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https://www.readbyqxmd.com/read/29772868/-significance-of-cell-autophagy-in-resorption-of-lumbar-disc-herniation
#1
REVIEW
Zhi-Jun Diao, Hong Jiang, Jin-Tao Liu
As a self-protective mechanism of cells, autophagy of cells can maintain cell stability by degrading self-aging substances, and it can be highly induced. The ability of autophagy to degraded cells will decrease with age. The resorption phenomenon after lumbar disc herniation is one of the effective mechanisms in conservative treatment of lumbar disc herniation. The degenerative lesion of intervertebral disc is one of the main reasons of lumbar disc herniation. Cell autophagy is extensive participation in the degeneration of lumbar intervertebral disc, delaying the occurrence of degenerative disease...
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29769157/the-role-of-performance-quality-in-adolescents-self-evaluation-and-rumination-after-a-speech-is-it-contingent-on-social-anxiety-level
#2
Anke W Blöte, Anne C Miers, Esther Van den Bos, P Michiel Westenberg
BACKGROUND: Cognitive behavioural therapy (CBT) has relatively poor outcomes for youth with social anxiety, possibly because broad-based CBT is not tailored to their specific needs. Treatment of social anxiety in youth may need to pay more attention to negative social cognitions that are considered a key factor in social anxiety development and maintenance. AIMS: The aim of the present study was to learn more about the role of performance quality in adolescents' cognitions about their social performance and, in particular, the moderating role social anxiety plays in the relationship between performance quality and self-cognitions...
May 17, 2018: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29769121/anxiety-and-depression-in-primary-sj%C3%A3-gren-s-syndrome-a-cross-sectional-study
#3
Yafei Cui, Ling Xia, Lin Li, Qian Zhao, Shengnan Chen, Zhifeng Gu
BACKGROUND: Prevalence of anxiety and depression is high in people with Primary Sjögren's syndrome (pSS). However, there are currently no known reported studies about anxiety/depression in pSS patients from China. Our aim was to compare anxiety/depression in pSS patients and healthy controls; to investigate the prevalence of anxiety and/or depression among pSS patients in China; to evaluate its relationship with the disease activity, fatigue, pain, education, ocular surface disease, oral health, swallowing disorders, employment status, European League Against Rheumatism Sjögren's Syndrome Patient Reported Index(ESSPRI) as well as to analyze potential determinants of anxiety and depression...
May 16, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29768265/disease-burden-psychological-well-being-and-attitudes-regarding-the-set-of-emergency-medication-in-adults-with-insect-venom-allergy
#4
Marthe-Lisa Schaarschmidt, Mandy Gutknecht, Lisa Schoeben, Astrid Schmieder
BACKGROUND: Insect venom allergy is common and greatly impairs patients' quality of life. Additionally, low compliance with carrying emergency medication is reported. The aim of our study was to analyze the disease burden, levels of anxiety and depression, and to evaluate attitudes towards the set of emergency medication in affected patients. METHODS: Between April 2016 and January 2017, patients ≥18 years visiting our department because of an insect venom allergy were asked to complete a paper-based questionnaire...
May 16, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29767641/willingness-to-pay-for-hiv-self-tests-among-women-in-kenya-implications-for-subsidy-and-pricing-policies
#5
Harsha Thirumurthy, Samuel H Masters, Kawango Agot
No abstract text is available yet for this article.
June 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29762464/the-mediating-effect-of-regulatory-emotional-self-efficacy-on-the-association-between-self-esteem-and-school-bullying-in-middle-school-students-a-cross-sectional-study
#6
Xiaoqin Wang, Yue Zhang, Zhaozhao Hui, Wanyue Bai, Paul D Terry, Mei Ma, Yang Li, Li Cheng, Wei Gu, Mingxu Wang
School bullying is negatively associated with self-esteem, but psychological mediators of bullying have yet to be clarified. We examined regulatory emotional self-efficacy (RESE) as a possible mediator in the association between self-esteem and school bullying. A cross-sectional study of 995 adolescents was conducted in two middle schools of Xi'an. All of the participants completed the Chinese version of the School Bullying Experience Questionnaire (C-SBEQ), Self-Esteem Scale (SES), and Regulatory Emotional Self-Efficacy Scale (RESE)...
May 15, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29759056/housing-and-employment-outcomes-for-mental-health-self-direction-participants
#7
Bevin Croft, Nilüfer İsvan, Susan L Parish, Kevin J Mahoney
OBJECTIVE: In self-direction, participants control individual budgets, allocating service dollars according to needs and preferences within program parameters to meet self-defined recovery goals. Mental health self-direction is associated with enhanced wellness and recovery outcomes at lower or similar cost than traditional service arrangements. This study compared outcomes of housing independence and employment between individuals who participated in self-direction and those who did not...
May 15, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29750644/the-meteoric-rise-and-dramatic-fall-of-theranos-lessons-learned-for-the-diagnostic-industry
#8
Clare Fiala, Eleftherios P Diamandis
In this piece we discuss and reflect on the conclusion of the Theranos saga in the light of its fraud conviction. Theranos (founded in 2003 by Elizabeth Holmes) was supposed to disrupt the diagnostic testing industry by developing technology which could perform dozens of tests using a tiny amount of blood from a finger-prick. As a result, Ms. Holmes rose to fame, becoming the world's youngest female self-made billionaire and was plastered across magazine covers. However, in 2014, Theranos began to fall apart following increasingly damaging revelations regarding its lack of expertise, technology, framework, extreme secrecy and inaccurate test results...
May 11, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29743941/cost-effectiveness-of-dialectical-behaviour-therapy-vs-enhanced-usual-care-in-the-treatment-of-adolescents-with-self-harm
#9
Egil Haga, Eline Aas, Berit Grøholt, Anita J Tørmoen, Lars Mehlum
Background: Studies have shown that dialectical behaviour therapy (DBT) is effective in reducing self-harm in adults and adolescents. Aims: To evaluate the cost-effectiveness of DBT for adolescents (DBT-A) compared to enhanced usual care (EUC). Methods: In a randomised study, 77 adolescents with repeated self-harm were allocated to 19 weeks of outpatient treatment, either DBT-A ( n  = 39) or EUC ( n  = 38). Cost-effective analyses, including estimation of incremental cost-effectiveness ratios, were conducted with self-harm and global functioning (CGAS) as health outcomes...
2018: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/29741267/health-care-providers-perspectives-on-health-insurance-access-waiving-procedures-and-hospital-detention-practices-in-kenya
#10
Saskia Mostert, Festus Njuguna, Renske H M van der Burgt, Joyce Musimbi, Sandra Langat, Jodi Skiles, Anneloes Seijffert, Mei N Sitaresmi, Terry A Vik, Peter M van de Ven, Gertjan J L Kaspers
BACKGROUND: Patients at Kenyan public hospitals are detained if their families cannot pay their medical bills. Access to health insurance and waiving procedures to prevent detention may be limited. This study explores the perspectives of health-care providers (HCP) on health-insurance access, waiving procedures, and hospital detention practices. PROCEDURE: A self-administered structured questionnaire was completed by 104 HCP (response rate 78%) involved in childhood cancer care...
May 9, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29740804/colorectal-cancer-screening-preferences-past-behavior-and-future-intentions
#11
Carol Mansfield, Donatus U Ekwueme, Florence K L Tangka, Derek S Brown, Judith Lee Smith, Gery P Guy, Chunyu Li, Brett Hauber
BACKGROUND: Screening rates for colorectal cancer are below the Healthy People 2020 goal. There are several colorectal cancer screening tests that differ in terms of accuracy, recommended frequency, and administration. In this article, we compare how a set of personal characteristics correlates with preferences for colorectal cancer screening test attributes, past colorectal cancer screening behavior, and future colorectal cancer screening intentions. METHODS: We conducted a discrete-choice experiment survey to assess relative preferences for attributes of colorectal cancer screening tests among adults aged 50-75 years in USA...
May 9, 2018: Patient
https://www.readbyqxmd.com/read/29738398/revenue-for-initial-orthopaedic-trauma-care-effects-of-patient-and-injury-characteristics
#12
Christopher D Flanagan, Alexander S Rascoe, David M Wang, Heather Vallier
OBJECTIVE: To characterize the charges and collections associated with the initial inpatient management of trauma patients who undergo operative fracture management DESIGN:: Retrospective SETTING:: Level 1 trauma center PARTICIPANTS:: 440 consecutive adult trauma patients INTERVENTION:: fixation for fracture of the spine, pelvis, acetabulum, and/or femur fractures MAIN OUTCOME MEASUREMENT:: Professional and technical (facility) charges and collections from the initial inpatient management and 6 months of subsequent related care RESULTS:: Patient were predominantly male (74...
May 3, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29731412/comparison-of-effectiveness-and-cost-effectiveness-of-an-intensive-community-supported-discharge-service-versus-treatment-as-usual-for-adolescents-with-psychiatric-emergencies-a-randomised-controlled-trial
#13
Dennis Ougrin, Richard Corrigall, Jason Poole, Toby Zundel, Mandy Sarhane, Victoria Slater, Daniel Stahl, Paula Reavey, Sarah Byford, Margaret Heslin, John Ivens, Maarten Crommelin, Zahra Abdulla, Daniel Hayes, Kerry Middleton, Benita Nnadi, Eric Taylor
BACKGROUND: Intensive community treatment to reduce dependency on adolescent psychiatric inpatient care is recommended in guidelines but has not been assessed in a randomised controlled trial in the UK. We designed a supported discharge service (SDS) provided by an intensive community treatment team and compared outcomes with usual care. METHODS: Eligible patients for this randomised controlled trial were younger than 18 years and had been admitted for psychiatric inpatient care in the South London and Maudsley NHS Foundation Trust...
May 3, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29730344/the-cost-effectiveness-of-self-expandable-transcatheter-aortic-valves-in-intermediate-risk-patients
#14
Derrick Y Tam, Avery Hughes, Harindra C Wijeysundera, Stephen E Fremes
BACKGROUND: A recent clinical trial showed that self-expandable transcatheter aortic valve replacement (TAVR) was non-inferior to surgical aortic valve replacement (SAVR). However, the cost-effectiveness of self-expandable TAVR in the intermediate risk population remains unknown. METHODS: A cost-utility analysis from the Canadian healthcare system payer's perspective was undertaken comparing self-expandable TAVR to SAVR. A fully probabilistic Markov model over the patient's life-time was constructed to estimate differences in costs (2016 Canadian dollars) and effectiveness (quality-adjusted life-years (QALYs)), discounted at 1...
May 3, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29724200/cigarette-waterpipe-and-e-cigarette-use-among-an-international-sample-of-medical-students-cross-sectional-multicenter-study-in-germany-and-hungary
#15
Erika Balogh, Nóra Faubl, Henna Riemenschneider, Péter Balázs, Antje Bergmann, Károly Cseh, Ferenc Horváth, Jörg Schelling, András Terebessy, Zoltán Wagner, Karen Voigt, Zsuzsanna Füzesi, István Kiss
BACKGROUND: Tobacco use is the leading preventable cause of death worldwide. Besides cigarette smoking, waterpipe and e-cigarettes are gaining popularity among young adults. Medical students' smoking behavior is of particular interest because of their impending role in health promotion as future physicians. Aim of our study is to examine the prevalence and predictors of cigarette, waterpipe and e-cigarette use and the association of tobacco use with self-reported health status in an international sample of medical students...
May 3, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29713237/effective-instruction-for-persisting-dyslexia-in-upper-grades-adding-hope-stories-and-computer-coding-to-explicit-literacy-instruction
#16
Robert Thompson, Steve Tanimoto, Ruby Dawn Lyman, Kira Geselowitz, Kristin Kawena Begay, Kathleen Nielsen, William Nagy, Robert Abbott, Marshall Raskind, Virginia Berninger
Children in grades 4 to 6 ( N =14) who despite early intervention had persisting dyslexia (impaired word reading and spelling) were assessed before and after computerized reading and writing instruction aimed at subword, word, and syntax skills shown in four prior studies to be effective for treating dyslexia. During the 12 two-hour sessions once a week after school they first completed HAWK Letters in Motion© for manuscript and cursive handwriting, HAWK Words in Motion© for phonological, orthographic, and morphological coding for word reading and spelling, and HAWK Minds in Motion© for sentence reading comprehension and written sentence composing...
May 2018: Education and information technologies
https://www.readbyqxmd.com/read/29707218/the-generic-drug-user-fee-amendments-an-economic-perspective
#17
Ernst R Berndt, Rena M Conti, Stephen J Murphy
Since the vast majority of prescription drugs consumed by Americans are off patent ('generic'), their regulation and supply is of wide interest. We describe events leading up to the US Congress's 2012 passage of the Generic Drug User Fee Amendments (GDUFA I) as part of the Food and Drug Administration Safety and Innovation Act (FDASIA). Under GDUFA I, generic manufacturers agreed to pay approximately $300 million in fees each year of the five-year program. In exchange, the US Food and Drug Administration (FDA) committed to performance goals...
May 2018: Journal of Law and the Biosciences
https://www.readbyqxmd.com/read/29704216/attentional-capacities-prior-to-drug-exposure-predict-motivation-to-self-administer-nicotine
#18
Youna Vandaele, Emilie Noe, Martine Cador, Françoise Dellu-Hagedorn, Stephanie Caille
RATIONALE: Nicotine can enhance attention and attribution of incentive salience to nicotine-associated stimuli. However, it is not clear whether inter-individual differences in attentional capacities prior to any exposure could play a role in vulnerability to nicotine self-administration. We further explored this vulnerability through pre-existing inter-individual differences in attention to a reward-predictive cue in drug-free animals. METHODS: A cued version of the Fixed Consecutive Number schedule (FCN16cue ) of reinforcement task was used to assess attention...
April 27, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29694324/do-cooperative-learning-and-family-involvement-improve-variables-linked-to-academic-performance
#19
Miguel A Santos Rego, María J Ferraces Otero, Agustín Godas Otero, María M Lorenzo Moledo
BACKGROUND: One of the most serious problems in the Spanish education system is the high percentage of school failure in Compulsory Secondary Education. The aim of this study is to analyze the influence of a socio-educational program based on cooperative learning and family involvement on a series of variables related to academic performance, paying particular attention to the differences between retained and non-retained students. METHODOLOGY: A two-group quasi-experimental design incorporating pre-testing and post-testing was used...
May 2018: Psicothema
https://www.readbyqxmd.com/read/29693968/determinants-of-breast-cancer-screening-by-mammography-in-women-referred-to-health-centers-of-urmia-iran
#20
Fatemeh Moghaddam Tabrizi, Sakineh Vahdati, Shahriar Khanahmadi, Samira Barjasteh
Background: In women, breast cancer accounts for 30 percent of all cancers and it is the second leading cause of mortality. Mammography is considered an effective procedure to detect early breast cancer recommended by World Health Organization. This study was aimed to evaluate breast cancer screening determinants in women referred to health centers of Urmia for mammography in 2017. Materials and Methods: In this descriptive-analytic cross-sectional study, 348 women referred to health centers of Urmia were selected using multistage sampling...
April 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
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