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https://www.readbyqxmd.com/read/27908999/draft-genome-sequence-of-a-multiresistant-bovine-isolate-of-staphylococcus-lentus-from-tanzania
#1
Jeremiah Seni, Stephen E Mshana, Felician Msigwa, Mecky Matee, Humphrey Mazigo, Julian Parkhill, Mark A Holmes, Gavin K Paterson
We report here the draft genome sequence of a Staphylococcus lentus isolate, 050AP, collected in Tanzania from a swab of healthy bovine perineum. The draft genome sequence contained 2.72 Mbp and 2,750 coding sequences with a G+C content of 31.7%.
December 1, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27902404/ultrastructural-changes-caused-by-polymyxin-b-and-meropenem-in-multiresistant-klebsiella-pneumoniae-carrying-blakpc-2-gene
#2
Alexsandra Scavuzzi, Luiz Carlos Alves, Dyana Leal Veras, Fábio André Brayner, Ana Catarina de Souza Lopes
The ultrastructural alterations caused by polymyxin B, meropenem and by the association between polymyxin B and meropenem were investigated in 2 multiresistant isolates of K. pneumoniae (K3-A2 and K12-A2) carriers of blaKPC-2, coming from infection and colonization in patients of a public hospital in Recife, Brazil. The ultrastructural changes were detected by transmission electron microscopy and scanning. The susceptibility of the isolates to antimicrobials was tested by the disk diffusion method and microdilution in broth...
October 17, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27896620/antimicrobial-activity-of-topical-agents-against-propionibacterium-acnes-an-in-vitro-study-of-clinical-isolates-from-a-hospital-in-shanghai-china
#3
Ying Ma, Nanxue Zhang, Shi Wu, Haihui Huang, Yanpei Cao
This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute. Susceptibilities to clindamycin and erythromycin were compared in terms of gender, age, disease duration, previous treatment, and disease severity. A total of 69 P. acnes strains were isolated from 98 patients (70...
November 28, 2016: Frontiers of Medicine
https://www.readbyqxmd.com/read/27879666/structural-analysis-of-sortase-a-inhibitors
#4
Georgiana Nitulescu, Anca Zanfirescu, Octavian Tudorel Olaru, Isabela Madalina Nicorescu, George Mihai Nitulescu, Denisa Margina
Bacterial sortases are cysteine transpeptidases that regulate the covalent linkage of several surface protein virulence factors in Gram-positive bacteria. Virulence factors play significant roles in adhesion, invasion of host tissues, biofilm formation and immune evasion, mediating the bacterial pathogenesis and infectivity. Therefore, sortases are emerging as important targets for the design of new anti-infective agents. We employed a computational study, based on structure derived descriptors and molecular fingerprints, in order to develop simple classification methods which could allow predicting low active or high active SrtA inhibitors...
November 22, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27860367/multidrug-resistant-outbreak-associated-salmonella-strains-in-irrigation-water-from-the-metropolitan-region-chile
#5
M C Martínez, P Retamal, J F Rojas-Aedo, J Fernández, A Fernández, L Lapierre
Salmonella enterica (S. enterica) is the main cause of foodborne diseases in the Chilean population. With the aim of characterizing the presence of S. enterica in bodies of water, samples from 40 sources were obtained, including rivers and irrigation canals used by agricultural farms in the most populated regions of Chile. As result, 35 S. enterica isolates belonging to several serotypes were detected, with the highest frequency represented by Typhimurium and Enteritidis. All strains showed phenotypic antimicrobial resistance, and most of them were multiresistant to critically important antimicrobials...
November 12, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27858579/effects-of-methicillin-resistant-staphylococcus-aureus-multiresistant-gram-negative-bacteria-colonization-or-infection-and-isolation-measures-in-end-of-life-on-family-caregivers-results-of-a-qualitative-study
#6
Maria Heckel, Alexander Sturm, Franziska A Herbst, Christoph Ostgathe, Stephanie Stiel
BACKGROUND: Little is known about the experiences of family caregivers of hospitalized patients with confirmed methicillin-resistant Staphylococcus aureus/multiresistant gram-negative bacteria (MRSA/MRGN) diagnosis at the end of life. The study at hand is a subproject of an interdisciplinary cooperation project that aims at developing a patient-, family-, and team-centered approach in dealing with MRSA/MRGN-positive hospitalized patients in palliative and geriatric care. OBJECTIVES: The present study aimed to assess the individual effects of the patient's MRSA/MRGN colonization or infection and isolation measures on family caregivers...
November 18, 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27855770/-epidemic-increase-in-the-incidence-of-carbapenemase-producing-enterobacteriaceae-in-denmark
#7
Mikala Wang, Svend Ellermann-Eriksen, Dennis Schrøder Hansen, Anne Kjerulf, David Fuglsang-Damgaard, Anette Holm, Claus Østergaard, Bent Røder, Ute Wolff Sönksen, Mette Detlefsen, Frank Hansen, Henrik Hasman, Anette Hammerum, Robert L Skov
Carbapenemase-producing Enterobacteriaceae (CPE) are extremely multiresistant bacteria with few or no treatment options. Infections with CPE are associated with a mortality of 40-50%. In Denmark, CPE were first detected in 2008. Prior to 2013 the CPE incidence was low, but since then the incidence has increased significantly. Seven outbreaks have occurred, and at least 25 patients have been infected or colonized. The rise in CPE incidence emphasizes the need for a national intervention to reduce the spread...
November 7, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/27812159/enterobacteriaceae-isolated-from-the-river-danube-antibiotic-resistances-with-a-focus-on-the-presence-of-esbl-and-carbapenemases
#8
Clemens Kittinger, Michaela Lipp, Bettina Folli, Alexander Kirschner, Rita Baumert, Herbert Galler, Andrea J Grisold, Josefa Luxner, Melanie Weissenbacher, Andreas H Farnleitner, Gernot Zarfel
In a clinical setting it seems to be normal these days that a relevant proportion or even the majority of different bacterial species has already one or more acquired antibiotic resistances. Unfortunately, the overuse of antibiotics for livestock breeding and medicine has also altered the wild-type resistance profiles of many bacterial species in different environmental settings. As a matter of fact, getting in contact with resistant bacteria is no longer restricted to hospitals. Beside food and food production, the aquatic environment might also play an important role as reservoir and carrier...
2016: PloS One
https://www.readbyqxmd.com/read/27809263/in-vitro-antimicrobial-activity-of-embothrium-coccineum-used-as-traditional-medicine-in-patagonia-against-multiresistant-bacteria
#9
Nicole Canales, Iván Montenegro, Mario Párraga, Yusser Olguín, Patricio Godoy, Enrique Werner, Alejandro Madrid
Embothrium coccineum J.R. Forst. & G. Forst is an evergreen tree that has been used as a folk remedy for the treatment of neuralgia, tooth pains, wound healing, and glandular conditions, as well as an antiseptic agent against bacterial infection. The antibacterial activities of sequential extracts (hexane, dichloromethane, ethyl acetate, and ethanol) from the leaves of E. coccineum were evaluated by means of the micro-dilution assay against six (Escherichia coli; Klebsiella pneumoniae; Proteus mirabilis; Pseudomonas aeruginosa; Staphylococcus aureus and Streptococcus pyogenes) multiresistant bacteria strains...
October 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27808510/phenanthrenes-from-juncus-inflexus-with-antimicrobial-activity-against-methicillin-resistant-staphylococcus-aureus
#10
Barbara Tóth, Erika Liktor-Busa, Norbert Kúsz, Ádám Szappanos, Attila Mándi, Tibor Kurtán, Edit Urbán, Judit Hohmann, Fang-Rong Chang, Andrea Vasas
The present study has focused on an investigation of the antibacterial effects of Juncus inflexus and the isolation and identification of its active compounds. Eleven phenanthrenes were isolated from a methanolic extract of the roots. Four compounds (jinflexins A-D, 1-4) are new natural products, while seven phenanthrenes [juncuenins A (5), B (6), and D (8), juncusol (7), dehydrojuncuenins A (9) and B (11), and dehydrojuncusol (10)] were isolated for the first time from the plant. Jinflexin D (4) is a dimer with an unprecedented heptacyclic ring system...
November 3, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/27798205/community-carriage-of-esbl-producing-escherichia-coli-is-associated-with-strains-of-low-pathogenicity-a-swedish-nationwide-study
#11
Sofia Ny, Sonja Löfmark, Stefan Börjesson, Stina Englund, Maj Ringman, Jakob Bergström, Pontus Nauclér, Christian G Giske, Sara Byfors
OBJECTIVES: Community carriage of ESBL-producing Escherichia coli (EPE) is common worldwide and there is a need to understand the connection between carriage and infection. We compared the molecular characteristics of EPE among Swedish community carriers with those of EPE causing invasive infections. METHODS: We collected 2134 faecal samples from randomly selected Swedish inhabitants and examined them for the presence of EPE. All participating volunteers answered a questionnaire about putative risk factors for EPE carriage...
October 24, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27775322/inactivation-of-antibiotic-resistant-bacteria-and-resistance-genes-by-ozone-from-laboratory-experiments-to-full-scale-wastewater-treatment
#12
Nadine Czekalski, Stefanie Imminger, Elisabeth Salhi, Marjan Veljkovic, Karolin Kleffel, David Drissner, Frederik Hammes, Helmut Bürgmann, Urs von Gunten
Ozone, a strong oxidant and disinfectant, seems ideal to cope with future challenges of water treatment, such as micropollutants, multiresistant bacteria (MRB) and even intracellular antibiotic resistance genes (ARG), but information on the latter is scarce. In ozonation experiments we simultaneously determined kinetics and dose-dependent inactivation of Escherichia coli and its plasmid-encoded sulfonamide resistance gene sul1 in different water matrixes. Effects in E. coli were compared to an autochthonous wastewater community...
November 1, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27768822/genomics-and-the-evolution-of-antibiotic-resistance
#13
Michael R Gillings, Ian T Paulsen, Sasha G Tetu
Antibiotic resistance arises as a consequence of complex interactions among genes, mobile elements, and their bacterial hosts, coupled with the intense selection pressures imposed by humans in an attempt to control bacterial growth. Understanding the evolution of resistance requires an understanding of interacting cellular and genetic components. Here, we review how DNA analysis has helped reconstruct the origins of the mosaic, multiresistant mobile elements that have spread through pathogens in the last 60 years...
October 21, 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27762078/phenotypic-resistance-to-disinfectants-and-antibiotics-in-methicillin-resistant-staphylococcus-aureus-strains-isolated-from-pigs
#14
E Espigares, E Moreno Roldan, M Espigares, R Abreu, B Castro, A L Dib, Á Arias
The aim of this research was to study the phenotypic resistances to disinfectants and antibiotics in strains of methicillin-resistant Staphylococcus aureus (MRSA) obtained from Canary black pigs. Analyses were performed on 54 strains of MRSA, isolated in Canary black pigs from the province of Tenerife (Spain); all of them carried the mecA gene. The strains were isolated by means of nasal swab samples of healthy pigs, collected under veterinarian supervision. Bactericidal activity of antiseptics and disinfectants was tested by means of the dilution-neutralization method...
October 20, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27760017/phenotypical-and-genotypical-antimicrobial-resistance-of-coagulase-negative-staphylococci-isolated-from-cow-mastitis
#15
I Klimiene, M Virgailis, A Pavilonis, R Siugzdiniene, R Mockeliunas, M Ruzauskas
The objectives of this study were to determine the prevalence and antimicrobial resistance of coagulase-negative staphylococci (CNS) isolated from dairy cows with subclinical mastitis. Antimicrobial resistance in staphylococci were evaluated by breakpoint values specific to the species (EU-CAST). The presence of resistance-encoding genes was detected by multiplex PCR. A total of 191 CNS isolates were obtained. The CNS isolates were typically resistant to penicillin (67.4%), tetracyc-line (18.9%), and erythromycin (13...
September 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27737557/structure-function-profile-of-mmpl3-the-essential-mycolic-acid-transporter-from-mycobacterium-tuberculosis
#16
Juan Manuel Belardinelli, Amira Yazidi, Liang Yang, Lucien Fabre, Wei Li, Benoit Jacques, Shiva Kumar Angala, Isabelle Rouiller, Helen I Zgurskaya, Jurgen Sygusch, Mary Jackson
The MmpL family of proteins translocates complex (glyco)lipids and siderophores across the cell envelope of mycobacteria and closely related Corynebacteriaceae and plays important roles in the biogenesis of the outer membrane of these organisms. Despite their significance in the physiology and virulence of Mycobacterium tuberculosis, and from the perspective of developing novel antituberculosis agents, little is known about their structure and mechanism of translocation. In this study, the essential mycobacterial mycolic acid transporter, MmpL3, and its orthologue in Corynebacterium glutamicum, CmpL1, were investigated as prototypical MmpL proteins to gain insight into the transmembrane topology, tertiary and quaternary structures, and functional regions of this transporter family...
October 14, 2016: ACS Infectious Diseases
https://www.readbyqxmd.com/read/27736767/updated-multiplex-pcr-for-detection-of-all-six-plasmid-mediated-qnr-gene-families
#17
Gabriela Bergiante Kraychete, Larissa Alvarenga Batista Botelho, Eloiza Helena Campana, Renata Cristina Picão, Raquel Regina Bonelli
Plasmid-mediated qnr genes have been reported in bacteria worldwide, widely associated to other relevant determinants of resistance in multiresistance plasmids. Here, we provide an update on a previously described multiplex PCR, in order to detect all six qnr families (including qnrA, qnrS, qnrB, qnrC, qnrD and qnrVC) described until now. The proposed method makes possible the screening of these genes reducing cost and time, and may demonstrate an underestimated prevalence of the latest variants described.
October 10, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27734638/pattern-of-urinary-antibiograms-in-a-tertiary-care-hospital-of-eastern-india
#18
Nandini Chatterjee, Chandan Chatterjee, Sinjan Ghosh, Mainak Mukhopadhyay, Ramkrishna Brahmachari, Kartik Patar
BACKGROUND: Indiscriminate use of antibiotics in urinary tract infections have led to emergence of 'superbugs' worldwide. Periodical review of antibiograms is of utmost importance for optimum patient benefit. OBJECTIVE: To identify the spectrum of organisms responsible for urinary tract infection and evaluate the pattern of antibiotic sensitivity of the organisms. METHODS: Urine samples were collected from all consecutive patients getting admitted in the medicine indoor irrespective of symptomatology...
April 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27723383/antimicrobial-resistance-of-salmonella-serovars-and-campylobacter-spp-isolated-from-an-opportunistic-gull-species-yellow-legged-gull-larus-michahellis
#19
Lourdes Migura-Garcia, Raül Ramos, Marta Cerdà-Cuéllar
Wildlife is a natural reservoir of Salmonella and Campylobacter, the most important human foodborne pathogens worldwide. Free-living birds have the potential to transport, over large distances, such zoonotic bacteria that may harbor antimicrobial resistance traits. On the northeastern Iberian coast, we assessed the role of Yellow-legged Gulls ( Larus michahellis ) as reservoirs of antimicrobial resistance in Salmonella and thermophilic Campylobacter isolates recovered from gulls at three colonies, with varying degrees of dependence on refuse dumps as food sources...
October 10, 2016: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/27712972/pyogenic-liver-abscess-current-status-and-predictive-factors-for-recurrence-and-mortality-of-first-episodes
#20
Matías E Czerwonko, Pablo Huespe, Santiago Bertone, Pablo Pellegrini, Oscar Mazza, Juan Pekolj, Eduardo de Santibañes, Sung Ho Hyon, Martín de Santibañes
BACKGROUND: In times of modern surgery, transplantation and percutaneous techniques, pyogenic liver abscess (PLA) has essentially become a problem of biliary or iatrogenic origin. In the current scenario, diagnostic approach, clinical behavior and therapeutic outcomes have not been profoundly studied. This study analyzes the clinical and microbiological features, diagnostic methods, therapeutic management and predictive factors for recurrence and mortality of first episodes of PLA. METHODS: A retrospective single-center study was conducted including 142 patients admitted to the Hospital Italiano de Buenos Aires, between 2005 and 2015 with first episodes of PLA...
October 3, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
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