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https://www.readbyqxmd.com/read/29664423/long-term-follow-up-of-antithrombotic-management-patterns-in-acute-coronary-syndrome-patients
#1
Fatih Sinan Ertaş, Lale Tokgozoglu
OBJECTIVE: The aim of this study was to evaluate the longterm, post-discharge follow-up of antithrombotic management patterns (AMPs), clinical outcomes, and real-life health status of patients hospitalized acute coronary syndrome (ACS). METHODS: A total of 1034 patients hospitalized for ACS within 24 hours of symptom onset who survived to discharge were included. Of those, 514 had ST-segment elevation myocardial infarction (STEMI) and 520 had unstable angina (UA)/non-STEMI (NSTEMI)...
April 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29626151/metabolomic-profiling-in-acute-st-segment-elevation-myocardial-infarction-identifies-succinate-as-an-early-marker-of-human-ischemia-reperfusion-injury
#2
Matthias Kohlhauer, Sam Dawkins, Ana S H Costa, Regent Lee, Timothy Young, Victoria R Pell, Robin P Choudhury, Adrian P Banning, Rajesh K Kharbanda, Kourosh Saeb-Parsy, Michael P Murphy, Christian Frezza, Thomas Krieg, Keith M Channon
BACKGROUND: Ischemia-reperfusion injury following ST-segment-elevation myocardial infarction (STEMI) is a leading determinant of clinical outcome. In experimental models of myocardial ischemia, succinate accumulation leading to mitochondrial dysfunction is a major cause of ischemia-reperfusion injury; however, the potential importance and specificity of myocardial succinate accumulation in human STEMI is unknown. We sought to identify the metabolites released from the heart in patients undergoing primary percutaneous coronary intervention for emergency treatment of STEMI...
April 6, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29624086/does-acute-myocardial-infarction-kill-more-people-on-weekends-analysis-of-in-hospital-mortality-rates-for-weekend-admissions-in-portugal
#3
Francesca Fiorentino, Raquel Ascenção, Nicoletta Rosati
Objectives To investigate a possible weekend effect in the in-hospital mortality rate for acute myocardial infarction in Portugal, and whether the delay in invasive intervention contributes to this effect. Methods Data from the National 2011-2015 Diagnostic-Related-Group databases were analysed. The focus was on adult patients admitted via the emergency department and with the primary diagnosis of acute myocardial infarction. Patients were grouped according to ST-elevation myocardial infarction and non-ST-elevation myocardial infarction episodes...
January 1, 2018: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/29621983/single-and-dual-antiplatelet-therapy-in-elderly-patients-of-medically-managed-myocardial-infarction
#4
Ting-Tse Lin, Hsiu-Yun Lai, K Arnold Chan, Yen-Yun Yang, Chao-Lun Lai, Mei-Shu Lai
BACKGROUNDS: To examine the comparative effectiveness between dual and single antiplatelet therapies in real-world, medically managed elderly patients with acute myocardial infarction (AMI). METHODS: This retrospective study identified very elderly (> 85 years) patients, who were medically managed, with their first AMI from the Taiwan National Health Insurance claims database from 2007 to 2010. Patients were classified as dual antiplatelet therapy (DAPT) group, aspirin only group and clopidogrel only group...
April 5, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29550105/high-grade-atrioventricular-block-in-patients-with-acute-myocardial-infarction-insights-from-a-contemporary-multi-center-survey
#5
Hilmi Alnsasra, Binyamin Ben-Avraham, Shmuel Gottlieb, Merav Ben-Avraham, Ran Kronowski, Zaza Iakobishvili, Ilan Goldenberg, Boris Strasberg, Moti Haim
High-grade atrioventricular block (HAVB) is a frequent complication of acute myocardial infarction (AMI) and is associated with increased morbidity and mortality. We aimed to evaluate the incidence, predictors, and prognostic significance of HAVB in a contemporary cohort of patients with AMI, in the recent era of early reperfusion. Patients with acute coronary syndromes (n=11,487) during the years 2000-2010 were included. Patients were divided into two groups: with HAVB (n=308, 2.7%) and without HAVB (n=11,179, 97...
March 7, 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29543035/guideline-adherence-regarding-critical-time-intervals-in-the-german-chest-pain-unit-registry
#6
Mehrshad Vafaie, Matthias Hochadel, Thomas Münzel, Birgit Hailer, Burghard Schumacher, Gerd Heusch, Thomas Voigtländer, Harald Mudra, Michael Haude, Sebastian Barth, Claus Schmitt, Harald Darius, Lars S Maier, Hugo A Katus, Jochen Senges, Evangelos Giannitsis
BACKGROUND: Since 2008, the German Cardiac Society certified 256 Chest Pain Units (CPUs). Little is known about adherence to recommended performance measures in patients with suspected acute coronary syndrome (ACS) presenting to CPUs. We investigated guideline-adherence regarding critical time intervals and selected performance measures in German Chest Pain Units. METHODS: From 2008 to 2014, 23,804 consecutive patients with suspected ACS were prospectively enrolled in the Chest Pain Unit registry of the German Cardiac Society...
March 1, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29541260/risk-stratification-and-in-hospital-morality-in-patients-presenting-with-acute-coronary-syndrome-acs-in-bahrain
#7
Taysir S Garadah, Khalid Bin Thani, Leena Sulibech, Ahmed A Jaradat, Mohamed E Al Alawi, Haytham Amin
Background: Risk factors and short-term mortality in patients presented with Acute Coronary Syndrome (ACS) in Bahrain has not been evaluated before. Aim: In this prospective observational study, we aim to determine the clinical risk profiles of patients with ACS in Bahrain and describe the incidence, pattern of presentation and predictors of in-hospital clinical outcomes after admission. Methods: Patients with ACS were prospectively enrolled over a 12 month period...
2018: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/29535227/effectiveness-of-new-antiplatelets-in-the-prevention-of-recurrent-myocardial-infarction
#8
Lamiae Grimaldi-Bensouda, Nicolas Danchin, Jean Dallongeville, Bruno Falissard, Alain Furber, Yves Cottin, Laurent Bonello, Olivier Morel, Florence Leclercq, Etienne Puymirat, Fahmi Ghanem, Nicolas Delarche, Jacques Benichou, Lucien Abenhaim
OBJECTIVE: To compare ticagrelor and prasugrel with clopidogrel for recurrent fatal and non-fatal myocardial infarction (reMI) in real-life conditions. METHODS: Case-referent study using the Pharmacoepidemiological General Research eXtension (PGRx)-acute coronary syndrome (ACS) registry. Cases were patients with reMI from a cohort with index ACS or external to the cohort (same sites). Referents from the cohort, without recurrent event, were matched on index ACS type and date, age and sex with reMI cases...
March 13, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29527858/ethnicity-of-symptomatic-coronary-artery-disease-referred-for-coronary-angiography-in-the-galilee-prevalence-risk-factors-and-a-case-for-screening-and-modification
#9
Nizar Andria, Ali Nassar, Fabio Kusniec, Diab Ghanim, Dahud Qarawani, Erez Kachel, Khaled Taha, Offer Amir, Shemy Carasso
BACKGROUND: Coronary artery disease (CAD) has known risk factors. Individual risks related to specific ethnicities are complex and depend on genetic predisposition and lifestyle. OBJECTIVES: To compare the nature and prevalence of risk factors in Arab and non-Arab ethnic patients with symptomatic obstructive CAD referred for coronary angiography. METHODS: CAD, defined as coronary angiography with a ≥ 50% narrowing in ≥ 1 vessel, was diagnosed in 1029 patients admitted to a medical center between April 2014 and October 2015...
March 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29498538/weekend-effect-in-acute-coronary-syndrome-a-meta-analysis-of-observational-studies
#10
Chun Shing Kwok, Mohammed Al-Dokheal, Sami Aldaham, Claire Rushton, Rob Butler, Tim Kinnaird, Azfar Zaman, M Justin Zaman, Adam Timmis, Mamas A Mamas
BACKGROUND: The effect of a weekend compared with a weekday hospital admission on patient outcomes after an acute coronary syndrome is unclear. This study aims to determine whether collectively there is a weekend effect in acute coronary syndrome. METHOD: We conducted a systematic review and meta-analysis of cohort studies examining the association between weekend compared to weekday admission at any time of the day and early mortality (in-hospital or 30-day). A search was performed on Medline and Embase and relevant studies were pooled using random effects meta-analysis for risk of early mortality...
March 1, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29429635/clinical-findings-after-bioresorbable-vascular-scaffold-implantation-in-an-unrestricted-cohort-of-patients-with-st-segment-elevation-myocardial-infarction-from-the-rai-registry
#11
Elisabetta Moscarella, Alfonso Ielasi, Attilio Varricchio, Maria Carmen De Angelis, Bruno Loi, Giuseppe Tarantini, Paolo Calabrò, Bernardo Cortese, Pietro Mazzarotto, Gabriele Gabrielli, Francesco Pisano, Michela Facchin, Leonardo Misuraca, Valerio Lucci, Roberto Gistri, Gabriele Tumminello, Luciano Moretti, Alessandro Colombo, Alessandro Durante, Massimo Fineschi, Davide Piraino, Maurizio Ferrario, Sebastian Coscarelli, Annamaria Nicolino, Maurizio Tespili, Donatella Corrado, Giuseppe Steffenino
BACKGROUND: The bioresorbable vascular scaffold (BVS) technology may be an appealing option in ST-segment elevation myocardial infarction (STEMI) patients. However, the available evidence on its use in this challenging subset is limited. METHODS: Registro Absorb Italiano (RAI) is a multicenter, prospective registry that aims to assess BVS performance through a 5-year follow-up of all consecutive patients who undergone at least 1 successful BVS implantation. As a part of it, a subgroup analysis in STEMI patients was performed and the outcomes of this cohort compared to the remaining population (defined as "non-STEMI") are reported here...
February 3, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29421988/high-density-lipoprotein-cholesterol-hdl-c-levels-independently-correlates-with-cardiac-arrhythmias-and-atrial-fibrillation
#12
Farzin Brian Boudi, Nicholas Kalayeh, Mohammad Reza Movahed
OBJECTIVE: Acute coronary syndrome is frequently complicated by rhythm disturbances, yet any association between high-density lipoprotein (HDL) cholesterol levels and arrhythmias in the setting of non-ST-segment elevation myocardial infarction (non-STEMI) is uncertain. The goal of this study was to evaluate any association between HDL-cholesterol levels and arrhythmias in the setting of non-STEMI. METHODS: Retrospective data from Phoenix Veterans Affair Medical Center records were utilized for our study...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29381922/immediate-versus-deferred-stenting-for-patients-undergoing-primary-or-emergent-percutaneous-coronary-intervention-protocol-for-a-systematic-review-and-meta-analysis
#13
REVIEW
Yong Liu, Sheikh Mohammed Shariful Islam, Clara K Chow, Shiqun Chen, Muhammad Umer Siddiqui, Qiang Li, Kai-Yang Lin, Kun Wang, Guoli Sun, Ying-Ling Zhou, Jiyan Chen, David Brieger
INTRODUCTION: Primary or emergent percutaneous coronary intervention (PCI) with stenting is the standard treatment for patients with ST-segment elevation myocardial infarction (STEMI) or non-STEMI acute coronary syndromes (ACS) at high risk. The value of delayed stenting following balloon-facilitated reperfusion in these patients is largely unknown. METHODS AND ANALYSIS: This systematic review aims to assess whether delayed stenting (vs immediate stenting) improves angiographic and cardiovascular clinical outcomes for patients with STEMI or non-STEMI ACS undergoing primary or emergent PCI...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29361353/area-at-risk-and-collateral-circulation-in-a-first-acute-myocardial-infarction-with-occluded-culprit-artery-stemi-vs-non-stemi-patients
#14
Jaume Figueras, Imanol Otaegui, Gerard Marti, Enric Domingo, Jordi Bañeras, José A Barrabés, Bruno Garcia Del Blanco, David Garcia-Dorado
BACKGROUND: It is unclear why among patients with first acute myocardial infarction and an occluded culprit artery only some present ST segment elevation. In fact, there is no study that compares the angiographic area at risk and the collateral circulation in first NSTEMI vs STEMI patients. METHODS AND RESULTS: 205 patients admitted for myocardial infarction with occluded culprit artery were included, 132 STEMI and 73 NSTEMI. Demographic data, the area at risk determined by the BARI score and collateral supply by the Rentrop score from the 2 groups were compared...
May 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29298651/is-atherothromboaspiration-a-possible-solution-for-the-prevention-of-no-reflow-phenomenon-in-acute-coronary-syndromes-single-centre-experience-and-review-of-the-literature
#15
Antonis S Manolis
BACKGROUND: Intracoronary thrombus in acute myocardial infarction (MI) confers higher rates of no-reflow with attendant adverse consequences. Earlier randomized-controlled-trials (RCTs) of routine thromboaspiration during percutaneous coronary intervention (PCI) indicated a clinical benefit, but more recent RCTs were negative. However, data of selective use of this adjunctive approach remain scarce. OBJECTIVE: The aim of this single-centre prospective study was to report the results of selective thromboaspiration during PCI in patients with intracoronary thrombi, and also to provide an extensive literature review on current status of thromboaspiration...
January 1, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29259501/left-circumflex-coronary-artery-as-the-culprit-vessel-in-st-segment-elevation-myocardial-infarction
#16
Diab Ghanim, Fabio Kusniec, Wadi Kinany, Dahud Qarawani, David Meerkin, Khaled Taha, Offer Amir, Shemy Carasso
The prevalence of the left circumflex coronary artery (LCx) as the culprit vessel in ST-segment-elevation myocardial infarction (STEMI) is reportedly lowest among that of the 3 main epicardial arteries, and has not been described for non-STEMI (NSTEMI) and stable angina pectoris. We sought to define the distribution of culprit arteries in these clinical presentations and suggest mechanisms for the differences. We reviewed 189 coronary angiograms of patients with STEMI, 203 with NSTEMI, and 548 with stable angina (n=940), and compared distributions of stenotic and culprit coronary arteries (lesions prompting intervention)...
October 2017: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/29242184/sex-differences-in-treatments-relative-survival-and-excess-mortality-following-acute-myocardial-infarction-national-cohort-study-using-the-swedeheart-registry
#17
Oras A Alabas, Chris P Gale, Marlous Hall, Mark J Rutherford, Karolina Szummer, Sofia Sederholm Lawesson, Joakim Alfredsson, Bertil Lindahl, Tomas Jernberg
BACKGROUND: This study assessed sex differences in treatments, all-cause mortality, relative survival, and excess mortality following acute myocardial infarction. METHODS AND RESULTS: A population-based cohort of all hospitals providing acute myocardial infarction care in Sweden (SWEDEHEART [Swedish Web System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies]) from 2003 to 2013 was included in the analysis...
December 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29240961/anomalous-origin-of-culprit-coronary-arteries-in-acute-coronary-syndromes
#18
Paweł Tyczyński, Krzysztof Kukuła, Arkadiusz Pietrasik, Tomasz Bochenek, Artur Dębski, Anna Oleksiak, Miłosz Marona, Michał Lelek, Janina Stępińska, Adam Witkowski
BACKGROUND: To describe a series of acute coronary syndrome (ACS) patients in whom anomalous origin of culprit coronary artery (AOCCA) was diagnosed. Percutaneous coronary interventions (PCI) in AOCCA are performed very infrequently. METHODS: Electronic databases from three high-volume tertiary cardiac centers were retrospectively searched for the presence of AOCCA in ACS. RESULTS: Different types of AOCCA in ACS were identified in 20 patients...
December 14, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29199084/ethnicity-influences-cardiovascular-outcomes-and-complications-in-patients-with-type-2-diabetes
#19
S Kou, J Y Cao, S Yeo, D J Holmes-Walker, S L Lau, J E Gunton
AIM: To determine whether cardiovascular outcomes in type 2 diabetes (T2D) differ according to ethnicity, and whether ethnicity influences the effect of gender on these outcomes in Caucasians, East-Southeast-Asians, Middle-Easterners, South-Asians and Pacific-Islanders. METHODS: We compared demographics, HbA1c, lipid profile, renal function markers, and prevalence of macrovascular and microvascular complications between ethnic groups. Cross-sectional data was prospectively collected from 204 consecutive patients at Westmead Hospital's T2D clinic from April-October 2015...
February 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29177059/gender-differences-in-the-decrease-of-in-hospital-mortality-in-patients-with-acute-myocardial-infarction-during-the-last-20-years-in-switzerland
#20
Dragana Radovanovic, Burkhardt Seifert, Marco Roffi, Philip Urban, Hans Rickli, Giovanni Pedrazzini, Paul Erne
Objective: To assess temporal trends of in-hospital mortality in patients with acute myocardial infarction (AMI) enrolled in the Swiss nationwide registry (AMIS Plus) over the last 20 years with regard to gender, age and in-hospital treatment. Methods: All patients with AMI from 1997 to 2016 were stratified according to ST-segment elevation myocardial infarction (STEMI) or non-STEMI (NSTEMI), and gender using logistic regression analyses. Results: Among 51 725 patients, 30 398 (59%) had STEMI and 21 327 (41%) had NSTEMI; 73% were men (63...
2017: Open Heart
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