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https://www.readbyqxmd.com/read/29342443/test-retest-reliability-of-transcranial-magnetic-stimulation-eeg-evoked-potentials
#1
Lewis J Kerwin, Corey J Keller, Wei Wu, Manjari Narayan, Amit Etkin
BACKGROUND: Transcranial magnetic stimulation (TMS)-evoked potentials (TEPs), recorded using electroencephalography (TMS-EEG), offer a powerful tool for measuring causal interactions in the human brain. However, the test-retest reliability of TEPs, critical to their use in clinical biomarker and interventional studies, remains poorly understood. OBJECTIVE/HYPOTHESIS: We quantified TEP reliability to: (i) determine the minimal TEP amplitude change which significantly exceeds that associated with simply re-testing, (ii) locate the most reliable scalp regions of interest (ROIs) and TEP peaks, and (iii) determine the minimal number of TEP pulses for achieving reliability...
December 29, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29332240/preperitoneal-closed-system-suction-drainage-after-totally-extraperitoneal-hernioplasty-in-the-prevention-of-early-seroma-formation-a-prospective-double-blind-randomised-controlled-trial
#2
J K M Fan, J Liu, K Chen, X Yang, X Xu, H K Choi, F S Y Chan, K W H Chiu, C M Lo
OBJECTIVES: Seroma is a virtually unavoidable early sequela after TEP hernioplasty. This randomised controlled trial evaluated the outcomes of preperitoneal closed-system suction drainage in laparoscopic totally extraperitoneal (TEP) hernioplasty for inguinal hernia. METHODS: Ninety patients aged 18-80 years who presented to our hospital between May 2016 and February 2017 with primary unilateral inguinal hernia were randomised into the preperitoneal drain and no-drain groups...
January 13, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29330871/multi-site-n-glycan-mapping-study-2-uhplc
#3
Ákos Szekrényes, SungAe Suhr Park, Eoin Cosgrave, Aled Jones, Ted Haxo, Michael Kimzey, Shiva Pourkaveh, Zoltán Szabó, Zoran Sosic, Peng Feng, Preeti Sejwal, Kelsey Dent, David Michels, Gordon Freckleton, Jun Qian, Catherine Lancaster, Toni Duffy, Melissa Schwartz, Jiann-Kae Luo, Jonathan van Dyck, Pui-King Leung, Marcell Olajos, Ronald Kowle, Kai Gao, Wenbo Wang, Jo Wegstein, Samnang Tep, Apolka Domokos, Csaba Váradi, András Guttman
In the first part of this publication, the results from an international study evaluating the precision (i.e., repeatability and reproducibility) of N-glycosylation analysis using capillary electrophoresis of APTS-labeled N-glycans were presented. The corresponding results from ultra-high performance liquid chromatography (UHPLC) with fluorescence detection are presented here from 12 participating sites. All participants used the same lot of samples, reagents, and columns to perform the assays. Elution time, peak area and peak area percent values were determined for all peaks ≥0...
January 13, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29330835/international-guidelines-for-groin-hernia-management
#4
(no author information available yet)
INTRODUCTION: Worldwide, more than 20 million patients undergo groin hernia repair annually. The many different approaches, treatment indications and a significant array of techniques for groin hernia repair warrant guidelines to standardize care, minimize complications, and improve results. The main goal of these guidelines is to improve patient outcomes, specifically to decrease recurrence rates and reduce chronic pain, the most frequent problems following groin hernia repair. They have been endorsed by all five continental hernia societies, the International Endo Hernia Society and the European Association for Endoscopic Surgery...
January 12, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29328533/cobaltocenylidene-a-mesoionic-metalloceno-carbene-stabilized-in-a-gold-iii-complex
#5
Benno Bildstein, Stefan Vanicek, Maren Podewitz, Christopher Hassenrück, Michael Pittracher, Holger Kopacka, Klaus Wurst, Thomas Müller, Klaus R Liedl, Rainer F Winter
Oxidative addition of cobaltoceniumdiazonium bis(hexafluoridophosphate) with (pseudo)halide aurates afforded gold(III) complexes containing zwitterionic cobaltoceniumide as a ligand. Its selenium derivative, cobaltoceniumselenolate, was obtained by an electrophilic aromatic substitution reaction of iodocobaltocenium iodide with Na2Se. Spectroscopic and structural data in combination with DFT calculations show that this cobaltocenylidene species is a mesoionic carbene quite different from common N-heterocyclic carbenes...
January 12, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29319458/efficacy-of-self-hypnosis-on-quality-of-life-for-children-with-chronic-pain-syndrome
#6
Honorine Delivet, Sophie Dugue, Alexis Ferrari, Silvia Postone, Souhayl Dahmani
The aim of this study was to assess the efficacy of self-hypnosis in a therapeutic education program (TEP) for the management of chronic pain in 26 children aged 7 to 17 years. Outcomes of the study were a total or a partial (at least 1) achievement of the therapeutic goals (pain, quality of sleeping, schooling, and functional activity). Sixteen patients decreased their pain intensity, 10 reached all of their therapeutic goals, and 9 reached them partially. Self-hypnosis was the only component of the TEP associated with these improvements...
January 2018: International Journal of Clinical and Experimental Hypnosis
https://www.readbyqxmd.com/read/29317185/cortical-inhibition-assessed-using-paired-pulse-tms-eeg-is-increased-in-older-adults
#7
George M Opie, Simranjit K Sidhu, Nigel C Rogasch, Michael C Ridding, John G Semmler
BACKGROUND: Alterations in inhibitory processes mediated by gamma-aminobutyric acid type B (GABAB) receptors may contribute to age-related functional impairments. However, investigation of these circuits using conventional paired-pulse transcranial magnetic stimulation (TMS) at long interstimulus intervals (∼100-200ms) have produced conflicting results in older adults, possibly due to the indirect nature of the TMS motor evoked potential (MEP). OBJECTIVE: To utilise electroencephalography and TMS coregistration (TMS-EEG) to more directly assess age-related changes in GABAB-mediated long-interval intracortical inhibition (LICI)...
December 30, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29314458/quality-of-omeprazole-purchased-via-the-internet-and-personally-imported-into-japan-comparison-with-products-sampled-in-other-asian-countries
#8
Mohammad Sofiqur Rahman, Naoko Yoshida, Sakura Sugiura, Hirohito Tsuboi, Tep Keila, Heng Bun Kiet, Theingi Zin, Tsuyoshi Tanimoto, Kazuko Kimura
OBJECTIVE: To evaluate the quality of omeprazole personally imported into Japan via the internet and to compare the quality of these samples with previously collected samples from two other Asian countries. METHODS: The samples were evaluated by observation, authenticity investigation, and pharmacopoeial quality analysis. Quality comparison of some selected samples was carried out by dissolution profiling, Raman spectroscopy, and principle component analysis (PCA)...
January 5, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29306196/organophosphate-esters-in-east-greenland-polar-bears-and-ringed-seals-adipose-tissue-concentrations-and-in%C3%A2-vitro-depletion-and-metabolite-formation
#9
Adelle Strobel, William G Willmore, Christian Sonne, Rune Dietz, Robert J Letcher
East Greenland is a contamination "hot spot" for long-range transported anthropogenic chemicals, including organophosphate esters (OPEs). High concentrations of OPEs have been reported in arctic air while very little is known for wildlife where OPE tissue residues levels appear to be strongly influenced by biotransformation. In the present study, the hepatic in vitro metabolism of six environmentally relevant organophosphate (OP) triesters and corresponding OP diester formation were investigated in East Greenland polar bears (PBs) and ringed seals (RSs)...
December 29, 2017: Chemosphere
https://www.readbyqxmd.com/read/29306024/organophosphate-triesters-and-selected-metabolites-enhance-binding-of-thyroxine-to-human-transthyretin-in-vitro
#10
Katie L Hill, Timo Hamers, Jorke H Kamstra, William G Willmore, Robert J Letcher
The toxicological properties of organophosphate (OP) triesters that are used as flame retardants and plasticizers are currently not well understood, though increasing evidence suggests they can affect the thyroid system. Perturbation of thyroid hormone (TH) transport is one mechanism of action that may affect thyroid function. The present study applied an in vitro competitive protein binding assay with thyroxine (T4) and human transthyretin (hTTR) to determine the potential for the OP triesters, TDCIPP (tris(1,3-dichloro-2-propyl) phosphate), TBOEP (tris(butoxyethyl) phosphate), TEP (triethyl phosphate), TPHP (triphenyl phosphate), p-OH-TPHP (para-hydroxy triphenyl phosphate), and the OP diester DPHP (diphenyl phosphate), to competitively displace T4 from hTTR...
January 3, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29303810/higher-recurrence-rate-after-endoscopic-totally-extraperitoneal-tep-inguinal-hernia-repair-with-ultrapro-lightweight-mesh-5-year-results-of-a-randomized-controlled-trial-tulp-trial
#11
Marleen Roos, Wouter J Bakker, Nelleke Schouten, Charlotte Voorbrood, Geert Jan Clevers, Egbert Jan Verleisdonk, Paul Davids, Josephina Burgmans
OBJECTIVE: The aim of this study was to determine inguinal hernia recurrence rates 5 years after endoscopic totally extraperitoneal (TEP) inguinal hernia repair when either lightweight or heavyweight mesh was used. BACKGROUND: Recurrence is an important complication of inguinal hernia surgery. Higher recurrence rates of Ultrapro lightweight meshes after TEP repair have been demonstrated, yet data regarding long-term follow-up are limited. METHODS: From 2010 to 2012, 950 male adult patients with primary unilateral hernias were randomized to TEP hernia repair with heavyweight (Prolene) or lightweight (Ultrapro) mesh...
January 4, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29299648/has-shouldice-repair-in-a-selected-group-of-patients-with-inguinal-hernia-comparable-results-to-lichtenstein-tep-and-tapp-techniques
#12
F Köckerling, A Koch, D Adolf, T Keller, R Lorenz, R H Fortelny, C Schug-Pass
BACKGROUND: In the new international guidelines only the mesh-based Lichtenstein, TEP and TAPP techniques are recommended. This present analysis of data from the Herniamed Registry compares the outcome for Shouldice versus Lichtenstein, TEP and TAPP. METHODS: Propensity score matching analyses were performed to obtain homogeneous comparison groups for Shouldice versus Lichtenstein (n = 2115/2608; 81.1%), Shouldice versus TEP (n = 2225/2608; 85.3%) and Shouldice versus TAPP (2400/2608; 92...
January 3, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29297987/elective-laparoscopic-totally-extraperitoneal-repair-for-spigelian-hernia-a-case-series-of-four-patients
#13
Tsz Ting Law, Ka Kin Ng, Lily Ng, Kin Yuen Wong
INTRODUCTION: Spigelian hernia (SH) is uncommon. Clinical diagnosis may be difficult, but computed tomography (CT) can help to establish the diagnosis. Laparoscopic repair is increasingly performed because it is associated with low morbidity rates. Laparoscopic approaches include transabdominal preperitoneal (TAPP), intraperitoneal onlay mesh (IPOM), and totally extraperitoneal (TEP). Here, we report our experiences of TEP repair for SH. METHODS: A retrospective review was performed on all patients with SH who underwent elective laparoscopic TEP repair from 2007 to 2017 at Tung Wah Hospital, Hong Kong...
January 3, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29280482/national-trends-in-primary-tracheoesophageal-puncture-after-total-laryngectomy
#14
Rosh K V Sethi, Daniel G Deschler
OBJECTIVES/HYPOTHESIS: Tracheoesophageal puncture (TEP) can be performed at the time of laryngectomy (primary) or postoperatively (secondary). Prior studies demonstrate safe and earlier voice acquisition and rehabilitation with primary TEP. The objectives of this study were to assess national trends in primary TEP and identify factors associated with its use. STUDY DESIGN: Retrospective review. METHODS: Retrospective analysis of the Nationwide Inpatient Sample (NIS) from 2010 to 2014 was performed...
December 27, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29250511/efficacy-and-safety-of-a-novel-partially-absorbable-mesh-in-totally-extraperitoneal-hernia-repair
#15
Hsien Wen Yang, Sang Hee Kang, Sung Yeop Jung, Byung Wook Min, Sun Il Lee
Purpose: Partially absorbable mesh has been introduced and used for inguinal hernia repair for the purpose of minimizing pain and improving abdominal wall compliance. In this study, we evaluate the efficacy and safety of ProFlex mesh, a partially absorbed mesh with new structural architecture. Methods: We retrospectively reviewed 64 cases of totally extraperitoneal herniorrhapy (TEP) from January 2013 to December 2014 for their clinical features, including operation time, pain, postoperative complications, and recurrence...
December 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29229335/determination-of-organophosphorus-flame-retardants-in-fish-by-freezing-lipid-precipitation-solid-phase-extraction-and-gas-chromatography-mass-spectrometry
#16
Yin-E Liu, Li-Qian Huang, Xiao-Jun Luo, Xiao-Xin Tan, Chen-Chen Huang, Pablo Zapata Corella, Bi-Xian Mai
An analytical method has been developed for measuring 12 organophosphorus flame retardants (PFRs) in fish tissue samples. After the Soxhlet extraction of PFRs with dichloromethane. The experimental parameters of the clean-up were systematically optimized. Methanol was found to be a more effective solvent than acetonitrile used in freezing-lipid precipitation. Methanol (5%) in ultrapure water, was finally selected to perform solid-phase extraction (SPE, Oasis HLB cartridge), with mean lipid removal efficiency of 94% after freezing-lipid precipitation...
December 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29218268/blood-based-tumor-biomarkers-in-lung-cancer-for-detection-and-treatment
#17
REVIEW
Hirva Mamdani, Shahid Ahmed, Samantha Armstrong, Tony Mok, Shadia I Jalal
The therapeutic landscape of lung cancer has expanded significantly over the past decade. Advancements in molecularly targeted therapies, strategies to discover and treat resistance mutations, and development of personalized cancer treatments in the context of tumor heterogeneity and dynamic tumor biology have made it imperative to obtain tumor samples on several different occasions through the course of patient treatment. While this approach is critical to the delivery of optimal cancer treatment, it is fraught with a number of barriers including the need for invasive procedures with associated complications, access to limited amount of tissue, logistical delays in obtaining the biopsy, high healthcare cost, and in many cases inability to obtain tissue because of technically difficult location of the tumor...
December 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29217627/the-gastric-caecum-of-larval-aedes-aegypti-stimulation-of-epithelial-ion-transport-by-5-hydroxytryptamine-and-camp
#18
Natalie M D'Silva, Michael J O'Donnell
We report measurements of ion transport across the gastric caecum of larvae of Aedes aegypti, a vector of yellow fever that inhabits a variety of aquatic habitats ranging from freshwater to brackish water. We provide the first measurements of the effect of 5-hydroxytryptamine (5-HT) on transepithelial potential (TEP), luminal ion concentrations and electrochemical potentials, as well as basolateral membrane potential and H+, Na+ and K+ fluxes. TEP, basolateral membrane potential, and H+, K+, and Na+ fluxes across the gastric caeca declined within 3-6 mins after isolation of the entire midgut from the larva...
December 7, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29214677/highly-electrophilic-catalytically-active-and-redox-responsive-cobaltoceniumyl-and-ferrocenyl-triazolylidene-coinage-metal-complexes
#19
Stefan Vanicek, Maren Podewitz, Jessica Stubbe, Dennis Schulze, Holger Kopacka, Klaus Wurst, Thomas Müller, Petra Lippmann, Simone Haslinger, Herwig Schottenberger, Klaus R Liedl, Ingo Ott, Biprajit Sarkar, Benno Bildstein
A convenient access to a triad of triazoles with ferrocenyl and cobaltoceniumyl substituents are reported. N-Alkylation, deprotonation and metalation with CuI/AgI/AuI synthons affords the heteroleptic triazolylidene complexes. Due to the combination of neutral, electron-donating ferrocenyl substituents and cationic, strongly electron-withdrawing cobaltocenium substituents, the mesoionic carbene (MIC) ligands of these complexes are electronically interesting "push-pull", "pull-push" and "pull-pull" metalloligands with further switchable redox states based on their fully reversible FeII/FeIII, (ferrocene/ferrocenium) and CoIII/CoII, (cobaltocenium/cobaltocene) redox couples...
December 7, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29213090/evaluation-of-short-interval-cortical-inhibition-and-intracortical-facilitation-from-the-dorsolateral-prefrontal-cortex-in-patients-with-schizophrenia
#20
Yoshihiro Noda, Mera S Barr, Reza Zomorrodi, Robin F H Cash, Faranak Farzan, Tarek K Rajji, Robert Chen, Zafiris J Daskalakis, Daniel M Blumberger
GABAergic and glutamatergic dysfunction in the dorsolateral prefrontal cortex (DLPFC) are thought to be the core pathophysiological mechanisms of schizophrenia. Recently, we have established a method to index these functions from the DLPFC using the paired transcranial magnetic stimulation (TMS) paradigms of short interval intracortical inhibition (SICI) and facilitation (ICF) combined with electroencephalography (EEG). In this study, we aimed to evaluate neurophysiological indicators related to GABAA and glutamate receptor-mediated functions respectively from the DLPFC in patients with schizophrenia using these paradigms, compared to healthy controls...
December 6, 2017: Scientific Reports
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