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Giant cell tumor

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https://www.readbyqxmd.com/read/29333854/cucurbit-8-uril-based-giant-supramolecular-vesicles-highly-stable-versatile-carriers-for-photoresponsive-and-targeted-drug-delivery
#1
Cuihua Hu, Ningning Ma, Fei Li, Yu Fang, Yao Liu, Linlu Zhao, Shanpeng Qiao, Xiumei Li, Xiaojia Jiang, Tiezhu Li, Fangzhong Shen, Yibing Huang, Quan Luo, Junqiu Liu
Highly stable giant supramolecular vesicles were constructed by hierarchical self-assembly of cucurbit[8]uril (CB[8])-based supra-amphiphiles for photoresponsive and targeted intracellular drug delivery. These smart vesicles can encapsulate the model drugs with high loading efficiencies, and then release them by manipulating photoswitchable CB[8] heteroternary complexation to regulate the formation and dissociation of supra-amphiphiles that cause dramatic morphological changes of the assemblies to achieve remote optically-controlled drug delivery...
January 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29332062/cytologic-features-of-malignant-melanoma-with-osteoclast-like-giant-cells
#2
José A Jiménez-Heffernan, Magdalena Adrados, Patricia Muñoz-Hernández, Paloma Fernández-Rico, Ana I Ballesteros-García, Javier Fraga
BACKGROUND: Malignant melanoma showing numerous osteoclast-like giant cells (OGCs) is an uncommon morphologic phenomenon, rarely mentioned in the cytologic literature. The few reported cases seem to have an aggressive clinical behavior. Although most findings support monocyte/macrophage differentiation, the exact nature of OGCs is not clear. CASE: A 57-year-old woman presented with an inguinal lymphadenopathy. Sixteen years before, cutaneous malignant melanoma of the lower limb had been excised...
January 13, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29325960/results-of-biopsy-proven-sellar-germ-cell-tumors-nine-years-experience-in-a-single-center
#3
Yi Zhang, Huijuan Zhu, Kan Deng, Wenbin Ma, Yu Wang, Jian Sun, Xin Lian, Hui Pan, Renzhi Wang, Yong Yao
BACKGROUND: The biopsy is recognized as the most accurate method to determine the histological characterization of sellar germ cell tumors. It is very difficult to evaluate the prognosis before histological confirmation. OBJECTIVES: This study aimed to evaluate the independent prognostic risk factors of patients with sellar germ cell tumors (GCTs). METHODS: From January 2008 to December 2015, 61 patients who were histologically diagnosed as sellar GCTs did follow-ups and were included in this retrospective study...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29325251/-extrapleural-solitary-fibrous-tumor-with-uncommon-histology-a-clinicopathologic-analysis-of-7-cases
#4
M Zhao, Z R Yang, Y B Wang, Y Chen, G W Qi, Y J Yan, W J Xu, G Q Ru, X L He
Objective: To investigate the clinicopathologic characteristics, immunophenotypes, and differential diagnostic features of extra-pleural solitary fibrous tumor (SFT) with uncommon histology. Methods: Seven cases of extra-pleural SFT with uncommon histology were collected during January 2015 and December 2016 in Zhejiang Provincal People's Hospital; the clinical and radiologic features, histomorphology, immunophenotype and prognosis were analyzed. EnVision method was used for immunohistochemical staining of STAT6, CD34 and other differential diagnosis associated markers...
January 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29322494/common-primary-and-secondary-causes-of-headache-in-the-elderly
#5
Tara L Sharma
OBJECTIVE/BACKGROUND: Headache in the elderly, defined as individuals aged 65 and older, although less prevalent than younger individuals, can present as a diagnostic challenge, given the increase in potentially fatal diseases within this population. METHODS: These individuals require a complete history, neurological examination, and assessment of potential secondary causes of headaches. RESULTS: Secondary causes include temporal or giant cell arteritis, subdural hematomas, central nervous system (CNS) tumors, strokes, and CNS infections...
January 11, 2018: Headache
https://www.readbyqxmd.com/read/29316740/benzo-a-pyrene-alters-the-expression-of-genes-in-a549-lung-cancer-cells-and-cancer-stem-cells
#6
Yesol Bak, Hui-Joo Jang, Ji-Hye Seo, Su-Hyun No, Jung-Il Chae, Jintae Hong, Do-Young Yoon
Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a principal component of cigarette smoke. B[a]P can cause lung carcinogenesis and plays a key role in lung cancer progression. The role of B[a]P has been reported in lung cancer, but its effects on lung cancer stem cells have not been investigated. Emerging evidence indicates that cancer stem cells (CSCs) are associated with carcinogenesis, tumor initiation, relapse, and metastasis. Therefore, targeting CSCs to defeat cancer is a challenging issue in the clinic...
January 11, 2018: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29315595/mid-to-long-term-clinical-outcome-of-giant-cell-tumor-of-bone-treated-with-calcium-phosphate-cement-following-thorough-curettage-and-phenolization
#7
Akihiko Takeuchi, Prakrit Suwanpramote, Norio Yamamoto, Toshiharu Shirai, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Takashi Higuchi, Kensaku Abe, Hiroyuki Tsuchiya
BACKGROUND AND OBJECTIVES: Giant cell tumors of bone (GCTB) are intermediate and locally aggressive bone tumor. Calcium phosphate cement (CPC) is a bone void filler used in orthopaedic surgery. This study investigated the clinical outcome of GCTB treated with thorough curettage, phenolization, and CPC. METHODS: We investigated 26 patients with at least 36 months of follow-up. The mean age and follow-up were 37 years (range: 19-63) and 87 months (range: 38-169), respectively...
January 8, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29314220/histopathology-of-synovial-cysts-of-the-spine
#8
Ivan Chebib, Connie Y Chang, Joseph H Schwab, Darcy A Kerr, Vikram Deshpande, G Petur Nielsen
AIMS: Cystic lesions derived from the synovial and ligamentous structures of the spine have varied histologic appearances. Not uncommonly, there is discrepancy between the clinico-radiologic diagnosis and histology. Therefore, we sought to characterize the histologic features of tissue submitted as "synovial cysts" of the spine. METHODS: Resected specimens of the spine labeled "synovial cysts" and "lumbar cysts" were histologically evaluated and classified based on histopathologic features...
January 4, 2018: Histopathology
https://www.readbyqxmd.com/read/29312571/systematic-analysis-reveals-tumor-enhancing-and-suppressing-micrornas-in-drosophila-epithelial-tumors
#9
Zhiqiang Shu, Yi-Chun Huang, William H Palmer, Yoichiro Tamori, Gengqiang Xie, Hui Wang, Nan Liu, Wu-Min Deng
Despite their emergence as an important class of noncoding RNAs involved in cancer cell transformation, invasion, and migration, the precise role of microRNAs (miRNAs) in tumorigenesis remains elusive. To gain insights into how miRNAs contribute to primary tumor formation, we conducted an RNA sequencing (RNA-Seq) analysis of Drosophila wing disc epithelial tumors induced by knockdown of a neoplastic tumor-suppressor gene (nTSG) lethal giant larvae (lgl), combined with overexpression of an active form of oncogene Ras (RasV12 ), and identified 51 mature miRNAs that changed significantly in tumorous discs...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310408/case-report-repairing-orbital-skin-defects-using-composite-flaps-after-giant-eyelid-derived-tumor-excision-and-orbital-exenteration
#10
Bin Fan, Jian-Ju Liu, Bei-Fen Wang, Ying-Jian Sun, Guang-Yu Li
RATIONALE: Though giant malignant tumors arising in the eyelid are rare, they often require extensive surgery for removal along with orbital exenteration. Because of this, repairing orbital defects is an important factor in the surgical strategy. PATIENT CONCERNS: Case 1 was a 78-year-old nomad man who presented in the Department of Ophthalmology with a giant tumor in his right eyelid, which had developed over three years. Clinical examination revealed a huge pigmented, nonhealing ulcerated lesion, approximately 52×44×40 mm in size...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29303762/giant-schwannoma-of-the-hard-palate-a-literature-review-and-report-of-an-uncommon-case
#11
Cristinne Andrade Melo, Paulo Almeida-Júnior, Allan Ulisses de Carvalho Melo, Cyntia Ferreira Ribeiro, Cláudio Élcio Siqueira de Lira, Juliana Batista Melo da Fonte, Maria Fátima Batista de Melo, Wilton Mitsunari Takeshita, Ricardo Luiz Cavalcanti de Albuquerque-Júnior
Schwannomas (also known as neurilemomas) are benign tumors that arise from the Schwann cells of the nerve sheath. While they seldom occur in the oral cavity, the tongue is the most common site. Palatal schwannomas are extremely rare. This article reports a case of a large, slowly developing schwannoma that caused bone erosion in the hard palate of an 18-year-old man. The diagnosis was based on histopathologic and immunohistochemical findings. The tumor was completely excised, and no recurrence was observed at a 1-year follow-up...
January 2018: General Dentistry
https://www.readbyqxmd.com/read/29303366/current-clinical-radiological-and-treatment-perspectives-of-patellofemoral-pain-syndrome
#12
Aishwarya Gulati, Christopher McElrath, Vibhor Wadhwa, Jay P Shah, Avneesh Chhabra
Anterior knee pain in active young adults is commonly related to patellofemoral (PF) pain syndrome (PFPS), which can be broadly classified into patellar malalignment and patellar maltracking. PFPS can be caused by a host of miserable malalignments, such as excessive femoral antetorsion, tibial varus / external rotation, knee valgus and pes planus. Radiographic, CT and MRI evaluations are commonly obtained to further elucidate the malalignment and maltracking abnormalities and exclude other related differentials, such as lateral meniscus tear, extensor tendon tear, anterior tenosynovial giant cell tumor and plica syndrome...
January 5, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29299501/giant-cell-tumor-of-the-sacrum-series-of-19-patients-and-review-of-the-literature
#13
Khodamorad Jamshidi, Abolfazl Bagherifard, Alireza Mirzaei, Mehrdad Bahrabadi
There are still some debates regarding the best treatment of Giant Cell Tumor (GCT) of the sacrum. Since GCT of this location is rare, therapeutic strategies are mainly based on the treatment of GCT in other anatomic locations. The objective of this study was to evaluate the oncologic and clinical results of surgical management of sacral GCT with and without local adjuvant therapy. Medical records of 19 patients diagnosed with GCT of the sacrum, were retrospectively reviewed. Sixteen patients were treated by intralesional curettage and three patients with marginal resection...
November 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29296223/development-and-validation-of-a-prognostic-index-to-predict-pulmonary-metastasis-of-giant-cell-tumor-of-bone
#14
Bo Wang, Wei Chen, Xianbiao Xie, Jian Tu, Gang Huang, Changye Zou, Junqiang Yin, Lili Wen, Jingnan Shen
Purpose: Giant cell tumor of bone (GCTB) is an intermittent tumor with a low probability of pulmonary metastasis. Our aim was to investigate the risk factors and establish a nomogram predictive model for GCTB pulmonary metastasis. Methods: We retrospectively evaluated GCTB patients at our center from 1991 to 2014. The cohort was randomized into training and validation sets. Univariate and multivariate analyses were used to evaluate the risk factors of pulmonary metastasis...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29291377/giant-intracardiac-smooth-muscle-cell-tumor-presenting-as-superior-vena-cava-syndrome
#15
Alejandro E Murillo-Berlioz, Kyongjune Benjamin Lee, Gregory D Trachiotis, Klaus Kühn
We report the case of a 53-year-old male presenting with a superior vena cava syndrome secondary to a giant intracardiac mass occupying the majority of the right cavities of the heart. A mass of 10.5 cm x 9.5 cm x 4.0 cm originating from the superior vena cava and occupying most of the right atrium, extending through the tricuspid valve into the right ventricle. The mass was resected and the patient was discharged on postoperative day eleven. Pathology report revealed the mass to be a smooth-muscle cell tumor of unknown malignant potential (STUMP)...
December 29, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29283151/unusual-intraconal-localization-of-orbital-giant-cell-angiofibroma
#16
Meryem Altin Ekin, Seyda Karadeniz Ugurlu, Fulya Cakalagaoglu
Giant cell angiofibroma (GCA) is a recently reported rare soft-tissue tumor that can develop in various sites including orbit. Orbital GCAs were mainly located in the eyelid or extraconal regions such as lacrimal gland and conjunctiva. We report an atypical case of a GCA arising in the intraconal area of the orbit in a 65-year-old male patient. The tumor was excised in total by lateral orbitotomy. Histological and immunohistochemical features were consistent with the diagnosis of GCA. No recurrence was observed during the follow-up of over 2 years...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29283124/topical-chemotherapy-for-giant-ocular-surface-squamous-neoplasia-of-the-conjunctiva-and-cornea-is-surgery-necessary
#17
Sonal S Chaugule, Jennifer Park, Paul T Finger
PURPOSE: The purpose of this study is to report on the efficacy and safety of topical chemotherapy alone for giant ocular surface squamous neoplasia (OSSN). METHODS: In this retrospective, interventional series, 10 eyes with giant OSSN underwent exfoliative biopsy to confirm the diagnosis followed by application of interferon alpha 2b (IFN α2b) and/or 5 fluorouracil, 1% (5FU). Reported outcome measures were tumor response, visual acuity, recurrence, systemic metastasis, and treatment complications...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29280702/effective-management-of-extensive-tissue-loss-after-abdominoperineal-resection-for-buschke-loewenstein-tumor
#18
G Balducci, G Carbotta, M G Sederino, A Delvecchio, R Laforgia, P Sallustio, P Lobascio, F Ferrarese, M Minafra, S Fedele, N Palasciano
The giant condyloma acuminatum or Buschke-Loewenstein tumor is a rare, sexually transmitted disease. It is an epithelial tumor characterized by its high potential of malignancy towards developing into a highly invasive squamous cell carcinoma. The present case concerns a drug addicted 40-year-old man who smuggled drugs using his rectum. He had a partially ulcerated mass in the perianal area of about 20 x 10 cm. He reported a progressive growth of this neoplasm during the last 3 years associated with perianal pain, obstructed defecation, bad sitting posture, no fever and weight loss...
September 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29279827/parotid-mandibular-bone-defect-a-case-report-emphasizing-imaging-features-in-plain-radiographs-and-magnetic-resonance-imaging
#19
Miki Hisatomi, Luciana Munhoz, Junichi Asaumi, Emiko Saito Arita
Mandibular bone depression, also known as Stafne bone cavity, is defined as a bone depression filled mainly with salivary gland tissue. Parotid gland bone defects are infrequently observed. We report the case of a 52-year-old male patient who underwent radiographic examinations due to temporomandibular joint dysfunction, and a radiolucent area was detected in the mandibular ramus, with a provisional diagnosis of traumatic bone cyst or parotid mandibular bone defect. The patient was then referred for magnetic resonance imaging, which demonstrated a hyperintense area eroding the mandibular ramus, which corresponded to glandular tissue...
December 2017: Imaging Science in Dentistry
https://www.readbyqxmd.com/read/29279564/a-case-of-a-giant-cell-tumor-of-the-tendon-sheath-of-the-middle-phalanx-of-the-fourth-toe
#20
Kyochika Okabe, Toshihiko Hoashi, Mariko Asahara, Eiko Esaki, Michiko Ito, Rui Otsuka, Yoko Funasaka, Hidehisa Saeki
Giant cell tumors of the tendon sheath (GCT-TS) are one of the most common tumors of the hand, along with ganglions. However, occurrence in the toes is far less common. Here we present a rare case of GCT-TS at the middle phalanx level of the flexor digitorum longus tendon sheath. Magnetic resonance imaging showed low intensity both on T1 and T2 weighted images. To the best of our knowledge, our case is the first report of a GCT-TS arising at the middle phalanx level of the flexor digitorum longus tendon sheath of the fourth toe...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
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