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https://www.readbyqxmd.com/read/29204686/weather-conditions-influence-the-number-of-psychiatric-emergency-room-patients
#1
Eva Janina Brandl, Tristram A Lett, George Bakanidze, Andreas Heinz, Felix Bermpohl, Meryam Schouler-Ocak
The specific impact of weather factors on psychiatric disorders has been investigated only in few studies with inconsistent results. We hypothesized that meteorological conditions influence the number of cases presenting in a psychiatric emergency room as a measure of mental health conditions. We analyzed the number of patients consulting the emergency room (ER) of a psychiatric hospital in Berlin, Germany, between January 1, 2008, and December 31, 2014. A total of N = 22,672 cases were treated in the ER over the study period...
December 4, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29198307/a-bioequivalence-study-of-quetiapine-25-mg-film-coated-tablets-in-healthy-indonesian-subjects%C3%A2
#2
Yahdiana Harahap, Budi Prasaja, Windy Lusthom, Lia Yumi Yusvita, Theresia Sinandang, Hardiyanti
AIM: This study was conducted in order to compare the bioavailability of two film-coated tablets containing 25 mg of quetiapine. METHODS: 24 subjects were enrolled in and completed a single-center, randomized, single-dose, open-label, two-way crossover study with a 1-week washout period. Plasma samples were collected up to 24 hours following drug administration; thus, quetiapine was determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method with turbo-ion-spray mode...
November 30, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29156456/impact-of-truncated-area-on-point-estimate-and-intra-subject-variability-in-bioequivalence-of-dutasteride-with-long-half-life
#3
Budi Prasaja, Yahdiana Harahap, Windy Lusthom, Lia Yumi, Anna Sofiana, Monica Sandra, Falah Safira, Uci Chilmi
Purpose To investigate the effect of using truncated area under the curve (AUC0-72) on bioequivalence of dutasteride with long half-life in point estimate and intra-subject variability. Methods Fifteen subjects were enrolled in this single-dose, open-label, randomized two-way crossover design following an overnight fasting with five-week washout period. Plasma samples were collected to 72 h and 144 h following drug administration and dutasteride were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods...
November 20, 2017: Drug Research
https://www.readbyqxmd.com/read/29102776/assessing-disease-modifying-effects-of-norepinephrine-in-down-syndrome-and-alzheimer-s-disease
#4
Ravikumar Ponnusamy, M Windy McNerney, Shahrzad Moghadam, Ahmad Salehi
Building upon the knowledge that a number of important brain circuits undergo significant degeneration in Alzheimer's disease, numerous recent studies suggest that the norepinephrine-ergic system in the brainstem undergoes significant alterations early in the course of both Alzheimer's disease and Down syndrome. Massive projections from locus coeruleus neurons to almost the entire brain, extensive innervation of brain capillaries, and widespread distribution of noradrenergic receptors enable the norepinephrine-ergic system to play a crucial role in neural processes, including cognitive function...
November 8, 2017: Brain Research
https://www.readbyqxmd.com/read/29081549/tundra-water-budget-and-implications-of-precipitation-underestimation
#5
Anna K Liljedahl, Larry D Hinzman, Douglas L Kane, Walter C Oechel, Craig E Tweedie, Donatella Zona
Difficulties in obtaining accurate precipitation measurements have limited meaningful hydrologic assessment for over a century due to performance challenges of conventional snowfall and rainfall gauges in windy environments. Here, we compare snowfall observations and bias adjusted snowfall to end-of-winter snow accumulation measurements on the ground for 16 years (1999-2014) and assess the implication of precipitation underestimation on the water balance for a low-gradient tundra wetland near Utqiagvik (formerly Barrow), Alaska (2007-2009)...
August 2017: Water Resources Research
https://www.readbyqxmd.com/read/29037401/out-on-a-limb-thermal-microenvironments-in-the-tropical-forest-canopy-and-their-relevance-to-ants
#6
Alyssa Y Stark, Benjamin J Adams, Jennifer L Fredley, Stephen P Yanoviak
Small, cursorial ectotherms like ants often are immersed in the superheated air layers that develop millimeters above exposed, insolated surfaces (i.e., the thermal boundary layer). We quantified the thermal microenvironments around tree branches in the tropical rainforest canopy, and explored the effects of substrate color on the internal body temperature and species composition of arboreal ants. Branch temperatures during the day (09:00-16:00) were hottest (often > 50°C) and most variable on the upper surface, while the lowest and least variable temperatures occurred on the underside...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28941624/the-biodistribution-and-pharmacokinetics-of-the-oxime-acetylcholinesterase-reactivator-rs194b-in-guinea-pigs
#7
Michael A Malfatti, Heather A Enright, Nicholas A Be, Edward A Kuhn, Saphon Hok, M Windy McNerney, Victoria Lao, Tuan H Nguyen, Felice C Lightstone, Timothy S Carpenter, Brian J Bennion, Carlos A Valdez
Organophosphorus-based (OP) nerve agents represent some of the most toxic substances known to mankind. The current standard of care for exposure has changed very little in the past decades, and relies on a combination of atropine to block receptor activity and oxime-type acetylcholinesterase (AChE) reactivators to reverse the OP binding to AChE. Although these oximes can block the effects of nerve agents, their overall efficacy is reduced by their limited capacity to cross the blood-brain barrier (BBB). RS194B, a new oxime developed by Radic et al...
November 1, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28882026/epidemiology-and-risk-factors-of-voluntary-pesticide-poisoning-in-morocco-2008-2014
#8
Zineb Nabih, Latifa Amiar, Zakaria Abidli, Maria Windy, Abdelmajid Soulaymani, Abdelrhani Mokhtari, Rachida Soulaymani-Bencheikh
OBJECTIVES: To determine the epidemiological profile and risk factors of voluntary poisoning by pesticides. METHODS: A retrospective analysis was conducted of all cases of voluntary poisoning by pesticides registered at the AntiPoison and Pharmacovigilance Center of Morocco between January 2008 and December 2014. RESULTS: During the study period, 2,690 cases of acute pesticide poisoning were registered. The region of Rabat-Salé-Zemmour-Zaer accounted for the largest proportion, with 598 cases...
2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28865495/repetitive-transcranial-magnetic-stimulation-rtms-for-treatment-resistant-major-depression-trmd-veteran-patients-study-protocol-for-a-randomized-controlled-trial
#9
Zhibao Mi, Kousick Biswas, J Kaci Fairchild, Anne Davis-Karim, Ciaran S Phibbs, Steven D Forman, Michael Thase, Gerald Georgette, Tamara Beale, David Pittman, Margaret Windy McNerney, Allyson Rosen, Grant D Huang, Mark George, Art Noda, Jerome A Yesavage
BACKGROUND: Evaluation of repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant major depression (TRMD) in Veterans offers unique clinical trial challenges. Here we describe a randomized, double-blinded, intent-to-treat, two-arm, superiority parallel design, a multicenter study funded by the Cooperative Studies Program (CSP No. 556) of the US Department of Veterans Affairs. METHODS: We recruited medical providers with clinical expertise in treating TRMD at nine Veterans Affairs (VA) medical centers as the trial local investigators...
September 2, 2017: Trials
https://www.readbyqxmd.com/read/28829633/a-breath-of-fresh-air-in-foraging-theory-the-importance-of-wind-for-food-size-selection-in-a-central-place-forager
#10
Andrea Marina Alma, Alejandro G Farji-Brener, Luciana Elizalde
Empirical data about food size carried by central-place foragers do not often fit with the optimum predicted by classical foraging theory. Traditionally, biotic constraints such as predation risk and competition have been proposed to explain this inconsistency, leaving aside the possible role of abiotic factors. Here we documented how wind affects the load size of a central-place forager (leaf-cutting ants) through a mathematical model including the whole foraging process. The model showed that as wind speed at ground level increased from 0 to 2 km/h, load size decreased from 91 to 30 mm(2), a prediction that agreed with empirical data from windy zones, highlighting the relevance of considering abiotic factors to predict foraging behavior...
September 2017: American Naturalist
https://www.readbyqxmd.com/read/28826610/calling-chromosome-alterations-dna-methylation-statuses-and-mutations-in-tumors-by-simple-targeted-next-generation-sequencing-a-solution-for-transferring-integrated-pangenomic-studies-into-routine-practice
#11
Simon Garinet, Mario Néou, Bruno de La Villéon, Simon Faillot, Julien Sakat, Juliana P Da Fonseca, Anne Jouinot, Christophe Le Tourneau, Maud Kamal, Windy Luscap-Rondof, Valentina Boeva, Sebastien Gaujoux, Michel Vidaud, Eric Pasmant, Franck Letourneur, Jérôme Bertherat, Guillaume Assié
Pangenomic studies identified distinct molecular classes for many cancers, with major clinical applications. However, routine use requires cost-effective assays. We assessed whether targeted next-generation sequencing (NGS) could call chromosomal alterations and DNA methylation status. A training set of 77 tumors and a validation set of 449 (43 tumor types) were analyzed by targeted NGS and single-nucleotide polymorphism (SNP) arrays. Thirty-two tumors were analyzed by NGS after bisulfite conversion, and compared to methylation array or methylation-specific multiplex ligation-dependent probe amplification...
September 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28725374/snowbeds-are-more-affected-than-other-subalpine-alpine-plant-communities-by-climate-change-in-the-swiss-alps
#12
Magalì Matteodo, Klaus Ammann, Eric Pascal Verrecchia, Pascal Vittoz
While the upward shift of plant species has been observed on many alpine and nival summits, the reaction of the subalpine and lower alpine plant communities to the current warming and lower snow precipitation has been little investigated so far. To this aim, 63 old, exhaustive plant inventories, distributed along a subalpine-alpine elevation gradient of the Swiss Alps and covering different plant community types (acidic and calcareous grasslands; windy ridges; snowbeds), were revisited after 25-50 years. Old and recent inventories were compared in terms of species diversity with Simpson diversity and Bray-Curtis dissimilarity indices, and in terms of community composition with principal component analysis...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28724246/health-consequences-of-electric-lighting-practices-in-the-modern-world-a-report-on-the-national-toxicology-program-s-workshop-on-shift-work-at-night-artificial-light-at-night-and-circadian-disruption
#13
REVIEW
Ruth M Lunn, David E Blask, Andrew N Coogan, Mariana G Figueiro, Michael R Gorman, Janet E Hall, Johnni Hansen, Randy J Nelson, Satchidananda Panda, Michael H Smolensky, Richard G Stevens, Fred W Turek, Roel Vermeulen, Tania Carreón, Claire C Caruso, Christina C Lawson, Kristina A Thayer, Michael J Twery, Andrew D Ewens, Sanford C Garner, Pamela J Schwingl, Windy A Boyd
The invention of electric light has facilitated a society in which people work, sleep, eat, and play at all hours of the 24-hour day. Although electric light clearly has benefited humankind, exposures to electric light, especially light at night (LAN), may disrupt sleep and biological processes controlled by endogenous circadian clocks, potentially resulting in adverse health outcomes. Many of the studies evaluating adverse health effects have been conducted among night- and rotating-shift workers, because this scenario gives rise to significant exposure to LAN...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28711661/mechanisms-of-action-and-clinical-efficacy-of-nmda-receptor-modulators-in-mood-disorders
#14
REVIEW
Mehdi Ghasemi, Cristy Phillips, Atoossa Fahimi, Margaret Windy McNerney, Ahmad Salehi
Although the biogenic amine models have provided meaningful links between clinical phenomena and pharmacological management of mood disorders (MDs), the onset of action of current treatments is slow and a proportion of individuals fail to adequately respond. A growing number of investigations have focused on the glutamatergic system as a viable target. Herein we review the putative role of N-methyl-d-aspartate (NMDA) signaling in the pathophysiology of MDs. Prompting this focus are several lines of evidence: 1) altered glutamate and NMDA receptor (NMDAR) expression and functioning; 2) antidepressant effects of NMDAR signaling blockers; 3) interaction between conventional therapeutic regimens and NMDAR signaling modulators; 4) biochemical evidence of interaction between monoaminergic system and NMDAR signaling; 5) interaction between neurotrophic factors and NMDAR signaling in mood regulation; 6) cross-talk between NMDAR signaling and inflammatory processes; and 7) antidepressant effects of a number of NMDA modulators in recent clinical trials...
July 13, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28699730/flexible-slippery-surface-to-manipulate-droplet-coalescence-and-sliding-and-its-practicability-in-wind-resistant-water-collection
#15
Yuanfeng Wang, Baitai Qian, Chuilin Lai, Xiaowen Wang, Kaikai Ma, Yujuan Guo, Xingli Zhu, Bin Fei, John H Xin
A flexible slippery membrane (FSM) with tunable morphology and high elastic deformability has been developed by infusing perfluoropolyether (PFPE) into a fluorinated-copolymer-modified thermoplastic polyurethane (TPU) nanofiberous membrane. To immobilize PFPE in TPU matrix, we synthesized a fluorinated-copolymer poly(DFMA-co-IBOA-co-LMA) with low surface energy, high chemical affinity to PFPE, adequate flexibility, and strong physical adhesion on TPU. Upon external tensile stress, the as-prepared FSM can realize a real-time manipulation of water sliding and coalescence on it...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28637726/interventions-for-preventing-mother-to-child-hiv-transmission-protocol-of-an-overview-of-systematic-reviews
#16
Windy Mariane Virenia Wariki, Erika Ota, Rintaro Mori, Charles S Wiysonge, Hacsi Horvath, Jennifer S Read
INTRODUCTION: Various interventions to prevent mother-to-child-transmission (MTCT) of HIV have been investigated and implemented. A number of systematic reviews assessing the efficacy of interventions for the prevention of MTCT of HIV reported antiretroviral prophylaxis, caesarean section before labour and before ruptured membranes, and complete avoidance of breastfeeding were efficacious for preventing MTCT of HIV. Recent WHO guidelines recommend lifelong antiretroviral therapy for all pregnant women for treatment of the woman's own HIV infection and for prevention of MTCT of HIV...
June 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28595122/winds-and-the-distribution-of-nearshore-phytoplankton-in-a-stratified-lake
#17
Hélène Cyr
The distribution of phytoplankton in lakes is notoriously patchy and dynamic, but wind-driven currents and algal buoyancy/motility are thought to determine where algae accumulate. In this study, nearshore phytoplankton were sampled from different parts of a lake basin twice a day for 4-5 consecutive days, in the spring and in late summer, to test whether short-term changes in phytoplankton biomass and community composition can be predicted from wind-driven currents. On windy days, phytoplankton biomass was higher at downwind than at upwind nearshore sites, and the magnitude of this difference increased linearly with increasing wind speed...
October 1, 2017: Water Research
https://www.readbyqxmd.com/read/28580677/lgbtq-youth-s-views-on-gay-straight-alliances-building-community-providing-gateways-and-representing-safety-and-support
#18
Carolyn M Porta, Erin Singer, Christopher J Mehus, Amy L Gower, Elizabeth Saewyc, Windy Fredkove, Marla E Eisenberg
BACKGROUND: Gay-Straight Alliances (GSAs) are school-based clubs that can contribute to a healthy school climate for lesbian, gay, bisexual, transgender, and questioning (LGBTQ) youth. While positive associations between health behaviors and GSAs have been documented, less is known about how youth perceive GSAs. METHODS: A total of 58 LGBTQ youth (14-19 years old) mentioned GSAs during go-along interviews in 3 states/provinces in North America. These 446 comments about GSAs were thematically coded and organized using Atlas...
July 2017: Journal of School Health
https://www.readbyqxmd.com/read/28510626/outcome-measures-for-clinical-trials-of-leber-congenital-amaurosis-caused-by-the-intronic-mutation-in-the-cep290-gene
#19
Samuel G Jacobson, Artur V Cideciyan, Alexander Sumaroka, Alejandro J Roman, Jason Charng, Monica Lu, Windy Choi, Rebecca Sheplock, Malgorzata Swider, Mychajlo S Kosyk, Sharon B Schwartz, Edwin M Stone, Gerald A Fishman
Purpose: To determine efficacy outcome measures for clinical trials of Leber congenital amaurosis (LCA) associated with a common intronic mutation in the CEP290 gene. Methods: CEP290-LCA patients (ages 5-48) with the intronic mutation (c.2991+1655A>G) were studied as a retrospective observational case series using clinical methods and with full-field sensitivity testing (FST), optical coherence tomography (OCT), autofluorescence imaging (NIR-RAFI), transient pupillary light reflex (TPLR), oculomotor control and instability (OCI), a mobility course, and a questionnaire (NEI-VFQ)...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28497171/measuring-facial-cooling-in-outdoor-windy-winter-conditions-an-exploratory-study
#20
Andrew G S Briggs, Terry J Gillespie, Robert D Brown
Winter clothing provides insulation for almost all of a person's body, but in most situations, a person's face remains uncovered even in cold windy weather. This exploratory study used thermal imagery to record the rate of cooling of the faces of volunteers in a range of winter air temperatures and wind speeds. Different areas of the faces cooled at different rates with the areas around the eyes and neck cooling at the slowest rate, and the nose and cheeks cooling at the fastest rate. In all cases, the faces cooled at an approximately logarithmic decay for the first few minutes...
October 2017: International Journal of Biometeorology
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