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https://www.readbyqxmd.com/read/28806973/protective-effects-of-orange-citrus-sinensis-l-peel-aqueous-extract-and-hesperidin-on-oxidative-stress-and-peptic-ulcer-induced-by-alcohol-in-rat
#1
Slimen Selmi, Kais Rtibi, Dhekra Grami, Hichem Sebai, Lamjed Marzouki
BACKGROUND: Massive alcohol drinking can lead to gastric ulcer. In the present study we investigated the gastroprotective effect of Citrus sinensis peel aqueous extract (CSPE) and Hesperidin (H) in ethanol (EtOH) induced oxidative stress and peptic ulcer in rats. METHODS: Seventy adult male Wistar rats were divided into seven groups of 10 each: control, EtOH (4 g/kg b.w.), EtOH + various doses of CSPE (100, 200 and 400 mg/kg, b.w.), EtOH + Hesperidin (50 mg/kg, p...
August 14, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28802231/phytochemical-properties-and-pharmacological-effects-of-quercus-ilex-l-aqueous-extract-on-gastrointestinal-physiological-parameters-in-vitro-and-in-vivo
#2
Kaïs Rtibi, Imen Hammami, Slimen Selmi, Dhekra Grami, Hichem Sebai, Mohamed Amri, Lamjed Marzouki
INTRODUCTION: Several research studies have reported on the pharmacological relevance of the medicinal plants used for treating various gastrointestinal disorders and controlling the dietary glucose uptake in the intestinal tract. METHODS: Male rats were used to investigate the pharmacological effects of green oak acorn aqueous extract (GOAE) on gastrointestinal physiological parameters in vivo and in vitro. In this respect, the gastro-intestinal motility and hypersecretion essays were evaluated using a simple test meal (10% charcoal in 5% gum arabic) and castor oil induced diarrhea...
August 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28801072/irinotecan-chemotherapy-induced-intestinal-oxidative-stress-underlying-causes-of-disturbed-mucosal-water-and-electrolyte-transport
#3
Kaïs Rtibi, Slimen Selmi, Dhekra Grami, Hichem Sebai, Mohamed Amri, Lamjed Marzouki
Irinotecan, a chemotherapy drug, can cause acute diarrhea immediately after administration. Hence, the present study was designed to investigate the gastrointestinal (GI) disturbances after an intraperitoneal (IP) administration of irinotecan in rats.Twenty Wistar rats were separated into two groups of ten. Group A was considered as a control group (NaCl, 0.9%). Group B was treated with irinotecan at a single dose of 200mgkg(-1). The rats were observed for defecation. For the enteropooling test, the animals were sacrificed by decapitation 1h post-treatment...
July 23, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28711559/outbreak-of-colistin-resistant-carbapenemase-producing-klebsiella-pneumoniae-in-tunisia
#4
Wejdène Mansour, Marisa Haenni, Estelle Saras, Raoudha Grami, Yosra Mani, Anis Ben Haj Khalifa, Souhail El Atrouss, Mohamed Kheder, Mohamed Fekih Hassen, Noureddine Boujâafar, Olfa Bouallegue, Jean-Yves Madec
OBJECTIVES: Mechanisms of colistin and carbapenem resistance among a collection of Klebsiella pneumoniae isolates recovered in a university hospital in Tunisia were studied. METHODS: In vitro antimicrobial susceptibility testing, S1 nuclease pulsed-field gel electrophoresis (S1-PFGE), Southern blotting and PCR-based replicon typing (PBRT) were performed. Extended-spectrum β-lactamases (ESBLs), carbapenemases, AmpC-type enzymes and mgrB genes were detected by PCR and sequencing...
July 12, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28686965/chemical-constituents-and-pharmacological-actions-of-carob-pods-and-leaves-ceratonia-siliqua-l-on-the-gastrointestinal-tract-a-review
#5
REVIEW
Kaïs Rtibi, Slimen Selmi, Dhekra Grami, Mohamed Amri, Bruno Eto, Jamel El-Benna, Hichem Sebai, Lamjed Marzouki
Carob tree, Ceratonia siliqua L., is a medicinal plant used in Tunisian traditional medicine for the treatment of the gastro-intestinal (GI) disorders. In this respect, a relatively large number of scientific publications on the carob tree have been published in recent years. Therefore, the present review was aimed to analyze the traditional uses, phytochemical constituents and pharmacological activities of Ceratonia siliqua on the GI tract. Indeed, previous investigations on the carob pods and leaves have revealed the presence of a number of compounds including high amounts of carbohydrates, dietary fibers, minerals, polyphenols, flavonoids and low amounts of protein and lipids...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28648624/extended-spectrum-%C3%AE-lactamases-and-plasmid-mediated-quinolone-resistance-in-enterobacterial-clinical-isolates-from-neonates-in-tunisia
#6
Karama Charfi, Raoudha Grami, Abir Ben Jeddou, Aziza Messaoudi, Yosra Mani, Olfa Bouallegue, Noureddine Boujaafar, Mahjoub Aouni, Hedi Mammeri, Wejdène Mansour
This study was conducted to investigate extended-spectrum-β-lactamase (ESBL) producing Enterobacteriaceae isolates from the Center of Maternity and Neonatology of Monastir, Tunisia. Fourty-six strains out of 283 were found to produce ESBL: Klebsiella pneumoniae (n = 37), Escherichia coli (n = 6), Enterobacter cloacae (n = 2), and Citrobacter freundi (n = 1). Genotyping analysis, using ERIC2 and RAPD, showed that strains were clonally unrelated. PCR amplification followed by sequencing revealed that all strains produced CTX-M-15...
June 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28226332/responsible-safe-and-effective-prescription-of-opioids-for-chronic-non-cancer-pain-american-society-of-interventional-pain-physicians-asipp-guidelines
#7
Laxmaiah Manchikanti, Adam M Kaye, Nebojsa Nick Knezevic, Heath McAnally, Konstantin Slavin, Andrea M Trescot, Susan Blank, Vidyasagar Pampati, Salahadin Abdi, Jay S Grider, Alan D Kaye, Kavita N Manchikanti, Harold Cordner, Christopher G Gharibo, Michael E Harned, Sheri L Albers, Sairam Atluri, Steve M Aydin, Sanjay Bakshi, Robert L Barkin, Ramsin M Benyamin, Mark V Boswell, Ricardo M Buenaventura, Aaron K Calodney, David L Cedeno, Sukdeb Datta, Timothy R Deer, Bert Fellows, Vincent Galan, Vahid Grami, Hans Hansen, Standiford Helm Ii, Rafael Justiz, Dhanalakshmi Koyyalagunta, Yogesh Malla, Annu Navani, Kent H Nouri, Ramarao Pasupuleti, Nalini Sehgal, Sanford M Silverman, Thomas T Simopoulos, Vijay Singh, Daneshvari R Solanki, Peter S Staats, Ricardo Vallejo, Bradley W Wargo, Arthur Watanabe, Joshua A Hirsch
BACKGROUND: Opioid use, abuse, and adverse consequences, including death, have escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse, numerous regulations and guidelines for responsible opioid prescribing have been developed by various organizations. However, the US opioid epidemic is continuing and drug dose deaths tripled during 1999 to 2015. Recent data show a continuing increase in deaths due to natural and semisynthetic opioids, a decline in methadone deaths, and an explosive increase in the rates of deaths involving other opioids, specifically heroin and illicit synthetic fentanyl...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/27965224/feasibility-and-effectiveness-of-a-delirium-prevention-bundle-in-critically-ill-patients
#8
Claudia DiSabatino Smith, Petra Grami
BACKGROUND: Strategies for preventing delirium include early identification and avoiding or modifying patient, environmental, and iatrogenic factors. Minimal research exists on a prescriptive delirium prevention bundle that details elements or strategies for each bundle component. Even less research has been focused on nurse-driven interventions or components. OBJECTIVE: To evaluate the effectiveness of a delirium prevention bundle in decreasing delirium incidence in 2 medical-surgical intensive care units in a large Texas medical center...
December 2016: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/27850888/1252-an-innovative-approach-using-an-exercise-physiologist-in-the-critical-care-setting-for-mobilization
#9
Petra Grami, Claudia Smith, Cheryl Haseeb, Dereddi Raja Reddy, Donal Palencia
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27739095/ceratonia-siliqua-l-immature-carob-bean-inhibits-intestinal-glucose-absorption-improves-glucose-tolerance-and-protects-against-alloxan-induced-diabetes-in-rat
#10
Kaïs Rtibi, Slimen Selmi, Dhekra Grami, Khouloud Saidani, Hichem Sebai, Mohamed Amri, Bruno Eto, Lamjed Marzouki
BACKGROUND: This study was designed to investigate the effects of immature carob pod aqueous extract (ICPAE) on intestinal glucose absorption in vitro and in vivo using an oral glucose tolerance test (OGTT) as well as the potential antidiabetic effect in alloxan-induced diabetic rats. OGTT was carried by administration of glucose (2 g kg(-1) , p.o.) and after treatment with extract (50, 100 and 200 mg kg(-1) body weight). Diabetes was induced by single intraperitoneal injection of alloxan (150 mg kg(-1) )...
October 14, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27125201/production-and-identification-of-iturin-a-lipopeptide-from-bacillus-methyltrophicus-teb1-for-control-of-phoma-tracheiphila
#11
Leila Kalai-Grami, Ines Karkouch, Omar Naili, Imen Ben Slimene, Salem Elkahoui, Roudaina Ben Zekri, Ines Touati, Monia Mnari-Hattab, Mohamed Rabeh Hajlaoui, Ferid Limam
A lipopeptide-producing endophytic Bacillus methyltrophicus TEB1 strain exhibited potent antifungal activity against Phoma tracheiphila. Lipopeptide production started at the early growth phase plateaued after 36 h of culture where it reduced the mycelium growth by 80%. The crude lipopeptide extract harvested at the stationary phase efficiently inhibited the growth of P. tracheiphila mycelium and MIC values displaying 50 and 90% inhibition of conidia germination were around 47.5 and 100 μg ml(-1) , respectively...
August 2016: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/26940999/impact-of-food-animal-trade-on-the-spread-of-mcr-1-mediated-colistin-resistance-tunisia-july-2015
#12
Raoudha Grami, Wejdene Mansour, Wahib Mehri, Olfa Bouallègue, Noureddine Boujaâfar, Jean-Yves Madec, Marisa Haenni
We report a high prevalence of MCR-1 and CTX-M-1-producing Escherichia coli in three Tunisian chicken farms. Chickens were imported from France or derived from French imported chicks. The same IncHI2-type plasmid reported to carry those genes in cattle in France and in a food sample in Portugal was found in Tunisian chickens of French origin. This suggests a significant impact of food animal trade on the spread of mcr-1-mediated colistin resistance in Europe.
2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/26606031/efficacy-of-epidural-injections-in-managing-chronic-spinal-pain-a-best-evidence-synthesis
#13
REVIEW
Alan D Kaye, Laxmaiah Manchikanti, Salahadin Abdi, Sairam Atluri, Sanjay Bakshi, Ramsin Benyamin, Mark V Boswell, Ricardo Buenaventura, Kenneth D Candido, Harold J Cordner, Sukdeb Datta, Gulshan Doulatram, Christopher G Gharibo, Vahid Grami, Sanjeeva Gupta, Sachin Jha, Eugene D Kaplan, Yogesh Malla, Dharam P Mann, Devi E Nampiaparampil, Gabor Racz, Prithvi Raj, Maunak V Rana, Manohar Lal Sharma, Vijay Singh, Amol Soin, Peter S Staats, Ricardo Vallejo, Bradley W Wargo, Joshua A Hirsch
BACKGROUND: Epidural injections have been used since 1901 in managing low back pain and sciatica. Spinal pain, disability, health, and economic impact continue to increase, despite numerous modalities of interventions available in managing chronic spinal pain. Thus far, systematic reviews performed to assess the efficacy of epidural injections in managing chronic spinal pain have yielded conflicting results. OBJECTIVE: To evaluate and update the clinical utility of the efficacy of epidural injections in managing chronic spinal pain...
November 2015: Pain Physician
https://www.readbyqxmd.com/read/26570722/1061-impact-of-order-set-utilization-for-the-treatment-of-patients-with-severe-sepsis-and-septic-shock
#14
Chiamaka Ike, Puneet Freibott, Karen Myers, John Sabo, Lucretia Davis, Linda Cole, Petra Grami, Greg Laine
No abstract text is available yet for this article.
December 2015: Critical Care Medicine
https://www.readbyqxmd.com/read/26447939/emergence-of-st147-klebsiella-pneumoniae-producing-oxa-204-carbapenemase-in-a-university-hospital-tunisia
#15
Raoudha Grami, Wejdene Mansour, Anis Ben Haj Khalifa, Safia Dahmen, Pierre Chatre, Marisa Haenni, Mahjoub Aouni, Jean-Yves Madec
Molecular features of the first carbapenem-resistant Klebsiella pneumoniae isolates (KP1 and KP2) from the University Hospital Tahar Sfar, Tunisia, were investigated. Antimicrobial susceptibility testing, multilocus sequence typing, S1 nuclease pulsed-field gel electrophoresis, Southern blot, and polymerase chain reaction (PCR)-based replicon typing were performed. Extended-spectrum β-lactamases and carbapenemase genes were detected by PCR and sequencing. Both isolates were multidrug resistant. KP1 was of sequence type (ST) ST101 and exhibited blaCTX-M-15 and blaTEM-1 on an untypeable plasmid and blaOXA-48 on an IncL/M plasmid...
March 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/26341707/dissemination-of-multidrug-resistant-blactx-m-15-incfiik-plasmids-in-klebsiella-pneumoniae-isolates-from-hospital-and-community-acquired-human-infections-in-tunisia
#16
Wejdene Mansour, Raoudha Grami, Anis Ben Haj Khalifa, Safia Dahmen, Pierre Châtre, Marisa Haenni, Mahjoub Aouni, Jean-Yves Madec
This study investigated the molecular features of extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae from hospital- and community-acquired (HA/CA) infections in the region of Mahdia, Tunisia. Among 336 K. pneumoniae isolates recovered from both clinical contexts between July 2009 and December 2011, 49 and 15 were ESBL producers and originated from clinical and community sources, respectively. All isolates produced the CTX-M-15 enzyme. As shown by Southern blot on S1 nuclease treatment followed by pulsed-field gel electrophoresis (PFGE) gels, the blaCTX-M-15 gene was carried on IncFII (n=4), IncFIIk (n=25), IncL/M (n=4), IncK (n=1), or untypeable (n=15) plasmids in HA isolates...
November 2015: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/26218948/a-systematic-review-and-best-evidence-synthesis-of-the-effectiveness-of-therapeutic-facet-joint-interventions-in-managing-chronic-spinal-pain
#17
REVIEW
Laxmaiah Manchikanti, Alan D Kaye, Mark V Boswell, Sanjay Bakshi, Christopher G Gharibo, Vahid Grami, Jay S Grider, Sanjeeva Gupta, Sachin Sunny Jha, Dharam P Mann, Devi E Nampiaparampil, Manohar Lal Sharma, Lindsay N Shroyer, Vijay Singh, Amol Soin, Ricardo Vallejo, Bradley W Wargo, Joshua A Hirsch
BACKGROUND: The therapeutic spinal facet joint interventions generally used for the treatment of axial spinal pain of facet joint origin are intraarticular facet joint injections, facet joint nerve blocks, and radiofrequency neurotomy. Despite interventional procedures being common as treatment strategies for facet joint pathology, there is a paucity of literature investigating these therapeutic approaches. Systematic reviews assessing the effectiveness of various therapeutic facet joint interventions have shown there to be variable evidence based on the region and the modality of treatment utilized...
July 2015: Pain Physician
https://www.readbyqxmd.com/read/25074353/isolation-and-characterization-of-putative-endophytic-bacteria-antagonistic-to-phoma-tracheiphila-and-verticillium-albo-atrum
#18
Leila Kalai-Grami, Sabrine Saidi, Sarra Bachkouel, Imen Ben Slimene, Monia Mnari-Hattab, Mohamed Rebah Hajlaoui, Ferid Limam
A collection of 200 bacterial isolates recovered from citrus plants (Citrus limon, Citrus sinensis, and Citrus reticulata), Medicago truncatula and Laurus nobilis, was established. In vitro screening indicated that 28 isolates exhibited an inhibitory activity against the vascular pathogens Phoma tracheiphila and Verticillium albo-atrum. Isolates were screened according to their hydrolytic activities, plant growth-promoting bacteria (PGPB) abilities, as well as for the presence of nonribosomal peptide synthetase (NRPS) genes responsible of the lipopeptide biosynthesis...
September 2014: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/24904543/parasitic-chytrids-sustain-zooplankton-growth-during-inedible-algal-bloom
#19
Serena Rasconi, Boutheina Grami, Nathalie Niquil, Marlène Jobard, Télesphore Sime-Ngando
This study assesses the quantitative impact of parasitic chytrids on the planktonic food web of two contrasting freshwater lakes during different algal bloom situations. Carbon-based food web models were used to investigate the effects of chytrids during the spring diatom bloom in Lake Pavin (oligo-mesotrophic) and the autumn cyanobacteria bloom in Lake Aydat (eutrophic). Linear inverse modeling was employed to estimate undetermined flows in both lakes. The Monte Carlo Markov chain linear inverse modeling procedure provided estimates of the ranges of model-derived fluxes...
2014: Frontiers in Microbiology
https://www.readbyqxmd.com/read/24428239/blactx-m-15-carrying-f2-a-b-plasmid-in-escherichia-coli-from-cattle-milk-in-tunisia
#20
Raoudha Grami, Safia Dahmen, Wejdene Mansour, Wahib Mehri, Marisa Haenni, Mahjoub Aouni, Jean-Yves Madec
Extended-spectrum β-lactamases (ESBL) are widespread enzymes in animals, and the risk of transmission of ESBL genes to humans has become a major issue. In Tunisia, recent data showed a high prevalence of ESBL-producing Escherichia coli isolates in healthy animals, mostly in chickens. In this study, we report the first data on ESBL in diseased Tunisian animals (chickens and cattle), highlighting a major difference in ESBL prevalence in the infectious versus noninfectious E. coli flora. Interestingly, the only ESBL producer was an ST10 E...
August 2014: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
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