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https://www.readbyqxmd.com/read/29219062/assesment-of-irisin-adiponectin-and-leptin-levels-in-patients-with-schizophrenia
#1
Gamze Erzin, Canan Topcuoglu, Vahap Ozan Kotan, Senol Bayram, Kostas Fountulakis
BACKGROUND: The patients with schizophrenia are at increased risk for problems regarding metabolic parameters due to their lifestyle and antipsychotic treatment. OBJECTIVE: In this study, we aimed to evaluate the levels of adiponectin, leptin, irisin in patients with schizophrenia who were nondiabetic, nonobese and under antipsychotic treatment. METHOD: 5 ml sample of venous blood was collected from each participant. Blood cells were separated from the serum...
December 7, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29199640/effects-of-humidity-co-sub-2-sub-and-o-sub-2-sub-on-real-time-quantitation-of-breath-biomarkers-by-means-of-ptr-tof-ms
#2
Phillip Trefz, Jochen Schubert, Wolfram Miekisch
Proton-transfer-reaction-time-of-flight-mass-spectrometry (PTR-ToF-MS) represents an attractive tool for real-time analysis of VOC profiles in human breath. Quantification of breath VOCs by means of direct MS may be affected by the matrix as human breath does not only contains several hundred VOCs in the ppbV-pptV level but is water saturated and contains percentage levels of CO2. Investigation of breath biomarkers in clinical studies requires quantitative and comparable results. We, therefore, assesed systematically the effect of humidity, CO2 and O2 onto the results of PTR-MS analysis...
December 4, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29185863/comparison-of-the-diastereoisomeric-excess-of-uridine-inosine-and-adenosine-cyanohydrins-determined-by-hplc-dad-and-1h-nmr
#3
Rubria Marlen Martínez-Casares, Herminia Inés Pérez Méndez, Norberto Manjarrez Alvarez, Aida Solís Oba, Liliana Hernández Vázquez, Alberto López-Luna
The separation of the diastereoisomers of the nucleoside derivatives of uridine, inosine and adenosine was performed by HPLC using chiral and no chiral columns, it was observed with the no chiral columns the resolution was good enough to determine diastereoisomeric excess. These methods were compared with 1H NMR, and no significant differences were observed between the three techniques. Diastereoisomeric uridine (3a), inosine (3b) and adenosine (4c) cyanohydrins were resolved by 1H nuclear magnetic resonance (1H NMR), chiral normal phase-high-performance liquid chromatography-diode array detector (NP-HPLC-DAD) and reversed phase (RP-HPLC-DAD); these methods allowed the assesment of the percent diastereoisomeric excess (% de) of the nucleosidic cyanohydrins of 3a (4, 6 and 4), 3b (10, 8 and 6) and 4c (4, 4 and 4)...
November 29, 2017: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/29153369/retrospective-comparison-of-three-dimensional-imaging-sequences-in-the-visualization-of-posterior-fossa-cranial-nerves
#4
Suna Ors, Ercan Inci, Rustu Turkay, Atilla Kokurcan, Elif Hocaoglu
PURPOSE: To compare efficancy of three-dimentional SPACE (sampling perfection with application-optimized contrasts using different flip-angle evolutions) and CISS (constructive interference in steady state) sequences in the imaging of the cisternal segments of cranial nerves V-XII. METHODS: Temporal MRI scans from 50 patients (F:M ratio, 27:23; mean age, 44.5±15.9 years) admitted to our hospital with vertigo, tinnitus, and hearing loss were retrospectively analyzed...
December 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29149679/innovative-urban-forestry-governance-in-melbourne-investigating-green-placemaking-as-a-nature-based-solution
#5
Natalie Marie Gulsrud, Kelly Hertzog, Ian Shears
A nature-based approach to climate resilience aims to challenge and re-frame conventional environmental management methods by refocusing solutions from technological strategies to socio-ecological principles such as human well-being and community-based governance models, thereby improving and legitimizing the delivery of ecosystem services (ES). There are, however, many challenges to applying a socio-ecological agenda to urban climate resilience and thereby re-framing ES delivery as community and people focused, a knowledge gap extensively outlined in the environmental governance literature...
November 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/29120410/molecular-analysis-of-axonal-intrinsic-and-glial-associated-co-regulation-of-axon-degeneration
#6
Alejandra Catenaccio, Maica Llavero Hurtado, Paula Diaz, Douglas J Lamont, Thomas M Wishart, Felipe A Court
Wallerian degeneration is an active program tightly associated with axonal degeneration, required for axonal regeneration and functional recovery after nerve damage. Here we provide a functional molecular foundation for our undertstanding of the complex non-cell autonomous role of glial cells in the regulation of axonal degeneration. To shed light on the complexity of the molecular machinery governing axonal degeneration we employ a multi-model, unbiased, in vivo approach combining morphological assesment and quantitative proteomics with in silico-based higher order functional clustering to genetically uncouple the intrinsic and extrinsic processes governing Wallerian degeneration...
November 9, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29031037/-evaluation-of-anti-cancer-therapies-with-reimbursement-limited-to-comprehensive-cancer-centres-using-the-european-society-for-medical-oncology-magnitude-of-clinical-benefit-scale
#7
T Büchler, B Melichar, D Vrána, R Lemstrová, J Fínek, L Dušek, K Petráková, J Prausová
BACKGROUND: The costs of oncology treatments are increasing, due to the rising prevalence of malignant diseases and the introduction of expensive novel anti-cancer agents. The new European Society for Clinical Oncology (ESMO) has recently developed a new parametric system to evaluate the clinical benefit of drugs. The Magnitude of Clinical Benefit Scale (ESMO-MCBS) compares the contribution of a novel drug based on overall and progression-free survival and quality of life with those of current treatment options...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28959626/safety-assesment-of-bacillus-clausii-ubbc07-a-spore-forming-probiotic
#8
Suvarna G Lakshmi, N Jayanthi, M Saravanan, M Sudha Ratna
Probiotics are vital bacteria that colonize the intestine and modify its microflora with benefits for the host. Very few members of the Bacillus group are recognized as safe for use and hence only a few strains are available as commercial preparations for application in humans and animals. Acute and subacute studies in rats were conducted to establish safety of Bacillus clausii (B. clausii) UBBC07. In the acute toxicity study, the oral LD50 for B. clausii UBBC07 was found to be >5000 mg/kg (630 billion cfu/kg) body weight...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28959106/assesment-of-right-ventricle-function-with-speckle-tracking-echocardiography-after-the-percutaneous-closure-of-atrial-septal-defect
#9
Onder Ozturk, Unal Ozturk, Mehmet Zilkif Karahan
BACKGROUND: Transthoracic echocardiography is used for assessment of right ventricular (RV) function. Speckle tracking echocardiography (STE) is a new tool to assess myocardial function. The aim of this study was to evaluate RV function using STE in patients with atrial septal defect (ASD) before and the first month after percutaneous closure. METHODS: We prospectively examined 32 consecutive patients (9 male, 23 female) who underwent percutaneous transcatheter closure (PTC) of secundum ASD from June 2013 to December 2015...
September 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28937271/assessment-of-radiation-induced-secondary-cancer-risk-in-the-brazilian-population-from-left-sided-breast-3d-crt-using-mcnpx
#10
Bruno Melo Mendes, Bruno Machado Trindade, Telma Cristina Ferreira Fonseca, Tarcisio Passos Ribeiro de Campos
OBJECTIVE: The aim of this work was to simulate a 6MV conventional breast 3D conformational radiation therapy (3D-CRT) with physical wedges (50 Gy/25#) in the left breast, calculate the mean absorbed dose in the body organs using robust models and computational tools and estimate the secondary cancer-incidence risk to the Brazilian population. METHODS: The VW female phantom was used in the simulations. Planning target volume (PTV) was defined in the left breast...
October 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28877274/the-effect-of-silver-nanoparticles-on-composite-shear-bond-strength-to-dentin-with-different-adhesion-protocols
#11
Koohpeima Fatemeh, Mokhtari Mohammad Javad, Khalafi Samaneh
Objective: The purpose of this study was to investigate the effect of silver nanoparticles on composite shear bond strength using one etch and rinse and one self-etch adhesive systems. Material and Methods: Silver nanoparticles were prepared. Transmission electron microscope and X-ray diffraction were used to characterize the structure of the particles. Nanoparticles were applied on exposed dentin and then different adhesives and composites were applied. All samples were tested by universal testing machine and shear bond strength was assesed...
July 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28840058/p2x7-receptor-and-apoe-polymorphisms-and-survival-from-heart-failure-a-prospective-study-in-frail-patients-in-a-geriatric-unit
#12
Giuseppe Pasqualetti, Marta Seghieri, Eleonora Santini, Chiara Rossi, Edoardo Vitolo, Livia Giannini, Maria Giovanna Malatesta, Valeria Calsolaro, Fabio Monzani, Anna Solini
Heart failure (HF) is one of the most frequent cause of hospitalization in elderly and often coexists with concurrent geriatric syndromes, like cognitive disturbances; various pathophysiological mechanisms are shared by HF and cognitive decline, notably a substrate of low-grade inflammation. We investigated whether SNPs in the purinergic receptor (P2X7R) and apolipoprotein (APO) E genes, both involved in a series of inflammatory responses, are associated to HF or cognitive impairment and are able to predict post-discharge mortality in the elderly...
July 2017: Aging and Disease
https://www.readbyqxmd.com/read/28834407/psychometric-testing-of-integrare-an-instrument-for-the-assesment-of-pressure-ulcer-risk-in-inpatients
#13
Ana María Porcel-Gálvez, Rocío Romero-Castillo, Elena Fernández-García, Sergio Barrientos-Trigo
PURPOSE: The aim of this study is to evaluate the psychometric properties of INTEGRARE, an instrument based on Nursing Outcome Classification. METHOD: A multicenter, cross-sectional, methodological design was used. FINDINGS: The study included 3,835 patients. Internal consistency α = 0.86. Confirmatory factor analysis demonstrated the unidimensionality of the scale, indicating a good model fit (CMIN/DF = 4; GFI, CFI, NFI, IFI = 0.999; RMSEA = 0...
August 21, 2017: International Journal of Nursing Knowledge
https://www.readbyqxmd.com/read/28832086/assesment-of-the-orb%C3%A4-t-morphometry-on-west-anatol%C3%A4-an-dry-skulls
#14
Nilufer Goksin Yonguc, Nuket Gocmen-Mas, Funda Aksu, Mete Edizer, Sahika Pinar Akyer, Selim Hamit Karabekir
The orbit is very frequently damaged by traumas which results in not only with bone deficits, but also with functional deformities if reconstruction is not appropriate. Anatomical exposure of the bony orbit is of importance for both anatomists and surgeons who perform operation on this area. The current study evaluated the group of morphometrical parameters on 74 adult West Anatolian dry skulls and stereological surface area on the dry skull orbits while describing the clinical importance. Surface area on the orbital base of the skulls were also evaluated using stereological method, bilaterally...
August 23, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28727158/hplc-fingerprinting-approach-for-raw-material-assessment-and-unit-operation-tracking-for-ivig-production-from-cohn-i-ii-iii-fraction
#15
Sebastijan Peljhan, Tina Jakop, Dunja Šček, Vid Skvarča, Blaž Goričar, Romina Žabar, Nina Mencin
The plasma-derived IgG used either for diagnostic purpose or intravenous application (in form of IVIG) in various medical therapies is certainly gaining more and more attention on annual basis. Different manufacturing processes are used to isolate immunoglobulins from human plasma. However, a quest for alternative paths in IgG isolation not only requires development of the most efficient isolation process, but also a rapid and reliable analytics to track the purification. Fast and reliable fingerprint-based method for characterization of IgG prepared from Cohn I+II+III paste is presented in this paper...
July 20, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28724879/infectious-complications-in-patients-with-cardiac-implantable-electronic-devices-risk-factors-prevention-and-prognosis
#16
Anna Polewczyk, Wojciech Jacheć, Aneta M Polewczyk, Andrzej Tomasik, Marianna Janion, Andrzej Kutarski
INTRODUCTION Cardiac implantable electronic device (CIED) infections still constitute a significant challenge. The knowledge of risk factors for CIED infections is crucial for preventing infections and reducing mortality rates. OBJECTIVES The aim of this study was to assess the risk factors and long-term survival of patients with CIED infections. PATIENTS AND METHODS We analyzed the clinical data of 1837 patients (including 750 [40.9%] patients with CIED infections), who underwent transvenous lead extraction at a single institution between 2006 and 2015...
September 29, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28722512/in-silico-and-in-vitro-evaluation-of-two-novel-oximes-k378-and-k727-in-comparison-to-k-27-and-pralidoxime-against-paraoxon-ethyl-intoxication
#17
Maria Arshad, Muhammad Qaiser Fatmi, Kamil Musilek, Alamdar Hussain, Kamil Kuca, Georg Petroianu, Huba Kalasz, Syed Muhammad Nurulain
Organophosphate (OP) poisoning is a major global health issue; while compounds from this group have been used intensively over the last century, an effective antidote is still lacking. Oxime-type acetylcholinesterase (AChE) reactivators are used to reactivate the OP inhibited AChE. Pralidoxime is the only US Food and Drug Administration approved oxime for therapeutic use but its efficacy has been disappointing. Two novel oximes (K378 and K727) were investigated in silico and in vitro and compared with an experimental oxime (kamiloxime; K-27) and pralidoxime...
August 4, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28697953/3d-in-vitro-models-of-liver-fibrosis
#18
Leo A van Grunsven
Animal testing is still the most popular preclinical assessment model for liver fibrosis. To develop efficient anti-fibrotic therapies, robust and representative in vitro models are urgently needed. The most widely used in vitro fibrosis model is the culture-induced activation of primary rodent hepatic stellate cells. While these cultures have contributed greatly to the current understanding of hepatic stellate cell activation, they seem to be inadequate to cover the complexity of this regenerative response...
July 8, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28675853/histopathological-effects-responses-of-oxidative-stress-inflammation-apoptosis-biomarkers-and-alteration-of-gene-expressions-related-to-apoptosis-oxidative-stress-and-reproductive-system-in-chlorpyrifos-exposed-common-carp-cyprinus-carpio-l
#19
Serdar Altun, Selçuk Özdemir, Harun Arslan
In this study, we aimed to identify the toxic effects of chlorpyrifos exposure on the tissues of common carp. For this purpose, we evaluated histopathological changes in the brain, gills, liver, kidney, testis, and ovaries after 21 days of chlorpyrifos exposure. Activation of 8-OHdG, cleaved caspase-3, and iNOS were assesed by immunofluorescence assay in chlorpyrifos-exposed brain and liver tissue. Additionally, we measured the expression levels of caspase-3, caspase-8, iNOS, MT1, CYP1A, and CYP3A genes in chlorpyrifos-exposed brain tissue, as well as the expression levels of FSH and LH genes in chlorpyrifos-exposed ovaries, using qRT-PCR...
November 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28641568/an-expanding-role-of-biomarkers-in-pulmonary-arterial-hypertension
#20
Mustafa Yildiz, Alparslan Sahin, Michael Behnes, İbrahim Akin
BACKGROUND: Pulmonary Arterial Hypertension (PAH) is a chronic disease which may cause or result from multiple cardiopulmonary disorders. The disease has complex pathophysiological mechanisms and involves many systematic, cellular and molecular changes. Therefore, it is crucial to find out underlying mechanisms and detect biomarkers to achieve early and proper diagnosis, evaluating disease severity, for follow-up and monitor response to treatment. Many biomarkers for PAH have been investigated but yet no such biomarker has been found specific and easily accessible to use for the patients...
2017: Current Pharmaceutical Biotechnology
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