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JOURNAL ARTICLE
Andrew Sumarsono, Luyu Xie, Neil Keshvani, Chenguang Zhang, LajjaBen Patel, Windy Alonso, Jennifer Thibodeau, Gregg C Fonarow, Harriette G C Van Spall, Sarah E Messiah, Ambarish Pandey
BACKGROUND: Guideline-directed medical therapies (GDMTs) are the mainstay of treatment for heart failure with reduced ejection fraction (HFrEF), but they are underused. Whether sex differences exist in the initiation and intensification of GDMT for newly diagnosed HFrEF is not well established. METHODS: Patients with incident HFrEF were identified from the 2016 to 2020 Optum deidentified Clinformatics Data Mart Database, which is derived from a database of administrative health claims for members of large commercial and Medicare Advantage health plans...
January 23, 2024: Circulation
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JOURNAL ARTICLE
Désirée Klemann, Windi Winasti, Fleur Tournois, Helen Mertens, Frits van Merode
In this study, we consider the human body and the healthcare system as two complex networks and use theories regarding entropy, requisite variety, and network centrality metrics with resilience to assess and quantify the strengths and weaknesses of healthcare systems. Entropy is used to quantify the uncertainty and variety regarding a patient's health state. The extent of the entropy defines the requisite variety a healthcare system should contain to be able to treat a patient safely and correctly. We use network centrality metrics to visualize and quantify the healthcare system as a network and assign the strengths and weaknesses of the network and of individual agents in the network...
December 24, 2023: Entropy
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JOURNAL ARTICLE
Nadia Ansari, Furqan Kabir, Waqasuddin Khan, Farah Khalid, Amyn Abdul Malik, Joshua L Warren, Usma Mehmood, Abdul Momin Kazi, Inci Yildirim, Windy Tanner, Hussain Kalimuddin, Samiah Kanwar, Fatima Aziz, Arslan Memon, Muhammad Masroor Alam, Aamer Ikram, John Scott Meschke, Fyezah Jehan, Saad B Omer, Muhammad Imran Nisar
BACKGROUND: Wastewater-based surveillance is used to track the temporal patterns of the SARS-CoV-2 virus in communities. Viral RNA particle detection in wastewater samples can indicate an outbreak within a catchment area. We describe the feasibility of using a sewage network to monitor SARS-CoV-2 trend and use of genomic sequencing to describe the viral variant abundance in an urban district in Karachi, Pakistan. This was among the first studies from Pakistan to demonstrate the surveillance for SARS-CoV-2 from a semi-formal sewage system...
January 2024: Lancet Reg Health Southeast Asia
#24
RANDOMIZED CONTROLLED TRIAL
Jennifer Kaci Fairchild, Jonathan Myers, Peter Louras, Booil Jo, Margaret Windy McNerney, Joachim Hallmayer, Jerome Yesavage
OBJECTIVE: To investigate the preliminary efficacy of a combined physical exercise + cognitive training intervention for older adults with amnestic mild cognitive impairment (aMCI). DESIGN: Randomized clinical trial. SETTING: Veteran Affairs Hospital, Palo Alto, CA. PARTICIPANTS: Sample included 72 community-dwelling volunteers (mean age 72.4 ± 9.5) diagnosed with aMCI. INTERVENTION: Participants were randomized to either a combined aerobic and resistance exercise + cognitive training (CARE+CT) or stretching exercise + CT (SE+CT)...
April 2024: American Journal of Geriatric Psychiatry
#25
JOURNAL ARTICLE
Tomas A Melgarejo, Margaret K Cespedes, Li-Fang Chen, Thomas Turini, Patricia A Lazicki, Amber Vinchesi-Vahl, Robert L Gilbertson
In the western United States, curly top disease (CTD) is caused by beet curly top virus (BCTV). In California, CTD causes economic loss to processing tomato production in central and southern areas but, historically, not in the north. Here, we document unusual CTD outbreaks in processing tomato fields in the northern production area in 2021 and 2022, and show that these were caused by the rare spinach curly top strain (BCTV-SpCT). These outbreaks were associated with proximity of fields to foothills and unusually hot, dry, and windy spring weather conditions, possibly by altering migrations of the beet leafhopper (BLH) vector from locations with BCTV-SpCT reservoirs...
January 4, 2024: Virology
#26
JOURNAL ARTICLE
Jason A White, Ernest T Kaninjing, Kayode A Adeniji, Paul Jibrin, John O Obafunwa, Chidiebere N Ogo, Faruk Mohammed, Ademola Popoola, Omolara A Fatiregun, Olabode P Oluwole, Roland J Thorpe, Balasubramanyam Karanam, Isra Elhussin, Stefan Ambs, Wei Tang, Melissa Davis, Paz Polak, Moray J Campbell, Kathryn R Brignole, Solomon O Rotimi, Windy Dean-Colomb, Folake T Odedina, Clayton Yates
BACKGROUND: Through whole-exome sequencing of 60 formalin-fixed paraffin-embedded Nigerian (NGRn) benign prostatic hyperplasia (BPH) samples, we identified germline and somatic alterations in apoptotic pathways impacting BPH development and progression. Prostate enlargement is a common occurrence in male aging; however, this enlargement can lead to lower urinary tract symptoms that negatively impact quality of life. This impact is disproportionately present in men of African ancestry...
January 8, 2024: Prostate
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JOURNAL ARTICLE
Carrie L Nacht, Nora Jacobson, Olayinka Shiyanbola, Catherine Arnott Smith, Peter L T Hoonakker, Ryan J Coller, Shannon M Dean, Daniel J Sklansky, Windy Smith, Carley M Sprackling, Michelle M Kelly
OBJECTIVES: To explore the benefits and challenges of accessing physicians' notes during pediatric hospitalization across parents of different health literacy levels. METHODS: For this secondary analysis, we used semi-structured interviews conducted with 28 parents on their impressions of having access to their child's care team notes on a bedside table. Three researchers used thematic analysis to develop a codebook, coded interview data, and identified themes. Parent interviews and respective themes were then dichotomized into proficient or limited health literacy groups and compared...
January 4, 2024: Hospital Pediatrics
#28
JOURNAL ARTICLE
Wietse D Ledegang, Erik van der Burg, Pierre J L Valk, Mark M J Houben, Eric L Groen
BACKGROUND: In this study, we investigated the impact of a loss of horizon due to atmospheric conditions on flight performance and workload of helicopter pilots during a low-altitude, dynamic flight task in windy conditions at sea. We also examined the potential benefits of a helmet-mounted display (HMD) for this specific task. METHODS: In a fixed-based helicopter simulator, 16 military helicopter pilots were asked to follow a maneuvering go-fast vessel in a good visual environment (GVE) and in a degraded visual environment (DVE)...
January 1, 2024: Aerospace Medicine and Human Performance
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JOURNAL ARTICLE
Jeewon Choi, Natsuki Maeda, Ping Yeap Loh
This study investigated how different shapes of umbrella handles and grip types influence muscle activation and postural variability under windy conditions. Seventeen adult participants were enrolled in this study, and different handle shapes (cylindrical, ellipsoidal, and triangular prism-shaped), grip types (four- and five-finger grip), and wind strengths were tested. Activation of the forearm and upper arm muscles was recorded using surface electromyography. Postural variability and ratings of (1) perceived difficulty of use and (2) perceived grip-posture variability were measured...
December 27, 2023: Applied Ergonomics
#30
JOURNAL ARTICLE
Hayley E Billingsley, Marie-Pierre St-Onge, Windy W Alonso, Danielle L Kirkman, Youngdeok Kim, Salvatore Carbone
BACKGROUND AND AIMS: Promising associations have been demonstrated between delayed last eating occasion and cardiorespiratory fitness in adults with heart failure (HF), however, it is unknown if time of eating is associated with clinical endpoints such as mortality. This study aimed to examine associations between time of eating variables and all-cause and cardiovascular mortality in the National Health and Nutrition Examination Survey (NHANES). METHODS AND RESULTS: Participants self-disclosed HF diagnosis...
October 14, 2023: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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JOURNAL ARTICLE
Zoltán Török, Irankunda Elisephane, Alexandru Ozunu
Historically, Romania is known as a mining site of mineral substances, including gold, silver, copper, lead, zin, uranium, manganese, salt, and coal, whereby their long periods of exploitation and extraction affected human health and the environment in various ways. In Moldova Nouă southwest region of Romania, we investigated the environmental impacts of mining activities on air quality over 2021. We quantified PM10 emission rates through in situ monitoring, dispersion modelling, and horizontal and vertical fluxes...
December 19, 2023: Environmental Monitoring and Assessment
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JOURNAL ARTICLE
Windy Dwi Annisa, Fitri Aulia Permatasari, Ferry Iskandar, Heni Rachmawati
Precise visualization of biological processes necessitates reliable coloring technologies, and fluorescence imaging has emerged as a powerful method for capturing dynamic cellular events. Low emission intensity and solubility of intrinsic fluorescence are still challenging, hindering their application in the biomedical field. The nanostructurization and functionalization of the insoluble phytochemicals, such as chlorophyll and curcumin, into carbon dots (CDs) were conducted to address these challenges. Due to their unique fluorescence characteristics and biocompatibility, CDs derived from medicinal plants hold promise as bioimaging agents...
December 14, 2023: ACS Applied Bio Materials
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JOURNAL ARTICLE
Zizhen Yao, Cindy T J van Velthoven, Michael Kunst, Meng Zhang, Delissa McMillen, Changkyu Lee, Won Jung, Jeff Goldy, Aliya Abdelhak, Matthew Aitken, Katherine Baker, Pamela Baker, Eliza Barkan, Darren Bertagnolli, Ashwin Bhandiwad, Cameron Bielstein, Prajal Bishwakarma, Jazmin Campos, Daniel Carey, Tamara Casper, Anish Bhaswanth Chakka, Rushil Chakrabarty, Sakshi Chavan, Min Chen, Michael Clark, Jennie Close, Kirsten Crichton, Scott Daniel, Peter DiValentin, Tim Dolbeare, Lauren Ellingwood, Elysha Fiabane, Timothy Fliss, James Gee, James Gerstenberger, Alexandra Glandon, Jessica Gloe, Joshua Gould, James Gray, Nathan Guilford, Junitta Guzman, Daniel Hirschstein, Windy Ho, Marcus Hooper, Mike Huang, Madie Hupp, Kelly Jin, Matthew Kroll, Kanan Lathia, Arielle Leon, Su Li, Brian Long, Zach Madigan, Jessica Malloy, Jocelin Malone, Zoe Maltzer, Naomi Martin, Rachel McCue, Ryan McGinty, Nicholas Mei, Jose Melchor, Emma Meyerdierks, Tyler Mollenkopf, Skyler Moonsman, Thuc Nghi Nguyen, Sven Otto, Trangthanh Pham, Christine Rimorin, Augustin Ruiz, Raymond Sanchez, Lane Sawyer, Nadiya Shapovalova, Noah Shepard, Cliff Slaughterbeck, Josef Sulc, Michael Tieu, Amy Torkelson, Herman Tung, Nasmil Valera Cuevas, Shane Vance, Katherine Wadhwani, Katelyn Ward, Boaz Levi, Colin Farrell, Rob Young, Brian Staats, Ming-Qiang Michael Wang, Carol L Thompson, Shoaib Mufti, Chelsea M Pagan, Lauren Kruse, Nick Dee, Susan M Sunkin, Luke Esposito, Michael J Hawrylycz, Jack Waters, Lydia Ng, Kimberly Smith, Bosiljka Tasic, Xiaowei Zhuang, Hongkui Zeng
The mammalian brain consists of millions to billions of cells that are organized into many cell types with specific spatial distribution patterns and structural and functional properties1-3 . Here we report a comprehensive and high-resolution transcriptomic and spatial cell-type atlas for the whole adult mouse brain. The cell-type atlas was created by combining a single-cell RNA-sequencing (scRNA-seq) dataset of around 7 million cells profiled (approximately 4.0 million cells passing quality control), and a spatial transcriptomic dataset of approximately 4...
December 2023: Nature
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JOURNAL ARTICLE
Kimiko Inaoka, Ishak Halim Octawijaya, Citra Gabriella Mamahit, Jeand'arc Florentia Karundeng, Windy Mariane Virenia Wariki, Erika Ota
Second-hand smoke (SHS) has adverse effects for pregnant women and foetuses. This controlled and randomized clinical trial evaluated the efficacy of a comic booklet intervention in promoting SHS avoidance among pregnant women and appropriate smoking behaviours among their male partners. We allocated 140 couples to the experimental group (EG), who received the comic booklet and a reminder sticker, and 146 couples to the control group (CG), who received usual care. The primary outcomes were women's self-reported SHS exposure and their male partners' smoking behaviours...
November 28, 2023: Healthcare (Basel, Switzerland)
#35
JOURNAL ARTICLE
Susanne A Gatz, Anne C Harttrampf, Caroline Brard, Francisco Bautista, Nicolas Andre, Samuel Abbou, Jonathan Rubino, Windy Rondof, Marc Deloger, Marc Rübsam, Lynley V Marshall, Daniel Hubschmann, Souad Nebchi, Isabelle Aerts, Estelle Thebaud, Emilie De Carli, Anne Sophie Defachelles, Xavier Paoletti, Robert Godin, Kowser Miah, Peter G S Mortimer, Gilles Vassal, Birgit Geoerger
PURPOSE: AcSé-ESMART Arm C aimed to define the recommended dose and activity of the WEE1 inhibitor adavosertib in combination with carboplatin in children and young adults with molecularly enriched recurrent/refractory malignancies. PATIENTS AND METHODS: Adavosertib was administered orally, twice daily on Days 1 to 3 and carboplatin intravenously on Day 1 of a 21-day cycle, starting at 100 mg/m2/dose and AUC 5, respectively. Patients were enriched for molecular alterations in cell cycle and/or homologous recombination (HR)...
December 5, 2023: Clinical Cancer Research
#36
JOURNAL ARTICLE
Jinjuan Gao, David M Kennedy, Sarah McSweeney
Vegetation is a critical boundary condition for the stability of coastal dunes. Globally, vegetation cover is increasing on the coast with many dunes being stabilised in the past decades. This pattern is driven by site-specific (e.g., coastal management) and global (e.g., climatic changes) factors. This study examines changes in dune vegetation during the past six decades at the regional scale along the southeast coast of Australia to understand the relative importance of the climate and human interventions in vegetation cover change...
December 1, 2023: Journal of Environmental Management
#37
JOURNAL ARTICLE
Yu Liu, Jiujiang Wu, Tingting Huang, Weibo Nie, Zhifeng Jia, Yuhui Gu, Xiaoyi Ma
Soil desertification and salinization are important environmental concerns in arid regions, and their relationship with groundwater change must be further clarified. However, the relationships among soil desertification, salinization, and groundwater are difficult to investigate on a large spatiotemporal scale using traditional ground surveys. In the windy beach area in Northern Shaanxi (WBANS), desertification and salinization problems coexist; therefore, this area was selected as the study area. The feasibility of implementing large-scale remote sensing inversions to identify the degree of desertification and salinization was verified based on measured data, and the degree of influence of groundwater burial depth (GBD) on desertification and salinization was quantified using the geodetector and residual trend analysis methods...
November 29, 2023: Science of the Total Environment
#38
JOURNAL ARTICLE
Lu-Yi Wang, Chung-Ping Lin, Stanislav N Gorb, Hamed Rajabi
Enhanced attachment ability is common in plants on islands to avoid potential fatal passive dispersal. However, whether island insects also have increased attachment ability remains unclear. Here we measured the attachment of a flightless weevil, Pachyrhynchus sarcitis kotoensis , from tropical islands, and compared it with documented arthropods from the mainland. We examined the morphology and material gradient of its attachment devices to identify the specific adaptive modifications for attachment. We find that the weevil has much stronger attachment force and higher safety factor than previously studied arthropods, regardless of body size and substrate roughness...
November 2023: Journal of the Royal Society, Interface
#39
REVIEW
Aep Maulid Mulyana, Windy Rakhmawati, Riki Wartakusumah, Siti Yuyun Rahayu Fitri, Neti Juniarti
BACKGROUND: The incidence of chronic diseases in children is increasing worldwide, which can disrupt the quality of life. Family empowerment (FE) is one approach to strengthen family care among children with chronic diseases. In addition, internet has the potential in healthcare service interventions for families. PURPOSE: This study aimed to determine the efficacy of internet-based family empowerment interventions among children with chronic diseases. METHODS: The study used a mixed-methods systematic review...
2023: Journal of Multidisciplinary Healthcare
#40
JOURNAL ARTICLE
Faisal Abedin, Emiel DenHartog
Sportswear manufactured from hygroscopic fibres can absorb moisture during activity or intermittent exercise and may change the thermal management of clothing. This change in the thermal behaviour of the fabric can lead to buffer the post-exercise chill. During activity in a moderately cold environment clothing made of 100% wool fibre helps wearers to slow down evaporative and conductive cooling, which can provide more thermal and comfort sensation compared to 100% cotton, 100% viscose, and 100% polyester. Twelve males performed cycling in a controlled climate chamber of temperature: 15 ± 0...
November 14, 2023: Ergonomics
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