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https://www.readbyqxmd.com/read/29134411/distinct-roles-of-ecto-nucleoside-triphosphate-diphosphohydrolase-2-ntpdase2-in-liver-regeneration-and-fibrosis
#1
Linda Feldbrügge, Z Gordon Jiang, Eva Csizmadia, Shuji Mitsuhashi, Stephanie Tran, Eric U Yee, Sonja Rothweiler, Kahini A Vaid, Jean Sévigny, Moritz Schmelzle, Yury V Popov, Simon C Robson
Ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDases) are cell surface-located transmembrane ecto-enzymes of the CD39 superfamily which regulate inflammation and tissue repair by catalyzing the phosphohydrolysis of extracellular nucleotides and modulating purinergic signaling. In the liver, NTPDase2 is reportedly expressed on portal fibroblasts, but its functional role in regulating tissue regeneration and fibrosis is incompletely understood. Here, we studied the role of NTPDase2 in several models of liver injury using global knockout mice...
November 13, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/29131053/an-experimental-study-to-measure-the-mechanical-properties-of-the-human-liver
#2
Alireza Karimi, Ahmad Shojaei
BACKGROUND: Since the liver is one of the most important organs of the body that can be injured during trauma, that is, during accidents like car crashes, understanding its mechanical properties is of great interest. Experimental data is needed to address the mechanical properties of the liver to be used for a variety of applications, such as the numerical simulations for medical purposes, including the virtual reality simulators, trauma research, diagnosis objectives, as well as injury biomechanics...
October 31, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/29130552/resveratrol-pretreatment-enhanced-homing-of-sdf-1%C3%AE-preconditioned-bone-marrow-derived-mesenchymal-stem-cells-in-a-rat-model-of-liver-cirrhosis
#3
Mehrdad Hajinejad, Parichehr Pasbakhsh, Ameneh Omidi, Keywan Mortezaee, Saied Nekoonam, Reza Mamoudi, Iraj Ragerdi Kashani
Stromal cell-derived factor-1α (SDF-1α) has been known to implicate in homing of MSCs, and resveratrol has been reported to have a positive influence on SDF-1 level in the site of injury. In this study, a combined strategy was applied to evaluate bone marrow-derived MSCs (BMSCs) homing to the rat model of liver cirrhosis induced by common bile duct ligation (CBDL): (1) pretreatment delivery of resveratrol into the cirrhotic liver, and (2) transplantation of ex vivo BMSC preconditioning with SDF-1α. BMSCs were preconditioned with 10 ng/μl SDF-1α for 1h and then labelled with the CM-Dil...
November 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29127519/neutrophil-biology-within-hepatic-environment
#4
REVIEW
Débora Moreira Alvarenga, Matheus Silvério Mattos, Alan Moreira Araújo, Maísa Mota Antunes, Gustavo Batista Menezes
Neutrophils are the most abundant leukocyte in the human circulation. These short-lived cells are constantly produced from hematopoietic stem cells (HSC) within the bone marrow from which they daily reach the blood and perform major roles in innate immunity. Neutrophils are the first cells to reach inflamed tissues and are armed with a plethora of enzymes that help both with their trafficking within tissues and the killing of pathogens. Damaged or infected organs are rapidly invaded by neutrophils. Their erroneous activation within parenchyma or the vasculature is involved in the pathogenesis of several inflammatory diseases including arthritis, colitis, sepsis, acute lung injury and liver failure...
November 10, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29107739/comparative-restoration-of-acute-liver-failure-by-menstrual-blood-stem-cells-compared-with-bone-marrow-stem-cells-in-mice-model
#5
Mina Fathi-Kazerooni, Gholamreza Tavoosidana, Masoud Taghizadeh-Jahed, Sayeh Khanjani, Hananeh Golshahi, Caroline E Gargett, Haleh Edalatkhah, Somaieh Kazemnejad
BACKGROUND AIMS: The application of menstrual blood stem cells (MenSCs) in regenerative medicine is gaining increasing attention. The aim of this study was to investigate the therapeutic potential of MenSCs compared with bone marrow-derived stem cells (BMSCs) in an animal model of CCl4-induced acute hepatic failure. METHODS: Injured Balb/C mice were divided into multiple groups and received MenSCs, BMSCs or hepatocyte progenitor-like (HPL) cells derived from these cells...
October 26, 2017: Cytotherapy
https://www.readbyqxmd.com/read/29105510/microrna-29a-mitigation-of-endoplasmic-reticulum-and-autophagy-aberrance-counteracts-in-obstructive-jaundice-induced-fibrosis-in-mice
#6
Ying-Hsien Huang, Ya-Ling Yang, Fu-Chen Huang, Mao-Meng Tiao, Yen-Cheng Lin, Ming-Horng Tsai, Feng-Sheng Wang
Hepatic fibrosis was caused by a number of signaling pathways that damage liver integrity. We have previously shown that microRNA-29a (miR-29a) protects against liver fibrosis. Aberrant endoplasmic reticulum (ER) and autophagy function reportedly exaggerate hepatic disorders. The aim of this study was to characterize the biological influence of miR-29a on ER function in injured livers with bile duct ligation (BDL). We performed BDL on miR-29a transgenic mice (miR-29aTg) and wild-type mice to induce cholestatic liver injury...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29103285/the-effect-of-dietary-asparagine-supplementation-on-energy-metabolism-in-liver-of-weaning-pigs-when-challenged-with-lipopolysaccharide
#7
Ping Kang, Yulan Liu, Huiling Zhu, Jing Zhang, Haifeng Shi, Shuang Li, Dingan Pi, Weibo Leng, Xiuying Wang, Huanting Wu, Yongqing Hou
Objective: This experiment was conducted to investigate whether asparagine (Asn) could improve liver energy status in the weaning pigs when challenged with lipopolysaccharide. Methods: Forty-eight weaned pigs (Duroc × Large White × Landrace, 8.12±0.56 kg) were assigned to four treatments: 1) CTRL, piglets received a control diet and injected with sterile 0.9% NaCl solution; 2) LPSCC, piglets received the same control diet and injected with Escherichia coli LPS; 3) LPS + 0...
November 3, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/29097870/adipose-derived-stromal-cells-resemble-bone-marrow-stromal-cells-in-hepatocyte-differentiation-potential-in-vitro-and-in-vivo
#8
Li-Juan Xu, Shu-Fang Wang, De-Qing Wang, Lian-Jun Ma, Zheng Chen, Qian-Qian Chen, Jun Wang, Li Yan
AIM: To investigate whether mesenchymal stem cells (MSCs) from adipose-derived stromal cells (ADSCs) and bone marrow stromal cells (BMSCs) have similar hepatic differentiation potential. METHODS: Mouse ADSCs and BMSCs were isolated and cultured. Their morphological and phenotypic characteristics, as well as their multiple differentiation capacity were compared. A new culture system was established to induce ADSCs and BMSCs into functional hepatocytes. Reverse transcription polymerase chain reaction, Western blot, and immunofluorescence analyses were performed to identify the induced hepatocyte-like cells...
October 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29080878/-possible-use-of-the-growing-liver-biological-set-for-hepatic-recovery-after-toxic-damage-an-experimental-study
#9
E I Gal Perin, R I Ataullakhanov, T G Dyuzheva, L V Platonova, T M Melnikova, M Yu Monakov, A M Dudchenko, A V Lyundup, I D Klabukov
The lack of acceptable pharmacological approaches for restoration of the injured liver is associated with complex of mechanisms involved in hepatic regeneration and with difficulty of the target selection. The aim of this research was to study the hepatoprotective function of the extract from both the growing and regenerating liver containing a natural set of factors crucial for the hepatic restoration. Extracts from both regenerating liver of rats after 70% hepatic resection and the growing liver of neonatal pigs were obtained using own original technique...
October 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29078082/evaluating-the-regenerative-potential-and-functionality-of-human-liver-cells-in-mice
#10
REVIEW
Antson Kiat Yee Tan, Kyle M Loh, Lay Teng Ang
Liver diseases afflict millions of patients worldwide. Currently, the only long-term treatment for liver failure is the transplantation of a new liver. However, intravenously transplanting a suspension of human hepatocytes might be a less-invasive approach to partially reconstitute lost liver functions in human patients as evinced by promising outcomes in clinical trials. The purpose of this essay is to emphasize outstanding questions that continue to surround hepatocyte transplantation. While adult primary human hepatocytes are the gold standard for transplantation, hepatocytes are heterogeneous...
September 18, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/29077159/inflammatory-factor-in-donor-liver-and-its-effect-on-recipient-myocardial-injury-after-liver-transplantation
#11
J-B Chen, G-Y Chen, S-D Wei, J-J Sun, G-B Liu, Z-T Xie, G-F Tang
OBJECTIVE: To study the inflammatory factors in donor livers and its effect on recipient myocardial injury after liver transplantation recipients. PATIENTS AND METHODS: Eighteen patients who underwent orthotopic liver transplantations between January 2014 and December 2015 in our hospital were selected. A portion of the hepatic venous blood of donor's livers was preserved in heparinized tubes after partial resection. The concentrations of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), cardiac troponin I (cTnI), creatine kinase isoenzyme (CK-MB), and the activity of lactate dehydrogenase (LDH) in serum were measured...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29072685/sirt3-protects-hepatocytes-from-oxidative-injury-by-enhancing-ros-scavenging-and-mitochondrial-integrity
#12
Jingxin Liu, Dan Li, Tian Zhang, Qiang Tong, Richard Dequan Ye, Ligen Lin
Evidences of oxidative stress and mitochondrial dysfunction have been recognized in most of clinical and experimental liver diseases. SIRT3, a member of NAD(+)-dependent deacetylases, is mainly localized in mitochondria. So far, the role of SIRT3 in protecting hepatocytes against oxidative stress remains elusive. Herein, we found SIRT3 protein expression is decreased in tert-butyl hydroperoxide (t-BHP)-treated AML12 cells in vitro and primary hepatocytes from CCl4-injured mice in vivo. To further verify the role of SIRT3 in protecting hepatocytes from t-BHP-induced injury, SIRT3 overexpressed AML12 cell line and primary hepatocytes were generated...
October 26, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29072497/efficacy-and-safety-of-ultrasound-guided-percutaneous-glue-embolization-in-iatrogenic-haemorrhagic-complications-of-paracentesis-and-thoracocentesis-in-cirrhotic-patients
#13
Amar Mukund, Vinay Kumar Dp, Naveen Kumar Condati, Ajeet Singh Bhadoria, Shiv Kumar Sarin
OBJECTIVE: To compare the safety and efficacy of ultrasound guided percutaneous glue (N-butyl-2-cyanoacrylate) embolization with transarterial embolization in the management of iatrogenically injured arteries while performing paracentesis or thoracocentesis in patients with chronic liver disease. METHODS: Hospital database was searched for cirrhotic patients having abdominal/thoracic wall haemorrhage following paracentesis/thoracocentesis procedure from January 2011 to June 2016...
November 8, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29069643/-repair-treg-cells-in-tissue-injury
#14
Chaoqi Zhang, Lifeng Li, Kexin Feng, Daoyang Fan, Wenhua Xue, Jingli Lu
Studies in mice and humans have elucidated an important role for Tregs in promoting tissue repair and restoring tissue integrity. Emerging evidence has revealed that Tregs promoted wound healing and repair processes at multiple tissue sites, such as the heart, liver, kidney, muscle, lung, bone and central nervous system. The localization of repair Tregs in the lung, muscle and liver exhibited unique phenotypes and functions. Epidermal growth factor receptor, amphiregulin, CD73/CD39 and keratinocyte growth factor are important repair factors that are produced or expressed by repair Tregs; these factors coordinate with parenchymal cells to limit injury and promote repair...
October 25, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29066412/schisandrol-b-promotes-liver-regeneration-after-partial-hepatectomy-in-mice
#15
Xi Li, Jiahong Sun, Xiaomei Fan, Lihuan Guan, Dongshun Li, Yawen Zhou, Xuezhen Zeng, Yixin Chen, Huizhen Zhang, Leqian Xu, Fulin Jiang, Min Huang, Huichang Bi
Liver regeneration is a vital process of recovery after liver damage, which is a promising clinical strategy after partial hepatectomy (PHx). Schisandrol B (SolB), one of the bioactive ingredients from Schisandra sphenanthera, displays significant hepato-protection effects against drug-induced liver injure in mice. However, the effect of SolB on liver regeneration after PHx remains unclear. Here, we showed that SolB treatment promoted liver mass restoration and increased the number of proliferative hepatocytes following PHx...
October 21, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29063370/pathways-of-production-and-delivery-of-hepatocyte-exosomes
#16
Li Chen, Ruju Chen, Sherri Kemper, David R Brigstock
Hepatocyte exosomes (Exo(Hep)) are proposed to mediate physiological or pathophysiological signaling in a variety of hepatic target cells. Exo(Hep) were purified from the medium of primary mouse hepatocytes or AML12 cells and characterized as ~100 nm nanovesicles that were positive for proteins commonly found in exosomes (CD9, CD81, flotillin) or hepatocytes (asialoglycoprotein receptor). Ethanol treatment of hepatocytes caused increased Exo(Hep) release and increased cellular mRNA expression of components involved in intracellular vesicle trafficking (Rab 5a,b,c, Rab 7a, Rab 27a,b) or exosome biogenesis via the ESCRT (HGS, Alix, STAM1, TSG101, VTA1, YKT6) or ceramide (nSmase2) pathways...
October 23, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29061710/heparinase-is-essential-for-pseudomonas-aeruginosa-virulence-during-thermal-injury-and-infection
#17
Nyaradzo Dzvova, Jane A Colmer-Hamood, John A Griswold, Abdul N Hamood
The opportunistic pathogen Pseudomonas aeruginosa is a major cause of sepsis in severely burned patients. If not eradicated from the wound, it translocates to the bloodstream causing sepsis, multiorgan failure, and death. We recently described the P. aeruginosa heparinase-encoding gene, hepP, whose expression was significantly enhanced when P. aeruginosa strain PA14 was grown in whole blood from severely burned patients. Further analysis demonstrated that hepP contributed to in vivo virulence of PA14 in the C...
October 23, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29054137/il-35-gene-modified-mesenchymal-stem-cells-protect-the-con-a-induced-fulminant-hepatitis-through-decreasing-the-ifn-g-level
#18
Wei Wang, Hao Guo, Hongyue Li, Yongjia Yan, Chao Wu, Xiaodong Wang, Xianghui He, Na Zhao
Interleukin 35 (IL-35) is a relatively newly identified cytokine required for the regulatory and suppressive functions of regulatory T cells(Treg), playing an important role in the prevention of autoimmune diseases. In this study, we used the MSCs as the gene-delivery vehicles for IL-35 gene therapy and investigated their protective effects in Con A-induced autoimmune hepatitis. Results showed that IL-35 gene modified MSCs(IL-35-MSCs) can specifically migrate to the injured liver tissues and significantly narrow the necrosis areas and reduce the hepatocytes apoptosis...
October 20, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/29052835/role-of-percutaneous-transhepatic-biliary-drainage-in-the-management-of-blunt-liver-trauma-a-case-report
#19
Şükrü Oğuz, Reyyan Yıldırım, Serdar Topaloğlu
The liver is the most commonly injured intra-abdominal organ after blunt trauma. The management of massive liver injury is complex. Percutaneous transhepatic biliary drainage is the first approach considered, particularly for proximal bile duct strictures after liver surgery. A 27-year-old female patient was transferred to our emergency department with grade V blunt injury. Regarding the patient's unresponsive hemodynamic instability, right hepatectomy was performed. The patient presented with benign biliary duct stricture after surgery that were treated via the percutaneous approach...
September 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29045904/inkt-cells-orchestrate-a-switch-from-inflammation-to-resolution-of-sterile-liver-injury
#20
Pei Xiong Liew, Woo-Yong Lee, Paul Kubes
After traumatic injury, some cells function as detectors to sense injury and to modulate the local immune response toward a restitution phase by affecting the local cytokine milieu. Using intravital microscopy, we observed that patrolling invariant natural killer T (iNKT) cells were initially excluded from a site of hepatic injury but subsequently were strategically arrested first via self-antigens and then by cytokines, circumscribing the injured site at exactly the location where monocytes co-localized and hepatocytes proliferated...
October 17, 2017: Immunity
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