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https://www.readbyqxmd.com/read/29475164/thiazolidinediones-as-antidiabetic-agents-a-critical-review
#1
REVIEW
M J Nanjan, Manal Mohammed, B R Prashantha Kumar, M J N Chandrasekar
Thiazolidinediones (TZDs) or Glitazones are an important class of insulin sensitizers used in the treatment of Type 2 diabetes mellitus (T2DM). TZDs were reported for their antidiabetic effect through antihyperglycemic, hypoglycemic and hypolipidemic agents. In time, these drugs were known to act by increasing the transactivation activity of Peroxisome Proliferators Activated Receptors (PPARs). The clinically used TZDs that suffered from several serious side effects and hence withdrawn/updated later, were full agonists of PPAR-γ and potent insulin sensitizers...
February 12, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29474830/erythema-nodosum-leprosum-update-and-challenges-on-the-treatment-of-a-neglected-condition
#2
REVIEW
Perpétua do Socorro Silva Costa, Lucas Rosa Fraga, Thayne Woycinck Kowalski, Egon Luiz Rodrigues Daxbacher, Lavínia Schuler-Faccini, Fernanda Sales Luiz Vianna
Erythema Nodosum Leprosum (ENL) occurs due to the immunological complication of multibacillary leprosy and is characterized by painful nodules and systemic compromising. It is usually recurrent and/or chronic and has both physical and economic impact on the patient, being a very important cause of disability. In addition, ENL is a major health problem in countries where leprosy is endemic. Therefore, adequate control of this condition is important. The management of ENL aims to control acute inflammation and neuritis and prevent the onset of new episodes...
February 20, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29474789/tissue-and-organ-3d-bioprinting
#3
Min Zeng, Sha Jin, Kaiming Ye
Three-dimensional (3D) bioprinting enables the creation of tissue constructs with heterogeneous compositions and complex architectures. It was initially used for preparing scaffolds for bone tissue engineering. It has recently been adopted to create living tissues, such as cartilage, skin, and heart valve. To facilitate vascularization, hollow channels have been created in the hydrogels by 3D bioprinting. This review discusses the state of the art of the technology, along with a broad range of biomaterials used for 3D bioprinting...
February 1, 2018: SLAS Technology
https://www.readbyqxmd.com/read/29474605/cardiology-update-london-2017-ii
#4
Ruth Amstein
No abstract text is available yet for this article.
February 21, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29474604/cardiology-update-london-2017-i
#5
Andros Tofield
No abstract text is available yet for this article.
February 21, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29474519/victree-an-automated-framework-for-taxonomic-classification-from-protein-sequences
#6
Sejal Modha, Anil Thanki, Susan F Cotmore, Andrew J Davison, Joseph Hughes
Motivation: The increasing rate of submission of genetic sequences into public databases is providing a growing resource for classifying the organisms that these sequences represent. To aid viral classification, we have developed ViCTree, which automatically integrates the relevant sets of sequences in NCBI GenBank and transforms them into an interactive maximum likelihood phylogenetic tree that can be updated automatically. ViCTree incorporates ViCTreeView, which is a JavaScript-based visualisation tool that enables the tree to be explored interactively in the context of pairwise distance data...
February 20, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29474513/energide-cell-body-as-smallest-unit-of-eukaryotic-life
#7
František Baluška, Sherrie Lyons
Background: The evolutionary origin of the eukaryotic nucleus is obscure and controversial. Currently preferred are autogenic concepts; ideas of a symbiotic origin are mostly discarded and forgotten. Here we briefly discuss these issues and propose a new version of the symbiotic and archaeal origin of the eukaryotic nucleus. Scope and Conclusions: The nucleus of eukaryotic cells forms via its perinuclear microtubules, the primary eukaryotic unit known also as the Energide-cell body...
February 21, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29474481/a-dual-boundary-classifier-for-predicting-acute-hypotensive-episodes-in-critical-care
#8
Sakyajit Bhattacharya, Vijay Huddar, Vaibhav Rajan, Chandan K Reddy
An Acute Hypotensive Episode (AHE) is the sudden onset of a sustained period of low blood pressure and is one among the most critical conditions in Intensive Care Units (ICU). Without timely medical care, it can lead to an irreversible organ damage and death. By identifying patients at risk for AHE early, adequate medical intervention can save lives and improve patient outcomes. In this paper, we design a novel dual-boundary classification based approach for identifying patients at risk for AHE. Our algorithm uses only simple summary statistics of past Blood Pressure measurements and can be used in an online environment facilitating real-time updates and prediction...
2018: PloS One
https://www.readbyqxmd.com/read/29474330/with-severity-scores-updated-on-the-hour-data-science-inches-closer-to-the-bedside
#9
David M Maslove
No abstract text is available yet for this article.
March 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29474272/an-update-in-the-initial-management-of-paediatric-status-epilepticus
#10
Ben Lawton, Tessa Davis, Henry Goldstein, Andrew Tagg
PURPOSE OF REVIEW: Over the last 2 years, algorithms for the optimal management of status epilepticus have changed, as the medical community has recognized the need to terminate seizures in status in a timely manner. Recent research has evaluated the different choices of benzodiazepine and has given consideration to second-line treatment options. RECENT FINDINGS: There has been a move to examine alternatives to phenytoin (such as levetiracetam and lacosamide) as second-line agents...
February 22, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29474255/erratum-author-dr-c-h-chen-s-affiliations-updated
#11
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29474209/pulmonary-phenotypes-associated-with-genetic-variation-in-telomere-related-genes
#12
Thijs W Hoffman, Coline H M van Moorsel, Raphael Borie, Bruno Crestani
PURPOSE OF REVIEW: Genomic mutations in telomere-related genes have been recognized as a cause of familial forms of idiopathic pulmonary fibrosis (IPF). However, it has become increasingly clear that telomere syndromes and telomere shortening are associated with various types of pulmonary disease. Additionally, it was found that also single nucleotide polymorphisms (SNPs) in telomere-related genes are risk factors for the development of pulmonary disease. This review focuses on recent updates on pulmonary phenotypes associated with genetic variation in telomere-related genes...
February 21, 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29474064/a-space-efficient-direct-access-data-compression-approach-for-mass-spectrometry-imaging
#13
Patrik Källback, Anna Nilsson, Mohammadreza Shariatgorji, Per E Andren
Advances in mass spectrometry imaging that improve both spatial and mass resolution are resulting in increasingly larger data files that are difficult to handle with current software. We have developed a novel near-lossless compression method with data entropy reduction that reduces the file size significantly. The reduction in data size can be set at four different levels (coarse, medium, fine, and superfine) prior to running the data compression. This can be applied to spectra, spectrum-by-spectrum, or on the transpose arrays, array-by-array, to efficiently read the data without decompressing the whole dataset...
February 23, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29473945/home-based-primary-care-beyond-extension-of-the-independence-at-home-demonstration
#14
James Rotenberg, Bruce Kinosian, Peter Boling, George Taler
The Independence at Home (IAH) Demonstration Year 2 results confirmed that the first-year savings were 10 times as great as those of the pioneer accountable care organizations during their initial 2 years. We update projected savings from nationwide conversion of the IAH demonstration, incorporating Year 2 results and improving attribution of IAH-qualified (IAH-Q) Medicare beneficiaries to home-based primary care (HBPC) practices. Applying IAH qualifying criteria to beneficiaries in the Medicare 5% claims file, the effect of expanding HBPC to the 2...
February 23, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29473840/adaptive-correlation-model-for-visual-tracking-using-keypoints-matching-and-deep-convolutional-feature
#15
Yuankun Li, Tingfa Xu, Honggao Deng, Guokai Shi, Jie Guo
Although correlation filter (CF)-based visual tracking algorithms have achieved appealing results, there are still some problems to be solved. When the target object goes through long-term occlusions or scale variation, the correlation model used in existing CF-based algorithms will inevitably learn some non-target information or partial-target information. In order to avoid model contamination and enhance the adaptability of model updating, we introduce the keypoints matching strategy and adjust the model learning rate dynamically according to the matching score...
February 23, 2018: Sensors
https://www.readbyqxmd.com/read/29473763/statin-induced-myalgia-and-myositis-an-update-on-pathogenesis-and-clinical-recommendations
#16
Albert Selva-O'Callaghan, Marcelo Alvarado-Cardenas, Iago Pinal-Fernández, Ernesto Trallero-Araguás, José Cesar Milisenda, María Ángeles Martínez, Ana Marín, Moisés Labrador-Horrillo, Cándido Juárez, Josep María Grau-Junyent
Musculoskeletal manifestations are well-recognized side effects of treatment with statins. New advances in this field have appeared in recent years. This review focuses on the diagnosis of these conditions and their underlying pathogenesis, in particular immune-mediated necrotizing myopathy. Areas covered: Clinical phenotypes including rhabdomyolysis, myalgia and/or mild hyperCKemia, self-limited toxin statin myopathy, and immune-mediated necrotizing myopathy are herein described. Therapeutic recommendations and a diagnostic algorithm in statin-associated myopathy are also proposed...
February 23, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29473530/allergoids-for-allergy-treatment
#17
Jeronimo Carnes, Maria T Gallego, Raquel Moya, Victor Iraola
Background Chemically modified allergen extracts, known as allergoids, are commonly used for treating allergic patients. In general terms, the concept of allergoids implies allergen extracts with a reduction of their allergenicity maintaining their immunogenicity. Different methods to obtain allergoids have been developed in the past years, opening attractive lines of research. Objective To review the different approaches to allergoid development as well as their characterization, mechanism of action and efficacy and safety issues...
February 21, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29473515/updates-on-genome-wide-association-findings-in-eating-disorders-and-future-application-to-precision-medicine
#18
Lauren Breithaupt, Christopher Hubel, Cynthia M Bulik
Heterogeneity, frequent diagnostic fluctuation across presentations, and global concerns with the absence of effective treatments all encourage science that moves the field toward individualized or precision medicine in eating disorders. We review recent advances in psychiatric genetics focusing on genome-wide association studies (GWAS) in eating disorders and enumerate the prospects and challenges of a genomics-driven approach towards personalized intervention.
February 22, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29473513/the-role-of-lrrk2-in-neurodegeneration-of-parkinson-disease
#19
Qin Rui, Haibo Ni, Di Li, Rong Gao, Gang Chen
The leucine-rich repeat kinase 2 (LRRK2) gene and α-synuclein gene (SNCA) are the key influence factors of Parkinson's disease (PD). It is reported that dysfunction of LRRK2 may influence the accumulation of α-synuclein and its pathology to alter cellular functions and signaling pathways by the kinase activation of LRRK2. The accumulation of α-synuclein is one of the main stimulants of microglias acitiviton. Microglias are macrophages resided in the brain, and activation of microglials is believed to contribute to neuroinflammation and neuronal death in PD...
February 22, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29472969/student-expenses-in-residency-interviewing
#20
Anne Walling, Kari Nilsen, Paul Callaway, Jill Grothusen, Cole Gillenwater, Samantha King, Gregory Unruh
Background: The student costs of residency interviewing are of increasing concern but limited current information is available. Updated, more detailed information would assist students and residency programs in decisions about residency selection. The study objective was to measure the expenses and time spent in residency interviewing by the 2016 graduating class of the University of Kansas School of Medicine and assess the impact of gender, regional campus location, and primary care application...
August 2017: Kansas Journal of Medicine
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