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https://www.readbyqxmd.com/read/29149329/polymyxin-derivatives-nab739-and-nab815-are-more-effective-than-polymyxin-b-in-murine-escherichia-coli-pyelonephritis
#1
Martti Vaara, Timo Vaara, Carina Vingsbo Lundberg
Objectives: Extremely multiresistant strains of Enterobacteriaceae, such as those of Escherichia coli and Klebsiella pneumoniae, are emerging and spreading at a worrisome speed. Polymyxins (polymyxin B, colistin) are used as last-line therapy against such strains, in spite of their notable nephrotoxicity that may even require discontinuation of the therapy. We have previously developed polymyxin derivatives NAB739 and NAB815 that are better tolerated in cynomolgus monkeys than polymyxin B and are, in contrast to polymyxin B, excreted in the cynomolgus urine to a very significant degree...
November 14, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29132828/lactoferrin-chitosan-and-melaleuca-alternifolia-natural-products-that-show-promise-in-candidiasis-treatment
#2
REVIEW
Lorena de Oliveira Felipe, Willer Ferreira da Silva Júnior, Katialaine Corrêa de Araújo, Daniela Leite Fabrino
The evolution of microorganisms resistant to many medicines has become a major challenge for the scientific community around the world. Motivated by the gravity of such a situation, the World Health Organization released a report in 2014 with the aim of providing updated information on this critical scenario. Among the most worrying microorganisms, species from the genus Candida have exhibited a high rate of resistance to antifungal drugs. Therefore, the objective of this review is to show that the use of natural products (extracts or isolated biomolecules), along with conventional antifungal therapy, can be a very promising strategy to overcome microbial multiresistance...
November 10, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29107747/vanillin-selectively-modulates-the-action-of-antibiotics-against-resistant-bacteria
#3
Camila Fonseca Bezerra, Cicera Janaine Camilo, Maria Karollyna do Nascimento Silva, Thiago Sampaio de Freitas, Jaime Ribeiro-Filho, Henrique Douglas Melo Coutinho
The treatment of infections caused by microorganisms that are resistant to antibiotics represent one of the main challenges of medicine today, especially due to the inefficacy of long-term drug therapy. In the search for new alternatives to treat these infections, many researchers have been looking for new substances derived from natural products to replace, or be used in combination with conventional antibiotics. Vanillin is a phenolic compound whose antimicrobial activity has been used in the elimination of pathogens present in fruits and vegetables...
October 28, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29106651/target-pathogen-a-structural-bioinformatic-approach-to-prioritize-drug-targets-in-pathogens
#4
Ezequiel J Sosa, Germán Burguener, Esteban Lanzarotti, Lucas Defelipe, Leandro Radusky, Agustín M Pardo, Marcelo Marti, Adrián G Turjanski, Darío Fernández Do Porto
Available genomic data for pathogens has created new opportunities for drug discovery and development to fight them, including new resistant and multiresistant strains. In particular structural data must be integrated with both, gene information and experimental results. In this sense, there is a lack of an online resource that allows genome wide-based data consolidation from diverse sources together with thorough bioinformatic analysis that allows easy filtering and scoring for fast target selection for drug discovery...
November 2, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29105983/radical-copolymerization-of-vinyl-ethers-and-cyclic-ketene-acetals-as-a-versatile-platform-to-design-functional-polyesters
#5
Antoine Tardy, Jean-Claude Honoré, Johanna Tran, Didier Siri, Vianney Delplace, Isabelle Bataille, Didier Letourneur, Josette Perrier, Cendrine Nicoletti, Marc Maresca, Catherine Lefay, Didier Gigmes, Julien Nicolas, Yohann Guillaneuf
For the first time, the free-radical copolymerization of cyclic ketene acetals (CKAs) and vinyl ethers (VEs) was investigated as an efficient, yet simple approach for the preparation of functional aliphatic polyesters. The copolymerization of CKA and VE was first predicted to be quasi-ideal by DFT calculations. The theoretical prediction was experimentally confirmed by the copolymerization of 2-methylene-1,3-dioxepane (MDO) and butyl vinyl ether (BVE), leading to rMDO = 0.73 and rBVE = 1.61. We then illustrated the versatility of this approach by preparing different functional polyesters: (i) copolymers functionalized by fluorescent probes; (ii) amphiphilic copolymers grafted with poly(ethylene glycol) (PEG) side chains able to self-assemble into PEGylated nanoparticles; (iii) antibacterial films active against Gram+ and Gram- bacteria (including a multiresistant strain) and (iv) cross-linked bioelastomers with suitable properties for tissue engineering applications...
November 5, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29094477/rescue-therapy-with-bismuth-quadruple-regimen-in-patients-with-helicobacter-pylori-resistant-strains
#6
Giulia Fiorini, Ilaria Maria Saracino, Angelo Zullo, Luigi Gatta, Matteo Pavoni, Dino Vaira
BACKGROUND: Bismuth quadruple therapy (BQT) is the recommended rescue therapy for Helicobacter pylori (H. pylori) infection. This study aimed to assess the efficacy and safety of a 10-day BQT regimen in patients who failed previous therapies and were infected with multiresistant H. pylori strains MATERIALS AND METHODS: Helicobacter pylori-infected patients underwent endoscopy, culture, and susceptibility test for clarithromycin, metronidazole, and levofloxacin. Treatment with three-in-one capsule (Pylera®) four times daily and esomeprazole 20 mg twice daily for 10 days was administered...
November 1, 2017: Helicobacter
https://www.readbyqxmd.com/read/29091185/genomic-sequences-of-streptococcus-agalactiae-with-high-level-gentamicin-resistance-collected-in-the-bsac-bacteraemia-surveillance
#7
Michel Doumith, Shazad Mushtaq, Veronique Martin, Aiysha Chaudhry, Rachael Adkin, Juliana Coelho, Vicki Chalker, Alasdair MacGowan, Neil Woodford, David M Livermore
Background: Like other streptococci, Streptococcus agalactiae typically has intrinsic low-level aminoglycoside resistance. High-level gentamicin resistance was seen in 2 of 1125 isolates collected in the BSAC Bacteraemia Surveillance Programme between 2001 and 2014. These organisms, both isolated in 2014, were characterized. Methods: Identifications were by latex agglutination, MICs by BSAC agar dilution and sequencing by Illumina methodology. Results: Gentamicin MICs were >1024 mg/L versus a species mode of 8 mg/L; both isolates also were unusually ciprofloxacin resistant with MICs of 64 mg/L versus a species mode of 1 mg/L...
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29090643/identification-through-maldi-tof-mass-spectrometry-and-antimicrobial-susceptibility-profiling-of-bacterial-pathogens-isolated-from-sow-urinary-tract-infection
#8
Luisa Z Moreno, Carlos E C Matajira, Andre P Poor, Renan E Mesquita, Vasco T M Gomes, Ana Paula S Silva, Cristina R Amigo, Ana Paula G Christ, Mikaela R F Barbosa, Maria Inês Z Sato, Andrea M Moreno
BACKGROUND: Urinary tract infection (UTI) is a common disease in sows due to intensification of pig production. Despite direct economic losses, UTI prevalence and respective microbial identification are still poorly studied. OBJECTIVE: The aims of this study were to identify the causative agents of UTI in sows through MALDI-TOF mass spectrometry and to characterize their respective antimicrobial resistance profiles. MATERIALS AND METHODS: Urine samples from 300 sows of three swine herds from São Paulo State (Brazil) were screened for UTI; suggestive samples were submitted to bacterial isolation...
November 1, 2017: Veterinary Quarterly
https://www.readbyqxmd.com/read/29059308/potential-of-high-dose-cefepime-tazobactam-against-multiresistant-gram-negative-pathogens
#9
David M Livermore, Shazad Mushtaq, Marina Warner, Simon J Turner, Neil Woodford
Background: Early β-lactamase inhibitors were combined with established penicillins, but different combinations may be more appropriate to counter current β-lactamase threats, with development facilitated by the US Generating Antibiotic Incentives Now (GAIN) Act. Cefepime/tazobactam is especially attractive, combining an AmpC-stable cephalosporin with a clinically established inhibitor, active against ESBLs and suitable for high-dose administration. Methods: Organisms (n = 563) were clinical isolates submitted to the UK national reference laboratory...
October 20, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29057595/aseptic-surgical-preparation-for-upper-eyelid-blepharoplasty-via-full-face-octenidine-antiseptic-without-antibiotic-medication-shows-effective-prophylaxis-against-post-surgical-wound-infection
#10
Johannes Matiasek, Philip Kienzl, Gerlinde R Otti, Bela R Turk, Gabriel Djedovic, Ulrich M Rieger
Blepharoplasty is the third most common plastic surgical procedure in the USA. Due to the emergence of multiresistant bacteria, optimising the antiseptic procedure is crucial. Choice of antiseptics plays an important role as they may cause skin irritation and colouring of disinfected areas. In this study, the use of the aqueous antiseptic octenisept® (octenidine) was evaluated in the outcome of blepharoplasties: incidence of wound dehiscence; haematoma; and infection in correlation with gender, medication, smoking habits and time of year...
October 23, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29051260/draft-genome-sequence-of-a-community-acquired-methicillin-resistant-staphylococcus-aureus-usa300-isolate-from-a-river-sample
#11
Sarah Lepuschitz, Robert Mach, Burkhard Springer, Franz Allerberger, Werner Ruppitsch
The increasing emergence of multiresistant bacteria in health care settings in the community and in the environment represents a major health threat worldwide. Here, we report the draft genome sequence of a community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) USA300 isolate (W1) from a small river in southern Austria.
October 19, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29048473/use-of-taurolidine-in-lung-transplantation-for-cystic-fibrosis-and-impact-on-bacterial-colonization
#12
Mohamed Zeriouh, Anton Sabashnikov, Nikhil P Patil, Bastian Schmack, Barlomiej Zych, Prashant N Mohite, Diana García Sáez, Achim Koch, Ashham Mansur, Simona Soresi, Alexander Weymann, Nandor Marczin, Thorsten Wahlers, Fabio De Robertis, André Rüdiger Simon, Aron-Frederik Popov
OBJECTIVES: The presence of bacterial colonization that causes chronic pulmonary infections in cystic fibrosis (CF) patients remains a key issue before lung transplantation. We sought to assess the impact of intraoperative taurolidine lavage on bacterial colonization and long-term outcomes following lung transplantation in CF patients. METHODS: Between 2007 and 2013, 114 CF patients underwent lung transplantation at our institute, and taurolidine 2% bronchial lavage was applied in a substantial proportion of patients (n = 42)...
October 18, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29044831/a-cluster-of-scedosporiosis-in-lung-transplant-candidates-and-recipients-the-zurich-experience-and-review-of-the-literature
#13
Irene A Abela, Christian Murer, Macé M Schuurmans, Juergen W Schmitt, Frabci Muller, Frank Imkamp, Nicolas J Mueller, Christian Benden
Scedosporium species are fungal pathogens increasingly recognized in cystic fibrosis (CF). They can cause multiresistant, life-threatening infections that are of particular concern in CF patients undergoing lung transplantation, as optimal treatment remains unclear. Here, we describe our Zurich experience of CF patients with Scedosporium infection. Disseminated infection occurred in one patient after transplantation and was successfully treated. We propose a step-by-step approach to treat candidates with colonization, and discuss our cases in the context of the current literature...
October 17, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29039707/first-detection-of-ctx-m-1-in-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-in-seafood-from-tunisia
#14
Leila Ben Said, Mouna Hamdaoui, Ahlem Jouini, Abdellatif Boudabous, Karim Ben Slama, Carmen Torres, Naouel Klibi
The purpose of this study was to determine the carriage rate of Escherichia coli isolates in seafood, to analyze the phenotype and genotype of antimicrobial resistance in the recovered isolates, and to characterize extended-spectrum β-lactamase (ESBL) E. coli producers. E. coli isolates were recovered from 24 (34.3%) of the 70 seafood samples analyzed, and one isolate per sample was further characterized. Antibiotic resistance was determined by the disk diffusion method in the 24 isolates, with the following results (number of resistant isolates): tetracycline (8), streptomycin (7), ampicillin (6), trimethoprim-sulfamethoxazole (4), chloramphenicol (4), ciprofloxacin (3), cefotaxime (2), and ceftazidime (2)...
October 17, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29038902/-urinary-tract-infections-what-has-been-confirmed-in-therapy
#15
REVIEW
J Marcon, C G Stief, G Magistro
Urinary tract infections (UTIs) affect approximately 150 million people worldwide per year, causing annual health costs of over three billion dollars just in the USA. Every second woman experiences at least one UTI in her lifetime, with every one in four experiencing recurrence. Uncomplicated infections like single or recurrent cystitis and pyelonephritis can be distinguished from complicated disease. UTIs in men can spread to the male glands, causing prostatitis and epididymitis. Antibiotic therapy is the standard procedure for UTIs...
October 16, 2017: Der Internist
https://www.readbyqxmd.com/read/29037960/effect-of-procalcitonin-guided-antibiotic-treatment-on-mortality-in-acute-respiratory-infections-a-patient-level-meta-analysis
#16
Philipp Schuetz, Yannick Wirz, Ramon Sager, Mirjam Christ-Crain, Daiana Stolz, Michael Tamm, Lila Bouadma, Charles E Luyt, Michel Wolff, Jean Chastre, Florence Tubach, Kristina B Kristoffersen, Olaf Burkhardt, Tobias Welte, Stefan Schroeder, Vandack Nobre, Long Wei, Heiner C Bucher, Djillali Annane, Konrad Reinhart, Ann R Falsey, Angela Branche, Pierre Damas, Maarten Nijsten, Dylan W de Lange, Rodrigo O Deliberato, Carolina F Oliveira, Vera Maravić-Stojković, Alessia Verduri, Bianca Beghé, Bin Cao, Yahya Shehabi, Jens-Ulrik S Jensen, Caspar Corti, Jos A H van Oers, Albertus Beishuizen, Armand R J Girbes, Evelien de Jong, Matthias Briel, Beat Mueller
BACKGROUND: In February, 2017, the US Food and Drug Administration approved the blood infection marker procalcitonin for guiding antibiotic therapy in patients with acute respiratory infections. This meta-analysis of patient data from 26 randomised controlled trials was designed to assess safety of procalcitonin-guided treatment in patients with acute respiratory infections from different clinical settings. METHODS: Based on a prespecified Cochrane protocol, we did a systematic literature search on the Cochrane Central Register of Controlled Trials, MEDLINE, and Embase, and pooled individual patient data from trials in which patients with respiratory infections were randomly assigned to receive antibiotics based on procalcitonin concentrations (procalcitonin-guided group) or control...
October 13, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29033915/evaluation-of-the-swabbing-of-disposable-absorbent-incontinence-products-for-assessing-the-carriage-of-multiresistant-enterobacteriaceae-in-nursing-home-residents
#17
Alexis Naf, Marie Decalonne, Sandra Dos Santos, Laurent Mereghetti, Nathalie L van der Mee-Marquet
We compared the performance of incontinence product (IP) and rectal swabbing for the detection of multidrug-resistant Enterobacteriaceae (MDRE) carriage in a large multicenter study conducted in February 2017 among the residents of 23 French nursing homes. The study included 547 residents who habitually wore IP, 88 of whom were MDRE carriers (16.1%). Positive results were obtained for both rectal and IP swabs for 64 of these residents, for rectal swabs only for 22 and for IP swabs only for two of these patients...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29031065/synthesis-and-antibacterial-activity-of-new-symmetric-polyoxygenated-dibenzofurans
#18
Sandra Oramas-Royo, Kriss Dayana Pantoja, Ángel Amesty, Carmen Romero, Isabel Lorenzo-Castrillejo, Félix Machín, Ana Estévez-Braun
A series of symmetric polyoxygenated dibenzofurans with 2-methylbutyril moieties at C-4 and C-6 were obtained from commercial phloroglucinol through a sequence of reactions that include monoacylation, iodination, Suzuki-Miyaura coupling, oxidative dimerization and cyclization. Some of the compounds obtained were active against Gram-positive bacteria, including multiresistant Staphylococcus aureus clinical isolates. The dibenzofuran 28 with propyl chains at C-2 and C-8 exhibited the best antibacterial activity with values comparable to those of the natural dibenzofuran achyrofuran...
December 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29024753/spread-of-multidrug-resistant-high-risk-klebsiella-pneumoniae-clones-in-a-tertiary-hospital-from-southern-brazil
#19
Guilherme Bartolomeu Gonçalves, João Pedro Rueda Furlan, Eliana Carolina Vespero, Marsileni Pelisson, Eliana Guedes Stehling, André Pitondo-Silva
Klebsiella pneumoniae is among the most important pathogens found in hospitals. The emergence of multiple antibiotic resistant K. pneumoniae associated with its virulence factors is a worldwide concern and its early identification is crucial, especially for controlling the spread of emerging clones. This article reports a high prevalence of multiresistant K. pneumoniae in a university hospital in southern Brazil, harboring several virulence and β-lactamase encoding genes, including pandrug-resistant high-risk international clones belonging to the clonal group 258 (ST11, ST15, ST101, ST258, ST340 and ST874)...
October 10, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28961986/novel-multiresistance-cfr-plasmids-in-linezolid-resistant-methicillin-resistant-staphylococcus-epidermidis-and-vancomycin-resistant-enterococcus-faecium-vre-from-a-hospital-outbreak-co-location-of-cfr-and-optra-in-vre
#20
Alexandros Lazaris, David C Coleman, Angela M Kearns, Bruno Pichon, Peter M Kinnevey, Megan R Earls, Breida Boyle, Brian O'Connell, Gráinne I Brennan, Anna C Shore
Background: Linezolid is often the drug of last resort to treat infections caused by Gram-positive cocci. Linezolid resistance can be mutational (23S rRNA or L-protein) or, less commonly, acquired [predominantly cfr , conferring resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins and streptogramin A compounds (PhLOPS A ) or optrA , encoding oxazolidinone and phenicol resistance]. Objectives: To investigate the clonality and genetic basis of linezolid resistance in 13 linezolid-resistant (LZDR) methicillin-resistant Staphylococcus epidermidis (MRSE) isolates recovered during a 2013/14 outbreak in an ICU in an Irish hospital and an LZDR vancomycin-resistant Enterococcus faecium (VRE) isolate from an LZDR-MRSE-positive patient...
August 28, 2017: Journal of Antimicrobial Chemotherapy
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