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Giant cell tumor

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https://www.readbyqxmd.com/read/29773427/microphthalmia-associated-transcription-factor-mitf-promiscuous-staining-patterns-in-fibrohistiocytic-lesions-is-a-potential-pitfall
#1
Sambit K Mohanty, Shivani Sharma, Dinesh Pradhan, Shivani R Kandukuri, Navid Farahani, Catherine Barry, Julie M Wu, David Frishberg, Bonnie Balzer
Microphthalmia-associated transcription factor (MiTF) is used as a marker of melanocytic differentiation. However, MiTF immunoexpression has also been observed in histiocytes, macrophages, smooth muscle cells and fibroblasts, which raise the concern of fibrohistiocytic (FH) lesions being misdiagnosed as melanoma based on MiTF immunoreactivity. MiTF has been known to be positive in FH tumors, but this is the first study evaluating ninety-three fibrohistiocytic neoplasms to understand and delineate the staining pattern of MiTF in these tumors...
May 11, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29772865/-diffuse-type-tenosynovial-giant-cell-tumor-of-the-gluteus-maximus-muscle-a-case-report
#2
Long Chen, Long-Long Lyu, Hao Lyu, Qi Huang, Sheng-Ming Xu, Feng Niu
No abstract text is available yet for this article.
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29772366/giant-cell-ependymoma-of-cervical-medullary-junction-a-case-report-of-a-long-term-survivor-and-review-of-literature
#3
REVIEW
Martina Cappelletti, Andrea G Ruggeri, Giorgia Iacopino, Roberto Delfini
Ependymoma accounts for 3-9% of all neuroepithelial tumors. The giant cell ependymoma is a rare and distinct variant, of which only twenty-two cases have been described in literature. Starting from 2007, the WHO acknowledged this rare subtype. The cytological features of GCE are the presence of pleomorphic giant cells with several cellular atypias, which at intra-operative frozen diagnosis may appear to be high-grade glial lesions. Despite its apparently malignant histology, GCE seems to be a neoplasm with a relatively good prognosis...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29771825/complex-scalp-and-calvarium-defects-after-giant-basal-cell-carcinoma-excision-management-challanges-outcomes
#4
Utku Ozcan, Mustafa Akyurek, Emrah Arslan
Giant basal cell carcinoma (GBCC) is defined as a tumor ≥5 cm in diameter. GBCC of scalp usually requires extended resection of soft tissues, calvarium, and dura. In this study, we present 5 patients with GBCC of head, who underwent a single-stage combined scalp, calvarium, and dural reconstruction. Herein, we aim to discuss reconstruction methods, cerebrospinal fluid (CSF) leakage, duration of hospital stay, and tumor recurrency. Peroperative and postoperative follow-ups, defect areas, and performed calvarium reconstruction methods of 5 patients, who underwent complex scalp and calvarium reconstruction after GBCC between year 2010 and 2017, were retrospectively maintained...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29771688/plexiform-atypical-spitz-tumor-with-rosette-like-giant-cells-a-histologic-and-immunohistochemical-study-on-a-case-suggesting-ganglioneuroblastic-differentiation-review-of-the-literature-and-considerations-on-histogenesis
#5
Elena Castelli, Elisabetta Orlando, Giuseppe Pistone, Maria R Bongiorno
Spitz nevi, atypical Spitz tumors and Spitzoid melanoma, the three clinicopathologic forms that constitute the spectrum of the Spitz-type melanocytic lesions, share a histologic picture characterized by large spindle and/or epithelioid ganglion-like cells, with various admixtures of multinucleate bizarre cells. This remarkable cytology has always been interpreted as an unusual, as well as unexplained form of atypia. We report a case of atypical Spitz tumor with Homer Wright-like rosettes, a feature characteristic of ganglioneuroblastic proliferation...
May 16, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29768375/total-spondylectomy-of-recurrent-giant-cell-tumors-in-the-cervical-spine-two-case-reports-and-review-of-literature
#6
Ji Tu, Wentian Li, Shenglei Shu, Yukun Zhang, Wenbin Hua, Shuai Li, Shuhua Yang, Cao Yang
RATIONALE: Spinal Giant Cell Tumors (SGCTs) are rare, aggressive, and benign tumors. Their presence in the cervical spine is even more exceptional. There are few reports of cervical GCT in the literature, especially recurrent cases. The treatment are challenging to clinically because radical resection is extremely difficult. PATIENT CONCERNS: In this study, we present the cases of a 25-year-old man and a 41-year-old woman who suffered from recurrent cervical GCT...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29766265/surgery-for-subependymal-giant-cell-astrocytomas-in-children-with-tuberous-sclerosis-complex
#7
Martine Fohlen, Sarah Ferrand-Sorbets, Olivier Delalande, Georg Dorfmüller
OBJECTIVE: Subependymal giant cell astrocytomas (SEGAs) are low-grade intraventricular glial tumors that develop in 10-15% of patients with tuberous sclerosis complex; they often cause hydrocephalus and are potentially accessible to a surgical treatment. Our aim is to evaluate morbidity and results after surgery in symptomatic and asymptomatic patients. METHOD: We present a retrospective series of 18 pediatric patients operated on for SEGA between 2006 and 2016 at our institution...
May 15, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29764791/giant-cell-tumor-of-the-temporal-bone-and-skull-base-a-case-report
#8
İsa Kaya, Murat Benzer, Göksel Turhal, Gode Sercan, Cem Bilgen, Tayfun Kirazlı
Giant cell tumor (GCT) is a benign tumor that originates from undifferentiated mesenchymal cells of the bone marrow. The cranium as well as temporal bone is a rare location for GCTs. Despite its benign nature, GCT may be locally aggressive and has the potential to recur locally. Furthermore, GCT may give rise to pulmonary metastases (~1%) in addition to causing local bone destruction. Surgical excision is the treatment of choice for patients with GCT. We describe the case of a 56-year-old female who presented with headache and hearing loss with extensive GCT, which originated in the squamous part of the temporal bone and extended into the left mandibular fossa and middle ear...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29760872/giant-morphea-form-basal-cell-carcinoma-of-the-umbilicus-successful-debulking-with-vismodegib
#9
Mariana Orduz Robledo, Eve Lebas, Marie-Annick Reginster, Mahmoud Baghaie, Sabine Groves, Arjen F Nikkels
Basal cell carcinoma of the umbilicus is very rare. The nodular subtype is the main representative. Giant basal cell carcinomas represent around 1% of all basal cell carcinomas. The hedgehog pathway inhibitor vismodegib is indicated for advanced basal cell carcinoma and CD56-negative immunostaining seems indicative for successful treatment. A 54-year-old man presented a 10 cm × 14 cm large and 4.5 cm deep morphea-form basal cell carcinoma with faint immunohistochemical CD56 expression arising from the umbilicus...
2018: Rare Tumors
https://www.readbyqxmd.com/read/29757500/immunohistochemistry-for-histone-h3g34w-and-h3k36m-is-highly-specific-for-giant-cell-tumor-of-bone-and-chondroblastoma-respectively-in-fna-and-core-needle-biopsy
#10
Inga-Marie Schaefer, Jonathan A Fletcher, G Petur Nielsen, Angela R Shih, Marco L Ferrone, Jason L Hornick, Xiaohua Qian
BACKGROUND: Diagnosing giant cell-rich bone tumors can be challenging on limited biopsies. H3 histone family member 3A (H3F3A) (G34W/V/R/L) mutations are present in the majority of giant cell tumors (GCTs) of bone and H3 histone family member 3B (H3F3B) (K36M) mutations are present in nearly all chondroblastomas, but are absent in histologic mimics. Mutation-specific immunohistochemistry (IHC) is highly specific for GCT and chondroblastoma in surgical excisions. The objective of the current study was to validate H3G34W and H3K36M IHC in the diagnosis of giant cell-rich bone tumors on fine-needle aspiration and core needle biopsy specimens...
May 14, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29755092/-two-stage-surgery-for-uterine-intravenous-leiomyomatosis-with-right-ventricular-extension-report-of-a-case
#11
Tomoya Fukui, Koji Kawahito, Akira Sugaya, Keisuke Shimizu, Kei Aizawa, Yoshio Misawa
Intravenous leiomyomatosis is a rare neoplastic condition characterized by the benign intravascular proliferation of smooth muscle cells originating from either the uterine venous wall or a uterine leiomyoma. In the present report, we describe the case of a 36-year-old woman, who was referred to our institution due to abdominal pain. Computed tomography indicated the presence of a giant intravenous leiomyoma originating from the uterus and extending to the right ventricle with complex pathways. The patient was successfully treated by tumor resection under circulatory arrest in two-stage operations in conjunction with gonadotrophin-releasing hormone agonists therapy...
May 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29753697/giant-dentinogenic-ghost-cell-tumor-a-case-report
#12
Ciro Dantas Soares, Roman Carlos, Thayná Melo de Lima Morais, Oslei Paes de Almeida
Dentinogenic ghost cell tumor (DGCT), a rare, benign odontogenic tumor with aggressive behavior, causes bone destruction and cortical expansion. We report here a case of DGCT in a 38-year-old male, presenting with enormous extraoral protrusion, which radiographically was predominantly radiolucent with radiopaque areas. Microscopically, it was observed to be a solid ameloblastomatous proliferation with pseudoglandular structures associated with clusters of ghost cells. Abundant dentinoid material adjacent to the epithelial sheets containing entrapped epithelial tumor cells was also evident...
April 18, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29749998/morphological-and-immunohistochemical-diversity-of-endometrial-stromal-sarcoma-in-rats
#13
Shino Kumabe, Junko Sato, Yuki Tomonari, Miwa Takahashi, Kaoru Inoue, Midori Yoshida, Takuya Doi, Yumi Wako, Minoru Tsuchitani
To clarify the histopathological characteristics of rat endometrial stromal sarcoma (ESS), we morphologically reviewed 12 malignant uterine tumors protruding into the lumen in previous rat carcinogenicity studies. The 12 cases were classified into the following 6 types based on their morphological features: spindle cell and collagen rich type, pleomorphic/spindle cell and compact type, decidual alteration type, histiocytic and multinucleated giant cell mixture type, Antoni A-type schwannoma type, and Antoni B-type schwannoma type...
April 2018: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29745092/therapeutic-benefits-of-neoadjuvant-and-post-operative-denosumab-on-sacral-giant-cell-tumor-a-retrospective-cohort-study-of-30-cases
#14
Zhongyan Chen, Yi Yang, Wei Guo, Rongli Yang, Xiaodong Tang, Taiqiang Yan, Tao Ji, Lu Xie, Jie Xu, Jun Wang
PURPOSE: Denosumab, a new monoclonal antibody that inhibits receptor activator for nuclear factor Kβ ligand (RANKL), has recently been approved by FDA for the treatment of aggressive giant cell tumor of bone (GCTB). So we initiated this study to evaluate the clinical benifits of denosumab used preoperatively or postoperatively. METHODS: Patients diagnosed with classic sacral GCT without metastasis were included in this study. Patients were assigned into 3 groups according to the use of denosumab: control group 1, post-operative group 2 and neoadjuvant group 3...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29742594/capillary-hemangioma-as-an-unusual-cause-of-doughnut-sign-on-bone-scan
#15
Omar Q Samarah, Mohammad I Tayyem, Nisreen Abu Shahin, Ghadeer AlMuhaisen, Malik E Juweid
A 28-year-old woman presented with a mass in her right leg, which, on plain radiograph, appeared as a lytic lesion in the mid-shaft of the tibia with cortical thinning but without periosteal reaction. Tc-MDP 3-phase bone scan demonstrated intense uptake in the periphery of the mass with a photopenic center, the so-called doughnut sign. Histopathology revealed a capillary hemangioma. This case demonstrates that the doughnut sign on bone scan can be caused by capillary hemangioma in addition to other reported bone pathologies, including aneurysmal bone cyst, giant cell tumor, and telangiectatic osteosarcoma...
May 7, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29741702/prognosis-of-metastatic-giant-cell-tumor-of-bone-in-the-pre-denosumab-era-a-systematic-review-and-a-meta-analysis
#16
Boris Itkin, Samanta Straminsky, Gabriela De Ronato, Daniel Lewi, Adolfo Marantz, Ariel Bardach
Background: Data on long-term prognosis of metastatic GCT (mGCT) is scant. The frequency of spontaneous regressions (SRs) is unknown. We aimed to estimate the prognosis of mGCT. Methods: We searched electronic scientific literature databases and generic Internet from January 1980 to August 2017. After identifying eligible studies we performed descriptive analyses and meta-analyses to estimate overall survival (OS), disease specific survival (DSS) and frequency of SRs in the years before the widespread use of denosumab...
May 5, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29738344/giant-cell-tumor-of-the-ribs-and-aneurysmal-bone-cyst-presenting-with-hemothorax-in-a-child-erratum
#17
(no author information available yet)
No abstract text is available yet for this article.
May 4, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29737103/-therapeutic-effect-of-uncemented-allograft-prosthetic-composite-for-the-reconstruction-of-tumorous-bone-defect
#18
Yan-Ling Wang, Li Min, Hong Duan, Yong Zhou, Wei-Li Zhang, Rui Shi, Yi Luo, Chong-Qi Tu
OBJECTIVE: To investigate the surgical techniques and mid-term efficacy of reconstruction for proximal femur with allograft-prosthetic composite (APC) . METHODS: Fifteen patients who underwent uncemented APC reconstruction of proximal femur after bone tumor resection were retrospectively evaluated. Image and physical examinations were taken on the 1st,3rd,6th,9th and 12th month after surgery and every 6 months thereafter to assess union condition,greater trochanteric bone absorption and myodynamia of abductors...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29736285/nonsmall-cell-lung-carcinoma-with-giant-cell-features-expressing-programmed-death-ligand-1-a-report-of-a-patient-successfully-treated-with-pembrolizumab
#19
Shingo Nakayama, Mamoru Sasaki, Shojiroh Morinaga, Naoto Minematsu
Giant cell carcinoma, a rare variant of nonsmall cell lung carcinoma (NSCLC), is characterized by aggressive progression and poor response to conventional chemotherapy. This report is the first to describe a patient with NSCLC and giant cell features who was successfully treated with pembrolizumab, an antibody targeting programmed death-1 (PD-1). A 69-year-old woman was diagnosed with NSCLC with multiple brain metastases. Histological evaluation of lung biopsy specimens revealed proliferation of pleomorphic giant tumor cells with poor cohesiveness, findings consistent with giant cell carcinoma...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29734913/vascularized-iliac-bone-lining-in-downgraded-treatment-of-campanacci-grade-iii-giant-cell-tumor-of-the-distal-radius
#20
Kazufumi Sano, Kazumasa Kimura, Satoru Ozeki
It is commonly accepted that wide en bloc resection followed by reconstruction is essential in progressive lesions (Campanacci grade III) for local control of possible recurrence. However, specific grade III can be downgraded and treated with intralesional curettage to preserve better wrist function, without increasing the recurrency rates. In this report, Grade III giant cell tumor of the distal radius was successfully treated using vascularized osseous graft from the inner lip of the iliac bone in addition to downgrading strategy...
June 2018: Journal of Hand Surgery Asian-Pacific Volume
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