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https://www.readbyqxmd.com/read/28727701/randomized-placebo-controlled-placebo-trial-to-determine-the-placebo-effect-size
#1
Ludger Gerdesmeyer, Tim Klueter, Volker W Rahlfs, Munjed Al Muderis, Amol Saxena, Hans Gollwitzer, Norbert Harrasser, Martin Stukenberg, Alexander Prehn-Kristensen
BACKGROUND: It is the gold standard to use a placebo treatment as the control group in prospective randomized controlled trials (RCTs). Although placebo-controlled trials can reveal an effect of an active treatment, the pure effect of a placebo treatment alone has never been presented or evaluated. No evidence-based, placebo-therapeutic options are currently available, and no placebo-controlled trials have been performed to elucidate the pure placebo effect. OBJECTIVES: To analyze the pure placebo effect on clinical, chronic pain through a blinded RCT...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28727539/state-and-local-chronic-disease-surveillance-using-electronic-health-record-systems
#2
Michael Klompas, Noelle M Cocoros, John T Menchaca, Diana Erani, Ellen Hafer, Brian Herrick, Mark Josephson, Michael Lee, Michelle D Payne Weiss, Bob Zambarano, Karen R Eberhardt, Jessica Malenfant, Laura Nasuti, Thomas Land
OBJECTIVES: To assess the feasibility of chronic disease surveillance using distributed analysis of electronic health records and to compare results with Behavioral Risk Factor Surveillance System (BRFSS) state and small-area estimates. METHODS: We queried the electronic health records of 3 independent Massachusetts-based practice groups using a distributed analysis tool called MDPHnet to measure the prevalence of diabetes, asthma, smoking, hypertension, and obesity in adults for the state and 13 cities...
July 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28727518/therapeutic-and-prognostic-implications-of-braf-v600e-in-pediatric-low-grade-gliomas
#3
Alvaro Lassaletta, Michal Zapotocky, Matthew Mistry, Vijay Ramaswamy, Marion Honnorat, Rahul Krishnatry, Ana Guerreiro Stucklin, Nataliya Zhukova, Anthony Arnoldo, Scott Ryall, Catriona Ling, Tara McKeown, Jim Loukides, Ofelia Cruz, Carmen de Torres, Cheng-Ying Ho, Roger J Packer, Ruth Tatevossian, Ibrahim Qaddoumi, Julie H Harreld, James D Dalton, Jean Mulcahy-Levy, Nicholas Foreman, Matthias A Karajannis, Shiyang Wang, Matija Snuderl, Amulya Nageswara Rao, Caterina Giannini, Mark Kieran, Keith L Ligon, Maria Luisa Garre, Paolo Nozza, Samantha Mascelli, Alessandro Raso, Sabine Mueller, Theodore Nicolaides, Karen Silva, Romain Perbet, Alexandre Vasiljevic, Cécile Faure Conter, Didier Frappaz, Sarah Leary, Courtney Crane, Aden Chan, Ho-Keung Ng, Zhi-Feng Shi, Ying Mao, Elizabeth Finch, David Eisenstat, Bev Wilson, Anne Sophie Carret, Peter Hauser, David Sumerauer, Lenka Krskova, Valerie Larouche, Adam Fleming, Shayna Zelcer, Nada Jabado, James T Rutka, Peter Dirks, Michael D Taylor, Shiyi Chen, Ute Bartels, Annie Huang, David W Ellison, Eric Bouffet, Cynthia Hawkins, Uri Tabori
Purpose BRAF V600E is a potentially highly targetable mutation detected in a subset of pediatric low-grade gliomas (PLGGs). Its biologic and clinical effect within this diverse group of tumors remains unknown. Patients and Methods A combined clinical and genetic institutional study of patients with PLGGs with long-term follow-up was performed (N = 510). Clinical and treatment data of patients with BRAF V600E mutated PLGG (n = 99) were compared with a large international independent cohort of patients with BRAF V600E mutated-PLGG (n = 180)...
July 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28727341/-use-of-trabecular-bone-score-as-a-complementary-approach-to-dxa-for-fracture-risk-assessment-in-clinical-practice
#4
Didier Hans, Enisa Shevroja, Olivier Lamy
Physicians can assess the risk of fracture based on bone density (BMD) and several risk factors. Some of them and BMD are incorporated into FRAX, an assessment tool that estimates the 10-years probability of fracture. BMD didn't take into account the microarchitecture. TBS is a texture parameter related to bone microarchitecture. A low TBS is associated with a history of fracture and the incidence of new fracture independently of BMD, clinical risk factors and FRAX. TBS is yet integrated in the FRAX tool, and this effect is of greatest utility for individuals who are close to an intervention threshold...
April 19, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28726463/steven-steve-walfish-1953-2016
#5
Nadine J Kaslow, Amanda M Woods, Jeffrey Zimmerman
Presents an obituary for Steven (Steve) Walfish, who passed away in Atlanta, Georgia, on April 27, 2016. Walfish was a passionate clinical scholar and educator for independent practitioners. Well respected for his evaluations and consultations (presurgical weight loss, substance abuse, psychiatric issues), he became the go-to person for referrals for evidence-based practice with adults and couples. His untimely death to cancer deeply saddened the innumerable clients whose lives he touched and his diverse professional collaborators...
July 2017: American Psychologist
https://www.readbyqxmd.com/read/28726409/observation-of-steady-shear-induced-nematic-ordering-of-selenium-chain-moieties-in-arsenic-selenide-liquids
#6
Weidi Zhu, Galan Moore, Bruce G Aitken, Simon Clark, Sabyasachi Sen
Structural anisotropy induced by steady shear and its mechanistic relation with shear thinning are investigated in AsxSe1-x glasses (5≤x≤30) quenched from parent liquids subjected to shear rates ranging between 0 and 104 s1 using polarized Raman spectroscopy and two-dimensional x-ray diffraction. When taken together, the results demonstrate significant shear-induced partial alignment of -Se-Se-Se- chain moieties in the flow direction of the extruded fibers. This alignment is reminiscent of nematic liquid crystals where orientational order exists without positional order...
July 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28726375/nanoscale-hydrodynamic-film-for-diffusive-mass-transport-control-in-compartmentalized-microfluidic-chambers
#7
Minseok Kim, Ji Won Lim, Sung Kuk Lee, Taesung Kim
A compartmentalized microfluidic chamber array that not only offers separate cell culture environments but also independent control of the diffusion of small molecules provides an extremely useful platform for cell cultivations and versatile cellular assays. However, it is challenging to incorporate both cell compartmentalization and active diffusion control in real-time and precise manners. Here, we present a novel nanoscale hydrodynamic film (NHF) that is formed between a solid substrate and a polydimethylsiloxane (PDMS) surface...
July 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28726115/the-impact-of-coronary-calcification-on-angiographic-and-3-year-clinical-outcomes-of-everolimus-eluting-stents-results-of-a-xience-v-promus-post-marketing-surveillance-study
#8
Nobuo Shiode, Ken Kozuma, Jiro Aoki, Masaki Awata, Mamoru Nanasato, Kengo Tanabe, Junichi Yamaguchi, Hajime Kusano, Hong Nie, Takeshi Kimura
Coronary calcification (CCA) is one of the independent predictors for major adverse cardiac events (MACEs) in coronary intervention. Post-marketing surveillance study Japan is a prospective registry designed to evaluate the safety and efficacy of the everolimus-eluting stent (EES, XIENCE V/PROMUS Stent) in routine clinical practice at 47 centers. In this study, 1848 lesions (1546 patients) were assessed using quantitative coronary angiography. In these 1546 patients, renal function data were unknown in 26 patients...
July 19, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28725938/declining-radiation-dose-of-coronary-computed-tomography-angiography-german-cardiac-ct-registry-experience-2009-2014
#9
Axel Schmermund, Mohamed Marwan, Jörg Hausleiter, Sebastian Barth, Oliver Bruder, Sebastian Kerber, Grigorius Korosoglou, Alexander Leber, Werner Moshage, Stephen Schröder, Steffen Schneider, Jochen Senges, Stephan Achenbach
BACKGROUND: Coronary computed tomography angiography (CTA) is increasingly used as a test to rule out coronary artery disease (CAD) in patients with a low to intermediate pre-test probability of the disease. We used the database of the German CT registry, collected between 2009 and 2014 in a broad patient population, to analyze contemporary radiation dose associated with coronary CTA in clinical practice. PATIENTS AND METHODS: The prospective observational registry included a total of 7061 patients ≥18 years, referred to 12 participating centers for a clinically indicated cardiac CT examination...
July 19, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28725627/effect-of-yoga-training-on-lipid-metabolism-in-industrial-workers-with-reference-to-body-constitution-prakriti
#10
Suchitra Doddoli, Sanjay Shete, Dattatraya Kulkarni, Ranjit Bhogal
INTRODUCTION: The progressive increase in dyslipidemia and physical inactivity are considered to be major risk factors for the onset of non communicable diseases. Awareness of body constitution plays a vital role to regularise optimum health. The present study was planned to evaluate the effect of yoga practices on lipid metabolism with reference to specific body constitution (Prakriti). METHODS: A self-as-control study was conducted on 36 male healthy volunteers between age group of 30-58 years...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28725578/transperineal-vs-transrectal-biopsy-in-mri-targeting
#11
REVIEW
Jeremy Grummet, Lana Pepdjonovic, Sean Huang, Elliot Anderson, Boris Hadaschik
Prostate biopsy is typically performed via either the transrectal or transperineal approach. MRI-targeted biopsy, whether using any of the three options of cognitive fusion, MRI-ultrasound fusion software, or in-bore MRI-guided biopsy, can also be performed via either transrectal or transperineal approaches. As an extension of traditional random prostate biopsy, the transrectal approach is far more commonly used for MRI-targeted biopsy due to its convenience. However, in the context of today's increasing multi-drug resistance of rectal flora, the transperineal approach is being used more often due to its lack of septic complications...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725326/comparison-of-clopidogrel-with-prasugrel-and-ticagrelor-in-patients-with-acute-coronary-syndrome-clinical-outcomes-from-the-national-cardiovascular-database-action-registry
#12
Mohamed Khayata, Joseph N Gabra, M Farhan Nasser, George I Litman, Shyam Bhakta, Rupesh Raina
BACKGROUND: We aimed to compare the clinical outcomes of clopidogrel, prasugrel, and ticagrelor in clinical practice using the National Cardiovascular Database ACTION Registry(®). Treatment guidelines for patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention recommend dual antiplatelet therapy (DAPT) for 12 months. Few clinical trials have compared the safety and efficacy of clopidogrel with that of newer antiplatelet therapies. METHODS: A retrospective study of patients hospitalized for ACS at Cleveland Clinic Akron General was conducted...
June 2017: Cardiology Research
https://www.readbyqxmd.com/read/28725260/help-seeking-and-suicidality-among-people-with-epilepsy-in-a-rural-low-income-country-setting-cross-sectional-survey
#13
Ruth Tsigebrhan, Charlotte Hanlon, Girmay Medhin, Abebaw Fekadu
BACKGROUNDS: Epilepsy is a serious neurological disorder associated with a high level of psychiatric comorbidity. Suicidality is a recognised complication of epilepsy. As part of developing an integrated service for people with epilepsy (PWE) and priority psychiatric disorders within primary care, a cross-sectional study was conducted in a rural district in Ethiopia to investigate patterns of help-seeking, suicidality and the association with duration of untreated epilepsy (DUE) among PWE...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28724447/blood-donation-practice-and-its-associated-factors-among-health-professionals-of-university-of-gondar-hospital-northwest-ethiopia-a-cross-sectional-study
#14
Getachew Arage, Seada Ibrahim, Endeshaw Adimasu
BACKGROUND: Blood donation has remained a challenge in developing countries, like Ethiopia. In Ethiopia there is a high reliance on family surrogate and waged blood donors which carries an attendant increased risk of transfusion transmissible infection. Health workers are expected to practice blood donation so as to create a good image to the public. A study on blood donation behavior may improve successful implementation of the blood donation programs. METHODS: An institution based cross-sectional study was deployed from January to June 2015...
July 19, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28724246/health-consequences-of-electric-lighting-practices-in-the-modern-world-a-report-on-the-national-toxicology-program-s-workshop-on-shift-work-at-night-artificial-light-at-night-and-circadian-disruption
#15
REVIEW
Ruth M Lunn, David E Blask, Andrew N Coogan, Mariana G Figueiro, Michael R Gorman, Janet E Hall, Johnni Hansen, Randy J Nelson, Satchidananda Panda, Michael H Smolensky, Richard G Stevens, Fred W Turek, Roel Vermeulen, Tania Carreón, Claire C Caruso, Christina C Lawson, Kristina A Thayer, Michael J Twery, Andrew D Ewens, Sanford C Garner, Pamela J Schwingl, Windy A Boyd
The invention of electric light has facilitated a society in which people work, sleep, eat, and play at all hours of the 24-hour day. Although electric light clearly has benefited humankind, exposures to electric light, especially light at night (LAN), may disrupt sleep and biological processes controlled by endogenous circadian clocks, potentially resulting in adverse health outcomes. Many of the studies evaluating adverse health effects have been conducted among night- and rotating-shift workers, because this scenario gives rise to significant exposure to LAN...
July 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724014/prescription-medication-by-physiotherapists-a-brazilian-view-of-the-united-kingdom-canada-australia-and-new-zealand
#16
Valton da Silva Costa
Many health systems (HS) have adopted novel models of care which have included non-medical prescription (NMP) by physiotherapists. The aim of this study was to verify in the literature the existence of this practice and its possible benefits. A literature review was carried out through search on Science Direct, PubMed, SciELO, Lilacs and Google Scholar, and in the World Confederation for Physical Therapy and Chartered Society of Physiotherapy websites. In recent decades the United Kingdom adopted the NMP for health professionals, followed by Canada...
July 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28723820/the-effects-of-cardiovascular-fitness-and-body-composition-on-maximal-core-temperature-in-collegiate-football-players-during-pre-season
#17
JoAnna M McClelland, Sandra Fowkes Godek, Pamela S Chlad, Deborah L Feairheller, Katherine E Morrison
This study evaluated the effects of BMI and aerobic fitness (VO2max) on maximal core temperature values (Tcmax) in 17 NCAA Division III football players during pre-season. The subjects included nine backs (BKs) and eight linemen (LM). VO2max testing was performed one week prior to pre-season. Core temperature was monitored via ingestible sensor every 10 min during practices on day 4(D1), day 5(D2), day 7(D3), and post-acclimatization on day 14(D4). Wet bulb globe temperature (WBGT) was recorded on each collection day...
July 14, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28723499/prospective-evaluation-of-the-impact-of-antiangiogenic-treatment-on-cognitive-functions-in-metastatic-renal-cancer
#18
Florence Joly, Natacha Heutte, Brigitte Duclos, Sabine Noal, Isabelle Léger-Hardy, Sarah Dauchy, Nadine Longato, Laurence Desrues, Nadine Houede, Marie Lange, Emmanuel Sevin, Chantal Rieux, Bénédicte Clarisse, Hélène Castel, Bernard Escudier
BACKGROUND: Little is known about the cognitive effects of antiangiogenic therapies (AATs) in metastatic renal cell carcinoma (mRCC) and their relation with fatigue. OBJECTIVE: To evaluate the impact of AATs on cognition and its connection with fatigue and quality of life (QoL) in patients with mRCC. DESIGN, SETTING, AND PARTICIPANTS: This prospective study enrolled 75 patients starting AAT as first or second line for mRCC and assessed them at 3 mo (n=58) and 6 mo (n=50)...
December 15, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723264/patterns-of-care-and-outcomes-with-the-addition-of-chemotherapy-to-radiation-therapy-for-stage-i-nasopharyngeal-cancer
#19
Vivek Verma, Jeffrey M Ryckman, Charles B Simone, Chi Lin
PURPOSE: The standard of care for stage I (T1N0) nasopharyngeal cancer (NPC) is definitive radiotherapy (RT). Given the phase III evidence supporting combined chemoradiotherapy (CRT) for stage II NPC, we investigated practice patterns and outcomes associated with administration of chemotherapy to RT alone for stage I NPC. METHODS: The National Cancer Data Base (NCDB) was queried for clinical T1N0 primary NPC cases (2004-2013) receiving curative-intent RT. Patients with unknown RT/chemotherapy status were excluded, as were benign/sarcomatous histologies and receipt of pharyngectomy...
July 19, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28722646/noncongruence-between-audiologist-and-patient-preferences-for-patient-centeredness
#20
Vinaya Manchaiah, Ashley L Dockens, Monica Bellon-Harn, Erin S Burns
BACKGROUND: Trends in preferences of both healthcare providers and patients to patient-centeredness have been emphasized in research. However, an understanding of the nature of preferences to patient-centeredness within the context of the audiologist-patient relationship is needed. PURPOSE: The purpose of this study is to explore the congruence between audiologist and patient preferences for patient-centeredness. RESEARCH DESIGN: A cross-sectional survey design was used to gather data from audiologists and patients with hearing loss...
July 2017: Journal of the American Academy of Audiology
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