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https://www.readbyqxmd.com/read/28644906/cholinesterases-in-normal-and-alzheimer-s-disease-primary-olfactory-gyrus
#1
Hayam Hamodat, Meghan K Cash, John D Fisk, Sultan Darvesh
AIMS: Alzheimer's disease (AD) is characterized by cholinergic dysfunction and deposition of β-amyloid (Aβ) plaques and tau neurofibrillary tangles (NFTs) in the brain. Olfactory abnormalities often precede cognitive symptoms in AD, indicating early involvement of pathology in olfactory structures. The cholinergic system is important not only in cognition but also in modulation of the olfactory system. The primary olfactory gyrus (POG) is comprised of the olfactory tract, anterior olfactory nucleus (AON) and olfactory area (OA)...
June 23, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28625855/children-s-purchase-behavior-in-the-snack-market-can-branding-or-lower-prices-motivate-healthier-choices
#2
Monika Hartmann, Sean B Cash, Ching-Hua Yeh, Stefanie C Landwehr, Anna R McAlister
BACKGROUND: Children's dietary-related diseases and their associated costs have expanded dramatically in many countries, making children's food choice a policy issue of increasing relevance. As children spend a considerable amount of money on energy-dense, nutrient-poor (EDNP) products, a better understanding of the main drivers of children's independent food purchase decisions is crucial to move this behavior toward healthier options. OBJECTIVE: The objective of the study is to investigate the role of branding and price in motivating children to choose healthier snack options...
June 15, 2017: Appetite
https://www.readbyqxmd.com/read/28566529/unconditional-seasonal-cash-transfer-increases-intake-of-high-nutritional-value-foods-in-young-burkinabe-children-results-of-24-hour-dietary-recall-surveys-within-the-mam-out-randomized-controlled-trial
#3
Audrey Tonguet-Papucci, Freddy Houngbe, Lieven Huybregts, Myriam Ait-Aissa, Chiara Altare, Patrick Kolsteren, Jean-François Huneau
Background: Cash transfer programs have the potential to improve dietary intake by improving accessibility to food. However, quantitative data on the impact of cash transfer programs on children's energy and nutrient intakes are lacking.Objective: The aim of this study was to evaluate the effect of seasonal unconditional cash transfers on children's energy, micro- and macronutrient, and food group intakes during the lean season in Burkina Faso.Methods: Within the framework of the MAM'Out (Moderate Acute Malnutrition Out) cluster-randomized controlled trial, two 24-h dietary recall surveys were conducted in July and August 2014...
May 31, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28551540/bisphenol-a-alternatives-in-thermal-paper-from-the-netherlands-spain-sweden-and-norway-screening-and-potential-toxicity
#4
Maria K Björnsdotter, Willem Jonker, Jessica Legradi, Jeroen Kool, Ana Ballesteros-Gómez
Thermal paper contains potentially toxic additives, such as bisphenol A (BPA), as a common color developer. Because of its known endocrine disrupting effects, structural analogues to BPA, such as bisphenol S (BPS), D-8 and Pergafast 201, have been used as alternatives, but little is known about the presence and toxicological effects of alternatives other than BPS. In this study, thermal paper is screened by direct probe ambient mass spectrometry (rapid pre-screening method not requiring sample preparation) and by liquid chromatography (LC) with high resolution time-of flight (TOF-MS) mass spectrometry...
May 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28542506/impact-evaluation-of-different-cash-based-intervention-modalities-on-child-and-maternal-nutritional-status-in-sindh-province-pakistan-at-6-mo-and-at-1-y-a-cluster-randomised-controlled-trial
#5
RANDOMIZED CONTROLLED TRIAL
Bridget Fenn, Tim Colbourn, Carmel Dolan, Silke Pietzsch, Murtaza Sangrasi, Jeremy Shoham
BACKGROUND: Cash-based interventions (CBIs), offer an interesting opportunity to prevent increases in wasting in humanitarian aid settings. However, questions remain as to the impact of CBIs on nutritional status and, therefore, how to incorporate them into emergency programmes to maximise their success in terms of improved nutritional outcomes. This study evaluated the effects of three different CBI modalities on nutritional outcomes in children under 5 y of age at 6 mo and at 1 y. METHODS AND FINDINGS: We conducted a four-arm parallel longitudinal cluster randomised controlled trial in 114 villages in Dadu District, Pakistan...
May 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28529873/white-matter-hyperintensities-are-seen-only-in-grn-mutation-carriers-in-the-genfi-cohort
#6
Carole H Sudre, Martina Bocchetta, David Cash, David L Thomas, Ione Woollacott, Katrina M Dick, John van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James B Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni Frisoni, Robert Laforce, Elizabeth Finger, Alexandre de Mendonça, Sandro Sorbi, Sébastien Ourselin, M Jorge Cardoso, Jonathan D Rohrer
Genetic frontotemporal dementia is most commonly caused by mutations in the progranulin (GRN), microtubule-associated protein tau (MAPT) and chromosome 9 open reading frame 72 (C9orf72) genes. Previous small studies have reported the presence of cerebral white matter hyperintensities (WMH) in genetic FTD but this has not been systematically studied across the different mutations. In this study WMH were assessed in 180 participants from the Genetic FTD Initiative (GENFI) with 3D T1- and T2-weighed magnetic resonance images: 43 symptomatic (7 GRN, 13 MAPT and 23 C9orf72), 61 presymptomatic mutation carriers (25 GRN, 8 MAPT and 28 C9orf72) and 76 mutation negative non-carrier family members...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28506682/colorectal-cancer-inflammatory-bowel-disease-nexus-and-felony-of-escherichia-coli
#7
REVIEW
Abdul Arif Khan, Zakir Khan, Abdul Malik, Mohd Abul Kalam, Phillip Cash, Mohd Tashfeen Ashraf, Aws Alshamsan
Colorectal cancer (CRC) has a multifactorial etiology. Although the exact cause of CRC is still elusive, recent studies have indicated microbial involvement in its etiology. Escherichia coli has emerged as an important factor in CRC development since the bacterium can cause changes in the gut that lead to cancerous transformation. A number of studies indicate that chronic inflammation induced by microorganisms, including E. coli, during inflammatory bowel disease (IBD) predisposes an individual to CRC. The evidence that support the role of E...
July 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/28506226/institutional-delivery-service-utilization-and-associated-factors-among-women-of-reproductive-age-in-the-mobile-pastoral-community-of-the-liban-district-in-guji-zone-oromia-southern-ethiopia-a-cross-sectional-study
#8
Wako Golicha Wako, Dejene Hailu Kassa
BACKGROUND: Globally, an estimated 289,000 maternal deaths occurred in 2013. Majority of these deaths occurred in sub-Saharan Africa and Southern Asia. Mobility of pastoralists is a well-recognized survival strategy in arid and semi-arid land of sub-Saharan Africa. However governments often encourage settlement as a solution to the difficulty of providing health services for mobile pastoralists. This study aimed to assess utilization of institutional delivery and associated factors among women of reproductive age in the mobile pastoral community of the Liban District in Guji zone, Oromia, Ethiopia...
May 15, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28499423/could-cash-and-good-parenting-affect-child-cognitive-development-a-cross-sectional-study-in-south-africa-and-malawi
#9
Lorraine Sherr, Ana Macedo, Mark Tomlinson, Sarah Skeen, Lucie Dale Cluver
BACKGROUND: Social protection interventions, including cash grants and care provision have been shown to effectively reduce some negative impacts of the HIV epidemic on adolescents and families. Less is known about the role of social protection on younger HIV affected populations. This study explored the impact of cash grants on children's cognitive development. Additionally, we examined whether combined cash and care (operationalised as good parenting) was associated with improved cognitive outcomes...
May 12, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28480617/comparison-of-arterial-spin-labeling-registration-strategies-in-the-multi-center-genetic-frontotemporal-dementia-initiative-genfi
#10
Henri J M M Mutsaerts, Jan Petr, David L Thomas, Enrico de Vita, David M Cash, Matthias J P van Osch, Xavier Golay, Paul F C Groot, Sebastien Ourselin, John van Swieten, Robert Laforce, Fabrizio Tagliavini, Barbara Borroni, Daniela Galimberti, James B Rowe, Caroline Graff, Francesca B Pizzini, Elizabeth Finger, Sandro Sorbi, Miguel Castelo Branco, Jonathan D Rohrer, Mario Masellis, Bradley J MacIntosh
PURPOSE: To compare registration strategies to align arterial spin labeling (ASL) with 3D T1-weighted (T1w) images, with the goal of reducing the between-subject variability of cerebral blood flow (CBF) images. MATERIALS AND METHODS: Multi-center 3T ASL data were collected at eight sites with four different sequences in the multi-center GENetic Frontotemporal dementia Initiative (GENFI) study. In a total of 48 healthy controls, we compared the following image registration options: (I) which images to use for registration (perfusion-weighted images [PWI] to the segmented gray matter (GM) probability map (pGM) (CBF-pGM) or M0 to T1w (M0-T1w); (II) which transformation to use (rigid-body or non-rigid); and (III) whether to mask or not (no masking, M0-based FMRIB software library Brain Extraction Tool [BET] masking)...
May 8, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28467193/a-global-comprehensive-review-of-economic-interventions-to-prevent-intimate-partner-violence-and-hiv-risk-behaviours
#11
Andrew Gibbs, Jessica Jacobson, Alice Kerr Wilson
BACKGROUND: Intimate partner violence (IPV) and HIV are co-occurring global epidemics, with similar root causes of gender and economic inequalities. Economic interventions have become a central approach to preventing IPV and HIV. OBJECTIVE/METHODS: We undertook a comprehensive scoping review of published evaluations of economic interventions that sought to prevent IPV and/or HIV risk behaviours. RESULTS: Forty-five separate analyses of interventions met our criteria...
January 2017: Global Health Action
https://www.readbyqxmd.com/read/28452692/a-cash-back-rebate-program-for-healthy-food-purchases-in-south-africa-selection-and-program-effects-in-self-reported-diet-patterns
#12
Ruopeng An, Roland Sturm
OBJECTIVES: A South African insurer launched a rebate program for healthy food purchases for its members, but only available in program-designated supermarkets. To eliminate selection bias in program enrollment, we estimated the impact of subsidies in nudging the population towards a healthier diet using an instrumental variable approach. METHODS: Data came from a health behavior questionnaire administered among members in the health promotion program. Individual and supermarket addresses were geocoded and differential distances from home to program-designated supermarkets versus competing supermarkets were calculated...
March 1, 2017: American Journal of Health Behavior
https://www.readbyqxmd.com/read/28417432/evaluating-community-measures-of-healthy-food-access
#13
Melissa L Santorelli, Janice O Okeke
Several community level measures of healthy food access exist, but evaluation efforts have been limited leaving uncertainty about how to prioritize communities for intervention. This study aimed to assess several existing measures to inform statewide public health planning efforts in New Jersey, USA. We assessed agreement between community measures of healthy food access and then evaluated the predictive validity of each measure by describing its association with complete fruit and vegetable cash-value voucher redemption (proportion redeemed ≥70, ≥80, ≥90%) among 30,078 low-income households participating in the New Jersey Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) during 2013-2014...
April 17, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28416691/neurophysiological-dynamics-of-phrase-structure-building-during-sentence-processing
#14
Matthew J Nelson, Imen El Karoui, Kristof Giber, Xiaofang Yang, Laurent Cohen, Hilda Koopman, Sydney S Cash, Lionel Naccache, John T Hale, Christophe Pallier, Stanislas Dehaene
Although sentences unfold sequentially, one word at a time, most linguistic theories propose that their underlying syntactic structure involves a tree of nested phrases rather than a linear sequence of words. Whether and how the brain builds such structures, however, remains largely unknown. Here, we used human intracranial recordings and visual word-by-word presentation of sentences and word lists to investigate how left-hemispheric brain activity varies during the formation of phrase structures. In a broad set of language-related areas, comprising multiple superior temporal and inferior frontal sites, high-gamma power increased with each successive word in a sentence but decreased suddenly whenever words could be merged into a phrase...
May 2, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28413249/agricultural-input-credit-in-sub-saharan-africa-telling-myth-from-facts
#15
Serge G Adjognon, Lenis Saweda O Liverpool-Tasie, Thomas A Reardon
Recent evidence shows that many Sub-Saharan African farmers use modern inputs, but there is limited information on how these inputs are financed. We use recent nationally representative data from four countries to explore input financing and the role of credit therein. A number of our results contradict "conventional wisdom" found in the literature. Our results consistently show that traditional credit use, formal or informal, is extremely low (across credit type, country, crop and farm size categories). Instead, farmers primarily finance modern input purchases with cash from nonfarm activities and crop sales...
February 2017: Food Policy
https://www.readbyqxmd.com/read/28410338/multiple-sources-of-prescription-payment-and-risky-opioid-therapy-among-veterans
#16
William C Becker, Brenda T Fenton, Cynthia A Brandt, Erin L Doyle, Joseph Francis, Joseph L Goulet, Brent A Moore, Virginia Torrise, Robert D Kerns, Peter W Kreiner
BACKGROUND: Opioid overdose and other related harms are a major source of morbidity and mortality among US Veterans, in part due to high-risk opioid prescribing. OBJECTIVES: We sought to determine whether having multiple sources of payment for opioids-as a marker for out-of-system access-is associated with risky opioid therapy among veterans. RESEARCH DESIGN: Cross-sectional study examining the association between multiple sources of payment and risky opioid therapy among all individuals with Veterans Health Administration (VHA) payment for opioid analgesic prescriptions in Kentucky during fiscal year 2014-2015...
July 2017: Medical Care
https://www.readbyqxmd.com/read/28398014/brain-responsive-neurostimulation-in-patients-with-medically-intractable-mesial-temporal-lobe-epilepsy
#17
Eric B Geller, Tara L Skarpaas, Robert E Gross, Robert R Goodman, Gregory L Barkley, Carl W Bazil, Michael J Berg, Gregory K Bergey, Sydney S Cash, Andrew J Cole, Robert B Duckrow, Jonathan C Edwards, Stephan Eisenschenk, James Fessler, Nathan B Fountain, Alicia M Goldman, Ryder P Gwinn, Christianne Heck, Aamar Herekar, Lawrence J Hirsch, Barbara C Jobst, David King-Stephens, Douglas R Labar, James W Leiphart, W Richard Marsh, Kimford J Meador, Eli M Mizrahi, Anthony M Murro, Dileep R Nair, Katherine H Noe, Yong D Park, Paul A Rutecki, Vicenta Salanova, Raj D Sheth, Donald C Shields, Christopher Skidmore, Michael C Smith, David C Spencer, Shraddha Srinivasan, William Tatum, Paul C Van Ness, David G Vossler, Robert E Wharen, Gregory A Worrell, Daniel Yoshor, Richard S Zimmerman, Kathy Cicora, Felice T Sun, Martha J Morrell
OBJECTIVE: Evaluate the seizure-reduction response and safety of mesial temporal lobe (MTL) brain-responsive stimulation in adults with medically intractable partial-onset seizures of mesial temporal lobe origin. METHODS: Subjects with mesial temporal lobe epilepsy (MTLE) were identified from prospective clinical trials of a brain-responsive neurostimulator (RNS System, NeuroPace). The seizure reduction over years 2-6 postimplantation was calculated by assessing the seizure frequency compared to a preimplantation baseline...
June 2017: Epilepsia
https://www.readbyqxmd.com/read/28386523/risk-management-issues-when-taking-locum-tenens-assignments
#18
Charles D Cash
This ongoing column is dedicated to providing information to our readers on managing legal risks associated with medical practice. We invite questions from our readers. The answers are provided by PRMS, Inc. (www.prms.com), a manager of medical professional liability insurance programs with services that include risk management consultation, education and onsite risk management audits, and other resources to healthcare providers to help improve patient outcomes and reduce professional liability risk. The answers published in this column represent those of only one risk management consulting company...
January 2017: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/28378958/child-poverty-the-great-recession-and-the-social-safety-net-in-the-united-states
#19
Marianne Bitler, Hiliary Hoynes, Elira Kuku
In this paper, we comprehensively examine the effects of the Great Recession on child poverty, with particular attention to the role of the social safety net in mitigating the adverse effects of shocks to earnings and income. Using a state panel data model and data for 2000 to 2014, we estimate the relationship between the business cycle and child poverty, and we examine how and to what extent the safety net is providing protection to at-risk children. We find compelling evidence that the safety net provides protection; that is, the cyclicality of after-tax-and-transfer child poverty is significantly attenuated relative to the cyclicality of private income poverty...
2017: Journal of Policy Analysis and Management
https://www.readbyqxmd.com/read/28364000/anti-pd-l1-efficacy-can-be-enhanced-by-inhibition-of-myeloid-derived-suppressor-cells-with-a-selective-inhibitor-of-pi3k%C3%AE-%C3%AE
#20
Ruth J Davis, Ellen C Moore, Paul E Clavijo, Jay Friedman, Harrison Cash, Zhong Chen, Chris Silvin, Carter Van Waes, Clint Allen
Checkpoint inhibitors are relatively inefficacious in head and neck cancers, despite an abundance of genetic alterations and a T-cell-inflamed phenotype. One significant barrier to efficacy may be the recruitment of myeloid-derived suppressor cells (MDSC) into the tumor microenvironment. Here we demonstrate functional inhibition of MDSC with IPI-145, an inhibitor of PI3Kδ and PI3Kγ isoforms, which enhances responses to PD-L1 blockade. Combination therapy induced CD8(+) T lymphocyte-dependent primary tumor growth delay and prolonged survival only in T-cell-inflamed tumor models of head and neck cancers...
May 15, 2017: Cancer Research
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