Chang Xu, Yali Liu, Jiayan Li, Peng Ning, Zhong Shi, Wei Zhang, Zhenguang Li, Ruimei Zhou, Yifan Tong, Yingze Li, Cheng Lv, Yajing Shen, Qian Cheng, Bin He, Yu Cheng
Nanomachines with active propulsion have emerged as an intelligent platform for targeted cancer therapy. Achieving an efficient locomotion performance using an external energy conversion is a key requirement in the design of nanomachines. In this study, inspired by diverse spiky structures in nature, a photomagnetically powered nanomachine (PMN) with a spiky surface and thermally dependent viscosity tunability is proposed to facilitate mechanical motion in lysosomes for cancer mechanotherapy. The hybrid nanomachine is integrated with magnetic nanoparticles as the core and covered with gold nanotips...
February 2023: Advanced Materials