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I Matetovici, J Van Den Abbeele
Thioester-containing proteins (TEPs) are conserved proteins with a role in innate immune immunity. In the current study, we characterized the TEP family in the genome of six tsetse fly species (Glossina spp.). Tsetse flies are the biological vectors of several African trypanosomes, which cause sleeping sickness in humans or nagana in livestock. The analysis of the tsetse TEP sequences revealed information about their structure, evolutionary relationships and expression profiles under both normal and trypanosome infection conditions...
March 12, 2018: Insect Molecular Biology
Javier Iglesias-Sigüenza, Cristina Izquierdo, Elena Díez, Rosario Fernández, José M Lassaletta
The direct dialkylation of triazolo[4,3-b]isoquinolin-3-ylidene structures readily affords dicationic N-heterotricyclic azolium salts. These are suitable starting materials for the synthesis of transition metal complexes containing N-heterotricyclic, cationic ligands characterized by extended charge delocalization. Silver and gold complexes as well as mono- and dicationic rhodium(i) complexes have been prepared and characterized, and the electronic properties of the ligand have been evaluated by using the TEP parameter and by comparison with a non-cationic analogue...
March 12, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Eva Ortega-Retuerta, Cèlia Marrasé, Ana Muñoz-Fernández, M Montserrat Sala, Rafel Simó, Josep M Gasol
Transparent Exopolymer Particles (TEPs) are a subclass of organic particles with high impact in biogeochemical and ecological processes, such as the biological carbon pump, air-sea interactions, or the microbial loop. However, the complexity in production and consumption makes TEP dynamics hardly predictable, calling for the need of descriptive studies about the in situ dynamics of these particles. We followed monthly TEP dynamics and combined them with a dataset of environmental variables during three years in a coastal site of the oligotrophic North Western Mediterranean (Blanes Bay)...
March 8, 2018: Science of the Total Environment
Hirofumi Kawanaka, Shoji Hiroshige, Nobuhide Kubo, Teijiro Hirashita, Takeshi Masuda, Yushi Kaisyakuji, Tadahiro Tajiri, Akinori Egashira, Toshifumi Matsumoto, Tokujiro Yano
BACKGROUND: Obturator hernia (OH) is a rare but serious disease associated with high morbidity and mortality because of patients' advanced age and comorbidities. This study evaluated the feasibility of a laparoscopic approach for OH. STUDY DESIGN: We retrospectively reviewed the records of 32 patients (median age: 84 years; 31 women) with OH treated between 2003 and 2016. RESULTS: Five patients with incidental OH underwent totally extraperitoneal (TEP) repair...
March 6, 2018: Journal of the American College of Surgeons
C V van Hessen, J P J Burgmans, E J M M Verleisdonk
- With around 30,000 interventions a year, correction of an inguinal hernia is one of the most commonly performed surgeries in the Netherlands. One would therefore expect the same technique to be used all over the world by now. There are nevertheless different procedures, depending on a patient's age and history, the type of inguinal hernia and the expertise of the surgeon.- When the pathophysiology of an inguinal hernia became clear at the end of the 19th century, Bassini laid the foundation of modern inguinal hernia surgery: reinforcing the posterior wall of the inguinal canal after repositioning the hernial sac with its contents...
2018: Nederlands Tijdschrift Voor Geneeskunde
Alexander M Gorbushin
The evolution of complement system in invertebrates is poorly investigated. While the repertoire of complement genes in several Ecdysozoa lineages is found substantially different from that of Deuterostomia, the composition and function of the complement in the second protostome lineage, Lophotrochozoa, remains unclear. Here we report the general description of new transcriptomic data on the common periwinkle, Littorina littorea, and trace the evolutionary trajectories of the ancestral proto-complement repertoire...
February 28, 2018: Developmental and Comparative Immunology
Chandra Kishor Jakhmola, Ameet Kumar, Shivraj Singh Chauhan
BACKGROUND: A laparoscopic approach to repair of inguinal hernia has become popular. The reduction of an indirect sac can be challenging especially if it is long standing or is large. In such situations, the established practice is to divide the sac at the neck and ligate it. Ligation of the sac has been shown to cause increased postoperative pain. Hence we postulated that we could possibly avoid ligation of this divided sac without causing increased intraoperative difficulty or postoperative complications...
March 1, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Ruvanthi N Kularatne, Katherine E Washington, Chandima Bulumulla, Erika L Calubaquib, Michael C Biewer, David Oupicky, Mihaela C Stefan
The short chain fatty acid, 4-phenylbutyric acid (PBA), is used for the treatment of urea cycle disorders and sickle cell disease as an endoplasmic reticulum stress inhibitor. PBA is also known as a histone deacetylase inhibitor (HDACi). We report here the effect of combination therapy on HeLa cancer cells using PBA as the HDACi together with the anticancer drug, doxorubicin (DOX). We synthesized γ-4-phenylbutyrate-ε-caprolactone monomer which was polymerized to form poly(γ-4-phenylbutyrate-ε-caprolactone) (PPBCL) homopolymer using NdCl3 ·3TEP/TIBA (TEP = triethyl phosphate, TIBA = triisobutylaluminum) catalytic system...
February 27, 2018: Biomacromolecules
Ying Zhang, Xiaobo Zheng, Lifei Wei, Runxia Sun, Huiying Guo, Xinyu Liu, Shengyu Liu, Yi Li, Bixian Mai
Phosphate flame retardants (PFRs) were measured in surface water (n=11), suspended particle matter (SPM, n=11), sediment (n=11), and fish samples (n=26) from the Pearl River Delta located in South China. Triethyl phosphate (TEP), tri(2-chloroethyl) phosphate (TCEP), tris(chloroisopropyl) phosphate (TCIPP), tri-n-butyl phosphate (TNBP), triphenyl phosphate (TPHP), and tricresyl phosphate (TMPP) were detected in more than half of surface water, SPM, and sediment samples. The median ΣPFR levels were 837ng/L, 54...
February 21, 2018: Science of the Total Environment
Fernando Ruiz-Jasbon, Kristina Ticehurst, Jukka Ahonen, Jonny Norrby, Marie-Lois Ivarsson
Background and Objectives: The role of long-term degradable implants in reducing the risk of chronic postoperative pain after inguinal hernia repair is still unclear. A pilot study using a synthetic long-term resorbable mesh in Lichtenstein repair showed good results regarding pain and discomfort in patients with indirect inguinal hernia (IH) without recurrences, but higher recurrence rate in patients with direct inguinal hernia (DH). The purpose of this study was to assess the incidence of pain and early recurrence in patients with LIH surgically treated with the TEP technique using a long-term degradable mesh...
January 2018: JSLS: Journal of the Society of Laparoendoscopic Surgeons
Ulrich Steger, Markus Bisping, Jennifer Urban, Thorsten Vowinkel, Aloys Wiesmann, Jonathan Ryll
BACKGROUND: Whereas international guidelines recommend day surgery for endoscopic inguinal hernia repair, this approach is still controversial in Germany. In the light of international guidelines and at the request of patients, we have established total extraperitoneal patch plastic (TEP) surgery in the outpatient setting in our hospital. METHODS: A retrospective analysis of all unilateral TEP procedures carried out between January 2013 and December 2015 in our outpatient surgery, focused on postoperative complications, conversion to admission and rate of recurrence...
February 22, 2018: Zentralblatt Für Chirurgie
M Farkhondeh Fal, J Kircher
Shoulder arthroplasties in specialized centers are routine procedures with an increasing number of operations in the developed countries. Restoration of pain free shoulder function requires an intensive, specific and individual rehabilitation program for each patient. There is a phase-like course with different specific demands and measures that extends over a period of several weeks. Return to sport and a pain free function for activities of daily living resulting in a high patient satisfaction can routinely be expected...
February 22, 2018: Der Orthopäde
Upasana Shokal, Hannah Kopydlowski, Sneh Harsh, Ioannis Eleftherianos
Drosophila melanogaster is an outstanding model for studying host anti-pathogen defense. Although substantial progress has been made in understanding how metabolism and immunity are interrelated in flies, little information has been obtained on the molecular players that regulate metabolism and inflammation in Drosophila during pathogenic infection. Recently we have reported that inactivation of Thioester containing proteins 2 and 4 ( Tep2 and Tep4 ) promotes survival and decreases the bacterial burden in flies upon infection with the virulent pathogens Photorhabdus luminescens and P...
February 20, 2018: Infection and Immunity
Virak Khieu, Vandine Or, Chhakda Tep, Peter Odermatt, Reiko Tsuyuoka, Meng Chuor Char, Molly A Brady, Joshua Sidwell, Aya Yajima, Rekol Huy, Kapa D Ramaiah, Sinuon Muth
BACKGROUND: Endemicity of lymphatic filariasis (LF) in Cambodia was proven in 1956 when microfilariae were detected in mosquitos in the Kratié province. In 2001, an extensive study confirmed the presence of both Brugia malayi and Wuchereria bancrofti microfilariae. In 2003, the Ministry of Health established a national task force to develop policies and strategies for controlling and eliminating neglected tropical diseases (NTDs), with the goal of eliminating LF by 2015. This article summarizes the work accomplished to eliminate LF as a public health problem in Cambodia...
February 20, 2018: Infectious Diseases of Poverty
C-C Chiang, H-Y Yang, Y-C Hsu
BACKGROUND: While performing unilateral TEP herniorrhaphy, controversy still exists about whether to do contralateral exploration or not. Routine contralateral exploration has been proposed to prevent metachronous contralateral hernias by the repair of incidental contralateral occult hernias. Some surgeons have even proposed to do prophylactic bilateral TEP herniorrhaphy for unilateral hernia patients. To evaluate the appropriateness of not doing contralateral exploration in unilateral TEP herniorrhaphy, we reviewed our experiences under our practice of no contralateral exploration and we also reviewed other published literature...
February 19, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
Zhi Li, Hai-Song Shi, Ori Elis, Zhuo-Ya Yang, Ya Wang, Simon S Y Lui, Eric F C Cheung, Ann M Kring, Raymond C K Chan
The Temporal Experience of Pleasure Scale (TEPS) is a self-report instrument that assesses pleasure experience. Initial scale development and validation in the United States yielded a two-factor solution comprising anticipatory and consummatory pleasure. However, a four-factor model that further parsed anticipatory and consummatory pleasure experience into abstract and contextual components was a better model fit in China. In this study, we tested both models using confirmatory factor analysis in an American and a Chinese sample and examined the configural measurement invariance of both models across culture...
February 12, 2018: PsyCh Journal
Byung Jo Choi, Won Jun Jeong, Sang Chul Lee
BACKGROUND: Mesh fixation minimizes the risk of recurrence following laparoscopic inguinal hernia repair. Mesh fixation using staples has been implicated as a cause of chronic inguinal pain. We investigated whether fibrin glue mesh fixation reduces acute or chronic postoperative pain in patients undergoing single-port laparoscopic totally extraperitoneal inguinal hernia repair (SP TEP). METHODS: Inguinal hernia patients undergoing SP TEP between October 2013 and September 2016 were evaluated...
February 1, 2018: International Journal of Surgery
Outi Kaarre, Marja Äikiä, Elisa Kallioniemi, Mervi Könönen, Virve Kekkonen, Noora Heikkinen, Petri Kivimäki, Tommi Tolmunen, Sara Määttä, Eila Laukkanen
The most thoroughly studied transcranial magnetic stimulation (TMS)-evoked electroencephalogram (EEG) potential (TEP), N100, is often defined as a measure of cortical inhibition. We explored the association of the N100 amplitude with attention in 51 young healthy adults. Navigated TMS with simultaneous EEG registering was applied over the left primary motor cortex at the intensity of 110% of the resting motor threshold. Attention was assessed with the Paced Auditory Serial Addition Test (PASAT). We found a negative Pearson correlation (p = ...
January 30, 2018: Brain and Cognition
Ioannis Baloyiannis, Konstantinos Perivoliotis, Chamaidi Sarakatsianou, George Tzovaras
BACKGROUND: General anesthesia has been used as a standard for laparoscopic inguinal hernia repair including both techniques (Trans-Abdominal Pre-Peritoneal repair and the Total Extra-Peritoneal repair), while regional anesthesia has been occasionally applied in high risk patients where general anesthesia is contraindicated. In case of the total extraperitoneal repair (TEP), several authors have attempted to perform TEP repair under regional anesthesia and reported on the safety and feasibility of this procedure...
February 5, 2018: Surgical Endoscopy
Ryosuke Haraguchi, Shun Hoshino, Tatsuro Yamazaki, Shin-Ichi Fukuzawa
A chiral triazolylidene-Pd-PEPPSI (PEPPSI = pyridine, enhanced, precatalyst, preparation, stabilization, initiation) complex with ferrocene-based planar chirality has been synthesized and characterized. Investigation of the electronic and steric nature of this complex revealed its powerful electron-donating ability (TEP 2044 cm-1) and high steric bulk (%Vbur = 42.2). These unique properties allow the complex to exhibit very high catalytic activity (TON = 420) for asymmetric Suzuki-Miyaura cross-coupling, providing the coupling product with good enantioselectivity (75% ee)...
February 6, 2018: Chemical Communications: Chem Comm
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