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https://www.readbyqxmd.com/read/29651276/liposome-entrapment-of-bacteriophages-improves-wound-healing-in-a-diabetic-mouse-mrsa-infection
#1
Sanjay Chhibber, Jasjeet Kaur, Sandeep Kaur
Diabetic populations are more prone to developing wound infections which results in poor and delayed wound healing. Infection with drug resistant organisms further worsen the situation, driving searches for alternative treatment approaches such as phage therapy. Major drawback of phage therapy, however, is low phage persistence in situ , suggesting further refinement of the approach. In the present work we address this issue by employing liposomes as delivery vehicles. A liposome entrapped phage cocktail was evaluated for its ability to resolve a Staphylococcus aureus -induced diabetic excission wound infection...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29625941/antioxidant-capacity-and-polyphenolic-content-of-the-echinocystis-lobata-michx-torr-et-a-gray-flowers
#2
Irina Ielciu, Daniela Hanganu, Ramona Păltinean, Laurian Vlase, Michel Frédérich, Ana-Maria Gheldiu, Daniela Benedec, Gianina Crişan
Echinocystis lobata (Michx.) Torr. et A.Gray is a spontaneous species in the Romanian flora, lesser studied by scientific literature, but which has proved significant activities in traditional medicine. The present study is aimed to provide data on the polyphenolic compounds in the composition of the flowers of this species and to test their biological potential. Polyphenols were identified and quantified using an HPLC-MS method. Tested biological activities were the cytotoxic, anti-plasmodial and antioxidant ones...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29621764/right-ventricular-functions-in-pulmonary-thromboembolism
#3
Tarik Yildirim, Fatih Akın, Ibrahim Altun, Seda Yildirim, Ozcan Basaran, Mustafa Soylu
<br><br>this is a letter to editor We have read with great interest the paper entitled 'Subclinical Atherosclerosis in Patients with Prior Pulmonary Thromboembolism' Buyukterzi et al.1 is very important study. We have some suggestions about this trial. Firstly there are several echocardiographic parameters are available to determine right ventricular functions. Fractional area change (FAC), tricuspit annular plane systolic excursion (TAPSE), tissue Doppler derived right ventricular systolic excursion velocity S', strain and strain rate are the major determiner of right ventricular systolic functions...
April 5, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29561964/mid-term-results-of-surgical-treatment-of-atrial-fibrillation-in-valvular-heart-disease-assesed-by-speckle-tracking-echocardiography
#4
Natalia Lorenzo, Irene Mendez, Mikel Taibo, Gianfranco Martinis, Sara Badia, Guillermo Reyes, Rio Aguilar
BACKGROUND: Atrial fibrillation frequently affects patients with valvular heart disease. Ablation of atrial fibrillation during valvular surgery is an alternative for restoring sinus rhythm. OBJECTIVES: This study aimed to evaluate mid-term results of successful atrial fibrillation surgical ablation during valvular heart disease surgery, to explore left atrium post-ablation mechanics and to identify predictors of recurrence. METHODS: Fifty-three consecutive candidates were included...
March 19, 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29498800/syncope-as-a-subject-of-the-risk-assesment-of-pulmonary-thromboembolism-to-be-used-for-a-cross-sectional-study
#5
Songul Ozyurt, Savas Ozsu, Muge Erbay, Funda Oztuna, Aziz Gumus, Unal Sahin
INTRODUCTION: Syncope is infrequent in pulmonary thromboembolism (PTE) yet might be indicative of haemodynamic instability. The prognostic role of syncope in PTE has not been well documented. OBJECTIVES: In this study, the association between risk classification of the European Society of Cardiology and syncope was investigated in the normotensive PTE patients. METHODS: We retrospectively screened electronic medical records of patients who were admitted in two tertiary care hospital and diagnosis of PTE with computed tomography pulmonary angiography...
March 2, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29487397/contemporary-approach-to-predict-early-biochemical-recurrence-after-radical-prostatectomy-update-of-the-walz-nomogram
#6
Raisa S Pompe, Marco Bandini, Felix Preisser, Michele Marchioni, Emanuele Zaffuto, Zhe Tian, Georg Salomon, Thorsten Schlomm, Hartwig Huland, Markus Graefen, Derya Tilki, Shahrokh F Shariat, Pierre I Karakiewicz
BACKGROUND: Early biochemical recurrence (eBCR) after radical prostatectomy (RP) heralds poor oncological outcomes and may be prevented with adjuvant radiation (aRT). METHODS: We developed a contemporary eBCR nomogram in 13 797 RP patients from Hamburg (2005-2016) and externally validated it in 5952 RP patients from Vienna. Receiver operating characteristics-derived area under the curve (AUC), Heagerty's C-index, and decision curve analysis (DCA) were used to quantify model accuracy and to compare the current tool with the Walz nomogram, the online Memorial Sloan Kettering Cancer Center (MSKCC) nomogram and the post-surgical Cancer of the Prostate Risk Assesment (CAPRA-S)...
February 27, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29477793/improved-sulfide-mitigation-in-sewers-through-on-line-control-of-ferrous-salt-dosing
#7
Ramon Ganigué, Guangming Jiang, Yiqi Liu, Keshab Sharma, Yue-Cong Wang, José Gonzalez, Tung Nguyen, Zhiguo Yuan
Water utilities worldwide spend annually billions of dollars to control sulfide-induced corrosion in sewers. Iron salts chemically oxidize and/or precipitate dissolved sulfide in sewage and are especially used in medium- and large-size sewers. Iron salt dosing rates are defined ad hoc, ignoring variation in sewage flows and sulfide levels. This often results in iron overdosing or poor sulfide control. Online dosing control can adjust the chemical dosing rates to current (and future) state of the sewer system, allowing high-precision, stable and cost-effective sulfide control...
February 13, 2018: Water Research
https://www.readbyqxmd.com/read/29444169/monitoring-chest-compression-quality-during-cardiopulmonary-resuscitation-proof-of-concept-of-a-single-accelerometer-based-feedback-algorithm
#8
Digna María González-Otero, Jesus María Ruiz, Sofía Ruiz de Gauna, Jose Julio Gutiérrez, Mohamud Daya, James Knox Russell, Izaskun Azcarate, Mikel Leturiondo
BACKGROUND: The use of real-time feedback systems to guide rescuers during cardiopulmonary resuscitation (CPR) significantly contributes to improve adherence to published resuscitation guidelines. Recently, we designed a novel method for computing depth and rate of chest compressions relying solely on the spectral analysis of chest acceleration. That method was extensively tested in a simulated manikin scenario. The purpose of this study is to report the results of this method as tested in human out-of-hospital cardiac arrest (OHCA) cases...
2018: PloS One
https://www.readbyqxmd.com/read/29435616/the-response-of-lemna-minor-to-mixtures-of-pesticides-that-are-commonly-used-in-thailand
#9
Rungnapa Tagun, Alistair B A Boxall
In the field, aquatic organisms are exposed to multiple contaminants rather than to single compounds. It is therefore important to understand the toxic interactions of co-occurring substances in the environment. The aim of the study was to assess the effects of individual herbicides (atrazine, 2,4-D, alachlor and paraquat) that are commonly used in Thailand and their mixtures on Lemna minor. Plants were exposed to individual and binary mixtures for 7 days and the effects on plant growth rate were assesed based on frond area measurements...
February 13, 2018: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29428870/physiological-assesment-of-vestibular-function-and-toxicity-in-humans-and-animals
#10
Jordi Llorens, Angela Callejo, Erin A Greguske, Alberto F Maroto, Blanca Cutillas, Vanessa Martins-Lopes
Physiological methods that can be similarly recorded in humans and animals have a major role in sensory toxicology, as they provide a bridge between human sensory perception data and the molecular and cellular data obtained in animal studies. Vestibular toxicity research lags well behind other sensory systems in many aspects, including the availability of methods for functional assessment in animals that could be robustly translated to human significance. Here we review the methods available for the assessment of vestibular function in both humans and laboratory animals, with an emphasis on their similarity or divergence, to highlight their potential utility for the predictive assessment of vestibular toxicity...
February 8, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29416210/assesment-of-rhythm-disorders-in-classical-and-nonclassical-mitral-valve-prolapse
#11
Enisa Hodzic
Introduction: Mitral Valve Prolapse (MVP) is the most common cardiac valve pathology of to day. Aim of article was to identify the types and frequency of potentially malignant arrhythmia and atrial brillation in patients with MVP, to determine the differences in these arrhythmias between classical and non-classical MVP, to evaluate the correlation of potentially malignant arrhythmia and atrial fibrillation with MVP with possible clinical complications of arrhythmogenic sudden cardiac death and potential risk of thromboembolic vascular incident...
February 2018: Medical Archives
https://www.readbyqxmd.com/read/29414093/ultrasensitive-direct-impedimetric-immunosensor-for-detection-of-serum-her2
#12
Shikha Sharma, Julia Zapatero-Rodríguez, Rahul Saxena, Richard O'Kennedy, Sudha Srivastava
Assesment of human epidermal growth factor receptor 2 status is a key factor prompting definitive treatment decisions that help in reducing mortality rates associated with breast cancer. In this article, highly sensitive and low-cost impedimetric immunosensor using single-chain fragment variable antibody fragments was developed for quantitative detection of human epidermal growth factor receptor 2 from serum employing gold nanoparticle-modified disposable screen-printed carbon electrodes. The gold nanoparticles facilitate fast electron transfer and offer a biocompatible surface for immobilization of small antibody fragments in an oriented manner, resulting in improved antigen binding efficiency...
January 31, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29386154/assesment-of-predictor-variables-and-clinical-consequences-associated-with-surgical-site-infection-in-tertiary-care-setting-karachi-pakistan
#13
Anum Tariq, Huma Ali, Farya Zafar, Ali Akbar Sial, Kamran Hameed, Mehwish Rizvi, Rabia Bushra, Saima Salim, Zeb-Un Nisa, Ghazala R Naqvi, Saba Zubair
Among the well-known Health care-associated infections (HAIs), surgical site infections (SSIs) contribute to considerable high mortality and morbidity rate, substantial prolongation in hospitalization period and extra expenses in terms of treatment cost. This study was aimed to evaluate the predictive variables associated with surgical site infections, and their clinical consequences. This was a prospective, cross sectional study conducted in the surgical department of tertiary care setting in Karachi, Pakistan...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29374405/shortwave-infrared-raman-spectroscopic-classification-of-water-fractions-in-articular-cartilage-ex-vivo
#14
Mustafa Unal, Ozan Akkus
Water loss is an early onset indicator of osteoarthritis. Although Raman spectroscopy (RS) holds the potential for measurement of cartilage hydration, the knowledge of Raman OH-stretch bands of biological tissue is very limited. We assesed here the sensitivity of RS to identify and classify water types in the cartilage. Raman spectrum measurements over the high wavenumber range were employed to identify different water fractions in articular cartilage. Raman spectra were collected from wet and sequentially dehydrated cartilage along with pure collagen type II and chondroitin sulfate standards...
January 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29364458/nail-psoriasis-treated-with-pulsed-dye-laser
#15
Juliano Peruzzo, Gabriela Czarnobay Garbin, Gabriela Maldonado, Tania Ferreira Cestari
Nail changes are present in about 50% of psoriasis patients and tend to be refractory to conventional treatments. Pulsed dye laser has emerged as an alternative therapy. Our aim is to evaluate the efficacy of pulsed dye laser in nail psoriasis and the impact of treatment on quality of life. Fourteen patients were treated in monthly sessions for three months. The outcome assesment was made by the Nail Psoriasis Severity Index (NAPSI). The median improvement in the scores of the overall NAPSI, nail bed NAPSI, and nail matrix NAPSI were 44...
November 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29333039/pharmacognostic-assesment-of-the-endemic-and-vulnerable-medicinal-climber-cayratia-pedata-lam-gagnep-var-glabra-gamble-and-its-antibacterial-activity
#16
S Sharmila, K Kalaichelvi, S M Dhivya, P Premamalini, P Abirami, G Jayanthi
Objective: The objective of this study is to evaluate a meticulous pharmacognostic cram is to supplement constructive information with regard to its identification, characterization, and standardization of endemic and endangered medicinal climber Cayratia pedata var. glabra and also screening the antibacterial activity of this climber. Materials and Methods: The morphological characters of study plant, microscopic examination of leaf powder, anatomy of young stem, physicochemical analysis of plant powder, extractive values, phytochemical analysis, powder with different chemical reagents, fluorescence analysis of plant powder, and other World Health Organization (WHO) recommended for standardization were analyzed...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29329713/baseline-and-pre-operative-1-year-mortality-risk-factors-in-a-cohort-of-509-hip-fracture-patients-consecutively-admitted-to-a-co-managed-orthogeriatric-unit-fonda-cohort
#17
Rocío Menéndez-Colino, Teresa Alarcon, Pilar Gotor, Rocío Queipo, Raquel Ramírez-Martín, Angel Otero, Juan I González-Montalvo
INTRODUCTION: The aim of this study was to determine the patient characteristics that predict 1-year mortality after a hip fracture (HF). METHODS: All patients admitted consecutively with fragility HF during 1 year in a co-managed orthogeriatric unit of a university hospital (FONDA cohort) were assesed. Baseline and admission demographic, clinical, functional, analytical and body-composition variables were collected in the first 72 h after admission. A protocol designed to minimize the consequences of the HF was applied...
March 2018: Injury
https://www.readbyqxmd.com/read/29319139/the-role-of-99mtc-dtpa-retrobulbar-spect-in-staging-and-follow-up-of-graves-orbitopathy
#18
László Galuska, Sándor Barna, József Varga, Ildikó Garai, Endre V Nagy
The pathogenesis of Graves' orbitopathy (GO) is not completely understood. Coexistent hyperfunction of the thyroid gland is frequent; however, GO may also coexist with hypo- or euthyrodism. The course of GO is largely independent of thyroid function, although elevated serum TSH is known to negatively interfere with GO course. GO is severe in 10 % of the cases; sight threatening complications may also develop. A successful therapy of GO requires the assesment of both the severity and activity of orbital inflammation...
January 10, 2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29288881/a-novel-screening-method-to-identify-late-stage-dementia-patients-for-palliative-care-research-and-practice
#19
Natalie C Ernecoff, Kathryn L Wessell, Stacey Gabriel, Timothy S Carey, Laura C Hanson
CONTEXT: Investigators need novel methods for timely identification of patients with serious illness to test or implement new palliative care models. OBJECTIVES: The study's aim was to develop an electronic health record (EHR) phenotype to identify patients with late-stage dementia for a clinical trial of palliative care consultation. METHODS: We developed a computerized method to identify patients with dementia on hospital admission. Within a data warehouse derived from the hospital's EHR, we used search terms of age, admission date, and ICD-9 and ICD-10 diagnosis codes to create an EHR dementia phenotype, followed by brief medical record review to confirm late-stage dementia...
April 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29284941/a-comparative-evaluation-of-bifidobacteria-levels-in-early-childhood-caries-and-severe-early-childhood-caries
#20
Suraj Nair, V Suresh Kumar, Ramesh Krishnan, Pooja Rajan
Background: Bifidobacteria levels in saliva were found to be significantly correlated in adults with dental caries but less information available in the literature regarding its role in children. Aim: The aim is to compare the salivary levels of Bifidobacteria in children who are caries free with that of early childhood caries (ECC) and severe ECC (S-ECC). Materials and Methods: Saliva was collected using the tongue-loop method from a total of 60 children between the age group of 3-5 years and they were further divided into 3 groups...
November 2017: Journal of Pharmacy & Bioallied Sciences
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