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JOURNAL ARTICLE
Lucia Parlati, Mehdi Sakka, Aurelia Retbi, Samir Bouam, Lamia Hassani, Jean-François Meritet, Pierre Rufat, Dominique Bonnefont-Rousselot, Rui Batista, Benoit Terris, Agnès Bellanger, Dominique Thabut, Aurore Vozy, Jean-Philippe Spano, Romain Coriat, François Goldwasser, Selim Aractingi, Philippe Sogni, Stanislas Pol, Vincent Mallet
BACKGROUND & AIMS: There is concern about the burden of liver injury in patients with cancer exposed to immune checkpoints inhibitors (ICIs). METHODS: In a retrospective cohort study, we evaluated the likelihood of grade 3/4 liver injury, of grade 3/4 cholestatic liver injury, and of liver failure, as per the Common Terminology Criteria for Adverse Events (CTCAE) version 5, following treatment with ICIs. We compared these occurrences with a group of cancer patients who were propensity-matched and treated with conventional chemotherapy...
December 2023: JHEP reports: innovation in hepatology
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JOURNAL ARTICLE
Ming Jiang, Mirjam C W Huizenga, Jonah L Wirt, Janos Paloczi, Avand Amedi, Richard J B H N van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F Driever, Bogdan I Florea, Uwe Grether, Antonius P A Janssen, Thomas Hankemeier, Laura H Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F Stevens, Daan van der Vliet, Tom van der Wel, Matthias B Wittwer, Constant A A van Boeckel, Pal Pacher, Andrea G Hohmann, Mario van der Stelt
Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical potential is limited by central nervous system (CNS)-mediated side effects. Here, we report the discovery of LEI-515, a peripherally restricted, reversible MAGL inhibitor, using high throughput screening and a medicinal chemistry programme. LEI-515 increased 2-AG levels in peripheral organs, but not mouse brain. LEI-515 attenuated liver necrosis, oxidative stress and inflammation in a CCl4 -induced acute liver injury model...
December 5, 2023: Nature Communications
#23
REVIEW
Ankush Jajodia, Philippe Soyer, Maxime Barat, Michael N Patlas
Hepato-pancreato-biliary (HPB) emergencies in patients with cancer encompass an extensive array of various conditions, including primary malignancies that require prompt treatment, associated severe complications, and life-threatening consequences arising from treatment. In patients with cancer, the liver can be affected by chemotherapy-induced hepatotoxicity, veno-occlusive disease, Budd-Chiari syndrome, liver hemorrhage, and other complications arising from cancer therapy with all these complications requiring timely diagnosis and prompt treament...
November 30, 2023: Diagnostic and Interventional Imaging
#24
JOURNAL ARTICLE
Mitchell R McGill, Yihong J Kaufman, Francesca V LoBianco, Mary A Schleiff, Nukhet Aykin-Burns, Grover P Miller
Tyrosine kinase inhibitors (TKIs) are increasingly popular drugs used to treat more than a dozen different diseases, including some forms of cancer. Despite having fewer adverse effects than traditional chemotherapies, they are not without risks. Liver injury is a particular concern. Of the FDA-approved TKIs, approximately 40% cause hepatotoxicity. However, little is known about the underlying pathophysiology. The leading hypothesis is that TKIs are converted by cytochrome P450 3A4 (CYP3A4) to reactive metabolites that damage proteins...
June 2023: Livers
#25
JOURNAL ARTICLE
Hannah Wiemers, Andreas Burchert, Christian Michel, Kristina Sohlbach, Jonas Schäfer, Andraes Neubauer, Christian Görg, Corinna Trenker
OBJECTIVE: A hypo-enhancement of the liver in contrast-enhanced ultrasound (CEUS), pathologic one-minute hepatic enhancement (pOMHE), was recently observed in 70% of allogeneic hematopoietic stem cell transplantation patients with a high-risk profile for veno-occlusive disease (VOD). Whether pOMHE was a pre-clinical sign of VOD or an unspecific feature of liver damage secondary to intensive chemotherapy is unclear. METHODS: To investigate this, we studied CEUS patterns in patients receiving high-dose chemotherapy prior to autologous hematopoietic stem cell transplantation (auto-HSCT) or intensive induction therapy (IT) for the treatment of acute leukemia...
November 13, 2023: Ultrasound in Medicine & Biology
#26
Bharat Patodiya, Vinod K Ramani, Padaki Nagaraja Rao, Mithun Sharma, Shalini Patodiya, D Nageshwar Reddy
In this report, we present the case of vanishing bile duct syndrome in the setting of classical Hodgkin lymphoma. Vanishing bile duct syndrome was diagnosed retrospectively in this patient with Hodgkin lymphoma, who initially presented with a hepatic abnormality presumed to be drug induced. Vanishing bile duct syndrome is characterized by the disappearance of bile ducts, with the progressive damage resulting in cholestasis. Thus, nivolumab therapy was initiated for Hodgkin lymphoma, in place of the standard ABVD (Doxorubicin, bleomycin, vinblastine, dacarbazine) regimen, which resulted in autoimmune hemolytic anemia...
2023: SAGE Open Medical Case Reports
#27
REVIEW
Ankitha Sivanand, Durva Talati, Yash Kalariya, Priyansh Patel, Siddharth Kamal Gandhi
Cholangiocarcinoma (CCa) is a highly lethal malignancy of biliary tract epithelial cells. Liver fluke infection is one of the well-known causes of CCa in endemic areas of Southeast Asian and Western Pacific regions. Multistep processes underlie carcinogenesis induced by chronic infection with the fish-borne liver fluke. Mechanical injury from fluke feeding and migrating in the bile duct causes damage to the bile duct epithelial cells. The excretory or secretory product of a parasite called OvGRN-1 is internalized by human cholangiocytes and induces changes in gene and protein expression associated with wound healing and cancer pathways...
October 2023: Curēus
#28
JOURNAL ARTICLE
Yasuhito Fujisaka, Takatoshi Nakagawa, Kiichiro Tomoda, Marina Watanabe, Ninso Matsunaga, Yosuke Tamura, Soichiro Ikeda, Akihisa Imagawa, Michio Asahi
Gefitinib is a key drug used in the treatment of non-small cell lung cancer (NSCLC) with EGFR mutations. Gefitinib therapy is superior to conventional chemotherapy for the progression-free survival rate of patients with EGFR mutations. However, 10-26% of patients develop grade 3 or higher hepatotoxicity during gefitinib treatment; therefore, the development of preclinical tests for hepatotoxicity prior to clinical use is desirable. The present study evaluated the use of induced pluripotent stem cells (iPSCs) and iPSC-derived hepatocytes (iPSC-heps), as a platform for preclinical test development...
December 2023: Oncology Letters
#29
Francesco Baldo, Enrico Drago, Daniela Nisticò, Silvia Buratti, Michaela Calvillo, Concetta Micalizzi, Maria Cristina Schiaffino, Mohamad Maghnie
Lactic acidosis is characterized by an excessive production of lactic acid or by its impaired clearance. Thiamine deficiency is an uncommon cause of lactic acidosis, especially in countries where malnutrition is rare. We describe the case of a 5-year-old boy who presented with a central nervous system relapse of acute lymphoblastic leukemia. During the chemotherapy regimen, the patient developed drug-induced pancreatitis with paralytic ileus requiring prolonged glucosaline solution infusion. In the following days, severe lactic acidosis (pH 7...
September 26, 2023: Children
#30
REVIEW
Ki M Mak, Aditya C Shekhar
Polyenylphosphatidylcholine (PPC) is a purified polyunsaturated phosphatidylcholine extract of soybeans. This article updates PPC's beneficial effects on various forms of liver cell injury and other tissues in experimental research. PPC downregulates hepatocyte CYP2E1 expression and associated hepatotoxicity, as well as attenuates oxidative stress, apoptosis, lipoprotein oxidation and steatosis in alcoholic and nonalcoholic liver injury. PPC inhibits pro-inflammatory cytokine production, while stimulating anti-inflammatory cytokine secretion in ethanol or lipopolysaccharide-stimulated Kupffer cells/macrophages...
October 10, 2023: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
#31
JOURNAL ARTICLE
Role of ATP Binding Cassette Subfamily A Member 1 (ABCA1) in Chemoradiotherapy-induced Renal Injury.
A Ahmad, M Ali, R Levy, R Stone, A Pollack
PURPOSE/OBJECTIVE(S): Radiation therapy (RT) alone or combined with chemotherapy reduces cholesterol efflux and causes chronic kidney disease (CKD). There is no treatment for CKD except renal replacement strategies such as dialysis or transplantation. We hypothesize that cancer treatment-induced ABCA1 deficiency leads to dysregulation of cholesterol metabolism, making podocytes susceptible and cancerous cells resistant to treatment-induced injuries. MATERIALS/METHODS: To quantify the cell index of LNCaP, 786-0, and Podcytes were grown in an e-plate reader (Roche) for 24 h and then were treated with either enzalutamide (10µM) or sunitinib (1...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#32
JOURNAL ARTICLE
Nuttinee Inworn, Preeyapon Senavat, Nuttaphon Aleenajitpong, Mes Chingchaimaneesri, Teerada Siripoon, Saowanee Srirattanapong, Wikran Suragul, Nuttapong Ngamphaiboon
BACKGROUND: Preoperative chemotherapy increases resectability in borderline resectable colorectal liver metastasis (CRLM) patients who undergo curative liver surgery. Most clinical risk scores and other predictive factors for survival have been extensively studied in patients who undergo upfront liver surgery. However, predictive factors of CRLM patients who received preoperative chemotherapy remains controversial. METHODS: CRLM patients who received preoperative systemic therapy followed by curative liver surgery at our institution between 1/2012 and 12/2018 were included...
September 1, 2023: Asian Pacific Journal of Cancer Prevention: APJCP
#33
Laine Lyles, Reagan Farmer, Marwan Abougergi
Immune checkpoint inhibitors are becoming more commonly used for many forms of malignancy. With this class of medications being more heavily used, there has been an associated rise in medication-induced autoimmune hepatitis. This case involves a 35-year-old woman being treated with nivolumab/ipilimumab for renal cell carcinoma who developed a steroid-refractory autoimmune hepatitis.
September 2023: ACG Case Reports Journal
#34
REVIEW
Vicenç Ruiz de Porras, Mariona Figols, Albert Font, Eva Pardina
Despite significant advances in cancer therapeutics, chemotherapy remains the cornerstone of treatment for many tumors. Importantly, however, chemotherapy-induced toxicity, including hepatotoxicity, can lead to the interruption or discontinuation of potentially effective therapy. In recent years, special attention has been paid to the search for complementary therapies to mitigate chemotherapy-induced toxicity. Although there is currently a lack of specific interventions to mitigate or prevent hepatotoxicity in chemotherapy-treated patients, the polyphenol compound curcumin has emerged as a potential strategy to overcome this adverse effect...
September 21, 2023: Life Sciences
#35
Lucas J Handlin, Natalie L Macchi, Nicolas Dumaire, Lyuba Salih, Kyle S McCommis, Aubin Moutal, Gucan Dai
Cell membranes consist of heterogeneous lipid domains that influence key cellular processes, including signal transduction, endocytosis, and electrical excitability. The goal of this study was to assess the size of cholesterol-enriched ordered membrane domains (OMD) in various cell types. Multiple cell types were tested using fluorescence lifetime imaging microscopy (FLIM) and Förster resonance energy transfer (FRET), whereby small nociceptor DRG neurons and cardiac pacemaker cells displayed the highest FRET intensities...
September 6, 2023: bioRxiv
#36
JOURNAL ARTICLE
Qiaoyan Liu, Bo Song, Sen Tong, Qiuqiong Yang, Huanhuan Zhao, Jia Guo, Xuexia Tian, Renjie Chang, Junzi Wu
Tumor is a serious threat to human health, with extremely high morbidity and mortality rates. However, tumor treatment is challenging, and the development of antitumor drugs has always been a significant research focus. Plant polysaccharides are known to possess various biological activities. They have many pharmacological properties such as immunomodulation, antitumor, antiviral, antioxidative, antithrombotic, and antiradiation effects, reduction of blood pressure and blood sugar levels, and protection from liver injury...
September 15, 2023: Recent Patents on Anti-cancer Drug Discovery
#37
JOURNAL ARTICLE
Pengzhen Niu, Wenyu Zhao, Qiong Wang, Junzhao Duan, Jie Zhu, Hanjiang Fu, Yongge Wu, Xiaofei Zheng, Daguang Zhang, Changhui Ge
BACKGROUND/AIM: CBLB502, a Toll-like receptor-5 agonist derived from Salmonella flagellin, exerts protective roles against irradiation and chemical drugs in mammalian tissues and stimulates tissue regeneration. This study aimed to investigate whether CBLB502 can protect against liver and kidney damage induced by the chemotherapeutic drug cisplatin (CDDP) and the underlying mechanism of the protective effect. MATERIALS AND METHODS: Mice were pretreated with CBLB502 [0...
2023: In Vivo
#38
JOURNAL ARTICLE
Carlos Fernández Moro, Natalie Geyer, Sara Harrizi, Yousra Hamidi, Sara Söderqvist, Danyil Kuznyecov, Evelina Tidholm Qvist, Media Salmonson Schaad, Laura Hermann, Amanda Lindberg, Rainer L Heuchel, Alfonso Martín-Bernabé, Soniya Dhanjal, Anna C Navis, Christina Villard, Andrea C Del Valle, Lorand Bozóky, Ernesto Sparrelid, Luc Dirix, Carina Strell, Arne Östman, Bernhard Schmierer, Peter B Vermeulen, Jennie Engstrand, Béla Bozóky, Marco Gerling
A perimetastatic capsule is a strong positive prognostic factor in liver metastases, but its origin remains unclear. Here, we systematically quantify the capsule's extent and cellular composition in 263 patients with colorectal cancer liver metastases to investigate its clinical significance and origin. We show that survival improves proportionally with increasing encapsulation and decreasing tumor-hepatocyte contact. Immunostaining reveals the gradual zonation of the capsule, transitioning from benign-like NGFRhigh stroma at the liver edge to FAPhigh stroma towards the tumor...
August 18, 2023: Nature Communications
#39
JOURNAL ARTICLE
Florian Primavesi, Manuel Maglione, Federica Cipriani, Timm Denecke, Christian E Oberkofler, Patrick Starlinger, Bobby V M Dasari, Jan Heil, Olivia Sgarbura, Kjetil Søreide, Rafael Diaz-Nieto, Constantino Fondevila, Adam E Frampton, Dominik Geisel, Benjamin Henninger, Amelia J Hessheimer, Mickaël Lesurtel, Damian Mole, Robert Öllinger, Pim Olthof, Thomas Reiberger, Andreas A Schnitzbauer, Christoph Schwarz, Ernesto Sparrelid, Martin Stockmann, Stéphanie Truant, Luca Aldrighetti, Eva Braunwarth, Mathieu D'Hondt, Michelle L DeOliveira, Joris Erdmann, David Fuks, Thomas Gruenberger, Klaus Kaczirek, Hassan Malik, Dietmar Öfner, Nuh N Rahbari, Georg Göbel, Ajith K Siriwardena, Stefan Stättner
BACKGROUND: Posthepatectomy liver failure (PHLF) contributes significantly to morbidity and mortality after liver surgery. Standardized assessment of preoperative liver function is crucial to identify patients at risk. These European consensus guidelines provide guidance for preoperative patient assessment. METHODS: A modified Delphi approach was used to achieve consensus. The expert panel consisted of hepatobiliary surgeons, radiologists, nuclear medicine specialists, and hepatologists...
August 12, 2023: British Journal of Surgery
#40
JOURNAL ARTICLE
Yue Zhang, Christopher Costin
A middle-childhood aged girl with recently diagnosed MDA5+ juvenile dermatomyositis complicated by interstitial lung disease presented with diffuse abdominal pain and scleral icterus following the initiation of cyclophosphamide therapy. A laboratory workup revealed elevated liver enzymes and hyperbilirubinaemia. She was admitted for worsening liver function, and all medications were held with concern for drug-induced liver injury. A workup for infectious and autoimmune causes of transaminitis was negative. A liver biopsy revealed diffuse apoptotic cells without evidence of portal obstruction...
August 9, 2023: BMJ Case Reports
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