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Stroke neurorehabilitation

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https://www.readbyqxmd.com/read/27884966/setting-up-a-neuroscience-stroke-and-rehabilitation-centre-in-brunei-darussalam-by-a-transcontinental-on-site-and-telemedical-cooperation
#1
U Meyding-Lamadé, B Bassa, E Craemer, C Jacobi, C Chan, W Hacke, B Kress
Due to the world-wide aging population, there is a need for specialist neurological knowledge, treatment and care. Stroke treatment is effective in reducing mortality and disability, but it is still not available in many areas of the world. We describe the set-up process of a specialized Neuroscience, Stroke and Rehabilitation Centre in Brunei Darussalam (BNSRC) in cooperation with a German hospital. This study details the setup of a stroke-, neurological intensive care- and neurorehabilitation unit, laboratories and a telemedical network to perform all evidence-based stroke treatments...
November 24, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27871449/botulinum-toxin-as-early-intervention-for-spasticity-after-stroke-or-non-progressive-brain-lesion-a-meta-analysis
#2
Raymond L Rosales, Fran Efendy, Ericka Sa Teleg, Mary Md Delos Santos, Mary Ce Rosales, Marc Ostrea, Michelle J Tanglao, Arlene R Ng
Spasticity is a functionally limiting disorder that commonly occurs following stroke or severe brain injury, and may lead to disability and pain. In tandem with neurorehabilitation, botulinum toxin type A (BoNT-A) is the recommended first-line treatment for spasticity and, to date, the majority of trials have reported BoNT-A use in patients >6months after ictus. The present meta-analysis aimed to evaluate the effects of early BoNT-A injection for post-stroke spasticity on improvements in hypertonicity, disability, function and associated pain...
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27861901/chloride-co-transporters-as-possible-therapeutic-targets-for-stroke
#3
REVIEW
Miguel A S Martín-Aragón Baudel, Amy V Poole, Mark G Darlison
Stroke is one of the major causes of death and disability worldwide. The major type of stroke is an ischaemic one, which is caused by a blockage that interrupts blood flow to the brain. There are currently very few pharmacological strategies to reduce the damage and social burden triggered by this pathology. The harm caused by the interruption of blood flow to the brain unfolds in the subsequent hours and days, so it is critical to identify new therapeutic targets that could reduce neuronal death associated with the spread of the damage...
November 15, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27858095/-new-aspects-of-neurorehabilitation-motor-and-language
#4
J Liepert, C Breitenstein
Advancements in medical care over the last decades have contributed to a continuous decline in immediate post-stroke mortality. The flipside of this development is that patients surviving the initial stroke are forced to live with sometimes extreme functional motor and/or language limitations for the remaining life span. The following overview presents evidence-based neurorehabilitative interventions to promote motor and language recovery in the acute and chronic post-stroke stages. Therapeutic approaches comprise intensive training, neuropharmacological drugs and non-invasive brain stimulation techniques, such as transcranial magnetic stimulation (TMS) or direct current stimulation (tDCS)...
November 17, 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27846623/paracrine-mechanisms-of-intravenous-bone-marrow-derived-mononuclear-stem-cells-in-chronic-ischemic-stroke
#5
Ashu Bhasin, M V Padma Srivastava, Sujata Mohanty, Sivasubramaniam Vivekanandhan, Sakshi Sharma, Senthil Kumaran, Rohit Bhatia
BACKGROUND: The emerging role of stem cell technology and transplantation has helped scientists to study their potential role in neural repair and regeneration. The fate of stem cells is determined by their niche, consisting of surrounding cells and the secreted trophic growth factors. This interim report evaluates the safety, feasibility and efficacy (if any) of bone marrow-derived mononuclear stem cells (BM-MNC) in chronic ischemic stroke by studying the release of serum vascular endothelial growth factor (VEGF) and brain-derived neurotrophic growth factor (BDNF)...
October 19, 2016: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/27826223/self-paced-reaching-after-stroke-a-quantitative-assessment-of-longitudinal-and-directional-sensitivity-using-the-h-man-planar-robot-for-upper-limb-neurorehabilitation
#6
Asif Hussain, Aamani Budhota, Charmayne Mary Lee Hughes, Wayne D Dailey, Deshmukh A Vishwanath, Christopher W K Kuah, Lester H L Yam, Yong J Loh, Liming Xiang, Karen S G Chua, Etienne Burdet, Domenico Campolo
Technology aided measures offer a sensitive, accurate and time-efficient approach for the assessment of sensorimotor function after neurological insult compared to standard clinical assessments. This study investigated the sensitivity of robotic measures to capture differences in planar reaching movements as a function of neurological status (stroke, healthy), direction (front, ipsilateral, contralateral), movement segment (outbound, inbound), and time (baseline, post-training, 2-week follow-up) using a planar, two-degrees of freedom, robotic-manipulator (H-Man)...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27818001/simultaneous-eeg-fnirs-reveals-how-age-and-feedback-affect-motor-imagery-signatures
#7
Catharina Zich, Stefan Debener, Ann-Kathrin Thoene, Ling-Chia Chen, Cornelia Kranczioch
Stroke frequently results in motor impairment. Motor imagery (MI), the mental practice of movements, has been suggested as a promising complement to other therapeutic approaches facilitating motor rehabilitation. Of particular potential is the combination of MI with neurofeedback (NF). However, MI NF protocols have been largely optimized only in younger healthy adults, although strokes occur more frequently in older adults. The present study examined the influence of age on the neural correlates of MI supported by electroencephalogram (EEG)-based NF and on the neural correlates of motor execution...
October 15, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27790612/muscle-synergies-facilitate-computational-prediction-of-subject-specific-walking-motions
#8
Andrew J Meyer, Ilan Eskinazi, Jennifer N Jackson, Anil V Rao, Carolynn Patten, Benjamin J Fregly
Researchers have explored a variety of neurorehabilitation approaches to restore normal walking function following a stroke. However, there is currently no objective means for prescribing and implementing treatments that are likely to maximize recovery of walking function for any particular patient. As a first step toward optimizing neurorehabilitation effectiveness, this study develops and evaluates a patient-specific synergy-controlled neuromusculoskeletal simulation framework that can predict walking motions for an individual post-stroke...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27788679/visually-guided-gait-training-in-paretic-patients-during-the-first-rehabilitation-phase-study-protocol-for-a-randomized-controlled-trial
#9
Cathia Rossano, Philippe Terrier
BACKGROUND: After a lesion to the central nervous system, many patients suffer from reduced walking capability. In the first rehabilitation phase, repeated walking exercises facilitate muscular strength and stimulate brain plasticity and motor relearning. However, marked limping, an unsteady gait, and poor management of obstacle clearance may persist, which increases a patient's risk of falling. Gait training with augmented reality has been recommended to improve gait coordination. The objective of this study is to test whether a gait rehabilitation program using augmented reality is superior to a conventional treadmill training program of equivalent intensity...
October 27, 2016: Trials
https://www.readbyqxmd.com/read/27778158/neurorehabilitation-applied-neuroplasticity
#10
Fary Khan, Bhasker Amatya, Mary P Galea, Roman Gonzenbach, Jürg Kesselring
The prevalence of disability due to neurological conditions is escalating worldwide. Neurological disorders have significant disability-burden with long-term functional and psychosocial issues, requiring specialized rehabilitation services for comprehensive management, especially treatments tapping into brain recovery 'neuroplastic' processes. Neurorehabilitation is interdisciplinary and cross-sectorial, requiring coordinated effort of diverse sectors, professions, patients and community to manage complex condition-related disability...
October 24, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27747108/mri-biomarkers-for-hand-motor-outcome-prediction-and-therapy-monitoring-following-stroke
#11
U Horn, M Grothe, M Lotze
Several biomarkers have been identified which enable a considerable prediction of hand-motor outcome after cerebral damage already in the subacute stage after stroke. We here review the value of MRI biomarkers in the evaluation of corticospinal integrity and functional recruitment of motor resources. Many of the functional imaging parameters are not feasible early after stroke or for patients with high impairment and low compliance. Whereas functional connectivity parameters have demonstrated varying results on their predictive value for hand-motor outcome, corticospinal integrity evaluation using structural imaging showed robust and high predictive power for patients with different levels of impairment...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/27726645/upper-extremity-proprioception-after-stroke-bridging-the-gap-between-neuroscience-and-rehabilitation
#12
Sonja E Findlater, Sean P Dukelow
Proprioception is an important aspect of function that is often impaired in the upper extremity following stroke. Unfortunately, neurorehabilitation has few evidence based treatment options for those with proprioceptive deficits. The authors consider potential reasons for this disparity. In doing so, typical assessments and proprioceptive intervention studies are discussed. Relevant evidence from the field of neuroscience is examined. Such evidence may be used to guide the development of targeted interventions for upper extremity proprioceptive deficits after stroke...
October 11, 2016: Journal of Motor Behavior
https://www.readbyqxmd.com/read/27718640/targeted-upper-limb-wii-based-movement-therapy-also-improves-lower-limb-muscle-activation-and-functional-movement-in-chronic-stroke
#13
Terry Trinh, Christine T Shiner, Angelica G Thompson-Butel, Penelope A McNulty
PURPOSE: Post-stroke hemiparesis may manifest as asymmetric gait, poor balance, and inefficient movement patterns. We investigated improvements in lower-limb muscle activation and function during Wii-based Movement Therapy (WMT), a rehabilitation program specifically targeting upper-limb motor-function. METHODS: Electromyography (EMG) was recorded bilaterally from tibialis anterior (TA) in 20 stroke patients during a 14-day WMT program. EMG amplitude and burst duration were analyzed during stereotypical movement sequences of WMT activities...
October 9, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27706248/democratizing-neurorehabilitation-how-accessible-are-low-cost-mobile-gaming-technologies-for-self-rehabilitation-of-arm-disability-in-stroke
#14
Paul Rinne, Michael Mace, Tagore Nakornchai, Karl Zimmerman, Susannah Fayer, Pankaj Sharma, Jean-Luc Liardon, Etienne Burdet, Paul Bentley
Motor-training software on tablets or smartphones (Apps) offer a low-cost, widely-available solution to supplement arm physiotherapy after stroke. We assessed the proportions of hemiplegic stroke patients who, with their plegic hand, could meaningfully engage with mobile-gaming devices using a range of standard control-methods, as well as by using a novel wireless grip-controller, adapted for neurodisability. We screened all newly-diagnosed hemiplegic stroke patients presenting to a stroke centre over 6 months...
2016: PloS One
https://www.readbyqxmd.com/read/27676993/can-tendon-vibration-therapy-improve-motor-recovery-in-the-arm-following-stroke-a-pilot-feasibility-study-of-a-clinical-protocol-in-11%C3%A2-patients
#15
Simon Butet, Clément Provost, Marylène Jousse, Leila Tlili, Victorine Quintaine, Isabelle Bonan, Alain Yelnik
OBJECTIVE: The positive effects on motor cortical excitability of stimulating proprioception with tendon vibration therapy have previously been reported in healthy individuals and in chronic stroke patient (Marconi et al., 2008 and 2011). The aim of this study is to evaluate the feasibility of a protocol of tendon vibration therapy in a neurorehabilitation service, with a view to proceeding to an efficacy study. MATERIAL/PATIENTS AND METHODS: We performed a prospective, single-centre study, including 11 patients, 8 men, mean age 61,7±10,6, with upper limb motor deficit secondary to a first stroke (5 ischaemic)...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27661010/four-birds-with-one-stone-reparative-neuroplastic-cardiorespiratory-and-metabolic-benefits-of-aerobic-exercise-poststroke
#16
Michelle Ploughman, Liam P Kelly
PURPOSE OF REVIEW: Converging evidence from animal models of stroke and clinical trials suggests that aerobic exercise has effects across multiple targets. RECENT FINDINGS: The subacute phase is characterized by a period of heightened neuroplasticity when aerobic exercise has the potential to optimize recovery. In animals, low intensity aerobic exercise shrinks lesion size and reduces cell death and inflammation, beginning 24 h poststroke. Also in animals, aerobic exercise upregulates brain-derived neurotrophic factor near the lesion and improves learning...
December 2016: Current Opinion in Neurology
https://www.readbyqxmd.com/read/27616992/a-comparative-analysis-of-2d-and-3d-tasks-for-virtual-reality-therapies-based-on-robotic-assisted-neurorehabilitation-for-post-stroke-patients
#17
Luis D Lledó, Jorge A Díez, Arturo Bertomeu-Motos, Santiago Ezquerro, Francisco J Badesa, José M Sabater-Navarro, Nicolás García-Aracil
Post-stroke neurorehabilitation based on virtual therapies are performed completing repetitive exercises shown in visual electronic devices, whose content represents imaginary or daily life tasks. Currently, there are two ways of visualization of these task. 3D virtual environments are used to get a three dimensional space that represents the real world with a high level of detail, whose realism is determinated by the resolucion and fidelity of the objects of the task. Furthermore, 2D virtual environments are used to represent the tasks with a low degree of realism using techniques of bidimensional graphics...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27595123/concomitant-use-of-neuroprotective-drugs-in-neuro-rehabilitation-of-multiple-sclerosis
#18
Harika Dasari, Bharath Wootla, Arthur E Warrington, Moses Rodriguez
We provide an overview of rehabilitation in neurological diseases. A large amount of literature available on neurorehabilitation is based from the rehabilitative work on stroke and spinal cord injuries. After a brief description of rehabilitation, the potential application of neurorehabilitation in neurodegenerative diseases specifically multiple sclerosis (MS) is summarized. Since MS causes a wide variety of symptoms, the rehabilitation in MS patients may benefit from an interdisciplinary approach that encloses physiotherapy, cognitive rehabilitation, psychological therapy, occupational therapy, and other methods to improve fatigue...
August 2016: International Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27592596/changing-their-minds-enhancing-poststroke-occupational-performance-using-transcranial-direct-current-stimulation
#19
Heather T Peters, Lorie Richards, Brittani A Basobas, Julie M Faieta, Stephen J Page
Stroke remains a leading cause of disability, with survivors experiencing long-term decrements in independence and quality of life. Occupational therapists (OTs) employ numerous neurorehabilitative treatment approaches to remediate impairments that are impeding performance. OTs also use physical agent modalities to facilitate increased participation and success in therapy. One such modality is transcranial direct current stimulation (tDCS), a form a noninvasive brain stimulation that can be overlaid onto task practice and delivers a constant, low intensity current into the brain...
September 3, 2016: Journal of Motor Behavior
https://www.readbyqxmd.com/read/27590975/interfacing-brain-with-computer-to-improve-communication-and-rehabilitation-after-brain-damage
#20
A Riccio, F Pichiorri, F Schettini, J Toppi, M Risetti, R Formisano, M Molinari, L Astolfi, F Cincotti, D Mattia
Communication and control of the external environment can be provided via brain-computer interfaces (BCIs) to replace a lost function in persons with severe diseases and little or no chance of recovery of motor abilities (ie, amyotrophic lateral sclerosis, brainstem stroke). BCIs allow to intentionally modulate brain activity, to train specific brain functions, and to control prosthetic devices, and thus, this technology can also improve the outcome of rehabilitation programs in persons who have suffered from a central nervous system injury (ie, stroke leading to motor or cognitive impairment)...
2016: Progress in Brain Research
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