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Giant cell tumor

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https://www.readbyqxmd.com/read/28816971/combining-of-serial-embolization-and-denosumab-for-large-sacropelvic-giant-cell-tumor-case-report-of-3-cases
#1
Tao Ji, Yi Yang, Yifei Wang, Kunkun Sun, Wei Guo
RATIONALE: Both serial arterial embolization (SAE) and denosumab have been proved to be effective in treatment for giant cell tumor (GCT). There is potential synergic effect of combining two methods. The purpose of current study is to justify a new treatment strategy of combination of SAE and denosumab as neoadjuvant or stand-alone treatment for large sacropelvic giant cell tumor. PATIENT CONCERNS: Pelvic and sacral GCTs tend to be very large size and vascular. The concerns of surgical treatment were invasiveness of extensive surgery, intraoperative hemorrhage, nerve function jeopardized and local recurrence...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816553/a-rare-case-of-giant-multicystic-solitary-fibrous-tumor-of-the-orbit
#2
Shahid Alam, Varsha Backiavathy, Bipasha Mukherjee, Krishnakumar Subramanian
Solitary fibrous tumor (SFT) is a rare spindle cell tumor of the orbit of mesenchymal origin. Though these tumors are mostly solid, partial or complete cystic changes can rarely occur. Only six such previous cases of cystic fibrous tumor of the orbit have been mentioned in the literature. We report a case of an elderly male who presented with a huge left sided medial orbital mass. Magnetic resonance imaging showed a predominant cystic orbital mass separated by septae and suggested a diagnosis of Hydatid cyst...
August 17, 2017: Orbit
https://www.readbyqxmd.com/read/28801376/cellular-blue-nevus-of-perilimbal-conjunctiva-a-case-report-and-review-of-literature
#3
Tiangeng He, Chunjie Mao, Dongbo Xu, Hua Yan
Cellular blue nevus is an uncommon neoplasm in the conjunctiva. Here we present an unusual case of a cellular blue nevus that clinically resembled conjunctival melanoma. A 29-year-old Chinese male was found to have a giant pigmented lesion of the conjunctiva around the limbal area of right eye from birth. Excisional biopsy with no-touch technique, lamellar corneal transplantation, amniotic membrane transplantation and adjuvant cryotherapy were performed. Histopathology revealed a nodular, well-defined tumor, which was composed of heavily pigmented dendritic cells and less pigmented spindle cells...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28797989/giant-pancreatic-solid-cystic-desmoid-tumor-with-two-ectopic-adrenal-tissues
#4
Neşe Ekinci, Fikret Dirilenoğlu, Arzu Avcı, Oğuzhan Özsay
A 19-year-old woman presented with painless swelling of the abdomen. During surgery, a giant mass measuring 37 cm×26 cm×12 cm within the distal pancreas invading the spleen was noted. The clinical diagnosis of a solid cystic pseudopapillary tumor of the pancreas was suspected. Distal pancreatectomy, splenectomy, and debulking surgery were performed. Histological examination showed that the tumor infiltrated the spleen and pancreatic parenchyma, and sections of the solid areas revealed a proliferation of spindle-shaped or stellate cells growing in fascicular and storiform patterns within a myxoid intercellular matrix...
August 9, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28797502/giant-cell-containing-tumors-of-bone
#5
REVIEW
Zsolt Orosz, Nicholas A Athanasou
Giant cell-containing tumors of bone are characterized morphologically by the presence of numerous osteoclastic giant cells. Correlation of clinical, radiologic, and laboratory findings is required for accurate histopathologic diagnosis and treatment of a giant cell-containing tumor of bone. In differential diagnosis, it is particularly important to note the age of the patient and the skeletal location of the lesion. This article considers the range of neoplastic and nonneoplastic lesions, which histologically contain numerous osteoclastic giant cells, and focuses on several lesions that frequently enter into the differential diagnosis...
September 2017: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/28794862/case-report-an-incidentaloma-that-catches-your-eye-adrenal-myelolipoma
#6
Rosanna D'Addosio, Joselyn Rojas, Valmore Bermúdez, Flor Ledesma, Kyle Hoedebecke
Background: Adrenal incidentaloma refers to the incidental finding of a tumor in the adrenal gland, where nonfunctional forms are the most common variant. Myelolipoma is a rare (0.08-0.4%) occurrence characterized by adipose and hematopoietic tissue. The aim of this case report is to describe the diagnosis and appropriate management of a myelolipoma in an asymptomatic patient, which was originally considered an incidental hepatic hemangioma prior to being identified as a giant adrenal adenoma. Case description: The patient was a 54 year old obese female with a recent diagnosis of diabetes type II and dyslipidemia with recent ultrasound imaging suggestive of a hepatic hemangioma...
2017: F1000Research
https://www.readbyqxmd.com/read/28791997/-eosinophilic-granuloma-of-the-parietal-bone-of-an-adult-patient-with-braf-mutation
#7
O V Dolzhansky, E M Paltseva, A A Bukaeva, E V Zaklyazminskaya, I A Spivak, D N Fedorov
The paper describes a case of eosinophilic granuloma of the parietal bone in a 32-year-old man. Histological examination revealed a large number of bean-shaped Langerhans cell histiocytes with lobed nuclei and nuclear grooves. The histiocytes alternated with the foci of obvious eosinophilic infiltration and with eosinophilic microabscesses. There were osteoclast-like multinucleated giant cells, bone resorption, and numerous bone rods covered with osteoblast chains. The histiocytes expressed CD1α, langerin, CD68, S100, and p53 (in 90...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28782699/does-curettage-cement-packing-for-treating-giant-cell-tumors-at-the-knee-lead-to-osteoarthritis
#8
A Caubère, S Harrosch, M Fioravanti, G Curvale, A Rochwerger, J C Mattei
INTRODUCTION: Giant cell tumors (GCTs) make up 15% to 20% of bone-related tumors in adults. They are often found around the knee in the metaphysis and epiphysis area, contacting the joint cartilage. The aims of our study were to evaluate the presence of early knee osteoarthritis (OA) in patients with GCTs in the knee area treated by curettage-cement packing, and to evaluate whether replacing subchondral bone with acrylic cement has an effect on the functional outcomes and quality of life...
August 3, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28778029/papillotubular-carcinoma-with-an-invasive-micropapillary-carcinoma-component-of-the-breast-characterized-by-a-rapid-increase-in-size-due-to-intra-tumoral-hemorrhage-a-case-report
#9
Motonobu Watanabe, Ryota Matsuoka, Yukako Ichimura, Toshiro Takagaki, Yasushi Iitsuka
INTRODUCTION: Rapidly enlarging mammary tumors, including invasive breast tumors, are clinically rare. Invasive micropapillary carcinoma (IMPC) of the breast is known to have aggressive behavior and poor clinical course compared to invasive ductal carcinoma. CASE PRESENTATION: An 87-year-old woman presented with a rapidly enlarging tumor of the right breast over the course of 3 weeks. Ultrasonography and computed tomography of the chest revealed a giant tumor located on the right chest wall, with heterogeneous parenchymal components and several cystic lesions...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28767598/giant-liver-hemangioma-with-adult-kasabach-merritt-syndrome-case-report-and-literature-review
#10
Xiaolei Liu, Zhiying Yang, Haidong Tan, Li Xu, Yongliang Sun, Shuang Si, Liguo Liu, Wenying Zhou, Jia Huang
RATIONALE: Adult Kasabach-Merritt syndrome associated with giant liver hemangioma is rare; to date, most reports have been single-case reports, and no multi-case reports or literature reviews are available. DIAGNOSES: We conducted a retrospective analysis of 5 cases of adult Kasabach-Merritt syndrome associated with giant liver hemangioma treated at our hospital between 2011 and 2016. All 5 patients had varying severities of leukopenia, anemia, thrombocytopenia, prolonged prothrombin time, and hypofibrinogenemia...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28765257/tenosynovial-giant-cell-tumor-incidence-prevalence-patient-characteristics-and-recurrence-a-registry-based-cohort-study-in-denmark
#11
Vera Ehrenstein, Søren L Andersen, Ibrahim Qazi, Neil Sankar, Alma B Pedersen, Robert Sikorski, John F Acquavella
OBJECTIVE: Tenosynovial giant cell tumor (TGCT) is a rare benign proliferative and inflammatory disease arising from synovia of joints, bursae, or tendon sheaths. We aimed to estimate incidence rate and prevalence of TGCT in Denmark, to describe patient characteristics and treatment modalities among patients with TGCT, and to estimate risk of TGCT recurrence. METHODS: Using registry data on pathology examinations and inpatient and outpatient hospital diagnoses, we identified adult patients with diagnoses of diffuse TGCT (D-TGCT) or localized TGCT (L-TGCT) between 1997 and 2012, followed through 2012...
August 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28761843/well-differentiated-squamous-cell-carcinoma-presenting-as-branched-eyelid-cutaneous-horn-a-case-report-with-review-of-literature
#12
Rakhi Kusumesh, Anita Ambastha, Bhadrapriya, Sanjeet Singh
Cutaneous horns are uncommon lesions consisting of keratotic material, resembling that of an animal horn. They account for 4% of all eyelid tumors. We report a case of giant cutaneous horn (2 × 1.75 cm) of 4-year duration arising from the right lower lid. Growth excision with direct closure of the defect was done. Histopathological examination revealed it to be well-differentiated squamous cell carcinoma. Most important concern while evaluating cutaneous horns is the underlying condition, which may be benign or malignant...
July 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28756986/extraskeletal-aneurysmal-bone-cyst-report-of-a-case-and-review-of-the-literature
#13
Liurka V Lopez, Michael G Rodriguez, Gene P Siegal, Shi Wei
Aneurysmal bone cyst (ABC) is an expansile cystic lesion that may affect any bone of the skeleton. Although exceedingly rare, lesions with histomorphologic characteristics of an ABC have reportedly originated within soft tissue. Extraskeletal ABC may mimic a variety of benign and malignant lesions and can be confused with other more common or rare giant cell-rich tumors of soft tissue, especially myositis ossificans. Clinical, radiological and histologic correlation is crucial in reaching the correct diagnosis...
July 6, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28750392/giant-cell-tumor-of-bone-and-other-giant-cell-rich-lesions
#14
(no author information available yet)
No abstract text is available yet for this article.
2017: Monographs in Clinical Cytology
https://www.readbyqxmd.com/read/28748250/-disseminated-osteolytic-lesions-in-a-28-year-old-refugee
#15
T Karrasch, H D Walmrath, M Kampschulte, D Steiner, W Seeger, W Padberg, U Sibelius, S Gattenlöhner, A Schäffler
A 28-year-old Syrian refugee presented with right-sided knee pain and progressive deterioration of the general condition over the past months. Laboratory diagnostics revealed severe hypercalcemia due to primary hyperparathyroidism, and computed tomography (CT) scanning demonstrated disseminated osteolytic lesions throughout the skeleton. Histologically, these lesions were characterized by multinuclear giant cells (defining these lesions as so-called brown tumors). Finally, surgical removal of a jugular mass allowed the histopathologic diagnosis of a sporadic parathyroid carcinoma...
July 26, 2017: Der Internist
https://www.readbyqxmd.com/read/28747182/recurrent-primary-mediastinal-giant-cell-tumor-of-soft-tissue-with-radiological-findings-a-rare-case-report-and-literature-review
#16
Qiongjie Hu, Jian Peng, Liming Xia
BACKGROUND: Giant cell tumor of soft tissue (GCT-ST), which histologically resembles GCT of bone, is a rare tumor. Usually, it is located in the lower extremities and trunk. GCT-ST, occurring in mediastinum, is extremely rare. CASE PRESENTATION: We encountered an 18-year-old Chinese woman who had mild dull pain on the left side of back. The following chest computed tomography (CT) showed a heterogeneous mass deeply situated in the posterior mediastinum with compression of the lung and invasion of the adjacent rib...
July 26, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28737756/overexpression-of-zinc-finger-protein-687-enhances-tumorigenic-capability-and-promotes-recurrence-of-hepatocellular-carcinoma
#17
T Zhang, Y Huang, W Liu, W Meng, H Zhao, Q Yang, S-J Gu, C-C Xiao, C-C Jia, B Zhang, Y Zou, H-P Li, B-S Fu
Zinc finger protein 687 (ZNF687), identified as a C2H2 zinc finger protein, has been found to be mutated and upregulated in giant cell tumor of bone and acute myeloid leukemia, suggesting an oncogenic role for ZNF687 in cancer. However, the clinical significance and precise role of ZNF687 in cancer progression are largely unknown. Herein, we report that ZNF687 was markedly upregulated in hepatocellular carcinoma (HCC) cell lines and HCC tissues, and was significantly correlated with relapse-free survival in HCC...
July 24, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28732103/denosumab-current-use-in-the-treatment-of-primary-bone-tumors
#18
Olga D Savvidou, Ioanna K Bolia, George D Chloros, John Papanastasiou, Panagiotis Koutsouradis, Panayiotis J Papagelopoulos
Denosumab, a human monoclonal antibody that inhibits bone resorption by binding on the receptor activator of the nuclear factor kappa-β ligand, has recently emerged as an additional option in the treatment of musculoskeletal osteolytic tumors. This article focuses on the recent literature regarding the effectiveness of denosumab in the management of giant cell tumor, multiple myeloma, aneurysmal bone cyst, and osteosarcoma. The mechanism of action of denosumab in the management of these tumors and the associated side effects are discussed in detail...
July 1, 2017: Orthopedics
https://www.readbyqxmd.com/read/28730250/metastatic-high-grade-myxofibrosarcoma-review-of-a-clinical-case
#19
Tiberiu Paul Neagu, Ruxandra Diana Sinescu, Valentin Enache, Sanda Claudia Achim, Mirela Ţigliş, Liliana Elena Mirea
We present the particular clinical and histological features of a metastatic high-grade myxofibrosarcoma (MFS) of the left buttock in a 77-year-old male patient. The tumor was biopsied and surgically removed in order to increase the patient's comfort, due to its increased size and aggressive clinical behavior. Computed tomography (CT) revealed metastases in the pleura and mediastinal lymph nodes, so limb-sparing tumor excision followed by palliative care was the best practice for the patient until the fatal outcome...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28728303/-enhancing-soft-tissue-reattachment-with-artificial-mesh-in-joint-endoprosthetic-reconstruction-for-bone-tumors
#20
J S Lin, R Chen, W Yan, D D Chen
Objective: To investigate the operative method and clinical application of the BARD(®) Mesh in enhancing joint stability and function of endoprosthetic reconstruction for bone tumors. Methods: From Jan 2013 to Jun 2015, the clinical data of 51 patients aged (44.75±23.18) years underwent wide resection of tumor and endoprosthetic reconstruction using the BARD(®) Mesh were collected. Among them, 27 were male and 24 were female. The surgical treatments received by these patients included 5 shoulder arthroplasties, 12 elbow replacements, 12 hip replacements and 32 knee replacements (including 24 femoral tumors and 8 tibial tumors)...
July 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
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