keyword
https://read.qxmd.com/read/38487523/complete-remission-of-advanced-pancreatic-cancer-induced-by-claudin18-2-targeted-car-t-cell-therapy-a-case-report
#1
Guocheng Zhong, Xiaomin Zhang, Zheng Guo, Yujie Gao, Bochen Zhao, Xianhao Liu, Lei Chen, Jingqiao Qiao, Chuan Yu, Lixin Wang, Yisheng Li, Li Yu
Pancreatic cancer (PC) is one of the most malignant tumors in digestive system due to its highly invasive and metastatic properties. At present, conventional treatment strategies for PC show the limited clinical efficacy. Therefore, novel effective therapeutic strategies are urgently needed. Here, we report a case of complete remission of advanced PC induced by claudin18.2-targeted CAR-T cell therapy. The patient was a 72-year-old man who was diagnosed with pancreatic ductal adenocarcinoma 2 years ago, and he experienced tumor recurrence and multiple metastases after pancreaticoduodenectomy and multi-line chemotherapies, including liver, peritoneum, and cervical lymph node metastases...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38458274/the-combination-of-brassica-rapa-l-polysaccharides-and-cisplatin-enhances-the-anti-liver-cancer-effect-and-improves-intestinal-microbiota-and-metabolic-disorders
#2
JOURNAL ARTICLE
Hanrui Kong, Jun Yang, Xiaojing Wang, Nuramina Mamat, Guoxuan Xie, Jing Zhang, Huixin Zhao, Jinyu Li
Polysaccharides are commonly used as low-toxicity anticancer active substances to enhance the chemotherapeutic effect of cisplatin and reduce toxicity. Brassica rapa L. polysaccharides have been shown to have hepatoprotective effects; however, their anticancer effects in combination with cisplatin and their mechanisms have not been reported. An acidic polysaccharide from Brassica rapa L. (BRCPe) using hydroalcohol precipitation-assisted sonication was Characterized. The effects of BRCPe combined with cisplatin treatment on tumor growth in hepatocellular carcinoma mouse model were investigated...
March 6, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38400666/prediction-for-oxaliplatin-induced-liver-injury-using-patient-derived-liver-organoids
#3
JOURNAL ARTICLE
Kumiko Tatsumi, Hiroshi Wada, Shinichiro Hasegawa, Kei Asukai, Shigenori Nagata, Tomoya Ekawa, Takashi Akazawa, Yu Mizote, Shintaro Okumura, Ryosuke Okamura, Masayuki Ohue, Kazutaka Obama, Hideaki Tahara
BACKGROUND: Liver injury associated with oxaliplatin (L-OHP)-based chemotherapy can significantly impact the treatment outcomes of patients with colorectal cancer liver metastases, especially when combined with surgery. To date, no definitive biomarker that can predict the risk of liver injury has been identified. This study aimed to investigate whether organoids can be used as tools to predict the risk of liver injury. METHODS: We examined the relationship between the clinical signs of L-OHP-induced liver injury and the responses of patient-derived liver organoids in vitro...
February 2024: Cancer Medicine
https://read.qxmd.com/read/38374827/the-protective-effect-of-roflumilast-against-acute-hepatotoxicity-caused-by-methotrexate-in-wistar-rats-in-vivo-evaluation
#4
JOURNAL ARTICLE
Riyadh S Almalki
INTRODUCTION: Methotrexate (MTX) is one of the most widely used drugs in cancer chemotherapy and treating rheumatoid arthritis. The hepatotoxicity of MTX is one of its major side effects. Roflumilast (ROF) has been recognized to have antioxidant and anti-inflammatory activity in in-vivo and in-vitro models. The present study aimed to explore the potential protective effects of roflumilast against MTX-induced liver toxicity in male Wistar rats. METHODS: High dose of 5 mg/kg for 4 consecutive days subcutaneous (S...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38340708/hbv-reactivation-and-clinical-resolution-in-an-isolated-anti-hbc-positive-patient-during-immune-checkpoint-inhibition
#5
JOURNAL ARTICLE
Lukas S Baumert, Angela R Shih, Raymond T Chung
BACKGROUND: Immune checkpoint inhibitor (ICI)-related liver injury is a growing concern as ICIs are increasingly used in cancer treatment regimens. Interestingly, ICIs have exhibited antiviral effects among patients with chronic hepatitis B virus (HBV). However, the underlying mechanisms remain unclear, and clinical data on patients with previous HBV infection/exposure and isolated anti-HBV core antibodies (IAHBcs) are lacking. METHODS: We report a case illustrating the dual effects of ICIs in a patient experiencing panlobular hepatitis and concurrent HBV reactivation...
February 9, 2024: Med
https://read.qxmd.com/read/38297994/incidence-of-amoxycillin-clavulanic-acid-associated-hepatotoxicity-in-an-australian-children-s-hospital
#6
JOURNAL ARTICLE
Jessica A Eldredge, Laure F Pittet, Amanda Gwee
OBJECTIVES: Amoxycillin/clavulanic acid is the most common antimicrobial cause of drug-induced liver injury in adults. It is a less common cause of severe drug-related hepatotoxicity in children despite its frequent use. We studied the incidence, characteristics and predictive factors for amoxycillin/clavulanic acid hepatoxicity in children. DESIGN: Retrospective cohort study of children who received oral or intravenous amoxycillin/clavulanic acid at a quaternary children's hospital over a 5-year period...
March 1, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38287048/integrated-blood-and-organ-profile-analysis-to-evaluate-ameliorative-effects-of-kaempferol-on-5-fluorouracil-induced-toxicity
#7
JOURNAL ARTICLE
Abhilasha Sharma, Mehul R Chorawala, Rakesh M Rawal, Neeta Shrivastava
Colorectal cancer (CRC) treatment strategies encompass a triad of medical interventions: surgery, radiotherapy, and chemotherapy. Among these, the use of chemotherapy, specifically 5-fluorouracil (5-FU), has become a cornerstone in CRC management. However, it is imperative to explore novel approaches that harness the synergistic potential of chemotherapy agents alongside adjunctive compounds to mitigate the severe adverse effects that often accompany treatment. In light of this pressing need, this study focuses on evaluating Kaempferol (KMP) in combination with 5-FU in a DMH-induced CRC animal model, scrutinizing its impact on haematological indices, organ health, and gastrointestinal, hepatotoxic, and nephrotoxic effects...
January 29, 2024: Scientific Reports
https://read.qxmd.com/read/38251670/selection-of-galnac-conjugated-si-keap1-as-disease-specific-delivery-system-for-chemotherapy-induced-liver-injury-and-chronic-liver-disease
#8
JOURNAL ARTICLE
Mengmeng You, Meng Tian, Zhiling Song, Zhen Liu, Bingxue Yang, Shiyi Zhang
Chemotherapy-induced liver injury (CILI) is a pressing concern in cancer patients. One promising approach involves activating nuclear factor erythroid 2-related factor 2 (Nrf2) to mitigate CILI. However, selectively activating liver Nrf2 without compromising chemotherapy's efficacy has remained elusive. Herein, two RNAi delivery strategies were explored: lipid nanoparticle (LNP) and N -acetylgalactosamine (GalNAc) delivery systems loaded with siRNA designed to silence Kelch-like-ECH associated protein 1 (Keap1) by aiming for liver-specific Nrf2 activation...
January 31, 2024: Nano Letters
https://read.qxmd.com/read/38207276/the-hepatotoxicity-of-%C3%AE-radiation-synthesized-5-fluorouracil-nanogel-versus-5-fluorouracil-in-rats-model
#9
JOURNAL ARTICLE
Wael Em Barakat, Fatma Sm Moawed, Esraa Sa Ahmed, Omayma Ar Abo-Zaid
INTRODUCTION: The clinical use of 5-fluorouracil (5-FU), a routinely used chemotherapy medication, has a deleterious impact on the liver. Therefore, it is necessary to find a less harmful alternative to minimize liver damage. This study was designed to see how 5-fluorouracil nanogel influenced 5-FU-induced liver damage in rats. METHODS: To induce liver damage, male albino rats were injected intraperitoneally with 5-FU (12.5 mg/kg) three doses/week for 1 month...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38203593/altered-serum-alpha1-antitrypsin-protease-inhibition-before-and-after-clinical-hematopoietic-stem-cell-transplantation-association-with-risk-for-non-relapse-mortality
#10
JOURNAL ARTICLE
Ido Brami, Tsila Zuckerman, Ron Ram, Batia Avni, Galit Peretz, Daniel Ostrovsky, Yotam Lior, Caroline Faour, Oisin McElvaney, Noel G McElvaney, Eli C Lewis
α1-Antitrypsin (AAT), an acute-phase reactant not unsimilar to C-reactive protein (CRP), is a serine protease inhibitor that harbors tissue-protective and immunomodulatory attributes. Its concentrations appropriately increase during conditions of extensive tissue injury, and it induces immune tolerance, in part, by inhibiting the enzymatic activity of the inflammatory serine protease, proteinase 3 (PR3). Typically administered to patients with genetic AAT deficiency, AAT treatment was recently shown to improve outcomes in patients with steroid-refractory graft-versus-host disease (GVHD)...
December 28, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38202790/optimization-of-the-flavonoid-extraction-process-from-the-stem-and-leaves-of-epimedium-brevicornum-and-its-effects-on-cyclophosphamide-induced-renal-injury
#11
JOURNAL ARTICLE
Meiling Shi, Hongyan Pei, Li Sun, Weijia Chen, Ying Zong, Yan Zhao, Rui Du, Zhongmei He
Cyclophosphamide (CTX) is a broad-spectrum alkylated antitumor drug. It is clinically used in the treatment of a variety of cancers, and renal toxicity is one of the adverse reactions after long-term or repeated use, which not only limits the therapeutic effect of CTX, but also increases the probability of kidney lesions. The total flavonoids of Epimedium stem and leaf (EBF) and Icariin (ICA) are the main medicinal components of Epimedium, and ICA is one of the main active substances in EBF. Modern pharmacological studies have shown that EBF has a variety of biological activities such as improving osteoporosis, promoting cell proliferation, antioxidant and anti-inflammatory properties, etc...
December 29, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38184272/regulatory-network-of-ferroptosis-and-autophagy-by-targeting-oxidative-stress-defense-using-sulfasalazine-in-triple-negative-breast-cancer
#12
JOURNAL ARTICLE
Tomoka Takatani-Nakase, Chinami Ikushima, Manami Sakitani, Ikuhiko Nakase
AIMS: The cellular defense system against oxidative stress is important for the survival ability and sensitization in chemotherapy; however, the regulatory mechanisms remain unknown in triple-negative breast cancer (TNBC) cells. This study aimed to investigate the relationship between ferroptosis and autophagy by targeting the defense of oxidative stress through the cystine transporter (xCT) using sulfasalazine (SASP), which is a widely employed xCT inhibitor. MAIN METHODS: We analyzed the cell death process of SASP in human TNBC cells, and examined the effects of SASP on tumor progression by using xenograft mouse model...
January 4, 2024: Life Sciences
https://read.qxmd.com/read/38178678/micrornas-in-anticancer-drugs-hepatotoxicity-from-pathogenic-mechanism-and-early-diagnosis-to-therapeutic-targeting-by-natural-products
#13
JOURNAL ARTICLE
Hebatallah Husseini Atteia
Patients receiving cancer therapies experience severe adverse effects, including hepatotoxicity, even at therapeutic doses. Consequently, monitoring patients on cancer therapy for hepatic functioning is necessary to avoid permanent liver damage. Several pathways of anticancer drug-induced hepatotoxicity involve microRNAs (miRNAs) via targeting mRNAs. These short and non-coding RNAs undergo rapid modulation in non-targeted organs due to cancer therapy insults. Recently, there has been an interest for miRNAs as useful and promising biomarkers for monitoring toxicity since they have conserved sequences across species and are cellular-specific, stable, released during injury, and simple to analyze...
January 4, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38161559/a-case-of-l-asparaginase-induced-severe-hepatic-steatosis-with-decreased-serum-cholinesterase-levels
#14
Kazuhide Takata, Yuta Nakashima, Satoshi Shakado, Yasushi Takamatsu, Fumihito Hirai
L-asparaginase (L-Asp) is a useful antileukemic agent for acute lymphoblastic leukemia (ALL); however, it often causes severe liver injury with marked fatty liver. Here, we present a case of L-Asp-induced fatty liver disease in a 21-year-old female patient with ALL. Serum cholinesterase levels, which are usually elevated in fatty liver, decrease at the onset of liver injury. After treatment with L-carnitine and vitamin B complex, the liver injury rapidly improved, resulting in the patient being able to continue subsequent chemotherapy...
December 2023: Curēus
https://read.qxmd.com/read/38161498/predictive-model-of-oxaliplatin-induced-liver-injury-based-on-artificial-neural-network-and-logistic-regression
#15
JOURNAL ARTICLE
Rui Huang, Yuanxuan Cai, Yisheng He, Zaoqin Yu, Li Zhao, Tao Wang, Xiaofang Shangguan, Yuhang Zhao, Zherui Chen, Yunzhou Chen, Chengliang Zhang
BACKGROUND AND AIMS: Identifying potential high-risk groups of oxaliplatin-induced liver injury (OILI) is valuable, but tools are lacking. So artificial neural network (ANN) and logistic regression (LR) models will be developed to predict the risk of OILI. METHODS: The medical information of patients treated with oxaliplatin between May and November 2016 at 10 hospitals was collected prospectively. We used the updated Roussel Uclaf causality assessment method (RUCAM) to identify cases of OILI and summarized the patient and medication characteristics...
December 28, 2023: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38126610/effect-of-age-on-metabolomic-changes-in-a-model-of-paclitaxel-induced-peripheral-neurotoxicity
#16
JOURNAL ARTICLE
Roberta Bonomo, Annalisa Canta, Alessia Chiorazzi, Valentina Alda Carozzi, Cristina Meregalli, Eleonora Pozzi, Paola Alberti, Cecile F Frampas, Daan R Van der Veen, Paola Marmiroli, Debra J Skene, Guido Cavaletti
BACKGROUND AND AIMS: Chemotherapy-induced peripheral neurotoxicity (CIPN) is one of the most common dose-limiting side effects of paclitaxel (PTX) treatment. Many age-related changes have been hypothesized to underlie susceptibility to damage or impaired regeneration/repair after nerve injury. The results of these studies, however, are inconclusive and other potential biomarkers of nerve impairment need to be investigated. METHODS: Twenty-four young (2 months) and 24 adult (9 months) Wistar male rats were randomized to either PTX treatment (10 mg/kg i...
December 21, 2023: Journal of the Peripheral Nervous System: JPNS
https://read.qxmd.com/read/38124270/a-case-of-hepatitis-e-that-developed-during-chemotherapy-for-malignant-lymphoma-and-responded-to-ribavirin
#17
Seiya Hashimoto, Hirofumi Fukuda, Kohei Takeda, Keiichi Uchida, Fumiaki Sanuki, Takashi Akiyama, Eisei Kondo, Hideho Wada
BACKGROUND: The main differences in cases of sudden elevation of hepatic enzyme levels during immunochemotherapy are the reactivation of the hepatitis B virus or drug-induced liver injury. Here, we report a case of acute liver injury caused by the hepatitis E virus (HEV) during chemotherapy for malignant lymphoma, wherein the patient was successfully treated for the hepatitis and resumed chemotherapy to completion. CASE: A 57-year-old woman visited her local doctor because she felt lightweight and tired...
December 20, 2023: Cancer reports
https://read.qxmd.com/read/38104304/real-world-data-on-the-management-of-pazopanib-induced-liver-toxicity-in-routine-care-of-renal-cell-cancer-and-soft-tissue-sarcoma-patients
#18
JOURNAL ARTICLE
K Westerdijk, S D Krens, N Steeghs, W T A van der Graaf, E T T L Tjwa, H Westdorp, I M E Desar, N P van Erp
PURPOSE: Pazopanib is known to cause liver toxicity. A relationship between pazopanib exposure and alanine transaminase elevations has been described in clinical trials. This study investigated the relation between pazopanib exposure and liver toxicity in real-world patients and evaluated the management of pazopanib-induced liver toxicity in routine care. METHODS: A retrospective observational cohort study was performed in patients treated with pazopanib in whom pazopanib exposure was measured...
December 17, 2023: Cancer Chemotherapy and Pharmacology
https://read.qxmd.com/read/38077708/b-lymphoblastic-leukaemia-presenting-as-intrahepatic-cholestasis
#19
JOURNAL ARTICLE
Daniyal Raza, Maryam Mubashir, Karan Sachdeva, Lena Kawji, Ashley Deville, Syed Musa Raza, James Morris, Sudha Pandit
UNLABELLED: Acute cholangitis is a critical medical condition requiring prompt intervention. This case report explores the complexities and uncertainties encountered in clinical decision-making when faced with a patient presenting with symptoms suggestive of acute cholangitis. We emphasise the importance of considering individual circumstances and factors in the diagnostic process. A 38-year-old woman with a history of Crohn's colitis presented with abdominal pain, jaundice and leukocytosis...
2023: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/38074948/burden-of-grade-3-or-4-liver-injury-associated-with-immune-checkpoint-inhibitors
#20
JOURNAL ARTICLE
Lucia Parlati, Mehdi Sakka, Aurelia Retbi, Samir Bouam, Lamia Hassani, Jean-François Meritet, Pierre Rufat, Dominique Bonnefont-Rousselot, Rui Batista, Benoit Terris, Agnès Bellanger, Dominique Thabut, Aurore Vozy, Jean-Philippe Spano, Romain Coriat, François Goldwasser, Selim Aractingi, Philippe Sogni, Stanislas Pol, Vincent Mallet
BACKGROUND & AIMS: There is concern about the burden of liver injury in patients with cancer exposed to immune checkpoints inhibitors (ICIs). METHODS: In a retrospective cohort study, we evaluated the likelihood of grade 3/4 liver injury, of grade 3/4 cholestatic liver injury, and of liver failure, as per the Common Terminology Criteria for Adverse Events (CTCAE) version 5, following treatment with ICIs. We compared these occurrences with a group of cancer patients who were propensity-matched and treated with conventional chemotherapy...
December 2023: JHEP reports: innovation in hepatology
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