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https://www.readbyqxmd.com/read/29415058/integration-of-neural-and-epigenetic-contributions-to-posttraumatic-stress-symptoms-the-role-of-hippocampal-volume-and-glucocorticoid-receptor-gene-methylation
#1
M Windy McNerney, Tong Sheng, Jordan M Nechvatal, Alex G Lee, David M Lyons, Salil Soman, Chun-Ping Liao, Ruth O'Hara, Joachim Hallmayer, Joy Taylor, J Wesson Ashford, Jerome Yesavage, Maheen M Adamson
Many Veterans exposed to physical and psychological trauma experience symptoms of posttraumatic stress disorder (PTSD). As the etiology of PTSD symptoms is complex, a better understanding of the underlying biological mechanisms may improve preventative care and treatment for PTSD. Recent findings from the fields of neuroimaging and epigenetics offer important insights into the potential brain structures and biochemical pathways of modified gene expression associated with PTSD. We combined neuroimaging and epigenetic measures to assess current PTSD symptoms by measuring overall hippocampal volume and methylation of the glucocorticoid receptor (GR) gene (promoter region)...
2018: PloS One
https://www.readbyqxmd.com/read/29378803/oral-manifestations-of-menopause-an-interprofessional-intervention-for-dental-hygiene-and-physician-assistant-students
#2
Windy L Rothmund, Ann D O'Kelley-Wetmore, Merri L Jones, Michael B Smith
Purpose: Interprofessional education (IPE) is a means of fostering integration and collaboration between health care professions. The purpose of this study was to evaluate the effect of an IPE educational module on dental hygiene (DH) and physician assistants (PA) students' knowledge of the oral manifestations of menopause and overall confidence in treating these conditions.Methods: A convenience sample of DH and PA students was used for this mixed-method study. Quantitative data was collected with pre- and post-tests using a modified Readiness for Interprofessional Learning Survey (RIPLS) and a principle investigator (PI)-designed knowledge of menopause test, to determine the students' attitudes and learning levels...
December 2017: Journal of Dental Hygiene: JDH
https://www.readbyqxmd.com/read/29358664/delayed-onset-of-autoreactive-antibody-production-and-m2-skewed-macrophages-contribute-to-improved-survival-of-taci-deficient-mrl-fas-lpr-mouse
#3
Lunhua Liu, Windy Rose Allman, Adam Steven Coleman, Kazuyo Takeda, Tsai-Lien Lin, Mustafa Akkoyunlu
Anti-B cell activating factor belonging to TNF-family (BAFF) antibody therapy is indicated for the treatment of patients with active systemic lupus erythematosus (SLE). We hypothesized that the BAFF receptor, transmembrane activator and calcium-modulator and cyclophilin interactor (TACI) may be responsible for the generation of antibody secreting plasma cells in SLE. To test this hypothesis, we generated TACI deficient MRL-Fas/Lpr (LPR-TACI-/-) mouse. TACI deficiency resulted in improved survival of MRL-Fas/Lpr mice and delayed production of anti-dsDNA and anti-SAM/RNP antibodies...
January 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29261719/improving-vehicle-tracking-rate-and-speed-estimation-in-dusty-and-snowy-weather-conditions-with-a-vibrating-camera
#4
Nastaran Yaghoobi Ershadi
Traffic surveillance systems are interesting to many researchers to improve the traffic control and reduce the risk caused by accidents. In this area, many published works are only concerned about vehicle detection in normal conditions. The camera may vibrate due to wind or bridge movement. Detection and tracking of vehicles is a very difficult task when we have bad weather conditions in winter (snowy, rainy, windy, etc.), dusty weather in arid and semi-arid regions, at night, etc. Also, it is very important to consider speed of vehicles in the complicated weather condition...
2017: PloS One
https://www.readbyqxmd.com/read/29204686/weather-conditions-influence-the-number-of-psychiatric-emergency-room-patients
#5
Eva Janina Brandl, Tristram A Lett, George Bakanidze, Andreas Heinz, Felix Bermpohl, Meryam Schouler-Ocak
The specific impact of weather factors on psychiatric disorders has been investigated only in few studies with inconsistent results. We hypothesized that meteorological conditions influence the number of cases presenting in a psychiatric emergency room as a measure of mental health conditions. We analyzed the number of patients consulting the emergency room (ER) of a psychiatric hospital in Berlin, Germany, between January 1, 2008, and December 31, 2014. A total of N = 22,672 cases were treated in the ER over the study period...
December 4, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29198307/a-bioequivalence-study-of-quetiapine-25-mg-film-coated-tablets-in-healthy-indonesian-subjects%C3%A2
#6
Yahdiana Harahap, Budi Prasaja, Windy Lusthom, Lia Yumi Yusvita, Theresia Sinandang, Hardiyanti
AIM: This study was conducted in order to compare the bioavailability of two film-coated tablets containing 25 mg of quetiapine. METHODS: 24 subjects were enrolled in and completed a single-center, randomized, single-dose, open-label, two-way crossover study with a 1-week washout period. Plasma samples were collected up to 24 hours following drug administration; thus, quetiapine was determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method with turbo-ion-spray mode...
November 30, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29156456/impact-of-truncated-area-on-point-estimate-and-intra-subject-variability-in-bioequivalence-of-dutasteride-with-long-half-life
#7
Budi Prasaja, Yahdiana Harahap, Windy Lusthom, Lia Yumi, Anna Sofiana, Monica Sandra, Falah Safira, Uci Chilmi
Purpose To investigate the effect of using truncated area under the curve (AUC0-72) on bioequivalence of dutasteride with long half-life in point estimate and intra-subject variability. Methods Fifteen subjects were enrolled in this single-dose, open-label, randomized two-way crossover design following an overnight fasting with five-week washout period. Plasma samples were collected to 72 h and 144 h following drug administration and dutasteride were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods...
November 20, 2017: Drug Research
https://www.readbyqxmd.com/read/29102776/assessing-disease-modifying-effects-of-norepinephrine-in-down-syndrome-and-alzheimer-s-disease
#8
Ravikumar Ponnusamy, M Windy McNerney, Shahrzad Moghadam, Ahmad Salehi
Building upon the knowledge that a number of important brain circuits undergo significant degeneration in Alzheimer's disease, numerous recent studies suggest that the norepinephrine-ergic system in the brainstem undergoes significant alterations early in the course of both Alzheimer's disease and Down syndrome. Massive projections from locus coeruleus neurons to almost the entire brain, extensive innervation of brain capillaries, and widespread distribution of noradrenergic receptors enable the norepinephrine-ergic system to play a crucial role in neural processes, including cognitive function...
November 8, 2017: Brain Research
https://www.readbyqxmd.com/read/29081549/tundra-water-budget-and-implications-of-precipitation-underestimation
#9
Anna K Liljedahl, Larry D Hinzman, Douglas L Kane, Walter C Oechel, Craig E Tweedie, Donatella Zona
Difficulties in obtaining accurate precipitation measurements have limited meaningful hydrologic assessment for over a century due to performance challenges of conventional snowfall and rainfall gauges in windy environments. Here, we compare snowfall observations and bias adjusted snowfall to end-of-winter snow accumulation measurements on the ground for 16 years (1999-2014) and assess the implication of precipitation underestimation on the water balance for a low-gradient tundra wetland near Utqiagvik (formerly Barrow), Alaska (2007-2009)...
August 2017: Water Resources Research
https://www.readbyqxmd.com/read/29037401/out-on-a-limb-thermal-microenvironments-in-the-tropical-forest-canopy-and-their-relevance-to-ants
#10
Alyssa Y Stark, Benjamin J Adams, Jennifer L Fredley, Stephen P Yanoviak
Small, cursorial ectotherms like ants often are immersed in the superheated air layers that develop millimeters above exposed, insolated surfaces (i.e., the thermal boundary layer). We quantified the thermal microenvironments around tree branches in the tropical rainforest canopy, and explored the effects of substrate color on the internal body temperature and species composition of arboreal ants. Branch temperatures during the day (09:00-16:00) were hottest (often > 50°C) and most variable on the upper surface, while the lowest and least variable temperatures occurred on the underside...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28941624/the-biodistribution-and-pharmacokinetics-of-the-oxime-acetylcholinesterase-reactivator-rs194b-in-guinea-pigs
#11
Michael A Malfatti, Heather A Enright, Nicholas A Be, Edward A Kuhn, Saphon Hok, M Windy McNerney, Victoria Lao, Tuan H Nguyen, Felice C Lightstone, Timothy S Carpenter, Brian J Bennion, Carlos A Valdez
Organophosphorus-based (OP) nerve agents represent some of the most toxic substances known to mankind. The current standard of care for exposure has changed very little in the past decades, and relies on a combination of atropine to block receptor activity and oxime-type acetylcholinesterase (AChE) reactivators to reverse the OP binding to AChE. Although these oximes can block the effects of nerve agents, their overall efficacy is reduced by their limited capacity to cross the blood-brain barrier (BBB). RS194B, a new oxime developed by Radic et al...
November 1, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28882026/epidemiology-and-risk-factors-of-voluntary-pesticide-poisoning-in-morocco-2008-2014
#12
Zineb Nabih, Latifa Amiar, Zakaria Abidli, Maria Windy, Abdelmajid Soulaymani, Abdelrhani Mokhtari, Rachida Soulaymani-Bencheikh
OBJECTIVES: To determine the epidemiological profile and risk factors of voluntary poisoning by pesticides. METHODS: A retrospective analysis was conducted of all cases of voluntary poisoning by pesticides registered at the AntiPoison and Pharmacovigilance Center of Morocco between January 2008 and December 2014. RESULTS: During the study period, 2,690 cases of acute pesticide poisoning were registered. The region of Rabat-Salé-Zemmour-Zaer accounted for the largest proportion, with 598 cases...
2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28865495/repetitive-transcranial-magnetic-stimulation-rtms-for-treatment-resistant-major-depression-trmd-veteran-patients-study-protocol-for-a-randomized-controlled-trial
#13
Zhibao Mi, Kousick Biswas, J Kaci Fairchild, Anne Davis-Karim, Ciaran S Phibbs, Steven D Forman, Michael Thase, Gerald Georgette, Tamara Beale, David Pittman, Margaret Windy McNerney, Allyson Rosen, Grant D Huang, Mark George, Art Noda, Jerome A Yesavage
BACKGROUND: Evaluation of repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant major depression (TRMD) in Veterans offers unique clinical trial challenges. Here we describe a randomized, double-blinded, intent-to-treat, two-arm, superiority parallel design, a multicenter study funded by the Cooperative Studies Program (CSP No. 556) of the US Department of Veterans Affairs. METHODS: We recruited medical providers with clinical expertise in treating TRMD at nine Veterans Affairs (VA) medical centers as the trial local investigators...
September 2, 2017: Trials
https://www.readbyqxmd.com/read/28829633/a-breath-of-fresh-air-in-foraging-theory-the-importance-of-wind-for-food-size-selection-in-a-central-place-forager
#14
Andrea Marina Alma, Alejandro G Farji-Brener, Luciana Elizalde
Empirical data about food size carried by central-place foragers do not often fit with the optimum predicted by classical foraging theory. Traditionally, biotic constraints such as predation risk and competition have been proposed to explain this inconsistency, leaving aside the possible role of abiotic factors. Here we documented how wind affects the load size of a central-place forager (leaf-cutting ants) through a mathematical model including the whole foraging process. The model showed that as wind speed at ground level increased from 0 to 2 km/h, load size decreased from 91 to 30 mm(2), a prediction that agreed with empirical data from windy zones, highlighting the relevance of considering abiotic factors to predict foraging behavior...
September 2017: American Naturalist
https://www.readbyqxmd.com/read/28826610/calling-chromosome-alterations-dna-methylation-statuses-and-mutations-in-tumors-by-simple-targeted-next-generation-sequencing-a-solution-for-transferring-integrated-pangenomic-studies-into-routine-practice
#15
Simon Garinet, Mario Néou, Bruno de La Villéon, Simon Faillot, Julien Sakat, Juliana P Da Fonseca, Anne Jouinot, Christophe Le Tourneau, Maud Kamal, Windy Luscap-Rondof, Valentina Boeva, Sebastien Gaujoux, Michel Vidaud, Eric Pasmant, Franck Letourneur, Jérôme Bertherat, Guillaume Assié
Pangenomic studies identified distinct molecular classes for many cancers, with major clinical applications. However, routine use requires cost-effective assays. We assessed whether targeted next-generation sequencing (NGS) could call chromosomal alterations and DNA methylation status. A training set of 77 tumors and a validation set of 449 (43 tumor types) were analyzed by targeted NGS and single-nucleotide polymorphism (SNP) arrays. Thirty-two tumors were analyzed by NGS after bisulfite conversion, and compared to methylation array or methylation-specific multiplex ligation-dependent probe amplification...
September 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28725374/snowbeds-are-more-affected-than-other-subalpine-alpine-plant-communities-by-climate-change-in-the-swiss-alps
#16
Magalì Matteodo, Klaus Ammann, Eric Pascal Verrecchia, Pascal Vittoz
While the upward shift of plant species has been observed on many alpine and nival summits, the reaction of the subalpine and lower alpine plant communities to the current warming and lower snow precipitation has been little investigated so far. To this aim, 63 old, exhaustive plant inventories, distributed along a subalpine-alpine elevation gradient of the Swiss Alps and covering different plant community types (acidic and calcareous grasslands; windy ridges; snowbeds), were revisited after 25-50 years. Old and recent inventories were compared in terms of species diversity with Simpson diversity and Bray-Curtis dissimilarity indices, and in terms of community composition with principal component analysis...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28724246/health-consequences-of-electric-lighting-practices-in-the-modern-world-a-report-on-the-national-toxicology-program-s-workshop-on-shift-work-at-night-artificial-light-at-night-and-circadian-disruption
#17
REVIEW
Ruth M Lunn, David E Blask, Andrew N Coogan, Mariana G Figueiro, Michael R Gorman, Janet E Hall, Johnni Hansen, Randy J Nelson, Satchidananda Panda, Michael H Smolensky, Richard G Stevens, Fred W Turek, Roel Vermeulen, Tania Carreón, Claire C Caruso, Christina C Lawson, Kristina A Thayer, Michael J Twery, Andrew D Ewens, Sanford C Garner, Pamela J Schwingl, Windy A Boyd
The invention of electric light has facilitated a society in which people work, sleep, eat, and play at all hours of the 24-hour day. Although electric light clearly has benefited humankind, exposures to electric light, especially light at night (LAN), may disrupt sleep and biological processes controlled by endogenous circadian clocks, potentially resulting in adverse health outcomes. Many of the studies evaluating adverse health effects have been conducted among night- and rotating-shift workers, because this scenario gives rise to significant exposure to LAN...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28711661/mechanisms-of-action-and-clinical-efficacy-of-nmda-receptor-modulators-in-mood-disorders
#18
REVIEW
Mehdi Ghasemi, Cristy Phillips, Atoossa Fahimi, Margaret Windy McNerney, Ahmad Salehi
Although the biogenic amine models have provided meaningful links between clinical phenomena and pharmacological management of mood disorders (MDs), the onset of action of current treatments is slow and a proportion of individuals fail to adequately respond. A growing number of investigations have focused on the glutamatergic system as a viable target. Herein we review the putative role of N-methyl-d-aspartate (NMDA) signaling in the pathophysiology of MDs. Prompting this focus are several lines of evidence: 1) altered glutamate and NMDA receptor (NMDAR) expression and functioning; 2) antidepressant effects of NMDAR signaling blockers; 3) interaction between conventional therapeutic regimens and NMDAR signaling modulators; 4) biochemical evidence of interaction between monoaminergic system and NMDAR signaling; 5) interaction between neurotrophic factors and NMDAR signaling in mood regulation; 6) cross-talk between NMDAR signaling and inflammatory processes; and 7) antidepressant effects of a number of NMDA modulators in recent clinical trials...
July 13, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28699730/flexible-slippery-surface-to-manipulate-droplet-coalescence-and-sliding-and-its-practicability-in-wind-resistant-water-collection
#19
Yuanfeng Wang, Baitai Qian, Chuilin Lai, Xiaowen Wang, Kaikai Ma, Yujuan Guo, Xingli Zhu, Bin Fei, John H Xin
A flexible slippery membrane (FSM) with tunable morphology and high elastic deformability has been developed by infusing perfluoropolyether (PFPE) into a fluorinated-copolymer-modified thermoplastic polyurethane (TPU) nanofiberous membrane. To immobilize PFPE in TPU matrix, we synthesized a fluorinated-copolymer poly(DFMA-co-IBOA-co-LMA) with low surface energy, high chemical affinity to PFPE, adequate flexibility, and strong physical adhesion on TPU. Upon external tensile stress, the as-prepared FSM can realize a real-time manipulation of water sliding and coalescence on it...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28637726/interventions-for-preventing-mother-to-child-hiv-transmission-protocol-of-an-overview-of-systematic-reviews
#20
Windy Mariane Virenia Wariki, Erika Ota, Rintaro Mori, Charles S Wiysonge, Hacsi Horvath, Jennifer S Read
INTRODUCTION: Various interventions to prevent mother-to-child-transmission (MTCT) of HIV have been investigated and implemented. A number of systematic reviews assessing the efficacy of interventions for the prevention of MTCT of HIV reported antiretroviral prophylaxis, caesarean section before labour and before ruptured membranes, and complete avoidance of breastfeeding were efficacious for preventing MTCT of HIV. Recent WHO guidelines recommend lifelong antiretroviral therapy for all pregnant women for treatment of the woman's own HIV infection and for prevention of MTCT of HIV...
June 21, 2017: BMJ Open
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