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https://www.readbyqxmd.com/read/28927990/down-for-the-count-the-critical-endpoint-in-ototoxicity-remains-the-cytocochleogram
#1
REVIEW
David V Gauvin, Joshua Yoder, Andrea Koch, Zachary J Zimmermann, Rachel L Tapp
There are three major assays that must be conducted in standard investigational new drug (IND) -enabling ototoxicity study designs: 1) functional acoustic threshold measurements (Auditory Brainstem Respsonse, ABR); 2) otohistopathology and 3) cytocochleograms. We provide evidence to demonstrate the unreliability of auditory threshold shifts (ABRs) to predict cochlear cell death and build a case for conducting full cochlea processing and cell count measurements from the complete cochlea from apex to base.
September 16, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28899789/the-evolutionary-logic-of-sepsis
#2
Lajos Rózsa, Péter Apari, Mihály Sulyok, Dennis Tappe, Imre Bodó, Richárd Hardi, Viktor Müller
The recently proposed Microbiome Mutiny Hypothesis posits that members of the human microbiome obtain information about the host individuals' health status and, when host survival is compromised, switch to an intensive exploitation strategy to maximize residual transmission. In animals and humans, sepsis is an acute systemic reaction to microbes invading the normally sterile body compartments. When induced by formerly mutualistic or neutral microbes, possibly in response to declining host health, sepsis appears to fit the 'microbiome mutiny' scenario except for its apparent failure to enhance transmission of the causative organisms...
September 9, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28892418/shared-decision-making-and-time-to-exacerbation-in-children-with-asthma
#3
Tsai-Ling Liu, Yhenneko J Taylor, Rohan Mahabaleshwarkar, Christopher M Blanchette, Hazel Tapp, Michael F Dulin
BACKGROUND: Although shared decision making (SDM) is a promising approach for improving outcomes for patients with chronic diseases, no evidence currently supports the use of SDM to delay asthma exacerbations. We evaluated the impact of an SDM intervention implemented by providers in a real-world setting on time to exacerbation in children with asthma. METHODS: This study used a prospective cohort observed between 2011-2013 at five primary care practices that serve vulnerable populations (e...
September 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28888707/the-value-of-laparoscopy-in-the-management-of-chronic-groin-pain
#4
Abdulzahra Hussain, Ihsan Al-Shoek, Ajay Arora, Jonathan Walczak, Shamsi El-Hasani
BACKGROUND: Chronic groin pain problem represents a diagnostic and management challenge. This study is reporting all patients who underwent laparoscopic exploration of the groin and pelvis for undiagnosed chronic groin pain. MATERIALS AND METHODS: A retrospective cohort study. Evaluators were not involved in the operations. Laparoscopic exploration and mesh insertion using Trans-Abdominal Pre-Preitoneal (TAPP) approach was performed for all patients. Follow up in the; clinic at 2 weeks and 6 months was arranged...
September 6, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28876607/laparoscopic-approach-to-combined-bilateral-inguinal-and-ventral-hernias
#5
H Bougard
Herniosis is a well-documented phenomenon amongst patients who develop any hernia over their lifetime. Multiple hernias at different anatomical locations are quite common though they more often occur metachronously. When they present synchronously, there is an additional advantage to tackling these hernias laparoscopically as it affords the advantage of thorough inspection of the entire peritoneal cavity and the ability to address all hernias simultaneously. This video demonstrates one of the modified approached to the groin and midline that facilities a combined procedure without the need for additional port placements...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28834353/a-new-energy-saving-catalytic-system-co2-activation-via-metal-carbon-catalyst
#6
Danim Yun, Dae Sung Park, Kyung Rok Lee, Yang Sik Yun, Tae Yong Kim, Hongseok Park, Hyunjoo Lee, Jongheop Yi
Conversion of carbon dioxide for producing useful chemicals is an attractive method to reduce greenhouse gas emissions and to produce sustainable chemicals. However, the thermodynamic stability of CO₂ necessitates high levels of energy consumption for its conversion to chemicals. Here, we suggest a new catalytic system with an alternative heating system allowing for minimal energy consumption during CO₂ conversion. In this system, electrical energy is transferred as heat energy to the metal supported on carbon catalyst...
August 21, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28831728/robotic-radical-prostatectomy-with-concomitant-repair-of-inguinal-hernia-is-it-safe
#7
Travis Rogers, Eduardo Parra-Davila, Flavio Malcher, Carlos Hartmann, Bernardo Mastella, Guiherme de Araújo, Gabriel Ogaya-Pinies, Carlos Ortiz-Ortiz, Eduardo Hernandez-Cardona, Vipul Patel, Leandro Totti Cavazzola
Robotic radical prostatectomy (RARP) is well established as a safe and effective treatment for prostate cancer. According to published studies, patients undergoing RARP are at increased risk of being diagnosed with an inguinal hernia after RARP and are four times more likely to have an inguinal hernia repair (IHR) following RARP. Several studies have demonstrated the effectiveness and safety of IHR during RARP. Overall, it has been observed that IHR adds on average, 12-15 min in total surgical time and there were no significant differences between RARP with or without IHR with respect to postoperative complications...
August 22, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28800266/impact-of-shared-decision-making-on-asthma-quality-of-life-and-asthma-control-among-children
#8
Yhenneko J Taylor, Hazel Tapp, Lindsay E Shade, Tsai-Ling Liu, Jessica Lauren Mowrer, Michael F Dulin
OBJECTIVE: Few studies have examined the effectiveness of shared decision making (SDM) in clinical practice. This study evaluated the impact of SDM on quality of life and symptom control in children with asthma. METHODS: We conducted a prospective 3-year study in six community-based practices serving a low-income patient population. Practices received training on SDM using an evidence-based toolkit. Patients aged 2 to 17 with a diagnosis of asthma were identified from scheduling and billing data...
August 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28799065/laparoscopic-inguinal-hernioplasty-after-robot-assisted-laparoscopic-radical-prostatectomy
#9
M Sakon, Y Sekino, M Okada, H Seki, Y Munakata
PURPOSE: To evaluate the efficacy and safety of laparoscopic transabdominal preperitoneal (TAPP) inguinal hernia repair in patients who have undergone robot-assisted laparoscopic radical prostatectomy (RALP). METHODS: From July 2014 to December 2016, TAPP inguinal hernia repair was conducted in 40 consecutive patients who had previously undergone RALP. Their data were retrospectively analyzed as an uncontrolled case series. RESULTS: The mean operation time in patients who had previously undergone RALP was 99...
August 10, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28771693/herpes-simplex-virus-1-interferes-with-autophagy-of-murine-dendritic-cells-and-impairs-their-ability-to-stimulate-cd8-t-lymphocytes
#10
Ramachandramouli Budida, Metodi V Stankov, Katinka Döhner, Anna Buch, Diana Panayotova-Dimitrova, Kim A Tappe, Anja Pohlmann, Beate Sodeik, Georg M N Behrens
The MHC class I presentation is responsible for the presentation of viral proteins to CD8(+) T lymphocytes and mainly depends on the classical antigen processing pathway. Recently, a second pathway involving autophagy has been implicated in this process. Here, we show an increase in the capacity of murine dendritic cells (DCs) to present viral antigens on MHC class I after infection with a mutant herpes simplex virus 1 (HSV-1-Δ34.5), lacking infected cell protein 34.5 (ICP34.5), when compared to its parental HSV-1 strain...
August 3, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28751063/a-prospective-randomized-study-comparing-laparoscopic-transabdominal-preperitoneal-tapp-versus-lichtenstein-repair-for-bilateral-inguinal-hernias
#11
Benedetto Ielpo, Hipolito Duran, Eduardo Diaz, Isabel Fabra, Riccardo Caruso, Luis Malavé, Valentina Ferri, Sara Lazzaro, Denis Kalivaci, Yolanda Quijano, Emilio Vicente
BACKGROUND: In literature, only a few studies have prospectively compared the results of laparoscopic with open inguinal hernia repair yet none have compared bilateral inguinal hernia repair. The aim of this study is to compare the open Lichtenstein repair (OLR) with laparoscopic trans-abdominal preperitoneal (TAPP) repair in patients undergoing surgery for bilateral inguinal hernia. METHODS: Patients were prospectively randomized between March 2013 and March 2015...
July 19, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28707149/long-term-quality-of-life-and-outcomes-following-robotic-assisted-tapp-inguinal-hernia-repair
#12
Andrew Iraniha, Joshua Peloquin
Laparoscopic TAPP inguinal hernia repair is an established alternative to open hernia repair, which offers equivalent outcomes with less postoperative pain and faster recovery. Unfortunately, it remains technically challenging, requiring advanced laparoscopic skills which have limited its popularity among surgeons. The robotic platform has the potential to overcome these challenges. The objective of this study was to examine the long-term quality of life and outcomes following robotic assisted TAPP inguinal hernia repair, since these data have not been reported up to now...
July 13, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28697253/effect-of-antidepressant-switching-vs-augmentation-on-remission-among-patients-with-major-depressive-disorder-unresponsive-to-antidepressant-treatment-the-vast-d-randomized-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
Somaia Mohamed, Gary R Johnson, Peijun Chen, Paul B Hicks, Lori L Davis, Jean Yoon, Theresa C Gleason, Julia E Vertrees, Kimberly Weingart, Ilanit Tal, Alexandra Scrymgeour, David D Lawrence, Beata Planeta, Michael E Thase, Grant D Huang, Sidney Zisook, Sanjai D Rao, Patricia D Pilkinton, James A Wilcox, Ali Iranmanesh, Mamta Sapra, George Jurjus, James P Michalets, Muhammed Aslam, Thomas Beresford, Keith D Anderson, Ronald Fernando, Sriram Ramaswamy, John Kasckow, Joseph Westermeyer, Gihyun Yoon, D Cyril D'Souza, Gunnar Larson, William G Anderson, Mary Klatt, Ayman Fareed, Shabnam I Thompson, Carlos J Carrera, Solomon S Williams, Timothy M Juergens, Lawrence J Albers, Clifford S Nasdahl, Gerardo Villarreal, Julia L Winston, Cristobal A Nogues, K Ryan Connolly, Andre Tapp, Kari A Jones, Gauri Khatkhate, Sheetal Marri, Trisha Suppes, Joseph LaMotte, Robin Hurley, Aimee R Mayeda, Alexander B Niculescu, Bernard A Fischer, David J Loreck, Nicholas Rosenlicht, Steven Lieske, Mitchell S Finkel, John T Little
Importance: Less than one-third of patients with major depressive disorder (MDD) achieve remission with their first antidepressant. Objective: To determine the relative effectiveness and safety of 3 common alternate treatments for MDD. Design, Setting, and Participants: From December 2012 to May 2015, 1522 patients at 35 US Veterans Health Administration medical centers who were diagnosed with nonpsychotic MDD, unresponsive to at least 1 antidepressant course meeting minimal standards for treatment dose and duration, participated in the study...
July 11, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28670761/models-of-childhood-cancer-survivorship-care-in-australia-and-new-zealand-strengths-and-challenges
#14
Christina Signorelli, Claire E Wakefield, Jordana K McLoone, Joanna E Fardell, Renae A Lawrence, Michael Osborn, Jo Truscott, Heather Tapp, Richard J Cohn
AIM: Childhood cancer survivors remain at risk of developing life-altering and/or life-threatening health conditions following the completion of curative treatment. However, no uniform model of care for childhood cancer survivors exists in Australia and New Zealand (ANZ). This study reports on current childhood cancer survivorship care in ANZ, highlighting the challenges childhood cancer survivor long-term follow-up (LTFU) clinics face. METHODS: We conducted semistructured, telephone interviews with the pediatric medical director and clinical nurse consultant from all 11 LTFU clinics at tertiary referral pediatric oncology units across ANZ (n = 19; 100% response rate)...
July 3, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28632242/exploring-gender-differences-in-self-reported-physical-activity-and-health-among-older-caregivers
#15
Colleen A Cuthbert, Kathryn King-Shier, Dianne Tapp, Dean Ruether, S Nicole Culos-Reed
PURPOSE/OBJECTIVES: To document self-reported physical health and activity levels of older caregivers. Gender differences in physical health, physical activity levels, and predictors of physical activity were also examined.
. DESIGN: A cross-sectional study.
. SETTING: Tom Baker Cancer Centre in Calgary, Alberta, Canada.
. SAMPLE: 130 caregivers aged 60 years or older caring for individuals with breast, prostate, or colorectal cancer...
July 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28593409/validation-of-newly-developed-physical-laparoscopy-simulator-in-transabdominal-preperitoneal-tapp-inguinal-hernia-repair
#16
Yuichi Nishihara, Yoh Isobe, Yuko Kitagawa
BACKGROUND: A realistic simulator for transabdominal preperitoneal (TAPP) inguinal hernia repair would enhance surgeons' training experience before they enter the operating theater. The purpose of this study was to create a novel physical simulator for TAPP inguinal hernia repair and obtain surgeons' opinions regarding its efficacy. METHODS: Our novel TAPP inguinal hernia repair simulator consists of a physical laparoscopy simulator and a handmade organ replica model...
June 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28585834/acute-consumption-of-flavan-3-ol-enriched-dark-chocolate-affects-human-endogenous-metabolism
#17
Luisa Martha Ostertag, Mark Philo, Ian J Colquhoun, Henri S Tapp, Shikha Saha, Garry G Duthie, E Kate Kemsley, Baukje de Roos, Paul A Kroon, Gwénaëlle Le Gall
Flavan-3-ols and methylxanthines have potential beneficial effects on human health including reducing cardiovascular risk. We performed a randomized controlled cross-over intervention trial to assess the acute effects of consumption of flavan-3-ol-enriched dark chocolate, compared with standard dark chocolate and white chocolate, on the human metabolome. We assessed the metabolome in urine and blood plasma samples collected before and at 2 h and 6 h after consumption of chocolates in 42 healthy volunteers using a non-targeted metabolomics approach...
June 6, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28551250/the-contribution-of-alliaceous-and-cruciferous-vegetables-to-dietary-sulphur-intake
#18
Joanne F Doleman, Katrijn Grisar, Lena Van Liedekerke, Shikha Saha, Mark Roe, Henri S Tapp, Richard F Mithen
Despite its importance in many areas of human metabolism, there are no recommended daily intake guide lines for sulphur. It is generally assumed that most dietary sulphur originates from intake of methionine and cysteine. We estimated sulphur intake from food diaries, and validated the results with the use of a duplicate diet analyses. Sulphur intake estimations were highly correlated with that obtain through an elemental analysis of duplicate diets, with a mean±sd daily intakes of 956±327.9mg estimated from diet diary analyses and 935±329...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28510593/no-serological-evidence-for-zika-virus-infection-and-low-specificity-for-anti-zika-virus-elisa-in-malaria-positive-individuals-among-pregnant-women-from-madagascar-in-2010
#19
Norbert Georg Schwarz, Eva Mertens, Doris Winter, Oumou Maiga-Ascofaré, Denise Dekker, Stephanie Jansen, Dennis Tappe, Njary Randriamampionona, Jürgen May, Raphael Rakotozandrindrainy, Jonas Schmidt-Chanasit
It was previously reported that a malaria infection may interfere with the specificity of a commercial ELISA test against Zika virus (ZIKV). We analyzed 1,216 plasma samples from healthy, pregnant women collected in two sites in Madagascar in 2010 for ZIKV antibodies using a commercial ELISA and for Plasmodium infection by PCR. This screen revealed six putative ZIKV-positive samples by ELISA. These results could not be confirmed by indirect immunofluorescence assays or virus neutralization tests. Four of these six samples were also positive for P...
2017: PloS One
https://www.readbyqxmd.com/read/28507989/diagnostic-laparoscopy-as-decision-tool-for-re-recurrent-inguinal-hernia-treatment-following-open-anterior-and-laparo-endoscopic-posterior-repair
#20
Ferdinand Köckerling, Christine Schug-Pass
INTRODUCTION: The guidelines of the international hernia societies recommend posterior repair in laparo-endoscopic technique for recurrent inguinal hernia after open anterior mesh repair and, conversely, open anterior repair for recurrence after laparo-endoscopic primary repair. Even when these guidelines are followed, already 1 year after repair a re-recurrence rate of 1-2% must be expected, with that rate rising further in the subsequent years. Accordingly, increasingly more patients with re-recurrence after anterior and posterior mesh implantation must be treated, which constitutes a problem that to date has been investigated in only very few studies...
2017: Frontiers in Surgery
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