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https://www.readbyqxmd.com/read/28217683/lymphoepithelioma-like-carcinoma-of-the-uterine-cervix
#1
Hyun Sil Yun, Sun Kyung Lee, Gun Yoon, Hwi Gon Kim, Dong Hyung Lee, Yong Jin Na, Ook Hwan Choi, Dong Hoon Shin, Yong Jung Song
Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is exceedingly uncommon. We herein report a rare case of cervical LELC. A 45-year-old woman was admitted to gynecology department with vaginal bleeding for one month. Liquid-based cytology revealed atypical endometrial cells, not otherwise specified on her cervix. On a hysteroscopy, an endocervical mass was identified and the pathologic result was consistent with poorly differentiated squamous cell carcinoma. Magnetic resonance imaging and positron emission tomography with 2-deoxy-2-[fluorine-18] fluoro-D-glucose integrated with computed tomography revealed a 3...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28217670/a-novel-clinicopathological-analysis-of-early-stage-ovarian-sertoli-leydig-cell-tumors-at-a-single-institution
#2
Seon Mi Nam, Jee Whan Kim, Kyung Jin Eoh, Hye Min Kim, Jung Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Young Tae Kim
OBJECTIVE: To evaluate the clinical and pathologic characteristics of patients who were diagnosed with ovarian Sertoli-Leydig cell tumors (SLCTs) in a single institution. METHODS: The medical records of 11 patients who were pathologically diagnosed with SLCTs beginning in 1995 in a single institute was reviewed. RESULTS: The median patient age was 31 years (range, 16 to 70 years). Patient International Federation of Gynecology and Obstetrics stages were IA, IC, and IIB in 3 (27...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28211234/lymphoepithelioma-like-carcinoma-of-cervix-cytological-features-on-conventional-cervical-smear
#3
Ruchi Rathore, Vinod K Arora, Bharat Singh
Lymphoepithelioma-like carcinoma (LELC) is a rare neoplasm of the cervix. The importance of distinguishing this undifferentiated carcinoma with a predominant lymphocytic infiltrate lies in the fact that despite being poorly differentiated they have a better prognosis. The diagnosis however becomes more challenging when the pathologist is provided with a small cervical biopsy or a Papanicolaou smear. While the reports describing histology and their relation to Epstein-Barr virus (EBV) are many, there are only few case reports describing the cytology of these tumors...
March 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28202851/expression-of-inorganic-pyrophosphatase-ppa1-correlates-with-poor-prognosis-of-epithelial-ovarian-cancer
#4
Hui Li, Ning Xiao, Zongpeng Li, Qin Wang
Ovarian serous carcinoma (OSC) is the most common epithelial ovarian cancer. Inorganic pyrophosphatase (PPA1) catalyzes the hydrolysis of pyrophosphate to inorganic phosphate, thereby providing extra energy for metabolism. The significance of PPA1 in the prognosis of OSC has not been investigated. Our study aimed to explore the expression and predictive role of PPA1 in OSC progression. We screened the expression of PPA1 protein in OSC tissues from 139 patients by immunohistochemistry, and evaluated its correlation with clinicopathological characteristics...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28190981/the-role-of-intraperitoneal-carboplatin-as-consalidation-chemotherapy-in-women-with-ovarian-carcinoma-report-of-our-experience-and-systematic-review
#5
Azamsadat Mousavi, Mojgan Karimi-Zarchi, Nadere Behtash, Mitra Modares-Gilani, Mahnaz Mokhtari-Gorgani, Nili Mehrdad, Mitra Rouhi, Pouria Yazdian Anari
BACKGROUND: Epithelial ovarian cancer is the leading cause of death from gynecology malignancy. The aim of this study was to assess the role of intraperitoneal chemotherapy with carboplatin, as a consolidative treatment, in reducing relapse and increasing survival of patients in advanced epithelial ovarian cancers, as well as evaluation of its toxicity. METHODS: This clinical trial was conducted on 30 patients with epithelial ovarian cancer in stages II-IV in Gynecology oncology department in Valiasr University Hospital, Tehran during 2005-2010...
December 2016: International Journal of Biomedical Science: IJBS
https://www.readbyqxmd.com/read/28187099/serous-tubal-intraepithelial-carcinoma-associated-with-extraovarian-metastases
#6
Stephanie Schneider, Sebastian Heikaus, Philipp Harter, Florian Heitz, Christoph Grimm, Beyhan Ataseven, Sonia Prader, Christian Kurzeder, Thomas Ebel, Alexander Traut, Andreas du Bois
OBJECTIVE: The evolving knowledge of ovarian carcinogenesis sets the stage for our understanding of high-grade serous pelvic carcinoma (HGSC). Findings in prophylactic surgery introduced serous tubal intraepithelial carcinoma (STIC) as potential precursor of HGSC. The present study explores whether STIC instead should already be considered as an early stage of HGSC with a need for comprehensive staging and therapy. PATIENTS AND METHODS: We identified all consecutive patients with HGSC who received first-line therapy in our referral center for gynecologic oncology from January 2011 to April 2016...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28187097/agreement-between-preoperative-endometrial-sampling-and-surgical-specimen-findings-in-endometrial-carcinoma
#7
Tiago Selbach Garcia, Márcia Appel, Raquel Rivero, Lúcia Kliemann, Maria Celeste Osório Wender
OBJECTIVES: The aims of the study were to evaluate agreement between preoperative endometrial samples and surgical specimens in endometrial carcinoma and to correlate this agreement with sample and patient characteristics. METHODS: Patients who received primary surgical treatment for endometrial carcinoma at a tertiary care center and had undergone preoperative endometrial sampling were included. Medical records were reviewed to collect information from pathology reports and data on patient characteristics...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28178620/mir-944-acts-as-a-prognostic-marker-and-promotes-the-tumor-progression-in-endometrial-cancer
#8
Zhonghui He, Hong Xu, Yugang Meng, Yan Kuang
microRNA-944 (miR-944) has been reported to be deregulation and play either tumor suppressive or oncogenic function in human malignancies. Previous studies have reported that miR-944 is overexpressed in gynecological malignancies including cervical cancer and breast cancer. While, the clinical significance of miR-944 and its function in human endometrial carcinoma (EC) keep unknown. The levels of miR-944 were analyzed in 68 EC tissues and 20 normal endometrial tissues. Results showed that miR-944 was significantly overexpressed in EC tissues compared to normal endometrial tissues...
February 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28161495/should-the-presence-of-metastatic-para-aortic-lymph-nodes-in-locally-advanced-cervical-cancer-lead-to-more-aggressive-treatment-strategies
#9
Virginia Benito, Sonia Carballo, Patricia Silva, Miriam Esparza, Octavio Arencibia, Mario Federico, Miguel Andújar, Marta Mori, Norberto Medina, Amina Lubrano
OBJECTIVE: To evaluate risk factors in patients with locally advanced cervical cancer (LACC) undergoing pretherapeutic laparoscopic paraaortic lymphadenectomy (LPL), as well as the progression-free and overall survival rates specifically in the subgroup of patients with metastatic paraaortic lymph nodes (PLN). DESIGN: Retrospective study conducted on demographic data, pathological and surgical findings, complications and disease-status, recorded for LACC patients undergoing LPL during the period 2009-2015...
February 1, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28133240/-a-case-of-primary-peritoneal-cancer-successfully-treated-with-debulking-surgery-and-postoperative-chemotherapy
#10
Koki Maeda, Masami Tabata, Taiki Moriyama, Tatsuya Sakamoto, Yu Fujimura, Ichiro Ohsawa, Kenji Kato, Makoto Iwata, Takayuki Sanda
A 52-year-old woman with abdominal pain and a feeling of incomplete evacuation visited a local clinic. Enlargement of the right ovary was detected, and the patient was referred to the gynecological department of our hospital. CT and MRI revealed a round-shaped mass, 8 cm in diameter, with cystic and solid components in the Douglas pouch. The patient underwent a laparotomy under the diagnosis of ovarian cancer. Intraoperatively, both the ovaries appeared normal and the tumor strongly adhered to the rectum and uterus...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133142/-lynch-syndrome-caused-by-germline-alteration-of-mlh1-in-a-young-patient-who-developed-colon-and-endometrial-cancer-a-case-report
#11
Azusa Yamamoto, Okihide Suzuki, Noriyasu Chika, Tetsuya Ito, Yusuke Tajima, Kensuke Kumamoto, Hidetaka Eguchi, Youichi Kumagai, Keiichiro Ishibashi, Erito Mochiki, Yasushi Okazaki, Hideyuki Ishida
A 39-year-old woman underwent right colectomy for type-3 transverse colon cancer, which was histologically identified as well-differentiated stage II A adenocarcinoma with a mucinous component and tumor-infiltrating lymphocytes. The patient was suspected of having Lynch syndrome(LS)since she fulfilled 2 of the revised Bethesda criteria, even though there was no family history of LS. Twelve months after colectomy, abdominal CT revealed thickening of the uterine endometrium. Histopathological examination of biopsy specimens revealed well-differentiated endometrioid carcinoma...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28129244/aberrant-microrna-expression-in-patients-with-endometrial-cancer
#12
Martina Montagnana, Marco Benati, Elisa Danese, Silvia Giudici, Melissa Perfranceschi, Orazio Ruzzenenete, Gian Luca Salvagno, Antonella Bassi, Matteo Gelati, Elisa Paviati, Gian Cesare Guidi, Massimo Franchi, Giuseppe Lippi
OBJECTIVE: Current evidence suggests that no single serum biomarker displays satisfactory diagnostic performance in patients with endometrial carcinoma (EC), the most frequent gynecological cancer in developed countries. However, aberrant tissue microRNA (miRNA) expression has been recently described in EC. Therefore, this study aimed to investigate the differential expression of 4 serum miRNAs and their association with CA125 (cancer antigen 125) and HE4 (human epididymis protein 4) in EC patients and in a control population...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28129237/improved-outcome-of-high-grade-early-1-stage-endometrioid-endometrial-carcinoma-with-adjuvant-chemotherapy-and-radiotherapy-comparison-of-2-treatment-strategies
#13
Eline Aem Reynaers, Leah Jutzi, Nicole P M Ezendam, Janice S Kwon, Johanna M A Pijnenborg
OBJECTIVE: Patients with high-grade endometrioid endometrial carcinoma have a high risk of recurrence, even in early stage. To determine the benefit of a more aggressive adjuvant treatment approach, different treatment strategies of 2 referral centers were compared. MATERIALS AND METHODS: Outcome of all patients with International Federation of Gynecology and Obstetrics IB and II high-grade endometrioid endometrial carcinoma treated between 2008 and 2012, at the Gynecological Oncology Center South (GOCS) were compared with patients treated at the British Columbia Cancer Agency (BCCA)...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28121939/multiple-preinvasive-and-invasive-hpv-related-lesions-of-the-anogenital-tract-in-a-female-patient-with-hiv-infection-a-case-report
#14
Nicolò Clemente, Lara Alessandrini, Emanuela Vaccher, Antonino De Paoli, Monica Buttignol, Vincenzo Canzonieri, Francesco Sopracordevole
RATIONALE: Patients with human immunodeficiency virus (HIV) infection have been shown to be at increased risk for high-risk human papillomavirus (HR-HPV) infection of the anogenital tract. Furthermore, in the last decades, the introduction of highly active antiretroviral therapy (HAART) has increased the longevity of these patients who now live long enough to develop HPV-related cancers; hence, the impact of HPV infection on HIV-positive patients is of increasing concern. PATIENT CONCERNS: We reported the case of an HIV-positive female patient on HAART with a good virological and immunological response and with a long history of HPV-related intraepithelial and invasive lesions of the anogenital tract...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28120596/adenoid-cystic-carcinoma-of-bartholin-s-gland-case-report
#15
Mazdak Momeni, Yelena Korotkaya, Gonzalo Carrasco, Monica Prasad-Hayes
Primary adenoid cystic carcinoma (ACC) of Bartholin's gland is a rare gynecologic malignancy. We report a case of locally advanced ACC of Bartholin's gland. A 62-year-old presented with left Bartholin's gland carcinoma and underwent left radical vulvectomy, left-sided inguinal-femoral lymph node dissection, posterior pelvic exenteration, and pedicle abdominal muscle flap. On her 3 months follow-up exam she was disease free.Pelvic exenteration for thetreatment of this rare disease in the vulva is a potential curative option...
December 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/28118613/prognostic-value-of-abnormally-expressed-lncrnas-in-ovarian-carcinoma-a-systematic-review-and-meta-analysis
#16
REVIEW
Ping Luo, Xue-Fang Liu, Ying-Chao Wang, Nan-Di Li, Shen-Jun Liao, Ming-Xia Yu, Chun-Zi Liang, Jian-Cheng Tu
Ovarian cancer (OC) is the most deadly gynecological cancer and it is urgently needed to find a new marker for the progress of OC. Many long noncoding RNAs (lncRNAs) have been reported to be aberrantly expressed in ovarian carcinoma, and may serve as prognostic markers. Therefore, we conducted this meta-analysis to gain a better understanding of the prognostic value of lncRNAs in patients with varian carcinoma. We systematically searched PubMed, EMBASE, and Web of Science. A total of 13 eligible studies, including 10 on clinicopathological features, 13 on prognosis were identified...
January 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28118260/effect-of-different-segmentation-algorithms-on-metabolic-tumor-volume-measured-on-18f-fdg-pet-ct-of-cervical-primary-squamous-cell-carcinoma
#17
Weina Xu, Shupeng Yu, Ying Ma, Changping Liu, Jun Xin
BACKGROUND AND PURPOSE: It is known that fluorine-18 fluorodeoxyglucose PET/computed tomography (CT) segmentation algorithms have an impact on the metabolic tumor volume (MTV). This leads to some uncertainties in PET/CT guidance of tumor radiotherapy. The aim of this study was to investigate the effect of segmentation algorithms on the PET/CT-based MTV and their correlations with the gross tumor volumes (GTVs) of cervical primary squamous cell carcinoma. MATERIALS AND METHODS: Fifty-five patients with International Federation of Gynecology and Obstetrics stage Ia∼IIb and histologically proven cervical squamous cell carcinoma were enrolled...
March 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28101917/imaging-in-gynecological-disease-clinical-and-ultrasound-features-of-invasive-and-non-invasive-malignant-serous-ovarian-tumors
#18
F Moro, C Baima Poma, G F Zannoni, A Vidal Urbinati, T Pasciuto, M Ludovisi, M C Moruzzi, S Carinelli, D Franchi, G Scambia, A C Testa
OBJECTIVES: To describe clinical and ultrasound features of different subclasses of malignant serous ovarian tumors according to the WHO 2014 classification. METHODS: Patients with a histological diagnosis of borderline (BOT), non-invasive and invasive low grade serous carcinomas (LGSC) and high grade serous carcinoma (HGSC), who had undergone preoperative ultrasound examination, were retrospectively identified from two ultrasound centers. The masses were described using the terms of the International Ovarian Tumor Analysis group...
January 19, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28099710/predictive-value-of-serum-he4-and-ca125-concentrations-for-lymphatic-metastasis-of-endometrial-cancer
#19
Yingmei Wang, Cha Han, Fei Teng, Zhaoyi Bai, Wenyan Tian, Fengxia Xue
OBJECTIVE: To evaluate the predictive value of serum HE4 and CA125 concentrations in the preoperative prediction of risk of lymph node metastasis in endometrial cancer. METHODS: A retrospective study was undertaken of data for patients with endometrial carcinoma treated surgically at a university hospital in China between August 2011 and December 2015. The preoperative serum levels of HE4 and CA125 were measured and analyzed by clinicopathologic characteristics...
January 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099523/the-role-of-liquid-based-cytology-and-ancillary-techniques-in-the-peritoneal-washing-analysis-our-institutional-experience
#20
Esther Rossi, Tommaso Bizzarro, Maurizio Martini, Adhemar Longatto-Filho, Fernando Schmitt, Anna Fagotti, Giovanni Scambia, Gian Franco Zannoni
BACKGROUND: The cytological analysis of peritoneal effusions serves as a diagnostic and prognostic aid for either primary or metastatic diseases. Among the different cytological preparations, liquid based cytology (LBC) represents a feasible and reliable method ensuring also the application of ancillary techniques (i.e immunocytochemistry-ICC and molecular testing). METHODS: We recorded 10348 LBC peritoneal effusions between January 2000 and December 2014. They were classified as non-diagnostic (ND), negative for malignancy-NM, atypical-suspicious for malignancy-SM and positive for malignancy-PM...
2017: PloS One
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