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https://www.readbyqxmd.com/read/28446927/the-experience-and-awareness-of-laparoendoscopic-procedures-among-polish-surgeons-in-everyday-clinical-practice
#1
Kryspin Mitura, Stanisław Dąbrowiecki, Maciej Śmietański, Andrzej Matyja
INTRODUCTION: In 2012, a total of 56 647 inguinal hernia repairs were performed in Poland. However, the absence of a uniform hernia repair register obscures the current herniology status in Poland, especially regarding laparoendoscopic procedures. AIM: To determine the awareness of laparoendoscopic procedures among Polish surgeons and to ascertain their everyday clinical practice. MATERIAL AND METHODS: The data were collected at the national hernia conference in 2016, during an interactive session for surgeons with a special interest in herniology...
2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/28437669/white-matter-microstructural-abnormalities-and-their-association-with-anticipatory-anhedonia-in-depression
#2
Xin-Hua Yang, Yi Wang, Dong-Fang Wang, Kai Tian, Eric F C Cheung, Guang-Rong Xie, Raymond C K Chan
Anhedonia is associated with dysfunction of the neural circuitry of reward in patients with major depressive disorder (MDD). However, its neurobiological basis is not fully understood. The present study examined the association between anhedonia and white matter (WM) characteristics in patients with first-episode MDD. We recruited 30 patients with first-episode drug-naive MDD and 28 healthy controls (HC) to undergo diffusion weighted imaging. We examined specifically the correlation between WM characteristics and anhedonia measured with the Temporal Experience of Pleasure Scale (TEPS) in MDD patients...
April 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28427955/preventing-alcohol-and-tobacco-exposed-pregnancies-choices-plus-in-primary-care
#3
Mary M Velasquez, Kirk L von Sternberg, R Louise Floyd, Danielle Parrish, Alicia Kowalchuk, Nanette S Stephens, Britta Ostermeyer, Charles Green, J Paul Seale, Patricia Dolan Mullen
INTRODUCTION: Alcohol and tobacco use are common among U.S. women, yet if used during pregnancy these substances present significant preventable risks to prenatal and perinatal health. Because use of alcohol and tobacco often continue into the first trimester and beyond, especially among women with unintended pregnancies, effective evidence-based approaches are needed to decrease these risk behaviors. This study was designed to test the efficacy of CHOICES Plus, a preconception intervention for reducing the risk of alcohol- and tobacco-exposed pregnancies (AEPs and TEPs)...
April 17, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28425686/if-time-matters-a-multicentre-review-of-minimally-invasive-hernia-repair-in-7176-cases
#4
Kai Witzel, Michael Weitzendorfer
BACKGROUND: In endoscopic hernia repair TEP and TAPP are seen as equivalent surgical techniques in quality, but not in procedure-time. METHODS: We compared the two most common procedures in endoscopic hernia surgery. Focussing on the duration of the surgical procedure, we analyzed 7176 endoscopic hernia operations in 25 hospitals retrospectively and compared it to the literature. RESULTS: In our study TEP (n=2799) took on average 59 minutes, TAPP (n=4377) took 67...
April 19, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/28417279/tackers-versus-glue-mesh-fixation-an-objective-assessment-of-postoperative-acute-and-chronic-pain-using-inflammatory-markers
#5
W Liew, Y Y Wai, N R Kosai, H S Gendeh
PURPOSE: Laparoscopic hernioplasty has become a popular choice for inguinal hernia repair since its advent in 1990s. Postoperative pain is an undesirable clinical outcome impairing daily activity of 22.5% of patients. The aim of this study is to evaluate postoperative acute and chronic pain via inflammatory markers as an objective assessment following tacks or glue mesh fixation in TEP repair. METHODS: Sixty-six (66) patients with unilateral uncomplicated inguinal hernia were randomized into 34 patients in the tacker and 32 patients in cyanoacrylate glue mesh fixation in TEP repair...
April 17, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28384197/the-influence-of-corticospinal-activity-on-tms-evoked-activity-and-connectivity-in-healthy-subjects-a-tms-eeg-study
#6
Sara Petrichella, Nessa Johnson, Bin He
Combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) can be used to analyze cortical reactivity and connectivity. However, the effects of corticospinal and peripheral muscle activity on TMS-evoked potentials (TEPs) are not well understood. The aim of this paper is to evaluate the relationship between cortico-spinal activity, in the form of peripheral motor-evoked potentials (MEPs), and the TEPs from motor areas, along with the connectivity among activated brain areas. TMS was applied to left and right motor cortex (M1), separately, at motor threshold while multi-channel EEG responses were recorded in 17 healthy human subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28379529/reduced-short-latency-afferent-inhibition-in-prefrontal-but-not-motor-cortex-and-its-association-with-executive-function-in-schizophrenia-a-combined-tms-eeg-study
#7
Yoshihiro Noda, Mera S Barr, Reza Zomorrodi, Robin F H Cash, Tarek K Rajji, Faranak Farzan, Robert Chen, Tony P George, Zafiris J Daskalakis, Daniel M Blumberger
BACKGROUND: Cholinergic dysfunction is increasingly assumed to be involved in the pathophysiology of schizophrenia. Short-latency afferent inhibition (SAI) is a transcranial magnetic stimulation (TMS) paradigm that has been shown to assay central cholinergic activity from the motor cortex (M1). Recently, we established a method to index SAI from the dorsolateral prefrontal cortex (DLPFC), an area implicated in the pathophysiology of schizophrenia. We investigated SAI in M1 and DLPFC in schizophrenia...
April 1, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28361038/tick-thioester-containing-proteins-and-phagocytosis-do-not-affect-transmission-of-borrelia-afzelii-from-the-competent-vector-ixodes-ricinus
#8
Veronika Urbanová, Ondřej Hajdušek, Helena Hönig Mondeková, Radek Šíma, Petr Kopáček
The present concept of the transmission of Lyme disease from Borrelia-infected Ixodes sp. ticks to the naïve host assumes that a low number of spirochetes that manage to penetrate the midgut epithelium migrate through the hemocoel to the salivary glands and subsequently infect the host with the aid of immunomodulatory compounds present in tick saliva. Therefore, humoral and/or cellular immune reactions within the tick hemocoel may play an important role in tick competence to act as a vector for borreliosis...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28350024/generalization-of-the-tolman-electronic-parameter-the-metal-ligand-electronic-parameter-and-the-intrinsic-strength-of-the-metal-ligand-bond
#9
Dieter Cremer, Elfi Kraka
The catalytic activity of transition metal complexes (R)nM-L can be predicted utilizing the metal-ligand electronic parameter (MLEP) that is based on the local stretching force constant of the M-L bond. Vibrational spectroscopy is an excellent tool to accurately determine vibrational mode properties such as stretching frequencies. These correspond, because of mode-mode coupling, to delocalized vibrational modes, which have to be first converted into local vibrational modes, and their properties. Each bond of a molecule can be uniquely characterized by the local stretching force constant and frequency...
March 28, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28342126/learning-curve-takes-65-repetitions-of-totally-extraperitoneal-laparoscopy-on-inguinal-hernias-for-reduction-of-operating-time-and-complications
#10
Fábio Yuji Suguita, Felipe Futema Essu, Lucas Torres Oliveira, Leandro Ryuchi Iuamoto, Juliana Mika Kato, Matheus Beloni Torsani, André Silva Franco, Alberto Meyer, Wellington Andraus
BACKGROUND: Inguinal hernia repair is one of the most frequently conducted surgical procedures worldwide. Totally extraperitoneal (TEP) hernioplasty has shown many advantages over traditional open surgery. However, because of increased surgical complexity, it requires more practice to achieve optimal results. OBJECTIVES: The aim of this study is to evaluate the learning curve for TEP hernioplasty, analysing parameters related to the mean operating time. The secondary objective is to assess the complications and early discharge rates related to this procedure...
March 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28340773/label-free-molecular-beacons-based-cascade-amplification-dna-machine-for-sensitive-detection-of-telomerase-activity
#11
Kan Li, Lei Wang, Xiaowen Xu, Wei Jiang
Sensitive detection of telomerase activity is critical to cancer diagnosis, screening of anticancer drugs and evaluation of cancer therapy. Herein, a label-free molecular beacons-based DNA machine was developed for sensitive detection of telomerase activity. The DNA machine consisted of T7 exonuclease (T7 Exo), label-free recognition molecular beacon (RMB) and signal molecular beacon (SMB) with projecting 5'-terminuses, which can protect RMB and SMB from being digested by T7 Exo. Firstly, telomerase elongated telomerase substrate (TS) primer, generating a telomerase elongation production (TEP) with tandem repeats (TTAGGG)n...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28337532/transition-from-laparoscopic-totally-extraperitoneal-inguinal-hernia-repair-to-robotic-transabdominal-preperitoneal-inguinal-hernia-repair-a-retrospective-review-of-a-single-surgeon-s-experience
#12
Omar Yusef Kudsi, Justin C McCarty, Nivedh Paluvoi, Allan S Mabardy
BACKGROUND: There is a paucity of literature comparing laparoscopic to robotic inguinal hernia repair. We present a single surgeon's transition from laparoscopic totally extraperitoneal (L-TEP) to robotic transabdominal preperitoneal (R-TAPP) inguinal hernia repair and compare outcomes from the two approaches. METHODS: This retrospective review and analysis of prospectively collected data compare outcomes during the transition from L-TEP to R-TAPP inguinal hernia repair by a single surgeon at one institution...
March 23, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28331144/totally-extraperitoneal-tep-removal-of-an-infected-mesh-by-laparoscopy-after-open-preperitoneal-repair-initial-case-report
#13
Naoto Chihara, Keisuke Mishima, Hideyuki Suzuki, Masanori Watanabe, Tetsutaka Toyoda, Eiji Uchida
Prosthetic mesh infection after open or laparoscopic hernia repair is a rare complication. Superficial wound infection can be resolved by treatment with a combination of antibiotics and wound drainage, whereas deep-seated mesh infection, which can lead to chronic groin sepsis, usually requires removal of the mesh. A 56-year-old Japanese man was admitted to our hospital for the treatment of deep-seated mesh infection. The patient had undergone inguinal hernia repair at another hospital 18 months earlier. The operation was prosthetic mesh repair via an anterior approach...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28318017/thymic-crosstalk-restrains-the-pool-of-cortical-thymic-epithelial-cells-with-progenitor-properties
#14
Catarina Meireles, Ana R Ribeiro, Rute D Pinto, Catarina Leitão, Pedro M Rodrigues, Nuno L Alves
Cortical (cTEC) and medullary (mTEC) thymic epithelial cells establish key microenvironments for T-cell differentiation and arise from thymic epithelial cell progenitors (TEP). However, the nature of TEPs and the mechanism controlling their stemness in the postnatal thymus remain poorly defined. Using TEC clonogenic assays as a surrogate to survey TEP activity, we found that a fraction of cTECs generates specialized clonal-derived colonies, which contain cells with sustained colony-forming capacity (ClonoTECs)...
March 20, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28296629/mini-totally-extra-peritoneal-repair-of-inguinal-hernia-with-all-5%C3%A2-mm-ports-an-innovative-555-technique
#15
Manish K Gupta, Kiran Kumar Muley, Murali Krishna Bethanbhatla, Juhil D Nanavati, Kumar Manish, Rathindra Sarangi
BACKGROUND: Totally extra-peritoneal (TEP) repair of inguinal hernia is now a standard surgical technique. A 12 mm incision in infra-umbilical region for Hasson trocar is must for TEP repair of inguinal hernia. This is the only technique known to laparoscopic surgeons. We have innovated a "555 Technique" for completing Mini TEP repair of inguinal hernia by using all three 5 mm ports. METHODS: Sixty-one consecutive patients were subjected for TEP repair of inguinal hernia by our innovative "555 Technique" since October 2014...
March 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28278046/multilayered-polyion-complexes-with-dissolvable-silica-layer-covered-by-controlling-densities-of-crgd-conjugated-peg-chains-for-cancer-targeted-sirna-delivery
#16
Mitsuru Naito, Ryota Azuma, Hiroyasu Takemoto, Mao Hori, Naoto Yoshinaga, Shigehito Osawa, Rimpei Kamegawa, Hyun Jin Kim, Takehiko Ishii, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
Surface functionalization of nanoparticles is a crucial factor for nanoparticle-mediated drug and nucleic acid delivery. Particularly, the density of targeting ligands on nanoparticle significantly affects the affinity of nanoparticles to specific cellular surface (or receptor) through the multivalent binding effect. Herein, multilayered polyion complexes (mPICs) are prepared to possess varying densities of cyclic RGD peptide (cRGD) ligands for cancer-targeted small interfering RNA (siRNA) delivery. A template PIC is first prepared by mixing siRNAs with homo catiomers of N-substituted polyaspartamide bearing tetraethylenepentamine (PAsp(TEP)) in aqueous solution, followed by silica-coating through silicate condensation reaction...
March 12, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28277106/premenstrual-syndrome-and-fibromyalgia-the-frequency-of-the-coexistence-and-their-effects-on-quality-of-life
#17
Feray Soyupek, Cigdem Aydogan, Mehmet Guney, Seyit Ali Kose
OBJECTIVE: We aimed to investigate the association between Premenstrual syndrome (PMS) and fibromyalgia syndrome (FMS), to assess common symptoms and quality of life (QOL) of them. METHODS: Patients with PMS formed the PMS group and age-matched healthy normal controls were included in the control group. The diagnosis of the FMS and PMS were based on new American College of Rheumatology FMS criteria and DSM-IV PMS criteria. FMS-related symptoms assessed by visual analog scale and number of tender points (TePs) were analyzed...
March 5, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28274831/effects-of-prefrontal-bipolar-and-high-definition-transcranial-direct-current-stimulation-on-cortical-reactivity-and-working-memory-in-healthy-adults
#18
Aron T Hill, Nigel C Rogasch, Paul B Fitzgerald, Kate E Hoy
Transcranial direct current stimulation (tDCS) is a well-recognised neuromodulatory technology which has been shown to induce short-lasting changes in motor-cortical excitability. The recent and rapid expansion of tDCS into the cognitive domain, however, necessitates deeper mechanistic understanding of its neurophysiological effects over non-motor brain regions. The present study utilised transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) to probe the immediate and longer-term effects of both a bipolar (BP-tDCS) and more focal 4×1 High-Definition tDCS (HD-tDCS) montage applied over the left DLPFC on TMS-evoked potentials (TEPs) and oscillations in 19 healthy adult participants...
March 6, 2017: NeuroImage
https://www.readbyqxmd.com/read/28273465/a-knockin-reporter-allows-purification-and-characterization-of-mda-neurons-from-heterogeneous-populations
#19
Ninuo Xia, Fang Fang, Pengbo Zhang, Jun Cui, Chhavy Tep-Cullison, Tim Hamerley, Hyun Joo Lee, Theo Palmer, Brian Bothner, Jin Hyung Lee, Renee Reijo Pera
Generation of midbrain dopaminergic (mDA) neurons from human pluripotent stem cells provides a platform for inquiry into basic and translational studies of Parkinson's disease (PD). However, heterogeneity in differentiation in vitro makes it difficult to identify mDA neurons in culture or in vivo following transplantation. Here, we report the generation of a human embryonic stem cell (hESC) line with a tyrosine hydroxylase (TH)-RFP (red fluorescent protein) reporter. We validated that RFP faithfully mimicked TH expression during differentiation...
March 7, 2017: Cell Reports
https://www.readbyqxmd.com/read/28272716/efficacy-and-safety-of-nbca-n-butyl-2-cyanoacrylate-medical-adhesive-for-patch-fixation-in-totally-extraperitoneal-prosthesis-tep-a-prospective-randomized-controlled-trial
#20
Y-M Shen, Y-T Liu, J Chen, L Sun
OBJECTIVE: To evaluate the effectiveness of n-butyl-2-cyanoacrylate (NBCA) medical adhesive for mesh fixation in totally extraperitoneal prosthesis (TEP) for inguinal hernia repair. PATIENTS AND METHODS: A total of 160 patients with primary unilateral inguinal hernia were assigned randomly to receive TEP using NBCA medical adhesive for patch fixation (experimental group) and without patch fixation (control group). We evaluated operation time, visual analogue scale (VAS) pain score 24 h after surgery, postoperative duration of stay, hospital costs, postoperative complications, and hernia recurrence...
February 2017: European Review for Medical and Pharmacological Sciences
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