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Martin Nettling, Nils Thieme, Andreas Both, Ivo Grosse
BACKGROUND: New technologies for analyzing biological samples, like next generation sequencing, are producing a growing amount of data together with quality scores. Moreover, software tools (e.g., for mapping sequence reads), calculating transcription factor binding probabilities, estimating epigenetic modification enriched regions or determining single nucleotide polymorphism increase this amount of position-specific DNA-related data even further. Hence, requesting data becomes challenging and expensive and is often implemented using specialised hardware...
2014: BMC Bioinformatics
Carolina Ayala, Gisela Erika Pennacchio, Marta Soaje, Norma Beatriz Carreño, Jakson Cioni Bittencourt, Graciela Alma Jahn, María Ester Celis, Susana Ruth Valdez
We previously showed that short-term hypo- and hyperthyroidism induce changes in neuropeptide glutamic-acid-isoleucine-amide (NEI) concentrations in discrete brain areas in male rats. To investigate the possible effects of hypo- and hyperthyroidism on NEI concentrations mainly in hypothalamic areas related to reproduction and behavior, female rats were sacrificed at different days of the estrous cycle. Circulating luteinizing hormone (LH), estradiol and progesterone concentrations were measured in control, hypothyroid (hypoT, treated with PTU during 7-9 days) and hyperthyroid (hyperT, l-T4 during 4-7 days) animals...
November 2013: Peptides
Samuel Brockington, Patricia Dos Santos, Beverley Glover, Louis Ronse De Craene
UNLABELLED:PREMISE OF THE STUDY: Caryophyllales are highly diverse in the structure of the perianth and androecium and show a mode of floral development unique in eudicots, reflecting the continuous interplay of gynoecium and perianth and their influence on position, number, and identity of the androecial whorls. The floral development of five species from four genera of a paraphyletic Molluginaceae (Limeum, Hypertelis, Glinus, Corbichonia), representing three distinct evolutionary lineages, was investigated to interpret the evolution of the androecium across Caryophyllales...
September 2013: American Journal of Botany
Constanza Matilde López-Fontana, Corina Verónica Sasso, María Eugenia Maselli, Flavia Eliana Santiano, Silvana Noemí Semino, Fernando Darío Cuello Carrión, Graciela Alma Jahn, Rubén Walter Carón
Epidemiological and in vitro data have not provided conclusive evidence concerning the involvement of thyroid hormones (THs) on mammary carcinogenesis. We used an in vivo model to assess the relationship between THs, adipose tissue and breast cancer development. Female Sprague‑Dawley rats were treated with a dose of 7,12-dimethylbenz(a)anthracene (15 mg/rat) at 55 days of age and were then divided into four experimental groups: hypothyroid rats (HypoT, 0.01% 6-N-propyl-2-thiouracil in drinking water), untreated control (EUT); hyperthyroid rats (HyperT, 0...
October 2013: Oncology Reports
Kristina Zivković, Ljiljana Marković-Denić, Vesna Bumbasirevi, Aleksandar R Lesić, Emilija Dubljanin-Raspopović, Marko Z Bumbasirević, Ljubomir M Djurasić
UNLABELLED: Osteoarthrosis is the most frequent joint disorder in the world. An increased incidence of total hip replacement (THR) and total knee replacement (TKR) has been noticed recently. AIM: To investigate demographic characteristics, comorbidities, surgical factors and postoperative complications of patients who received THR or TKR. MATERIAL AND METHOD: Patients aged at least 30 years hospitalized at the Clinics for Orthopaedic Surgery and Traumatology, Clinical Centre of Serbia, for THR or TKR between January 1, 2008 and January 1, 2010...
2011: Acta Chirurgica Iugoslavica
Georgios D Kitsios, Elias Zintzaras
BACKGROUND: The adrenergic receptor (adrenoceptor) family genes have been extensively studied as candidate genes in hypertension but the results of individual genetic association studies (GAS) are controversial and inconclusive. To clarify these data, a systematic assessment of GAS for adrenoceptor family genes in hypertension was conducted. METHODS: Data from 163 GAS involving 7 genes and 37 distinct genetic variants were analyzed and cataloged in CUMAGAS-HYPERT (Cumulative Meta-analysis of Genetic Association Studies-HYPERTension; a web-based information system, which allows the retrieval and synthesis of data from GAS in hypertension, available at http://biomath...
March 2010: American Journal of Hypertension
M M Al-Nozha, A K Osman
BACKGROUND: The results of the National Nutrition Survey of the people of the Kingdom of Saudi Arabia showed that the prevalence of arterial hypertension (BP >/= 160/95 mmHg) among the adult population is 5.3% and 7.3% for systolic and diastolic hypertension, respectively. The objective of this study, which is part of the Survey, was to investigate if the diversified ecological nature of the life of the people of the Kingdom has an effect on the prevalence of arterial hypertension in the adult population in the different geographical regions of the Kingdom...
1998: Annals of Saudi Medicine
Paolo Falaschi, Antonio Martocchia, Antonella Proietti, Rosaria D'Urso, Serena Gargano, Franco Culasso, Antonio Rocco
OBJECTIVE: To evaluate the hypothalamus-pituitary-thyroid (HPT) axis in patients with subclinical thyroid dysfunction recently reported to have either symptoms or organ involvements with potential morbidity, in order to better differentiate these patients with respect to controls. PATIENTS: Sixtythree patients with subclinical hyperthyroidism (HyperT), 178 normal subjects (EuT) and 106 patients with subclinical hypothyroidism (HypoT) were enrolled; the groups presented normal thyroid hormone (FT4, FT3) levels and, respectively, reduced (HyperT), normal (EuT) and increased (HypoT) TSH levels...
August 2004: Neuro Endocrinology Letters
Marc E A Spaanderman, Timo H A Ekhart, Peter W de Leeuw, Louis L H Peeters
BACKGROUND: In women prone to develop hypertensive complications, vascular reactivity fails to decrease in early pregnancy. Since hypertensive syndromes of pregnancy seem to be superimposed on a preexisting disorder, we tested the hypothesis that in formerly preeclamptic women, as compared to healthy parous controls, circulatory reactivity to angiotensin II is enhanced in the follicular phase of the menstrual cycle. METHODS: Sixty formerly preeclamptic women were subdivided into a hypertensive (HYPERT, n = 14), a normotensive thrombophilic (THROMB, n = 26), and a normotensive nonthrombophilic (ASYMPT, n = 20) subgroup...
September 2004: Journal of the Society for Gynecologic Investigation
M Spaanderman, T Ekhart, J van Eyck, P de Leeuw, L Peeters
BACKGROUND: The majority of women with a history of preeclampsia have either an underlying thrombophilic disorder or a vascular disorder. In this study, we tested the hypothesis that only the latter condition predisposes for abnormal hemodynamic adaptation to pregnancy. METHODS: Thirty-seven formerly preeclamptic subjects were subdivided into a hypertensive (HYPERT, N = 10), a normotensive thrombophilic (THROMB, N = 13) and a normotensive nonthrombophilic subgroup (NONTHROMB, N = 14)...
October 2001: Kidney International
D L Sparks
The premature presence of senile plaques (SP) in coronary artery disease (CAD), and neurofibrillary tangles (NFT) as well as SP in hypertension (HyperT), suggest a neuropathologic link between CAD, HyperT, and AD. Previous MI, CAD and HyperT often occur in and may increase the risk of AD. Expression of Apo-E4 likely increases risk of CAD by elevating blood cholesterol and the risk of AD via proposed interactions with beta-amyloid and/or free radicals (FRs). Any Apo-E4 effect is vague, but FRs probably mediate vascular damage in HyperT...
September 26, 1997: Annals of the New York Academy of Sciences
G H Gunasena, M F Kanz
Hyperthyroidism potentiates the in vivo hepatotoxicity of 1,1-dicholoroethylene (DCE) in rats, with a concomitant increase in [14C]-DCE covalent binding. The enhanced injury produced in hyperthyroid livers by DCE could be due to alterations in either the bioactivation or detoxication phases of DCE metabolism. Previous in vitro studies suggested that hyperthyroidism did not potentiate DCE hepatotoxicity by increasing DCE oxidation to intermediates which were able to covalently bind. Several factors, however, that could contribute to the magnitude of DCE bioactivation or covalent binding were not examined...
October 10, 1997: Journal of Toxicology and Environmental Health
S M De Lena, R F Echeverria, E Escudero, O A Gende, H E Cingolani
Blood pressure (BP) levels were measured in 450 students (mean age 20.8 +/- .11 years old) and were correlated with different parameters. Prevalence of arterial hypertension was, according to the JNC-V, 13% in males and 3% in females. The correlations between Body Mass Index (BMI) and BP levels were statistically significant either in males and females. Mean BP (MBP) increased 1.17 mmHg per unit of increase of BMI in males and 0.97 mmHg in females. According to the BP levels proposed by the JNC-V the male individuals were classified in three groups: optimal BP (OBP), high normal BP (HNBP) and hypertensives stage 1 (Hypert...
1996: Medicina
W R Bidlack
Nutrition and food science have each enhanced the development of an abundant, nutritious, safe food supply. A healthy diet should contain all of the required nutrients and sufficient calories to balance energy expenditure and provide for growth and maintenance throughout the life cycle. Importantly, dietary factors are associated with 5 of the 10 leading causes of death, including coronary heart disease, certain types of cancer, stroke, noninsulin dependent diabetes mellitus and atherosclerosis. National health care expenditures for 1990 totaled $666 billion of which 30% are related to inappropriate diet...
October 1996: Journal of the American College of Nutrition
D L Sparks, S W Scheff, H Liu, T Landers, F Danner, C M Coyne, J C Hunsaker
The apolipoprotein E genotype and cortical senile plaque (SP) and cortical and hippocampal neurofibrillary tangle (NFT) densities were determined in non-demented individuals and neuropathologically confirmed AD patients. The non-demented population was further subdivided according to presence or absence of pathologically established critical coronary artery disease (cCAD), hypertension (HyperT), or neither (non-heart disease; non-HD). The apolipoprotein E4 (APOE4) allele incidence and dose frequencies were increased in the AD, cCAD and HyperT groups compared to the non-HD controls...
June 1996: Journal of the Neurological Sciences
M F Kanz, L Kaphalia, S Mohsin, Z Taj, M T Moslen
Distribution, covalent binding, and biliary excretion of 1,1-dichloroethylene (DCE) were examined in euthyroid (EuT) and hyperthyroid (HyperT) rats, which are more vulnerable to DCE hepatotoxicity. Male Sprague-Dawley rats were made hyperthyroid by 3 sc injections of thyroxine at 48-h intervals prior to experiments; euthyroid controls received vehicle injections. A time course study monitored the circulation and excretion of 14C-DCE label for 24 h after administration of 14C-labeled DCE (50 mg/kg in mineral oil) in serial blood and urine samples...
February 1994: Journal of Toxicology and Environmental Health
D L Sparks, S W Scheff, H Liu, T M Landers, C M Coyne, J C Hunsaker
The incidence rates and numerical densities of argryophilic neurofibrillary tangles (NFT) and senile plaques (SP) were determined in non-demented individuals and subjects with Alzheimer's disease (AD). The non-AD subjects were grouped according to cardiac status; those individuals with critical coronary artery disease (cCAD), those hypertensive individuals without cCAD (HyperT), and those without heart disease (non-HD). The incidence and densities of SP and NFT were significantly greater in AD than any of the non-demented groups...
August 1995: Journal of the Neurological Sciences
H Kaciuba-Uscilko, G A Dudley, R L Terjung
The influence of thyroid status on the clearance of chylomicron 14C-labeled triglycerides (14C-TG), the fractional uptake of 14C-TG, and activity of lipoprotein lipase (LPL) in the different skeletal muscle fiber types was evaluated in pentobarbital-anesthetized rats. The turnover of plasma TG was approximately fourfold greater in the hyperthyroid (HyperT) compared to either euthyroid (EUT) or hypothyroid (HypoT) animals. The uptake of 14C-TG was increased in slow-twitch red and fast-twitch red muscle sections of the HyperT group and normal in the HypoT group...
June 1980: American Journal of Physiology
M Moser
The ambulatory management of hypertension is relatively simple. A key factor in the success of any program is motivation of both the physician and the patient. Workup should be limited to a few simple tests as outlined; need rarely, if ever, involve hospitalization; and can be completed in one or two office or clinic visits. Treatment of hypertion over a long-term period involves the use of specific drug therapy, although some slight modification of lifestyle or diet is occasionally helpful. There are numerous drugs available, and in over 80 to 85 percent of cases, an effective combination can be found...
1978: Cardiovascular Clinics
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