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https://www.readbyqxmd.com/read/29027825/cost-effectiveness-of-carfilzomib-plus-dexamethasone-compared-with-bortezomib-plus-dexamethasone-for-patients-with-relapsed-or-refractory-multiple-myeloma-in-the-united-states
#1
Andrzej J Jakubowiak, Ivan Houisse, István Májer, Ágnes Benedict, Marco Campioni, Sumeet Panjabi, Sikander Ailawadhi
BACKGROUND: We assessed the economic value of carfilzomib 56 mg/m(2) and dexamethasone (Kd56) vs bortezomib and dexamethasone (Vd) for relapsed/refractory multiple myeloma (R/RMM) using ENDEAVOR trial results. RESEARCH DESIGN AND METHODS: Cost-effectiveness of Kd56 vs Vd was assessed using a partitioned survival model by estimating progression-free survival, overall survival, and direct costs over a lifetime horizon. Surveillance Epidemiology and End Results (SEER) survival data were extrapolated after matching registry and ENDEAVOR patients...
October 13, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/29026791/willingness-to-pay-for-complementary-health-care-insurance-in-iran
#2
Shirin Nosratnejad, Arash Rashidian, Ali Akbari Sari, Najme Moradi
BACKGROUND: Complementary health insurance is increasingly used to remedy the limitations and shortcomings of the basic health insurance benefit packages. Hence, it is essential to gather reliable information about the amount of Willingness to Pay (WTP) for health insurance. We assessed the WTP for health insurance in Iran in order to suggest an affordable complementary health insurance. METHODS: The study sample consisted of 300 household heads all over provinces of Iran in 2013...
September 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28983400/human-papillomavirus-vaccination-uptake-in-canada-a-systematic-review-and-meta-analysis
#3
REVIEW
Yelena Bird, Olatunji Obidiya, Razi Mahmood, Chijioke Nwankwo, John Moraros
Human papillomavirus (HPV) is the most commonly sexually transmitted infection in the world and the primary cause of cervical cancer. Canada introduced publicly funded HPV vaccination programs in 2006. The objectives of this study are twofold and aim to (1) determine the levels and (2) examine the various factors influencing vaccine uptake among the general Canadian population. A literature search was conducted on seven databases, followed by screening, methodological quality review (using modified Newcastle-Ottawa Scale), and data extraction...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28982082/modification-and-quantification-of-in-vivo-erod-live-imaging-with-zebrafish-danio-rerio-embryos-to-detect-both-induction-and-inhibition-of-cyp1a
#4
Britta Kais, Richard Ottermanns, Franziska Scheller, Thomas Braunbeck
The visualization of specific activation of the aryl hydrocarbon receptor (AhR) directly in the zebrafish embryo (Danio rerio) via live-imaging is a reliable tool to investigate the presence of dioxin-like substances in environmental samples. The co-existence of inducers and inhibitors of cytochrome P450-dependent monooxygenases (CYP1A) is typical of complex environmental mixtures and requires modifications of the in vivo EROD assay: For this end, zebrafish embryos were used to evaluate the EROD-modifying potentials of common single-compound exposures as well as binary mixtures with the PAH-type Ah-receptor agonist β-naphthoflavone...
October 2, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28977692/ant-plant-mutualism-a-dietary-by-product-of-a-tropical-ant-s-macronutrient-requirements
#5
Lina M Arcila Hernández, Jon G Sanders, Gabriel A Miller, Alison Ravenscraft, Megan E Frederickson
Many arboreal ants depend on myrmecophytic plants for both food and shelter; in return, these ants defend their host plants against herbivores, which are often insects. Ant-plant and other mutualisms do not necessarily involve the exchange of costly rewards or services; they may instead result from by-product benefits, or positive outcomes that do not entail a cost for one or both partners. Here, we examined whether the plant-ant Allomerus octoarticulatus pays a short-term cost to defend their host plants against herbivores, or whether plant defense is a by-product benefit of ant foraging for insect prey...
October 4, 2017: Ecology
https://www.readbyqxmd.com/read/28976250/recommendations-from-the-first-national-academic-consortium-of-telehealth
#6
Judd E Hollander, Theresa M Davis, Charles Doarn, Jason C Goldwater, Stephen Klasko, Curtis Lowery, Dimitrios Papanagnou, Peter Rasmussen, Frank D Sites, Danica Stone, Brendan G Carr
In January 2015, the US Secretary of Health and Human Services announced targets for the transformation of Medicare reimbursement from a fee-for-service model to payments based on alternative payment models. People now use technology for virtually everything - from paying bills to purchasing almost anything; it is therefore natural to think that they will use technology to take ownership of their own health care. The remote provision of health care, where providers and patients are not in the same location, will allow patients to receive the right care, at the right time, at the right place, and in the manner they consider right for them...
October 4, 2017: Population Health Management
https://www.readbyqxmd.com/read/28971373/the-premarket-assessment-of-the-cost-effectiveness-of-a-predictive-technology-straticyte%C3%A2-for-the-early-detection-of-oral-cancer-a-decision-analytic-model
#7
S Khoudigian-Sinani, G Blackhouse, M Levine, L Thabane, D O'Reilly
INTRODUCTION: Approximately half of oral cancers are detected in advanced stages. The current gold standard is histopathological assessment of biopsied tissue, which is subjective and dependent on expertise. Straticyte™, a novel prognostic tool at the pre-market stage, that more accurately identifies patients at high risk for oral cancer than histopathology alone. This study conducts an early cost-effectiveness analysis (CEA) of Straticyte™ and histopathology versus histopathology alone for oral cancer diagnosis in adult patients...
October 2, 2017: Health Economics Review
https://www.readbyqxmd.com/read/28970102/the-proteome-speciation-of-an-immortalized-cystic-fibrosis-cell-line-new-perspectives-on-the-pathophysiology-of-the-disease
#8
Puglia Michele, Landi Claudia, Gagliardi Assunta, Breslin Loretta, Armini Alessandro, Brunetti Jlenia, Pini Alessandro, Bianchi Laura, Bini Luca
Cystic Fibrosis (CF) is a recessively inherited disease caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. CFTR has a pivotal role in the onset of CF, and several proteins are involved in its homeostasis. To study CFTR interactors at protein species level, we used a functional proteomics approach combining 2D-DIGE, mass spectrometry and enrichment analysis. A human bronchial epithelial cell line with cystic fibrosis (CFBE41o-) and the control (16HBE14o-) were used for the comparison...
September 29, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28964375/genotypic-variability-of-carotenoids-in-traditional-tomato-cultivars
#9
Pilar Flores, Elena Sánchez, José Fenoll, Pilar Hellín
Traditional varieties constitute a wide source of genetic variation that can be used per se or to obtain new cultivars with high consumer appeal and nutritional value. This work focuses on the carotenoid and chlorophyll profiles and contents of 53 traditional tomato cultivars, paying particular attention to compounds with recognized health-promoting properties. The study includes fruits with different shapes (oblate, slightly flattened, rounded, heart-shaped, long oblong and pyriform), colors (yellow, pink and red) and sizes (very small to very large)...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28954998/solitary-distant-peritoneal-metastasis-of-cecal-cancer-after-laparoscopic-colectomy-a-case-report
#10
Akira Ouchi, Koji Komori, Kenya Kimura, Takashi Kinoshita, Seiji Ito, Tetsuya Abe, Yoshiki Senda, Kazunari Misawa, Yuichi Ito, Norihisa Uemura, Seiji Natsume, Jiro Kawakami, Yasuhiro Shimizu
A 77-year-old Japanese female underwent laparoscopic ileocecal resection and lymph node dissection for cecal cancer by a previous doctor. Two years and 9 months after previous operation, contrast-enhanced computed tomography and magnetic resonance imaging with gadolinium ethoxybenzyl-L-diethylenetriamine pentaacetic acid revealed an intraperitoneal tumor at the right subphrenic fossa. 18F-fluorodeoxyglucose position emission tomography showed fluorodeoxyglucose accumulation in the tumor, and we suspected the tumor to be solitary distant peritoneal metastasis of the previous cecal cancer to the right diaphragm...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28953554/prognostic-value-of-resection-margin-involvement-after-pancreaticoduodenectomy-for-ductal-adenocarcinoma-updates-from-a-french-prospective-multicenter-study
#11
Jean Robert Delpero, Florence Jeune, Philippe Bachellier, Nicolas Regenet, Yves Patrice Le Treut, Francois Paye, Nicolas Carrere, Alain Sauvanet, Mustapha Adham, Aurelie Autret, Flora Poizat, Olivier Turrini, Jean Marie Boher
OBJECTIVE: The aim of the study was to assess the relevance of resection margin status for survival after resection of pancreatic-head ductal adenocarcinoma. SUMMARY BACKGROUND DATA: The definition and prognostic value of incomplete microscopic resection (R1) remain controversial. METHODS: Prognostic factors were analyzed in 147 patients included in a prospective multicenter study on the impact of tumor clearance evaluated using a standardized pathology protocol...
November 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28944730/optimization-of-medication-use-at-accountable-care-organizations
#12
Chrisanne Wilks, Erik Krisle, Kimberly Westrich, Kristina Lunner, David Muhlestein, Robert Dubois
BACKGROUND: Optimized medication use involves the effective use of medications for better outcomes, improved patient experience, and lower costs. Few studies systematically gather data on the actions accountable care organizations (ACOs) have taken to optimize medication use. OBJECTIVES: To (a) assess how ACOs optimize medication use; (b) establish an association between efforts to optimize medication use and achievement on financial and quality metrics; (c) identify organizational factors that correlate with optimized medication use; and (d) identify barriers to optimized medication use...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944511/cost-utility-analysis-of-direct-vad-versus-double-bridges-to-heart-transplantation-in-patients-with-refractory-heart-failure
#13
Hsiao-Huang Chang, Po-Lin Chen, I-Ming Chen, Tzu-Ting Kuo, Zen-Chung Weng, Pei-Jung Huang, Nai-Yuan Wu, Ching-Li Cheng
OBJECT: This study compared the cost-utility of direct ventricular assist device (VAD) versus double bridges, extracorporeal membrane oxygenation (ECMO) before VAD, to heart transplantation in patients with refractory heart failure. MATERIALS AND METHODS: From a health payer perspective, a Markov model was developed. The cycle length was one month and the time horizon was a lifetime. Probabilities and direct cost data were calculated from a nationwide claim database...
September 25, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28939346/asymmetric-public-goods-game-cooperation-through-pest-control
#14
T Reeves, H Ohtsuki, S Fukui
Cooperation in a public goods game has been studied extensively to find the conditions for sustaining the commons, yet the effect of asymmetry between agents has been explored very little. Here we study a game theoretic model of cooperation for pest control among farmers. In our simple model, each farmer has a paddy of the same size arranged adjacently on a line. A pest outbreak occurs at an abandoned paddy at one end of the line, directly threatening the frontier farmer adjacent to it. Each farmer pays a cost of his or her choice to an agricultural collective, and the total sum held by the collective is used for pest control, with success probability increasing with the sum...
December 21, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28929048/brand-versus-generic-dispensing-trend-for-ciprofloxacin-500-mg-levofloxacin-500-mg-and-moxifloxacin-400-mg-oral-dosage-forms-among-pharmacies-of-karachi-pakistan
#15
Fatima Zehra, Atta Abbas Naqvi, Sumbul Tasneem, Rizwan Ahmad, Niyaz Ahmad, Adnan Zia Shamsi, Naqiya Ali Asghar, Ghufran Ullah Khan
INTRODUCTION: Pakistan spends 0.7% of its gross domestic product on health. The public sector health-care system provides services to 22% of population thus paving the way for a dominant private sector. Patients in Pakistan mostly pay their medical expenses directly, and 64% of the health expenditures are borne by the household. Expenditure on medicine constitutes 43% of the total household expenditure. METHODS: A quantitative cross-sectional study was conducted in Karachi, Pakistan, for a month...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28926026/conceptual-models-underlying-economic-analysis-of-animal-health-and-welfare-with-the-inclusion-of-three-components-people-products-and-resources
#16
D A Hennessy
Infectious animal diseases can spill across farm boundaries, so effective management requires coordinated responses. Costs and benefits from the management of infectious diseases are such that those who make the decisions have weak incentives to act, the levels of goods and services produced from animal agriculture are probably smaller than is socially optimal and resources are likely wasted. This work provides an overview of the existing literature on conceptual economic models in animal disease management, paying particular attention to inadequate incentives to make the required biosecurity efforts...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28923479/neural-representation-of-cost-benefit-selections-in-medial-prefrontal-cortex-of-rats
#17
Hua Tang, Xuan Sun, Bao-Ming Li, Fei Luo
Decision making refers to the process that subjects use to choose between competing courses of action based on the expected costs and benefits of their consequences. However, few studies have addressed the neuronal mechanisms behind the processes of how costs and benefits influence decision making. Here we investigated the neuronal representation of costs and benefits towards a goal-directed action under a differential reward schedule by training rats to perform a "Do more, get more" (DM-GM) task utilizing a nosepoke operandum, where longer nosepoke durations resulted in correspondingly larger rewards...
September 18, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28922952/transitions-that-matter-life-course-differences-in-the-employment-of-adults-with-arthritis
#18
Arif Jetha, Julie Bowring, Sean Tucker, Catherine E Connelly, Kathleen A Martin Ginis, Laurie Proulx, Monique A M Gignac
PURPOSE: To understand the similarities and differences in the employment participation of people living with arthritis across the life course. METHOD: Focus groups and interviews were conducted with young (ages 18-34 years, n = 7), middle-aged (ages 35-54 years, n = 13) and older adults (>55 years, n = 25) with arthritis. Participants were asked about the impact of arthritis on employment, experiences with health-related changes, career progression and social role involvement...
September 18, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28906599/dual-extrusion-3d-printing-of-anatomical-models-for-education
#19
Michelle L Smith, James F X Jones
Two material 3D printing is becoming increasingly popular, inexpensive and accessible. In this paper, freely available printable files and dual extrusion fused deposition modelling were combined to create a number of functional anatomical models. To represent muscle and bone FilaFlex(3D) flexible filament and polylactic acid (PLA) filament were extruded respectively via a single 0.4 mm nozzle using a Big Builder printer. For each filament, cubes (5 mm(3) ) were printed and analyzed for X, Y, and Z accuracy...
September 14, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28905669/correction-notice
#20
(no author information available yet)
Agee, M. D., & Gates, Z. (2014). The Impact of an Insurance Administration-Free Primary Care Office on Hospital Admissions: A Community-Level Comparison With Traditional Fee-for-Service Family Practice Groups. Journal of Primary Care & Community Health, 5, 202-207. doi: 10.1177/2150131914522123 The following Conflict of Interest statement was originally omitted and will be added to the article: Author Zane Gates's affiliation, UPMC Altoona, is the parent organization of Partnering for Health Services. Additionally, author Zane Gates has an ownership interest in the Empower(3) Center for Health, a direct-pay primary care clinic using a subscription coverage model, that additionally provides insurance counseling and prescription programs...
September 1, 2017: Journal of Primary Care & Community Health
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