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https://www.readbyqxmd.com/read/29909591/update-on-the-use-of-c1-esterase-inhibitor-replacement-therapy-in-the-acute-and-prophylactic-treatment-of-hereditary-angioedema
#1
REVIEW
H Henry Li, Marc Riedl, Jay Kashkin
In the vast majority of patients with hereditary angioedema (HAE), angioedema attacks are due to the quantitative or functional deficiency of C1-esterase inhibitor (C1-INH), which leads to increased vascular permeability and unregulated release of bradykinin. Exogenous administration of C1-INH is a rational way to restore the concentration and functional activity of this protein, regulate the release of bradykinin, and attenuate or prevent subcutaneous and submucosal edema associated with HAE. Recent international guidelines for the management of HAE include C1-INH as an option for acute treatment of HAE...
June 16, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29909568/association-between-chek2-1100delc-and-breast-cancer-a-systematic-review-and-meta-analysis
#2
REVIEW
Mingming Liang, Yun Zhang, Chenyu Sun, Feras Kamel Rizeq, Min Min, Tingting Shi, Yehuan Sun
INTRODUCTION: The association between the checkpoint kinase 2*1100delC (CHEK2*1100delC) and breast cancer has been extensively explored. OBJECTIVE: In light of the recent publication of studies on these specific findings, particularly regarding male patients with breast cancer, we performed an updated meta-analysis to investigate a more reliable estimate. METHODS: This meta-analysis included 26 published studies selected in a search of electronic databases up to January 2018, including 118,735 breast cancer cases and 195,807 controls...
June 16, 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/29909561/molecular-genetic-analysis-for-periodic-fever-syndromes-a-supplemental-role-for-the-diagnosis-of-adult-onset-still-s-disease
#3
Hongbin Li, Irina Abramova, Sandra Chesoni, Qingping Yao
Adult-onset Still's disease (AOSD) represents a systemic autoinflammatory disease (SAID), and its diagnostic criteria are clinical without genetic testing. Given shared manifestations between AOSD and hereditary SAIDs, molecular analysis may help differentiate these diseases. A PubMed literature search was conducted using key words "adult-onset Still's disease," "autoinflammatory disease," and "genetic mutation" between 1970 and February 2018. Articles on genetic mutations in the genes MEFV, TNFRSF1A, mevalonate kinase, or NOD2 for hereditary SAIDs in AOSD/systemic onset juvenile idiopathic arthritis (SJIA) patients were reviewed and analyzed...
June 17, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29909445/centers-for-disease-control-and-prevention-2017-guidelines-for-prevention-of-surgical-site-infections-review-and-relevant-recommendations
#4
REVIEW
K Keely Boyle, Sridhar Rachala, Scott R Nodzo
PURPOSE OF REVIEW: The associated patient morbidity and resource-intensive nature of managing surgical site infections (SSI) has focused attention toward not only improving treatment protocols but also enhancing preventative measures. The purpose of this review was to summarize the relevant updated CDC guidelines for the prevention of SSI that were released in 2017. The CDC recommends the integration of the guidelines for improvement in quality metrics, reportable outcomes, and patient safety...
June 16, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29909444/gender-disparities-in-presentation-management-and-outcomes-of-acute-myocardial-infarction
#5
REVIEW
Matthew Liakos, Puja B Parikh
PURPOSE OF REVIEW: This review provides updates in gender disparities in the symptom profile, risk factors, quality and timeliness of guideline-based medical care, and clinical outcomes, including mortality, bleeding, and vascular complications, in patients with acute myocardial infarction (AMI). RECENT FINDINGS: While AMI continues to be a leading cause of mortality in both men and women, significant gender differences exist in presentation, management, and outcomes...
June 16, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29909356/an-automatic-adaptive-information-based-algorithm-for-the-extraction-of-the-semg-envelope
#6
Simone Ranaldi, Cristiano De Marchis, Silvia Conforto
Surface ElectroMyography (sEMG) is widely used as a non-invasive tool for the assessment of motor control strategies. However, the standardization of the methods used for the estimation of sEMG amplitude is a problem yet to be solved; in most cases, sEMG amplitude is estimated through the extraction of the envelope of the signal via different low-pass filtering procedures with fixed cut-off frequencies chosen by the experimenter. In this work, we have shown how it is not possible to find the optimal choice of the cut-off frequency without any a priori knowledge on the signal; considering this, we have proposed an updated version of an iterative adaptive algorithm already present in literature, aiming to completely automatize the sEMG amplitude estimation...
June 14, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29909163/update-on-multiple-endocrine-neoplasia-type-1-and-2
#7
Abdallah Al-Salameh, Camille Baudry, Régis Cohen
Multiple endocrine neoplasia type 1 is a rare genetic syndrome, characterized by the co-occurrence, in the same individual or in related individuals of the same family, of hyperparathyroidism, duodenopancraetic neuroendocrine tumors, pituitary adenomas, adrenocortical tumors, and neuroendocrine tumors (carcinoids) in the thymus, the bronchi, or the stomach. Multiple endocrine neoplastic type 2 is a rare genetic syndrome, characterized by the familial occurrence of medullary thyroid carcinoma either isolated or associated with pheochromocytoma, primary hyperparathyroidism, or typical features (Marfanoid habitus, mucosal neuromas)...
June 13, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29909147/leaderless-synchronization-of-coupled-neural-networks-with-the-event-triggered-mechanism
#8
Siqi Lv, Wangli He, Feng Qian, Jinde Cao
This paper is concerned with leaderless synchronization of coupled delayed neural networks. A distributed event-triggered control strategy under the periodic sampling scheme is introduced to reduce control updates. By introducing a weighted average state as a virtual leader, the leaderless synchronization problem can be transformed to the stability problem of the error system, which is defined as the distance between each node and the virtual leader. A leaderless synchronization criterion under the periodic event-triggered scheme in strongly connected networks is first derived based on Finsler's lemma...
May 30, 2018: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29909048/serotonin-in-the-gut-blessing-or-a-curse
#9
REVIEW
Suhrid Banskota, Jean-Eric Ghia, Waliul I Khan
Serotonin (5-hydroxytryptamine or 5-HT) once most extensively studied as a neurotransmitter of the central nervous system, is seen to be predominantly secreted in the gut. About 95% of 5-HT is estimated to be found in gut mainly within the enterochromaffin cells whereas about 5% is found in the brain. 5-HT is an important enteric signaling molecule and is well known for playing a key role in sensory-motor and secretory functions in the gut. In recent times studies uncovering various new functions of gut-derived 5-HT indicate that many more are yet to be discovered in coming days...
June 14, 2018: Biochimie
https://www.readbyqxmd.com/read/29908876/prostate-imaging-reporting-and-data-system-steering-committee-pi-rads-v2-status-update-and-future-directions
#10
Anwar R Padhani, Jeffrey Weinreb, Andrew B Rosenkrantsz, Geert Villeirs, Baris Turkbey, Jelle Barentsz
CONTEXT: The Prostate Imaging-Reporting and Data System (PI-RADS) v2 analysis system for multiparametric magnetic resonance imaging (mpMRI) detection of prostate cancer (PCa) is based on PI-RADS v1, accumulated scientific evidence, and expert consensus opinion. OBJECTIVE: To summarize the accuracy, strengths and weaknesses of PI-RADS v2, discuss pathway implications of its use and outline opportunities for improvements and future developments. EVIDENCE ACQUISITION: For this consensus expert opinion from the PI-RADS steering committee, clinical studies, systematic reviews, and professional guidelines for mpMRI PCa detection were evaluated...
June 13, 2018: European Urology
https://www.readbyqxmd.com/read/29908815/preweaned-heifer-management-on-us-dairy-operations-part-i-descriptive-characteristics-of-preweaned-heifer-raising-practices
#11
N J Urie, J E Lombard, C B Shivley, C A Kopral, A E Adams, T J Earleywine, J D Olson, F B Garry
The objective of this study was to describe preweaned dairy heifer calf management practices on dairy operations across the United States that were used to analyze factors associated with colostrum quality and passive transfer, Cryptosporidium and Giardia, morbidity and mortality, and average daily gain. This study included 104 dairy operations in 13 states that participated in the National Animal Health Monitoring System's Dairy 2014 calf component study. This 18-mo longitudinal study focused on dairy heifer calves from birth to weaning, and data were collected on 2,545 heifer calves...
June 13, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29908393/an-update-on-adolescent-sleep-new-evidence-informing-the-perfect-storm-model
#12
REVIEW
Stephanie J Crowley, Amy R Wolfson, Leila Tarokh, Mary A Carskadon
The maturation of sleep regulatory systems during adolescence in combination with psychosocial and societal pressures culminate in a "Perfect Storm" of short and ill-timed sleep and the associated consequences for many youngsters. This model, first described by Carskadon in 2011, guides our current thinking of adolescent sleep behavior. Since the original description, the field has moved forward with remarkable pace, and this review aims to summarize recent progress and describe how this new work informs our understanding of sleep regulation and sleep behavior during this developmental time frame...
June 13, 2018: Journal of Adolescence
https://www.readbyqxmd.com/read/29908382/open-versus-french-door-laminoplasty-for-the-treatment-of-cervical-multilevel-compressive-myelopathy-a-meta-analysis
#13
REVIEW
Wenqi Luo, Yueying Li, Jianhui Zhao, Rui Gu, Rui Jiang, Phd Feng Lin
PURPOSE: To compare the clinical outcomes and postoperative complications between open-door laminoplasty (ODL) versus French-door laminoplasty (FDL) for the treatment of cervical multilevel compressive myelopathy. METHODS: We comprehensively searched PubMed, EMBASE, Cochrane library, and China National Knowledge Infrastructure (CNKI) to identify relevant articles. The search results were last updated on January 1, 2018. All values of weighted mean difference (WMD) and odds ratio(OR) are expressed as ODL relative to FDL...
June 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29908248/detection-of-single-alpha-helices-in-large-protein-sequence-sets-using-hardware-acceleration
#14
Ákos Kovács, Dániel Dudola, László Nyitray, Gábor Tóth, Zoltán Nagy, Zoltán Gáspári
Single alpha-helices (SAHs) are increasingly recognized as important structural and functional elements of proteins. Comprehensive identification of SAH segments in large protein datasets was largely hindered by the slow speed of the most restrictive prediction tool for their identification, FT_CHARGE on common hardware. We have previously implemented an FPGA-based version of this tool allowing fast analysis of a large number of sequences. Using this implementation, we have set up of a semi-automated pipeline capable of analyzing full UniProt releases in reasonable time and compiling monthly updates of a comprehensive database of SAH segments...
June 13, 2018: Journal of Structural Biology
https://www.readbyqxmd.com/read/29907575/current-evidence-for-anesthesia-management-during-endovascular-stroke-therapy-updated-systematic-review-and-meta-analysis
#15
Nitin Goyal, Konark Malhotra, Muhammad F Ishfaq, Georgios Tsivgoulis, Christopher Nickele, Daniel Hoit, Adam S Arthur, Andrei V Alexandrov, Lucas Elijovich
INTRODUCTION: Debate continues about the optimal anesthetic management for patients undergoing endovascular treatment (ET) of acute ischemic stroke due to emergent large vessel occlusion. OBJECTIVE: To compare, using current evidence, the clinical outcomes and procedural characteristics among patients undergoing general anesthesia (GA) and local or monitored anesthesia (non-GA). METHODS: We performed a systematic review and meta-analysis of all available studies that involved the use of stent retrievers for ET (stentriever group)...
June 15, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29907554/a-surveillance-infrastructure-for-malaria-analytics-provisioning-data-access-and-preservation-of-interoperability
#16
Mohammad Sadnan Al Manir, Jon Haël Brenas, Christopher Jo Baker, Arash Shaban-Nejad
BACKGROUND: According to the World Health Organization, malaria surveillance is weakest in countries and regions with the highest malaria burden. A core obstacle is that the data required to perform malaria surveillance are fragmented in multiple data silos distributed across geographic regions. Furthermore, consistent integrated malaria data sources are few, and a low degree of interoperability exists between them. As a result, it is difficult to identify disease trends and to plan for effective interventions...
June 15, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29907542/society-of-hematologic-oncology-soho-state-of-the-art-updates-and-next-questions-myelodysplastic-syndromes
#17
REVIEW
Valeria Santini
In the past few months, 2 main streams of research have dominated the panorama of myelodysplastic syndrome (MDS) investigations: deepening the insight into the pathogenic role, hierarchy, and prognostic effect of somatic mutations and, as a consequence, into the effect of inherited congenital predisposing conditions and the second, quite interlinked with the first, analyzing inflammation and innate immunity in patients with MDS. The research devoted to clarifying the mechanisms of action and mechanisms of resistance to hypomethylating agents has also advanced, mostly resulting from different approaches to the study of DNA methylation...
May 23, 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29907519/testing-for-turkeys-faith-based-community-hiv-testing-initiative-an-update
#18
Mary DeGrezia, Dorcas Baker, Ingrid McDowell
Testing for Turkeys (TFT) HIV/hepatitis C virus (HCV) and sexually transmitted infection (STI) testing initiative is a joint effort between Older Women Embracing Life (OWEL), Inc., a nonprofit faith-based community HIV support and advocacy organization; the Johns Hopkins University Regional Partner MidAtlantic AIDS Education and Training Center (MAAETC); and the University of Maryland, Baltimore JACQUES Initiative (JI), and is now in its 11th year of providing HIV outreach, testing, and linkage to care. Since 2008, the annual TFT daylong community HIV testing and linkage to care initiative has been held 2 weeks before Thanksgiving at a faith-based center in Baltimore, Maryland, in a zip code where one in 26 adults and adolescents ages 13 years and older are living with HIV (Maryland Department of Health, Center for HIV Surveillance, Epidemiology, and Evaluation, 2017)...
June 4, 2018: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/29907461/vascular-anomalies
#19
REVIEW
Amir H Taghinia, Joseph Upton
Vascular anomalies encompass a wide variety of clinical conditions involving the vasculature. Over the past several decades, the terminology has changed as our understanding of these conditions has improved. A well-accepted classification scheme has evolved with constant additions, updates, and revisions. Imaging techniques have also advanced with greater resolution and a better understanding of the correlation between imaging, clinical behavior, and natural history. Meanwhile, the treatment of these conditions has also changed, with greater focus on minimally invasive techniques as opposed to radical surgery...
June 12, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29907380/monoclonal-gammopathies-of-unknown-significance-and-smoldering-myeloma-assessment-and-management-of-the-elderly-patients
#20
Verónica González-Calle, María Victoria Mateos
Monoclonal gammopathy of unknown significance (MGUS) is the most frequent plasma cell disorder that commonly affects elderly patients. Although it is an asymptomatic condition, as well as smoldering myeloma (SMM), the risk of progression to multiple myeloma requiring therapy or other B-cell disorders varies greatly for individual patients, remaining low for MGUS (1% per year), while higher and not uniform for SMM patients (10% per year). This scenario implies some special considerations regarding assessment and follow-up, especially in the elderly...
June 12, 2018: European Journal of Internal Medicine
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