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Subarachnoid haemorrhage

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https://www.readbyqxmd.com/read/28436243/comparison-of-the-timing-of-intervention-and-treatment-modality-of-poor-grade-aneurysmal-subarachnoid-hemorrhage
#1
Tomasz Tykocki, Marcin Czyż, Małgorzata Machaj, Dorota Szydlarska, Bogusław Kostkiewicz
OBJECTIVES: The timing and modality of intervention in the treatment of poor-grade aneurysmal subarachnoid haemorrhage (aSAH) has not been defined. The purpose of the study is to analyse whether early treatment and type of intervention influence the clinical outcomes of poor-grade aSAH patients. MATERIAL AND METHODS: Patients with poor-grade aSAH were retrieved. Demographics, Fisher grade, radiological characteristics and clinical outcomes were recorded. Outcomes were compared using the modified Rankin Scale (mRS), for groups treated early within 24 hours of aSAH or later and by clipping or endovascular therapy...
April 24, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28430870/potential-mechanisms-of-white-matter-injury-in-the-acute-phase-of-experimental-subarachnoid-haemorrhage
#2
Yue Wu, Jianhua Peng, Jinwei Pang, Xiaochuan Sun, Yong Jiang
No abstract text is available yet for this article.
April 18, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28421822/deflation-of-a-rathke-cleft-cyst-triggered-rupture-of-a-superior-hypophyseal-artery-aneurysm-a-case-report
#3
Ryuheki Kitai, Takahiro Yamauchi, Yoshikazu Arai, Tetsuya Hosoda, Norichika Hashimoto, Kenzo Tsunetoshi, Yoshifumi Higashino, Ken-Ichiro Kikuta
A 57-year-old woman was diagnosed as a Rathke cleft cyst (RCC). Endoscopic transsphenoidal surgery (TSS) was performed uneventfully. She developed subarachnoid haemorrhage on postoperative day 3. The vessels adhered the cyst had been pulled into the pituitary fossa, causing an aneurysm.
April 19, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28420192/thioredoxin-interacting-protein-mediates-apoptosis-in-early-brain-injury-after-subarachnoid-haemorrhage
#4
Qing Zhao, Xudong Che, Hongxia Zhang, Guanping Tan, Liu Liu, Dengzhi Jiang, Jun Zhao, Xiang Xiang, Xiaochuan Sun, Zhaohui He
Early brain injury (EBI) is considered to be the major factor associated with high morbidity and mortality after subarachnoid haemorrhage (SAH). Apoptosis is the major pathological mechanism of EBI, and its pathogenesis has not been fully clarified. Here, we report that thioredoxin-interacting protein (TXNIP), which is induced by protein kinase RNA-like endoplasmic reticulum (ER) kinase (PERK), participates in EBI by promoting apoptosis. By using adult male Sprague-Dawley rats to establish SAH models, as well as Terminal dexynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) staining, immunofluorescence, and western blot, we found that TXNIP expression significantly increased after SAH in comparison to the sham group and peaked at 48 h (up to 3...
April 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28417961/high-throughput-sequencing-and-co-expression-network-analysis-of-lncrnas-and-mrnas-in-early-brain-injury-following-experimental-subarachnoid-haemorrhage
#5
Jianhua Peng, Yue Wu, Xiaocui Tian, Jinwei Pang, Li Kuai, Fang Cao, Xinghu Qin, Jianjun Zhong, Xinshen Li, Yong Li, Xiaochuan Sun, Ligang Chen, Yong Jiang
Subarachnoid haemorrhage (SAH) is a fatal neurovascular disease following cerebral aneurysm rupture with high morbidity and mortality rates. Long non-coding RNAs (lncRNAs) are a type of mammalian genome transcript, are abundantly expressed in the brain and are involved in many nervous system diseases. However, little is currently known regarding the influence of lncRNAs in early brain injury (EBI) after SAH. This study analysed the expression profiles of lncRNAs and mRNAs in SAH brain tissues of mice using high-throughput sequencing...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28376710/electrocardiographic-changes-mimicking-acute-coronary-syndrome-in-a-large-intracranial-tumour-a-diagnostic-dilemma
#6
Nilukshana Yogendranathan, H M M T B Herath, S P Pahalagamage, Aruna Kulatunga
BACKGROUND: ST elevation Myocardial infarction is a medical emergency. A variety of noncardiac conditions had been known to mimic the ECG changes that are seen in acute coronary syndrome. Although the common ECG changes that are documented with raised intracranial pressure are T inversions, prolongation of QT interval and sinus bradycardia, ST elevation or depression, arrhythmias and prominent U waves have also been recognized. However, ST elevations in association with primary intracranial tumours are rarely reported...
April 4, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28373180/cortical-subarachnoid-haemorrhage-with-reversible-cerebral-vasoconstriction-syndrome-in-an-elderly-woman
#7
Yoshihiko Chiba, Daisuke Yamamoto, Tsuyoshi Uchiyama
No abstract text is available yet for this article.
April 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28360241/protocol-for-validating-cardiovascular-and-cerebrovascular-icd-9-cm-codes-in-healthcare-administrative-databases-the-umbria-data-value-project
#8
Francesco Cozzolino, Iosief Abraha, Massimiliano Orso, Anna Mengoni, Maria Francesca Cerasa, Paolo Eusebi, Giuseppe Ambrosio, Alessandro Montedori
INTRODUCTION: Administrative healthcare databases can provide a comprehensive assessment of the burden of diseases in terms of major outcomes, such as mortality, hospital readmissions and use of healthcare resources, thus providing answers to a wide spectrum of research questions. However, a crucial issue is the reliability of information gathered. Aim of this protocol is to validate International Classification of Diseases, 9th Revision-Clinical Modification (ICD-9-CM) codes for major cardiovascular diseases, including acute myocardial infarction (AMI), heart failure (HF), atrial fibrillation (AF) and stroke...
March 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28353468/primary-budd-chiari-syndrome-in-children-king-s-college-hospital-experience
#9
Susana Nobre, Rajeev Khanna, Natalie Bab, Eirini Kyrana, Sue Height, John Karani, Pauline Kane, Nigel Heaton, Anil Dhawan
Primary Budd-Chiari syndrome (BCS) is a rare cause of liver disease in children in the western world. Here we present a retrospective review of children with Primary BCS presenting from Jan 2001 to Nov 2015 to our hospital. Seven children were identified. Their presentation was mostly chronic. All had predisposing factors for thrombosis and were started on anticoagulation. Radiological interventions (2 transjugular intrahepatic portosystemic shunts (TIPSS) and 1 hepatic vein stenting), liver transplant and mesocaval shunt were done in 3, 2 and 1 patients, respectively; one child underwent bone-marrow transplantation following TIPSS, and one child was managed only medically...
March 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28335640/nebivolol-attenuates-cerebral-vasospasm-both-by-increasing-endothelial-nitric-oxide-and-by-decreasing-oxidative-stress-in-an-experimental-subarachnoid-haemorrhage
#10
Mehmet Arif Aladag, Yusuf Turkoz, Hakan Parlakpinar, Mehmet Gul
OBJECTIVE: Evidence suggests that reduction of nitric oxide (NO) bioavailability due to oxidative stress plays a central role in the pathophysiology of cerebral vasospasm after subarachnoid haemorrhage (SAH). To prevent SAH-induced cerebral vasospasm, therefore we used nebivolol hydrochloride as a NO-mediated vasodilator and an antioxidant drug in an experimental rat model of SAH. MATERIALS AND METHODS: Forty female Wistar rats were divided into control, SAH, SAH plus placebo, and SAH plus nebivolol groups...
March 23, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28331015/association-between-clinically-recorded-alcohol-consumption-and-initial-presentation-of-12-cardiovascular-diseases-population-based-cohort-study-using-linked-health-records
#11
Steven Bell, Marina Daskalopoulou, Eleni Rapsomaniki, Julie George, Annie Britton, Martin Bobak, Juan P Casas, Caroline E Dale, Spiros Denaxas, Anoop D Shah, Harry Hemingway
Objectives To investigate the association between alcohol consumption and cardiovascular disease at higher resolution by examining the initial lifetime presentation of 12 cardiac, cerebrovascular, abdominal, or peripheral vascular diseases among five categories of consumption.Design Population based cohort study of linked electronic health records covering primary care, hospital admissions, and mortality in 1997-2010 (median follow-up six years).Setting CALIBER (ClinicAl research using LInked Bespoke studies and Electronic health Records)...
March 22, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28323187/activation-of-cytotoxic-natural-killer-cells-after-aneurysmal-subarachnoid-haemorrhage
#12
Daniel Spitzer, Nina Johanna Spitzer, Monika Deininger, Christian Rainer Wirtz, Ralph König, Timo Burster, Thomas Kapapa
OBJECTIVE: Cell-mediated inflammation is critical in development of cerebrovascular complications after aneurysmal subarachnoid haemorrhage (aSAH). We analysed the course for activated CD16(bright)CD56(dim) cytotoxic NKCSF cells (NK) in cerebrospinal fluid (CSF) of 15 patients. METHODS: Patients were classified by occurrence of cerebral vasospasm and delayed cerebral ischemia. NK were monitored by flow cytometry between day 1 and 14 after haemorrhage. RESULTS: 12 (80%) patients developed CV with a mean day of detection at 3...
March 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28322094/diabetes-mellitus-and-the-risk-of-aneurysmal-subarachnoid-haemorrhage-a-systematic-review-and-meta-analysis-of-current-evidence
#13
Xi-Yang Yao, Cai-Qi Jiang, Gen-Lai Jia, Gang Chen
Objective This systematic review aimed to define the relationship between diabetes mellitus (DM) and the risk of aneurysmal subarachnoid haemorrhage (aSAH). Methods Studies associated with DM and aSAH published until March 2016 were retrieved from Pubmed, Embase, Web of Science, and Cochrane Library databases. A random-effects model was used to calculate the relative risks (RRs) with 95% confidence intervals (CIs). Results Eighteen observational studies were retrieved. The overall RRs for DM and aSAH were RRs = 0...
December 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/28289516/biochemical-changes-in-the-injured-brain
#14
EDITORIAL
Seelora Sahu, Deb Sanjay Nag, Amlan Swain, Devi Prasad Samaddar
Brain metabolism is an energy intensive phenomenon involving a wide spectrum of chemical intermediaries. Various injury states have a detrimental effect on the biochemical processes involved in the homeostatic and electrophysiological properties of the brain. The biochemical markers of brain injury are a recent addition in the armamentarium of neuro-clinicians and are being increasingly used in the routine management of neuro-pathological entities such as traumatic brain injury, stroke, subarachnoid haemorrhage and intracranial space occupying lesions...
February 26, 2017: World Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28283187/successful-delayed-coiling-of-a-ruptured-growing-distal-posterior-cerebral-artery-mycotic-aneurysm
#15
C Champeaux, N Walker, J Derwin, A Grivas
Intracranial infectious aneurysm (IIA) is a rare form of cerebrovascular malformation for which obliteration may be undertaken after rupture or non-response to targeted antibiotic therapy. We discuss the case of a 19-year-old man who presented with acute neurologic decline (Glasgow Coma Scale of 8) and endocarditis. CT images demonstrated subarachnoid haemorrhage, hydrocephalus and a mycotic aneurysm on the left posterior cerebral artery. Conservative management was initially decided due to the high risk of stroke and hemianopia...
March 7, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28283001/cranial-subarachnoid-and-subdural-haemorrhage-caused-by-spinal-melanoma-metastasis
#16
Farouk Olubajo, Stavros Stavropoulos, M Masood Hussain, Chris Rowland-Hill, Shailendra Achawal
A 73-year-old female with a history of metastatic melanoma presented with extensive intracranial subarachnoid haemorrhage. Cranial imaging failed to reveal any vascular anomaly or tumour. MRI of the neuroaxis revealed a melanoma metastasis at T10 with associated subarachnoid haemorrhage. We review the literature on this rare presentation of subarachnoid haemorrhage.
March 10, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28243752/erratum-to-convexity-subarachnoid-haemorrhage-has-a-high-risk-of-intracerebral-haemorrhage-in-suspected-cerebral-amyloid-angiopathy
#17
D Wilson, I C Hostettler, G Ambler, G Banerjee, H R Jäger, D J Werring
No abstract text is available yet for this article.
February 27, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28222628/safety-and-efficiency-of-flow-diverters-for-treating-small-intracranial-aneurysms-a-systematic-review-and-meta-analysis
#18
Xiyang Yao, Junwei Ma, Haiying Li, Haitao Shen, Xiaojun Lu, Gang Chen
Background We evaluated the safety and efficiency of flow diverters (FDs) in treating small intracranial aneurysms (IAs). Materials and Methods We reviewed the literature published in PubMed and EMBASE. R for Project software was used to calculate the complete aneurysm occlusion rates, procedure-related neurologic mortality, procedure-related neurologic morbidity and procedure-related permanent morbidity. Results Ten observational studies were included in this analysis. The complete aneurysm occlusion rate was 84...
February 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28213906/impact-of-dexamethasone-in-patients-with-aneurysmal-subarachnoid-haemorrhage
#19
P Czorlich, T Sauvigny, F Ricklefs, T Abboud, A Nierhaus, E Vettorazzi, D A Reuter, J Regelsberger, M Westphal, N O Schmidt
BACKGROUND AND PURPOSE: The role of corticosteroids in the treatment of patients with aneurysmal subarachnoid haemorrhage (SAH) has remained controversial for decades. Recent studies have suggested that the administration of corticosteroids in SAH patients is associated with favourable outcomes. Given their significant adverse effects, it is essential to identify those patients who will benefit from treatment with corticosteroids. METHODS: A retrospective analysis of a prospectively collected cohort (n = 306) with SAH who were treated by microsurgical clipping or endovascular intervention was performed...
April 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28203386/concurrent-subarachnoid-haemorrhage-and-st-elevation-myocardial-infarction
#20
Joon H Tan, Akhlaque Uddin, Juan P Fernandez
Rare case of concurrent subarachnoid haemorrhage and ST elevation myocardial infarction, highlighting the importance of detailed history in an emergency.
February 2017: JRSM Open
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