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chemotherapy induced liver injury

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https://www.readbyqxmd.com/read/28202860/hepatic-sinusoidal-obstruction-syndrome-induced-by-non-transplant-chemotherapy-for-non-hodgkin-lymphoma
#1
Miho Sakumura, Kazuto Tajiri, Shigeharu Miwa, Kohei Nagata, Kengo Kawai, Takayoshi Miyazono, Kotaro Arita, Akinori Wada, Jun Murakami, Toshiro Sugiyama
Hepatic sinusoidal obstruction syndrome (SOS), a serious complication that mainly occurs after hematopoietic-stem cell transplantation (HSCT), is caused by damage to the sinusoidal endothelial cells after the obstruction of the sinusoid. Recently, hepatic SOS was reported to occur after non-HSCT chemotherapies. This report describes a patient who experienced hepatic SOS after non-HSCT chemotherapy for non-Hodgkin lymphoma. A liver biopsy showed the slight dilatation of the hepatic sinusoid, which may be indicative of hepatic SOS...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28068634/virgin-coconut-oil-supplementation-attenuates-acute-chemotherapy-hepatotoxicity-induced-by-anticancer-drug-methotrexate-via-inhibition-of-oxidative-stress-in-rats
#2
Ademola C Famurewa, Odomero G Ufebe, Chima A Egedigwe, Onyebuchi E Nwankwo, Godwin S Obaje
BACKGROUND: The emerging health benefit of virgin coconut oil (VCO) has been associated with its potent natural antioxidants; however, the antioxidant and hepatoprotective effect of VCO against methotrexate-induced liver damage and oxidative stress remains unexplored. The study explored the antioxidant and hepatoprotective effects of VCO against oxidative stress and liver damage induced by anticancer drug methotrexate (MTX) in rats. METHODS: Liver damage was induced in Wistar rats pretreated with dietary supplementation of VCO (5% and 15%) by intraperitoneal administration of MTX (20mg/kg bw) on day 10 only...
January 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28061766/chemotherapy-induced-sinusoidal-injury-csi-score-a-novel-histologic-assessment-of-chemotherapy-related-hepatic-sinusoidal-injury-in-patients-with-colorectal-liver-metastasis
#3
Heather L Stevenson, Mariana M Prats, Eizaburo Sasatomi
BACKGROUND: Preoperative neoadjuvant therapy for colorectal liver metastases (CRLM) is increasing in use and can lead to chemotherapy-induced damage to sinusoidal integrity, namely sinusoidal obstruction syndrome (SOS). SOS has been associated with an increased need for intraoperative blood transfusions, increased length of hospitalization post-surgery, decreased tumor response, and a shorter overall survival after resection due to liver insufficiency. It is critical for clinicians and pathologists to be aware of this type of liver injury, and for pathologists to include the status of the background, non-neoplastic liver parenchyma in their pathology reports...
January 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/27995093/new-perspectives-in-the-treatment-of-colorectal-metastases
#4
REVIEW
Dominique Elias, Luca Viganò, Franco Orsi, Marta Scorsetti, Tiziana Comito, Jan Lerut, Davide Cosola, Guido Torzilli
BACKGROUND: In recent years, the management of metastatic colorectal cancer has become more aggressive and more multidisciplinary. New treatment options have been proposed in addition to the standard approach of resection of liver metastases and chemotherapy. SUMMARY: Selected patients with synchronous limited peritoneal and liver disease (peritoneal cancer index <12 and <3 liver metastases) can be scheduled for aggressive treatment, including cytoreductive surgery, hyperthermic intraperitoneal chemotherapy, and liver resection...
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27966724/the-protective-effects-of-cichorium-glandulosum-seed-and-cynarin-against-cyclophosphamide-and-its-metabolite-acrolein-induced-hepatotoxicity-in-vivo-and-in-vitro
#5
Jing Tong, Qi-Gui Mo, Bing-Xin Ma, Lan-Lan Ge, Gao Zhou, You-Wei Wang
Cyclophosphamide (CP) is a widely utilized chemotherapy drug. CP and its metabolite, acrolein, could induce hepatotoxicity. In this study, Cichorium glandulosum seed (CGS) effectively mitigated CP-induced hepatotoxicity in mice. Protection of cynarin, the major compound of CGS, against acrolein cytotoxicity in HepG2 cells was studied. Pretreatment with cynarin could improve cell survival against acrolein cytotoxicity. Cynarin restored the balance of glutathione (GSH) and reactive oxygen species (ROS), and inhibited mitochondrial depolarization...
December 14, 2016: Food & Function
https://www.readbyqxmd.com/read/27524882/paclitaxel-plus-valproic-acid-versus-paclitaxel-alone-as-second-or-third-line-therapy-for-advanced-gastric-cancer-a-randomized-phase-ii-trial
#6
Sachio Fushida, Jun Kinoshita, Masahide Kaji, Katsunobu Oyama, Yasuo Hirono, Tomoya Tsukada, Takashi Fujimura, Tetsuo Ohta
BACKGROUND: Weekly paclitaxel (wPTX) is the preferred second-line chemotherapy for gastric cancer in Japan. Histone deacetylase inhibitors have been shown to decrease proliferation through cell-cycle arrest, differentiation, and apoptosis in gastric cancer cells. One histone deacetylase inhibitor, valproic acid (VPA), also inhibits tumor growth by inducing apoptosis and enhances the efficacy of paclitaxel (PTX), shown in a murine gastric cancer model. This Phase II trial was designed to evaluate the benefits of adding VPA to wPTX in patients with gastric cancer refractory to first-line treatment with fluoropyrimidine...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27457977/chronic-preclinical-safety-evaluation-of-epo-018b-a-pegylated-peptidic-erythropoiesis-stimulating-agent-in-monkeys-and-rats
#7
Xue-Lian Gong, Xiao-Lei Gu, Yong-Chun Chen, Hai Zhu, Zhen-Na Xia, Jian-Zhong Li, Guo-Cai Lu
EPO-018B, a synthetic peptide-based erythropoiesis stimulating agent (ESA), is mainly designed for treatment of anemia caused by chronic renal failure and chemotherapy against cancer. It overcomes the deficiencies of currently approved ESA, including the frequent administration of temperature-sensitive recombinant protein and anti-EPO antibody-mediated pure red cell aplasia (PRCA). This study was designed to evaluate the potential chronic toxicity of EPO-018B. Subcutaneous administration doses were designed as 0, 0...
September 15, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27439417/fractal-dimension-of-tc-99m-dtpa-gsa-estimates-pathologic-liver-injury-due-to-chemotherapy-in-liver-cancer-patients
#8
Yukihiko Hiroshima, Kiyohiko Shuto, Kazuto Yamazaki, Daisuke Kawaguchi, Masatoshi Yamada, Yutaro Kikuchi, Kohei Kasahara, Takashi Murakami, Atsushi Hirano, Mikito Mori, Chihiro Kosugi, Kenichi Matsuo, Yasuo Ishida, Keiji Koda, Kuniya Tanaka
BACKGROUND: Chemotherapy-induced liver injury after potent chemotherapy is a considerable problem in patients undergoing liver resection. The aim of this study was to assess the relationship between the fractal dimension (FD) of Tc-99m diethylenetriaminepentaacetic acid (DTPA) galactosyl human serum albumin (GSA) and pathologic change of liver parenchyma in liver cancer patients who have undergone chemotherapy. METHODS: We examined 34 patients (10 female and 24 male; mean age, 68...
July 20, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27401445/parenchyma-sparing-hepatectomy-with-vascular-reconstruction-techniques-for-resection-of-colorectal-liver-metastases-with-major-vascular-invasion
#9
Saiho Ko, Yuuki Kirihataya, Masanori Matsusaka, Tomohide Mukogawa, Hirofumi Ishikawa, Akihiko Watanabe
BACKGROUND: Resectability of colorectal liver metastasis (CRLM) depends on major vascular involvement and is affected by chemotherapy-induced liver injury. Parenchyma-sparing with combined resection and reconstruction of involved vessels may expand the indications and safety of hepatectomy. METHODS: Of 92 patients who underwent hepatectomy for CRLM, 15 underwent major vascular resection and reconstruction. The reconstructed vessels were the portal vein (PV) in five cases, the major hepatic vein (HV) in nine cases, and the inferior vena cava in six cases...
August 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27073565/oxaliplatin-induced-sinusoidal-obstruction-syndrome-mimicking-metastatic-colon-cancer-in-the-liver
#10
Jung-Hye Choi, Young-Woong Won, Hyun Sung Kim, Young-Ha Oh, Sanghyeok Lim, Han-Joon Kim
Oxaliplatin is an effective chemotherapeutic agent for the treatment of colorectal cancer; however, it may cause liver injury, particularly sinusoidal obstruction syndrome (SOS). Although SOS does not usually present with focal lesions on radiological images, the present study describes the case of a 22-year-old woman with oxaliplatin-induced SOS mimicking metastatic colon cancer in the liver. An abdominal computed tomography revealed a novel 1 cm, low-density lesion in segment 1 of the liver following the administration of the fourth round of oxaliplatin-based adjuvant chemotherapy for stage III colon cancer...
April 2016: Oncology Letters
https://www.readbyqxmd.com/read/27049500/is-ursodeoxycholic-acid-detrimental-in-obstructive-cholestasis-a-propos-of-a-case-of-malignant-biliary-obstruction
#11
Fernando Bessone, Marcelo Gabriel Roma
Ursodeoxycholic acid (UDCA) is the first choice medication for most cholestatic hepatopathies, due to its capability to counteract inflammation and bile-acid-induced liver damage, two common features in cholestasis. However, UDCA is usually contraindicated in obstructive cholestasis, due to the alleged risk of biliary integrity disruption due to its choleretic effect. We report on an 83-year-old man with an unsuspected malignant biliary obstruction who received moderate doses of UDCA (8-12 mg/kg/day) for 5 weeks, because the preliminary evidence suggested he had chemotherapy-induced cholestasis...
May 2016: Annals of Hepatology
https://www.readbyqxmd.com/read/26972374/sinusoidal-dilation-increases-the-risk-of-complications-in-hepatectomy-for-crclm-protective-effect-of-bevacizumab-and-diabetes-mellitus-serum-gamma-glutamyltranspeptidase-as-predictive-factor
#12
J Martins, H Alexandrino, R Oliveira, M A Cipriano, D Falcão, L Ferreira, R Martins, M Serôdio, M Martins, J G Tralhão, L Prado e Castro, F Castro E Sousa
INTRODUCTION: Advances in neoadjuvant chemotherapy (NCT) have allowed surgical treatment in otherwise unresectable patients with colorectal liver metastases (CRLM). It is well known that NCT induces liver lesions such as sinusoidal obstruction syndrome (SOS) and steatohepatitis (SH). However, whether it affects postoperative morbidity remains controversial. The aim of this study was both to evaluate the impact of NCT on liver parenchyma and postoperative morbidity, and to identify preoperative predictive markers for liver injury...
May 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26935778/prevalence-risk-factors-management-and-treatment-outcomes-of-first-line-antituberculous-drug-induced-liver-injury-a-prospective-cohort-study
#13
Qin Sun, Qing Zhang, Jin Gu, Wen-Wen Sun, Peng Wang, Chong Bai, He-Ping Xiao, Wei Sha
PURPOSE: Antituberculosis drug-induced liver injury (ATDILI) is one of the most deleterious side effects associated with chemotherapy against tuberculosis (TB). In this study, our objective was to determine the incidence, risk factors, and management of ATDILI and analyze its impact on the treatment outcome in patients receiving standard anti-TB chemotherapy. METHODS: A prospective cohort study of ATDILI prevalence was conducted in 938 enrolled patients of the 1426 TB cases in Shanghai from March 2011 to September 2012...
August 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/26656265/melatonin-activates-endoplasmic-reticulum-stress-and-apoptosis-in-rats-with-diethylnitrosamine-induced-hepatocarcinogenesis
#14
Andrea Janz Moreira, Raquel Ordoñez, Carlos Thadeu Cerski, Jaqueline Nascimento Picada, Andrés García-Palomo, Norma Possa Marroni, Jose L Mauriz, Javier González-Gallego
Hepatocellular carcinoma (HCC) is one of the most lethal human cancers worldwide because of its high incidence, its metastatic potential and the low efficacy of conventional treatment. Inactivation of apoptosis is implicated in tumour progression and chemotherapy resistance, and has been linked to the presence of endoplasmic reticulum stress. Melatonin, the main product of the pineal gland, exerts anti-proliferative, pro-apoptotic and anti-angiogenic effects in HCC cells, but these effects still need to be confirmed in animal models...
2015: PloS One
https://www.readbyqxmd.com/read/26605100/a-rare-case-of-paclitaxel-and-or-trastuzumab-induced-acute-hepatic-necrosis
#15
Hiren Mandaliya, Pinky Baghi, Amy Prawira, Mathew K George
Paclitaxel induced mild derangement of liver functions including bilirubin, alkaline phosphatase, and AST has been infrequently noticed in clinical trials. Contrary to Paclitaxel, hepatocellular injury, hepatitis, and liver tenderness are common laboratory and clinical findings with Trastuzumab. However, hepatic failure/necrosis secondary to Paclitaxel or Trastuzumab has never been reported in literature. A 62-year-old lady, previously healthy, was treated with adjuvant therapy for left breast stage II, high grade invasive ductal carcinoma which was node negative, oestrogen receptor negative, progesterone receptor positive, and HER2 receptor positive...
2015: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/26435225/tetramethylpyrazine-identified-by-a-network-pharmacology-approach-ameliorates-methotrexate-induced-oxidative-organ-injury
#16
Bo Zhang, Cheng Lu, Ming Bai, Xiaojuan He, Yong Tan, Yanqin Bian, Cheng Xiao, Ge Zhang, Aiping Lu, Shao Li
ETHNOPHARMACOLOGICAL RELEVANCE: Tetramethylpyrazine (TMP) is one of the active constituents extracted from a frequently used herb, Ligusticum wallichii Franchat (Chuan-Xiong in Chinese), in traditional Chinese medicine. TMP can exert multiple pharmacological actions such as anti-inflammatory, anti-oxidative damage, anti-platelet and neuroprotective effects, and its applications deserve further explored. AIM OF THE STUDY: This study aimed to determine the new role of TMP identified by a network pharmacology approach to alleviate the methotrexate (MTX)-induced oxidative injury and characterize their mechanism of combinational actions...
December 4, 2015: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26344000/mechanistic-review-of-drug-induced-steatohepatitis
#17
REVIEW
Justin D Schumacher, Grace L Guo
Drug-induced steatohepatitis is a rare form of liver injury known to be caused by only a handful of compounds. These compounds stimulate the development of steatohepatitis through their toxicity to hepatocyte mitochondria; inhibition of beta-oxidation, mitochondrial respiration, and/or oxidative phosphorylation. Other mechanisms discussed include the disruption of phospholipid metabolism in lysosomes, prevention of lipid egress from hepatocytes, targeting mitochondrial DNA and topoisomerase, decreasing intestinal barrier function, activation of the adenosine pathway, increasing fatty acid synthesis, and sequestration of coenzyme A...
November 15, 2015: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/26336986/interferon-gamma-inducible-protein-10-ip10-induced-cisplatin-resistance-of-hcc-after-liver-transplantation-through-er-stress-signaling-pathway
#18
Wei Geng, Chung-Mau Lo, Kevin T P Ng, Chang-Chun Ling, Xiang Qi, Chang-Xian Li, Yuan Zhai, Xiao-Bing Liu, Yuen-Yuen Ma, Kwan Man
Tumor recurrence remains an obstacle after liver surgery, especially in living donor liver transplantation (LDLT) for patients with hepatocellular carcinoma (HCC). The acute-phase liver graft injury might potentially induce poor response to chemotherapy in recurrent HCC after liver transplantation. We here intended to explore the mechanism and to identify a therapeutic target to overcome such chemoresistance. The associations among graft injury, overexpression of IP10 and multidrug resistant genes were investigated in a rat liver transplantation model, and further validated in clinical cohort...
September 29, 2015: Oncotarget
https://www.readbyqxmd.com/read/26318299/synergistic-efficacy-of-%C3%AE-radiation-together-with-gallium-trichloride-and-or-doxorubicin-against-ehrlich-carcinoma-in-female-mice
#19
Eman Kandil, Nahed Abdel Aziz
Combining chemotherapy with radiotherapy represents a key oncology strategy for a more comprehensive attack toward cancers and improves treatment outcome for various solid tumor malignancies. The present study aims to evaluate the synergistic antitumor effect of γ-radiation together with gallium trichloride (GaCl3) and/or doxorubicin (DOX) against solid Ehrlich carcinoma (EC) in female mice. GaCl3 (300 mg/kg body weight (b.w.)) was administered by gavages daily on the seventh day after tumor inoculation, while the cytotoxic drug DOX (4 mg/kg b...
February 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26305238/interplay-of-inflammation-and-endothelial-dysfunction-in-bone-marrow-transplantation-focus-on-hepatic-veno-occlusive-disease
#20
REVIEW
Anne-Clémence Vion, Pierre-Emmanuel Rautou, François Durand, Chantal M Boulanger, Dominique C Valla
Endothelial cells are unique multifunctional cells with basal and inducible metabolic and synthetic functions. Various stimuli can induce physiological or pathological changes in endothelial cell biology. Hematopoietic stem cell transplantation (HSCT) requires high-dose irradiation and/or chemotherapy and is associated with increased risk of bacterial infections and immune reactions. These factors can affect endothelial cells. This review provides an overview of the effects of HSCT on endothelial cells, based on findings observed in cultured cells as well as in patients...
September 2015: Seminars in Thrombosis and Hemostasis
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