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hyaluronan matrix

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https://www.readbyqxmd.com/read/28932127/an-in-vitro-model-of-renal-inflammation-after-ischemic-oxidative-stress-injury-nephroprotective-effects-of-a-hyaluronan-ester-with-butyric-acid-on-mesangial-cells
#1
Olga Baraldi, Francesca Bianchi, Viola Menghi, Andrea Angeletti, Anna Laura Croci Chiocchini, Maria Cappuccilli, Valeria Aiello, Giorgia Comai, Gaetano La Manna
BACKGROUND: Acute kidney injury, known as a major trigger for organ fibrosis and independent predictor of chronic kidney disease, is characterized by mesangial cell proliferation, inflammation and unbalance between biosynthesis and degradation of extracellular matrix. Therapeutic approaches targeting the inhibition of mesangial cell proliferation and matrix expansion may represent a promising opportunity for the treatment of kidney injury. An ester of hyaluronic acid and butyric acid (HB) has shown vasculogenic and regenerative properties in renal ischemic-damaged tissues, resulting in enhanced function recovery and minor degree of inflammation in vivo...
2017: Journal of Inflammation Research
https://www.readbyqxmd.com/read/28915283/clinical-evaluation-of-a-multi-modal-facial-serum-that-addresses-hyaluronic-acid-levels-in-skin
#2
Susana Raab, Margarita Yatskayer, Stephen Lynch, Megan Manco, Christian Oresajo
BACKGROUND: Hyaluronic acid (HA), the major glycosaminoglycan present in the human skin, is a key contributor to water retention and mechanical support in skin. The level, size, and functionality of cutaneous HA are known to diminish with age. Topical treatments designed to increase the HA content of skin have been met with limited success. The purpose of this study was to evaluate the tolerance and efficacy of a multi-modal facial serum containing HA, Proxylane (C-Xyloside), purple rice extract, and dipotassium glycyrrhizate in addressing HA levels in skin...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28871852/recombinant-human-hyaluronidase-facilitated-subcutaneous-immunoglobulin-infusion-in-primary-immunodeficiency-diseases
#3
Richard L Wasserman
Most primary immunodeficiency diseases (PIDDs) resulting in antibody deficiency require intravenous or subcutaneous immunoglobulin G (SCIG) replacement therapy. The flow and distribution of SCIG to the vasculature is impeded by the glycosaminoglycan hyaluronan in the extracellular matrix, which limits the infusion rate and volume per site, necessitating frequent infusions and multiple infusion sites. Hyaluronidase depolymerizes hyaluronan and is a spreading factor for injectable biologics. Recombinant human hyaluronidase (rHuPH20) increases SCIG absorption and dispersion...
September 5, 2017: Immunotherapy
https://www.readbyqxmd.com/read/28871437/free-radical-studies-of-components-of-the-extracellular-matrix-contributions-to-protection-of-biomolecules-and-biomaterials-from-sterilising-doses-of-ionising-radiation
#4
Barry J Parsons
The purpose of the current review is show how the principles and techniques of radiation chemistry have enabled the direct reactions of free radicals with biomolecules and biomaterials to be investigated at the molecular level. In particular, the review focusses on the free radical-induced fragmentation of glycosaminoglycans. Glycosaminoglycans are large linear polysaccharides consisting of repeating disaccharide units and are important components of the extracellular matrix (ECM) either in free form (hyaluronan) or as a component of proteoglycans...
September 4, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28863216/hyaluronan-rich-microenvironment-in-the-limbal-stem-cell-niche-regulates-limbal-stem-cell-differentiation
#5
Tarsis F Gesteira, Mingxia Sun, Yvette M Coulson-Thomas, Yu Yamaguchi, Lung-Kun Yeh, Vincent Hascall, Vivien J Coulson-Thomas
Purpose: Limbal epithelial stem cells (LSCs), located in the basal layer of the corneal epithelium in the corneal limbus, are vital for maintaining the corneal epithelium. LSCs have a high capacity of self-renewal with increased potential for error-free proliferation and poor differentiation. To date, limited research has focused on unveiling the composition of the limbal stem cell niche, and, more important, on the role the specific stem cell niche may have in LSC differentiation and function...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28860944/chronic-asthma-and-mesenchymal-stem-cells-hyaluronan-and-airway-remodeling
#6
Benjamin D Goldstein, Mark E Lauer, Arnold I Caplan, Tracey L Bonfield
BACKGROUND: Previous studies have demonstrated that ovalbumin sensitization promotes chronic asthma phenotype in murine asthma model. Human mesenchymal stem cells (hMSCs) are multipotent cells in vitro that have been shown to decrease inflammation and can reverse airway remodeling when infused into an in vivo chronic asthma model. However, the mechanism by which hMSCs reverse remodeling is still unclear. In this study, we hypothesized that hMSCs influence remodeling by decreasing extracellular matrix (ECM) deposition, more specifically by decreasing collagen I, collagen III, and hyaluronan synthesis...
2017: Journal of Inflammation
https://www.readbyqxmd.com/read/28858529/soft-substrates-containing-hyaluronan-mimic-the-effects-of-increased-stiffness-on-morphology-motility-and-proliferation-of-glioma-cells
#7
Katarzyna Pogoda, Robert Bucki, Fitzroy J Byfield, Katrina Cruz, Tongkeun Lee, Cezary Marcinkiewicz, Paul Janmey
Unlike many other cancer cells that grow in tumors characterized by an abnormally stiff collagen-enriched stroma, glioma cells proliferate and migrate in the much softer environment of the brain, which generally lacks the filamentous protein matrix characteristic of breast, liver, colorectal, and other types of cancer. Glial cell-derived tumors and the cells derived from them are highly heterogeneous and variable in their mechanical properties, their response to treatments, and their properties in vitro. Some glioma samples are stiffer than normal brain when measured ex vivo, but even those that are soft in vitro stiffen after deformation by pressure gradients that arise in the tumor environment in vivo...
August 31, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28842437/hypoxia-promotes-primitive-glycosaminoglycan-rich-extracellular-matrix-composition-in-developing-heart-valves
#8
Dorothy Amofa, Alexia Hulin, Yuji Nakada, Hesham A Sadek, Katherine E Yutzey
During postnatal heart valve development, glycosaminoglycan (GAG)-rich valve primordia transform into stratified valve leaflets composed of GAGs, fibrillar collagen, and elastin layers accompanied by decreased cell proliferation, as well as thinning and elongation. The neonatal period is characterized by the transition from a uterine environment to atmospheric oxygen, but the role of changing O2 levels in valve extracellular matrix (ECM) composition or morphogenesis are not well-characterized. Here, we show that tissue hypoxia decreases in mouse aortic valves in the days after birth, concomitant with ECM remodeling and cell cycle arrest of valve interstitial cells (VICs)...
August 25, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28839448/the-disease-modifying-effects-of-hyaluronan-in-the-osteoarthritic-disease-state
#9
REVIEW
Mathew A Nicholls, Anke Fierlinger, Faizan Niazi, Mohit Bhandari
Hyaluronic acid (HA) has been a treatment modality for patients with knee osteoarthritis (OA) for many years now. Since HA was first introduced for the treatment of painful knee OA, much has been elucidated regarding both the etiology of this disease and the mechanisms by which HA may mitigate joint pain and tissue destruction. The objectives of this article are to (1) describe the etiology and pathophysiology of OA including both what is known about the genetics and biochemistry, (2) describe the role of HA on disease progression, (3) detail the antinociceptive and anti-inflammatory actions of HA in OA, and (4) present evidence of disease-modifying effects of HA in the preservation and restoration of the extracellular matrix...
2017: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28837080/activation-of-matrix-hyaluronan-mediated-cd44-signaling-epigenetic-regulation-and-chemoresistance-in-head-and-neck-cancer-stem-cells
#10
REVIEW
Lilly Y W Bourguignon, Christine Earle, Marisa Shiina
Head and neck squamous cell carcinoma (HNSCC) is a solid tumor composed by a genotypically and phenotypically heterogeneous population of neoplastic cells types. High recurrence rate and regional metastases lead to major morbidity and mortality. Recently, many studies have focused on cellular and molecular mechanisms of tumor progression that can help to predict prognosis and to choose the best therapeutic approach for HNSCC patients. Hyaluronan (HA), an important glycosaminoglycan component of the extracellular matrix (ECM), and its major cell surface receptor, CD44, have been suggested to be important cellular mediators influencing tumor progression and treatment resistance in head and neck cancer...
August 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28828361/driving-pressure-and-mechanical-power-new-targets-for-vili-prevention
#11
REVIEW
Tommaso Tonetti, Francesco Vasques, Francesca Rapetti, Giorgia Maiolo, Francesca Collino, Federica Romitti, Luigi Camporota, Massimo Cressoni, Paolo Cadringher, Michael Quintel, Luciano Gattinoni
Several factors have been recognized as possible triggers of ventilator-induced lung injury (VILI). The first is pressure (thus the 'barotrauma'), then the volume (hence the 'volutrauma'), finally the cyclic opening-closing of the lung units ('atelectrauma'). Less attention has been paid to the respiratory rate and the flow, although both theoretical considerations and experimental evidence attribute them a significant role in the generation of VILI. The initial injury to the lung parenchyma is necessarily mechanical and it could manifest as an unphysiological distortion of the extracellular matrix and/or as micro-fractures in the hyaluronan, likely the most fragile polymer embedded in the matrix...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28828208/protein-microarray-analysis-identifies-key-cytokines-associated-with-malignant-middle-cerebral-artery-infarction
#12
Zhonghe Zhou, Jinghua Zhang, Xiaoqiu Li, Cheng Xia, Yaling Han, Huisheng Chen
INTRODUCTION: We aimed to explore potential cytokines involved in the malignant middle cerebral artery infarction (MMI) and elucidate their underlying regulatory mechanisms. METHODS: We first developed a cytokine profile by Quantibody(®) Human Cytokine Antibody Array7000 using serum samples from eight patients with MMI and eight patients with non-acute cerebral infarction (NACI). The differentially expressed cytokines were then identified in patients with MMI using two-tailed Student's t-test and Fisher's Exact Test compared with patients with NACI...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28821957/co-culture-of-chondrons-and-mesenchymal-stromal-cells-reduces-the-loss-of-collagen-vi-and-improves-extracellular-matrix-production
#13
H A Owida, T De Las Heras Ruiz, A Dhillon, Y Yang, N J Kuiper
Adult articular chondrocytes are surrounded by a pericellular matrix (PCM) to form a chondron. The PCM is rich in hyaluronan, proteoglycans, and collagen II, and it is the exclusive location of collagen VI in articular cartilage. Collagen VI anchors the chondrocyte to the PCM. It has been suggested that co-culture of chondrons with mesenchymal stromal cells (MSCs) might enhance extracellular matrix (ECM) production. This co-culture study investigates whether MSCs help to preserve the PCM and increase ECM production...
August 19, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28819182/impact-of-extracellular-matrix-on-engraftment-and-maturation-of-pluripotent-stem-cell-derived-cardiomyocytes-in-a-rat-myocardial-infarct-model
#14
Tatsuki Ogasawara, Satomi Okano, Hajime Ichimura, Shin Kadota, Yuki Tanaka, Itsunari Minami, Motonari Uesugi, Yuko Wada, Naoto Saito, Kenji Okada, Koichiro Kuwahara, Yuji Shiba
Pluripotent stem cell-derived cardiomyocytes show great promise in regenerating the heart after myocardial infarction; however, several uncertainties exist that must be addressed before clinical trials. One practical issue is graft survival following transplantation. Although a pro-survival cocktail with Matrigel has been shown to enhance graft survival, the use of Matrigel may not be clinically feasible. The purpose of this study was to test whether a hyaluronan-based hydrogel, HyStem, could be a substitute for Matrigel...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28815777/a-deficiency-of-the-link-protein-bral2-affects-the-size-of-the-extracellular-space-in-the-thalamus-of-aged-mice
#15
Michal Cicanic, Midori Edamatsu, Yoko Bekku, Ivan Vorisek, Toshitaka Oohashi, Lydia Vargova
Bral2 is a link protein stabilizing the binding between lecticans and hyaluronan in perineuronal nets and axonal coats (ACs) in specific brain regions. Using the real-time iontophoretic method and diffusion-weighted magnetic resonance, we determined the extracellular space (ECS) volume fraction (α), tortuosity (λ), and apparent diffusion coefficient of water (ADCW ) in the thalamic ventral posteromedial nucleus (VPM) and sensorimotor cortex of young adult (3-6 months) and aged (14-20 months) Bral2-deficient (Bral2(-/-) ) mice and age-matched wild-type (wt) controls...
August 16, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28810554/beneficial-effects-of-dried-pomegranate-juice-concentrated-powder-on-ultraviolet-b-induced-skin-photoaging-in-hairless-mice
#16
Su-Jin Kang, Beom-Rak Choi, Seung-Hee Kim, Hae-Yeon Yi, Hye-Rim Park, Chang-Hyun Song, Sae-Kwang Ku, Young-Joon Lee
The present study investigated the anti-aging effects of pomegranate juice concentrated powder (PCP) in hairless mice following 15 weeks of UVB irradiation (three times a week; 0.18 J/cm(2)). Skin moisturizing effects were evaluated through skin water, collagen type I and hyaluronan contents, as well as collagen type I and hyaluronan synthesis-related transcript levels. Wrinkle formation and edema scores (skin weights) were also assessed, along with skin matrix metalloproteinase (MMP)-1, MMP-9 and MMP-13 transcript levels...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28806513/intraperitoneal-delivery-of-cisplatin-via-a-hyaluronan-based-nanogel-in-situ-cross-linkable-hydrogel-hybrid-system-for-peritoneal-dissemination-of-gastric-cancer
#17
Seiichi Ohta, Shota Hiramoto, Yuki Amano, Shigenobu Emoto, Hironori Yamaguchi, Hironori Ishigami, Joji Kitayama, Taichi Ito
Intraperitoneal administration of chemotherapeutics is expected for the treatment of peritoneally disseminated gastric cancer because of poor migration of the drugs from the systemic circulation to the peritoneal cavity. In this study, for intraperitoneal delivery of cisplatin (CDDP), we developed a hyaluronan (HA)-based hybrid system in which CDDP-loaded HA nanogels were either physically encapsulated in or chemically conjugated to injectable HA hydrogels. Physical encapsulation enabled sustained release of HA nanogels from the HA hydrogel matrix for over a week...
August 24, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28803264/hyaluronan-in-the-experimental-injury-of-the-cartilage-biochemical-action-and-protective-effects
#18
REVIEW
Angela Avenoso, Angela D'Ascola, Michele Scuruchi, Giuseppe Mandraffino, Alberto Calatroni, Antonino Saitta, Salvatore Campo, Giuseppe M Campo
INTRODUCTION: Our knowledge of extracellular matrix (ECM) structure and function has increased enormously over the last decade or so. There is evidence demonstrating that ECM provides signals affecting cell adhesion, shape, migration, proliferation, survival, and differentiation. ECM presents many domains that become active after proteolytic cleavage. These active ECM fragments are called matrikines which play different roles; in particular, they may act as potent inflammatory mediators during cartilage injury...
August 12, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28734086/the-role-of-serum-hyaluronic-acid-determination-in-the-diagnosis-of-liver-fibrosis
#19
Monika Gudowska, Bogdan Cylwik, Lech Chrostek
The common pathway leading to liver fibrosis and cirrhosis is growing deposition of extracellular matrix (ECM). It results from molecular and histological rearrangement of collagens, glycoproteins and hyaluronans. Hyaluronic acid is a chief component of the extracellular matrix of connective tissues and plays the main structural role in the formation of ECM. The most important organ involved in the synthesis of hyaluronic acid is the liver. In this paper the meaning of hyaluronic acid in the diagnostics of liver diseases is discussed...
2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28730511/intermediate-molecular-mass-hyaluronan-and-cd44-receptor-interactions-enhance-neutrophil-phagocytosis-and-il-8-production-via-p38-and-erk1-2-mapk-signalling-pathways
#20
Cheng-Hsun Lu, Chia-Huei Lin, Ko-Jen Li, Chieh-Yu Shen, Cheng-Han Wu, Yu-Min Kuo, Ting-Syuan Lin, Chia-Li Yu, Song-Chou Hsieh
CD44 is a common leukocyte adhesion molecule expressed on the surface of various cells. Hyaluronan (HA), the natural ligand of CD44, is a simple repeated disaccharide with variable molecular mass that is widely distributed on cell surfaces and the connective tissue matrix. The binding of small molecular mass HA (SMM-HA, MW < 80 kDa) to CD44 on immune-related cells elicits cell proliferation, differentiation, and cytokine production. However, the effects and molecular basis of intermediate molecular mass HA (IMM-HA, MW ≈ 500 kDa)-CD44 interactions on polymorphonuclear neutrophil (PMN) functions have not been elucidated...
July 20, 2017: Inflammation
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