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https://www.readbyqxmd.com/read/28805073/do-you-know-what-your-kids-are-drinking-evaluation-of-a-media-campaign-to-reduce-consumption-of-sugar-sweetened-beverages
#1
Amy Bleakley, Amy Jordan, Giridhar Mallya, Michael Hennessy, Jessica Taylor Piotrowski
OBJECTIVE: This study evaluates a citywide media campaign that targeted reducing sugar-sweetened beverage (SSB) consumption as a strategy for addressing obesity. DESIGN: Rolling cross-sectional survey data, collected before and during the media campaign, with 1367 parents to assess exposure to and effect of a televised public service advertisement (TV PSA) developed using a reasoned action approach. SETTING: Televised public service advertisement campaign created by the Philadelphia Department of Public Health and disseminated on cable television channels within the Philadelphia market...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28803500/book-review-the-evidence-based-practitioner-applying-research-to-meet-client-needs-brown-catana-2017-the-evidence-based-practitioner-applying-research-to-meet-client-needs-philadelphia-pa-fa-davis-233-pp-us-59-95-isbn-978-0-8036-4366-6
#2
https://www.readbyqxmd.com/read/28801082/-how-to-videos-improve-residents-performance-of-essential-perioperative-electronic-medical-records-and-clinical-tasks
#3
Veronica Zoghbi, Robert C Caskey, Kristoffel R Dumon, Jacqueline M Soegaard Ballester, Ari D Brooks, Jon B Morris, Daniel T Dempsey
OBJECTIVE: The ability to use electronic medical records (EMR) is an essential skill for surgical residents. However, frustration and anxiety surrounding EMR tasks may detract from clinical performance. We created a series of brief, 1-3 minutes "how to" videos demonstrating 7 key perioperative EMR tasks: booking OR cases, placing preprocedure orders, ordering negative-pressure wound dressing supplies, updating day-of-surgery history and physical notes, writing brief operative notes, discharging patients from the postanesthesia care unit, and checking vital signs...
August 8, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28798265/characteristics-of-tobacco-purchases-in-urban-corner-stores
#4
Hannah G Lawman, Jennifer Dolatshahi, Giridhar Mallya, Stephanie Vander Veur, Ryan Coffman, Cheryl Bettigole, Alexis Wojtanowski, Judith Wylie-Rosett, Gary D Foster
INTRODUCTION: To examine the prevalence and patterns of tobacco purchases at low-income, urban corner stores. METHODS: Data on tobacco products and other purchases were collected through direct observation of customers' purchases (n=6369) at 120 urban corner stores in Philadelphia, Pennsylvania, from April to September 2012. RESULTS: Overall 13% of corner store purchases included tobacco products. The majority (61%) of tobacco purchases did not include any other products, and 5...
August 10, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28797266/does-growing-up-with-a-physician-influence-the-ethics-of-medical-students-relationships-with-the-pharmaceutical-industry-the-cases-of-the-us-and-poland
#5
Marta Makowska
BACKGROUND: Medical schools have a major impact on future doctors' ethics and their attitudes towards cooperation with the pharmaceutical industry. From childhood, medical students who are related to a physician are exposed to the characteristics of a medical career and learn its professional ethics not only in school but also in the family setting. The present paper sought to answer the research question: 'How does growing up with a physician influence medical students' perceptions of conflicts of interest in their relationships with industry?' METHODS: An anonymous questionnaire was completed by 451 medical students from four Philadelphia medical schools and 554 medical students from Warsaw Medical University during 2013...
August 10, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28797017/how-do-social-capital-and-hiv-aids-outcomes-geographically-cluster-and-which-sociocontextual-mechanisms-predict-differences-across-clusters
#6
Yusuf Ransome, Lorraine T Dean, Natalie D Crawford, David S Metzger, Michael B Blank, Amy S Nunn
BACKGROUND: Place of residence has been associated with HIV transmission risks. Social capital, defined as features of social organization that improve efficiency of society by facilitating coordinated actions, often varies by neighborhood, and hypothesized to have protective effects on HIV care continuum outcomes. We examined whether the association between social capital and 2 HIV care continuum outcomes clustered geographically and whether sociocontextual mechanisms predict differences across clusters...
September 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28790105/value-of-cytogenetic-abnormalities-in-adults-with-ph-negative-b-cell-precursor-acute-lymphoblastic-leukemia
#7
Marina Lafage-Pochitaloff, Laurence Baranger, Mathilde Hunault, Wendy Cuccuini, Christine Lefebvre, Audrey Bidet, Isabelle Tigaud, Virginie Eclache, Eric Delabesse, Chrystèle Bilhou-Nabéra, Christine Terré, Elise Chapiro, Nathalie Gachard, Marie-Joelle Mozziconacci, Geneviève Ameye, Sarah Porter, Nathalie Grardel, Marie C Béné, Yves Chalandon, Carlos Graux, Françoise Huguet, Véronique Lhéritier, Norbert Ifrah, Hervé Dombret
Multiple cytogenetic subgroups have been described in adult Philadelphia chromosome (Ph)-negative B-cell precursor (BCP) acute lymphoblastic leukemia (ALL), often comprising small numbers of patients. In this study, we aimed to reassess the prognostic value of cytogenetic abnormalities in a large series of 617 adult patients with Ph-negative BCP-ALL (median age, 38 years), treated in the intensified GRAALL-2003/2005 trials. Combined data from karyotype, DNA index, FISH and/or PCR screening for relevant abnormalities were centrally reviewed and were informative in 542 cases (88%), allowing classification in ten exclusive primary cytogenetic subgroups and in secondary subgroups including complex and monosomal karyotypes...
August 8, 2017: Blood
https://www.readbyqxmd.com/read/28781219/a-randomized-controlled-study-of-art-observation-training-to-improve-medical-student-ophthalmology-skills
#8
Jaclyn Gurwin, Karen E Revere, Suzannah Niepold, Barbara Bassett, Rebecca Mitchell, Stephanie Davidson, Horace DeLisser, Gil Binenbaum
PURPOSE: Observation and description are critical to the practice of medicine, and to ophthalmology in particular. However, medical education does not provide explicit training in these areas, and medical students are often criticized for deficiencies in these skills. We sought to evaluate the effects of formal observation training in the visual arts on the general and ophthalmologic observational skills of medical students. DESIGN: Randomized, single-masked, controlled trial...
August 3, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28777678/early-initiation-of-substance-use-as-an-indicator-of-problematic-substance-use-among-young-men-who-have-sex-with-men-ymsm
#9
Aleksandar Kecojevic, Corey H Basch, Stephen E Lankenau
BACKGROUND AND OBJECTIVES: Much research has documented that young men who have sex with men (YMSM) are at higher risk for substance use-related problems. This study examined the age of substance use initiation and it's relationship to current substance use-related problems among substance-using YMSM. DESIGN AND METHODS: A cross-sectional survey of 191 YMSM (aged 18 to 29) with recent histories of prescription drug misuse was conducted in Philadelphia in 2012-13...
August 4, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28774355/funding-quality-pre-kindergarten-slots-with-philadelphia-s-new-sugary-drink-tax-simulating-effects-of-using-an-excise-tax-to-address-a-social-determinant-of-health
#10
Brent A Langellier, Félice Lê-Scherban, Jonathan Purtle
OBJECTIVE: Philadelphia passed a 1·5-cent-per-ounce sweetened beverage tax (SBT). Revenue will fund 10 000 quality pre-kindergarten slots for poor children. It is imperative to understand how revenue from SBT can be used to fund programmes to address education and other social determinants of health. The objective of the present study was to simulate quality pre-kindergarten attendance, educational achievement and sugar-sweetened beverage (SSB) consumption among Philadelphia children and adolescents under six intervention scenarios: (i) no intervention; (ii) 10 000 additional quality pre-kindergarten slots; (iii) a 1·5-cent-per-ounce SBT; (iv) expanded pre-kindergarten and 1·5-cent-per-ounce SBT; (v) a 3-cent-per-ounce SBT; and (vi) expanded pre-kindergarten and 3-cent-per-ounce SBT...
August 4, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28768252/amniotic-fluid-concentrations-of-glial-fibrillary-acidic-protein-do-not-correlate-with-prenatal-metrics-in-fetuses-with-myelomeningocele
#11
Aimee G Kim, Enrico Danzer, Julie S Moldenhauer, Nahla Khalek, Lauren E McClain, Lindsay N Waqar, Holly L Hedrick, Mark P Johnson, N Scott Adzick, William H Peranteau, Alan W Flake
INTRODUCTION: We investigated the correlation of amniotic fluid (AF) concentrations of glial fibrillary acidic protein (GFAP) with prenatal features of myelomeningocele (MMC) and neurodevelopmental outcome after fetal MMC (fMMC) surgery. MATERIALS AND METHODS: AF was collected during fMMC surgery between December 2012 and November 2015. AF-GFAP concentration was determined by ELISA. Retrospective chart review identified the characteristics of the defect. Data regarding delivery and 1-year neurodevelopmental outcome was collected from The Children's Hospital of Philadelphia fMMC Registry...
July 29, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28766314/sex-differences-in-contraception-non-use-among-urban-adolescents-risk-factors-for-unintended-pregnancy
#12
Allison R Casola, Deborah B Nelson, Freda Patterson
BACKGROUND: Contraception non-use among sexually active adolescents is a major cause of unintended pregnancy (UP). METHODS: In this cross-sectional study we sought to identify overall and sex-specific correlates of contraception non-use using the 2015 Philadelphia Youth Risk Behavior Survey (YRBS) (N = 9540). Multivariate regression models were used to examine mental health, sexual activity, substance use, and violence indicators on reported contraception non-use among sexually active youth...
September 2017: Journal of School Health
https://www.readbyqxmd.com/read/28760302/developmental-therapeutics-in-myeloproliferative-neoplasms
#13
REVIEW
Prithviraj Bose, Srdan Verstovsek
The unprecedented success of the Janus kinase (JAK) 1/2 inhibitor ruxolitinib in myelofibrosis (MF) provided much-needed impetus for clinical drug development for the Philadelphia chromosome-negative myeloproliferative neoplasms. The survival benefit conferred by this agent, along with its marked efficacy with regard to spleen volume and symptom reduction, have made ruxolitinib the cornerstone of drug therapy in MF. However, there remain significant unmet needs in the treatment of patients with MF, and many novel classes of agents continue to be investigated in efforts to build on the progress made with ruxolitinib...
July 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28760298/minimal-residual-disease-assessment-and-risk-based-therapy-in-acute-lymphoblastic-leukemia
#14
REVIEW
Renato Bassan, Tamara Intermesoli, Annamaria Scattolin, Piera Viero, Elena Maino, Rosaria Sancetta, Francesca Carobolante, Francesca Gianni, Paola Stefanoni, Manuela Tosi, Orietta Spinelli, Alessandro Rambaldi
The study of minimal residual disease (MRD) in adult patients with acute lymphoblastic leukemia (ALL) allows a greater refinement of the individual risk classification and is the best support for risk-specific therapy with or without allogeneic hematopoietic cell transplantation (HCT). Using case-specific sensitive molecular probes or multiparametric flow cytometry on marrow samples obtained from the end of induction until midconsolidation, MRD assays can detect up to 1 leukemic cell of 10,000 total mononuclear cells (sensitivity, 0...
July 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28760293/philadelphia-positive-acute-lymphoblastic-leukemia-do-we-still-need-allogeneic-transplantation-argument-pro
#15
Veronika Bachanova
No abstract text is available yet for this article.
July 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28758365/evaluation-of-the-safety-of-iron-dextran-with-parenteral-nutrition-in-the-paediatric-inpatient-setting
#16
Dale Lee, Diane Barsky, Rachel Hughes, Julia Driggers, Nicole Poupard, Maria Mascarenhas
AIM: Practitioners often avoid administering iron dextran in parenteral nutrition (PN) for hospitalised children because of the concern for anaphylaxis. The primary aim of the present study was to determine the risk of anaphylaxis associated with exposure to PN containing iron dextran in the inpatient setting. METHODS: Charts were reviewed for all children admitted to The Children's Hospital of Philadelphia from January 1, 2011 to December 30, 2013 who received PN containing low molecular weight (LMW) iron dextran...
July 7, 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28758099/platelet-expression-of-pkcepsilon-oncoprotein-in-myelofibrosis-is-associated-with-disease-severity-and-thrombotic-risk
#17
Elena Masselli, Cecilia Carubbi, Giulia Pozzi, Silvia Martini, Franco Aversa, Daniela Galli, Giuliana Gobbi, Prisco Mirandola, Marco Vitale
BACKGROUND: Myelofibrosis (MF) is the most aggressive Philadelphia-negative chronic myeloproliferative neoplasm (MPN) with high morbidity and mortality due to thrombo-hemorrhagic complications and leukemic transformation. MF is characterized by profound alterations of megakaryocytopoiesis, with consequent abnormalities in platelet number and function. We recently showed that the overexpression of the oncoprotein PKCepsilon plays a key role in the aberrant differentiation of MF megakaryocyte clone and that its levels correlate with disease burden...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28753604/socs1-function-in-bcr-abl-mediated-myeloproliferative-disease-is-dependent-on-the-cytokine-environment
#18
Özlem Demirel, Olivier Balló, Pavankumar N G Reddy, Olesya Vakhrusheva, Jing Zhang, Astrid Eichler, Ramona Fernandes, Susanne Badura, Hubert Serve, Christian Brandts
Treatment with tyrosine kinase inhibitors is the standard of care for Philadelphia chromosome positive leukemias. However the eradication of leukemia initiating cells remains a challenge. Circumstantial evidence suggests that the cytokine microenvironment may play a role in BCR-ABL mediated leukemogenesis and in imatinib resistance. Gene expression analyses of BCR-ABL positive ALL long-term cultured cells revealed strong reduction of SOCS mRNA expression after imatinib treatment, thereby demonstrating a strong inhibition of cytokine signaling...
2017: PloS One
https://www.readbyqxmd.com/read/28752075/mir-155-effectively-induces-apoptosis-in-k562-philadelphia-positive-cell-line-through-upregulation-of-p27kip1
#19
Mahdi Edalati Fathabad, Morteza Karimipoor, Shaban Alizadeh, Asghar Abdoli, Amir Atashi, Mahtab Sayadi
Introduction: Chronic myelogenous leukemia (CML) is a myeloproliferative disorder caused by the Philadelphia chromosome translocation, at (9; 22), which results in BCR-ABL fusion tyrosine kinase oncoprotein. This fusion induces down-regulation of miR-155. Upregulation of miR-155 can influence cell fate via the effect on p27kip1 and apoptosis. The aim of this study was to induce apoptosis in K562 CML cell line by overexpression of miR-155. Methods: The K562 cell line was transfected with pLenti-III-pre mir155-GFP constructs through electroporation...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28749919/philadelphia-chromosome-like-acute-lymphoblastic-leukemia-progress-in-a-new-cancer-subtype
#20
Julia Wells, Nitin Jain, Marina Konopleva
Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a newly described, high-risk subtype of B-cell ALL. It is characterized by a gene expression profile similar to that of Ph-positive ALL; however, the BCR-ABL1 fusion is not present. The World Health Organization classification of myeloid neoplasms and acute leukemia recently was updated to include the Ph-like or BCR-ABL1-like ALL subtype of B-cell ALL as a provisional entity. Unlike Ph-positive ALL, which is characterized by the pathognomonic BCR-ABL1 fusion, Ph-like ALL is characterized by a multitude of different genetic rearrangements and mutations...
July 2017: Clinical Advances in Hematology & Oncology: H&O
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