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Ampullary adenocarcinoma

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https://www.readbyqxmd.com/read/28731954/laparoscopic-pancreaticoduodenectomy-a-single-team-preliminary-experience
#1
Xiaohui Duan, Bo Jiang, Lixue Zhou, Jianhui Yang, Bingzhang Tian, Huiming Wen, Xianhai Mao
OBJECTIVE: The present study aimed to describe the authors' experience and the perioperative outcome for laparoscopic pancreaticoduodenectomy (LPD). MATERIALS AND METHODS: Perioperative clinical data of 57 consecutive pancreaticoduodenectomy (PD) procedures performed from January 2014 to May 2016 in the Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital were retrospectively analyzed. RESULTS: The median of operative time was 315 minutes (range, 220 to 575 min) and the median of intraoperative estimated blood loss was 200 mL (range, 100 to 550 mL)...
July 20, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28660333/paraduodenal-pancreatitis-benign-and-malignant-mimics-at-mri
#2
Pardeep K Mittal, Peter Harri, Sadhna Nandwana, Courtney C Moreno, Takashi Muraki, Volkan Adsay, Kelly Cox, Burcin Pehlivanoglu, Lauren F Alexander, Argha Chatterjee, Frank H Miller
Paraduodenal pancreatitis, also known as groove pancreatitis, is a rare form of chronic pancreatitis that masquerades as pancreatic adenocarcinoma affecting the pancreaticoduodenal groove, a potential space between the head of the pancreas, duodenum, and common bile duct. Two forms of groove pancreatitis have been described. The segmental form involves the pancreatic head with development of scar tissue within the groove, whereas the pure form affects the groove only, sparing the pancreatic head. Imaging findings of groove pancreatitis often overlap with primary duodenal, ampullary, or pancreatic neoplasms, which often results in a diagnostic challenge...
June 28, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28658766/clinicopathological-study-of-carcinoma-of-the-ampulla-of-vater-with-special-reference-to-muc1-muc2-and-muc5ac-expression
#3
Maithili Mandar Kulkarni, Siddhi Gaurish Sinai Khandeparkar, Avinash R Joshi, Aniket Kakade, Lokesh Fegade, Ketan Narkhede
INTRODUCTION: The ampulla of Vater consists of papilla, common channel, distal common bile duct and the distal main pancreatic duct. Ampullary carcinomas arise from two different types of mucosa, reflecting their broad histomorphological spectrum. Adenocarcinomas originating in the ampulla of Vater are classified as having either 'Intestinal' or 'Pancreatobiliary' type of differentiation. Pancreatobiliary type has consistently shown a worse prognosis. Various types of mucins are distributed in normal tissues and gastrointestinal tumours...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28648977/prognostic-relevance-of-lymph-node-status-for-patients-with-ampullary-adenocarcinoma-after-radical-resection-followed-by-adjuvant-treatment
#4
J Kwon, K Kim, E K Chie, B H Kim, J-Y Jang, S W Kim, D-Y Oh, Y-J Bang
PURPOSE: Attempts have been made to revise the nodal stage due to simplicity of current N staging system in ampullary adenocarcinoma. However, because of the disease rarity, there have only been a few studies assessing the prognostic impact of lymph node (LN) parameters. METHODS: We retrospectively analyzed 120 patients who underwent radical resection followed by adjuvant chemoradiotherapy for ampullary adenocarcinoma. The effect of LN parameters (number of total harvest LNs, number of metastatic LN (MLN), lymph node ratio (LNR), and log odds of positive LNs (LODDS)) on overall survival (OS), locoregional relapse-free survival (LRFS) and distant metastasis-free survival were evaluated...
June 15, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28633596/laparotomy-site-implantation-metastasis-of-carcinoma-of-the-papilla-of-vater
#5
Milan Radojkovic, Jasmina Gligorijevic, Miroslav Stojanovic, Goran Stanojevic, Ivan Ilic
Introduction Carcinomas of the papilla of Vater make up a heterogeneous group of tumours arising from different types of epithelium. Regional lymph nodes, liver and lungs are the primary sites of metastatic progression of these tumours. Case presentation We present a patient with an abdominal incision site metastasis of low-grade (mixed type) adenocarcinoma of the papilla of Vater one year after pylorus-preserving pancreaticoduodenectomy. Implantation metastasis of low-grade ampullary carcinoma in the laparotomy wound after open Whipple's procedure is unusual...
January 1, 2017: Scottish Medical Journal
https://www.readbyqxmd.com/read/28558658/therapeutic-outcomes-of-endoscopic-papillectomy-for-ampullary-neoplasms-retrospective-analysis-of-a-multicenter-study
#6
Sung Hoon Kang, Kook Hyun Kim, Tae Nyeun Kim, Min Kyu Jung, Chang Min Cho, Kwang Bum Cho, Ji Min Han, Ho Gak Kim, Hyun Soo Kim
BACKGROUND: Endoscopic papillectomy (EP) is reported to be a relatively safe and reliable procedure for complete resection of ampullary neoplasms. The aim of this study was to evaluate the therapeutic outcomes and complications of EP for ampullary neoplasms. METHODS: A retrospective multicenter study was conducted with 5 participating centers from January 2007 to July 2014. A total of 104 patients who underwent EP for ampullary neoplasms were reviewed retrospectively...
May 30, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28552015/ampullary-mixed-adenoneuroendocrine-carcinoma-surprise-histology-familiar-management
#7
Shyam Sunder Mahansaria, Nikhil Agrawal, Asit Arora, Chhagan Bihari, Murali Appukuttan, Tushar Kanti Chattopadhyay
INTRODUCTION: Mixed adenoneuroendocrine carcinoma (MANEC) has recently been defined by the World Health Organization in 2010. These are rare tumors and MANECs of ampullary region are even rarer. Only 19 cases have been reported in literature. We present 3 cases; the largest series, second case of amphicrine tumor and first case associated with chronic pancreatitis. METHODS: Retrospective review of 3 patients who were diagnosed to have ampullary MANEC. RESULTS: All 3 patients were diagnosed preoperatively as neuroendocrine carcinoma and underwent margin negative pancreaticoduodenectomy...
May 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28524160/stroma-regulated-hmga2-is-an-independent-prognostic-marker-in-pdac-and-aac
#8
Carina Strell, Karin Jessica Norberg, Artur Mezheyeuski, Jonas Schnittert, Praneeth R Kuninty, Carlos Fernández Moro, Janna Paulsson, Nicolai Aagaard Schultz, Dan Calatayud, Johannes Matthias Löhr, Oliver Frings, Caroline Sophie Verbeke, Rainer Lothar Heuchel, Jai Prakash, Julia Sidenius Johansen, Arne Östman
BACKGROUND: The HMGA2 protein has experimentally been linked to EMT and cancer stemness. Recent studies imply that tumour-stroma interactions regulate these features and thereby contribute to tumour aggressiveness. METHODS: We analysed 253 cases of pancreatic ductal adenocarcinoma (PDAC) and 155 cases of ampullary adenocarcinoma (AAC) for HMGA2 expression by IHC. The data were correlated with stroma abundance and supplemented by experimental studies. RESULTS: HMGA2 acts as an independent prognostic marker associated with a significantly shorter overall survival in both tumour types...
June 27, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28502094/pd-l1-overexpression-in-ampulla-of-vater-carcinoma-and-its-pre-invasive-lesions
#9
Deborah Saraggi, Francesca Galuppini, Andrea Remo, Emanuele D L Urso, Deborah Bacchin, Roberta Salmaso, Cristiano Lanza, Riccardo Q Bao, Giuseppe N Fanelli, Vincenza Guzzardo, Claudio Luchini, Marco Scarpa, Fabio Farinati, Matteo Fassan, Massimo Rugge
AIMS: PD-1/PD-L1 checkpoint immunotherapy has been proposed recently as a promising treatment in relapsed/refractory disease, used eventually in combination with traditional chemotherapy in different cancer settings. To date, no data are available concerning PD-L1 expression in ampulla of Vater carcinoma and its pre-invasive lesions. METHODS AND RESULTS: We assessed the immunohistochemical expression of PD-L1 in a series of 26 ampullary adenocarcinomas, 50 ampullary dysplastic lesions and 10 normal duodenal mucosa samples...
May 14, 2017: Histopathology
https://www.readbyqxmd.com/read/28467793/the-different-pathogeneses-of-sporadic-adenoma-and-adenocarcinoma-in-non-ampullary-lesions-of-the-proximal-and-distal-duodenum
#10
Ayumi Niwa, Seiya Kuwano, Hiroyuki Tomita, Keita Kimura, Yukiya Orihara, Tomohiro Kanayama, Kei Noguchi, Kenji Hisamatsu, Takayuki Nakashima, Yuichiro Hatano, Akihiro Hirata, Tatsuhiko Miyazaki, Kazuhiro Kaneko, Takuji Tanaka, Akira Hara
Non-ampullary duodenal adenoma with activation of Wnt/β-catenin signalling is common in familial adenomatous polyposis (FAP) patients, whereas sporadic non-ampullary adenoma is uncommon. The adenoma-carcinoma sequence similar to colon cancer is associated with duodenal tumors in FAP, but not always in sporadic tumors. We obtained 37 non-ampullary duodenal tumors, including 25 adenomas and 12 adenocarcinomas, were obtained from biopsies and endoscopic resections. We performed immunohistochemistry for β-catenin, the hallmark of Wnt activation, and aldehyde dehydrogenase 1 (ALDH1), a putative cancer stem cell marker...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28464575/-laparoscopic-pancreaticoduodenectomy-a-report-of-233-cases-by-a-single-team
#11
W W Jin, X W Xu, Y P Mou, Y C Zhou, R C Zhang, J F Yan, J Y Zhou, C J Huang, C Lu
Objective: To summary the experience of 233 cases of laparoscopic pancreaticoduodenectomy (LPD) performed by a single surgical team. Methods: Data of patients undergoing LPD from September 2012 to October 2016 were reviewed. There were 145 males and 88 females with the mean age of(60.3±13.0)years old, ranging from 19 to 92 years old, and the mean body mass index of (22.8±3.5)kg/m(2,) ranging from 16.3 to 36.8 kg/m(2). There were 195 patients with clinical manifestation and 54 patients who had the history of abdominal surgery...
May 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28417289/reporting-the-margin-in-pancreaticoduodenectomies-r0-versus-r1
#12
Chandralekha Shyamsunder Tampi, Somesh Nilkanth, Palepu Jagannath
AIM: This study was conducted to analyze the changes in margin positivity in pancreaticoduodenectomies, on using a standardized protocol, which bread loafs the pancreas and duodenum in the axial plane for adenocarcinomas arising in the pancreatic head, ampulla, terminal common bile duct (CBD), and duodenum, and then to assess whether these tumor subsets involve the margins in different ways. METHODS: The analysis was performed on 70 consecutive specimens, the pre-protocol specimens serving as the control group...
March 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28401006/genomic-and-proteomic-characterization-of-arid1a-chromatin-remodeller-in-ampullary-tumors
#13
Anca Nastase, Jin Yao Teo, Hong Lee Heng, Cedric Chuan Young Ng, Swe Swe Myint, Vikneswari Rajasegaran, Jia Liang Loh, Ser Yee Lee, London Lucien Ooi, Alexander Yaw Fui Chung, Pierce Kah Hoe Chow, Peng Chung Cheow, Wei Keat Wan, Rafy Azhar, Avery Khoo, Sam Xin Xiu, Syed Muhammad Fahmy Alkaff, Ioana Cutcutache, Jing Quan Lim, Choon Kiat Ong, Vlad Herlea, Simona Dima, Dan G Duda, Bin Tean Teh, Irinel Popescu, Tony Kiat Hon Lim
AT rich interactive domain 1A (ARID1A) is one of the most commonly mutated genes in a broad variety of tumors. The mechanisms that involve ARID1A in ampullary cancer progression remains elusive. Here, we evaluated the frequency of ARID1A and KRAS mutations in ampullary adenomas and adenocarcinomas and in duodenal adenocarcinomas from two cohorts of patients from Singapore and Romania, correlated with clinical and pathological tumor features, and assessed the functional role of ARID1A. In the ampullary adenocarcinomas, the frequency of KRAS and ARID1A mutations was 34...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28347353/two-synchronous-malignant-tumors-of-the-pancreas-a-case-report
#14
W S L De Silva, A A Pathirana, I Prematilleke, S A P D Rajapakse, P S H Hettiarachchi, D S Manawasinghe, B K Dassanayake
BACKGROUND: Only a limited number of multiple synchronous primary malignancies of the pancreas have been reported in the medical literature. We report a case of two solid malignant tumors of the pancreas diagnosed preoperatively. CASE PRESENTATION: We describe a 65-year-old Sri Lankan woman who presented with progressive obstructive jaundice. Initial contrast-enhanced computed tomography imaging detected a malignant tumor at the tail of her pancreas. A second tumor of the pancreatic head was detected with integrated imaging using multidetector computed tomography and multimodal magnetic resonance imaging...
March 28, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28314316/non-whipple-operations-in-the-management-of-benign-premalignant-and-early-cancerous-duodenal-lesions
#15
Alexandros Papalampros, Demetrios Moris, Athanasios Petrou, Nikolaos Dimitrokallis, Ioannis Karavokyros, Dimitrios Schizas, Ioanna Delladetsima, Theodore N Pappas, Evangelos Felekouras
AIM: We reviewed our 20-year experience with non-Whipple operations (pancreas-preserving duodenectomy and transduodenal ampullectomy) for the treatment of benign, premalignant or early-stage malignant duodenal lesions. PATIENTS AND METHODS: Twenty-four patients who underwent non-Whipple operations between January 1996 and December 2015 were identified from an institutional database and retrospectively analyzed. RESULTS: Between 1996 and 2015, 10 patients underwent pancreas-preserving duodenectomy and 14 patients underwent transduodenal ampullectomy...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28285709/management-and-outcomes-following-pancreaticoduodenectomy-for-ampullary-adenocarcinoma
#16
M T Chavez, J P Sharpe, T O'Brien, K T Patton, D C Portnoy, N A VanderWalde, J L Deneve, D Shibata, S W Behrman, P V Dickson
INTRODUCTION: The purpose of this study was to evaluate outcomes following pancreaticoduodenectomy(PD) for ampullary adenocarcinoma(AAC). METHODS: We evaluated patients having undergone PD for AAC and the impact of clinical/histopathologic factors and adjuvant therapy(AT) on survival. RESULTS: 52 patients underwent potentially curative PD. Perineural and lymphovascular invasion were associated with decreased survival. There was no difference in survival between patients treated with PD vs...
January 30, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28239461/tissue-microrna-profiles-as-diagnostic-and-prognostic-biomarkers-in-patients-with-resectable-pancreatic-ductal-adenocarcinoma-and-periampullary-cancers
#17
Dan Calatayud, Christian Dehlendorff, Mogens K Boisen, Jane Preuss Hasselby, Nicolai Aagaard Schultz, Jens Werner, Heike Immervoll, Anders Molven, Carsten Palnæs Hansen, Julia S Johansen
BACKGROUND: The aim of this study was to validate previously described diagnostic and prognostic microRNA expression profiles in tissue samples from patients with pancreatic cancer and other periampullary cancers. METHODS: Expression of 46 selected microRNAs was studied in formalin-fixed paraffin-embedded tissue from patients with resected pancreatic ductal adenocarcinoma (n = 165), ampullary cancer (n=59), duodenal cancer (n = 6), distal common bile duct cancer (n = 21), and gastric cancer (n = 20); chronic pancreatitis (n = 39); and normal pancreas (n = 35)...
2017: Biomarker Research
https://www.readbyqxmd.com/read/28214200/concurrent-met-copy-number-gain-and-kras-mutation-is-a-poor-prognostic-factor-in-pancreatobiliary-subtype-ampullary-cancers
#18
Mi Jung Kwon, Jeong Won Kim, Jang Yong Jeon, Eun Sook Nam, Seong Jin Cho, Hye-Rim Park, Soo Kee Min, Jinwon Seo, Kyueng-Whan Min, Ji-Young Choe, Hye Kyung Lee
Hepatocyte growth factor (HGF) and MET are candidates of targeted therapies for cancer patients. Although MET and HGF are commonly expressed in biliary tract cancers, their expression and gene copy number status and their association with KRAS mutations have not been investigated in pancreatobiliary-type ampullary adenocarcinomas (A-ACs), one of the aggressive periampullary cancers. MET and HGF expressions and MET copy number status were examined by performing immunohistochemistry (IHC) and silver in situ hybridization (SISH) in 62 surgically resected, paraffin-embedded tumors, respectively...
January 11, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28211946/extra-ampullary-duodenal-adenoma-a-clinicopathological-study
#19
Kazunori Hijikata, Tetsuo Nemoto, Yoshinori Igarashi, Kazutoshi Shibuya
AIMS: Extra-ampullary duodenal adenoma (EADA) is a rare condition with poorly described clinicopathological details. In this study, we aimed to characterize EADA clinicopathologically. METHODS AND RESULTS: We performed a retrospective review of 44 serial cases of EADA. Each EADA was categorized as either gastric-type (n = 5) or intestinal-type (n = 39). All gastric-type adenomas were located in the first portion of the duodenum and exhibited a pedunculated shape...
February 17, 2017: Histopathology
https://www.readbyqxmd.com/read/28162214/-the-role-of-hong-s-single-stitch-duct-to-mucosa-pancreaticojejunostomy-in-laparoscopic-pancreaticoduodenectomy
#20
D F Hong, Y H Liu, Y H Zhang, Y C Wang, Z M Wang, W D Wu, G L Shen, J G Zhang, W Zhang, J Cheng, S Y Peng
Objective: To investigate the role of "Hong's single-stitch duct to mucosa pancreaticojejunostomy(HSDMP)" in laparoscopic pancreaticoduodenectomy (LPD). Methods: The clinical data including perioperative and short-term outcomes of 51 cases of LPD with HSDMP which performed in Zhejiang Provincial People's Hospital(33 cases) and Frist Clinical Hospital of Jilin University(18 cases) between April and October 2016 were reviewed retrospectively. There were 31 male patients and 20 female patients. The mean age was(59±11)years...
February 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
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