-bovine-lactoferricin-exhibit-antimicrobial-activity-against-e-coli-atcc-11775-s-maltophilia-atcc-13636-and-s-enteritidis-atcc-13076
#18
Nataly De Jesús Huertas Méndez, Yerly Vargas Casanova, Anyelith Katherine Gómez Chimbi, Edith Hernández, Aura Lucia Leal Castro, Javier Mauricio Melo Diaz, Zuly Jenny Rivera Monroy, Javier Eduardo García Castañeda
Linear, dimeric, tetrameric, and cyclic peptides derived from lactoferricin B-containing non-natural amino acids and the RWQWR motif were synthesized, purified, and characterized using RP-HPLC, MALDI-TOF mass spectrometry, and circular dichroism. The antibacterial activity of peptides against Escherichia coli ATCC 11775, Stenotrophomonas maltophilia ATCC 13636, and Salmonella enteritidis ATCC 13076 was evaluated. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined...
March 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28287172/killing-of-staphylococcus-aureus-and-salmonella-enteritidis-and-neutralization-of-lipopolysaccharide-by-17-residue-bovine-lactoferricins-improved-activity-of-trp-ala-containing-molecules
#19
Ya Hao, Na Yang, Xiumin Wang, Da Teng, Ruoyu Mao, Xiao Wang, Zhanzhan Li, Jianhua Wang
Bovine lactoferricin (LfcinB) has potent antibacterial, antifungal and antiparasitic activities but is also hemolytic. Our objective was to identify LfcinB17-31 derivatives with reduced hemolysis and improved antimicrobial activity via substituting Cys3, Arg4, Gln7, Met10, and Gly14 with more hydrophobic residues. Two peptides, Lfcin4 and Lfcin5, showed higher activity against Staphylococcus aureus and Salmonella enteritidis and lower hemolytic activity than the parent peptide LfcinB17-31. These peptides permeabilized the outer and inner membranes of S...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28204812/the-lactoferricin-b-derived-peptide-lfb17-34-induces-melanogenesis-in-b16f10-cells
#20
Hsiu-Chin Huang, Hsuan Lin, Min-Chuan Huang
Lactoferricin B (LfcinB), a peptide of bovine lactoferrin (LfB), exhibits multiple biological functions, including antimicrobial, antiviral, antioxidant and immunomodulatory activities. However, the role of LfcinB-related peptides in melanogenesis remains unclear. In this study, a set of five LfcinB-related peptides was examined. We found that LfB17‑34, an 18-mer LfcinB-derived peptide, increased melanogenesis in B16F10 melanoma cells without significantly affecting cell viability. LfB17‑34 increased in vitro tyrosinase activity and melanin content in a dose-dependent manner...
March 2017: International Journal of Molecular Medicine
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