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https://www.readbyqxmd.com/read/29031037/-evaluation-of-anti-cancer-therapies-with-reimbursement-limited-to-comprehensive-cancer-centres-using-the-european-society-for-medical-oncology-magnitude-of-clinical-benefit-scale
#1
T Büchler, B Melichar, D Vrána, R Lemstrová, J Fínek, L Dušek, K Petráková, J Prausová
BACKGROUND: The costs of oncology treatments are increasing, due to the rising prevalence of malignant diseases and the introduction of expensive novel anti-cancer agents. The new European Society for Clinical Oncology (ESMO) has recently developed a new parametric system to evaluate the clinical benefit of drugs. The Magnitude of Clinical Benefit Scale (ESMO-MCBS) compares the contribution of a novel drug based on overall and progression-free survival and quality of life with those of current treatment options...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28959626/safety-assesment-of-bacillus-clausii-ubbc07-a-spore-forming-probiotic
#2
Suvarna G Lakshmi, N Jayanthi, M Saravanan, M Sudha Ratna
Probiotics are vital bacteria that colonize the intestine and modify its microflora with benefits for the host. Very few members of the Bacillus group are recognized as safe for use and hence only a few strains are available as commercial preparations for application in humans and animals. Acute and subacute studies in rats were conducted to establish safety of Bacillus clausii (B. clausii) UBBC07. In the acute toxicity study, the oral LD50 for B. clausii UBBC07 was found to be >5000 mg/kg (630 billion cfu/kg) body weight...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28959106/assesment-of-right-ventricle-function-with-speckle-tracking-echocardiography-after-the-percutaneous-closure-of-atrial-septal-defect
#3
Onder Ozturk, Unal Ozturk, Mehmet Zilkif Karahan
BACKGROUND: Transthoracic echocardiography is used for assessment of right ventricular (RV) function. Speckle tracking echocardiography (STE) is a new tool to assess myocardial function. The aim of this study was to evaluate RV function using STE in patients with atrial septal defect (ASD) before and the first month after percutaneous closure. METHODS: We prospectively examined 32 consecutive patients (9 male, 23 female) who underwent percutaneous transcatheter closure (PTC) of secundum ASD from June 2013 to December 2015...
September 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28937271/assesment-of-radiation-induced-secondary-cancer-risk-in-the-brazilian-population-from-left-sided-breast-3d-crt-using-mcnpx
#4
Bruno Melo Mendes, Bruno Machado Trindade, Telma Cristina Ferreira Fonseca, Tarcisio Passos Ribeiro de Campos
OBJECTIVE: The aim of this work was to simulate a 6MV conventional breast 3D conformational radiotherapy (3D-CRT) with physical wedges (50Gy/25#) in the left breast, calculate the mean absorbed dose in the body organs using robust models and computational tools and estimate the secondary cancer-incidence risk to the Brazilian population. METHODS: The VW female phantom was used in the simulations. PTV was defined in the left breast. The 6MV parallel-opposed fields breast-RT protocol was simulated with MCNPx code...
September 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28877274/the-effect-of-silver-nanoparticles-on-composite-shear-bond-strength-to-dentin-with-different-adhesion-protocols
#5
Koohpeima Fatemeh, Mokhtari Mohammad Javad, Khalafi Samaneh
Objective: The purpose of this study was to investigate the effect of silver nanoparticles on composite shear bond strength using one etch and rinse and one self-etch adhesive systems. Material and Methods: Silver nanoparticles were prepared. Transmission electron microscope and X-ray diffraction were used to characterize the structure of the particles. Nanoparticles were applied on exposed dentin and then different adhesives and composites were applied. All samples were tested by universal testing machine and shear bond strength was assesed...
July 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28840058/p2x7-receptor-and-apoe-polymorphisms-and-survival-from-heart-failure-a-prospective-study-in-frail-patients-in-a-geriatric-unit
#6
Giuseppe Pasqualetti, Marta Seghieri, Eleonora Santini, Chiara Rossi, Edoardo Vitolo, Livia Giannini, Maria Giovanna Malatesta, Valeria Calsolaro, Fabio Monzani, Anna Solini
Heart failure (HF) is one of the most frequent cause of hospitalization in elderly and often coexists with concurrent geriatric syndromes, like cognitive disturbances; various pathophysiological mechanisms are shared by HF and cognitive decline, notably a substrate of low-grade inflammation. We investigated whether SNPs in the purinergic receptor (P2X7R) and apolipoprotein (APO) E genes, both involved in a series of inflammatory responses, are associated to HF or cognitive impairment and are able to predict post-discharge mortality in the elderly...
July 2017: Aging and Disease
https://www.readbyqxmd.com/read/28834407/psychometric-testing-of-integrare-an-instrument-for-the-assesment-of-pressure-ulcer-risk-in-inpatients
#7
Ana María Porcel-Gálvez, Rocío Romero-Castillo, Elena Fernández-García, Sergio Barrientos-Trigo
PURPOSE: The aim of this study is to evaluate the psychometric properties of INTEGRARE, an instrument based on Nursing Outcome Classification. METHOD: A multicenter, cross-sectional, methodological design was used. FINDINGS: The study included 3,835 patients. Internal consistency α = 0.86. Confirmatory factor analysis demonstrated the unidimensionality of the scale, indicating a good model fit (CMIN/DF = 4; GFI, CFI, NFI, IFI = 0.999; RMSEA = 0...
August 21, 2017: International Journal of Nursing Knowledge
https://www.readbyqxmd.com/read/28832086/assesment-of-the-orb%C3%A4-t-morphometry-on-west-anatol%C3%A4-an-dry-skulls
#8
Nilufer Goksin Yonguc, Nuket Gocmen-Mas, Funda Aksu, Mete Edizer, Sahika Pinar Akyer, Selim Hamit Karabekir
The orbit is very frequently damaged by traumas which results in not only with bone deficits, but also with functional deformities if reconstruction is not appropriate. Anatomical exposure of the bony orbit is of importance for both anatomists and surgeons who perform operation on this area. The current study evaluated the group of morphometrical parameters on 74 adult West Anatolian dry skulls and stereological surface area on the dry skull orbits while describing the clinical importance. Surface area on the orbital base of the skulls were also evaluated using stereological method, bilaterally...
August 23, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28727158/hplc-fingerprinting-approach-for-raw-material-assessment-and-unit-operation-tracking-for-ivig-production-from-cohn-i-ii-iii-fraction
#9
Sebastijan Peljhan, Tina Jakop, Dunja Šček, Vid Skvarča, Blaž Goričar, Romina Žabar, Nina Mencin
The plasma-derived IgG used either for diagnostic purpose or intravenous application (in form of IVIG) in various medical therapies is certainly gaining more and more attention on annual basis. Different manufacturing processes are used to isolate immunoglobulins from human plasma. However, a quest for alternative paths in IgG isolation not only requires development of the most efficient isolation process, but also a rapid and reliable analytics to track the purification. Fast and reliable fingerprint-based method for characterization of IgG prepared from Cohn I+II+III paste is presented in this paper...
July 20, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28724879/infectious-complications-in-patients-with-cardiac-implantable-electronic-devices-risk-factors-prevention-and-prognosis
#10
Anna Polewczyk, Wojciech Jacheć, Aneta M Polewczyk, Andrzej Tomasik, Marianna Janion, Andrzej Kutarski
INTRODUCTION Cardiac implantable electronic device (CIED) infections still constitute a significant challenge. The knowledge of risk factors for CIED infections is crucial for preventing infections and reducing mortality rates. OBJECTIVES The aim of this study was to assess the risk factors and long-term survival of patients with CIED infections. PATIENTS AND METHODS We analyzed the clinical data of 1837 patients (including 750 [40.9%] patients with CIED infections), who underwent transvenous lead extraction at a single institution between 2006 and 2015...
September 29, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28722512/in-silico-and-in-vitro-evaluation-of-two-novel-oximes-k378-and-k727-in-comparison-to-k27-and-pralidoxime-against-paraoxon-ethyl-intoxication
#11
Maria Chaudhry, Muhammad Qaiser Fatmi, Kamil Musilek, Alamdar Hussain, Kamil Kuca, Georg Petroianu, Huba Kalasz, Syed Muhammad Nurulain
Organophosphate (OP) poisoning is a major global health issue; while compounds from this group have been used intensively over the last century, an effective antidote is still lacking. Oxime-type AChE reactivators are used to reactivate the OP inhibited AChE. Pralidoxime is the only US Food and Drug Administration, (FDA) approved oxime for therapeutic use but its efficacy has been disappointing. Two novel oximes (K378 and K727) were investigated in silico and in vitro and compared with an experimental oxime (kamiloxime; K-27) and pralidoxime...
July 19, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28697953/3d-in-vitro-models-of-liver-fibrosis
#12
Leo A van Grunsven
Animal testing is still the most popular preclinical assessment model for liver fibrosis. To develop efficient anti-fibrotic therapies, robust and representative in vitro models are urgently needed. The most widely used in vitro fibrosis model is the culture-induced activation of primary rodent hepatic stellate cells. While these cultures have contributed greatly to the current understanding of hepatic stellate cell activation, they seem to be inadequate to cover the complexity of this regenerative response...
July 8, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28675853/histopathological-effects-responses-of-oxidative-stress-inflammation-apoptosis-biomarkers-and-alteration-of-gene-expressions-related-to-apoptosis-oxidative-stress-and-reproductive-system-in-chlorpyrifos-exposed-common-carp-cyprinus-carpio-l
#13
Serdar Altun, Selçuk Özdemir, Harun Arslan
In this study, we aimed to identify the toxic effects of chlorpyrifos exposure on the tissues of common carp. For this purpose, we evaluated histopathological changes in the brain, gills, liver, kidney, testis, and ovaries after 21 days of chlorpyrifos exposure. Activation of 8-OHdG, cleaved caspase-3, and iNOS were assesed by immunofluorescence assay in chlorpyrifos-exposed brain and liver tissue. Additionally, we measured the expression levels of caspase-3, caspase-8, iNOS, MT1, CYP1A, and CYP3A genes in chlorpyrifos-exposed brain tissue, as well as the expression levels of FSH and LH genes in chlorpyrifos-exposed ovaries, using qRT-PCR...
November 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28641568/an-expanding-role-of-biomarkers-in-pulmonary-arterial-hypertension
#14
Mustafa Yildiz, Alparslan Sahin, Michael Behnes, İbrahim Akin
BACKGROUND: Pulmonary Arterial Hypertension (PAH) is a chronic disease which may cause or result from multiple cardiopulmonary disorders. The disease has complex pathophysiological mechanisms and involves many systematic, cellular and molecular changes. Therefore, it is crucial to find out underlying mechanisms and detect biomarkers to achieve early and proper diagnosis, evaluating disease severity, for follow-up and monitor response to treatment. Many biomarkers for PAH have been investigated but yet no such biomarker has been found specific and easily accessible to use for the patients...
2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28605001/determination-of-structural-femoral-head-allograft-viability-and-integrity-with-a-novel-diagnostic-tool-spect-ct-a-preliminary-study
#15
Kasım Kilicarslan, Nadir Yalcin, Vedat Bicici, Elif Ozdemir, Izzet Bingol, Seyda Turkolmez
OBJECTIVE: To evaluate the viability and integrity of fresh frozen bulk femoral head allografts obtained from the institutional bone bank that were used to reconstruct severe acetabular defects and to validate the SPECT/CT method which gives both anatomical and functional data for this purpose. METHODS: We retrospectively reviewed 9 patients (6 female, 3 male; mean age 63.6 years). Preoperative and postoperative leg lengths, existence of the Trendelenburg sign, range of motion of the hip, visual analogue score (VAS), Harris Hip Score (HHS) and any complication were assesed at each follow-up...
June 2, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28589667/in-vitro-and-in-vivo-assessment-of-lactic-acid-modified-chitosan-scaffolds-for-potential-treatment-of-full-thickness-burns
#16
Cristina Velasquillo, Phaedra Silva-Bermudez, Nadia Vázquez, Alan Martínez, Andres Espadín, Julieta García-López, Antonio Medina-Vega, Hugo Lecona, Raúl Pichardo-Baena, Clemente Ibarra, Keiko Shirai
Autologous skin transplantation is today's "gold standard" treatment for full-thickness burns. However, when > 30% of total body surface area is damaged, there is an important shortage of autologous donor sites for skin grafting; then, treatment alternatives become crucial. Such alternatives can be based on polymeric scaffolds capable of functioning as protective covers and cells/factors carriers. Chitosan (CTS) is a natural-derived polymer with relevant biological-related properties but poor mechanical performance...
June 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28589290/validation-of-a-single-summary-score-for-the-prolapse-incontinence-sexual-questionnaire-iuga-revised-pisq-ir
#17
Melissa L Constantine, Rachel N Pauls, Rebecca R Rogers, Todd H Rockwood
INTRODUCTION AND HYPOTHESIS: The Prolapse/Incontinence Sexual Questionnaire-International Urogynecology Association (IUGA) Revised (PISQ-IR) measures sexual function in women with pelvic floor disorders (PFDs) yet is unwieldy, with six individual subscale scores for sexually active women and four for women who are not. We hypothesized that a valid and responsive summary score could be created for the PISQ-IR. METHODS: Item response data from participating women who completed a revised version of the PISQ-IR at three clinical sites were used to generate item weights using a magnitude estimation (ME) and Q-sort (Q) approaches...
June 6, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28588752/inducible-protein-10-as-a-predictive-marker-of-antiviral-hepatitis-c-treatment-a-systematic-review
#18
REVIEW
Bastian Neesgaard, Morten Ruhwald, Nina Weis
AIM: To investigate interferon-γ-inducible protein-10's (IP-10) potential to anticipate rapid (RVR)- and sustained virological responses (SVR) to chronic hepatitis C (CHC) treatment. METHODS: We included case series examining RVR or SVR in relation to 24 or 48 wk treatment for CHC, in patients treatment free for at least six months, with genotype 1 or 4, and in relation to 24 wk treatment for genotype 2 and 3, with pegylated interferon in combination with ribavirin...
May 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28578081/expectant-management-of-gallbladder-stones-after-endoscopic-removal-of-common-bile-duct-stones
#19
Anne Mattila, Johanna Mrena, Ilmo Kellokumpu
BACKGROUND: Wait-and-see policy after endoscopic sphincterotomy (ES) for common bile duct (CBD) stones in patients with concomitant gallbladder stones may lead to recurrent biliary complications. The aim of this study was to assess the short and long-term results of wait-and-see policy in patients with intact gallbladder after endoscopic clearance of CBD stones. MATERIALS AND METHODS: From January 1999 to December 2014 a total of 181 consecutive patients with intact gallbladder underwent ES for CBD stones...
May 31, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28549793/clinical-residual-symptomatology-and-associated-factors-in-multiple-organ-failure-survivors-a-long-term-mortgage
#20
S Rodríguez-Villar, J L Rodríguez-García, J Arévalo-Serrano, M Sánchez-Casado, H Fletcher
PURPOSE: To evaluate which clinical residual symptoms, multiorgan failure (MOF) patients may exhibit following discharge from intensive care unit (ICU) and to identify the associated factors. MATERIAL AND METHODS: A total of 545 consecutively admitted adult patients with MOF on admission were included in the study. Patients were assesed by a survey 6 and 12 months after discharge from a medical-surgical ICU in Spain. A telephone survey was conducted concerning the clinical symptoms of their stay in ICU...
May 23, 2017: Revista Española de Anestesiología y Reanimación
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