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https://www.readbyqxmd.com/read/29243995/the-relationship-of-erectile-dysfunction-and-subclinical-cardiovascular-disease-a-systematic-review-and-meta-analysis
#1
Chukwuemeka U Osondu, Bryan Vo, Ebenezer T Oni, Michael J Blaha, Emir Veledar, Theodore Feldman, Arthur S Agatston, Khurram Nasir, Ehimen C Aneni
Erectile dysfunction (ED) is associated with cardiovascular disease (CVD) and CVD mortality. However, the relationship between ED and subclinical CVD is less clear. We synthesized the available data on the association of ED and measures of subclinical CVD. We searched multiple databases for published literature on studies examining the association of ED and measures of subclinical CVD across four domains: endothelial dysfunction measured by flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), coronary artery calcification (CAC), and other measures of vascular function such as the ankle-brachial index, toe-brachial index, and pulse wave velocity...
December 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/29243398/venous-leg-ulcer-management-in-clinical-practice-in-the-uk-costs-and-outcomes
#2
Julian F Guest, Graham W Fuller, Peter Vowden
The aim of this study was to estimate the patterns of care and annual levels of health care resource use attributable to managing venous leg ulcers (VLUs) in clinical practice by the UK's National Health Service (NHS) and the associated costs of patient management. This was a retrospective cohort analysis of the records of 505 patients in The Health Improvement Network (THIN) Database. Patients' characteristics, wound-related health outcomes and health care resource use were quantified, and the total NHS cost of patient management was estimated at 2015/2016 prices...
December 15, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29242843/systemic-oxidoreductive-balance-and-vascular-function-in-individuals-without-clinical-manifestation-of-atherosclerosis
#3
Marcin Majer, Daniel Gackowski, Rafał Różalski, Agnieszka Siomek-Górecka, Ryszard Oliński, Jacek Budzyński
Introduction: Endothelial dysfunction is recognized as the earliest disorder in the development of atherosclerosis, in the pathogenesis of which oxidative stress plays a crucial role. The aim of this study was to determine the relationships between non-invasive parameters of vascular dysfunction and oxidative stress. Material and methods: Forty-eight individuals without clinical manifestation of atherosclerosis were studied. The plasma concentrations of the following were determined in all 48 subjects: retinol, ascorbic acid, α-tocopherol and uric acid, as well as the products of oxidative DNA damage repair: 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in blood leukocytes and urine, and 8-oxo-7,8-dihydroguanine (8-oxoGua) in urine...
2017: Archives of Medical Sciences. Atherosclerotic Diseases
https://www.readbyqxmd.com/read/29240587/reclaiming-autologous-amputated-tissue-for-limb-salvage-of-a-diabetic-foot-burn-with-underlying-critical-limb-ischemia
#4
Catherine N Tchanque-Fossuo, Andrew M Wishy, Kaitlyn I M West, David L Dawson, Sara E Dahle, John G Carson
BACKGROUND: Diabetes mellitus is a worldwide pandemic that impacts more than 387 million people, with 29 million individuals affected in the United States alone. Diabetic patients have a 25% lifetime risk of developing a diabetic foot ulcer (DFU). Having a DFU is associated with a risk of recurrence approaching 70%. In addition, 1 in 6 patients with DFU will have a lower-limb amputation, with an associated increase in mortality ranging from 47% to 70%. Therefore, limb salvage is critical in patients with DFU...
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29239331/ankle-brachial-index-and-brachial-ankle-pulse-wave-velocity-are-risk-factors-for-ischemic-stroke-in-patients-with-type-2-diabetes
#5
Ting Li, Xiu-Juan Wu, Xiao-Min Chen, Si-Bo Wang, Kang-Ding Liu, Ying-Qi Xing
The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity (BaPWV) and ankle-brachial index (ABI) are known to be associated with ischemic cardiovascular and cerebrovascular diseases, whether these measures predict the risk of ischemic cerebrovascular disease in diabetic patients remains unclear. 117 patients with type 2 diabetes were enrolled in this study. According to the results of head magnetic resonance imaging, the patients were divided into a diabetes-only group (n = 55) and a diabetes and ischemic stroke group (n = 62)...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29230568/ankle-brachial-pressure-index-as-a-predictor-of-the-2-year-outcome-after-transcatheter-aortic-valve-replacement-data-from-the-japanese-ocean-tavi-registry
#6
Masahiro Yamawaki, Motoharu Araki, Tsutomu Ito, Yosuke Honda, Takahiro Tokuda, Yoshiaki Ito, Hiroshi Ueno, Kazuki Mizutani, Minoru Tabata, Akihiro Higashimori, Norio Tada, Kensuke Takagi, Futoshi Yamanaka, Toru Naganuma, Yusuke Watanabe, Masanori Yamamoto, Shinichi Shirai, Kentaro Hayashida
Peripheral artery disease plays a pivotal role for access site selection in transcatheter aortic valve replacement (TAVR). Abnormal ankle-brachial index (ABI) is a generalized mortality marker in many cardiovascular scenarios. However, the long-term outcomes in high-risk TAVR populations remain unclear. We investigated the association between low ABI and 2-year outcome after TAVR. Of 1613 patients enrolled in the OCEAN-TAVI registry, 1458 (90.4%) who underwent ABI before TAVR were divided into groups: patients with (1) ABI ≥ 0...
December 11, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29230344/cystic-adventitial-disease-of-popliteal-artery-with-venous-aneurysm-of-popliteal-vein-two-year-follow-up-after-surgery
#7
Koki Takizawa, Hiroshi Osawa, Atsuo Kojima, Samuel J K Abraham, Shigeru Hosaka
We report a rare case of cystic adventitial disease of popliteal artery with venous aneurysm of popliteal vein. A 46-year-old woman had sudden-onset intermittent claudication and coldness in her right leg. The right-sided ankle-brachial pressure index (ABI) was 1.01, but peripheral arterial pulsation was decreased at knee venting position. Computed tomography revealed simple cystic lesion of the popliteal artery and stenosis of the arterial lumen in this lesion. The patient was treated by complete resection of the cystic adventitial layer of popliteal artery...
2017: Case Reports in Vascular Medicine
https://www.readbyqxmd.com/read/29227572/factors-associated-with-serum-magnesium-and-vascular-stiffness-in-maintenance-hemodialysis-patients
#8
Mai Yorifuji, Takahiro Kuragano, Sayuri Kawada, Wataru Fukao, Kazuhiro Toyoda, Takeshi Nakanishi
INTRODUCTION: We evaluated the associated factors of serum magnesium in patients on maintenance hemodialysis (MHD). Furthermore, we evaluated the relationship between low serum magnesium and arteriosclerosis in these patients. METHODS: In 129 patients on MHD, we evaluated the blood levels of magnesium, brachial-ankle pulse wave velocity (ba-PWV), ankle-brachial index (ABI), and intima-media thickness of the common carotid artery (IMT). FINDINGS: In MHD patients, the serum level of magnesium was significantly correlated with age, calcium, TNF-α, albumin, and ba-PWV but not with ABI or IMT...
December 11, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29225591/incidence-of-peripheral-arterial-disease-and-its-association-with-pulse-pressure-a-prospective-cohort-study
#9
Yong Mao, Yixiang Huang, Haining Yu, Peng Xu, Guangping Yu, Jinming Yu, Yiqiang Zhan
Background: The association of pulse pressure and peripheral arterial disease (PAD) has seldom been examined using a prospective design. This study aimed to investigate the association of pulse pressure with PAD incidence in an elderly general population. Methods: We utilized data from a cohort conducted in Beijing with additionally 2-year follow-up time. PAD was defined as an ankle brachial index value <0.9 in either leg. Cox proportional hazard regression model was used to quantify the magnitude of pulse pressure on PAD incidence...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29217446/the-use-of-the-profunda-femoral-artery-as-the-sole-target-vessel-to-bypass-aorto-iliac-disease-in-patients-with-critical-limb-ischemia-and-concomitant-unreconstructable-infra-inguinal-disease
#10
Nikolaos Kontopodis, Stella Lioudaki, Christos Chronis, Paris Kalogerakos, George Lazopoulos, Alexandra Papaioannou, Christos V Ioannou
BACKGROUND: Critical limb ischemia (CLI) often results from multilevel occlusive disease. There are occasions where a patent profunda femoral artery (PFA) is the only target artery that can be used as outflow during reconstruction to bypass aorto-iliac disease (AOID), with no further option for infra-inguinal revascularization. We aim to report results of the use of PFA as the sole target vessel for the treatment of these patients. METHODS: This is a retrospective, single-center study including CLI patients treated during 36-months...
December 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29202650/increasing-the-elective-endovascular-to-open-repair-ratio-of-popliteal-artery-aneurysm
#11
Axel Wrede, Frans Wiberg, Stefan Acosta
BACKGROUND: Open repair (OR) for popliteal artery aneurysm (PAA) has recently been challenged by endovascular repair (ER) as the primary choice of treatment. The aim of the present study was to evaluate time trends in treatment modality and compare outcomes between OR and ER among electively operated patients after start of screening in 2010 for abdominal aortic aneurysm (AAA), a disease highly associated with PAA. METHODS: Between January 1, 2009, and April 30, 2017, 102 procedures and 36 acute and 66 elective repairs for PAA were identified...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29198406/comparison-of-the-effect-of-aliskiren-versus-negative-controls-on-aortic-stiffness-in-patients-with-marfan-syndrome-under-treatment-with-atenolol
#12
Ji-Won Hwang, Eun Kyoung Kim, Shin Yi Jang, Tae-Young Chung, Chang-Seok Ki, Kiick Sung, Sung Mok Kim, Joonghyun Ahn, Keumhee Carriere, Yeon Hyeon Choe, Sung-A Chang, Duk-Kyung Kim
INTRODUCTION AND OBJECTIVES: The aim of this study was to evaluate the effect of aliskiren on aortic stiffness in patients with Marfan syndrome (MS). METHODS: Twenty-eight MS patients (mean age ± standard deviation: 32.6 ± 10.6 years) were recruited from November 2009 to October 2014. All patients were receiving atenolol as standard beta-blocker therapy. A prospective randomization process was performed to assign participants to either aliskiren treatment (150-300mg orally per day) or no aliskiren treatment (negative control) in an open-label design...
November 29, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29193492/perfusion-measures-for-symptom-severity-and-differential-outcome-of-revascularization-in-limb-ischemia-preliminary-results-with-arterial-spin-labeling-reactive-hyperemia
#13
Hou-Jen Chen, Trisha L Roy, Graham A Wright
BACKGROUND: Previously, a theoretical model based on microvascular physiology was established to facilitate the interpretation of calf perfusion dynamics recorded by arterial spin labeling (ASL). PURPOSE: To investigate the clinical relevance of novel perfusion indices by comparing them to the symptoms, response to revascularization, and short-term functional outcome in patients with peripheral arterial disease (PAD). STUDY TYPE: Prospective cohort study...
November 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29191431/epidemiological-characteristics-of-lower-extremity-arterial-disease-in-chinese-diabetes-patients-at-high-risk-a-prospective-multicenter-cross-sectional-study
#14
Xiaomei Zhang, Xingwu Ran, Zhangrong Xu, Zhifeng Cheng, Feixia Shen, Yanmei Yu, Lin Gao, Sanbo Chai, Changjiang Wang, Jianying Liu, Jing Liu, Zilin Sun, Jiajun Zhao, Linong Ji
AIMS: To determine the epidemiological characteristics of lower extremity arterial disease (LEAD) in high-risk patients and identify practical gaps in LEAD management. METHODS: This cross-sectional study consecutively enrolled 10681 patients with type 2 diabetes from 30 hospitals across China from June 2016 to January 2017. All patients were assessed for LEAD by the Ankle-Brachial Index in conjunction with lower limb ultrasonography according to local guidelines...
October 13, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29180796/sexual-dysfunction-as-a-determinant-of-cardiovascular-outcome-in-patients-undergoing-chronic-hemodialysis
#15
Vedran Premužić, Bojan Jelaković
Sexual dysfunction (SD) is common in men and women with chronic kidney disease (CKD) and is considered as an early marker for cardiovascular (CV) disease. We hypothesized that patients with SD have higher risk for vascular damage of the large arteries, accelerated vascular aging, and consequently higher CV mortality than other end-stage renal disease (ESRD) patients. In this study, the International Index of Erectile Function (IIEF) questionnaire and the Female Sexual Function Index (FSFI) questionnaire were applied in men and women, respectively...
November 27, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29180215/analysis-of-ischemic-muscle-in-patients-with-peripheral-artery-disease-using-x-ray-spectroscopy
#16
Ryan A Becker, Kim Cluff, Nithyanandhi Duraisamy, George P Casale, Iraklis I Pipinos
BACKGROUND: Peripheral artery disease (PAD) is a vascular disease caused by atherosclerosis, resulting in decreased blood flow to the lower extremities. The ankle-brachial index (ABI) is a standard PAD diagnostic test but only identifies reduced blood flow based on blood pressure differences. The early signs of PAD manifest themselves not only at a clinical level but also at an elemental and biochemical level. However, the biochemical and elemental alterations to PAD muscle are not well understood...
December 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29180182/perioperative-warming-oxygen-and-ilomedin-on-oxygenation-and-healing-in-infrainguinal-bypass-surgery
#17
Nathaniel Chiang, Odette A Rodda, Jamie Sleigh, Thodur Vasudevan
BACKGROUND: Perioperative adjuncts are utilized across surgical specialities with the goal of improving patient outcomes. High-dose oxygen and extended warming are shown to increase wound collagen deposition during abdominal surgery. Prostacyclin is shown to improve limb salvage and patency rate in infrainguinal bypass (IIB) surgery. This study evaluated the impact of these adjuncts on healing and perfusion post IIB surgery. METHODS: This randomized controlled study allocated patients undergoing IIB surgery into three treatment arms (perioperative high-dose oxygen, extended warming, and a synthetic prostacyclin) or a control group...
December 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29179693/unloading-shoes-for-intermittent-claudication-a-randomised-crossover-trial
#18
Garry A Tew, Ahmed Shalan, Alastair R Jordan, Liz Cook, Elizabeth S Coleman, Caroline Fairhurst, Catherine Hewitt, Stephen W Hutchins, Andrew Thompson
BACKGROUND: The purpose of this study was to assess the functional effects and acceptability of rocker-soled shoes that were designed to relatively "unload" the calf muscles during walking in people with calf claudication due to peripheral arterial disease. METHODS: In this randomised AB/BA crossover trial, participants completed two assessment visits up to two weeks apart. At each visit, participants completed walking tests whilst wearing the unloading shoes or visually-similar control shoes...
November 28, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29178183/predictors-of-an-abnormal-postexercise-ankle-brachial-index-importance-of-the-lowest-ankle-pressure-in-calculating-the-resting-ankle-brachial-index
#19
David W J Armstrong, Colleen Tobin, Murray F Matangi
BACKGROUND: The postexercise ankle-brachial index (ABI) is useful in patients with suspected peripheral arterial disease (PAD) and a normal resting ABI. Our objective was to determine the independent predictors of an abnormal postexercise ABI. HYPOTHESIS: We hypothesized that the lowest ankle systolic pressure to calculate the resting ABI would be associated with an abnormal post-exercise ABI. METHODS: Among 619 consecutive patients referred for suspected PAD, we calculated the postexercise ABI in patients with a normal resting ABI...
November 27, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29177410/relationship-of-acid-base-status-with-arterial-stiffness-in-community-living-elders-the-health-abc-study
#20
Wei Chen, Anne B Newman, Linda F Fried, Dena E Rifkin, Michael G Shlipak, Mark J Sarnak, Ronit Katz, Magdalena Madero, Kalani L Raphael, David A Bushinsky, Joachim H Ix
Background: Animal studies suggest that acidosis protects against arterial calcification, which contributes to arterial stiffness. The goal of this study was to investigate the associations of serum bicarbonate and pH with arterial stiffness in community-living older adults. Methods: We performed cross-sectional analyses among 1698 well-functioning participants 70-79 years of age. Bicarbonate and pH were measured by arterialized venous blood gas at the point of care...
November 21, 2017: Nephrology, Dialysis, Transplantation
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