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https://www.readbyqxmd.com/read/29897978/moth-inspired-navigation-algorithm-in-a-turbulent-odor-plume-from-a-pulsating-source
#1
Alexander Liberzon, Kyra Harrington, Nimrod Daniel, Roi Gurka, Ally Harari, Gregory Zilman
Some female moths attract male moths by emitting series of pulses of pheromone filaments propagating downwind. The turbulent nature of the wind creates a complex flow environment, and causes the filaments to propagate in the form of patches with varying concentration distributions. Inspired by moth navigation capabilities, we propose a navigation strategy that enables a flier to locate an upwind pulsating odor source in a windy environment using a single threshold-based detection sensor. This optomotor anemotaxis strategy is constructed based on the physical properties of the turbulent flow carrying discrete puffs of odor and does not involve learning, memory, complex decision making or statistical methods...
2018: PloS One
https://www.readbyqxmd.com/read/29871859/taci-deficient-macrophages-protect-mice-against-metaflammation-and-obesity-induced-dysregulation-of-glucose-homeostasis
#2
Lunhua Liu, Karen Etsuko Inouye, Windy Rose Allman, Adam Steven Coleman, Shafiuddin Siddiqui, Gökhan Siddik Hotamisligil, Mustafa Akkoyunlu
Transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) is a receptor for the TNF superfamily cytokines, B cell activating factor (BAFF) and A Proliferation Inducing Ligand (APRIL). Here, we demonstrate that TACI-deficient mice subjected to high fat diet (HFD) are protected from weight gain and dysregulated glucose homeostasis. Resistance to HFD-induced metabolic changes in TACI-deficient mice does not involve TACI mediated adipogenesis. Instead, accumulation of M2 macrophages (Mϕs), eosinophils and type 2 innate lymphoid cells in visceral adipose tissue (VAT) is implicated in the protection from obesity induced assaults...
June 5, 2018: Diabetes
https://www.readbyqxmd.com/read/29779989/achilles-tendon-augmented-repair-using-human-acellular-dermal-matrix-a-case-series
#3
Windy Cole, Brian Samsell, Mark A Moore
Achilles tendon ruptures are common in the general population, especially among members of the older demographic occasionally active in sports. Operative treatments provide a lower incidence of rerupture than do nonoperative treatments, although surgical complications remain a concern. The use of a human acellular dermal matrix to augment Achilles tendon repair might reduce the incidence of complications. In the present case series, we describe the outcomes of 9 patients who underwent Achilles tendon repair with acellular dermal matrix augmentation...
May 17, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29733690/antibacterial-activity-of-indonesian-red-algae-gracilaria-edulis-against-bacterial-fish-pathogens-and-characterization-of-active-fractions
#4
Noer Kasanah, Windi Amelia, Amirul Mukminin, Triyanto, Alim Isnansetyo
In this study the crude ethyl acetate extracts and fractions from red algae Gracilaria edulis were studied against fish pathogens. G. edulis was extracted with ethyl acetate, fractionated in silica gel coloum chromatography and gradient hexane-ethyl acetate. The extract and fractions were subjected for bioassay guided isolation against fish pathogen Vibrio spp and Aeromonas hydrophila. Bioassays were accomplished by diffusion agar, bioauthography, and 96 well microplates format. Profiling chemical constituent was done by thin layer chromatography and GC-MS...
May 7, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29715911/variability-of-the-reflectance-coefficient-of-skylight-from-the-ocean-surface-and-its-implications-to-ocean-color
#5
Alexander Gilerson, Carlos Carrizo, Robert Foster, Tristan Harmel
The value and spectral dependence of the reflectance coefficient (ρ) of skylight from wind-roughened ocean surfaces is critical for determining accurate water leaving radiance and remote sensing reflectances from shipborne, AERONET-Ocean Color and satellite observations. Using a vector radiative transfer code, spectra of the reflectance coefficient and corresponding radiances near the ocean surface and at the top of the atmosphere (TOA) are simulated for a broad range of parameters including flat and windy ocean surfaces with wind speeds up to 15 m/s, aerosol optical thicknesses of 0-1 at 440nm, wavelengths of 400-900 nm, and variable Sun and viewing zenith angles...
April 16, 2018: Optics Express
https://www.readbyqxmd.com/read/29708061/use-of-a-deep-recurrent-neural-network-to-reduce-wind-noise-effects-on-judged-speech-intelligibility-and-sound-quality
#6
Mahmoud Keshavarzi, Tobias Goehring, Justin Zakis, Richard E Turner, Brian C J Moore
Despite great advances in hearing-aid technology, users still experience problems with noise in windy environments. The potential benefits of using a deep recurrent neural network (RNN) for reducing wind noise were assessed. The RNN was trained using recordings of the output of the two microphones of a behind-the-ear hearing aid in response to male and female speech at various azimuths in the presence of noise produced by wind from various azimuths with a velocity of 3 m/s, using the "clean" speech as a reference...
January 2018: Trends in Hearing
https://www.readbyqxmd.com/read/29669941/activating-prkacb-somatic-mutation-in-cortisol-producing-adenomas
#7
Stéphanie Espiard, Matthias J Knape, Kerstin Bathon, Guillaume Assié, Marthe Rizk-Rabin, Simon Faillot, Windy Luscap-Rondof, Daniel Abid, Laurence Guignat, Davide Calebiro, Friedrich W Herberg, Constantine A Stratakis, Jérôme Bertherat
Mutations in the gene encoding the protein kinase A (PKA) catalytic subunit α have been found to be responsible for cortisol-producing adenomas (CPAs). In this study, we identified by whole-exome sequencing the somatic mutation p.S54L in the PRKACB gene, encoding the catalytic subunit β (Cβ) of PKA, in a CPA from a patient with severe Cushing syndrome. Bioluminescence resonance energy transfer and surface plasmon resonance assays revealed that the mutation hampers formation of type I holoenzymes and that these holoenzymes were highly sensitive to cAMP...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29592845/use-of-social-network-sites-for-communication-among-health-professionals-systematic-review
#8
REVIEW
Windy Sy Chan, Angela Ym Leung
BACKGROUND: Although much research has been done investigating the roles of social network sites (SNSs) in linking patients and health professionals, there is a lack of information about their uses, benefits, and limitations in connecting health professions only for professional communication. OBJECTIVE: This review aimed to examine the utilization of SNSs for communication among health professionals in (1) frontline clinical practice, (2) professional networks, and (3) education and training to identify areas for future health communication research...
March 28, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29495729/effects-of-flow-gradients-on-directional-radiation-of-human-voice
#9
Ville Pulkki, Timo Lähivaara, Ilkka Huhtakallio
In voice communication in windy outdoor conditions, complex velocity gradients appear in the flow field around the source, the receiver, and also in the atmosphere. It is commonly known that voice emanates stronger towards the downstream direction when compared with the upstream direction. In literature, the atmospheric effects are used to explain the stronger emanation in the downstream direction. This work shows that the wind also has an effect to the directivity of voice also favouring the downstream direction...
February 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29415058/integration-of-neural-and-epigenetic-contributions-to-posttraumatic-stress-symptoms-the-role-of-hippocampal-volume-and-glucocorticoid-receptor-gene-methylation
#10
M Windy McNerney, Tong Sheng, Jordan M Nechvatal, Alex G Lee, David M Lyons, Salil Soman, Chun-Ping Liao, Ruth O'Hara, Joachim Hallmayer, Joy Taylor, J Wesson Ashford, Jerome Yesavage, Maheen M Adamson
Many Veterans exposed to physical and psychological trauma experience symptoms of posttraumatic stress disorder (PTSD). As the etiology of PTSD symptoms is complex, a better understanding of the underlying biological mechanisms may improve preventative care and treatment for PTSD. Recent findings from the fields of neuroimaging and epigenetics offer important insights into the potential brain structures and biochemical pathways of modified gene expression associated with PTSD. We combined neuroimaging and epigenetic measures to assess current PTSD symptoms by measuring overall hippocampal volume and methylation of the glucocorticoid receptor (GR) gene (promoter region)...
2018: PloS One
https://www.readbyqxmd.com/read/29378803/oral-manifestations-of-menopause-an-interprofessional-intervention-for-dental-hygiene-and-physician-assistant-students
#11
Windy L Rothmund, Ann D O'Kelley-Wetmore, Merri L Jones, Michael B Smith
Purpose: Interprofessional education (IPE) is a means of fostering integration and collaboration between health care professions. The purpose of this study was to evaluate the effect of an IPE educational module on dental hygiene (DH) and physician assistants (PA) students' knowledge of the oral manifestations of menopause and overall confidence in treating these conditions. Methods: A convenience sample of DH and PA students was used for this mixed-method study. Quantitative data was collected with pre- and post-tests using a modified Readiness for Interprofessional Learning Survey (RIPLS) and a principle investigator (PI)-designed knowledge of menopause test, to determine the students' attitudes and learning levels...
December 2017: Journal of Dental Hygiene: JDH
https://www.readbyqxmd.com/read/29358664/delayed-onset-of-autoreactive-antibody-production-and-m2-skewed-macrophages-contribute-to-improved-survival-of-taci-deficient-mrl-fas-lpr-mouse
#12
Lunhua Liu, Windy Rose Allman, Adam Steven Coleman, Kazuyo Takeda, Tsai-Lien Lin, Mustafa Akkoyunlu
Anti-B cell activating factor belonging to TNF-family (BAFF) antibody therapy is indicated for the treatment of patients with active systemic lupus erythematosus (SLE). We hypothesized that the BAFF receptor, transmembrane activator and calcium-modulator and cyclophilin interactor (TACI) may be responsible for the generation of antibody secreting plasma cells in SLE. To test this hypothesis, we generated TACI deficient MRL-Fas/Lpr (LPR-TACI-/-) mouse. TACI deficiency resulted in improved survival of MRL-Fas/Lpr mice and delayed production of anti-dsDNA and anti-SAM/RNP antibodies...
January 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29261719/improving-vehicle-tracking-rate-and-speed-estimation-in-dusty-and-snowy-weather-conditions-with-a-vibrating-camera
#13
Nastaran Yaghoobi Ershadi
Traffic surveillance systems are interesting to many researchers to improve the traffic control and reduce the risk caused by accidents. In this area, many published works are only concerned about vehicle detection in normal conditions. The camera may vibrate due to wind or bridge movement. Detection and tracking of vehicles is a very difficult task when we have bad weather conditions in winter (snowy, rainy, windy, etc.), dusty weather in arid and semi-arid regions, at night, etc. Also, it is very important to consider speed of vehicles in the complicated weather condition...
2017: PloS One
https://www.readbyqxmd.com/read/29204686/weather-conditions-influence-the-number-of-psychiatric-emergency-room-patients
#14
Eva Janina Brandl, Tristram A Lett, George Bakanidze, Andreas Heinz, Felix Bermpohl, Meryam Schouler-Ocak
The specific impact of weather factors on psychiatric disorders has been investigated only in few studies with inconsistent results. We hypothesized that meteorological conditions influence the number of cases presenting in a psychiatric emergency room as a measure of mental health conditions. We analyzed the number of patients consulting the emergency room (ER) of a psychiatric hospital in Berlin, Germany, between January 1, 2008, and December 31, 2014. A total of N = 22,672 cases were treated in the ER over the study period...
December 4, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29198307/a-bioequivalence-study-of-quetiapine-25-mg-film-coated-tablets-in-healthy-indonesian-subjects
#15
RANDOMIZED CONTROLLED TRIAL
Yahdiana Harahap, Budi Prasaja, Windy Lusthom, Lia Yumi Yusvita, Theresia Sinandang, Hardiyanti
AIM: This study was conducted in order to compare the bioavailability of two film-coated tablets containing 25 mg of quetiapine. METHODS: 24 subjects were enrolled in and completed a single-center, randomized, single-dose, open-label, two-way crossover study with a 1-week washout period. Plasma samples were collected up to 24 hours following drug administration; thus, quetiapine was determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method with turbo-ion-spray mode...
January 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29156456/impact-of-truncated-area-on-point-estimate-and-intra-subject-variability-in-bioequivalence-of-dutasteride-with-long-half-life
#16
Budi Prasaja, Yahdiana Harahap, Windy Lusthom, Lia Yumi, Anna Sofiana, Monica Sandra, Falah Safira, Uci Chilmi
PURPOSE: To investigate the effect of using truncated area under the curve (AUC0-72 ) on bioequivalence of dutasteride with long half-life in point estimate and intra-subject variability. METHODS: Fifteen subjects were enrolled in this single-dose, open-label, randomized two-way crossover design following an overnight fasting with five-week washout period. Plasma samples were collected to 72 h and 144 h following drug administration and dutasteride were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods...
April 2018: Drug Research
https://www.readbyqxmd.com/read/29102776/assessing-disease-modifying-effects-of-norepinephrine-in-down-syndrome-and-alzheimer-s-disease
#17
Ravikumar Ponnusamy, M Windy McNerney, Shahrzad Moghadam, Ahmad Salehi
Building upon the knowledge that a number of important brain circuits undergo significant degeneration in Alzheimer's disease, numerous recent studies suggest that the norepinephrine-ergic system in the brainstem undergoes significant alterations early in the course of both Alzheimer's disease and Down syndrome. Massive projections from locus coeruleus neurons to almost the entire brain, extensive innervation of brain capillaries, and widespread distribution of noradrenergic receptors enable the norepinephrine-ergic system to play a crucial role in neural processes, including cognitive function...
November 8, 2017: Brain Research
https://www.readbyqxmd.com/read/29081549/tundra-water-budget-and-implications-of-precipitation-underestimation
#18
Anna K Liljedahl, Larry D Hinzman, Douglas L Kane, Walter C Oechel, Craig E Tweedie, Donatella Zona
Difficulties in obtaining accurate precipitation measurements have limited meaningful hydrologic assessment for over a century due to performance challenges of conventional snowfall and rainfall gauges in windy environments. Here, we compare snowfall observations and bias adjusted snowfall to end-of-winter snow accumulation measurements on the ground for 16 years (1999-2014) and assess the implication of precipitation underestimation on the water balance for a low-gradient tundra wetland near Utqiagvik (formerly Barrow), Alaska (2007-2009)...
August 2017: Water Resources Research
https://www.readbyqxmd.com/read/29037401/out-on-a-limb-thermal-microenvironments-in-the-tropical-forest-canopy-and-their-relevance-to-ants
#19
Alyssa Y Stark, Benjamin J Adams, Jennifer L Fredley, Stephen P Yanoviak
Small, cursorial ectotherms like ants often are immersed in the superheated air layers that develop millimeters above exposed, insolated surfaces (i.e., the thermal boundary layer). We quantified the thermal microenvironments around tree branches in the tropical rainforest canopy, and explored the effects of substrate color on the internal body temperature and species composition of arboreal ants. Branch temperatures during the day (09:00-16:00) were hottest (often > 50°C) and most variable on the upper surface, while the lowest and least variable temperatures occurred on the underside...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28941624/the-biodistribution-and-pharmacokinetics-of-the-oxime-acetylcholinesterase-reactivator-rs194b-in-guinea-pigs
#20
Michael A Malfatti, Heather A Enright, Nicholas A Be, Edward A Kuhn, Saphon Hok, M Windy McNerney, Victoria Lao, Tuan H Nguyen, Felice C Lightstone, Timothy S Carpenter, Brian J Bennion, Carlos A Valdez
Organophosphorus-based (OP) nerve agents represent some of the most toxic substances known to mankind. The current standard of care for exposure has changed very little in the past decades, and relies on a combination of atropine to block receptor activity and oxime-type acetylcholinesterase (AChE) reactivators to reverse the OP binding to AChE. Although these oximes can block the effects of nerve agents, their overall efficacy is reduced by their limited capacity to cross the blood-brain barrier (BBB). RS194B, a new oxime developed by Radic et al...
November 1, 2017: Chemico-biological Interactions
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