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https://www.readbyqxmd.com/read/28100701/self-cytoplasmic-dna-upregulates-the-mutator-enzyme-apobec3a-leading-to-chromosomal-dna-damage
#1
Rodolphe Suspène, Bianka Mussil, Hélène Laude, Vincent Caval, Noémie Berry, Mohamed S Bouzidi, Valérie Thiers, Simon Wain-Hobson, Jean-Pierre Vartanian
Foreign and self-cytoplasmic DNA are recognized by numerous DNA sensor molecules leading to the production of type I interferons. Such DNA agonists should be degraded otherwise cells would be chronically stressed. Most human APOBEC3 cytidine deaminases can initiate catabolism of cytoplasmic mitochondrial DNA. Using the human myeloid cell line THP-1 with an interferon inducible APOBEC3A gene, we show that cytoplasmic DNA triggers interferon α and β production through the RNA polymerase III transcription/RIG-I pathway leading to massive upregulation of APOBEC3A By catalyzing C→U editing in single stranded DNA fragments, the enzyme prevents them from re-annealing so attenuating the danger signal...
January 18, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28095759/living-with-end-stage-renal-disease
#2
Karen Schipper, Elleke Landeweer, Tineke A Abma
BACKGROUND: Living with a renal disease often reduces quality of life because of the stress it entails. No attention has been paid to the moral challenges of living with renal disease. OBJECTIVES: To explore the moral challenges of living with a renal disease. RESEARCH DESIGN: A case study based on qualitative research. We used Walker's ethical framework combined with narrative ethics to analyse how negotiating care responsibilities lead to a new perspective on moral issues...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28091762/good-jobs-good-pay-better-health-the-effects-of-job-quality-on-health-among-older-european-workers
#3
Golo Henseke
Using data from the Survey of Health, Ageing and Retirement in Europe, this study presents new evidence on the effects of job quality on the occurrence of severe acute conditions, the level of cardiovascular risk factors, musculoskeletal disorders, mental health, functional disabilities and self-assessed health among workers aged 50+. By combining intrinsic job quality with job insecurity and pay the study maps out multiple potential pathways through which work may affect health and well-being. Levering longitudinal data and external information on early retirement ages allows for accounting of unobserved heterogeneity, selection bias and reverse causality...
January 13, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28088840/evaluation-of-a-short-term-training-program-in-bedside-emergency-ultrasound-in-southwestern-tanzania
#4
Mark Shaffer, Heather A Brown, Chloé McCoy, Prosper Bashaka
OBJECTIVES: To evaluate the effect of a short-term training program in emergency ultrasound on physician skills and attitudes in southwestern Tanzania. METHODS: Eight registrar physicians at Mbeya Zonal Referral Hospital (Mbeya, Tanzania) underwent a 5-day course in bedside emergency ultrasound, focusing primarily on the focused assessment with sonography for trauma examination, including didactic sessions, practical sessions, and on-job training. The impact on ultrasound knowledge was assessed by pretest and posttest evaluations...
January 15, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28086867/process-evaluation-of-an-integrated-care-pathway-in-geriatric-rehabilitation-for-people-with-complex-health-problems
#5
Irma H J Everink, Jolanda C M van Haastregt, Jose M C Maessen, Jos M G A Schols, Gertrudis I J M Kempen
BACKGROUND: An integrated care pathway in geriatric rehabilitation was developed to improve coordination and continuity of care for community-living older adults in the Netherlands, who go through the process of hospital admission, admission to a geriatric rehabilitation facility and discharge back to the home situation. This pathway is a complex intervention and is focused on improving communication, triage and transfers of patients between the hospital, geriatric rehabilitation facility and primary care organisations...
January 13, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28056347/paying-attention-to-the-cortical-layers
#6
Matthew W Self, Pieter R Roelfsema
In this issue of Neuron, Nandy et al. (2017) reveal a number of important new insights into the neural mechanisms that are responsible for attentional selection.
January 4, 2017: Neuron
https://www.readbyqxmd.com/read/28052841/preventing-depression-in-adults-with-subthreshold-depression-health-economic-evaluation-alongside-a-pragmatic-randomized-controlled-trial-of-a-web-based-intervention
#7
Claudia Buntrock, Matthias Berking, Filip Smit, Dirk Lehr, Stephanie Nobis, Heleen Riper, Pim Cuijpers, David Ebert
BACKGROUND: Psychological interventions for the prevention of depression might be a cost-effective way to reduce the burden associated with depressive disorders. OBJECTIVE: To evaluate the cost-effectiveness of a Web-based guided self-help intervention to prevent major depressive disorder (MDD) in people with subthreshold depression (sD). METHODS: A pragmatic randomized controlled trial was conducted with follow-up at 12 months. Participants were recruited from the general population via a large statutory health insurance company and an open access website...
January 4, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28052158/factors-associated-with-nontransfer-in-trauma-patients-meeting-american-college-of-surgeons-criteria-for-transfer-at-nontertiary-centers
#8
Quanhong Zhou, Matthew R Rosengart, Timothy R Billiar, Andrew B Peitzman, Jason L Sperry, Joshua B Brown
Importance: Secondary triage from nontertiary centers is vital to trauma system success. It remains unclear what factors are associated with nontransfer among patients who should be considered for transfer to facilities providing higher-level care. Objective: To identify factors associated with nontransfer among patients meeting American College of Surgeons (ACS) guideline criteria for transfer from nontertiary centers. Design, Setting, and Participants: A retrospective cohort study was performed using multilevel logistic regression to ascertain factors associated with nontransfer from nontertiary centers, including demographics, injury characteristics, and center resources...
January 4, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28049343/defining-the-rate-of-negative-ureteroscopy-in-the-general-population-treated-for-upper-tract-urinary-stone-disease
#9
Remy W Lamberts, Simon L Conti, John T Leppert, Christopher S Elliott
INTRODUCTION: Ureteroscopy is increasingly used to treat upper tract urinary stone disease. A negative ureteroscopy is a ureteroscopy performed with the intent of removing a kidney or ureteral stone, but in which ultimately no stone is removed. Negative ureteroscopy may occur when the stone is found to have already passed, or the presumed stone is found to be outside of the collecting system. We sought to determine the rate of negative ureteroscopy in a large population-based sample as well as factors associated with its use...
January 3, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28034651/patient-surgeon-and-hospital-disparities-associated-with-benign-hysterectomy-approach-and-perioperative-complications
#10
Ambar Mehta, Tim Xu, Susan Hutfless, Martin A Makary, Abdulrahman K Sinno, Edward J Tanner, Rebecca L Stone, Karen Wang, Amanda N Fader
BACKGROUND: Hysterectomy is among the most common major surgical procedures performed in women. Approximately 450,000 hysterectomy procedures are performed each year in the United States for benign indications. However, little is known regarding contemporary U.S. hysterectomy trends for women with benign disease with respect to operative technique and perioperative complications, and the association between these two factors with patient, surgeon, and hospital characteristics. OBJECTIVES: To describe contemporary hysterectomy trends and explore associations between patient, surgeon, and hospital characteristics with surgical approach and perioperative complications...
December 26, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28028288/a-cost-effectiveness-analysis-of-self-debriefing-versus-instructor-debriefing-for-simulated-crises-in-perioperative-medicine-in-canada
#11
Wanrudee Isaranuwatchai, Fahad Alam, Jeffrey Hoch, Sylvain Boet
PURPOSE: High-fidelity simulation training is effective for learning crisis resource management (CRM) skills, but cost is a major barrier to implementing high-fidelity simulation training into the curriculum. The aim of this study was to examine the cost-effectiveness of self-debriefing and traditional instructor debriefing in CRM training programs and to calculate the minimum willingness-to-pay (WTP) value when one debriefing type becomes more cost-effective than the other. METHODS: This study used previous data from a randomized controlled trial involving 50 anesthesiology residents in Canada...
2017: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/28025950/age-differences-in-the-use-of-serving-size-information-on-food-labels-numeracy-or-attention
#12
Lisa M Soederberg Miller, Elizabeth Applegate, Laurel A Beckett, Machelle D Wilson, Tanja N Gibson
OBJECTIVE: The ability to use serving size information on food labels is important for managing age-related chronic conditions such as diabetes, obesity and cancer. Past research suggests that older adults are at risk for failing to accurately use this portion of the food label due to numeracy skills. However, the extent to which older adults pay attention to serving size information on packages is unclear. We compared the effects of numeracy and attention on age differences in accurate use of serving size information while individuals evaluated product healthfulness...
December 27, 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/28018256/typing-style-and-the-use-of-different-sources-of-information-during-typing-an-investigation-using-self-reports
#13
Martina Rieger, Victoria K E Bart
We investigated to what extent different sources of information are used in typing on a computer keyboard. Using self-reports 10 finger typists and idiosyncratic typists estimated how much attention they pay to different sources of information during copy typing and free typing and how much they use them for error detection. 10 finger typists reported less attention to the keyboard and the fingers and more attention to the template and the screen than idiosyncratic typists. The groups did not differ in attention to touch/kinaesthesis in copy typing and free typing, but 10 finger typists reported more use of touch/kinaesthesis in error detection...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/28000904/honoring-the-work-and-life-of-leroy-c-stevens-a-symposium-as-part-of-the-international-stem-cell-initiative-workshop
#14
Christopher F Graham, Davor Solter, John D Gearhart, Joseph H Nadeau, Barbara B Knowles
In 2016, a symposium was convened in Leroy C. Stevens' honor, in association with a meeting of the International Stem Cell Initiative (ISCI). ISCI, funded internationally, is composed of a group of ~100 scientists from many countries, under the leadership of Peter Andrews, who have worked together to characterize a significant number of human pluripotent stem cell lines, to monitor their genetic stability and their differentiation into mature cell types and tissues in vitro and in vivo. Those at the ISCI meeting puzzled through one of the thorniest problems in the therapeutic use of the differentiated derivatives of pluripotent stem cells for human therapy; namely, pluripotent stem cells can differentiate into any cell type in the adult organism, but they also have the capacity for unlimited self-renewal, hence if mutated they may have tumorigenic potential...
2016: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/27994864/diabetic-kidney-disease-patients-on-hemodialysis-a-retrospective-survival-analysis-across-different-socioeconomic-groups
#15
Madhusudan Vijayan, Saranya Radhakrishnan, Georgi Abraham, Milly Mathew, Krishnaswamy Sampathkumar, Nevin Philip Mancha
BACKGROUND: Diabetic kidney disease is the leading cause of stage 5 chronic kidney disease (CKD) in India. Renal replacement therapy (RRT) is accessible to very few patients because of socioeconomic deprivation. We studied the effect of diabetes and socioeconomic status on the outcome of patients on maintenance hemodialysis (MHD). METHODS: We retrospectively analyzed the outcome of 897 patients (629 males/268 females; mean age ± standard deviation 48.69 ± 14.27 years) initiated on MHD from 2003 to 2009 at five dialysis centers in south India...
December 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27993738/increased-utilization-of-cervical-disk-arthroplasty-in-university-hospitals-with-regional-variation-and-socioeconomic-discrepancies
#16
Sheri K Palejwala, Anand I Rughani, Travis M Dumont
OBJECTIVE: Treatment of cervical radiculopathy with disk arthroplasty has been FDA approved since 2007. Recently, a significant increase in clinical data including middle and long-term follow-up has become available, demonstrating superiority of disk arthroplasty compared with anterior discectomy and fusion. The aim of this project is to assess nationwide utilization of cervical disk arthroplasty. METHODS: The University Healthcare Consortium (UHC) database was accessed for all elective cases of patients treated for cervical radiculopathy due to disk herniation (ICD 722...
December 16, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27982378/factors-associated-with-low-adherence-to-medicine-treatment-for-chronic-diseases-in-brazil
#17
Noemia Urruth Leão Tavares, Andréa Dâmaso Bertoldi, Sotero Serrate Mengue, Paulo Sergio Dourado Arrais, Vera Lucia Luiza, Maria Auxiliadora Oliveira, Luiz Roberto Ramos, Mareni Rocha Farias, Tatiane da Silva Dal Pizzol
OBJECTIVE: To analyze factors associated with low adherence to drug treatment for chronic diseases in Brazil. METHODS: Analysis of data from Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM - Brazilian Survey on Access, Use and Promotion of Rational Use of Medicines), a population-based cross-sectional household survey, based on a probabilistic sample of the Brazilian population. We analyzed the association between low adherence to drug treatment measured by the Brief Medication Questionnaire and demographic, socioeconomic, health, care and prescription factors...
December 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/27980882/impact-of-helmet-use-on-injury-and-financial-burden-of-motorcycle-and-moped-crashes-in-hawai-i-analysis-of-a-linked-statewide-database
#18
Daniel J Galanis, Nikki A Castel, Linda L Wong, Susan Steinemann
Helmet use reduces injury severity, disability, hospital length of stay, and hospital charges in motorcycle riders. The public absorbs billions of dollars annually in hospital charges for unhelmeted, uninsured motorcycle riders. We sought to quantify, on a statewide level, the healthcare burden of unhelmeted motorcycle and moped riders. We examined 1,965 emergency medical service (EMS) reports from motorcycle and moped crashes in Hawai'i between 2007-2009. EMS records were linked to hospital medical records to assess associations between vehicle type, helmet use, medical charges, diagnoses, and final disposition...
December 2016: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/27968852/doctor-outpatient-communications-in-chinese-public-hospitals-a-cross-sectional-survey
#19
Guanping Wang, Jinzhu Xie, Yinhuan Hu
BACKGROUND: Communication can be seen as the important component in medical care. The improvement of doctor-outpatient communication can improve not only the doctor-patient relationship, but also the quality of health care. In this study, we aimed to estimate whether the doctor-outpatient communication experience is satisfactory in Chinese public hospitals and how various factors affect this experience. METHODS: In this cross-sectional study, we used a typical sampling survey...
October 2016: Lancet
https://www.readbyqxmd.com/read/27965610/identification-of-socio-demographic-and-psychological-factors-affecting-women-s-propensity-to-breastfeed-an-italian-cohort
#20
Valentina E Di Mattei, Letizia Carnelli, Martina Bernardi, Chiara Jongerius, Chiara Brombin, Federica Cugnata, Anna Ogliari, Stefania Rinaldi, Massimo Candiani, Lucio Sarno
Background: Exclusive breastfeeding until 6 months postpartum is a World Health Organization objective and benefits have been demonstrated for both mother and infant. It is important to clarify which factors influence breastfeeding intentions. Our objective was to assess and identify socio-demographic and psychological factors associated with breastfeeding intention in a sample of pregnant Italian women. Materials and Methods: This prospective study included 160 pregnant women. The following psychological constructs were measured using standardized questionnaires: anxiety, prenatal attachment, adult attachment, personality traits, and intention to breastfeed...
2016: Frontiers in Psychology
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