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https://www.readbyqxmd.com/read/29444169/monitoring-chest-compression-quality-during-cardiopulmonary-resuscitation-proof-of-concept-of-a-single-accelerometer-based-feedback-algorithm
#1
Digna María González-Otero, Jesus María Ruiz, Sofía Ruiz de Gauna, Jose Julio Gutiérrez, Mohamud Daya, James Knox Russell, Izaskun Azcarate, Mikel Leturiondo
BACKGROUND: The use of real-time feedback systems to guide rescuers during cardiopulmonary resuscitation (CPR) significantly contributes to improve adherence to published resuscitation guidelines. Recently, we designed a novel method for computing depth and rate of chest compressions relying solely on the spectral analysis of chest acceleration. That method was extensively tested in a simulated manikin scenario. The purpose of this study is to report the results of this method as tested in human out-of-hospital cardiac arrest (OHCA) cases...
2018: PloS One
https://www.readbyqxmd.com/read/29435616/the-response-of-lemna-minor-to-mixtures-of-pesticides-that-are-commonly-used-in-thailand
#2
Rungnapa Tagun, Alistair B A Boxall
In the field, aquatic organisms are exposed to multiple contaminants rather than to single compounds. It is therefore important to understand the toxic interactions of co-occurring substances in the environment. The aim of the study was to assess the effects of individual herbicides (atrazine, 2,4-D, alachlor and paraquat) that are commonly used in Thailand and their mixtures on Lemna minor. Plants were exposed to individual and binary mixtures for 7 days and the effects on plant growth rate were assesed based on frond area measurements...
February 13, 2018: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29428870/physiological-assesment-of-vestibular-function-and-toxicity-in-humans-and-animals
#3
Jordi Llorens, Angela Callejo, Erin A Greguske, Alberto F Maroto, Blanca Cutillas, Vanessa Martins-Lopes
Physiological methods that can be similarly recorded in humans and animals have a major role in sensory toxicology, as they provide a bridge between human sensory perception data and the molecular and cellular data obtained in animal studies. Vestibular toxicity research lags well behind other sensory systems in many aspects, including the availability of methods for functional assessment in animals that could be robustly translated to human significance. Here we review the methods available for the assessment of vestibular function in both humans and laboratory animals, with an emphasis on their similarity or divergence, to highlight their potential utility for the predictive assessment of vestibular toxicity...
February 8, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29416210/assesment-of-rhythm-disorders-in-classical-and-nonclassical-mitral-valve-prolapse
#4
Enisa Hodzic
Introduction: Mitral Valve Prolapse (MVP) is the most common cardiac valve pathology of to day. Aim of article was to identify the types and frequency of potentially malignant arrhythmia and atrial brillation in patients with MVP, to determine the differences in these arrhythmias between classical and non-classical MVP, to evaluate the correlation of potentially malignant arrhythmia and atrial fibrillation with MVP with possible clinical complications of arrhythmogenic sudden cardiac death and potential risk of thromboembolic vascular incident...
February 2018: Medical Archives
https://www.readbyqxmd.com/read/29414093/ultrasensitive-direct-impedimetric-immunosensor-for-detection-of-serum-her2
#5
Shikha Sharma, Julia Zapatero-Rodríguez, Rahul Saxena, Richard O'Kennedy, Sudha Srivastava
Assesment of human epidermal growth factor receptor 2 status is a key factor prompting definitive treatment decisions that help in reducing mortality rates associated with breast cancer. In this article, highly sensitive and low-cost impedimetric immunosensor using single-chain fragment variable antibody fragments was developed for quantitative detection of human epidermal growth factor receptor 2 from serum employing gold nanoparticle-modified disposable screen-printed carbon electrodes. The gold nanoparticles facilitate fast electron transfer and offer a biocompatible surface for immobilization of small antibody fragments in an oriented manner, resulting in improved antigen binding efficiency...
January 31, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29386154/assesment-of-predictor-variables-and-clinical-consequences-associated-with-surgical-site-infection-in-tertiary-care-setting-karachi-pakistan
#6
Anum Tariq, Huma Ali, Farya Zafar, Ali Akbar Sial, Kamran Hameed, Mehwish Rizvi, Rabia Bushra, Saima Salim, Zeb-Un Nisa, Ghazala R Naqvi, Saba Zubair
Among the well-known Health care-associated infections (HAIs), surgical site infections (SSIs) contribute to considerable high mortality and morbidity rate, substantial prolongation in hospitalization period and extra expenses in terms of treatment cost. This study was aimed to evaluate the predictive variables associated with surgical site infections, and their clinical consequences. This was a prospective, cross sectional study conducted in the surgical department of tertiary care setting in Karachi, Pakistan...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29374405/shortwave-infrared-raman-spectroscopic-classification-of-water-fractions-in-articular-cartilage-ex-vivo
#7
Mustafa Unal, Ozan Akkus
Water loss is an early onset indicator of osteoarthritis. Although Raman spectroscopy (RS) holds the potential for measurement of cartilage hydration, the knowledge of Raman OH-stretch bands of biological tissue is very limited. We assesed here the sensitivity of RS to identify and classify water types in the cartilage. Raman spectrum measurements over the high wavenumber range were employed to identify different water fractions in articular cartilage. Raman spectra were collected from wet and sequentially dehydrated cartilage along with pure collagen type II and chondroitin sulfate standards...
January 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29364458/nail-psoriasis-treated-with-pulsed-dye-laser
#8
Juliano Peruzzo, Gabriela Czarnobay Garbin, Gabriela Maldonado, Tania Ferreira Cestari
Nail changes are present in about 50% of psoriasis patients and tend to be refractory to conventional treatments. Pulsed dye laser has emerged as an alternative therapy. Our aim is to evaluate the efficacy of pulsed dye laser in nail psoriasis and the impact of treatment on quality of life. Fourteen patients were treated in monthly sessions for three months. The outcome assesment was made by the Nail Psoriasis Severity Index (NAPSI). The median improvement in the scores of the overall NAPSI, nail bed NAPSI, and nail matrix NAPSI were 44...
November 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29333039/pharmacognostic-assesment-of-the-endemic-and-vulnerable-medicinal-climber-cayratia-pedata-lam-gagnep-var-glabra-gamble-and-its-antibacterial-activity
#9
S Sharmila, K Kalaichelvi, S M Dhivya, P Premamalini, P Abirami, G Jayanthi
Objective: The objective of this study is to evaluate a meticulous pharmacognostic cram is to supplement constructive information with regard to its identification, characterization, and standardization of endemic and endangered medicinal climber Cayratia pedata var. glabra and also screening the antibacterial activity of this climber. Materials and Methods: The morphological characters of study plant, microscopic examination of leaf powder, anatomy of young stem, physicochemical analysis of plant powder, extractive values, phytochemical analysis, powder with different chemical reagents, fluorescence analysis of plant powder, and other World Health Organization (WHO) recommended for standardization were analyzed...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29329713/baseline-and-pre-operative-1-year-mortality-risk-factors-in-a-cohort-of-509-hip-fracture-patients-consecutively-admitted-to-a-co-managed-orthogeriatric-unit-fonda-cohort
#10
Rocío Menéndez-Colino, Teresa Alarcon, Pilar Gotor, Rocío Queipo, Raquel Ramírez-Martín, Angel Otero, Juan I González-Montalvo
INTRODUCTION: The aim of this study was to determine the patient characteristics that predict 1-year mortality after a hip fracture (HF). METHODS: All patients admitted consecutively with fragility HF during 1 year in a co-managed orthogeriatric unit of a university hospital (FONDA cohort) were assesed. Baseline and admission demographic, clinical, functional, analytical and body-composition variables were collected in the first 72 h after admission. A protocol designed to minimize the consequences of the HF was applied...
January 6, 2018: Injury
https://www.readbyqxmd.com/read/29319139/the-role-of-99mtc-dtpa-retrobulbar-spect-in-staging-and-follow-up-of-graves-orbitopathy
#11
László Galuska, Sándor Barna, József Varga, Ildikó Garai, Endre V Nagy
The pathogenesis of Graves' orbitopathy (GO) is not completely understood. Coexistent hyperfunction of the thyroid gland is frequent; however, GO may also coexist with hypo- or euthyrodism. The course of GO is largely independent of thyroid function, although elevated serum TSH is known to negatively interfere with GO course. GO is severe in 10 % of the cases; sight threatening complications may also develop. A successful therapy of GO requires the assesment of both the severity and activity of orbital inflammation...
January 10, 2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29288881/a-novel-screening-method-to-identify-late-stage-dementia-patients-for-palliative-care-research-and-practice
#12
Natalie C Ernecoff, Kathryn L Wessell, Stacey Gabriel, Timothy S Carey, Laura C Hanson
CONTEXT: Investigators need novel methods for timely identification of patients with serious illness to test or implement new palliative care models. OBJECTIVE: The study aim was to develop an electronic health record (EHR) phenotype to identify patients with late-stage dementia for a clinical trial of palliative care consultation. METHODS: We developed a computerized method to identify patients with dementia on hospital admission. Within a data warehouse derived from the hospital's EHR, we used search terms of age, admission date, and ICD-9 and ICD-10 diagnosis codes to create a EHR dementia phenotype, followed by brief medical record review to confirm late-stage dementia...
December 27, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29284941/a-comparative-evaluation-of-bifidobacteria-levels-in-early-childhood-caries-and-severe-early-childhood-caries
#13
Suraj Nair, V Suresh Kumar, Ramesh Krishnan, Pooja Rajan
Background: Bifidobacteria levels in saliva were found to be significantly correlated in adults with dental caries but less information available in the literature regarding its role in children. Aim: The aim is to compare the salivary levels of Bifidobacteria in children who are caries free with that of early childhood caries (ECC) and severe ECC (S-ECC). Materials and Methods: Saliva was collected using the tongue-loop method from a total of 60 children between the age group of 3-5 years and they were further divided into 3 groups...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29219062/assesment-of-irisin-adiponectin-and-leptin-levels-in-patients-with-schizophrenia
#14
Gamze Erzin, Canan Topcuoglu, Vahap Ozan Kotan, Senol Bayram, Kostas Fountoulakis
BACKGROUND: The patients with schizophrenia are at increased risk for problems regarding metabolic parameters due to their lifestyle and antipsychotic treatment. OBJECTIVE: In this study, we aimed to evaluate the levels of adiponectin, leptin, irisin in patients with schizophrenia who were nondiabetic, nonobese and under antipsychotic treatment. METHOD: 5 ml sample of venous blood was collected from each participant. Blood cells were separated from the serum...
December 7, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29199640/effects-of-humidity-co-sub-2-sub-and-o-sub-2-sub-on-real-time-quantitation-of-breath-biomarkers-by-means-of-ptr-tof-ms
#15
Phillip Trefz, Jochen Schubert, Wolfram Miekisch
Proton-transfer-reaction-time-of-flight-mass-spectrometry (PTR-ToF-MS) represents an attractive tool for real-time analysis of VOC profiles in human breath. Quantification of breath VOCs by means of direct MS may be affected by the matrix as human breath does not only contains several hundred VOCs in the ppbV-pptV level but is water saturated and contains percentage levels of CO2. Investigation of breath biomarkers in clinical studies requires quantitative and comparable results. We, therefore, assesed systematically the effect of humidity, CO2 and O2 onto the results of PTR-MS analysis...
December 4, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29185863/comparison-of-the-diastereoisomeric-excess-of-uridine-inosine-and-adenosine-cyanohydrins-determined-by-hplc-dad-and-1h-nmr
#16
Rubria Marlen Martínez-Casares, Herminia Inés Pérez Méndez, Norberto Manjarrez Alvarez, Aida Solís Oba, Liliana Hernández Vázquez, Alberto López-Luna
The separation of the diastereoisomers of the nucleoside derivatives of uridine, inosine and adenosine was performed by HPLC using chiral and no chiral columns, it was observed with the no chiral columns the resolution was good enough to determine diastereoisomeric excess. These methods were compared with 1H NMR, and no significant differences were observed between the three techniques. Diastereoisomeric uridine (3a), inosine (3b) and adenosine (4c) cyanohydrins were resolved by 1H nuclear magnetic resonance (1H NMR), chiral normal phase-high-performance liquid chromatography-diode array detector (NP-HPLC-DAD) and reversed phase (RP-HPLC-DAD); these methods allowed the assesment of the percent diastereoisomeric excess (% de) of the nucleosidic cyanohydrins of 3a (4, 6 and 4), 3b (10, 8 and 6) and 4c (4, 4 and 4)...
November 29, 2017: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/29153369/retrospective-comparison-of-three-dimensional-imaging-sequences-in-the-visualization-of-posterior-fossa-cranial-nerves
#17
Suna Ors, Ercan Inci, Rustu Turkay, Atilla Kokurcan, Elif Hocaoglu
PURPOSE: To compare efficancy of three-dimentional SPACE (sampling perfection with application-optimized contrasts using different flip-angle evolutions) and CISS (constructive interference in steady state) sequences in the imaging of the cisternal segments of cranial nerves V-XII. METHODS: Temporal MRI scans from 50 patients (F:M ratio, 27:23; mean age, 44.5±15.9 years) admitted to our hospital with vertigo, tinnitus, and hearing loss were retrospectively analyzed...
December 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29149679/innovative-urban-forestry-governance-in-melbourne-investigating-green-placemaking-as-a-nature-based-solution
#18
Natalie Marie Gulsrud, Kelly Hertzog, Ian Shears
A nature-based approach to climate resilience aims to challenge and re-frame conventional environmental management methods by refocusing solutions from technological strategies to socio-ecological principles such as human well-being and community-based governance models, thereby improving and legitimizing the delivery of ecosystem services (ES). There are, however, many challenges to applying a socio-ecological agenda to urban climate resilience and thereby re-framing ES delivery as community and people focused, a knowledge gap extensively outlined in the environmental governance literature...
November 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/29120410/molecular-analysis-of-axonal-intrinsic-and-glial-associated-co-regulation-of-axon-degeneration
#19
Alejandra Catenaccio, Maica Llavero Hurtado, Paula Diaz, Douglas J Lamont, Thomas M Wishart, Felipe A Court
Wallerian degeneration is an active program tightly associated with axonal degeneration, required for axonal regeneration and functional recovery after nerve damage. Here we provide a functional molecular foundation for our undertstanding of the complex non-cell autonomous role of glial cells in the regulation of axonal degeneration. To shed light on the complexity of the molecular machinery governing axonal degeneration we employ a multi-model, unbiased, in vivo approach combining morphological assesment and quantitative proteomics with in silico-based higher order functional clustering to genetically uncouple the intrinsic and extrinsic processes governing Wallerian degeneration...
November 9, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29031037/-evaluation-of-anti-cancer-therapies-with-reimbursement-limited-to-comprehensive-cancer-centres-using-the-european-society-for-medical-oncology-magnitude-of-clinical-benefit-scale
#20
T Büchler, B Melichar, D Vrána, R Lemstrová, J Fínek, L Dušek, K Petráková, J Prausová
BACKGROUND: The costs of oncology treatments are increasing, due to the rising prevalence of malignant diseases and the introduction of expensive novel anti-cancer agents. The new European Society for Clinical Oncology (ESMO) has recently developed a new parametric system to evaluate the clinical benefit of drugs. The Magnitude of Clinical Benefit Scale (ESMO-MCBS) compares the contribution of a novel drug based on overall and progression-free survival and quality of life with those of current treatment options...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
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