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https://www.readbyqxmd.com/read/29139566/patient-reported-rates-of-chronic-pain-and-recurrence-after-groin-hernia-repair
#1
K-J Lundström, H Holmberg, A Montgomery, P Nordin
BACKGROUND: The effectiveness of different procedures in routine surgical practice for hernia repair with respect to chronic postoperative pain and reoperation rates is not clear. METHODS: This was prospective cohort study based on a unique combination of patient-reported outcomes and national registry data. Virtually all patients with a groin hernia repair in Sweden between September 2012 and April 2015 were sent a questionnaire 1 year after surgery. Persistent pain, defined as at least 'pain present, cannot be ignored, and interferes with concentration on everyday activities' in the past week was the primary outcome...
November 15, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29123926/spinal-excitability-changes-after-transspinal-and-transcortical-paired-associative-stimulation-in-humans
#2
Maria Knikou
Paired associative stimulation (PAS) produces enduring neuroplasticity based on Hebbian associative plasticity. This study established the changes in spinal motoneuronal excitability by pairing transcortical and transspinal stimulation. Transcortical stimulation was delivered after (transspinal-transcortical PAS) or before (transcortical-transspinal PAS) transspinal stimulation. Before and after 40 minutes of each PAS protocol, spinal neural excitability was assessed based on the amplitude of the transspinal-evoked potentials (TEPs) recorded from ankle muscles of both legs at different stimulation intensities (recruitment input-output curve)...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/29118096/the-sgc-beyond-structural-genomics-redefining-the-role-of-3d-structures-by-coupling-genomic-stratification-with-fragment-based-discovery
#3
REVIEW
Anthony R Bradley, Aude Echalier, Michael Fairhead, Claire Strain-Damerell, Paul Brennan, Alex N Bullock, Nicola A Burgess-Brown, Elisabeth P Carpenter, Opher Gileadi, Brian D Marsden, Wen Hwa Lee, Wyatt Yue, Chas Bountra, Frank von Delft
The ongoing explosion in genomics data has long since outpaced the capacity of conventional biochemical methodology to verify the large number of hypotheses that emerge from the analysis of such data. In contrast, it is still a gold-standard for early phenotypic validation towards small-molecule drug discovery to use probe molecules (or tool compounds), notwithstanding the difficulty and cost of generating them. Rational structure-based approaches to ligand discovery have long promised the efficiencies needed to close this divergence; in practice, however, this promise remains largely unfulfilled, for a host of well-rehearsed reasons and despite the huge technical advances spearheaded by the structural genomics initiatives of the noughties...
November 8, 2017: Essays in Biochemistry
https://www.readbyqxmd.com/read/29104528/the-effect-of-lamotrigine-and-levetiracetam-on-tms-evoked-eeg-responses-depends-on-stimulation-intensity
#4
Isabella Premoli, Alyssa Costantini, Davide Rivolta, Andrea Biondi, Mark P Richardson
The combination of transcranial magnetic stimulation and electroencephalography (TMS-EEG) has uncovered underlying mechanisms of two anti-epileptic medications: levetiracetam and lamotrigine. Despite their different mechanism of action, both drugs modulated TMS-evoked EEG potentials (TEPs) in a similar way. Since both medications increase resting motor threshold (RMT), the current aim was to examine the similarities and differences in post-drug TEPs, depending on whether stimulation intensity was adjusted to take account of post-drug RMT increase...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29096215/intermittent-theta-burst-stimulation-induces-correlated-changes-in-cortical-and-corticospinal-excitability-in-healthy-older-subjects
#5
Tamara Gedankien, Peter J Fried, Alvaro Pascual-Leone, Mouhsin M Shafi
OBJECTIVE: We studied the correlation between motor evoked potentials (MEPs) and early TMS-evoked EEG potentials (TEPs) from single-pulse TMS before and after intermittent Theta Burst Stimulation (iTBS) to the left primary motor cortex (M1) in 17 healthy older participants. METHODS: TMS was targeted to the hand region of M1 using a MRI-guided navigated brain stimulation system and a figure-of-eight biphasic coil. MEPs were recorded from the right first dorsal interosseous muscle using surface EMG...
September 28, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29075973/seroma-following-transabdominal-preperitoneal-patch-plasty-tapp-incidence-risk-factors-and-preventive-measures
#6
F Köckerling, R Bittner, D Adolf, R Fortelny, H Niebuhr, F Mayer, C Schug-Pass
BACKGROUND: The reported range of seroma formation in the literature after TEP repair is between 0.5 and 12.2% and for TAPP between 3.0 and 8.0%. Significant clinical factors associated with seroma formation include old age, a large hernia defect, an extension of the hernia sac into the scrotum, as well as the presence of a residual indirect sac. Seroma formation is a frequent complication of laparoendoscopic mesh repair of moderate to large-size direct (medial) inguinal hernia defects...
October 26, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29074250/esc-derived-thymic-epithelial-cells-expressing-mog-prevents-eae-by-central-and-peripheral-tolerance-mechanisms
#7
Min Su, Yujun Lin, Cheng Cui, Xiaohong Tian, Xiuling Lu, Zhixu He, Laijun Lai
Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS), and is induced by immunization with disease-causative self-antigens such as myelin oligodendrocyte glycoprotein (MOG). We have previously reported that transplantation of MOG expressing thymic epithelial progenitors (TEPs) derived from 129S6SvEv Tac mouse embryonic stem cells (mESCs) prevented the development of EAE. In this study, we expand our previous studies to show that transplantation of MOG expressing mESC-TEPs derived from C57BL/6 mice also prevents EAE development...
October 18, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29070499/identifying-and-characterizing-preventable-adverse-drug-events-for-prioritizing-pharmacist-intervention-in-hospitals
#8
Nakyung Jeon, Ben Staley, Thomas Johns, Glori Pflugfelder Lipori, Babette Brumback, Richard Segal, Almut G Winterstein
PURPOSE: The approach and results for identifying and characterizing preventable adverse drug events (pADEs) that are key targets for pharmacist medication therapy management (MTM) are summarized. METHODS: This study was part of a larger effort aimed at developing an electronic health record-based prediction model (the complexity score, or C-score) that ranks hospitalized patients according to their risk for pADEs. An environmental scan of published epidemiologic pADE studies and national patient safety priority areas was conducted...
November 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29066315/surgery-website-as-a-24-7-adjunct-to-a-surgical-curriculum
#9
Apram Jyot, Mohamed S Baloul, Eric J Finnesgard, Samuel J Allen, Nimesh D Naik, Miguel A Gomez Ibarra, Eduardo F Abbott, Becca Gas, Francisco J Cardenas-Lara, Muhammad H Zeb, Rachel Cadeliña, David R Farley
OBJECTIVE: Successfully teaching duty hour restricted trainees demands engaging learning opportunities. Our surgical educational website and its associated assets were assessed to understand how such a resource was being used. DESIGN: Our website was accessible to all Mayo Clinic employees via the internal web network. Website access data from April 2015 through October 2016 were retrospectively collected using Piwik. SETTING: Academic, tertiary care referral center with a large general surgery training program...
October 21, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29053262/carotenoid-singlet-fission-reactions-in-bacterial-light-harvesting-complexes-as-revealed-by-triplet-excitation-profiles
#10
Jie Yu, Li-Min Fu, Long-Jiang Yu, Ying Shi, Peng Wang, Zheng-Yu Wang-Otomo, Jian-Ping Zhang
Carotenoids (Cars) in bacterial photosynthesis are known as accessory light harvesters and photoprotectors. Recently, the singlet fission (SF) reaction initiated by Car photoabsorption has been recognized to be an effective excitation deactivation channel disfavoring the light harvesting function. Since the SF reaction and the triplet sensitization reaction underlying photoprotection both yield triplet excited state Cars ((3)Car*), their contribution to the overall (3)Car* photoproduction are difficult to disentangle...
November 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29040943/liquid-chromatography-tandem-mass-spectrometry-direct-injection-analysis-of-organophosphorus-flame-retardants-in-ontario-surface-water-and-wastewater-effluent
#11
Chunyan Hao, Paul A Helm, David Morse, Eric J Reiner
Organophosphorus flame retardants (OPFRs) started to be used in plastics, electronics and furnishings back in the 1960s and became popular again last decade. They are now widely present in the environment and regarded as "new" emerging organic pollutants. An effective liquid chromatography-tandem mass spectrometry (LC-MS/MS) direct injection analysis (DIA) method was developed to monitor OPFR levels in aquatic environment. The removal of sample extraction and concentration steps not only improved operation efficiency, but also reduced the potential contamination commonly observed during the sample preparation process before...
October 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/29038901/pre-peritoneal-local-anaesthetic-does-not-reduce-post-operative-pain-in-laparoscopic-total-extra-peritoneal-inguinal-hernia-repair-double-blinded-randomized-controlled-trial
#12
S Kulasegaran, M Rohan, L Pearless, M Hulme-Moir
PURPOSE: Laparoscopic total extra-peritoneal hernia repair (TEP) is associated with less post-operative pain and earlier return to normal activity compared to open hernia repair (OHP). Despite this, post-operative pain remains a major issue. The aim of this double-blinded randomized controlled trial was to identify whether the instillation of local anaesthetic in the pre-peritoneal space improves pain scores following TEP. METHODS: One hundred patients undergoing laparoscopic total pre-peritoneal hernia repair (TEP) between the years of 2009-2014 were included...
October 16, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29019555/impact-of-obesity-and-surgical-skills-in-laparoscopic-totally-extraperitoneal-hernioplasty
#13
Juliana Mika Kato, Leandro Ryuchi Iuamoto, Fábio Yuji Suguita, Felipe Futema Essu, Alberto Meyer, Wellington Andraus
BACKGROUND: Laparoscopic totally extraperitoneal (TEP) hernia repair is a technically demanding procedure. Recent studies have identified BMI as an independent factor for technical difficulty in the learning period. AIM: To analyze the effect of overweight and obesity on the technical difficulties of TEP. METHOD: Prospective study on patients who underwent a symptomatic inguinal hernia by means of the TEP technique. Were analyzed gender, BMI, previous surgery, hernia type, operative time and complications...
July 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28988854/dynamics-of-phytoplankton-productivity-and-exopolysaccharides-eps-and-tep-pools-in-the-seine-estuary-france-normandy-over-tidal-cycles-and-over-two-contrasting-seasons
#14
Jérôme Morelle, Mathilde Schapira, Pascal Claquin
Exopolysaccharides (EPS) play an important role in the carbon flux and may be directly linked to phytoplankton and microphytobenthos production, most notably in estuarine systems. However the temporal and spatial dynamics of estuarine EPS are still not well understood, nor how primary productivity triggers this variability at these different scales. The aim of this study was to investigate the primary productivity of phytoplankton and EPS dynamics in the Seine estuary over a tidal cycle in three different haline zones over two contrasted seasons...
October 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28984276/role-of-charged-impurities-in-thermoelectric-transport-in-molybdenum-disulfide-monolayers
#15
Sukanya B Patil, N S Sankeshwar, B G Mulimani
A theoretical study of the electronic properties, namely, electrical conductivity (EC), electronic thermal conductivity (ETC) and thermoelectric power (TEP) in 2D MoS<sub>2</sub> monolayers (MLs), over a wide range of temperatures (10<T<300 K), is presented employing Boltzmann transport formalism. Considering the electrons to be scattered by screened charged impurities and the acoustic, optical and remote phonons, the transport equation is solved using Ritz iterative method. Numerical calculations of EC, ETC and TEP presented for supported and free-standing MLs with high electron concentrations, as a function of temperature, bring out the relative importance of the various scattering mechanisms operative...
October 6, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28970180/cadaveric-dissection-vs-homemade-model-what-is-the-best-way-to-teach-endoscopic-totally-extraperitoneal-inguinal-hernia-repair
#16
Yazan AlJamal, EeeLN Buckarma, Raaj Ruparel, Samuel Allen, David Farley
BACKGROUND: Endoscopic totally extraperitoneal inguinal hernia repair (TEP-IHR) requires practice and training to perform well. We developed a simple, low-cost, inanimate model to teach surgical residents inguinal anatomy and the technique of mesh insertion for a safe, endoscopic TEP-IHR. The objective of this study was to compare our model vs cadaveric dissection for teaching anatomy and mesh insertion. METHODS: A total of 14 general surgery residents participated in an institutional review board approved, prospective, and randomized study...
September 29, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28964552/3d-printed-tracheoesophageal-puncture-and-prosthesis-placement-simulator
#17
Samuel R Barber, Elliott D Kozin, Matthew R Naunheim, Rosh Sethi, Aaron K Remenschneider, Daniel G Deschler
OBJECTIVES: A tracheoesophageal prosthesis (TEP) allows for speech after total laryngectomy. However, TEP placement is technically challenging, requiring a coordinated series of steps. Surgical simulators improve technical skills and reduce operative time. We hypothesize that a reusable 3-dimensional (3D)-printed TEP simulator will facilitate comprehension and rehearsal prior to actual procedures. METHODS: The simulator was designed using Fusion360 (Autodesk, San Rafael, CA)...
August 18, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28959774/reducing-dnacpr-complaints-to-zero-designing-and-implementing-a-treatment-escalation-plan-using-quality-improvement-methodology
#18
Elizabeth Shermon, Laura Munglani, Sarah Oram, Linda William, Julian Abel
INTRODUCTION: Do Not Attempt Resuscitation (DNAR)decisions have traditionally formed the basis of ceiling of care discussions. However, poor quality discussions can lead to high patient and relative dissatisfaction, generating hospital complaints. Treatment escalation plans (TEPs) aim to highlight the wider remit of treatment options with a focus on effective communication. We aimed to improve TEP discussions and documentation at Weston General Hospital by introducing a standardised form...
2017: BMJ Open Qual
https://www.readbyqxmd.com/read/28956622/expression-of-the-teta-gene-encoding-teta-efflux-protein-in-e-coli-contributes-to-its-increased-bacterial-resistance-toward-berberine
#19
Ying Li, Zhe-Tong Cao, Xin-Yue Wang, Xi-Zhen Ge
Berberine (BBR) is a traditional Chinese medicine in various applications due to its antibacterial effect. Here we investigated the increased bacterial resistance of E. coli toward BBR. The median effective concentration (EC50) of BBR against E. coli was increased when TetA efflux protein (TEP) was introduced. Sixty-five percent of the intracellular BBR was expelled and molecular docking demonstrated the intensive interaction of TEP to BBR. Finally, the combined antibacterial experiment identified that BBR acted as an inhibitor of TEP in detoxification of tetracycline...
September 28, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28953552/lichtenstein-versus-total-extraperitoneal-patch-plasty-versus-transabdominal-patch-plasty-technique-for-primary-unilateral-inguinal-hernia-repair-a-registry-based-propensity-score-matched-comparison-of-57-906-patients
#20
Ferdinand Köckerling, Reinhard Bittner, Michael Kofler, Franz Mayer, Daniela Adolf, Andreas Kuthe, Dirk Weyhe
OBJECTIVE: Outcome comparison of the Lichtenstein, total extraperitoneal patch plasty (TEP), and transabdominal patch plasty (TAPP) techniques for primary unilateral inguinal hernia repair. BACKGROUND: For comparison of these techniques the number of cases included in meta-analyses of randomized controlled trials is limited. There is therefore an urgent need for more comparative data. METHODS: In total, 57,906 patients with a primary unilateral inguinal hernia and 1-year follow up from the Herniamed Registry were selected between September 1, 2009 and February 1, 2015...
September 26, 2017: Annals of Surgery
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