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https://www.readbyqxmd.com/read/29452110/exploring-the-impact-of-house-screening-intervention-on-entomological-indices-and-incidence-of-malaria-in-arba-minch-town-southwest-ethiopia-a-randomized-control-trial
#1
Solomon Kinde Getawen, Temesgen Ashine, Fekadu Massebo, Daniel Woldeyes, Bernt Lindtjørn
House is the major site for malaria infection where most human-vector contact takes place. Hence, improving housing might reduce the risk of malaria infection by limiting house entry of vectors. This study aimed to explore the impact of screening doors and windows with wire meshes on density and entomological inoculation rate (EIR) of malaria vector, and malaria incidence, and assess the acceptability, durability, and cost of the intervention. The susceptibility status of malaria vector was also assessed. A two-arm randomized trial was done in Arba Minch Town, southwest Ethiopia...
February 13, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29451983/reinforcing-mucus-barrier-properties-with-low-molar-mass-chitosans
#2
Sujit Kootala, Luimar Filho, Vaibhav Srivastava, Victoria Linderberg, Amani Moussa, Laurent David, Stéphane Trombotto, Thomas Crouzier
The mucus gel covers the wet epithelia that forms the inner lining of the body. It constitutes our first line of defense protecting the body from infections and other deleterious molecules. Failure of the mucus barrier can lead to the inflammation of the mucosa such as in inflammatory bowel diseases. Unfortunately, there are no effective strategies that reinforce the mucus barrier properties to recover or enhance its ability to protect the epithelium. Herein, we describe a mucus engineering approach that addresses this issue where we physically crosslink the mucus gel with low molar mass chitosan variants to reinforce its barrier functions...
February 16, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29451805/loss-and-formation-of-malodorous-volatile-sulfhydryl-compounds-during-wine-storage
#3
Gal Y Kreitman, Ryan J Elias, David W Jeffery, Gavin L Sacks
Volatile sulfur compounds (VSCs), particularly low molecular weight sulfhydryls like hydrogen sulfide (H 2 S) and methanethiol (MeSH), are often observed in wines with sulfurous off-aromas. Recent work has shown both H 2 S and MeSH can increase up to a few µM (> 40 µg/L) during anoxic storage, but the identity of the latent sources of these sulfhydryls is still disputed. This review critically evaluates the latent precursors and pathways likely to be responsible for the loss and formation of these sulfhydryls during wine storage based on the existing enology literature as well as studies from food chemistry, geochemistry, biochemistry, and synthetic chemistry...
February 16, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29451422/intraperitoneal-onlay-mesh-technique-for-spigelian-hernia-in-an-outpatient-and-short-stay-surgery-unit-whats-new-in-intraperitoneal-meshes
#4
María Carmen Fernández-Moreno, Elena Martí-Cuñat, Guillermo Pou, Joaquín Ortega
BACKGROUND: Spigelian hernia (SH) is a rare entity, but its surgical treatment is essential because of its high complication risk. Laparoscopic approaches have become the option in elective surgery because it has less morbidity and requires a shorter stay. Several laparoscopic techniques have been employed, but there is no gold standard technique for this kind of hernia. We report, in this study, our experience with intraperitoneal onlay mesh (IPOM) repair. MATERIALS AND METHODS: Fifteen patients underwent elective surgery for SH between 2008 and 2015 in a Short-Stay Surgical Unit...
February 16, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29451371/young-s-modulus-and-load-complexity-modeling-their-effects-on-proximal-femur-strain
#5
Adam D Sylvester, Patricia A Kramer
Finite element analysis (FEA) is a powerful tool for evaluating questions of functional morphology, but the application of FEA to extant or extinct creatures is a non-trivial task. Three categories of input data are needed to appropriately implement FEA: geometry, material properties, and boundary conditions. Geometric data are relatively easily obtained from imaging techniques, but often material properties and boundary conditions must be estimated. Here we conduct sensitivity analyses of the effect of the choice of Young's Modulus for elements representing trabecular bone and muscle loading complexity on the proximal femur using a finite element mesh of a modern human femur...
February 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29451331/sliding-free-transverse-rectus-abdominis-myocutaneous-flap-for-closure-of-a-massive-abdominal-wall-defect-a-case-report
#6
Annika Senghaas, Thomas Kremer, Volker J Schmidt, Leila Harhaus, Christoph Hirche, Ulrich Kneser, Amir K Bigdeli
Despite considerable advances in reconstructive surgery, massive abdominal wall defects continue to pose a significant surgical challenge. We report the case of a 72-year-old morbidly obese female patient with Clostridium septicum-related gas gangrene of the abdominal wall. After multidisciplinary treatment and multiple extensive debridements, a massive full-thickness defect (40 cm × 35 cm) of the right abdominal wall was present. The abdominal contents were covered with a resorbable mesh to prevent evisceration...
February 16, 2018: Microsurgery
https://www.readbyqxmd.com/read/29450674/risk-assessment-of-pesticides-in-estuaries-a-review-addressing-the-persistence-of-an-old-problem-in-complex-environments
#7
Nagore Cuevas, Marta Martins, Pedro M Costa
Estuaries, coastal lagoons and other transition ecosystems tend to become the ultimate reservoirs of pollutants transported by continental runoff, among which pesticides constitute the class of most concern. High amounts of dissolved and particulated organic matter greatly contribute to the accumulation of pesticides that eventually become trapped in sediments or find their way along food chains. Perhaps not so surprisingly, it is common to find elevated levels of pesticides in estuarine sediments decades after their embargo...
February 15, 2018: Ecotoxicology
https://www.readbyqxmd.com/read/29449586/seismic-waveform-simulation-for-models-with-fluctuating-interfaces
#8
Ying Rao, Yanghua Wang
The contrast of elastic properties across a subsurface interface imposes a dominant influence on the seismic wavefield, which includes transmitted and reflected waves from the interface. Therefore, for an accurate waveform simulation, it is necessary to have an accurate representation of the subsurface interfaces within the numerical model. Accordingly, body-fitted gridding is used to partition subsurface models so that the grids coincide well with both the irregular surface and fluctuating interfaces of the Earth...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449162/is-video-based-education-an-effective-method-in-surgical-education-a-systematic-review
#9
Akgul Ahmet, Kus Gamze, Mustafaoglu Rustem, Karaborklu Argut Sezen
OBJECTIVE: Visual signs draw more attention during the learning process. Video is one of the most effective tool including a lot of visual cues. This systematic review set out to explore the influence of video in surgical education. We reviewed the current evidence for the video-based surgical education methods, discuss the advantages and disadvantages on the teaching of technical and nontechnical surgical skills. METHODS: This systematic review was conducted according to the guidelines defined in the preferred reporting items for systematic reviews and meta-analyses statement...
February 12, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29448888/cross-linked-cholecyst-derived-extracellular-matrix-for-abdominal-wall-repair
#10
Jeffrey Chee Yean Chan, Krishna Burugapalli, Yi-Shiang Huang, Jack L Kelly, Abhay Pandit
Abdominal wall repair frequently utilizes either non-degradable or bio-degradable meshes, which are found to stimulate undesirable biological tissue responses or which possess suboptimal degradation rate. In this study, a biologic mesh prototype made from carbodiimide-cross-linked cholecyst-derived extracellular matrix (EDCxCEM) was compared with small intestinal submucosa (Surgisis®), cross-linked bovine pericardium (Peri-Guard®), and polypropylene (Prolene®) meshes in an in vivo rabbit model. The macroscopic appearance and stereological parameters of the meshes were evaluated...
February 16, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29448578/oxygen-and-acrylic-acid-plasma-treatment-on-titanium-mesh-for-improving-the-hydroxyapatite-formation
#11
Youngseung Park, Byung-Hoon Kim, Seon-Ju Lee, Hong-Ju Park, Hee-Kyun Oh, Myung-Sun Kim, Min-Suk Kook
Customized titanium (Ti) meshes were treated with O2 plasma and acrylic acid plasmapolymerization (PPAAc). The optimum conditions for PPAAc were as follows: 20 W, 15 mTorr, and 5 min. Hydroxyapatite formation increased in Ti meshes treated with O2 and PPAAc compared with that in untreated Ti meshes. Moreover, MC3T3-E1 cells exhibited improved cell spreading, attachment, proliferation in PPAAc treated Ti mesh than in untreated Ti mesh. This result revealed that O2 and PPAAc surface treatment on Ti mesh was potential tool for improving the bone formation on the Ti mesh clinically application...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448490/capillary-network-formation-from-dispersed-endothelial-cells-influence-of-cell-traction-cell-adhesion-and-extracellular-matrix-rigidity
#12
João R D Ramos, Rui Travasso, João Carvalho
The formation of a functional vascular network depends on biological, chemical, and physical processes being extremely well coordinated. Among them, the mechanical properties of the extracellular matrix and cell adhesion are fundamental to achieve a functional network of endothelial cells, able to fully cover a required domain. By the use of a Cellular Potts Model and Finite Element Method it is shown that there exists a range of values of endothelial traction forces, cell-cell adhesion, and matrix rigidities where the network can spontaneously be formed, and its properties are characterized...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29448453/electroneutral-models-for-dynamic-poisson-nernst-planck-systems
#13
Zilong Song, Xiulei Cao, Huaxiong Huang
The Poisson-Nernst-Planck (PNP) system is a standard model for describing ion transport. In many applications, e.g., ions in biological tissues, the presence of thin boundary layers poses both modeling and computational challenges. In this paper, we derive simplified electroneutral (EN) models where the thin boundary layers are replaced by effective boundary conditions. There are two major advantages of EN models. First, it is much cheaper to solve them numerically. Second, EN models are easier to deal with compared to the original PNP system; therefore, it would also be easier to derive macroscopic models for cellular structures using EN models...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29447988/escmid-study-group-for-infections-in-compromised-hosts-esgich-consensus-document-on-the-safety-of-targeted-and-biological-therapies-an-infectious-diseases-perspective-agents-targeting-lymphoid-cells-surface-antigens-i-cd19-cd20-and-cd52
#14
REVIEW
Małgorzata Mikulska, Simone Lanini, Carlota Gudiol, Lubos Drgona, Giuseppe Ippolito, Mario Fernández-Ruiz, Bernd Salzberger
BACKGROUND: The present review is part of the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies. AIMS: To review, from an Infectious Diseases perspective, the safety profile of agents targeting CD19, CD20 and CD52 and to suggest preventive recommendations. SOURCES: Computer-based MEDLINE searches with MeSH terms pertaining to each agent or therapeutic family...
February 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29447987/escmid-study-group-for-infections-in-compromised-hosts-esgich-consensus-document-on-the-safety-of-targeted-and-biological-therapies-an-infectious-diseases-perspective-soluble-immune-effector-molecules-ii-agents-targeting-interleukins-immunoglobulins-and-complement
#15
REVIEW
Kevin L Winthrop, Xavier Mariette, Jose T Silva, Esther Benamu, Leonard H Calabrese, Alexandre Dumusc, Josef S Smolen, José María Aguado, Mario Fernández-Ruiz
BACKGROUND: The present review is part of the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies. AIMS: To review, from an Infectious Diseases perspective, the safety profile of agents targeting interleukins, immunoglobulins and complement factors and to suggest preventive recommendations. SOURCES: Computer-based MEDLINE searches with MeSH terms pertaining to each agent or therapeutic family...
February 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29447856/laparoscopic-sacrohysteropexy-in-a-12-weeks-pregnant-woman
#16
Berna Haliloglu Peker, Erdin Ilter, Hakan Peker, Aygen Celik, Ali Gursoy, Onur Gunaldi
STUDY OBJECTIVE: To demonstrate laparoscopic sacrohysteropexy for a case of uterine prolapse in a 12 weeks and 3 days pregnant woman. To our knowledge, this is the first case of laparoscopic sacrohysteropexy performed at 12th weeks of gestation to be reported in literature. DESIGN: A step-by-step explanation of the surgical procedure (Canadian Task Force classification III) SETTING: Uterine prolapse is very rare condition manifesting in an estimated 10000 to 15000 pregnancies (1)...
February 12, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29447405/the-representation-of-vulnerable-populations-in-quality-improvement-studies
#17
Asaph Rolnitsky, Maksim Kirtsman, Hanna R Goldberg, Michael Dunn, Chaim M Bell
Purpose: A mapping review to quantify representation of vulnerable populations, who suffer from disparity and often inequitable healthcare, in quality improvement (QI) research. Data sources: Studies published in 2004-2014 inclusive from Medline, Embase and Cochrane databases for English language research with the terms 'quality improvement' or 'quality control' or 'QI' and 'plan-do-study-act' or 'PDSA' in the years 2004-2014 inclusively. Study selection: Published clinical research that was a QI-themed, as identified by its declared search terms, MESH terms, abstract or title...
February 13, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29446946/rapid-convergence-of-energy-and-free-energy-profiles-with-qm-size-in-qm-mm-simulations-of-proton-transfer-in-dna
#18
Susanta Das, Kwangho Nam, Dan T Major
In recent years, a number of quantum mechanical-molecular mechanical (QM/MM) enzyme studies have investigated the dependence of reaction energetics on the size of the QM region using energy and free energy calculations. Here, we revisit the question of QM region size dependence in QM/MM simulations within the context of energy and free energy calculations using a proton transfer in a DNA base pair as a test case. In the simulations, the QM region was treated with a dispersion-corrected AM1/d-PhoT Hamiltonian, which was developed to accurately describe phosphoryl and proton transfer reactions, in conjunction with an electrostatic embedding scheme using the particle-mesh Ewald summation method...
February 15, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29446490/a-3-dimensional-printed-patient-specific-guide-system-for-minimally-invasive-plate-osteosynthesis-of-a-comminuted-mid-diaphyseal-humeral-fracture-in-a-cat
#19
Bill Oxley
OBJECTIVE: To report the use of a 3-dimensional (3D)-printed patient-specific reduction guide system to facilitate minimally invasive plate osteosynthesis (MIPO) of a humeral fracture in a cat. STUDY DESIGN: Case report. ANIMALS: A 9-year-old male neutered domestic short hair cat weighing 4.4 kg. METHODS: A 9-year-old male domestic short hair cat was presented with a comminuted, mid-diaphyseal left humeral fracture. Computed tomographic data were processed to yield 3D mesh representations of both humeri and subsequently manipulated in computer-aided design software...
February 15, 2018: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29446438/three-dimensional-3d-geometric-morphometric-analysis-of-human-premolars-to-assess-sexual-dimorphism-and-biological-ancestry-in-australian-populations
#20
Robin Yong, Sarbin Ranjitkar, Dimitra Lekkas, Demetrios Halazonetis, Alistair Evans, Alan Brook, Grant Townsend
OBJECTIVES: This study aimed to investigate size and shape variation of human premolars between Indigenous Australians and Australians of European ancestry, and to assess whether sex and ancestry could be differentiated between these groups using 3D geometric morphometrics. MATERIALS AND METHODS: Seventy dental casts from each group, equally subdivided by sex, were scanned using a structured-light scanner. The 3D meshes of upper and lower premolars were processed using geometric morphometric methods...
February 15, 2018: American Journal of Physical Anthropology
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