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https://www.readbyqxmd.com/read/29230173/blueberry-phenolics-reduce-gastrointestinal-infection-of-patients-with-cerebral-venous-thrombosis-by-improving-depressant-induced-autoimmune-disorder-via-mir-155-mediated-brain-derived-neurotrophic-factor
#1
Ning Xu, Hao Meng, Tianyi Liu, Yingli Feng, Yuan Qi, Donghuan Zhang, Honglei Wang
Cerebral venous thrombosis (CVT) often causes human depression, whereas depression-induced low immunity makes the patients susceptible to gastrointestinal infection. Blueberry possesses antidepressant properties which may improve autoimmunity and reduce gastrointestinal infection. Brain-derived neurotrophic factor (BDNF) performs antidepressant function and can be regulated by miR-155, which may be affected by blueberry. To explore the possible molecular mechanism, blueberry compounds were analyzed by high-performance liquid chromatography...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29228569/the-effects-of-blueberry-anthocyanins-on-histone-acetylation-in-rat-liver-fibrosis
#2
Wei Zhan, Xin Liao, Ru-Jia Xie, Tian Tian, Lei Yu, Xing Liu, Jing Liu, Po Li, Bing Han, Ting Yang, Bei Zhang, Li-Jun Cai, Rui Li, Qin Yang
To determine the effects ofanthocyanins from blueberries on hepatic stellate cell (HSCs-T6) and on histone acetylation during liver fibrosis induced by CCl4 in rats. Fifty male SD rats weighing 180 ± 20g were randomly placed into a control group, a hepatic fibrosis group, a blueberry treatment group, a blueberry intervention group, and a natural recovery group. After the rats were sacrificed, the livers and the liver indexes were measured, and the pathological changes were observed by HE staining and Masson staining...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227497/dietary-fruits-and-arthritis
#3
REVIEW
Arpita Basu, Jace Schell, R Hal Scofield
Arthritis is a global health concern affecting a significant proportion of the population and associated with reduced quality of life. Among the different forms of arthritis, osteoarthritis (OA) and rheumatoid arthritis (RA) are the most common and lacking a definite cure in the affected individuals. Fruits, such as berries and pomegranates are rich sources of a variety of dietary bioactive compounds, especially the polyphenolic flavonoids that have been associated with antioxidant, anti-inflammatory and analgesic effects...
December 11, 2017: Food & Function
https://www.readbyqxmd.com/read/29210129/effect-of-resveratrol-and-pterostilbene-on-aging-and-longevity
#4
REVIEW
Yi-Rong Li, Shiming Li, Chi-Chien Lin
Over the past years, several studies have found that foods rich in polyphenols protect against age-related disease, such as atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes (T2D), hypertension and Alzheimer's disease. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as anti-aging compounds through modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence...
December 6, 2017: BioFactors
https://www.readbyqxmd.com/read/29202339/heat-denatured-lysozyme-could-be-a-novel-disinfectant-for-reducing-hepatitis-a-virus-and-murine-norovirus-on-berry-fruit
#5
Michiko Takahashi, Yumiko Okakura, Hajime Takahashi, Minami Imamura, Akira Takeuchi, Hiroyuki Shidara, Takashi Kuda, Bon Kimura
Hepatitis A virus (HAV) is well known worldwide as a causative virus of acute hepatitis. In recent years, numerous cases of HAV infection caused by HAV-contaminated berries have occurred around the world. Because berries are often consumed without prior heating, reliable disinfection of the raw fruit is important in order to prevent HAV outbreaks. Previous studies have found that murine norovirus strain 1 (MNV-1) and human norovirus GII.4 were inactivated in heat-denatured lysozyme solution. In this study, we investigated whether or not heat-denatured lysozyme is effective in inactivating HAV and whether it could be an effective disinfectant for berries contaminated with HAV or MNV-1...
November 24, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29196236/berries-containing-anthocyanins-with-enhanced-methylation-profiles-are-more-effective-at-ameliorating-high-fat-diet-induced-metabolic-damage
#6
Emily Skates, John Overall, Katelyn Dezego, Mickey Wilson, Debora Esposito, Mary Ann Lila, Slavko Komarnytsky
Driven by the need for alternative whole food options to manage metabolic syndrome, multiple dietary interventions are suggested to achieve a better control of metabolic risk factors and molecular networks that regulate cellular energy metabolism. It is generally accepted that anthocyanin-rich diets are beneficial for maintaining healthy body weight, improving glucose and lipid metabolism, and determining inflammatory status of key metabolic tissues. However, anthocyanins are a structurally diverse group of phenolic compounds and their individual contributions to improving metabolic health are not clear...
November 28, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29184669/repeat-dose-nrpt-nicotinamide-riboside-and-pterostilbene-increases-nad-levels-in-humans-safely-and-sustainably-a-randomized-double-blind-placebo-controlled-study
#7
Ryan W Dellinger, Santiago Roel Santos, Mark Morris, Mal Evans, Dan Alminana, Leonard Guarente, Eric Marcotulli
NRPT is a combination of nicotinamide riboside (NR), a nicotinamide adenine dinucleotide (NAD+) precursor vitamin found in milk, and pterostilbene (PT), a polyphenol found in blueberries. Here, we report this first-in-humans clinical trial designed to assess the safety and efficacy of a repeat dose of NRPT (commercially known as Basis). NRPT was evaluated in a randomized, double-blind, and placebo-controlled study in a population of 120 healthy adults between the ages of 60 and 80 years. The study consisted of three treatment arms: placebo, recommended dose of NRPT (NRPT 1X), and double dose of NRPT (NRPT 2X)...
2017: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/29166540/statistical-optimization-of-an-rp-hplc-method-for-the-determination-of-selected-flavonoids-in-berry-juices-and-evaluation-of-their-antioxidant-activities
#8
Andrija Ciric, Milena Jelikic-Stankov, Milica Cvijovic, Predrag Djurdjevic
An isocratic RP-HPLC method for the separation and identification of selected flavonoids (quercetin, rutin, luteolin-7-O-glucoside, kaempferol, and kaempferol-3-O-glucoside) in commercial berries juices (blackcurrant, blueberry, red raspberry and cherry) was developed with the aid of central composite design and response surface methodology. The optimal separation conditions were a mobile phase of 85:15 (% v/v) water/acetonitrile, pH of 2.8 (adjusted with formic acid), flow rate 0.5 mL/min and column temperature of 35 °C...
November 22, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29155570/chemistry-antimicrobial-mechanisms-and-antibiotic-activities-of-cinnamaldehyde-against-pathogenic-bacteria-in-animal-feeds-and-human-foods
#9
Mendel Friedman
Cinnamaldehyde is a major constituent of cinnamon essential oils produced by aromatic cinnamon plants. This compound has been reported to exhibit antimicrobial properties in vitro in laboratory media and in animal feeds and human foods contaminated with disease-causing bacteria including Bacillus cereus, Campylobacter jejuni, Clostridium perfringens, Escherichia coli, Listeria monocytogenes, and Salmonella enterica. This integrated review surveys and interprets our current knowledge of the chemistry, analysis, safety, mechanism of action, and antibiotic activities of cinnamaldehyde in food animal (cattle, lambs, calves, pigs, poultry) diets and in widely consumed liquid (apple, carrot, tomato, and watermelon juices, milk) and solid foods...
December 6, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29152239/effects-of-dietary-supplementation-with-a-mixed-blueberry-and-grape-extract-on-working-memory-in-aged-beagle-dogs
#10
V Fragua, A Lepoudère, V Leray, C Baron, J A Araujo, P Nguyen, N W Milgram
Cellular oxidative damage is thought to be one of the key mechanisms underlying age-related cognitive impairment in dogs. Several nutritional interventions to limit cognitive decline are reported in the literature. To our knowledge, the association of grape and blueberry extracts has never been tested in aged dogs. Our objective was to evaluate the effect of a polyphenol-rich extract from grape and blueberry (PEGB) on oxidative status and cognitive performances in aged dogs. A total of thirty-five beagle dogs (aged 8·0-14·5 years) were fed a basal diet with PEGB at either 0 parts per million (ppm) (n 11; control), 240 ppm (n 12; PEGB1) or 480 ppm (n 12; PEGB2) for 75 d...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29144595/evaluation-of-405-nm-monochromatic-light-for-inactivation-of-tulane-virus-on-blueberry-surfaces
#11
David Kingsley, Rafael E Perez-Perez, Glenn Boyd, Joseph Sites, Brendan A Niemira
AIM: The study aim was to evaluate the potential of 405 nm light as a virus intervention for blueberries. METHODS AND RESULTS: Tulane virus-inoculated-blueberries were treated with 4.2 mW/sq cm of 405 nm light for 5 to 30 min. To mitigate thermal heating due to the intense light, a dry ice-chilled nitrogen-based cooling system was utilized. Blueberries were rotated to ensure exposure of all surfaces to 405 light. Five, 10, and 30 min treatments resulted in little or no inactivation of Tulane virus on blueberries (average log reductions of -0...
November 16, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29141966/nutritional-factors-affecting-adult-neurogenesis-and-cognitive-function
#12
REVIEW
Shibu M Poulose, Marshall G Miller, Tammy Scott, Barbara Shukitt-Hale
Adult neurogenesis, a complex process by which stem cells in the hippocampal brain region differentiate and proliferate into new neurons and other resident brain cells, is known to be affected by many intrinsic and extrinsic factors, including diet. Neurogenesis plays a critical role in neural plasticity, brain homeostasis, and maintenance in the central nervous system and is a crucial factor in preserving the cognitive function and repair of damaged brain cells affected by aging and brain disorders. Intrinsic factors such as aging, neuroinflammation, oxidative stress, and brain injury, as well as lifestyle factors such as high-fat and high-sugar diets and alcohol and opioid addiction, negatively affect adult neurogenesis...
November 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/29141041/effects-of-a-mixed-berry-beverage-on-cognitive-functions-and-cardiometabolic-risk-markers-a-randomized-cross-over-study-in-healthy-older-adults
#13
Anne Nilsson, Ilkka Salo, Merichel Plaza, Inger Björck
BACKGROUND: Berries and associated bioactive compounds, e.g. polyphenols and dietary fibre (DF), may have beneficial implications with respect to the metabolic syndrome, including also cognitive functions. The aim of this study was to evaluate effects on cognitive functions and cardiometabolic risk markers of 5 wk intervention with a mixture of berries, in healthy humans. METHODS: Forty healthy subjects between 50-70 years old were provided a berry beverage based on a mixture of berries (150g blueberries, 50g blackcurrant, 50g elderberry, 50g lingonberries, 50g strawberry, and 100g tomatoes) or a control beverage, daily during 5 weeks in a randomized crossover design...
2017: PloS One
https://www.readbyqxmd.com/read/29134464/phytochemical-properties-and-antioxidant-activities-of-extracts-from-wild-blueberries-and-lingonberries
#14
Paulina Dróżdż, Vaida Šėžienė, Krystyna Pyrzynska
Among Vaccinium species, blueberries (Vaccinium myrtillus L.) and lingonberries (Vaccinium vitis-idaea) are popular in the human diet. In this study, total phenolic, total flavonoid and total monomeric anthocyanin contents in the ethanol-water extracts of blueberry and lingonberry fruits grown wild in the forests in the central region of Poland were assayed. Antioxidant activities of the extracts from each plant were also evaluated for scavenging ability on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and reducing power by cupric reducing antioxidant capacity (CUPRAC) method...
November 14, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29125889/pterostilbene-down-regulates-htert-at-physiological-concentrations-in-breast-cancer-cells-potentially-through-the-inhibition-of-cmyc
#15
Michael Daniel, Trygve O Tollefsbol
Human telomerase reverse transcriptase (hTERT) encodes the catalytic subunit of telomerase, which has been shown to be upregulated in many cancers. Pterostilbene is a naturally occurring stilbenoid and phytoalexin found primarily in blueberries that exhibits antioxidant activity and inhibits the growth of various cancer cell types. Therefore, the aim of this study was to determine whether treatment with pterostilbene, at physiologically achievable concentrations, can inhibit the proliferation of breast cancer cells and down-regulate the expression of hTERT...
November 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29123512/alternative-growth-promoters-modulate-broiler-gut-microbiome-and-enhance-body-weight-gain
#16
Serajus Salaheen, Seon-Woo Kim, Bradd J Haley, Jo Ann S Van Kessel, Debabrata Biswas
Antibiotic growth promoters (AGPs) are frequently used to enhance weight-gain in poultry production. However, there has been increasing concern over the impact of AGP on the emergence of antibiotic resistance in zoonotic bacterial pathogens in the microbial community of the poultry gut. In this study, we adopted mass-spectrophotometric, phylogenetic, and shotgun-metagenomic approaches to evaluate bioactive phenolic extracts (BPE) from blueberry (Vaccinium corymbosum) and blackberry (Rubus fruticosus) pomaces as AGP alternatives in broilers...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29120800/abscisic-acid-stimulates-anthocyanin-accumulation-in-jersey-highbush-blueberry-fruits-during-ripening
#17
Hee Duk Oh, Duk Jun Yu, Sun Woo Chung, Sinath Chea, Hee Jae Lee
Non-climacteric blueberry (Vaccinium spp.) fruits accumulate high levels of anthocyanins during ripening, which are a good source of dietary antioxidants. This study examined the effects of exogenous abscisic acid (ABA) application on fruit characteristics and anthocyanin accumulation in a northern highbush blueberry (V. corymbosum 'Jersey') during development. Fruits on shrubs were treated with 1gL-1 ABA before the initiation of fruit colouration. Application of ABA temporarily increased the level of ABA in the fruits during development...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29115354/human-anthocyanin-bioavailability-effect-of-intake-duration-and-dosing
#18
Wilhelmina Kalt, Jane E McDonald, Melinda R Vinqvist-Tymchuk, Yan Liu, Sherry A E Fillmore
While in vitro and animal evidence supports a role for anthocyanins in human health, future opportunities in berry health benefits will rest upon evidence from clinical intervention trials. Because little is known about the behaviour of anthocyanins during long term intake in humans, several clinical design factors were examined. Urine from volunteers (n = 17) who consumed blueberry juice daily was analysed using LC-MS/MS for predicted flavonoid-based products of anthocyanins in relation to a 5-day anthocyanin-free run-in, 28 days of blueberry juice intake, a 7-day washout and two dosing regimens...
November 8, 2017: Food & Function
https://www.readbyqxmd.com/read/29108110/design-of-a-species-specific-pcr-method-for-the-detection-of-the-heat-resistant-fungi-talaromyces-macrosporus-and-talaromyces-trachyspermus
#19
Satoshi Yamashita, Hiroyuki Nakagawa, Toshifumi Sakaguchi, Toshi-Hide Arima, Yutaka Kikoku
Heat-resistant fungi occur sporadically and are a continuing problem for the food and beverage industry. The genus Talaromyces, as a typical fungus, is capable of producing the heat-resistant ascospores responsible for the spoilage of processed food products. Isocitrate lyase, a signature enzyme of the glyoxylate cycle, is required for the metabolism of non-fermentable carbon compounds, like acetate and ethanol. Here, species-specific primer sets for detection and identification of DNA derived from Talaromyces macrosporus and Talaromyces trachyspermus were designed based on the nucleotide sequences of their isocitrate lyase genes...
November 6, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29071487/-blueberry-muffin-rash-and-neonatal-cholestatic-liver-failure
#20
Kiran Mudambi, William Berquist
No abstract text is available yet for this article.
October 25, 2017: Digestive Diseases and Sciences
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