keyword
https://read.qxmd.com/read/38133330/antibiotic-resistance-genes-virulence-factors-and-biofilm-formation-in-coagulase-negative-staphylococcus-spp-isolates-from-european-hakes-merluccius-merluccius-l-caught-in-the-northeast-atlantic-ocean
#21
JOURNAL ARTICLE
Lara Díaz-Formoso, Vanessa Silva, Diogo Contente, Javier Feito, Pablo E Hernández, Juan Borrero, Gilberto Igrejas, Rosa Del Campo, Estefanía Muñoz-Atienza, Patrícia Poeta, Luis M Cintas
The indiscriminate use of antibiotics has contributed to the dissemination of multiresistant bacteria, which represents a public health concern. The aim of this work was to characterize 27 coagulase-negative staphylococci (CoNS) isolated from eight wild Northeast Atlantic hakes ( Merluccius merluccius , L.) and taxonomically identified as Staphylococcus epidermidis ( n = 16), Staphylococcus saprophyticus ( n = 4), Staphylococcus hominis ( n = 3), Staphylococcus pasteuri ( n = 2), Staphylococcus edaphicus ( n = 1), and Staphylococcus capitis ( n = 1)...
December 13, 2023: Pathogens
https://read.qxmd.com/read/38125494/new-lignan-glycosides-from-justicia-secunda-vahl-acanthaceae-with-antimicrobial-and-antiparasitic-properties
#22
JOURNAL ARTICLE
Viviane Flore Kamlo Kamso, Yanick Kevin Dongmo Melogmo, Billy Toussie Tchegnitegni, Mariscal Brice Tchatat Tali, Darline Dize, Cyrille Njampa Ngansop, Pantaléon Ambassa, Judith Laure Ouete Nantchouang, Ingrid Simo Konga, Fabrice Fekam Boyom, Bonaventure Tchaleu Ngadjui, Ghislain Wabo Fotso
Three new lignan glucosides, namely, justisecundosides A ( 1 ), B ( 2a ), and C ( 2b ), were isolated from the whole plant of Justicia secunda together with seven known compounds ( 3-9 ). Their structures were established based on a comprehensive analysis of HR-ESI-MS, IR, UV, and CD, in conjunction with their 1D and 2D-NMR data. A putative biogenetic pathway of compounds 1-2a,b from coniferyl alcohol was proposed. In addition, the antimicrobialactivities of the extract, fractions, and some isolated compounds were assessed against multiresistant bacterial and fungal strains...
December 2023: Heliyon
https://read.qxmd.com/read/38004803/avirulent-isolates-of-penicillium-chrysogenum-to-control-the-blue-mold-of-apple-caused-by-p-expansum
#23
JOURNAL ARTICLE
Holly P Bartholomew, Dianiris Luciano-Rosario, Michael J Bradshaw, Verneta L Gaskins, Hui Peng, Jorge M Fonseca, Wayne M Jurick
Blue mold is an economically significant postharvest disease of pome fruit that is primarily caused by Penicillium expansum . To manage this disease and sustain product quality, novel decay intervention strategies are needed that also maintain long-term efficacy. Biocontrol organisms and natural products are promising tools for managing postharvest diseases. Here, two Penicillium chrysogenum isolates, 404 and 413, were investigated as potential biocontrol agents against P. expansum in apple. Notably, 404 and 413 were non-pathogenic in apple, yet they grew vigorously in vitro when compared to the highly aggressive P...
November 17, 2023: Microorganisms
https://read.qxmd.com/read/37971152/antibiotic-resistances-of-pseudomonas-aeruginosa-and-acinetobacter-baumannii-in-urine-cultures-experience-in-a-hospital-of-southeast-spain
#24
JOURNAL ARTICLE
Horacio Requena-Cabello, Enrique Rodríguez-Guerrero, Manuela Expósito-Ruiz, José María Navarro-Marí, Jose Gutierrez-Fernandez
The objectives of this study were to perform a systematic review of publications between 2010 and 2021 on the antibiotic resistance of Pseudomonas aeruginosa and Acinetobacter baumannii from urinary tract infections and to analyze changes over time in hospital urine cultures from 2016 through 2021. The literature was searched, and a retrospective cross-sectional descriptive study was performed in the hospital. Out of 21 838 positive urine cultures, 3.86% were due to P. aeruginosa and 0.44% were due to A...
November 16, 2023: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/37967733/psk41-pgo1-family-conjugative-plasmids-of-staphylococcus-aureus-encode-a-cryptic-repressor-of-replication
#25
JOURNAL ARTICLE
Alvina Sarosh, Stephen M Kwong, Slade O Jensen, Faith Northern, William G Walton, Thomas C Eakes, Matthew R Redinbo, Neville Firth, Krystle J McLaughlin
The majority of large multiresistance plasmids of Staphylococcus aureus utilise a RepA_N-type replication initiation protein, the expression of which is regulated by a small antisense RNA (RNAI) that overlaps the rep mRNA leader. The pSK41/pGO1-family of conjugative plasmids additionally possess a small (86 codon) divergently transcribed ORF (orf86) located upstream of the rep locus. The product of pSK41 orf86 was predicted to have a helix-turn-helix motif suggestive of a likely function in transcriptional repression...
November 13, 2023: Plasmid
https://read.qxmd.com/read/37961817/theoretical-study-of-the-interaction-between-the-antibiotic-linezolid-and-the-active-site-of-the-50s-ribosomal-subunit-of-the-bacterium-haloarcula-marismortui
#26
JOURNAL ARTICLE
Giulia Saneti Grandini, Nelson Henrique Morgon, Aguinaldo Robinson de Souza
First antibiotic in the oxazolidinone class, linezolid fights gram-positive multiresistant bacteria by inhibiting protein synthesis through its interaction with the 50S subunit of the functional bacterial ribosome. For its antimicrobial action, it is necessary that its chiral carbon located in the oxazolidinone ring is in the S-conformation. Computational calculation at time-dependent density functional theory methodology, ultraviolet-visible (UV-Vis), and electronic circular dichroism spectra was obtained for noncomplexed and complexed forms of linezolid to verify the possible chirality of nitrogen atom in the acetamide group of the molecule...
November 14, 2023: Chirality
https://read.qxmd.com/read/37944805/toxigenic-characterization-spoilage-potential-and-antimicrobial-susceptibility-of-coagulase-positive-staphylococcus-species-isolated-from-minas-frescal-cheese
#27
JOURNAL ARTICLE
J C Ribeiro, E M Rodrigues, B P Dias, E P R da Silva, B Alexandrino, C M O Lobo, R Tamanini, A A Alfieri
This study aimed to identify coagulase-positive staphylococci (CPS) species from 21 samples of clandestine Minas Frescal cheese, investigate the potential for deterioration in psychrotrophic and mesophilic conditions, verify the toxigenic potential of Staphylococcus aureus, and determine the antimicrobial susceptibility profile of toxigenic S. aureus. Species determination was performed based on the detection of β-hemolysis in 5% ovine blood agar; fermentation of mannitol, maltose, and trehalose sugars; and production of acetoin...
November 7, 2023: Journal of Dairy Science
https://read.qxmd.com/read/37897148/questioning-the-14-day-dogma-in-candidemia-treatment-duration
#28
REVIEW
Jon Salmanton-García, Ilana Reinhold, Juergen Prattes, Nico Bekaan, Philipp Koehler, Oliver A Cornely
The growing threat of antimicrobial resistance (AMR) is a global concern. With AMR directly causing 1.27 million deaths in 2019 and projections of up to 10 million annual deaths by 2050, optimising infectious disease treatments is imperative. Prudent antimicrobial use, including treatment duration, can mitigate AMR emergence. This is particularly critical in candidemia, a severe condition with a 45% crude mortality rate, as the 14-day minimum treatment period has not been challenged in randomised comparison...
January 2024: Mycoses
https://read.qxmd.com/read/37896155/lipophosphonoxins-a-novel-group-of-broad-spectrum-antibacterial-compounds
#29
REVIEW
Viktor Šebek, Pavel Anzenbacher, Dominik Rejman, Alena Špičáková, Milan Kolář
Lipophosphonoxins (LPPOs) represent a new group of membrane-targeting antibiotics. Three generations of LPPOs have been described: First-generation LPPOs, second-generation LPPOs, and LEGO-LPPOs. All three generations have a similar mode of bactericidal action of targeting and disrupting the bacterial cytoplasmic membrane of prokaryotic cells, with limited effect on eukaryotic cells. First-generation LPPOs showed excellent bactericidal activity against Gram-positive species, including multiresistant strains...
September 28, 2023: Pharmaceutics
https://read.qxmd.com/read/37893917/identification-typing-and-drug-resistance-analysis-of-escherichia-coli-in-two-different-types-of-broiler-farms-in-hebei-province
#30
JOURNAL ARTICLE
Chuncai Liang, Huan Cui, Ligong Chen, Hailong Zhang, Cheng Zhang, Juxiang Liu
Hebei Province is an important area for breeding broiler chickens in China, but the antimicrobial resistance and prevalence of Escherichia coli ( E. coli ) are still unclear. A total of 180 cloacal samples from broiler farms in Hebei Province were collected and used for the isolation and identification of E. coli . The isolates were subjected to resistance phenotyping, resistance profiling, and genotyping, and some multiresistant strains were subjected to multilocus sequence typing (MLST). The results showed that 175 strains were isolated...
October 13, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/37892664/ten-issues-to-update-in-nosocomial-or-hospital-acquired-pneumonia-an-expert-review
#31
REVIEW
Francisco Javier Candel, Miguel Salavert, Angel Estella, Miquel Ferrer, Ricard Ferrer, Julio Javier Gamazo, Carolina García-Vidal, Juan González Del Castillo, Víctor José González-Ramallo, Federico Gordo, Manuel Mirón-Rubio, Javier Pérez-Pallarés, Cristina Pitart, José Luís Del Pozo, Paula Ramírez, Pedro Rascado, Soledad Reyes, Patricia Ruiz-Garbajosa, Borja Suberviola, Pablo Vidal, Rafael Zaragoza
Nosocomial pneumonia, or hospital-acquired pneumonia (HAP), and ventilator-associated pneumonia (VAP) are important health problems worldwide, with both being associated with substantial morbidity and mortality. HAP is currently the main cause of death from nosocomial infection in critically ill patients. Although guidelines for the approach to this infection model are widely implemented in international health systems and clinical teams, information continually emerges that generates debate or requires updating in its management...
October 14, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37887221/emergence-and-genomic-features-of-a-mcr-1-escherichia-coli-from-duck-in-hungary
#32
JOURNAL ARTICLE
Ama Szmolka, Ákos Gellért, Dóra Szemerits, Fanni Rapcsák, Sándor Spisák, András Adorján
Plasmids carrying high-risk resistance mechanisms in pathogenic E. coli have gained particular attention in veterinary medicine, especially since the discovery of the colistin resistance gene, mcr-1 . Here, we provide the first evidence of its emergence and describe the complete mcr-1 plasmid sequence of a multi-resistant avian pathogenic E. coli (APEC) strain from waterfowl in Hungary. Whole-genome sequencing analysis and core-genome MLST were performed to characterize the genome structure of the mcr-1 plasmid and to reveal the phylogenetic relation between the Hungarian duck strain Ec45-2020 and the internationally circulating mcr-1 -positive E...
October 7, 2023: Antibiotics
https://read.qxmd.com/read/37887187/enterococci-isolated-from-one-day-old-chickens-and-their-phenotypic-susceptibility-to-antimicrobials-in-the-czech-republic
#33
JOURNAL ARTICLE
Jaroslav Bzdil, Vladimir Sladecek, David Senk, Petr Stolar, Zuzana Waicova, Nela Kollertova, Monika Zouharova, Katarina Matiaskova, Petr Linhart, Katerina Nedbalcova
Our study describes the prevalence and spectrum of enterococci isolated from one-day-old chickens in the Czech Republic, their level of antimicrobial resistance, and the occurrence of multiresistance. Over a 24-month period from 1 August 2021 to 31 July 2023, a total of 464 mixed samples of one-day-old chicken organs were examined during routine inspections at 12 randomly selected poultry farms in the Czech Republic. The samples were processed via cultivation methods and suspected strains were confirmed using the MALDI-TOF Mass Spectrometry method...
September 27, 2023: Antibiotics
https://read.qxmd.com/read/37886890/impact-of-cystic-fibrosis-multidisciplinary-virtual-clinics-on-patient-experience-time-commitments-and-costs
#34
JOURNAL ARTICLE
Jody M Bell, Tiffany J Dwyer, Michelle Cunich, Ruth L Dentice, Owen Hutchings, Helen E Jo, Edmund M Lau, Wai Y Lee, Samantha A Nolan, Phillip Munoz, Freya Raffan, Karishma Shah, Miranda Shaw, Nicole A Taylor, Simone K Visser, Veronica A Yozghatlian, Keith K H Wong, Sheila Sivam
BACKGROUND AND AIMS: The experience of outpatient care may differ for select patient groups. This prospective study evaluates the adult patient experience of multidisciplinary outpatient cystic fibrosis (CF) care with videoconferencing through telehealth compared with face-to-face care the year prior. METHODS: People with CF without a lung transplant were recruited. Patient-reported outcomes were obtained at commencement and 12 months into the study, reflecting both their face-to-face and telehealth through videoconferencing experience, respectively...
October 27, 2023: Internal Medicine Journal
https://read.qxmd.com/read/37886663/study-of-the-antimicrobial-activity-of-cationic-carbosilane-dendrimers-against-clinical-strains-of-multidrug-resistant-bacteria-and-their-biofilms
#35
JOURNAL ARTICLE
Marcos Hernando-Gozalo, John Jairo Aguilera-Correa, Carlos Rescalvo-Casas, Laura Seijas-Pereda, Carlos García-Bertolín, Francisco Javier de la Mata, Javier Sánchez-Nieves, Juan Cuadros, Ramón Pérez-Tanoira
INTRODUCTION: Antimicrobial Resistance is a serious public health problem, which is aggravated by the ability of the microorganisms to form biofilms. Therefore, new therapeutic strategies need to be found, one of them being the use of cationic dendritic systems (dendrimers and dendrons). METHODS: The aim of this study is to analyze the in vitro antimicrobial efficacy of six cationic carbosilane (CBS) dendrimers and one dendron with peripheral ammonium groups against multidrug-resistant bacteria, some of them isolated hospital strains, and their biofilms...
2023: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/37874524/wild-and-partially-synanthropic-bird-yeast-diversity-in-vitro-virulence-and-antifungal-susceptibility-of-candida-parapsilosis-and-candida-tropicalis-strains-isolated-from-feces
#36
JOURNAL ARTICLE
Anna Glushakova, Aleksey Kachalkin
Yeast complexes in the fecal samples of wild (Dendrocopos major, Picus viridis) and partially synanthropic (Bombycilla garrulus, Garrulus glandarius, Pica pica, and Pyrrhula pyrrhula) birds were studied in a forest ecosystem during winter. A total of 18 yeast species were identified: 16 ascomycetes and two basidiomycetes belonging to five subphyla of fungi: Saccharomycotina (15), Pezizomycotina (1), Agaricomycotina (1), and Pucciniomycotina (1). Most yeast species were found in the fecal samples of P. pyrrhula (Candida parapsilosis, C...
October 24, 2023: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://read.qxmd.com/read/37833638/fosfomycin-induced-agranulocytosis-a-case-report-and-review-of-the-literature
#37
JOURNAL ARTICLE
Elodie Matusik, Julien Demanet, Isabelle Alves, Alina Tone, Nicolas Ettahar, Justine Lemtiri, Camille Potey, Sophie Gautier, Fabien Lambiotte, Louise Gaboriau
BACKGROUND: The intravenous form of fosfomycin, a bactericide antibiotic used to treat multiresistant bacterial infections is little prescribed. The most common reported adverse effects are hypokaliemia and hypernatremia. We describe a case of agranulocytosis, a rarely described side effect that may be fatal. CASE PRESENTATION: A 45 year-old woman was admitted to the intensive care unit for post-surgical meningitis following meningioma resection. Meropenem and vancomycin were first introduced...
October 13, 2023: BMC Infectious Diseases
https://read.qxmd.com/read/37832871/carbapenem-resistant-escherichia-coli-in-black-headed-gulls-the-danube-and-human-clinical-samples-a-one-health-comparison-of-contemporary-isolates
#38
JOURNAL ARTICLE
József Bálint Nagy, Balázs Koleszár, Bernadett Khayer, Eszter Róka, Levente Laczkó, Erika Ungvári, Eszter Kaszab, Krisztina Bali, Krisztián Bányai, Márta Vargha, Ádám Lovas-Kiss, Ákos Tóth, Gábor Kardos
OBJECTIVES: Our aim was to characterize and compare contemporary carbapenem-resistant Enterobacterales (CRE) isolates from gulls, the River Danube and humans in Hungary, Budapest. METHODS: Multiresistant Enterobacterales were sought for in 227 gull faecal and 24 Danube water samples in 2019-2020. Eosin-methylene blue agar containing 2 mg/l cefotaxime and Colilert-test containing 10 mg/l cefotaxime were used for gull and water samples, respectively. Isolates were characterized by PCRs; acquired carbapenemase producers further analysed by whole genome sequencing, together with 21 Hungarian human CRE...
October 11, 2023: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/37814192/diversity-of-endophytic-fungi-isolated-from-the%C3%A2-bark-of%C3%A2-ceiba-pentandra%C3%A2-l-gaertn-bombacaceae-and-antibacterial-potential-of-secalonic-acid%C3%A2-a-produced-by-diaporthe-searlei-ec-321
#39
JOURNAL ARTICLE
Dominique Sagou, Gilles Alex Pakora, You Christiane Essoh, Dodehe Yeo, Adèle N'douba Kacou
The objective of this study was to study the diversity of endophytic fungi isolated from Ceiba pentandra and to isolate their bioactive chemical compounds. The methodology used during this study consisted in isolating endophytic fungi from the bark of C. pentandra on Potato Agar. The isolates obtained were identified on the basis of the ITS regions of their ribosomal DNA. Antibacterial screening of the mycelium of endophytic fungi isolated  was evaluated against multidrug-resistant E. coli and S...
October 9, 2023: Chemistry & Biodiversity
https://read.qxmd.com/read/37786847/antimicrobial-resistance-of-listeria-monocytogenes-serogroups-iia-and-ivb-from-food-and-food-production-environments-in-poland
#40
JOURNAL ARTICLE
Beata Lachtara, Kinga Wieczorek, Jacek Osek
INTRODUCTION: Listeria monocytogenes is an important foodborne pathogen responsible for human listeriosis, which is a disease with high hospitalisation and mortality rates. The bacteria are usually susceptible to most antibacterial substances, but resistance to some of them has been recently observed. The present study introduces the evidence on the emergence of antibiotic resistance among L. monocytogenes strains isolated from food and food-production environments in Poland. MATERIAL AND METHODS: A total of 283 L...
September 2023: Journal of Veterinary Research
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