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https://www.readbyqxmd.com/read/29792236/evaluation-of-gamma-radiation-induced-biochemical-changes-in-skin-for-dose-assesment-a-study-on-small-experimental-animals
#1
Sandeep Kumar Soni, Mitra Basu, Priyanka Agrawal, Aseem Bhatnagar, Neelam Chhillar
OBJECTIVE: Researchers have been evaluating several approaches to assess acute radiation injury/toxicity markers owing to radiation exposure. Keeping in mind this background, we assumed that whole-body irradiation in single fraction in graded doses can affect the antioxidant profile in skin that could be used as an acute radiation injury/toxicity marker. METHODS: Sprague-Dawley rats were treated with CO-60 gamma radiation (dose: 1-5 Gy; dose rate: 0.85 Gy/minute)...
May 24, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29787293/compulsive-sexual-behavior-a-twelve-step-therapeutic-approach
#2
Yaniv Efrati, Mateusz Gola
Background and aims Sexuality is natural to human life and inseparable from it, yet some individuals develop compulsive sexual behavior (CSB). Many individuals with CSB seek treatment in free self-support groups based on the twelve-step program. This program was extensively studied in substance abuse disorders (e.g., Alcoholics Anonymous), but little is known about its efficiency in CSB. Methods We "assesed" questionnaire data on sociodemographical-, psychological-, and recovery-related factors from 97 male participants of Sexaholics Anonymous (SA) programs in Israel...
May 22, 2018: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29771834/family-functions-and-life-quality-of-parents-of-children-with-cleft-lip-and-palate
#3
Belma I Aslan, Ayşe Gülşen, Şadiye B Tirank, Kemal Findikçioğlu, F Deniz Uzuner, Hakan Tutar, Neslihan Üçüncü
OBJECTIVE: This study was designed to identify variables affecting family functions and life quality of parents with cleft lip and/or palate children. MATERIALS AND METHODS: Family Assesment Scale (FAS) and short form of World Health Organization quality of life (WHOQOL-BREF-TR) were used to measure family functions and life quality of parents. Questionnaire Forms were given to 146 parents: 74 having cleft lip and/or palate children (cleft-group), and the other 72 with healthy children (control-group)...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29758935/blood-urea-nitrogen-bun-independently-predicts-mortality-in-critically-ill-patients-admitted-to-icu-a-multicenter-study
#4
Bernhard Wernly, Michael Lichtenauer, Namkje A R Vellinga, E Christiaan Boerma, Can Ince, Malte Kelm, Christian Jung
BACKGROUND AND PURPOSE: The Microcirculatory Shock Occurrence in Acutely Ill Patients (micro-SOAP) study investigated associations of microcirculation and mortality. Risk stratification in critically ill patients is of utmost interest. Established score such as APACHE2 (Acute Physiology And Chronic Health Evaluation 2) are relatively complex and might therefore be of limited use. Blood urea nitrogen (BUN) was described to be associated with mortality in various diseases. We therefore aimed (i) to evaluate BUN for prediction of mortality in a cohort of critically ill patients and (ii) to investigate associations of BUN with microcirculation...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29748449/risk-factors-of-tympanoplasties-in-long-term-observation
#5
Joanna Janiak-Kiszka, Wojciech Kaźmierczak, Kinga Lewandowska, Mateusz Grabowski, Henryk Kaźmierczak, Łukasz Kluczyński
OBJECTIVES: The aim of the study was to evaluate risk factors influencing the results of tympanoplasties on the base of material taken from the Department of Otolaryngology and Laryngological Oncology Collegium Medicum of Nicolaus Copernicus University in Bydgoszcz between 2004-2009. In this period 98 operations were done. The time from operation to hearing examination was 3 to 7 years, mean 5,43. Tympanoplastic operation were divided according to Tos classification. Measuring hearing results, tonal audiometry was done and mean air bone gap on four frequencies was assesed (500, 1000, 2000, 3000 Hz), according to AAO-HNS guidelines (1995)...
April 30, 2018: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29743761/predictors-of-mortality-in-acute-kidney-injury-patients-admitted-to-medicine-intensive-care-unit-in-a-rural-tertiary-care-hospital
#6
Amrish Saxena, Shrikant V Meshram
Background: Acute kidney injury (AKI) is a challenging problem faced by intensive care clinicians worldwide, and it is associated with high morbidity and mortality, especially in critically ill patients. Materials and Methods: A hospital-based prospective, observational study was conducted in patients of AKI admitted to the Intensive Care Unit (ICU) of the Department of Medicine in a rural tertiary care hospital located in central India. Data of all consecutive AKI inpatients related to demographic variables, clinical profile, and laboratory investigations were collected from patient's medical records...
April 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29722422/expression-of-plakophilin-3-in-diffuse-malignant-pleural-mesothelioma
#7
Silvija Mašić, Luka Brčić, Božo Krušlin, Ana Šepac, Biserka Pigac, Dinko Stančić-Rokotov, Marko Jakopović, Sven Seiwerth
Diffuse malignant pleural mesothelioma (DMPM) is the most common primary malignant pleural neoplasm still posing major diagnostic, prognostic and therapeutic challenges. Plakophilins are structural proteins considered to be important for cell stability and adhesion in both tumor and normal tissues. Plakophilin 3 is a protein present in desmosomes of stratified and simple epithelia of normal tissues with presence in malignant cells of various tumors where it participates in the process of tumorigenesis. The aim of this study was to investigate the expression of plakophilin 3 protein in DMPM, but also to study its prognostic significance and relation to histologically accessible parameters of aggressive growth...
May 3, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29686770/subacute-oral-toxicity-assesment-of-ethanol-extract-of-mariposa-christia-vespertilionis-leaves-in-male-sprague-dawley-rats
#8
Syahirah Ahmad Sayuti Nurul, Hamzah Hazilawati, Rosly Shaari Mohd, Farhan Hanif Reduan Mohd, Mohamed Mustapha Noordin, Md Esa Norhaizan
The term Butterfly tea refers to decoction of Mariposa christia vespertilionis leaves which is widely consumed by cancer patients throughout Malaysia and has gained a huge popularity among Malaysians, not only cancer patients but also researchers to discover the real potential of this plant. Herein, the study is aimed at evaluating the possible toxicity in 28-day subacute oral toxicity of ethanolic extract M. christia vespertilionis in male Sprague Dawley rats. The 28-day subacute toxicity study was conducted to detect the no-observed adverse effect level (NOAEL)...
April 2018: Toxicological Research
https://www.readbyqxmd.com/read/29651276/liposome-entrapment-of-bacteriophages-improves-wound-healing-in-a-diabetic-mouse-mrsa-infection
#9
Sanjay Chhibber, Jasjeet Kaur, Sandeep Kaur
Diabetic populations are more prone to developing wound infections which results in poor and delayed wound healing. Infection with drug resistant organisms further worsen the situation, driving searches for alternative treatment approaches such as phage therapy. Major drawback of phage therapy, however, is low phage persistence in situ , suggesting further refinement of the approach. In the present work we address this issue by employing liposomes as delivery vehicles. A liposome entrapped phage cocktail was evaluated for its ability to resolve a Staphylococcus aureus -induced diabetic excission wound infection...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29625941/antioxidant-capacity-and-polyphenolic-content-of-the-echinocystis-lobata-michx-torr-et-a-gray-flowers
#10
Irina Ielciu, Daniela Hanganu, Ramona Păltinean, Laurian Vlase, Michel Frédérich, Ana-Maria Gheldiu, Daniela Benedec, Gianina Crişan
Echinocystis lobata (Michx.) Torr. et A.Gray is a spontaneous species in the Romanian flora, lesser studied by scientific literature, but which has proved significant activities in traditional medicine. The present study is aimed to provide data on the polyphenolic compounds in the composition of the flowers of this species and to test their biological potential. Polyphenols were identified and quantified using an HPLC-MS method. Tested biological activities were the cytotoxic, anti-plasmodial and antioxidant ones...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29621764/right-ventricular-functions-in-pulmonary-thromboembolism
#11
Tarik Yildirim, Fatih Akın, Ibrahim Altun, Seda Yildirim, Ozcan Basaran, Mustafa Soylu
<br><br>this is a letter to editor We have read with great interest the paper entitled 'Subclinical Atherosclerosis in Patients with Prior Pulmonary Thromboembolism' Buyukterzi et al.1 is very important study. We have some suggestions about this trial. Firstly there are several echocardiographic parameters are available to determine right ventricular functions. Fractional area change (FAC), tricuspit annular plane systolic excursion (TAPSE), tissue Doppler derived right ventricular systolic excursion velocity S', strain and strain rate are the major determiner of right ventricular systolic functions...
April 5, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29561964/mid-term-results-of-surgical-treatment-of-atrial-fibrillation-in-valvular-heart-disease-assesed-by-speckle-tracking-echocardiography
#12
Natalia Lorenzo, Irene Mendez, Mikel Taibo, Gianfranco Martinis, Sara Badia, Guillermo Reyes, Rio Aguilar
BACKGROUND: Atrial fibrillation frequently affects patients with valvular heart disease. Ablation of atrial fibrillation during valvular surgery is an alternative for restoring sinus rhythm. OBJECTIVES: This study aimed to evaluate mid-term results of successful atrial fibrillation surgical ablation during valvular heart disease surgery, to explore left atrium post-ablation mechanics and to identify predictors of recurrence. METHODS: Fifty-three consecutive candidates were included...
April 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29498800/syncope-as-a-subject-of-the-risk-assessment-of-pulmonary-thromboembolism-to-be-used-for-a-cross-sectional-study
#13
Songul Ozyurt, Savas Ozsu, Muge Erbay, Funda Oztuna, Aziz Gumus, Unal Sahin
INTRODUCTION: Syncope is infrequent in pulmonary thromboembolism (PTE) yet might be indicative of haemodynamic instability. The prognostic role of syncope in PTE has not been well documented. OBJECTIVES: In this study, the association between risk classification of the European Society of Cardiology and syncope was investigated in the normotensive PTE patients. METHODS: We retrospectively screened electronic medical records of patients who were admitted in 2 tertiary care hospital and diagnosis of PTE with computed tomography pulmonary angiography...
March 2, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29487397/contemporary-approach-to-predict-early-biochemical-recurrence-after-radical-prostatectomy-update-of-the-walz-nomogram
#14
Raisa S Pompe, Marco Bandini, Felix Preisser, Michele Marchioni, Emanuele Zaffuto, Zhe Tian, Georg Salomon, Thorsten Schlomm, Hartwig Huland, Markus Graefen, Derya Tilki, Shahrokh F Shariat, Pierre I Karakiewicz
BACKGROUND: Early biochemical recurrence (eBCR) after radical prostatectomy (RP) heralds poor oncological outcomes and may be prevented with adjuvant radiation (aRT). METHODS: We developed a contemporary eBCR nomogram in 13 797 RP patients from Hamburg (2005-2016) and externally validated it in 5952 RP patients from Vienna. Receiver operating characteristics-derived area under the curve (AUC), Heagerty's C-index, and decision curve analysis (DCA) were used to quantify model accuracy and to compare the current tool with the Walz nomogram, the online Memorial Sloan Kettering Cancer Center (MSKCC) nomogram and the post-surgical Cancer of the Prostate Risk Assesment (CAPRA-S)...
February 27, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29477793/improved-sulfide-mitigation-in-sewers-through-on-line-control-of-ferrous-salt-dosing
#15
Ramon Ganigué, Guangming Jiang, Yiqi Liu, Keshab Sharma, Yue-Cong Wang, José Gonzalez, Tung Nguyen, Zhiguo Yuan
Water utilities worldwide spend annually billions of dollars to control sulfide-induced corrosion in sewers. Iron salts chemically oxidize and/or precipitate dissolved sulfide in sewage and are especially used in medium- and large-size sewers. Iron salt dosing rates are defined ad hoc, ignoring variation in sewage flows and sulfide levels. This often results in iron overdosing or poor sulfide control. Online dosing control can adjust the chemical dosing rates to current (and future) state of the sewer system, allowing high-precision, stable and cost-effective sulfide control...
May 15, 2018: Water Research
https://www.readbyqxmd.com/read/29444169/monitoring-chest-compression-quality-during-cardiopulmonary-resuscitation-proof-of-concept-of-a-single-accelerometer-based-feedback-algorithm
#16
Digna María González-Otero, Jesus María Ruiz, Sofía Ruiz de Gauna, Jose Julio Gutiérrez, Mohamud Daya, James Knox Russell, Izaskun Azcarate, Mikel Leturiondo
BACKGROUND: The use of real-time feedback systems to guide rescuers during cardiopulmonary resuscitation (CPR) significantly contributes to improve adherence to published resuscitation guidelines. Recently, we designed a novel method for computing depth and rate of chest compressions relying solely on the spectral analysis of chest acceleration. That method was extensively tested in a simulated manikin scenario. The purpose of this study is to report the results of this method as tested in human out-of-hospital cardiac arrest (OHCA) cases...
2018: PloS One
https://www.readbyqxmd.com/read/29435616/the-response-of-lemna-minor-to-mixtures-of-pesticides-that-are-commonly-used-in-thailand
#17
Rungnapa Tagun, Alistair B A Boxall
In the field, aquatic organisms are exposed to multiple contaminants rather than to single compounds. It is therefore important to understand the toxic interactions of co-occurring substances in the environment. The aim of the study was to assess the effects of individual herbicides (atrazine, 2,4-D, alachlor and paraquat) that are commonly used in Thailand and their mixtures on Lemna minor. Plants were exposed to individual and binary mixtures for 7 days and the effects on plant growth rate were assesed based on frond area measurements...
April 2018: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29428870/physiological-assesment-of-vestibular-function-and-toxicity-in-humans-and-animals
#18
Jordi Llorens, Angela Callejo, Erin A Greguske, Alberto F Maroto, Blanca Cutillas, Vanessa Martins-Lopes
Physiological methods that can be similarly recorded in humans and animals have a major role in sensory toxicology, as they provide a bridge between human sensory perception data and the molecular and cellular data obtained in animal studies. Vestibular toxicity research lags well behind other sensory systems in many aspects, including the availability of methods for functional assessment in animals that could be robustly translated to human significance. Here we review the methods available for the assessment of vestibular function in both humans and laboratory animals, with an emphasis on their similarity or divergence, to highlight their potential utility for the predictive assessment of vestibular toxicity...
February 8, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29416210/assesment-of-rhythm-disorders-in-classical-and-nonclassical-mitral-valve-prolapse
#19
Enisa Hodzic
Introduction: Mitral Valve Prolapse (MVP) is the most common cardiac valve pathology of to day. Aim of article was to identify the types and frequency of potentially malignant arrhythmia and atrial brillation in patients with MVP, to determine the differences in these arrhythmias between classical and non-classical MVP, to evaluate the correlation of potentially malignant arrhythmia and atrial fibrillation with MVP with possible clinical complications of arrhythmogenic sudden cardiac death and potential risk of thromboembolic vascular incident...
February 2018: Medical Archives
https://www.readbyqxmd.com/read/29414093/ultrasensitive-direct-impedimetric-immunosensor-for-detection-of-serum-her2
#20
Shikha Sharma, Julia Zapatero-Rodríguez, Rahul Saxena, Richard O'Kennedy, Sudha Srivastava
Assesment of human epidermal growth factor receptor 2 status is a key factor prompting definitive treatment decisions that help in reducing mortality rates associated with breast cancer. In this article, highly sensitive and low-cost impedimetric immunosensor using single-chain fragment variable antibody fragments was developed for quantitative detection of human epidermal growth factor receptor 2 from serum employing gold nanoparticle-modified disposable screen-printed carbon electrodes. The gold nanoparticles facilitate fast electron transfer and offer a biocompatible surface for immobilization of small antibody fragments in an oriented manner, resulting in improved antigen binding efficiency...
May 30, 2018: Biosensors & Bioelectronics
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